Heterocyclic compounds and methods for treating cancers expressing sulfotransferase (SULT) enzymes

Heterocyclic compounds selectively activated by SULT1 enzymes provide targeted antitumor activity in SULT1-positive cancers, addressing the need for precision oncology treatments with high efficacy and reduced toxicity.

WO2026142867A1PCT designated stage Publication Date: 2026-07-02UP THERAPEUTICS LLC
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
UP THERAPEUTICS LLC
Filing Date
2025-12-12
Publication Date
2026-07-02

AI Technical Summary

Technical Problem

There is an urgent need for precision oncology treatments that selectively target SULT1-positive cancers with high efficacy and minimal toxicity, as existing therapies often cause off-target toxicity due to non-specific activation in normal tissues.

Method used

Development of heterocyclic compounds that are selectively activated by SULT1 enzymes, forming cytotoxic metabolites in SULT1-high cancer cells while remaining inactive in SULT1-negative tumors, thereby minimizing off-target effects.

Benefits of technology

The compounds demonstrate potent antitumor activity in SULT1-expressing cancers with minimal toxicity to normal tissues, providing a targeted therapeutic approach.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure IMGF000003_0001
    Figure IMGF000003_0001
  • Figure IMGF000003_0002
    Figure IMGF000003_0002
  • Figure IMGF000004_0001
    Figure IMGF000004_0001
Patent Text Reader

Abstract

The present disclosure relates to heterocyclic compounds, pharmaceutical compositions comprising said compounds and a method of treating cancer comprising administering the compounds, or compositions thereof to a subject in need thereof. Specifically, the present disclosure provides heterocyclic compounds useful as anti-cancer agents, pharmaceutical compositions comprising said compounds and a method of treating SULT1 positive cancer comprising administering the compounds, or compositions thereof to a subject in need thereof.
Need to check novelty before this filing date? Find Prior Art