BIO-electronic device to modulate nerve, tumor or organ tissue in cancer pathology and compliment chemotherapy or immunotherapy drugs to targeted cancer pathology

A bio-electronic device modulates nerve activity using high impedance electrodes to complement chemotherapy or immunotherapy, addressing cancer progression by reducing tumor proliferation and angiogenesis, thus improving treatment efficacy.

WO2026112467A1PCT designated stage Publication Date: 2026-05-28MEDTIMO
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
MEDTIMO
Filing Date
2025-11-21
Publication Date
2026-05-28

AI Technical Summary

Technical Problem

Despite advancements in cancer treatments like chemotherapy and immunotherapy, cancer remains a significant health issue with high mortality rates due to the activation of autonomic nervous system receptors promoting tumor proliferation, migration, and angiogenesis.

Method used

A bio-electronic device with high impedance electrodes is implanted to modulate nerve activity by applying electrical signals, combined with pharmaceutical agents, to downregulate or upregulate activity on target nerves, organs, or tumors, thereby complementing chemotherapy or immunotherapy.

Benefits of technology

The device effectively reduces cancer progression by minimizing power consumption, ensuring safety, and enhancing compatibility with magnetic resonance imaging, while providing therapeutic benefits comparable to or better than pharmaceutical agents alone.

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Abstract

A system and methods for treating gastrointestinal, lung, breast, stomach, liver, pancreas, ovary, prostate, small bowel, bladder, kidney, uterine cervix, thyroid and bone marrow cancers are performed where the nerve is selected from the vagus nerve and its individual branches and / or splanchnic nerve, and / or celiac complex. In embodiments, at least one electrode is placed on or near the vagus nerve. In each of the aforementioned embodiments, the electrical signal therapy can be combined with administration of therapeutic agents that affects the growth or proliferation cancerous cells.
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