Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof

Abstract

Provided herein are compounds of formula (I') or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Y2, Y3, L1, L2, X1, X2, X3, X4, X5, Q1, R1, R2, Rk, Rm, and Rn are as defined elsewhere herein. Also provided herein are methods of preparing compounds of formula (F). Also provided herein are methods of inhibiting GYS1 and methods of treating a GYS1 -mediated disease, disorder, or condition in an individual in need thereof.

Description

[0161] In some embodiments of a compound of formula (I’), (I-A2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more Rc, wherein Rcis oxo, Ci-6alkyl, or -C(O)-Ci-6alkoxy, wherein the Ci-6alkyl of Rc is optionally substituted with one or more halo , and the -C(O)-Ci-6alkoxy of Rc is optionally substituted with one or more halo. In some embodiments, R2 is selected from the group .In some embodiments of a compound of formula (I-A2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-6alkyl, wherein the Ci-6alkyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re, wherein Re is - C(O)-(3-15 membered heterocyclyl). In some embodiments, R2 is embodiments of a compound of formula (I’), (I-A2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re, wherein Re is -C(O)-(3-15 membered heterocyclyl)wherein the -C(O)-(3-15 membered heterocyclyl) of Re is optionally substituted with one or more Ci-6alkyl, wherein the Ci-ealky 1 is optionally substituted with one or more halo, Ci-ealkoxy, or Cs-iocycloalkyl. In some embodiments, R2 is selected from the group consisting of

[0162] In some embodiments of a compound of formula (I-A2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealkyl, wherein the Ci-6alkyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of Rc and Rd is -C(O)-N(Ci-6alkyl)2. In some embodiments, R2 is 0 . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.In some embodiments of a compound of formula (I’), (I- A2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of Rc and Rd, -C(O)-Ci-6alkyl, -C(O)-N(Ci-6alkyl)2, or -C(O)-(3-15 membered heterocyclyl). In some embodiments, R2 is selected from the group consisting of O ,        0

[0163] In some embodiments of a compound of formula (I’) (I-A2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is ethyl, wherein the ethyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of Rc and Rd , is -C(O)-Ci-6alkyl. In some embodiments, R2 is

[0164] In some embodiments, provided herein is a compound of formula (I) or formula (I-A), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein the compound is a compound of formula (I-A3): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Rx is H, halo, Ci-ealky 1, or -NH2, wherein the Ci-ealkyl is optionally substituted with one or more halo; and Ry is (i) Ci-ealkyl, (ii), C2-ealkenyl, or (iii) Cs-iocycloalkyl, wherein the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl. In some embodiments, Rx is H, halo, Ci-ealkyl, or -NH2; and Ry is (i) Ci-ealkyl or (ii) Cs-iocycloalkyl, wherein the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl. In some variations, R2, Rk, Rx, and Ry of formula (I-A3) are as defined for a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof, wherein Rx and Ry are each independently H, halo, Ci-ealkyl, C2-6alkenyl, Ci-ealkoxy, -NH2, or Cs-iocycloalkyl, wherein, the Ci-ealkyl is optionally substituted with one or more halo, and the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl,. In some embodiments, Rx is H, halo, Ci-ealkyl, or -NH2; and Ry is (i) Ci-ealkyl or (ii) Cs-iocycloalkyl, wherein the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl.

[0165] In some embodiments of a compound of formula (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rx is H, fluoro, or methyl; and Ry is (i) H, (ii) isopropyl, (iii) tert-butyl, or (iv) C3-4cycloalkyl, wherein the C3-4cycloalkyl is optionally substituted with one or more fluoro or methyl. In some embodiments, Rx is H, fluoro, or methyl; and Ry is (i) isopropyl or (ii) C3-4cycloalkyl, wherein the C3-4cycloalkyl is optionally substituted with one or more fluoro or methyl. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0166] In some embodiments of a compound of formula (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rk is H or halo. In some embodiments of a compound of formula (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rk is H or fluoro. In some embodiments of a compound of formula (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rk is fluoro. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0167] In some embodiments of a compound of formula (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is optionally substituted with one or more Ra. In some embodiments, R2 is Ci-ealkyl, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of Ra is optionally substituted with one or more Rb. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 510 membered heteroaryl of Ra is optionally substituted with one or more Rb. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl of Ra is optionally substituted with one or more Ci-6alkyl, wherein the Ci-6alkyl is optionally substituted with one or more halo, -NH2, -NH(Ci-6alkyl), -N(Ci-6alkyl)2, -NH-C(O)Ci-6alkyl, or -NH-C(O)-Ci-6alkoxy. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl of Ra is optionally substituted with one or more methyl, wherein the methyl is optionally substituted with one or more fluoro. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0168] In some embodiments of a compound of formula (I’), (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is -(Ci-4alkyl)(5-20 membered heteroaryl), wherein the 5-20 membered heteroaryl is optionally substituted with one or more Rs. In some embodiments, Rs is halo, Ci-6alkyl, Ci-6alkoxy, -NH2, -NH(Ci-6alkyl), -N(Ci-6alkyl)2, -NH-C(O)-Ci-6alkyl, C6-2oaryl, C3-iocycloalkyl, 315 membered heterocyclyl, 5-20 membered heteroaryl, or -C(O)-Ci-6alkoxy. In some embodiments, the Ci-6alkyl of Rs is optionally substituted with one or more halo, Ci-6alkoxy, -NH2,-NH(Ci-6alkyl), -N(Ci-6alkyl)2, -NH-C(O)Ci-6alkyl, or -NH-C(O)-Ci-6alkoxy, and the 3-15membered heterocyclyl of Rs is optionally substituted with one or more halo or -C(O)-Ci-ealkoxy.

[0169] In some embodiments of a compound of formula (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is selected HN'N embodiments, R2 is             . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0170] In some embodiments of a compound of formula (I’), (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, some embodiments, R2 is In some embodiments, R2 is

[0171] In some embodiments of a compound of formula (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more oxo or Ci-6alkyl. In some embodiments, R2 is 0     . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0172] In some embodiments of a compound of formula (I’), (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more Rc, wherein Rcis oxo, Ci-6alkyl, or -C(O)-Ci-6alkoxy, wherein the Ci-6alkyl of Rc is optionally substituted with one or more halo , and the -C(O)-Ci-ealkoxy of Rc is optionally substituted with one or more halo. In some embodiments, R2 is

[0173] In some embodiments of a compound of formula (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re, wherein Re is -C(O)-(3-15 membered heterocyclyl). In some embodiments, R2 is In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof. In some embodiments of a compound of formula (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-6alkyl, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of Rc and Rd 97 is -C(O)-N(Ci-6alkyl)2. In some embodiments, R2 is 0    . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0174] In some embodiments of a compound of formula (I’), (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of Rc and Rd, -C(O)-Ci-6alkyl, -C(O)- N(Ci-6alkyl)2, or -C(O)-(3-15 membered heterocyclyl), wherein the -C(O)-(3-15 membered heterocyclyl) of Rc or Rd is optionally substituted with one or more halo, -C(O)-Ci-6alkoxy, or Ci-6alkyl, and the Ci-6alkyl of the -C(O)-N(Ci-6alkyl)2 of Rc or Rd are, independently of each other, optionally substituted with one or more halo or C6-2oaryl. In some embodiments, R2 is

[0175] In some embodiments of a compound of formula (I’), (I-A3), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of Rc and Rd is 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of Rc or Rd are independently optionally substituted with one or more Ci-6alkyl. In some embodiments, R2 is

[0176] In some embodiments, provided herein is a compound of formula (I) or formula (I-A), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein the compound is a compound of formula (I-A4): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Rz is H, halo, Ci-ealky 1, or -NH2 and Ry is (i) Ci-ealkyl, (ii), C2-ealkenyl, or (iii) Cs-iocycloalkyl, wherein the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl. In some embodiments, Rz is H, halo, or Ci-ealkyl; and Ry is (i) Ci-ealkyl, (ii), C2-ealkenyl, or (iii) Cs-iocycloalkyl, wherein the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl. In some embodiments, Rz is H or Ci-ealkyl; and Ry is (i) Ci-ealkyl or (ii) Cs-iocycloalkyl, wherein the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl. In some embodiments of a compound of formula (I-A4), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rz is H or methyl; and Ry is (i) isopropyl, or (ii) C3-4cycloalkyl. In some variations, R2, Rk, Ry, and Rz of formula (I-A4) are as defined for a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof, wherein Ry and Rz are each independently H, halo, Ci-6alkyl, C2-6alkenyl, Ci-ealkoxy, -NH2, or Cs-iocycloalkyl, wherein, the Ci-ealkyl is optionally substituted with one or more halo, and the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl. In some embodiments, Rz is H, halo, or Ci-ealkyl, wherein the Ci-ealkyl of Rz is optionally substituted with one or more halo; and Ry is (i) Ci-ealkyl, (ii), or (ii) Cs-iocycloalkyl, wherein the C3- locycloalkyl is optionally substituted with one or more halo or Ci-ealkyl. In some embodiments of a compound of formula (I-A4), or a stereoisomer or tautomer thereof, or a pharmaceutically 99 acceptable salt of any of the foregoing, Rz is H or methyl, wherein the methyl of Rz is optionally substituted with one or more halo; and Ry is (i) isopropyl, or (ii) C3-4cycloalkyl.

[0177] In some embodiments of a compound of formula (I-A4), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rk is H or halo. In some embodiments of a compound of formula (I-A4), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rk is H or fluoro. In some embodiments of a compound of formula (I-A4), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rk is fluoro. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0178] In some embodiments of a compound of formula (I-A4), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is optionally substituted with one or more Ra. In some embodiments, R2 is Ci-ealkyl, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of Ra is optionally substituted with one or more Rb. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 510 membered heteroaryl of Ra is optionally substituted with one or more Rb. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl of Ra is optionally substituted with one or more Ci-6alkyl, wherein the Ci-6alkyl is optionally substituted with one or more halo, -NH2, -NH(Ci-6alkyl), -N(Ci-6alkyl)2, -NH-C(O)Ci-6alkyl, or -NH-C(O)-Ci-6alkoxy. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl of Ra is optionally substituted with one or more methyl, wherein the methyl is optionally substituted with one or more fluoro.

[0179] In some embodiments of a compound of formula (I-A4), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is selected HN'N /       N embodiments, R2 is             . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0180] In some embodiments of a compound of formula (I-A4), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more oxo or Ci-6alkyl. In some embodiments, R2 is 0     . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0181] In some embodiments of a compound of formula (I-A4), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-6alkyl, wherein the C ।-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re, wherein Re is -C(O)-(3-15 membered heterocyclyl). In [^NH some embodiments, R2 is O         . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0182] In some embodiments of a compound of formula (I-A4), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of Rc and Rd is -C(O)-N(Ci-6alkyl)2. In some embodiments, R2 is 0    . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0183] In some embodiments, provided herein is a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein the compound is a compound of formula (I-B):

[0184] or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Y1 is CH or N; Rx is H, halo, Ci-6alkyl, or -NH2, wherein, when Y1 is CH, the Ci-6alkyl of Rx may be optionally substituted with one or more halo; Ry is (i) Ci-ealkyl, (ii), C2-6alkenyl, or (iii) Cs-iocycloalkyl, wherein the Cs-iocycloalkyl is optionally substituted with one or more halo or Cl-6alkyl; and Rk is taken together with either Rm or Rn, and the atoms to which they are attached, to form cyclopropyl. In some variations, Y1, R2, Rk, Rm, R“, Rx, Ry, and Rzof formula (I-B) are as defined for a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof, wherein Y1 is CRX or N; wherein, when the ring bearing Rx, and Ry is phenyl, Rx, and Ry are each independently H, halo, Ci-ealky 1, C2-ealkenyl, -NH2, -NH-C(O)-(Ci-ealkyl), -NH-C(O)-(3-15 membered heterocyclyl), Cs-iocycloalkyl, or 5-20 membered heteroaryl, wherein the Ci-ealkyl is optionally substituted with one or more halo, -NH-C(O)-NH(Ci-6alkyl), -NH-C(O)-Ci-6alkyl, or -NH-C(O)-Ci-6alkoxy, and the C3-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl, and the 5-20 membered heteroaryl is optionally substituted with one or more Ci-6alkyl; and wherein when the ring bearing Rx, and Ry is pyridyl, Rx, and Ry are each independently H, halo, Ci-6alkyl, C2-6alkenyl, Ci-ealkoxy, -NH2, or Cs-iocycloalkyl, wherein, the Ci-ealkyl is optionally substituted with one or more halo, and the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl.

[0185] In some embodiments of a compound of formula (I-B), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Y1 is CH or N; Rx is H, halo, Ci-ealkyl, or NH2, wherein, when Y1 is CH, the Ci-6alkyl of Rx may be optionally 103 substituted with one or more halo; and Ry is (i) Ci-6alkyl, (ii), C2-6alkenyl, or (iii) Cs-iocycloalkyl, wherein the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-6alkyl. In some embodiments, Y1 is CH or N; Rx is H or halo; Ry is Ci-6alkyl or Cs-iocycloalkyl; and Rk is taken together with either Rm or R“, and the atoms to which they are attached, to form cyclopropyl. In some embodiments, Y1 is CH or N; Rx is H or fluoro; Ry is (i) isopropyl or (ii) Cs^cycloalkyl; and Rk is taken together with either Rm or R“, and the atoms to which they are attached, to form cyclopropyl. In some embodiments, Y1 is CH or N; Rx is H or fluoro; Ry is (i) isopropyl or (ii) C3-4cycloalkyl; and Rk is taken together with Rm and the atoms to which they are attached to form cyclopropyl. In some embodiments, Y1 is CH or N; Rx is H or fluoro; Ry is (i) isopropyl or (ii) C3-4cycloalkyl; and Rk is taken together with R11 and the atoms to which they are attached to form cyclopropyl. In some embodiments, Y1 is CH; Rx is H or fluoro; Ry is (i) isopropyl or (ii) C3-4cycloalkyl; and Rk is taken together with Rn or R11 and the atoms to which they are attached to form cyclopropyl. In some embodiments, Y1 is N; Rx is H or fluoro; Ry is (i) isopropyl or (ii) C3-4cycloalkyl; and Rk is taken together with Rn or R11 and the atoms to which they are attached to form cyclopropyl. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0186] In some embodiments of a compound of formula (I-B), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is optionally substituted with one or more Ra. In some embodiments, R2 is Ci-ealkyl, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of Ra is optionally substituted with one or more Rb. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 510 membered heteroaryl of Ra is optionally substituted with one or more Rb. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl of Ra is optionally substituted with one or more Ci-6alkyl, wherein the Ci-6alkyl is optionally substituted with one or more halo, -NH2, -NH(Ci-6alkyl), -N(Ci-6alkyl)2, -NH-C(O)Ci-6alkyl, or -NH-C(O)-Ci-6alkoxy. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl of Ra is optionally substituted with one or more methyl, wherein the methyl is optionally substituted with one or more fluoro. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0187] In some embodiments of a compound of formula (I-B), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is selected HN'N embodiments, R is             . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0188] In some embodiments of a compound of formula (I-B), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more oxo or Ci-6alkyl. In some embodiments, R2 is 0     . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0189] In some embodiments of a compound of formula (I-B), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re, wherein Re is -C(O)-(3-15 membered heterocyclyl). In some embodiments, R2 is In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0190] In some embodiments of a compound of formula (I-B), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-6alkyl, wherein the Ci-6alkyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of Rc and Rd is -C(O)-N(Ci-6alkyl)2. In some embodiments, R2 is 0    . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0191] In some embodiments, provided here is a compound of formula (I) or formula (I-B), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein the compound is a compound of formula (I-B 1): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Y1 is CH or N; Rx is H or halo; and Ry is Ci-ealkyl or Cs-iocycloalkyl. In some embodiments, Y1 is CH or N; Rx is H or fluoro; and Ry is (i) isopropyl or (ii) C3- 4cycloalkyl. In some embodiments, Y1 is CH; Rx is H or fluoro; and Ry is (i) isopropyl or (ii) C3- 4cycloalkyl. In some embodiments, Y1 is N; Rx is H or fluoro; and Ry is (i) isopropyl or (ii) C3- 4cycloalkyl. In some variations, Y1, R2, Rx, and Ry of formula (I-Bl) are as defined for a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof, wherein Y1 is CRX or N; wherein, when the ring bearing Rx, and Ry is phenyl, Rx, and Ry are each independently H, halo, Ci-6alkyl, C2-6alkenyl, -NH2, -NH-C(O)-(Ci-6alkyl), -NH-C(O)-(3-15 membered heterocyclyl), Cs-iocycloalkyl, or 5-20 membered heteroaryl, wherein the Ci-ealkyl is optionally substituted with one or more halo, -NH-C(O)-NH(Ci-6alkyl), -NH-C(O)-Ci-6alkyl, or -NH-C(O)-Ci-6alkoxy, the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl, and the 5-20 membered heteroaryl is optionally substituted with one or more Ci-ealkyl; and wherein when the ring bearing Rx, and Ry is pyridyl, Rx, and Ry are each independently H, halo, Ci-6alkyl, C2-6alkenyl, Ci-ealkoxy, -NH2, or Cs-iocycloalkyl, wherein, the Ci-ealkyl is optionally substituted with one or more halo, and the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl.. In some embodiments, Y1 is CH or N; Rx is H or fluoro; and 107 Ry is (i) isopropyl or (ii) C3-4cycloalkyl. In some embodiments, Y1 is CH; Rx is H or fluoro; and Ry is (i) isopropyl or (ii) C3-4cycloalkyl. In some embodiments, Y1 is N; Rx is H or fluoro; and Ry is (i) isopropyl or (ii) C3-4cycloalkyl.

[0192] In some embodiments of a compound of formula (I-Bl), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Chalky I, wherein the Ci-6alkyl of R2 is optionally substituted with one or more Ra. In some embodiments, R2 is Ci-6alkyl, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of Ra is optionally substituted with one or more Rb. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 510 membered heteroaryl of Ra is optionally substituted with one or more Rb. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl of Ra is optionally substituted with one or more Ci-6alkyl, wherein the Chalky I is optionally substituted with one or more halo, -NH2, -NH(Ci-6alkyl), -N(Ci-6alkyl)2, -NH-C(O)Ci-6alkyl, or -NH-C(O)-Ci-6alkoxy. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl of Ra is optionally substituted with one or more methyl, wherein the methyl is optionally substituted with one or more fluoro. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0193] In some embodiments of a compound of formula (I-Bl), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is selected HN'N embodiments, R is             . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0194] In some embodiments of a compound of formula (I-Bl), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more oxo or Ci-6alkyl. In some embodiments, R2 is 0     . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0195] In some embodiments of a compound of formula (I-Bl), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-6alkyl, wherein the Ci-6alkyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re, wherein Re is -C(O)-(3-15 membered heterocyclyl). In NH some embodiments, R2 is . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0196] In some embodiments of a compound of formula (I-Bl), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of 0    . In some Rc and Rd is -C(O)-N(Ci-6alkyl)2. In some embodiments, R2 is variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0197] In some embodiments, provided herein is a compound of formula (I) or formula (I-B), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein the compound is a compound of formula (I-B2): (I-B2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Y1 is CH or N; Rx is H or halo; and Ry is Ci-6alkyl or Cs-iocycloalkyl. In some embodiments, Y1 is CH or N; Rx is H or fluoro; and Ry is (i) isopropyl or (ii) C3-4cycloalkyl. In some embodiments, Y1 is CH; Rx is H or fluoro; and Ry is (i) isopropyl or (ii) C3-4cycloalkyl. In some embodiments, Y1 is N; Rx is H or fluoro; and Ry is (i) isopropyl or (ii) C3-4cycloalkyl. In some variations, Y1, R2, Rx, and Ry of formula (I-B2) are as defined for a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof, wherein Y1 is is CRX or N; wherein, when the ring bearing Rx, and Ry is phenyl, Rx, and Ry are each independently H, halo, Ci-6alkyl, C2-6alkenyl, -NH2, -NH-C(O)-(Ci-6alkyl), -NH-C(O)-(3-15 membered heterocyclyl), Cs-iocycloalkyl, or 5-20 membered heteroaryl, wherein the Ci-6alkyl is optionally substituted with one or more halo, -NH-C(O)-NH(Ci-6alkyl), -NH-C(O)-Ci-6alkyl, or -NH-C(O)-Ci-6alkoxy, the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl, and the 5-20 membered heteroaryl is optionally substituted with one or more Ci-6alkyl; and wherein when the ring bearing Rx, and Ry is pyridyl, Rx, and Ry are each independently H, halo, Ci-6alkyl, C2-6alkenyl, Ci-ealkoxy, -NH2, or Cs-iocycloalkyl, wherein, the Ci-ealkyl is optionally substituted with one or more halo, and the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl. In some embodiments, Y1 is CH or N; Rx is H or fluoro; and Ry is (i) isopropyl or (ii) C3-4cycloalkyl. In some embodiments, Y1 is CH; Rx is H or fluoro; and Ry is (i) isopropyl or (ii) C3-4cycloalkyl. In some embodiments, Y1 is N; Rx is H or fluoro; and Ry is (i) isopropyl or (ii) C3-4cycloalkyl.

[0198] In some embodiments of a compound of formula (I-B2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-6alkyl, wherein the Ci-6alkyl of R2 is optionally substituted with one or more Ra. In some embodiments, R2 is Ci-ealkyl, wherein the Ci-6alkyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of Ra is optionally substituted with one or more Rb. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 510 membered heteroaryl of Ra is optionally substituted with one or more Rb. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl of Ra is optionally substituted with one or more Ci-6alkyl, wherein the Ci-ealkyl is optionally substituted with one or more halo, -NH2, -NH(Ci-ealkyl), -N(Ci-ealkyl)2, -NH-C(O)Ci-ealkyl, or -NH-C(O)-Ci-ealkoxy. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl of Ra is optionally substituted with one or more methyl, wherein the methyl is optionally substituted with one or more fluoro. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0199] In some embodiments of a compound of formula (I-B2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is selected hn-n 9 X embodiments, R is            . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0200] In some embodiments of a compound of formula (I-B2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, 112 wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more oxo or Ci-6alkyl. In some embodiments, R2 is A / N^NH Y 0     . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0201] In some embodiments of a compound of formula (I-B2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re, wherein Re is -C(O)-(3-15 membered heterocyclyl). In ^'NH some embodiments, R2 is O         . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0202] In some embodiments of a compound of formula (I-B2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-6alkyl, wherein the Ci-6alkyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of Y Rc and Rd is -C(O)-N(Ci-6alkyl)2. In some embodiments, R2 is 0    . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0203] In some embodiments, provided herein is a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein the compound is a compound of formula (I-C): X5 wherein X5 is H, Ci-6alkyl, Ci-6alkoxy, or Cs-iocycloalkyl; X4 is H, halo, Ci-6alkyl, Ci-6alkoxy, or 5-20 membered heteroaryl; Rv is -NH2, -NH-C(O)-(Ci-6alkyl), or -NH-C(O)-(3-15 membered heterocyclyl); and Rw is H, -NH2, -NH-C(O)-(Ci-6alkyl), or -NH-C(O)-(3-15 membered heterocyclyl). In some embodiments, X5 is H or Ci-6alkyl; X4 is H; Rv is -NH2, -NH-C(O)-(Ci-ealkyl), or -NH-C(O)-(3-15 membered heterocyclyl); and Rw is H, -NH2, -NH-C(O)-(Ci-6alkyl), or -NH-C(O)-(3-15 membered heterocyclyl). In some embodiments, Rw is H and Rv is -NH-C(O)Ci-6alkyl. In some embodiments, Rw is H and Rv is -NH-C(O)CH3. In some variations, R2, Rk, Rw, Rv, X4 and X5 of formula (I-C) are as defined for a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof, wherein X5 is H, Ci -ealkyl, Ci-ealkoxy, or C3-locycloalkyl; X4 is H, halo, Ci-ealkyl, Ci-ealkoxy, or 5-20 membered heteroaryl; Rv is -NH2, -NH-C(O)-(Ci-ealkyl), or -NH-C(O)-(3-15 membered heterocyclyl); and Rw is H, -NH2, -NH-C(O)-(Ci-ealkyl), or -NH-C(O)-(3-15 membered heterocyclyl). In some embodiments, X5 is H or Ci-ealkyl; X4 is H; Rv is -NH2, -NH-C(O)-(Ci-ealkyl), or -NH-C(O)-(3-15 membered heterocyclyl); and Rw is H, -NH2, -NH-C(O)-(Ci-ealkyl), or -NH-C(O)-(3-15 membered heterocyclyl). In some embodiments, Rw is H and Rv is -NH-C(O)Ci-6alkyl. In some embodiments, Rw is H and Rv is -NH-C(O)CH3.

[0204] In some embodiments, provided is a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein the compound is a compound of formula (I-D): X5 wherein X5 is H, Ci-6alkyl, Ci-6alkoxy, or Cs-iocycloalkyl; X4 is H, halo, Ci-6alkyl, Ci-6alkoxy, or 5-20 membered heteroaryl; and Rl and Ru are independently H, Ci-6alkoxy, or -NH2. In some embodiments, X5 is Ci-6alkyl; X4 is H, halo, or Ci-6alkyl; and Rl and Ru are independently H or -NH2. In some embodiments, at least one of Rl and Ru is -NH2. In some embodiments, Rl is H and Ru is -NH2. In some embodiments, Rl is -NH2 and Ru is H. In some variations, R2, Rk, R‘, Ru, X4 and X5 of formula (I-D) are as defined for a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof, wherein X5 is H, Ci-ealkyl, Ci-ealkoxy, or Cs-iocycloalkyl, ; X4 is H, halo, Ci-ealkyl, Ci-ealkoxy, or 5-20 membered heteroaryl; and Rl and Ru are independently H, Ci-ealkoxy, or -NH2. In some embodiments, X5 is Ci-ealkyl; X4 is H, halo, or Ci-ealkyl; and Rl and Ru are independently H or -NH2. In some embodiments, at least one of Rl and Ru is -NH2. In some embodiments, Rl is H and Ru is -NH2. In some embodiments, Rl is -NH2 and Ru is H.

[0205] In some embodiments of a compound of formula (I-C) or (I-D), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rkis H or halo. In some embodiments of a compound of formula (I-C) or (I-D), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rkis H or fluoro. In some embodiments of a compound of formula (I-C) or (I-D), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rk is fluoro. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0206] In some embodiments, provided is a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein the compound is a compound of formula (I-D 1): X5 wherein X5 is H, Ci-6alkyl, Ci-ealkoxy, or Cs-iocycloalkyl; X4 is H, halo, Ci-6alkyl, Ci-6alkoxy, or 5-20 membered heteroaryl; and Rl and Ru are independently H, Ci-6alkoxy, or -NH2. In some embodiments, X5 is Ci-6alkyl; X4 is H, halo, or Ci-6alkyl; and Ru and Rz are independently H, halo or -NH2. In some embodiments, at least one of Ru and Rz is -NH2. In some embodiments, Ru is H and Rz is -NH2. In some embodiments, Ru is -NH2 and Rz is H. In some embodiments, at least one of Ru and Rz is halo. In some embodiments, Ru is H and Rz is fluoro. In some embodiments, Ru is fluoro and Rz is H.

[0207] In some embodiments, provided is a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein the compound is a compound of formula (I-D2): X5 wherein X5 is H, Ci-6alkyl, Ci-ealkoxy, or Cs-iocycloalkyl; X4 is H, halo, Ci-6alkyl, Ci-ealkoxy, or 5-20 membered heteroaryl, wherein the Ci-6alkyl of X4 is optionally substituted with one of more halo; and Rl and Ru are independently H, Ci-ealkoxy, or -NH2. In some embodiments, X5 is Ci-ealkyl; X4 is H, halo, or Ci-ealkyl; and Ru and Rz are independently H, halo or -NH2. In some embodiments, at least one of Ru and Rz is -NH2. In some embodiments, Ru is H and Rz is -NH2. In some embodiments, Ru is -NH2 and Rz is H. In some embodiments, at least one of Ru and Rz is halo. In some embodiments, Ru is H and Rz is fluoro. In some embodiments, Ru is fluoro and Rz is H.

[0208] In some embodiments, provided is a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein the compound is a compound of formula (I-E): wherein Rk and Rm are independently H, OH, -NH2, or -NH-C(O)Ci-6alkyl. In some embodiments, Rk is H and Rm is H, OH, -NH2, or -NH-C(O)Ci-6alkyl. In some embodiments, Rk is H and Rm is OH. In some embodiments, Rk is H, OH, -NH2, or -NH-C(O)Ci-6alkyl, and Rm is H. In some embodiments, Rk is OH, -NH2, or -NH-C(O)Ci-6alkyl, and Rm is H. In some embodiments, Rk is OH, -NH2, or -NH-C(O)CH3, and Rm is H. In some variations, R2, Rk, and Rm of formula (I-E) are as defined for a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof, wherein Rk and Rm are independently H, OH, -NH2, or -NH-C(O)Ci-6alkyl. In some embodiments, Rk is H and Rm is H, OH, -NH2, or -NH-C(O)Ci-6alkyl. In some embodiments, Rk is H and Rm is OH. In some embodiments, Rk is H, OH, -NH2, or -NH-C(O)Ci-ealkyl, and Rm is H. In some embodiments, Rk is OH, -NH2, or -NH-C(O)Ci-6alkyl, and Rm is H. In some embodiments, Rk is OH, -NH2, or -NH-C(O)CH3, and Rm is H.

[0209] In some embodiments, provided is a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein the compound is a compound of formula (I-F): wherein Y1 is CH or N; Rx is H, halo, Ci-6alkyl, or -NH2, wherein, when Y1 is CH, the Ci-6alkyl of Rx may be optionally substituted with one or more halo; Ry is (i) Ci-6alkyl, (ii), C2-6alkenyl, or (iii) Cs-iocycloalkyl, wherein the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-6alkyl; Rk is H, halo, -OH, -NH2, or -NH-C(O)Ci-6alkyl; and R11 is H, Ci-6alkyl, or C3-locycloalkyl. In some embodiments, Y1 is CH or N; Rx is H, halo, or Ci-6alkyl; Ry is (i) Ci-6alkyl, (ii), C2-6alkenyl, or (iii) Cs-iocycloalkyl, wherein the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-6alkyl; Rk is H, halo, -OH, -NH2, or -NH-C(O)Ci-6alkyl; and R11 is H, Ci-ealkyl, or Cs-iocycloalkyl. In some variations, R2, Rk, Rx, Ry, and Rz of formula (I-F) are as defined for a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof, wherein Y1 is CH or N; Rx is H, halo, Ci-6alkyl, or -NH2, wherein, when Y1 is CH, the Ci-6alkyl of Rx may be optionally substituted with one or more halo; Ry is (i) Ci-6alkyl, (ii), C2-6alkcnyl or (iii) Cs-iocycloalkyl, wherein the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-6alkyl; Rk is H, halo, -OH, -NH2, or -NH-C(O)Ci-6alkyl; and R11 is H, Ci-6alkyl, or C3-locycloalkyl. In some embodiments, Y1 is CH or N; Rx is H, halo, or Ci-6alkyl; Ry is (i) Ci-6alkyl, or (ii) Cs-iocycloalkyl, wherein the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-6alkyl; Rk is H, halo, -OH, -NH2, or -NH-C(O)Ci-6alkyl; and R11 is H, Ci-6alkyl, or C3-locycloalkyl.

[0210] In some embodiments of a compound of formula (I-F), Y1 is CH or N; Rx is H, halo, or Ci-6alkyl; Ry is (i) Ci-6alkyl, (ii), C2-6alkenyl, or (iii) Cs-iocycloalkyl, wherein the C3-locycloalkyl is optionally substituted with one or more halo or Ci-6alkyl; Rk is H or halo; and R11 is H, Ci-6alkyl, or Cs ecycloalkyl. In some embodiments, Y1 is N or CH, Rx is H or halo, Ry is Ci-119 ealkyl or C3-6cycloalkyl, Rk is H or halo, and Rn is Ci-6alkyl or C3-6cycloalkyl. In some embodiments, Y1 is N or CH, Rx is H or fluoro, Ry is Ci-6alkyl or C3-6cycloalkyl, Rk is H or fluoro, and R11 is Ci-6alkyl or C3-6cycloalkyl. In some embodiments, Y1 is N or CH, Rx is H or fluoro, Ry is Ci-6alkyl or C3-6cycloalkyl, Rk is H or fluoro, and R11 is Chalky I or C3-6cycloalkyl. In some embodiments, Y1 is N or CH, Rx is H or fluoro, Ry is Ci-6alkyl or C3-6cycloalkyl, Rk is H, and R11 is Ci-6alkyl or C3-6cycloalkyl. In some embodiments, Y1 is N or CH, Rx is H or fluoro, Ry is Ci-3alkyl or C3-6cycloalkyl, Rk is H, and R11 is Ci-31kyl or C3-6cycloalkyl. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0211] In some embodiments of a compound of formula (I-C), (I-D), (I-E), or (I-F), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealkyl, wherein the Ci-ealkyl of R2 is optionally substituted with one or more Ra. In some embodiments, R2 is Ci-ealkyl, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of Ra is optionally substituted with one or more Rb. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl of Ra is optionally substituted with one or more Rb. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl of Ra is optionally substituted with one or more Ci-6alkyl, wherein the Ci-6alkyl is optionally substituted with one or more halo, -NH2, -NH(Ci-ealkyl), -N(Ci-ealkyl)2, -NH-C(O)Ci-ealkyl, or -NH-C(O)-Ci-ealkoxy. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-10 membered heteroaryl, wherein the 510 membered heteroaryl of Ra is optionally substituted with one or more methyl, wherein the methyl is optionally substituted with one or more fluoro. In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0212] In some embodiments of a compound of formula (I-C), (I-D), (I-E), or (I-F), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the In some embodiments, R2 is

[0213] In some embodiments of a compound of formula (I’), (I-C), (I-D), (I-E), or (IF), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the

[0214] In some embodiments of a compound of formula (I’), (I-C), (I-D), (I-E), or (I- F), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is selected from the group consisting of

[0215] In some embodiments of a compound of formula (I’), (I-C), (I-D), (I-E), or (I- F), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is

[0216] In some embodiments of a compound of formula (I-C), (I-D), (I-E), or (I-F), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealkyl, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more Rc. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more oxo or Ci-6alkyl. In some embodiments, R2 is         0     . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0217] In some embodiments of a compound of formula (I’) (I-C), (I-D), (I-E), or (I- F), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is 3-8 membered heterocyclyl, wherein the 3-8 membered heterocyclyl of Ra is optionally substituted with one or more Rc, wherein Rcis oxo, Ci-6alkyl, or -C(O)-Ci-6alkoxy, wherein the Ci-6alkyl of Rc is optionally substituted with one or more halo , and the -C(O)-Ci-6alkoxy of Rc is optionally substituted with one or more halo. In some embodiments, R2 is selected from the and

[0218] In some embodiments of a compound of formula (I-C), (I-D), (I-E), or (I-F), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-ealkyl, wherein the Ci-ealkyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re. In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re, wherein Re is -C(O)-(3-15 membered heterocyclyl). In some embodiments, R2 is O

[0219] In some embodiments of a compound of formula (I’), (I-C), (I-D), (I-E), or (IF), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -O-Re, wherein Re is -C(O)-(3-15 membered heterocyclyl)wherein the -C(O)-(3-15 membered heterocyclyl) of Re is optionally substituted with one or more Ci-ealkyl, wherein the Ci-ealkyl is optionally substituted with one or more halo, Ci-ealkoxy, or C3-iocycloalkyl. In some embodiments, R2 is selected from the group consisting of O

[0220] In some embodiments of a compound of formula (I-C), (I-D), (I-E), or (I-F), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is Ci-6alkyl, wherein the Ci-6alkyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd). In some embodiments, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of Rc and Rd is -C(O)-N(Ci-6alkyl)2. In some embodiments, R2 is 0    . In some variations, the embodiments provided herein also apply to a compound of formula (I’) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or any variation or embodiment thereof.

[0221] In some embodiments of a compound of formula (I’), (I-C), (I-D), (I-E), or (IF), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of Rc and Rd, -C(O)-Ci-6alkyl, -C(O)- N(Ci-6alkyl)2, or -C(O)-(3-15 membered heterocyclyl). In some embodiments, R2 is O ,

[0222] In some embodiments, provided herein is a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt thereof, wherein the compound is a compound of formula (I-G): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein ring A is (i) 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of ring A is optionally substituted with one or more oxo, (ii) 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of ring A is optionally substituted with one or more halo, Ci-6alkyl, C2-6alkenyl, Ci-ealkoxy, -NH2, or Cs-iocycloalkyl, wherein, the Ci-ealkyl is optionally substituted with one or more halo, and the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl, or (iii) Cviocycloalkyl.

[0223] In some embodiments of a compound of formula (I’), (I-G), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, X3 is H, fluoro or methyl optionally substituted with one or more fluoro; X4 is (i) isopropyl (ii) C3-4cycloalkyl optionally substituted with one or more halo or Ci-6alkyl or (iii) butyl; and Rz is fluoro or methyl; provided that at least one of X3 and X4 is halo, CF2 or CF3.

[0224] In some embodiments of a compound of formula (I’), (I-G), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rk is H or halo. In some embodiments of a compound of formula (I-G), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rk is H or fluoro. In some embodiments of a compound of formula (I-G), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, Rk is fluoro.

[0225] In some embodiments of a compound of formula (I’), (I-G), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is 5-20 membered heteroaryl or -(Ci-4alkyl)(5-20 membered heteroaryl), wherein the Ci-4 alkyl is optionally substituted with one or more or more -OH, halo, -NH2, -NH(Ci-6alkyl), -N(Ci-6alkyl)2, and wherein the 5-20 membered heteroaryl is optionally substituted with one or more Rs. In some embodiments, Rs is halo, Ci-6alkyl, Ci-ealkoxy, -NH2, -NH(Ci-6alkyl), -N(Ci-6alkyl)2, -NH-C(O)-Ci-6alkyl, C6-2oaryl, Cs-iocycloalkyl, 3-15 membered heterocyclyl, 5-20 membered heteroaryl, or -C(O)-Ci-6alkoxy. In some embodiments, the Ci-6alkyl of Rs is optionally substituted with one or more halo, Ci-ealkoxy, -NH2, -NH(Ci-ealkyl), -N(Ci-ealkyl)2, -NH-C(O)Ci-ealkyl, or -NH-C(O)-Ci-ealkoxy, and the 3-15-membered heterocyclyl of Rs is optionally substituted with one or more halo or -C(O)-Ci-ealkoxy.

[0226] In some embodiments of a compound of formula (I’), (I-G), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is selected from the group consisting of

[0227] In some embodiments of a compound of formula (I’) (I-G), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, R2 is methyl, wherein the methyl of R2 is substituted with one or more Ra, wherein Ra is -N(Rc)(Rd), wherein one of Rc and Rd is H, and the other of Rc and Rd, -C(O)-Ci-6alkyl, -C(O)-N(Ci-6alkyl)2, or - C(O)-(3-15 membered heterocyclyl). In some embodiments, R2 is O

[0228] In some embodiments of a compound of formula (I’) (I-G), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, ring A is (i) 315 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of ring A is optionally substituted with one or more oxo, or Ci-6alkyl, (ii) 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of ring A is optionally substituted with one or more halo, Ci-6alkyl, C2-ealkenyl, Ci-ealkoxy, -NH2, or C3-iocycloalkyl, wherein, the Ci-ealkyl is optionally substituted with one or more halo, and the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl, or (iii) Cs-iocycloalkyl.

[0229] In some embodiments of a compound of formula (I’), (I-G), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, ring A is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of ring A is optionally substituted with one or more oxo, or Ci-6alkyl,. In some embodiments ring A is selected from the

[0230] In some embodiments of a compound of formula (I’), (I-G), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, ring A is 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of ring A is optionally substituted with one or more halo, Ci-6alkyl, C2-6alkenyl, Ci-ealkoxy, -NH2, or Cs-iocycloalkyl, wherein, the Ci-ealkyl is optionally substituted with one or more halo, and the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl. In some embodiments ring A is 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of ring A is optionally substituted with one or / H T aN more Ci-6alkyl. In some embodiments ring A is selected from the group consisting of    1—J ,

[0231] In some embodiments of a compound of formula (I’), (I-G), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, ring A is C3-locycloalkyl. In some embodiments, ring A is Cs-ecycloalkyl. In some embodiments ring A is cyclopropyl.

[0232] In some embodiments, provided herein is a compound of formula (I’), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt thereof, wherein the compound is a compound of formula (I-H): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Y1 is CRX or N; wherein, when the ring bearing Rx, Ry and Rz is phenyl, Rx, Ry and Rz is H, halo, Ci-6alkyl, C2-6alkenyl, -NH2, -NH-C(O)-(Ci-6alkyl), -NH-C(O)-(3-15 membered heterocyclyl), Cs-iocycloalkyl, or 5-20 membered heteroaryl, wherein the Ci-6alkyl is optionally substituted with one or more halo, -NH-C(O)-NH(Ci-6alkyl), -NH-C(O)-Ci-6alkyl, or -NH-C(O)-Ci-6alkoxy, the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl, and the 5-20 membered heteroaryl is optionally substituted with one or more Ci-6alkyl; and wherein when the ring bearing Rx, Ry and Rz is pyridyl, Rx, Ry and Rz are each indepdently H, halo, Ci-6alkyl, C2-6alkenyl, Ci-ealkoxy, -NH2, or Cs-iocycloalkyl, wherein, the Ci-ealkyl is optionally substituted with one or more halo, and the Cs-iocycloalkyl is optionally substituted with one or more halo or Ci-ealkyl.

[0233] In some embodiments, provided herein is a compound of formula (I), such as a compound of formula (I), (I-A), (I-Al), (I-A2), (I-A3), (I-A4), (I-B), (I-Bl), (I-B2), (I-C), (ID), (I-E), or (I-F), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein R2 is Ci-6alkyl, wherein the Ci-6alkyl of R2 is optionally substituted with one or more Ra. In some embodiments, R2 is Cs-iocycloalkyl, wherein the Cs-iocycloalkyl of R2 is optionally substituted with one or more Rq. In other embodiments, R2 is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of R2 is optionally substituted with one or more halo, oxo, Ci-6alkyl, -C(O)-Ci-6alkyl, or 5-20 membered heteroaryl. In some embodiments, R2 is 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of R2 is optionally substituted with one or more Rs. In some embodiments, R2 is -N(Rg)(Rh), wherein Rg and Rh are independently H or Ci-6alkyl. In some embodiments, R2 is -C(O)-RJ, wherein RJ is C3-locycloalkyl, -NH(Ci-6alkyl), -N(Ci-6alkyl)2, or -NH(5-20 membered heteroaryl). In some embodiments, R2 is C6-2oaryl, wherein the C6-2oaryl of R2 is optionally substituted with one or more 5-20 membered heteroaryl or -O(RP), wherein Rp is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Rp is optionally substituted with one or more -C(O)-Ci-ealkyl.

[0234] In some embodiments, provided herein is a compound of formula (I’), such as a compound of formula (I), (I-A), (I-Al), (I-A2), (I-A3), (I-A4), (I-B), (I-Bl), (I-B2), (I-C), (ID), (I-Dl), (I-D2), (I-E), (I-F), (I-G), or (I-H) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein R2 is Ci-ealky 1, wherein the Ci-ealkyl of R2 is optionally substituted with one or more Ra. In some embodiments, R2 is C3-locycloalkyl, wherein the Cs-iocycloalkyl of R2 is optionally substituted with one or more Rq. In other embodiments, R2 is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of R2 is optionally substituted with one or more halo, oxo, Ci-6alkyl, -C(O)-Ci-6alkyl, or 5-20 membered heteroaryl. In some embodiments, R2 is 5-20 membered heteroaryl, or -(Ci-4alkyl)(5-20 membered heteroaryl), wherein the C1-4 alkyl is optionally substituted with one or more or more -OH, halo, -NH2, -NH(Ci-6alkyl), -N(Ci-6alkyl)2, and wherein the 5-20 membered heteroaryl is optionally substituted with one or more Rs. In some embodiments, R2 is -N(Rg)(Rh), wherein Rg and Rh are independently H or Ci-6alkyl. In some embodiments, R2 is -C(O)-Rj, wherein R> is Cs-iocycloalkyl, -NH(Ci-6alkyl), -N(Ci-6alkyl)2, or -NH(5-20 membered heteroaryl). In some embodiments, R2 is C6-2oaryl, wherein the C6-2oaryl of R2 is optionally substituted with one or more 5-20 membered heteroaryl or -O(RP), wherein Rp is 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Rp is optionally substituted with one or more -C(O)-Ci-6alkyl.

[0235] In some embodiments of a compound of formula (I), or formula (I’), or any variation or embodiment thereof, or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, the compound, or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, is selected from Table 1.

[0236] Compound Names included in Table 1 and for all intermediates and compounds were generated using ChemDraw® Professional software version 17.1.1.0 or Collaborative Drug Discovery Inc. (CDD) CDD Vault update #3.

[0237] A Knime workflow was created to retrieve structures from an internal ChemAxon Compound Registry, generate the canonical smiles using RD Kit Canon SMILES node, remove the stereochemistry using ChemAxon / Infocom MolConverter node, and name the structure using ChemAxon / Infocom Naming node. The following denotes the version of the Knime Analytics Platform and extensions utilized in the workflow: • Knime Analytics Platform 4.2.2 • RD Kit Knime Integration 4.0.1.v202006261025 (this extension includes the RD Kit Canon SMILES node ) • ChemAxon / Infocom Marvin Extensions Feature 4.3.0v202100 (this extension includes the MolConverter node) • ChemAxon / Infocom JChem Extensions Feature 4.3.0v202100 (this extension includes the Naming node) Table 1 Compound No. Structure IUPAC 1 Me^Me o6 HX“ (2S,4R)-l-(2-(lH-l,2,3-triazol-5- yl)acetyl)-4-fluoro-A / -((S)-(4-isopropylphenyl)(phenyl)methyl)py rrolidine-2-carboxamide 2 Me o      □ J     x r A N-^        F Me' (2S ,4R)-4-fluoro-1 - {3 - [N-( 1 -methyl- lH-pyrazol-3-yl)acetamido]propanoyl}-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 3 °' VnJ;0 Me „,F H L / C 0 o „ / "Me Me (2S,4R)-l-[(3aS,6aS)-5-acetyl-hexahydro-lH-furo[3,4-c]pyrrole-3a-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 4 Me^O \           MeMe . 6 p SP F (2S ,4R)-1 - {7-acetyl-1 -oxa-2,7-diazaspiro [4.4] non-2-ene-3 -carbonyl} -4-fluoro-N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 5 .. Me Me~_z 0 0 / --X N'" / [ H F" X^-N^O „ ¥ 0 MeO___X„A„ >< N Me Me Me (2S,4R)-4-fluoro-l-[(2S,3R)-3- methoxy-2-(N-methylacetamido)butanoyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 6 0   0 T x N^Me 0 A, o Me Me (2S, 4R)-1-[(4S, 5R)-7-acetyl- 1-oxo-2,7-diazaspiro [4.4] nonane-4-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 7 0 0 F      ^N. JI r o Me"xxMe (2S, 4R)-1-(2-{2-acetyl-2-azaspiro [3.4] octan-5-yl} acetyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 8 ,0 HN^ / -n^0 F-< 1 H H l F~\J ., ^N. JCxJ O Me^Me (2S,4R)-4-fluoro-l-[(5S)-2-oxo-1,3 -oxazolidine-5-carbonyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 9 Me^Me oO rn N (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -l-[2-(1H-1,2,3,4-tetrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 10 A= . _ / IZ r=\ (D Pd"Oi (2S ,4R)-4-fluoro-1 - [2-(5-methyl-1,3,4-oxadiazol-2-yl)acetyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 11 Me Q^O o °VliH F (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [3 -(lH-l,2,3-triazol-l-yl)propanoyl]pyrrolidine-2-carboxamide 12 V»P » \= / ZI o °=( KZz gV iL (2S ,4R)-4-fluoro-1-(1,3 -oxazole-5-carbonyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 13 Me fl Me (2S ,4R)-1 -(3 -cyanopropano yl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 14 .. Me Me o 0 / ==1 rz- (2S,4R)-4-fluoro-1-(2-methanesulfonylacetyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 15 Me Me oQ Vn " u^j ° o (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(l,3-thiazol-4-yl)acetyl]pyrrolidine-2-carboxamide 16 Me^Me oO r»v ° nJ (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(1H-1,2,4-triazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 17 Me Me oQ f-<7 Vn " N-N 0 nJ (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(2H-l,2,3-triazol-2-yl)acetyl]pyrrolidine-2-carboxamide 18 Me Me oQ ° tNH (2S,4R)-4-fluoro-l-[2-(lH-imidazol-4-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 19 Me Me oO (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(lH-pyrazol-5-yl)acetyl]pyrrolidine-2-carboxamide 20 Me Me oO -oMo 0 n"J-ci (2S ,4R)-1 -[2-(4-chloro-1 H-pyrazol-l-yl)acetyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 21 Me Me HN n 0 ^n"n F (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(pyridazin-3-yloxy)acetyl]pyrrolidine-2-carboxamide 22 Me,,Me oO *0^0 ^N-V 0 nJ (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(IH-pyrazol-l-yl)acetyl]pyrrolidine-2-carboxamide 23 ‘.o-Pc-®  ^=7 ZI / 1 °< A / z iL (2S,4R)-4-fluoro-l-[2-(lH- imidazol-1 -yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 24 MeMe oQ MeAN,N (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -l-[2-(1H-1,2,3,4-tetrazol-1 -yl)propanoyl]pyrrolidine-2-carboxamide 25 Me,,Me oQ -<WO 0 (2S,4R)-4-fluoro-l-(3-methyloxetane-3 -carbonyl)-N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 26 Me^Me oQ -cpO (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(pyrazin-2-yl)acetyl]pyrrolidine-2-carboxamide 27 71 Z— / __ / zz / =\  ® (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(pyrimidin-5 - yl) acetyl] pyrrolidine-2-carboxamide 28 Me Me oO ° o (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(pyrimidin-2- yl) acetyl] pyrrolidine-2-carboxamide 29 ©        zi Z iL (2S ,4R)-4-fluoro-1 - [2-(5-methyl-l,2,4-oxadiazol-3-yl)acetyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 30 • z-^ \__ / o / =°     3 iz / ==\  • (2S ,4R)-4-fluoro-1 -(4-methylpyrimidine-5-carbonyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 31 Me., Me o6 F"<Zfo 0 0>ZMe N (2S ,4R)-4-fluoro-1 - [2-(3 -methyl-l,2,4-oxadiazol-5-yl)acetyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 32 Me Me oQ -oMo H S 0 / 7 O^X^N (2S ,4R)-4-fluoro-1 - [2-(2-oxo-1,2-dihydropyrazin-1 -yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 33 Me.,Me oO - <y« Me^N-N [^N (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(lH-l,2,3-triazol-l-yl)propanoyl]pyrrolidine-2-carboxamide 34 "Tl » Q - d (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(1H-1,2,4-triazol-1 -yl)propanoyl]pyrrolidine-2-carboxamide 35 Me XXo 0 °V^H F (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [3 -(1H-1,2,4-triazol-1 -yl)propanoyl]pyrrolidine-2-carboxamide 36 Me Me oQ o F j F (2S,4R)-4-fluoro-l-[2-(5-fluoropyridin-2-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 37 ©          \ / x--^ yrA,. / <) ■ 1 k, / z iL (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(pyridin-2-yl)acetyl]pyrrolidine-2-carboxamide 38 T1 z— / °5 >°   . __ / zz / =\  ® '■'d''f (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(pyridin-3-yl)acetyl]pyrrolidine-2-carboxamide 39 Me^Me oO "OMp \=N (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(pyridin-4-yl)acetyl]pyrrolidine-2-carboxamide 40 VO' P 1 v° li. (2S ,4R)-4-fluoro-1 - [2-(3 -methyl-l,2-oxazol-5-yl)acetyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 41 °A° . zz / =\ • rd 5 (2S ,4R)-4-fluoro-1 - [2-(2-methyl-1,3 -thiazol-5-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 42 ■)O„P . iL (2S ,4R)-1 -(2-ethyl-1,3 -oxazole-4-carbonyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 43 o * iL (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(IH-pyrazol-l-yl)propanoyl]pyrrolidine-2-carboxamide 44 Me Me oO c& Me^N^ |^N (2S,4R)-4-fluoro-l-[2-(lH-imidazol-1 -yl)propanoyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 45 Me Me'"V--K xxo o F (2S,4R)-4-fluoro-l-[3-(lH-imidazol-5-yl)propanoyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 46 Me Me-^V^ Quo o °v^H ...y-'-AjA, F (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [3 -(lH-pyrazol-4-yl)propanoyl]pyrrolidine-2-carboxamide 47 Me Me^X^^ UCO H      0 CtAq F (2S,4R)-4-fluoro-l-[3-(lH- imidazol-2-yl)propanoyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 48 Me O pVx 7 Me HN _ 0 F (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(pyridin-3-yloxy)acetyl]pyrrolidine-2-carboxamide 49 Me^Me o6 0 l^N-Me (2S ,4R)-4-fluoro-1 - [2-( 1 -methyl-1 H-pyrazol-3 -yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 50 O \== / zi / ■ iL (2S ,4R)-4-fluoro-1 - [2-( 1 -methyl-1 H-pyrazol-4-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 51 WyPo iL (2S ,4R)-4-fluoro-1 - [2-(2-oxo-1,2-dihydropyridin-1 -yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 52 "Tl z— / °"fp = _ / IZ / =\ • rdn- (2S ,4R)-4-fluoro-1 - [2-(2-methyl-1,3 -thiazol-4-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 53 ■>o P 0)  \=J   ZI 5 Ox 1 A ^-2 2 (2S ,4R)-1-(1 -ethyl-1 H-pyrazole-5-carbonyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 54 Me^Me o6 -cMo 0 HN,N^~Me (2S ,4R)-4-fluoro-1 - [2-(3 -methyl-1 H-pyrazol-5-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 55 Me^Me „6 n ' n-n 0 (2S ,4R)-4-fluoro-1 - [2-(3 -methyl-1 H-pyrazol-1 -yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 56 Q \= / ZI / / z iL (2S ,4R)-4-fluoro-1 - [2-(4-methyl-1 H-pyrazol-1 -yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 57 A L^N-Me FAA zNv At ir o Me^Me (2S ,4R)-4-fluoro-1 - [(2S)-1 -methyl-5-oxopyrrolidine-2-carbonyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 58 \ / ® y / W pfvo = u. (2S ,4R)-4-fluoro-1 -(6-oxopiperidine-3-carbonyl)-N- [(S) -phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 59 AA      Me U AAA tj Me HN n 0 F (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [3 -(pyrazin-2-yl)propanoyl]pyrrolidine-2-carboxamide 60 Me O ^v( Me oHV° V F (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [3 -(pyrimidin-5-yl)propanoyl]pyrrolidine-2-carboxamide 61 Me^Me Vf o Q OMe     N '"AAA (1 H A F (2S ,4R)-4-fluoro-1 -(3 -methoxy-1 -methyl- lH-pyrazole-4-carbonyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 62 Me Me^y^y HO 0 °VNH N-N F (2S ,4R)-4-fluoro-1 - [3 -(5-methyl-1,3,4-thiadiazol-2-yl)propanoyl] -N -[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 63 ® \ / 0 ®  \= /  ZI • °< M / z IL (2S,4R)-l-[2-(2-chloro-5-fluorophenyl) acetyl] -4-fluoro-N -[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 64 Me Me oO Me (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(pyridin-2-yl)propanoyl]pyrrolidine-2-carboxamide 65 Me V? fOX Me HN n 0 coX F (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [3 -(pyridin-2-yl)propanoyl]pyrrolidine-2-carboxamide 66 r^\       Me O OVA Me HN n 0 V10 COX F (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [3 -(pyridin-3-yl)propanoyl]pyrrolidine-2-carboxamide 67 o Me 0  °'^''TA_ Me H 0 (2S,4R)-l-{2- [(dimethylcarbamoyl)amino] acetyl} -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 68 Me 0 HN         'Me W ^=0 aw (2S,4R)-l-[2-(lH-l,2,3-benzotriazol-1 -yl)acetyl] -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 69 C \== / ZI / \ IL (2S,4R)-l-[2-(2,5-dimethyl-l,3-thiazol-4-yl)acetyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 70 Me Me ,0 [ Me Me^0 (2S ,4R)-1 - [2-(3,5-dimethyl-1,2-oxazol-4-yl)acetyl] -4-fluoro-N -[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 71 F 0 Me ।—\ Me O^q Me (2S ,4R)-4-fluoro-1 - [2-(N-methylacetamido)propanoyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 72 Me Me oO '■rr H Me (2S,4R)-l-(2-acetamidopyridine-4-carbonyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 73 Me^Me oQ -Yr.. / 0 (2S ,4R)-4-fluoro-1 - [2-(2-oxo-1,2-dihydropyridin-1 -yl)propanoyl] -N -[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 74 .. Me Me o 0 \L / =^ / [ H F" Y\^N J. NH 0 (2S ,4R)-4-fluoro-1 - {3-oxo-2H,3H-[l,2,4]triazolo[4,3-a]pyridine-8-carbonyl} -N - [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 75 Me. „ K-Me a / 0 QA \ 0 (2S,4R)-4-fluoro-l-[4-(lH-imidazol-l-yl)butanoyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 76 Me O OU. Me oHNy° Me-N7^^'^^' H F (2S ,4R)-4-fluoro-1 - [3 -(1 -methyl-1 H-pyrazol-4-yl)propanoyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 77 Me 0 HN         'Me / / to (2S ,4R)-1 - [2-( 1H-1,3 -benzodiazol-l-yl)acetyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 78 N=\        Me^Me 'O. 0 ;a F (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [5-(pyridin-4-yl)- lH-pyrazole-3-carbonyl]pyrrolidine-2-carboxamide 79 Me Me^^. Ho O °V^H n^n^nA Me ’-V F (2S,4R)-4-fluoro-l-[3-(lH-imidazol-1 -yl)-2-methylpropanoyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 80 Me MrO< Ho o V^H \=4 Me O / F (2S ,4R)-4-fluoro-1 - [2-methyl-3 -(1 H-pyrazol-1 -yl)propanoyl] -N -[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 81 Me ., Me o6 -t / n □ CX (2S,4R)-4-fluoro-l-[2-(6- methoxypyridin-2-yl)acetyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 82 3 CD °v / °'z o / -° 3 IZ / =\ • d^1 (2S,4R)-4-fluoro-l-[5- (methoxymethyl)-1,2-oxazole-4-carbonyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 83 Me^Me „6 -cd^O / / VN> 0 ON~Me Me (2S ,4R)-1 - [2-( 1,5-dimethyl-1H-pyrazol-3-yl)acetyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 84 Tl a     z— / CD             \ \= / X Z=°    a iz X O:i:z / =\ / ’ ■ M (2S ,4R)-1 - [2-(3,5-dimethyl-1H-pyrazol-4-yl)acetyl] -4-fluoro-N-[(S)-phenyl[4-(propan-2- yl)phenyl]methyl]pyrrolidine-2-carboxamide 85 Me^Me oO -oCro 0 J ) oxJ (2S,4R)-4-fluoro-l-[2-(2-oxopiperidin-1 -yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 86 H     F o HN / =x Me vJ> (2S ,4R)-4-fluoro-1 - [2-( 1 H-indol-3 -yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 87 s “ 0 IL. (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - {2-[5-(propan-2-yl)-l,2,4-oxadiazol-3-yl] acetyl }pyrrolidine-2-carboxamide 88 Me., Me »0 ■■ov-o OMe (2S,4R)-4-fluoro-l-[2-(4-methoxyphenyl) acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 89 "71 2- / V . iz / =\  • 0 / 40. /  \          0 g 4 W CD (2S,4R)-4-fluoro-l-[2-(3-fluoro-4-methoxyphenyl) acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 90 4 o \  7=°     a \__ / zz / =\  • 0 / \ • '-n vX (2S,4R)-4-fluoro-l-[2-(5-fluoro-2-methoxyphenyl) acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 91 Me Me-^^v uco o '^^Me    V F (2S,4R)-4-fluoro-l-[2-(2-methylphenoxy) acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 92 Me Me oQ ’■<^0 ° o (2S ,4R)-4-fluoro-1 - [2-methyl-2-(pyridin-2-yl)propanoyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 93 Me Me oQ d0 H 0 (2S,4R)-4-fluoro-1-(2- oxopiperidine-4-carbonyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 94 Me, „ y-Me o /   0 C J 0 N (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [4-(pyridin-3-yl)butanoyl]pyrrolidine-2-carboxamide 95 Me, .. yMe o ___    /   0 H T T 0 (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [4-(pyridin-4-yl)butanoyl]pyrrolidine-2-carboxamide 96 j? jCO F \J H rS=\ VyO 0 O Me^\, Me (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(quinolin-6-yl)acetyl]pyrrolidine-2-carboxamide 97 Me C / n ,NH dSxf F (2S ,4R)-4-fluoro-1 -(2-oxo-1,2,3,4-tetrahydroqumoline-7-carbonyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 98 Me J Me oV F (2S ,4R)-4-fluoro-1 - [2-methyl-3 -(pyridin-4-yl)propanoyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 99 Me MeH^, HO 0 °V^H F (2S,4R)-4-fluoro-l-[3-(2-methylpyridin-4-yl)propanoyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 100 Me Me^yA HO 0 %-liH F (2S,4R)-4-fluoro-l-[3-(6-methylpyridin-3 -yl)propanoyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 101 Me MeH^. HO 0 °V*H F (2S,4R)-4-fluoro-l-[3-(5-methylpyridin-2-yl)propanoyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 102 Me Me Ho 0 Xnh ccM F (2S,4R)-4-fluoro-l-[3-(2-methylpyridin-3 -yl)propanoyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 103 / ==^        Me O z^M XAJj Me HN n Me       o Ze; (2S ,4R)-1 -[3-(3,5-dimethyl-1,2-oxazol-4-yl)propanoyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 104 H / =\ hM W“O\° O )—Me Me (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1-(3-{lH-pyrrolo[2,3-b]pyridin-3-yl]propanoyl)pyrrolidine-2-carboxamide 105 Ma „ \_-Me o 0^0 nA    o Me (2S ,4R)-4-fluoro-1 - [4-(2-methyl-1 H-imidazol-1 -yl)butanoyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 106 Me Me-A^ Ao Me     0 %-"H Me              F (2S ,4R)-1 - [3 -(3,5-dimethyl-1H-pyrazol-1 -yl)propanoyl] -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 107 Me^Me AR’ M ^~N Me h (2S, 4R)-1-[2-(4-acetamidophenyl)acetyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 108 F °hA° XvA Me fl vy Me (2S ,4R)-4-fluoro-1 - [4-oxo-4-(pyrrolidin-1 -yl)butanoyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 109 H CQ / =\ hM Xz )—Me Me (2S,4R)-4-fluoro-l-[3-(lH-indol-3-yl)propanoyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 110 Me MeA^x HO 0 Vnn zxX F (2S ,4R)-1 - [3 -(2,6-dimethylpyridin-3 -yl)propanoyl] -4-fluoro-N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 111 F Me H A Ko HN u A /      Me (2S,4R)-4-fluoro-l-{[(2-methylpropyl)carbamoyl] carbonyl} -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 112 0 Me V^O Me^Me (2S ,4R)-1 - {4- [(1 -acetylazetidin-3 -yl)oxy]benzoyl}-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 113 VOP iL (2S,4R)-l-(2-cyclopropyl-2-oxoacetyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 114 r^\       Me Me HN _ 0 Xr^ H              F (2S ,4R)-4-fluoro-1 - [3 -(6-oxo-1,6-dihydropyridazin-3 -yl)propanoyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 115 F Me °HN^0 \ Me V7 X /     Me (2S,4R)-1- [(dimethylcarbamoyl)carbonyl] -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 116 Me, „ K-Me a /   0 h r\_ N ^P"F Q H Me (2S,4R)-l-[2-(4-acetyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)acetyl] -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 117 Me Me oQ (2S,4R)-l-[2-(2,5-dioxoimidazolidin-1 -yl)acetyl] -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 118 \J H "'rNy-O 0 O Me^X, Me (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1-(2-{[ 1,2,4] triazolo[ 1,5-a]pyridin-6-yl} acetyl)pyrrolidine-2-carboxamide 119 GQ o V n~a o HN z=\ Me Mg VJ (2S ,4R)-1 - [2-( 1,2-benzoxazol-3 -yl)acetyl] -4-fluoro-N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 120 Me MeO^v HO o °VNH V Me F (2S ,4R)-4-fluoro-1 - [2-methyl-3 -(1H-1,2,4-triazol-1 -yl)propanoyl] - N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 121 GPP-. 0 HN / =\ Me / = / Gy Me w (2S,4R)-4-fluoro-1-(2- {imidazo[ 1,2-a]pyridin-3 -yl} acetyl)-N - [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 122 o o zz Ao ° o Z^“® o 2 (2S ,4R)-4-fluoro-1 -(3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carbonyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 123 Me Me oO d N (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [3 -(1H-1,2,4-triazol-1 -yl)benzoyl]pyrrolidine-2-carboxamide 124 Me O T Me HN -o y^° 1 / ¾^ Me '—( F (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(pyridin-3-yloxy)propanoyl]pyrrolidine-2-carboxamide 125 = / z iL (2S ,4R)-1 - [2-(3,5-dimethyl-1H-pyrazol-1 -yl) acetyl] -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 126 Me^Me oQ o ,N A-Me H 0 (2S ,4R)-4-fluoro-1 - [2-(5-methyl- 2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 127 Me Me oO F-C^^o Me^N-N Me (2S ,4R)-4-fluoro-1 - [2-(4-methyl-1 H-pyrazol-1 -yl)propanoyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 128 Me 0 HN         'Me mV 1                 F F (2S ,4R)-4-fluoro-1 - [2-(4-fluoro-1 H-indol-1 -yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 129 .. Me Me C) 0   \   __ (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(pyrrolidine-1-sulfonyl) acetyl] pyrrolidine-2-carboxamide 130 b, HN-A.q o ^^y-Me Me (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(quinolin-5-yl)acetyl]pyrrolidine-2-carboxamide 131 F HN-y^ O 0 r— 0 Q Me-X Me (2S ,4R)-4-fluoro-1 - {4-oxo-4H,5H,6H,7H,8H-pyrazolo[ 1,5-a] [ 1,4] diazepine-2-carbonyl} -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 132 Me O rv-< ^===^ / /     Me HN n o ^nY~y^nA Me L- / F (2S ,4R)-4-fluoro-1 - [2-methyl-3 -(pyridin-2-yl)propanoyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 133 Me Me ,6 F"°xp OMe (2S,4R)-l-[2-(2-cyano-4-methoxyphenyl)acetyl] -4-fluoro-N -[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 134 ^NH0 Mex f7 Me       X^J (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1-(3-{lH-pyrrolo[2,3-b]pyridin-5-yl]propanoyl)pyrrolidine-2-carboxamide 135 Me MeW^^K Wo o %-Sh cgM F (2S,4R)-4-fluoro-l-[3-(3- methoxypyridin-2-yl)propanoyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 136 Me^Me oQ £ Me ON Me^N Me (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(1,3,5-trimethyl-1 H-pyrazol-4-yl)acetyl]pyrrolidine-2-carboxamide 137 c< OW W Q Me Me' (2S ,4R)-4-fluoro-1 - [2-( 1 -methyl-1 H-indol-2-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 138 r 00 / o Me          N-Z ft 7=0 ° HN' / Me (2S ,4R)-4-fluoro-1 - [2-(5-methyl-1 H-indol- 3 -yl) acetyl] -N- [(S) -phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 139 °^NH°    ° Me (2S ,4R)-4-fluoro-1 -(3 -oxo-octahydroindolizine-6-carbonyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 140 Me Me oO AA L-N '— AMe 0 (2S ,4R)-1 - [(2R,3R)-1 -acetyl-2-(pyridin- 3 -yl)pyrrolidine- 3 -carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 141 Me^Me oQ -aino 0   7 Me (2S,4R)-l-(4-acetylmorpholine-2-carbonyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 142 F 0 rA Me N y V Me 0 An HN ° ~A      Me f A A / A A /      Me (2S ,4R)-4-fluoro-1 - [2-(N-methylacetamido)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 143 \ / ® yAA K-'xj^r = IL (2S,4R)-1-(1 -acetyl-3 -fluoroazetidine-3-carbonyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 144 O zz / =\ • dw' (2S ,4R)-1 -(1 -acetylpiperidine-4-carbonyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 145 F 0 Me Me^N^A^1 “e °H^° Az      Me (2S ,4R)-4-fluoro-1 - [(2R)-2-(N-methylacetamido)propanoyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 146 “e. - £ F^f'j  H A / pX1 0 / ¼. o Me^Me (2S,4R)-l-(l-acetyl-3-methylazetidine-3-carbonyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 147 y-Me 7 / -N^° FAA r 0 zAs o Me^Me (2S ,4R)-1-( 1 -acetylpyrrolidine-3 -carbonyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 148 Ox Vn£> Ue          / ">'F ^-N 1 0    / ,__„ HN-Z / >—< o v / A=\ M \—Me Ue (2S,4R)-l-[(lS,5S)-3-acetyl-3-azabicyclo[3.1.0]hexane-1 -carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 149 Me Me nS o P F (2S ,4R) -1 - (4- acetylmorpholine- 3 -carbonyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 150 0 A rT^N Me °y / "7, H L / f 1 ..ny^ o o „ / "Me Me (2S,4R)-l-[(lS)-5-acetyl-2-oxa-5-azabicyclo [2.2.1 ]heptane-1 -carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 151 0 Me—Me^Me o N I H : V-' H F (2S ,4R)-1 - {2-acetyl-5-oxa-2,6-diazaspiro [3.4] oct-6-ene-7 -carbonyl} -4-fluoro-N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 152 Me^Me oQ Vn h O Y V-N^o Me (2S,4R)-l-(l-acetyl-3-methylpyrrolidine-3-carbonyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 153 Me^Me ,0 CLo Me (2S,4R)-l-[(3S)-l-acetylpiperidine-3-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 154 » 9 m (2S,4R)-l-[2-(l-acetyl-3-methylazetidin- 3 -yl) acetyl] -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 155 Me^Me oQ Vn o ' \ Me^N^ Y 0 (2S,4R)-l-{2-[(2R)-l-acetylpyrrolidin-2-yl] acetyl} -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 156 0, V-Me Ule Me 4 6 <.U.z4 p bQ F (2S,4R)-l-{5-acetyl-5-azaspiro [2.4]heptane-1 -carbonyl} -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 157 YS     Me Me HN _ 0 F (2S,4R)-l-[(2S)-7-acetyl-7-azabicyclo[2.2. l]heptane-2-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 158 >—'  a 71.          '         • \__ /   O 3 iz   / =\  • (2S ,4R)-1 -[(2R)-4-acetyl-1,4-oxazepane-2-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 159 Me Me o oVV 0 z Me V H u F (2S ,4R)-1 - [(2S ,3R)-4-acetyl-2-methylmorpholine-3-carbonyl] -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 160 0 Me-A "%O C'O Me Me (2S,4R)-l-[2-(4-acetyl-2-oxopiperazin-1 -yl)acetyl] -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 161 Me^Me M| 0 ,, I 41 / x M^n M-f U " n-2 Me MA” ^OMe0 0 (2S,4R)-l-[2-(l-acetyl-3-methoxyazetidin-3-yl)acetyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 162 F C) .—,..,0   N~< H r=\ M >-z yNM ) Me' \v-M    o T'M—' p MeMe (2S,4R)-l-[(2R,3aR,6aR)-5-acetyl-hexahydro-2H-furo[2,3-c]pyrrole-2-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 163 ■^p ©  \= / zx 5 °=( Ox       \ ^2 ° A o^z-J © 2 (2S ,4R)-1 - {2-acetyl-5-oxa-2-azaspiro[3.4]octane-6-carbonyl}-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 164 •>nP a —J zx s °A oK / \ ^-2 r~bo7 o^z-J © 2 (2S ,4R)-1 - {2-acetyl-5-oxa-2-azaspiro [3.4] octane-7-carbonyl} -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 165 Me 0  ^^0    - / N JI J °^NH Me               ? (2S,4R)-l-[(3R,3aS,6aS)-5-acetyl-hexahydro-2H-furo[2,3-c]pyrrole-3-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 166 HN \= / Me ^=0 Me-A0 (2S ,4R)-1 - [(3aR,6S ,6aR)-4-acetyl-hexahydro-2H-furo[3,2-b]pyrrole-6-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 167 yw 111 ° 0 jY > f Me N^J MeA Y N Me o (2S ,4R)-1 - {6-acetyl-5H,6H,7H,8H-pyrido [3,4-b]pyrazine-7-carbonyl} -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 168 Me Me oQ J Me Qro Me (2S, 4R)-1-(1 -acetyl-3 -methylpiperidine- 3 -c arbonyl) -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 169 ■n            3 5 / =V~ / ZI ° o          /  \ (2S ,4R)-1 -(1 -acetylazepane-4-carbonyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 170 a o zA B«‘-\ J o • y— *1 z— \___ / o s zz / =\  • (2S ,4R)-1 - [(3 S ,4R)-1 -acetyl-4-methylpiperidine-3-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 171 s ° iL (2S,4R)-l-{2-[(3S)-l-acetylpiperidin-3 -yl] acetyl} -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 172 Me Me^X^sx ulq 0^Me 0 F (2S ,4R)-1 - [3 -(1 -acetylpyrrolidin-2-yl)propanoyl] -4-fluoro-N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 173 o R\           / Me Ms “’Ov'l F (2S,4R)-l-[(lR,5S,8S)-3-acetyl-3-azabicyclo [3.2.1 ] octane-8-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 174 0  \= / zi o (2S,4R)-l-{6-acetyl-6-azaspiro [2.5] octane-1 -carbonyl} -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 175 F VCH^0 / ^" Me7 W ))HN„ O (2S,4R)-l-{8-acetyl-8-azabicyclo [3.2.1] octane-3 -carbonyl} -4-fluoro-N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 176 Me o Me T L / x / _ NH °V 0    0 Me F (2S ,4R)-1 - [(1S ,4R)-2-acetyl-2-azabicyclo[2.2.2]octane-6-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 177 d> sv° pi- °IZ ,__ 0 j-fv o (2S ,4R)-1 - [(3 aS ,4S ,6aS )-2-acetyl-octahydrocyclopenta[c]pyrrole-4-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 178 Me^Me oQ "■c / pO ^NyO Me (2S,4R)-l-(l-acetyl-2-methylpiperidine- 3 -c arbonyl) -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 179 Mb.Me X o. / 0 o "e Q " iQ F (2S,4R)-l-[(3R,4S)-l-acetyl-4-ethy Ip yrrolidine-3-carbonyl] -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 180 Me Me oQ yO Me^X^x Xn^o Me (2S ,4R)-1 - [2-( 1 -acetylpiperidin-4-yl)propanoyl] -4-fluoro-N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 181 Me.,Me o6 fXo Me\C ^Ny=o Me (2S,4R)-l-(l-acetyl-4-methylazepane-4-carbonyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 182 / ~Q » s iz / =\  ® d (2S,4R)-l-{2-acetyl-2-azaspiro[4.4]nonane-6-carbonyl}-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 183 < O^N^hF H XV O „ / -- Me Me (2S,4R)-l-[(3aS,4R,7aS)-2-acetyl-octahydro- lH-isoindole-4-carbonyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 184 2 / X^0 \__ / o >° 3 XZ 7=\ • (2S,4R)-l-{8-acetyl-8-azaspiro[4.5]decane-2-carbonyl}-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 185 Me xJ] Me KN n Me 0 V10 Me^T^N^X OH F (2S ,4R)-4-fluoro-1 -(2-hydroxy-3 -methylbutanoyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 186 °HN^° x-y~~vV m® w"< V=sZ        Me (2S,4R)-l-(2,3-dihydroxypropanoyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 187 » x 6 O0 / — ® IL IL a 2 2 (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2(2,2,2- trifluoroacetamido)acetyl]pyrrolidi ne-2-carboxamide 188 Me, „ \_-Me a ___    /   0 (2S ,4R)-1 -(2-cyanoacetyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 189 ■> o IL (2S,4R)-l-{2-[N- (carbamoylmethyl)acetamido] acety 1} -4-fluoro-N - [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 190 Me ,. Me oO r HN o Me (2S ,4R)-1 -(3 -acetamidopropano yl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 191 Me Me oO r <;« ■ XNH Me^o (2S,4R)-l-(4-acetamidobutanoyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 192 Me Me „6 cr'' / (2S,4R)-4-fluoro-l-[2-(2-oxopyrrolidin-1 -yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 193 Me Me oQ F<^rc XNH o^AMe (2S,4R)-4-fluoro-l-{2-[(3-methyloxetan-3-yl)amino] acetyl} -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 194 Me^Me 0Q X-N hn^n (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(4H-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide 195 Me Me oO F U n zN (2S ,4R)-4-fluoro-1 - [2-( 1,3 -oxazol-5-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 196 %<vP ■ ®  ^= / zio \ = / z -        / ^o u.       O X (4S)-4-acetamido-5-[(2S,4R)-4-fluoro-2- {[(S )-phenyl[4-(propan-2-yl)phenyl]methyl]carbamoyl]pyrrol idin-1 -yl] -5-oxopentanoic acid 197 ■h> P ■ ©  X= /  21 o \ -         / ==0 u.       O X (4R)-4-acetamido-5- [(2S ,4R)-4-fluoro-2- {[(S )-phenyl[4-(propan-2-yl)phenyl]methyl]carbamoyl]pyrrol idin-1 -yl]-5-oxopentanoic acid 198 T1 2 I O IZ / =\  ® (2S ,4R)-4-fluoro-1 - {2-[( 1,3-oxazol-2-yl)amino] acetyl} -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 199 MeMe „6 Me (lS,3S,5S)-2-acetyl-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl]-2-azabicyclo[3.1.0]hexane-3-carboxamide 200 Me Me .0 0 (lR,3S,5R)-2-acetyl-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl]-2-azabicyclo[3.1.0]hexane-3-carboxamide 201 Me Me oO N'Y'4! Vn H O Me (lS,2S,5R)-3-acetyl-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] - 3 -azabicyclo[3.1.0]hexane-2-carboxamide 202 Me Me oQ U N (2RS ,4R)-4-fluoro-N- [(S )-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(4H-1,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide 203 o IZ / =\  ® (2S)-l-cyclopropanecarbonyl-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 204 z o ■dd . d^- (2S,4S)-l-acetyl-4-hydroxy-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 205 Me^Me „6 Me (2S ,4R)-1 -acetyl-4-hydroxy-N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 206 3 Z- / n_ / \ 3 O xz ,=% ® dOi (2S,3S)-l-acetyl-3-hydroxy-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 207 3 Z-d <D__ /    \ >O 3 o XZ / =\  ® d"° ■ (2S,4R)-l-acetyl-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 208 Ko dlzz^°   S ’ d^ (2S,4R)-l-[(2S)-3-carbamoyl-2-acetamidopropanoyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 209 Me Me oO ■ a / J 0 1        NH, Me-%     2 (2S,4R)-l-[(2R)-3-carbamoyl-2-acetamidopropanoyl]-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 210 Me^Me oO Vn H O r NH °^O Me'Tiui-Me Me tert-butyl N-{2-oxo-2-[(2S)-2-{[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]carbamoyl}pyrrol idin- l-yl]ethyl}carbamate 211 Me^Me oQ / y n'^y^ r OH (2S)-1 -(2-hydroxyacetyl)-N - [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 212 Me^Me oQ Vn h O r NH °^Me (2S)-l-(2-acetamidoacetyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 213 O 2- / — / V / = ® g Z o IZ / => O ' d^' (2S)-l-(3-carbamoylpropanoyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 214 MeMe oO Vn H O / VMe Me ff 0 (2S,5S)-l-acetyl-5-methyl-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 215 Me^Me ,Q uH O . ^Me Me' JI 0 (2S,5R)-l-acetyl-5-methyl-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 216 Z"\ O- / "^   / =°    3 / »   ° IZ / ==\ o dc^ (2S)-l-[2-(l ,3 -oxazol-2-yl)acetyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 217 s o V iL (2S ,4R)-4-fluoro-1 - [2-(2-oxo-1,3-oxazolidin-3 -yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 218 5 o p „ ■ iL (2S,4R)-4-fluoro-l-[2-(oxetan-3-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 219 ■ y-z     o iL (2S,4R)-4-fluoro-l-[2-(3-oxomorpholin-4-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 220 Me Me oC ■■ rr / ( y® V-N [T^N (2S ,4RS )-4-fluoro-1 - [2-( 1 -methyl-1 H-pyrazol-5-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 221 £ o^VJ / z iL (2S,4RS)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(IH-pyrazol-l-yl)acetyl]pyrrolidine-2-carboxamide 222 Z— / / r^ o iz / =. o ■ (2RS ,4R)-4-fluoro-N- [(S )-phenyl[4-(propan-2-yl)phenyl] methyl] - l- [2-(lH-l,2,3-triazol-l-yl)acetyl]pyrrolidine-2-carboxamide 223 Me^Me oQ ■ o £ -NH (2RS ,4R)-4-fluoro-N- [(S )-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(2H-l,2,3,4-tetrazol-5-yl)acetyl]pyrrolidine-2-carboxamide 224 Me^Me oO 0> (2RS ,4R)-4-fluoro-1 - [2-( 1,3,4-oxadiazol-2-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 225 Me Me oO H (2RS ,4R)-4-fluoro-N- [(S )-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-( 1H-pyrazol-3-yl)acetyl]pyrrolidine-2-carboxamide 226 Vo p., e \= / ZI o * / / Z iL (2RS ,4R)-4-fluoro-1 - [2-(5-methyl-1H-1,2,3,4-tetrazol-1 -yl)acetyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 227 T1 / W o iz / =, o ■ d (2RS ,4R)-4-fluoro-1 - [2-(4-methyl-4H-l,2,4-triazol-3-yl)acetyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 228 Vo P . ■ -V-P iL (2RS ,4R)-4-fluoro-1 - [2-( 1 -methyl-1H-1,2,3 -triazol- 5 -yl) acetyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 229 Me ., Me oQ X-n F "n Me (2RS ,4R)-4-fluoro-1 - [2-( 1 -methyl-lH-l,2,3-triazol-4-yl)acetyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 230 Me., Me o6 [f^N ^0' (2S ,4R)-4-fluoro-1 - [2-( 1,2-oxazol-4-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 231 P , 5         / ZX° C '° E ©= / / z iL (2S ,4R)-4-fluoro-1 - [2-( 1,2-oxazol-3 -yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 232 2- / ^ >O g ' U O IZ / =. <D j d^ (2S ,4R)-4-fluoro-1 - [2-(3 -methyl-lH-l,2,4-triazol-5-yl)acetyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 233 Me., Me „6 '■•Wo Me- / rf / N (2S ,4R)-4-fluoro-1 - [2-methyl-2-(1H-1,2,4-triazol-5-yl)propanoyl] - N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 234 Me Me .6 X-NH (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl] methyl] -1 - [2-(piperazin-1 - yl)acetyl] pyrrolidine-2-carboxamide 235 Me Me oO >#0 0 (2S,4R)- l-[2-(4-acetylpiperazin-1-yl)acetyl] -4-fluoro-N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 236 Me^Me oQ XVm6 CT o (2S ,4R)-4-fluoro-1 - [2-(5-methyl-2-oxo-2,3-dihydro-1,3,4-oxadiazol-3-yl)acetyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 237 Me Me ,6 X-0 II n'n^ ,9 N HN~< Me O-^-Me Me tert-butyl N-[(5-{2-[(2S,4R)-4-fluoro-2- {[(S )-phenyl[4-(propan-2-yl)phenyl]methyl]carbamoyl]pyrrol idin-1 -yl] -2-oxoethyl )-1,3,4-oxadiazol-2-yl)methyl] carbamate 238 Me^Me oQ u H IJ Vs-0 Vo II \_____. V \ N nh2 (2S ,4R)-1 - {2- [5-(aminomethyl)-1,3,4-oxadiazol-2-yl] acetyl} -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 239 P X ®   X= / ZI o \ / / Z iL (2S,4R)-l-{2-[5- (acetamidomethyl)-1,3,4-oxadiazol-2-yl] acetyl }-4-fluoro-N-[(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 240 Me Me o6 ,N, J N" H2N (2S ,4R)-1 - {2- [5-(aminomethyl)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 241 Me Me ,0 xx ,N, J N" Me-N Me (2S,4R)-l-(2-{5- [(dimethylamino)methyl]- 1H-1,2,3-triazol-1 -yl} acetyl)-4-fluoro-N -[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 242 Me^Me 06 V-o Ji \_____. N N-Me Me (2S,4R)-l-(2-{5- [(dimethylamino)methyl] -1,3,4-oxadiazol-2-yl} acetyl)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 243 Me^.Me 06 J N' hx y—nh Me7 (2S,4R)-l-{2-[5- (acetamidomethyl) -1H-1,2,3-triazol-1 -yl] acetyl} -4-fluoro-N -[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 244 - £                 ft F / z lL (2S4 / <)-H2-(lH-l,2,3-triazol-5-yl)acetyl)-4-fluoro-A / -((S)-(5-isopropylpyridin-2-yl)(phenyl)methyl)pyrrolidine-2-carboxamide 245 o zz / =\ ® d^’ (2S)-1 -acetyl-N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 246 ■> o Pv ® \= / zi o ^F1 o=< Vz \ k'j     * (2S ,4R)-1 - [2-(3,5-dimethyl-1H-pyrazol-4-yl)acetyl] -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 247 Me Me oa f r \^N (2S,4R)-4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]-l-[2-(quinolin-5-yl)acetyl]pyrrolidine-2-carboxamide 248 hc>p . s      719 L_ / A a     O=^ / z iL (2S ,4R)-1 - [2-( 1H-1,3 -benzodiazol-l-yl)acetyl]-4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 249 ®  X= / ZI o '  21 s     o=( ° iL (2S ,4R)-4-fluoro-1 - [2-(5-methyl-2,4-dioxo-l,2,3,4-tetrahydropyrimidin-1 -yl)acetyl] -N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 250 Me^Me oQ \h O*^N,Me Me (2S,4R)-l-{2- [(dimethylcarbamoyl)amino] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 251 Me^Me .6 O^N,Me Me 2-[(2S,4R)-4-fluoro-2-{ [(S)-phenyl[5-(propan-2-yl)pyridin-2-yl] methyl] carb amoyl} pyrrolidin-1 -yl]-2-oxoethyl N,N-dimethylcarbamate 252 Me Me oQ V" N N (2S,4R)-4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]- 1 - [2-( 1H-1,2,3,4-tetrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 253 E     o= / / Z iL (2S ,4R)-1 - {2- [5-(difluoromethyl)-1,3,4-oxadiazol-2-yl] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridm-2-yl]methyl]pyrrolidine-2-carboxamide 254 ■>o P ,. 2 O=<    __ / Z~A ■L (2S ,4R)-1 - {2- [5-(difluoromethyl)-1H-1,2,3,4-tetrazol-1 -yl] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 255 T1 n z-z /      / =°     g \ / / ' o zz / =. o ■■■ (2S,4R)-4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]- 1 - {2- [5 - (trifluoromethyl) -2H-l,2,3,4-tetrazol-2-yl] acetyl }pyrrolidine-2-carboxamide 256 T1 ■n            '°     3 \     ' O iz / =. o ■ ■ d'°^ (2S ,4R)-1 - {2- [5-(difluoromethyl)-2H-1,2,3,4-tetrazol-2-yl] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 257 Tl s / ¾     z—< ®^Z \   ,__✓  \ \\             )=°      g ° d ° '■ (2S,4R)-4-fluoro-l-[2-(2-methylquinolin-5-yl)acetyl] -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 258 i-z z^ZA_ X        )=O    3 \\ o IZ / —.   n d (2S ,4R)-4-fluoro-1 -(2- {3 -oxo-2H,3H-[l,2,4]triazolo[4,3- a] pyridin- 8 - yl} acetyl) -N- [(S) -phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 259 Me x. Me oQ -aim zNMe Me (2S ,4R)-1 - {2-[4-(dimethylamino)-2H-1,2,3 -triazol-2-yl] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 260 Me^Me oO“ VN M 'N'Me MO (2S ,4R)-1 - {2-[4-(dimethylamino)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 261 "ri O ^ZZ \ S ^z? W X®    g ®~Z X  Oiz / =,  ® ' d (2S,4R)-4-fluoro-l-{2-[(methylcarbamoyl)amino] acetyl} -N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 262 T1 O ^ / Z \ Xz / ~X X°    g ' dCK' (2S,4R)-l-[2- (carbamoylamino)acetyl]-4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 263 Me ,, Me o Q -cfro V-NH N >=O 'N Me (2S ,4R)-4-fluoro-1 - [2-( 1 -methyl-5 -oxo-4,5-dihydro- 1H-1,2,4-triazol-3-yl)acetyl] -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 264 Me Me 1 ,Me N ™ N H (2S ,4R)-4-fluoro-1 - [2-(4-methyl-5 -oxo-4,5-dihydro- 1H-1,2,4-triazol-3-yl)acetyl] -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 265 Uy 'P □ ® x= / zi o X E    O=( V^Z^ / ^2     ° iL (2S ,4R)-1 - {2- [(azetidine-1 -carbonyl)amino] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 266 Me Me 0 O1 F<itrc X^o N " N Me (2S ,4R)-4-fluoro-1 - [2-(4-methyl-5 -oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetyl] -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 267 ®   ^=7 zi o \ / S       ^>=z / z iL (2S ,4R)-4-fluoro-1 - [2-(4-methyl-5 -oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)acetyl] -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 268 ■, O Ru ®      «oiL i z / Z LL (2S,4R)-4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]-1 - {2- [4- (trifluoromethyl) -1H-1,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide 269 kp . ®  ^=7 ZX o X Z^ >”Z      '— / IL. (2S,4R)-4-fluoro-l-{2-[(2-methylpyrimidin-4-yl)amino] acetyl} -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 270 5 O- P IL. (2S ,4R)-4-fluoro-1 - [2-( 1,3 -oxazol-2-yl)acetyl] -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 271 Me^Me 0Q rO"p r 0 N^~Me (2S ,4R)-4-fluoro-1 - [2-(5-methyl-l,3-oxazol-2-yl)acetyl]-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 272 Me^Me oQ Me (2S ,4R)-4-fluoro-1 - [2-(4-methyl-l,3-oxazol-2-yl)acetyl]-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 273 Me^Me ,Q Me NH cON-Me Me (2S,4R)-l-[(2S)-2- [(dimethylcarbamoyl)amino]propan oyl]-4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 274 Me^Me 0Q r -G c Me'‘ NH O^N-Me Me (2S,4R)-l-[(2R)-2- [(dimethylcarbamoyl)amino]propan oyl]-4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 275 Me^Me oG 1      Me o^o (2S ,4R)-4-fluoro-1 - [2-(5-methyl-2-oxo-2,3-dihydro-1,3,4-oxadiazol-3-yl)acetyl] -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 276 ■n 2-^ / =°     a ?    012   / =\  ® (2S ,4R)-1 - {2-[4-(azetidin-1 -yl)-2H-1,2,3 -triazol-2-yl] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 277 ■n 2— )=°     a ?    OIZ / =\  • J (2S,4R)-l-{2-[4-(3,3- difluoroazetidin-1 -yl)-2H-1,2,3-triazol-2-yl] acetyl} -4-fluoro-N -[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 278 ■71 2-^ • -, -J       / °       3 /         oiz / =x  ® r d (2S ,4R)-1 - {2- [4-(diethylamino)-2H-1,2,3 -triazol-2-yl] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 279 Me Me oa UM <N HN'N (1S ,2S ,5R)-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]-3-[2-(lH-l,2,3-triazol-5-yl)acetyl]-3-azabicyclo [3.1.0]hexane-2-carboxamide 280 Me Me oQ u H O Me r ™4N (2S ,5S )-5-methyl-N - [(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 281 "Tl X-z'      / =°     g / —z 1  ° Iz  r,—a  • N-{2-[(2S,4R)-4-fluoro-2-{ [(S)-phenyl[5-(propan-2-yl)pyridin-2-yl] methyl] carb amoyl} pyrrolidin-1 -yl]-2-oxoethyl}-4-(2,2,2-trifluoroethyl)piperazine-1 -carboxamide 282 p n / \IO x < j s     o=( A_ r-z     ° ■L 4-(cyclopropylmethyl)-N- {2-[(2S,4R)-4-fluoro-2-{[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl] methyl] carb amoyl} pyrrolidin-1 -yl]-2-oxoethyl]piperazine-1-carboxamide 283 Me^Me oG XNH Me N-{2-[(2S,4R)-4-fluoro-2-{ [(S)-phenyl[5-(propan-2-yl)pyridin-2-yl] methyl] carb amoyl} pyrrolidin-1 -yl] -2-oxoethyl} -4-methylpiperazine-1 -carboxamide Me Me 284 - / 3.-P A ^= /  ZIO  \=g °=Z P z iL (2S ,4R)-4-fluoro-1 - [2-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)acetyl] -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide Me x. Me 285 ,-. \= / zio o= /   — / p z iL (2S,4R)-4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]-l-[2-(4H-1,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide Me Me 286 P o °K / z iL (2S ,4R)-4-fluoro-1 - [2-(5-oxo-4,5-dihydro-l,2,4-oxadiazol-3-yl)acetyl] -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide Me Me 287 "71 z—( > ° OIZ\ / =\ (2S,4R)-4-fluoro-l-[3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propanoyl] -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide HN—z 0 288 Me =, Me 0Q IN O^N (2S ,4R)-4-fluoro-1 - [2-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-4-yl)acetyl] -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 289 Me^-Me o O o___N 1 N 0 (2S,4R)-4-fluoro-1-(3-{3-oxo-2H,3H-[l,2,4]triazolo[4,3-a]pyridin-2-yl}propanoyl)-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 290 Me., Me o6 -aim \h O^N-l L-\-F F (2S,4R)-l-{2-[(3,3- difluoroazetidine-1 -carbonyl)amino] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 291 "71 z—( V    >°   3 / ? oiz ,=. o 2’ d^ (2S,4R)-4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]-1 -(2- {[3-(trifluoromethyl)azetidine-1- carbonyl] amino} acetyl)pyrrolidine-2-carboxamide 292 u-,d O ^=7 ZZO z-V E     o=Z V- z ■L (2S,4R)-4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]-1 - [2-( 1 H-pyrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 293 ' ajo Vn r A -N N F (2S,4R)- / V-((S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl)-l-(2-(5-(difluoromethyl)- 1H-tetrazol-1 -yl)acetyl)-4-fluoropyrrolidine-2-carboxamide 294 X= / / ZZ° z—ey / z u. (2S ,4R)-1 - [2-( 1H-1,3 -benzodiazol-1 -yl)acetyl] -N-[(S)-(5 -cycloprop yl-6-fluoropyridin-2-yl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 295 -■airo °*MO H 0 (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl]pyrrolidine-2-carboxamide 296 ofr >N N (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - [2-(4H-1,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide 297 N" hm-4 0 (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-(2-{3-oxo-2H,3H-[l,2,4]triazolo[4,3-a]pyridin-8-yl} acetyl)pyrrolidine-2-carboxamide 298 V” Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [5-(dimethylamino)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 299 A ^n-n V M^N'Me MB (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [4-(dimethylamino)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 300 \h O^N,Me Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-{2- [(dimethylcarbamoyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 301 «&F -'<670 \h °^NH Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-{2-[(methylcarbamoyl)amino] acetyl }p yrrolidine-2-carboxamide 302 ,&F <■70 \h °^nh2 (2S,4R)-l-[2- (carbamoylamino)acetyl]-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 303 . & V-NH N W'N Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - [2-( 1 -methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide 304 A ( Me V-N N n'N H (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide 305 A '•<ddo \h °x”a (2S ,4R)-1 - {2- [(azetidine-1 -carbonyl)amino] acetyl} -N- [(S )-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 306 V-o N *'N Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetyl]pyrrolidine-2-carboxamide 307 A <F~hF (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - {2- [4-(trifluoromethyl)-lH-l,2,3-triazol-5-yl] acetyl }pyrrolidine-2-carboxamide 308 . j- knh d N^Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - {2- [(2-methylpyrimidin-4-yl)amino] acetyl }pyrrolidine-2-carboxamide 309 A ^NH O^N (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - {2- [(1,3 -oxazol-2-yl)amino] acetyl }pyrrolidine-2-carboxamide 310 A' F"< / m yO Me^NH O^N,Me Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-[(2S)-2-[(dimethylcarbamoyl)amino]propan oyl] -4-fluoropyrrolidine-2-carboxamide 311 cr^-Me Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-[(2R)-2-[(dimethylcarbamoyl)amino]propan oyl] -4-fluoropyrrolidine-2-carboxamide 312 •Js' V-o ii \ (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(l,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 313 .&F r° N^~Ue (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - [2-(5-methyl-1,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 314 ,&F V-o ■Q Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - [2-(4-methyl-1,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 315 A knh °^Nn \^F F (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [(3,3 -difluoroazetidine-1 -carbonyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 316 .j- oxyMe (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(5-methyl-2-oxo-2,3-dihydro-1,3,4-oxadiazol-3 -yl)acetyl]pyrrolidine-2-carboxamide 317 yN riy (2S ,4R)-1 - {2-[4-(azetidin-1 -yl)-2H-l,2,3-triazol-2-yl]acetyl}-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 318 o&' yN iiy (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2-[4-(3,3-difluoroazetidin-1 -yl)-2H-1,2,3 -triazol-2-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 319 N ^Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [4-(diethylamino)-2H-1,2,3-triazol-2-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 320 l4?P V (lS,2S,5R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-3-[2-(lH-1,2,3-triazol-5-yl)acetyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide 321 3 zZ z-Z^ / =° 2 \\   ° IZ   z=\ * (2S,5S)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-5 -methyl- l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 322 Me x. Me aF 0 V" 7 N f3c'^ / (2S,4R)-4-fluoro-A^((S)-(3-fluoro-4- isopropylphenyl)(phenyl)methyl)-l-(2-(5-(trifluoromethyl)- 1H-1,2,3-triazol-1 -yl)acetyl)pyrrolidine-2-carboxamide 323 Me^Me ( J 0 Vn H L J Me r hn'n (2S,5S)-N-[(S)-[3-fluoro-4- (propan-2-yl)phenyl] (phenyl)methyl] -5-methyl-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 324 Me^-Me . / L / F ( J 0 (lS,3S,5S)-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -2- [2-(lH-l,2,3-triazol-5-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carboxamide 325 Me Me zL / F ( T 0 ■^rc hi4" (lS,2S,5R)-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -3 - [2-(lH-l,2,3-triazol-5-yl)acetyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide 326 Me^Me a 0 UM ,N HN'N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 327 OF 0 >r "inM Me OH (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1-(2-hydroxy-2-methylpropanoyl)pyrrolidine-2-carboxamide 328 Me Me \=N HN-NN (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(1H-1,2,3,4-tetrazol-5-yl)acetyl]pyrrolidine-2-carboxamide 329 MeMe ( J 0 F,..n Vn h IJ \^n UN N HN'N (2S ,4R)-4-fluoro-N - [(R)- [3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(1H-1,2,3,4-tetrazol-5-yl)acetyl]pyrrolidine-2-carboxamide 330 Me., Me U^F ( J 0 ’’<o 'A Nv (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -l-[2-(1H-1,2,3,4-tetrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 331 Me x. Me aF o r FA NV (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(lH-l,2,3-triazol-l-yl)acetyl]pyrrolidine-2-carboxamide 332 Me. Me JL / f C j 0 >r -cffo \=N 0^N Me (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(5-methyl-1,3,4-oxadiazol-2-yl)acetyl]pyrrolidine-2-carboxamide 333 Me.. .Me F ( J 0 V / V-sN O^N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [ 1 -(1,3,4-oxadiazol-2-yl)cyclopropanecarbonyl]pyrrolidin e-2-carboxamide 334 Mex___,Me ( J 0 F^ro Me Me / \=NS O^N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-methyl-2-( 1,3,4-oxadiazol-2-yl)propanoyl]pyrrolidine-2-carboxamide 335 Me., Me aF 0 Me' N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] - l-[2-(l-methyl-1H-1,2,3 -triazol- 5 -yl)acetyl]pyrrolidine-2-carboxamide 336 Me Me aF 0 >r m. ,N-Me n'N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] - l-[2-(l-methyl- 1H-1,2,3-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide 337 Me ., Me .a F<^ro Me'N'N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] - l-[2-(l-methyl-lH-pyrazol-5-yl)acetyl]pyrrolidine-2-carboxamide 338 Me^Me ^xL.F ( J 0 (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(1,2-oxazol-5-yl)acetyl]pyrrolidine-2-carboxamide 339 MeMe U^F ( J o -adfc N"X^.O Me (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(4-methyl-2,5 -dioxopiperazin-1 -yl)acetyl]pyrrolidine-2-carboxamide 340 n " d M (2S,4R,5S)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -5-methyl-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 341 Me Me J^F ( J o aA^A A (5S)-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -4- [2-(lH-l,2,3-triazol-5-yl)acetyl]-4-azaspiro [2.4] heptane-5 -carboxamide 342 Me., Me U^F ( J 0 vN (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(pyridazin-4-yl)acetyl]pyrrolidine-2-carboxamide 343 Me x. Me a 0 N J (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(pyridazin-3-yl)acetyl]pyrrolidine-2-carboxamide 344 Me Me ( J 0 V^N N J (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(pyrazin-2-yl)acetyl]pyrrolidine-2-carboxamide 345 Me Me a 0 >< < 7N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(pyrimidin-5 - yl) acetyl] pyrrolidine-2-carboxamide 346 Me Me aF 0 n^n (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(pyrimidin-4- yl) acetyl] pyrrolidine-2-carboxamide 347 MeMe ^xL,F ( J 0 \^N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(pyridin-4-yl)acetyl]pyrrolidine-2-carboxamide 348 Me Me Cf 0 (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(pyridin-3-yl)acetyl]pyrrolidine-2-carboxamide 349 Me x. Me .a N 'J (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(pyridin-2-yl)acetyl]pyrrolidine-2-carboxamide 350 Me Me a 0 F< / ro nQ Me (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] - l-[2-(l-methyl-lH-pyrazol-3-yl)acetyl]pyrrolidine-2-carboxamide 351 Me^Me a o 1 Me Me^N' Me (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(1,3,5-trimethyl-1 H-pyrazol-4-yl)acetyl]pyrrolidine-2-carboxamide 352 Me^,Me a 0 N-^Me °XnX H 0 (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl]pyrrolidine-2-carboxamide 353 Me^.Me .a N^_.Me °^nA / 0 Me (2S ,4R)-1 - [2-(3,5-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl] -4-fluoro-N- [(S)- [3 -fluoro-4-(propan-2-yl)phenyl](phenyl)methyl]pyrrolidi ne-2-carboxamide 354 Me^Me a O ¢7 (2S ,4R)-1 - [2-( 1H-1,3 -benzodiazol-1 -yl)acetyl] -4-fluoro-N- [(S)- [3 -fluoro-4-(propan-2-yl)phenyl](phenyl)methyl]pyrrolidi ne-2-carboxamide 355 Me^Me aF 0 Fn Me (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] - l-[2-(l-methyl- lH-pyrazol-4-yl)acetyl]pyrrolidine-2-carboxamide 356 Me Me a O iuLn a (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1-(2-{imidazo[ 1,2-a]pyridin-3 -yl} acetyl)pyrrolidine-2-carboxamide 357 Me Me a o y^O <yj / (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(quinolin-6-yl)acetyl]pyrrolidine-2-carboxamide 358 Me., Me u 0 nA, J, N N^ / (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1-(2-{[ 1,2,4] triazolo[ 1,5-a]pyridin-6-yl} acetyl)pyrrolidine-2-carboxamide 359 Me^Me a o -aV-o N-N R A ‘N >r n F> (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl] -1 - {2-[5-(trifluoromethyl)- 1H-1,2,3,4-tetrazol-1 -yl] acetyl }pyrrolidine-2-carboxamide 360 Me.,Me & o ><0 % O^N-Me Me 2-[(2S,4R)-4-fluoro-2-{ [(S)-[3- fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] carbamo yl Jpyrrolidin-1 -yl] -2-oxoethyl N,N-dimethylcarbamate 361 Me^.Me a 0 ’<-X 'nh O^N_Me Me (2S,4R)-l-{2- [(dimethylcarbamoyl)amino] acetyl} -4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl](phenyl)methyl]pyrrolidi ne-2-carboxamide 362 Me^Me a 0 '<t-X VMe O^N_Me Me (2S,4R)-l-{2- [(dimethylcarbamoyl)(methyl)amin o] acetyl} -4-fluoro-N- [(S)- [3 -fluoro-4-(propan-2-yl)phenyl](phenyl)methyl]pyrrolidi ne-2-carboxamide 363 O    2-( Xo'      / =°     3 ^■2      Oxz / =. g> 2-[(2S,4R)-4-fluoro-2-{ [(S)-[3- fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] carbamo yl Jpyrrolidin-1 -yl] -2-oxoethyl piperazine-1 -carboxylate 364 Me Me ( T 0 o PNyO °yMe Me Me 1 -tert-butyl 4-{2-[(2S,4R)-4-fluoro-2-{ [(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] carbamo yl Jpyrrolidin-1 -yl] -2-oxoethyl} piperazine-1,4-dicarboxylate 365 Mex.Me a o \h P-NH N-{2-[(2S,4R)-4-fluoro-2-{[(S)-[3-fluoro-4-(propan-2-yljphenyl] (phenyl)methyl] carbamo yl}pyrrolidin-l-yl]-2-oxoethyl} piperazine-1 -carboxamide 366 $ •  X= / ZlQ x z~_z iL tert-butyl 4-({2-[(2S,4R)-4-fluoro-2-{ [(S)-[3-fluoro-4-(propan-2-yljphenyl] (phenyl)methyl] carbamo yl Jpyrrolidin-1-yl]-2-oxoethyl} carbamo yljpiperazine-1 -carboxylate 367 Me Me a o T Me HN> (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yljphenyl] (phenyl)methyl] -1 - [2-(4-methyl-1H-1,2,3 -triazol- 5 -yl)acetyl]pyrrolidine-2-carboxamide 368 Me Me a 0 rF4-F UM -N HN'N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] - l- {2-[4-(trifluoromethyl)- 1H-1,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide 369 Me^Me a o V-NH X-N I^N^N HN V (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] - l- {2-[4-(piperazin- l-yl)-lH-l,2,3-triazol-5-yl] acetyl }pyrrolidine-2-carboxamide 370 Me^Me aF 0 V-NH IOn Me^.0 Me^ Me tert-butyl 4-(5-{2-[(2S,4R)-4-fluoro-2-{[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl] carbamo yl Jpyrrolidin-1 -yl] -2-oxoethyl} -1H-1,2,3-triazol-4-yl)piperazine-1 -carboxylate 371 Me^^Me a 0 FVro Vnh Jl n ^n^n °v (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] - l- {2-[4-(morpholin-4-yl)- 1H-1,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide 372 T1 Z \ -n / -2^^   / =°     3 \  7 /  '   OlZ   7=\   ® d "9 '• (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] - l- {2-[4-(trifluoromethyl)- 1H-1,2,3-triazol-1 -yl] acetyl }pyrrolidine-2-carboxamide 373 Me^-Me aF 0 ■aye V" Me (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(4-methyl- 1H-1,2,3-triazol-1-yl)acetyl]pyrrolidine-2-carboxamide 374 Me^Me a 0 ■Yrc ^n-n I N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(5-methyl- 1H-1,2,3-triazol-1-yl)acetyl]pyrrolidine-2-carboxamide 375 Me^Me a 0 •<C-X VN Q H (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] - l- {2-[4-(piperazin-1 -yl)- 1H-1,2,3-triazol-1 -yl] acetyl }pyrrolidine-2-carboxamide 376 Me^^Me aF o r n-n 1 VS Ny 0 H (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] - l- {2-[4-(piperazin-1 -yl)-2H-1,2,3-triazol-2-yl] acetyl }pyrrolidine-2-carboxamide 377 Me^,Me aF 0 N'N (^N M( / N'Me Me (2S ,4R)-1 - {2-[4-(dimethylamino)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl](phenyl)methyl]pyrrolidi ne-2-carboxamide 378 Me ., Me a o F . / v nZ~Y^ Vn h IJ r nJ ..^N'Me Me (2S ,4R)-1 - {2-[4-(dimethylamino)-2H-1,2,3 -triazol-2-yl] acetyl} -4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl](phenyl)methyl]pyrrolidi ne-2-carboxamide 379 Me., Me a o Nx HrH 0 (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl] - l-(2-{3-oxo-2H,3H-[l,2,4]triazolo[4,3-a]pyridin-8-yl} acetyl)pyrrolidine-2-carboxamide 380 Me ., Me a o >r [^N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(IH-imidazol-l-yl)acetyl]pyrrolidine-2-carboxamide 381 Me^,Me .a jG"2 0Anh (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methy 1] -1-[(5S)-2-oxo-1,3 -oxazolidine-5-carbonyl]pyrrolidine-2-carboxamide 382 Me^.Me cP 0 0 > 0Anh (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl] -1 - [(5R)-2-oxo-1,3 -oxazolidine-5-carbonyl]pyrrolidine-2-carboxamide 383 ®  x= / “o U / \. S     0=^ / z iL (2S ,4R)-1 - {2- [5-(difluoromethyl)-1,3,4-oxadiazol-2-yl] acetyl} -4-fluoro-N-[(S)-[3-fluoro-4-(propan- 2- yl)phenyl](phenyl)methyl]pyrrolidi ne-2-carboxamide 384 Me x. Me (p 0 >r k N n' (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(4H-1,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide 385 Me Me .i" •gO~o (2S,4R)-l-(2-(l / / -l,2,3-triazol-5-yl)acetyl)-4-fluoro-A / -((S)-(6-fluoro-5-isopropylpyridin-2-yl)(phenyl)methyl)pyrrolidine-2-carboxamide 386 o P 3          )=°     3 ®~z  \ Oiz / =, o (2S ,4R)-1 - [2-(3,5-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-l-yl)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 387 Me^Me fr VsN Me (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(2-methylquinolin- 5 -yl)acetyl]pyrrolidine-2-carboxamide 388 iz \ O ZZ / =, m d (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl]pyrrolidine-2-carboxamide 389 Me^Me ofr 6N (2S ,4R)-1 - [2-( 1H-1,3 -benzodiazol-l-yl)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 390 Me Me ofr 1« N N (2S ,4R)-4-fluoro-N - [(S)- [6-fluoro-5-(propan-2-yl)pyridin-2- yl] (phenyl)methyl] -1 -[2-(4H-1,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide 391 Me^Me ofr F"OiaXo HK 0 (2S ,4R)-4-fluoro-N - [(S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 -(2- {3 -oxo-2H,3H-[l,2,4]triazolo[4,3-a]pyridin-8-yl} acetyl)pyrrolidine-2-carboxamide 392 Me^Me ofr vn Ny Mo / N'Me Me (2S ,4R)-1 - {2-[4-(dimethylamino)-2H-1,2,3 -triazol-2-yl] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2- yl] (phenyl)methyl]pyrrolidine-2-carboxamide 393 Me^Me ofr V" (^N u^'Me Me (2S ,4R)-1 - {2-[4-(dimethylamino)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2- yl] (phenyl)methyl]pyrrolidine-2-carboxamide 394 Me^Me ofr \h O^N_Me Me (2S,4R)-l-{2- [(dimethylcarbamoyl)amino] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 395 Me^Me ofr 'NH °^NH Me (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - {2-[(methylcarbamoyl)amino] acetyl }p yrrolidine-2-carboxamide 396 Me^Me ofr 'nh °^nh2 (2S,4R)-l-[2- (carbamoylamino)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 397 Ms .,Me ofr XnH N £=0 N Me (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro- 5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-( 1 -methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol- 3-yl)acetyl]pyrrolidine-2-carboxamide 398 Me^Me oU ( y® V-N N ^==° N N H (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide 399 Q> P □ o X= / ZIo I z—1 s     o= / O lL (2S ,4R)-1 - {2- [(azetidine-1 -carbonyl)amino] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 400 Me Me ofr ¥" F. X -N rX^N F (2S ,4R)-1 - {2- [5-(difluoromethyl)-1H-1,2,3,4-tetrazol-1 -yl] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan- 2-yl)pyridin-2- yl] (phenyl)methyl]pyrrolidine-2-carboxamide 401 Me .,Me oM "<0^ v-o N ^=° N N Me (2S ,4R)-4-fluoro-N - [(S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(4-methyl-5-oxo-4,5-dihydro-l,3,4-oxadiazol-2-yl)acetyl]pyrrolidine-2-carboxamide 402 Me .,Me ofr [ Me V-N <>0 (2S ,4R)-4-fluoro-N - [(S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(4-methyl-5-oxo-4,5-dihydro-l,2,4-oxadiazol-3-yl)acetyl]pyrrolidine-2-carboxamide 403 Me^Me rp^-F HN> (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] - l- {2-[4-(trifluoromethyl)- 1H-1,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide 404 Me^Me \h / ^N 11 N^Me (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] - l- {2-[(2-methylpyrimidin-4-yl)amino] acetyl }pyrrolidine-2-carboxamide 405 Me^Me Me^NH O^N,Me Me (2S,4R)-l-[(2S)-2- [(dimethylcarbamoyl)amino]propan oyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 406 Me Me ofr Me" NH O^N_Me Me (2S,4R)-l-[(2R)-2- [(dimethylcarbamoyl)amino]propan oyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 407 Q>P s    0=^ ^ / ~z / z IL (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1-[2-(1,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 408 Q>P os ® x= / ZI o \ / s     0=^ / z IL (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(5-methyl-l,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 409 Me^Me .a V-o Me (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(4-methyl-l,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 410 "Tl o / =°     3 [— Z Z Oiz / =,   o -f dd- (2S,4R)-l-{2-[(3,3- difluoroazetidine-1 -carbonyl)amino] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 411 o pz^ °1* ° / =\ • / d^ (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(5-methyl-2-oxo-2,3-dihydro-l,3,4-oxadiazol-3-yl)acetyl]pyrrolidine-2-carboxamide 412 Q>P IL (2S ,4R)-1 - {2-[4-(azetidin-1 -yl)-2H-1,2,3 -triazol-2-yl] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 413 nb-P IL (2S,4R)-l-{2-[4-(3,3-difluoroazetidin-1 -yl)-2H-1,2,3-triazol-2-yl] acetyl} -4-fluoro-N -[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 414 T1 f /  ,Zz / =°     a X / / '   O xz / ==,   ® (2S ,4R)-1 - {2- [4-(diethylamino)-2H-1,2,3 -triazol-2-yl] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 415 Me Me oU «n'n (lS,2S,5R)-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl]-3-[2-(lH-1,2,3-triazol-5-yl)acetyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide 416 / z £ (2S,5S)-N-[(S)-[6-fluoro-5- (propan-2-yl)pyridin-2-yl] (phenyl)methyl] - 5 -methyl-1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 417 JrF o ■ocro (25,4R)-1-(2-( 1H-benzo[ / / ]imidazol- l-yl)acetyl)- / V-((5)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl)-4-fluoropyrrolidine-2-carboxamide 418 cP ► - A Ny"e 0 (2S ,4R)-1 -acetyl-N- [(S )-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 419 .ijr’ Vn H O Me ff 0 (2S,5S)-l-acetyl-N-[(S)-(4- cyclopropyl-3-fluorophenyl)(phenyl)methyl] -5-methylpyrrolidine-2-carboxamide 420 .5-1 A J H O Me (lS,3S,5S)-2-acetyl-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -2-azabicyclo[3.1.0]hexane-3-carboxamide 421 o=( bz    o (2S)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -1-(2-acetamidoacetyl)pyrrolidine-2-carboxamide 422 OPF ' 4J (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [3 -(1,3 -oxazol-2-yl)propanoyl]pyrrolidine-2-carboxamide 423 A F\J O^Lo (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(3 -oxomorpholin-4-yl)acetyl]pyrrolidine-2-carboxamide 424 c^b-P ro zx o r p IL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro- l-[2-(2-oxo-1,3-oxazolidin-3-yl)acetyl]pyrrolidine-2-carboxamide 425 .J' oP Me (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(3 -methyl-2-oxoimidazolidin-1 -yl)acetyl]pyrrolidine-2-carboxamide 426 v d (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(1,3,4-oxadiazol-2-yl)acetyl]pyrrolidine-2-carboxamide 427 .0" n f^f (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -1 -{2-[5-(difluoromethyl)-1,3,4-oxadiazol-2-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 428 .a' \==N Fn F F (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1- {2-[5-(trifluoromethyl)-1,3,4-oxadiazol-2- yl] acetyl }pyrrolidine-2-carboxamide 429 .a' •■(I X=N (2S ,4R)-1 - [2-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)acetyl] -N- [(S )-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 430 0^F hn'nN (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3,4-tetrazol-5-yl)acetyl]pyrrolidine-2-carboxamide 431 .4’ Sm-n N N (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3,4-tetrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 432 0&F F '6 V" L ,N Me^N (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-1H-1,2,3,4-tetrazol- l-yl)acetyl]pyrrolidine-2-carboxamide 433 .4' '■<6^0 ^n-n m N Me (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-2H-1,2,3,4-tetrazol-2-yl)acetyl]pyrrolidine-2-carboxamide 434 A yO \=N hn^n Me (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-l-[2-(5-methyl-4H-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide 435 o >r F<^rc (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 H-pyrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 436 c4> P Cl IL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 H-pyrazol-5-yl)acetyl]pyrrolidine-2-carboxamide 437 o H (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 H-pyrazol-4-yl)acetyl]pyrrolidine-2-carboxamide 438 ll (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1,2-oxazol-3 -yl)acetyl]pyrrolidine-2-carboxamide 439 <2 0 (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 440 Z— / z- / ~^ >o \\ o IZ / =. " d '^ (1S ,2S ,5R)-N- [(S )-(4-cyclopropyl-3 -fluorophenyl) (phenyl) methyl] - 3 -[2-(lH-l,2,3 -triazol- 5 -yl) acetyl] - 3 -azabicyclo[3.1.0]hexane-2-carboxamide 441 A \h fl-Me Me (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -1 -{2-[(dimethylcarbamoyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 442 v-<4. (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl]pyrrolidine-2-carboxamide 443 -aVo <1' (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(quinolin-5-yl)acetyl]pyrrolidine-2-carboxamide 444 .O' r Me Me^N (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -1-[2-(3,5-dimethyl-1 H-pyrazol-4-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 445 T1 u_ 2-[(2S,4R)-2-{[(S)-(4-cyclopropyl-3- fluorophenyl)(phenyl)methyl]carba moyl} -4-fluoropyrrolidin-1 -yl] -2-oxoethyl 4-methylpiperazine-l-carboxylate 446 .5" 'G I ' F V-N^L.f F 2-[(2S,4R)-2-{[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carba moyl} -4-fluoropyrrolidin-1 - yl] - 2 -oxoethyl 4-(2,2,2-trifluoroethyl)piperazine-1 -carboxylate 447 2-[(2S,4R)-2-{[(S)-(4-cyclopropyl-3- fluorophenyl)(phenyl)methyl]carba moyl} -4-fluoropyrrolidin-1 - yl] - 2 -oxoethyl 4-(cyclopropylmethyl)piperazine-1 -carboxylate 448 P d^ o 3 • 2-[(2S,4R)-2-{[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carba moyl} -4-fluoropyrrolidin-1 - yl] - 2 -oxoethyl 4-(2-methoxyethyl)piperazine-1 -carboxylate 449 A Vn h I J r' °^nA i 0 Me (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(3 -methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl]pyrrolidine-2-carboxamide 450 .i' ^n'n 0 (2S,4R)-l-[2-(lH-l,2,3-benzotriazol-1 -yl)acetyl] -N- [(S )-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 451 o D ll 2-[(2S,4R)-2-{[(S)-(4-cyclopropyl-3- fluorophenyl)(phenyl)methyl]carba moyl} -4-fluoropyrrolidin-1 -yl] -2-oxoethyl azetidine-1-carboxylate 452 o d' 3¼ N-{2-[(2S,4R)-2-{[(S)-(4- cyclopropyl-3-fluorophenyl)(phenyl)methyl]carba moyl} -4-fluoropyrrolidin-1 - yl] - 2 -oxoethyl} morpholine-4 -carboxamide 453 V IL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 -oxo-2,3 -dihydro-1H-isoindol-2-yl)acetyl]pyrrolidine-2-carboxamide 454 " b^,9x IL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(2-oxo-2,3 -dihydro-1H-indol- l-yl)acetyl]pyrrolidine-2-carboxamide 455 P * 71° UP IL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(1 -methyl-2-oxo-2,3-dihydro- lH-indol-3-yl)acetyl]pyrrolidine-2-carboxamide 456 A U (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(2-oxo-2,3 -dihydro-1H-1,3 -benzodiazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 457 A VN  O I N-Me 6 (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-l-[2-(3-methyl-2-oxo-2,3-dihydro-1H-1,3 -benzodiazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 458 ►b P IL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 H-indazol-3 -yl)acetyl]pyrrolidine-2-carboxamide 459 b>p x, IL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 -methyl-1 H-indazol-3-yl)acetyl]pyrrolidine-2-carboxamide 460 IL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 H-indol-2-yl)acetyl]pyrrolidine-2-carboxamide 461 A ’Wo Mey I Xz Me 0 tert-butyl 2-{2-[(2S,4R)-2-{ [(S)-(4-cyclopropyl-3- fluorophenyl)(phenyl)methyl]carba moyl} -4-fluoropyrrolidin-1 -yl] -2-oxoethyl} -1 H-indole-1 -carboxylate 462 c <Me V-N r Vv (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 -methyl-1 H-indol-2-yl)acetyl]pyrrolidine-2-carboxamide 463 6-f o >r -Wo J^N-Me o (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 -methyl-1 H-indol-3 -yl)acetyl]pyrrolidine-2-carboxamide 464 .6" 8 Me 8 (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(2-methyl-1H-1,3 -benzodiazol-1-yl)acetyl]pyrrolidine-2-carboxamide 465 Jr' o >r -XsX o^Xnh (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(2-oxopiperazin-1 -yl)acetyl]pyrrolidine-2-carboxamide 466 J-' o Wo O^^N^JyF F (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-l-{2-[2-oxo-4-(2,2,2-trifluoroethyl)piperazin-1 -yl] acetyl }pyrrolidine-2-carboxamide 467 p.. IL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(2-oxo-2,3 -dihydro-1H-indol-3-yl)acetyl]pyrrolidine-2-carboxamide 468 .J" Me (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(4-methyl-1 H-imidazol-l-yl)acetyl]pyrrolidine-2-carboxamide 469 .O' -c&'O \h r^N ^n-n Me (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -1 -{2- [(1 -ethyl-1H-1,2,3 -triazol-4-yl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 470 0&F NH (T^n n-n J (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -1 -{2-[(2-ethyl-2H-l,2,3-triazol-4-yl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 471 0 >< 'nh (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - {2- [(pyrazin-2-yl)amino] acetyl }pyrrolidine-2-carboxamide 472 \h / N JI MS (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - {2- [(2-methylpyrimidin-4-yl)amino] acetyl }pyrrolidine-2-carboxamide 473 c^b-P s / ZI? z ,z- O= /    _ / Z-< 'Z y^z       z o o IL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -1 -{2- [(1 -ethyl-1H-1,2,3 -triazol-4-yl)(methyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 474 .O' F o VMe Pn n-n ''—Me (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -1 -{2-[(2-ethyl-2H-l,2,3-triazol-4-yl)(methyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 475 b> p J ^= / zz Q V IL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - {2-[methyl(pyrazin-2-yl)amino] acetyl }pyrrolidine-2-carboxamide 476 .J" VMe Sa ” Me (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - {2-[methyl(2-methylpyrimidin-4-yl)amino] acetyl }pyrrolidine-2-carboxamide 477 fr ysN Me (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro- l-[2-(2-methylquinolin-5-yl)acetyl]pyrrolidine-2-carboxamide 478 y o Q J. N N^ / (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-l-(2-{[l,2,4]triazolo[l,5-a]pyridin-6-yl}acetyl)pyrrolidine-2-carboxamide 479 .6’ r / 'i u H C 1 En M (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 -(2- {imidazo[ 1,2-a]pyridin-3 -yl} acetyl)pyrrolidine-2-carboxamide 480 3f (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro- l-[2-(2-methylquinolin-6-yl)acetyl]pyrrolidine-2-carboxamide 481 oy 1« N N (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(4H-1,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide 482 o Vn H IJ Nx HM 0 (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 -(2- {3-oxo-2H,3H-[l,2,4]triazolo[4,3-a]pyridin-8-yl} acetyl)pyrrolidine-2-carboxamide 483 -0¾ >A NY Me'N (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -1 -{2-[4-(dimethylamino)-2H-1,2,3-triazol-2-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 484 .i’ Vn V Mo-N'Me Me (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -1 -{2- [4-(dimethylamino)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 485 ’■<0V o N ™Z Me 0-(- Me Me tert-butyl N-[(5-{2-[(2S,4R)-2- {[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carba moyl} -4-fluoropyrrolidin-1 - yl] - 2 -oxoethyl} -1,3,4-oxadiazol-2-yl)methyl]carbamate 486 • o 01 d q - N-{2-[(2S,4R)-2-{[(S)-(4- cyclopropyl-3-fluorophenyl)(phenyl)methyl]carba moyl} -4-fluoropyrrolidin-1 - yl] - 2 -oxoethyl} -4-methylpiperazine-1 - carboxamide 487 2,0 f IL N-{2-[(2S,4R)-2-{[(S)-(4- cyclopropyl-3-fluorophenyl)(phenyl)methyl]carba moyl} -4-fluoropyrrolidin-1 -yl] -2-oxoethyl )-4-(2,2,2-trifluoroethyl)piperazine-1 -carboxamide 488 PF o NH OMe N-{2-[(2S,4R)-2-{[(S)-(4- cyclopropyl-3-fluorophenyl)(phenyl)methyl]carba moyl} -4-fluoropyrrolidin-1 - yl] - 2 -oxoethyl )-4-(2-methoxyethyl)piperazine-1 -carboxamide 489 .2’ \-0 II \_____. N N nh2 (2S ,4R)-1 - {2- [5-(aminomethyl)-1,3,4-oxadiazol-2-yl] acetyl} -N-[(S )-(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 490 Jr f 'O 'nh "2 N-{2-[(2S,4R)-2-{[(S)-(4- cyclopropyl-3-fluorophenyl)(phenyl)methyl]carba moyl} -4-fluoropyrrolidin-1 -yl] -2- oxoethyl}-4-(cyclopropylmethyl)piperazine-1 - carboxamide 491 >Hty P = V ^=7 ZZO \=z O=^   - / y- z LL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(5-oxo-4,5-dihydro-1H-l,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide 492 P A PT iL (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(5-oxo-4,5-dihydro-l,2,4-oxadiazol-3-yl)acetyl]pyrrolidine-2-carboxamide 493 .1?' -oVo N^NH hK 0 (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [3 -(5-oxo-4,5-dihydro-1H-l,2,4-triazol-3-yl)propanoyl]pyrrolidine-2-carboxamide 494 r Me V-N (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-l-[2-(4-methyl-5-oxo-4,5-dihydro-l,2,4-oxadiazol-3-yl)acetyl]pyrrolidine-2-carboxamide 495 .6- ^NH O^N-n LJ^f F (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -1 -{2-[(3,3-difluoroazetidine-1-carbonyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 496 -aim ^NH O^N-l F F (2S,4R)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-l-(2-{[3-(trifluoromethyl) azetidine-1 -carbonyl] amino} acetyl)pyrrolidine-2-carboxamide 497 (2S4 / <)-H2-(lH-l,2,3-triazol-5-yl)acetyl)-A / -((5) or (R)-(5-cyclopropylpyridin-2-yl)(phenyl)methyl)-4-fluoropyrrolidine-2-carboxamide 498 Tl O=' Vy (25,4^)-l-(2-(lH-l,2,3-triazol-5-yl)acetyl)-A / -((7?) or (5)-(5-cyclopropylpyridin-2-yl)(phenyl)methyl)-4-fluoropyrrolidine-2-carboxamide 499 V iL (2S,4R)-l-acetyl-N-[(S) or (R)-(5-cyclopropylpyridin-2-yl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 500 v< V iL (2S,4R)-l-acetyl-N-[(R) or (5)-(5-cyclopropylpyridin-2-yl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide (second eluting isomer) 501 . p =• °P >-z     o LL (25,4R)-A / -((5)-(5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl)(phenyl)methyl)-l-(2-(3-ethyl-5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1 (2 / 7)-yl) acetyl) -4 -fluoropyrrolidine-2-carboxamide 502 - r\ . “x / x-kv / X oK ° u_ (2S,4R)-N-[(S)-[5-(3,3- difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-l-[2-(5-methyl-2-oxo-2,3-dihydro-1,3,4-oxadiazol-3 - yl)acetyl]pyrrolidine-2-carboxamide 503 71 0 r” (2S ,4R)-1 - {2- [(azetidine-1 -carbonyl)amino] acetyl }-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 504 3X^3'’' / z u. (2S ,4R)-1 - [2-( 1H-1,3 -benzodiazol-l-yl)acetyl]-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 505 “x / yXV / / / vv / ZIo o=( X- / z / H u. (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-l-[2-(l,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 506 u.   O . HF t / P # '^■'X “- V \= / ZXo ' ZX oX >2    ° ■L (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-l-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 - yl)acetyl]pyrrolidine-2-carboxamide 507 F F oQ f' cr^^o XNH O^N,Me Me (2S,4R)-N-[(S)-[5-(3,3- difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] - l-{2- [(dimethylcarbamoyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 508 F F □ S' h%-n (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-l-[2-(lH-1,2,S-triazol-S-y^acety^pyrrolidine^-carboxamide 509 °K K- / z lL (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-1,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 510 F F □ S’ hn-nN (2S,4R)-N-[(S)-[5-(3,3- difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - {2- [4-(trifluoromethyl)- lH-l,2,3-triazol-5-yl] acetyl }pyrrolidine-2-carboxamide 511 F F oU V-o ■Q Me (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - [2-(4-methyl-1,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 512 J- NH o^n-, ‘A-r F (2S,4R)-l-{2-[(3,3-difluoroazetidine-1 -carbonyl)amino] acetyl }-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 513 f f oQ Fi yO ^n-n F L N 'Y^'N F (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -1 - {2- [5 - (difluoromethyl) -1H-1,2,3,4-tetrazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 514 Tl O / ^ / Z\ °IZ ° / =\ z\ o       / =\ H \ (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -l-[2-(2,4-dioxo-l, 2,3,4-tetrahydropyrimidin-1 -yl)acetyl] -4-fluoropyrrolidine-2-carboxamide 515 R F □ Q °^n4 < 0 Me (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -l-[2-(3-ethyl-2,4-dioxo-l,2,3,4-tetrahydropyrimidin-1 -yl)acetyl] -4-fluoropyrrolidine-2-carboxamide 516 ^o-&P o=Z V / 7 / z iL (2S,4R)-N-[(S)-[5-(3,3- difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - [2-(6-oxo-1,6- dihydropyridin-3-yl)acetyl]pyrrolidine-2-carboxamide 517 E F H (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - [2-(2-oxo-1,2-dihydropyridin-3- yl)acetyl]pyrrolidine-2-carboxamide 518 F 1= 0 1 r N"^_Me o^nA-< ° Me (2S,4R)-N-[(R)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -l-[2-(3-ethyl-5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 519 ■n / =© Z^Z \ O“   / =\     H ■ O      ,=(       v vy m (2S,4R)-N-[(S)-[5-(3,3- difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -1- [2-( 1 -ethyl-6-oxo-1,6-dihydropyridin-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 520 u. z\ “■     ^= / ZIO \ zx °=( iL (2S,4R)-N-[(R)-[5-(3,3- difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - [2-(6-oxo-1,6-dihydropyridin-3- yl)acetyl]pyrrolidine-2-carboxamide Fx F (2S,4R)-N-[(R)-[5-(3,3- fl -Pf difluorocyclobutyl)-6- [1 o x -n fluoropyridin-2-yl] (phenyl)methyl] - 521 “^SyZ--- 4-fluoro-1 - [2-(2-oxo-1,2- F"Z V-N H VsO T J dihydropyridin-3-yl)acetyl]pyrrolidine-2- O^N' H ) carboxamide Fx F (2S,4R)-N-[(S)-[5-(3,3- fl P,F difluorocyclobutyl)-6- H 0 X fluoropyridin-2-yl] (phenyl)methyl] - 522 --------- 4-fluoro-1 - [2-(5-methyl-6-oxo-1,6- F» H \^O u dihydropyridin-3-yl)acetyl]pyrrolidine-2- \^Me carboxamide H Fx F -L^f (2S,4R)-N-[(S)-[5-(3,3- [1 0 difluorocyclobutyl)-6- 523 "v— fluoropyridin-2-yl] (phenyl)methyl] - F« H LJ l-[2-(l-ethyl-5-methyl-6-oxo-l,6- dihydropyridin-3-yl)acetyl]-4- p ^Me fluoropyrrolidine-2-carboxamide " ° Me Fx f| F -L / F (2S,4R)-N-[(S)-[5-(3,3- [1 0 X <*N difluorocyclobutyl)-6- 524 F> z^Y^N' H ysO fluoropyridin-2-yl] (phenyl)methyl] -1 - [2-(6-ethoxy-5-methylpyridin-3 - iy. Me yl)acetyl]-4-fluoropyrrolidine-2- P carboxamide N5 O < Me 525 1' f.. Z^r Vn h IJ \^O rX-Me J < Me (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -1 - [2-( 1 -ethyl-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 526 ■n O ,-S\ 7=° A ° iz / =\ / \ "" dZ (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -1 - [2-( 1 -ethyl-2-oxo-1,2-dihydropyridin-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 527 F F □ S’ z Me (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -l-[2-(4-ethyl-5-oxo-4,5-dihydropyrazin-2-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 528 E F oM ■ <r x^o CF3 (2S,4R)-N-[(S)-[5-(3,3- difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - {2- [4-(trifluoromethyl)-1,3 -oxazol-2-yl] acetyl Jpyrrolidine-2-carboxamide 529 F F □ U FXa' H (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - [2-(3 -oxo-3,4-dihydropyrazin-2- yl)acetyl]pyrrolidine-2-carboxamide 530 F F Qo H 0 (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -4-fluoro-l-[2-(5-oxo-4,5-dihydropyrazin-2- yl)acetyl]pyrrolidine-2-carboxamide 531 'xj-- /             / ®Sl   • u / xZ \ /  '      z \ S -=7 ZIO A z-z °=( \-z     o 1L (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl] -l-[2-(4-ethyl-3-oxo-3,4-dihydropyrazin-2-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 532 F. F rs \^N HN^\ f"M U N r NH O=< N— / (2S,4R)-A / -((S)-(5-(3,3-difluorocyclobutyl)pyridin-2-yl)(phenyl)methyl)-1 -((dimethylcarbamoyl)glycyl)-4-fluoropyrrolidine-2-carboxamide 533 •^P □ “■             ZlQ T Z-1 o=( \-z     O iL (2S ,4R)-1 - {2- [(azetidine-1 -carbonyl)amino] acetyl} -N-[(S)- [5(3,3 -difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 534 ■7K' (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 535 F F oQ F<xyo XN^^,Me °^N-X H 0 (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl]pyrrolidine-2-carboxamide 536 .     p i x-Q X °K X- / z / z iL (2S,4R)-N-[(S)-[5-(3,3- difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-l,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 537 F F oO f-py 6N (2S ,4R)-1 - [2-( 1H-1,3 -benzodiazol-l-yl)acetyl]-N-[(S)-[5-(3,3-difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 538 V   ^=7  ZlQ  x Z—1 Y-z     o u_ (2S,4R)-l-{2-[(3,3- difluoroazetidine-1 -carbonyl)amino] acetyl} -N-[(S)- [5(3,3 -difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 539 1 Xo F 5 (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - [2-(1,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 540 ■n 2*- / z=Z^ )=° —4 A °IZ / =\ / k -n ■ d°a- (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - [2-(4-methyl-1,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 541 ■«n P ‘ \_ /        Zx O ° iL (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-2-oxo-2,3-dihydro-1,3,4-oxadiazol-3-yl)acetyl]pyrrolidine-2-carboxamide 542 ■n 2*-( z-Z^ >o z.X      / =\ . s^. (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - {2-[4-(trifluoromethyl)- 1H-1,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide 543 F F oQ V-o cf3 (2S,4R)-N-[(S)-[5-(3,3-difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl] -4-fluoro-1 - {2-[4-(trifluoromethyl)-1,3-oxazol-2-yl] acetyl }pyrrolidine-2-carboxamide 544 E F U 0 NH O^M No (25,47?)-1 -((azetidine-1 -carbonyl)glycyl)-A / -((5)-(4-(3,3-difluorocyclobutyl)-3-fluorophenyl)(phenyl)methyl)-4-fluoropyrrolidine-2-carboxamide 545 E F U 0 U NH O^M No (25,47?)-1 -((azetidine-1 -carbonyl)glycyl)-A / -((7?)-(4-(3,3-difluorocyclobutyl)-3-fluorophenyl)(phenyl)methyl)-4-fluoropyrrolidine-2-carboxamide 546 V \= / Zlo   ? °=( K / ~? / z iL (2S,4R)-N-[(S)-[4-(3,3- difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 547 FF ( J o ^y N^O \h O^N,Me Me (2S,4R)-N-[(S)-[4-(3,3- difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl] -1 - {2-[(dimethylcarbamoyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 548 F F Js^F ( J 0 NH O^N-Me Me (2S,4R)-N-[(R)-[4-(3,3-difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl] -1 -{2-[(dimethylcarbamoyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 549 / z il. (2S ,4R)-1 - [2-( 1H-1,3 -benzodiazol-l-yl)acetyl]-N-[(S)-[4-(3,3-difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 550 F F ( J 0 y^ Fi c / 'n^O r 0 N^Me (2S,4R)-N-[(S)-[4-(3,3-difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-1,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 551 F F A^f ( J o ^y ^sO N^_Me °^nX H 0 (2S,4R)-N-[(S)-[4-(3,3-difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 - yl)acetyl]pyrrolidine-2-carboxamide 552 / vv / ZIo K- / z iL (2S,4R)-N-[(S)-[4-(3,3-difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl] -4-fluoro-1 - [2-( 1,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 553 “yyyA... / £z V \= / ZIO X 'F °=( K / * / z iL (2S,4R)-N-[(S)-[4-(3,3- difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl] -4-fluoro-1 - {2-[4-(trifluoromethyl)- lH-l,2,3-triazol-5- yl] acetyl }pyrrolidine-2-carboxamide 554 F F ( J 0 V-o V Me (2S,4R)-N-[(S)-[4-(3,3-difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl] -4-fluoro-l-[2-(4-methyl-l,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 555 F F ( J 0 V-o V CF3 (2S,4R)-N-[(S)-[4-(3,3-difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl] -4-fluoro-1 - {2-[4-(trifluoromethyl)-l,3-oxazol-2-yl] acetyl Jpyrrolidine-2-carboxamide 556 -k-F CT o °^nA H ° (2S,4R)-4-fluoro-A / -((S)-(3-fluoro-4-(1-methylcyclopropyl)phenyl)(phenyl) methyl)- l-(2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1 (2 / / )-yl)acetyl)pyrrolidine-2-carboxamide 557 n 0 10 r AA H U (2S,4 / ?)-4-fluoro-7V-(( / ?)-(3-fluoro-4-(1-methylcyclopropyl)phenyl)(phenyl) methyl)-l-(2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1 (2 / / )-yl)acetyl)pyrrolidine-2-carboxamide 558 z— / Z-Z^ >=O z' \\   ° iz / = (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl]-l-[2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 559 o hnXN (2S ,4R)-4-fluoro-N - [(R)- [3 -fluoro-4-(1-methylcyclopropyl)phenyl](pyridin -3-yl)methyl]-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 560 ■n fl dO 2-[(2S,4R)-4-fluoro-2-{ [(S)-[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl) methyl] carbamoyl Jpyrrolidin-1 -yl] -2-oxoethyl azetidine-1 -carboxylate 561 iL (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 - [2-( 1 -methyl-1 H-indol-2-yl)acetyl]pyrrolidine-2-carboxamide 562 )-z     o lL (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 - [2-(2-oxopiperazin-1 -yl)acetyl]pyrrolidine-2-carboxamide 563 &y..p * o=\ V / \=^ / z 1L (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 - [2-( 1 -methyl-1 H-indol-3-yl)acetyl]pyrrolidine-2-carboxamide 564 >n N-Me 6 (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 - [2-( 1 -methyl-1H-indazol-3-yl)acetyl]pyrrolidine-2-carboxamide 565 Y-Me 'nh N-{2-[(2S,4R)-4-fluoro-2-{[(S)-[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl) methyl] carbamoyl }pyrrolidin-1 -yl] -2-oxoethyl]morpholine-4-carboxamide 566 Y-Me aF o - cd [ Me d (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 - [2-(2-methyl-1H-1,3 -benzodiazol-1-yl)acetyl]pyrrolidine-2-carboxamide 567 IL. (2S,4R)-1-[(2R) or (2S)-2-(lH-l,3-benzodiazol-1 -yl)propanoyl] -4-fluoro-N-[(S)-[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl) methyl]pyrrolidine-2-carboxamide 568 / 21¾ z-O o=\ V- / / H u. (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl]-l-[2-(3-methyl-2-oxo-2,3-dihydro-1H-1,3 -benzodiazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 569 Y-Me a 0 °^nA /    0 Me (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 - [2-(3 -methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl]pyrrolidine-2-carboxamide 570 Ymb r nh 0 (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 - [2-(2-oxo-2,3 -dihydro-1H-1,3 -benzodiazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 571 Y-Me & o F^ro \^N n NH 0 (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 - [2-( 1 H-indazol-3 -yl)acetyl]pyrrolidine-2-carboxamide 572 y-Me aF o O^^NH (2S ,4R)-1 - [2-(2,5-dioxopiperazin-1 -yl)acetyl] -4-fluoro-N- [(S)- [3 -fluoro-4-(l-methylcyclopropyl)phenyl](phenyl) methyl]pyrrolidine-2-carboxamide 573 IL (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 - [2-( 1 -oxo-2,3 -dihydro-lH-isoindol-2-yl)acetyl]pyrrolidine-2-carboxamide 574 r u Me *N^ d (2S,4R)-1-[(2S) or 2R)-2-(lH-l,3-benzodiazol-1 -yl)propanoyl] -4-fluoro-N-[(S)-[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl) methyl]pyrrolidine-2-carboxamide 575 ^ro 6 (2S,4R)-l-[2-(lH-l,2,3-benzotriazol-1 -yl)acetyl] -4-fluoro-N-[(S)-[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl) methyl]pyrrolidine-2-carboxamide 576 il (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 - [2-(2-oxo-2,3 -dihydro-IH-indol-1 -yl)acetyl]pyrrolidine-2-carboxamide 577 Tl z-7 XA /   Ao I (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 -[2-( 1 -methyl-2-oxo-2,3-dihydro- lH-indol-3-yl)acetyl]pyrrolidine-2-carboxamide 578 HyP a ° iL 2,2,2-trifluoroethyl 4-{2-[(2S,4R)-4-fluoro-2-{ [(S)-[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl) methyl] carbamoyl Jpyrrolidin-1 -yl] -2-oxoethyl} - 3-oxopiperazine-1 -carboxylate 579 2 0 --0-0. u. 2-[(2S,4R)-4-fluoro-2-{ [(S)-[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl) methyl]carbamoyl }pyrrolidin-1 -yl] -2-oxoethyl 4-(2-methoxyethyl)piperazine-1 -carboxylate 580 Tl O     Z-< d Olz\ / =W1 CO                   ' f (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 - {2- [2-oxo-4-(2,2,2-trifluoroethyl)piperazin-1 -yl] acetyl }pyrrolidine-2-carboxamide 581 s O o=\ AA—\=J / z iL (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1-methylcyclopropyl)phenyl](phenyl) methyl] -1 - [2-(2-oxo-2,3 -dihydro-lH-indol-3-yl)acetyl]pyrrolidine-2-carboxamide 582 V-Me -aw N-^ N N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1- methylcyclopropyl)phenyl](phenyl) methyl] -1 - [2-(4H-1,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide 583 Y-Me Me 2-[(2S,4R)-4-fluoro-2-{ [(S)-[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl) methyl] carbamoyl Jpyrrolidin-1 -yl] -2-oxoethyl 4-methylpiperazine-1-carboxylate 584 o o i£ 2-[(2S,4R)-4-fluoro-2-{ [(S)-[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl) methyl]carbamoyl }pyrrolidin-1 -yl] -2-oxoethyl 4-(cyclopropylmethyl)piperazine-1 -carboxylate 585 "H -n 2-[(2S,4R)-4-fluoro-2-{ [(S)-[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl) methyl]carbamoyl }pyrrolidin-1 -yl] -2-oxoethyl 4-(2,2,2-trifluoroethyl)piperazine-1 -carboxylate 586 .2xf •tfro 6 (25,47?)-1 -((7?) or (5)-2-(177-benzo [d] imidazol-1 -yl)propanoyl)-4-fluoro-A / -((5)-(6-fluoro-5-(l-methylcyclopropyl)pyridin-2-yl)(phenyl)methyl)pyrrolidine-2-carboxamide 587 \=<   \   O       ,---\    A ■ (IS AR)-1-((5) or (R)-2-(lH-benzo [d] imidazol-1 -yl)propanoyl)-4-fluoro-A / -((5)-(6-fluoro-5-(l-methylcyclopropyl)pyridin-2-yl)(phenyl)methyl)pyrrolidine-2-carboxamide 588 -= o VJO) o=\ K- / \=^ / z lL (2S ,4R)-4-fluoro-N - [(S)- [6-fluoro-5-(1 -methylcycloprop yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-( 1H-indazol-3-yl)acetyl]pyrrolidine-2-carboxamide 589 Y-'nh N-{2-[(2S,4R)-4-fluoro-2-{[(S)-[6-fluoro-5-(l-methylcyclopropyl)pyridin-2-yl] (phenyl)methyl] carbamoyl }pyrr olidin-l-yl]-2-oxoethyl} morpholine-4 -carboxamide 590 Y-Me •? "' CA x) C 6"" (2S ,4R)-4-fluoro-N-[(R)- [6-fluoro-5-(1 -methylcycloprop yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-( 1H-indazol-3-yl)acetyl]pyrrolidine-2-carboxamide 591 Y-Me .a ""QYYQ \^O [ Me X^N (2S ,4R)-4-fluoro-N - [(S)- [6-fluoro-5-(1 -methylcycloprop yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-( 1 -methyl-lH-indol-2-yl)acetyl]pyrrolidine-2-carboxamide 592 0 VN N-Me o (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(1 -methylcycloprop yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-( 1 -methyl-lH-indol-3-yl)acetyl]pyrrolidine-2-carboxamide 593 / 1¾ 2-0 O=<   _z \=G / H u. (2S ,4R)-4-fluoro-N - [(S)- [6-fluoro-5-(1 -methylcycloprop yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(2-methyl-1H-1,3 -benzodiazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 594 U21?! 2-0 °G / H iL (2S,4R)-l-[2-(lH-l,2,3-benzotriazol-1 -yl)acetyl] -4-fluoro-N-[(S)-[6-fluoro-5-(l-methylcyclopropyl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 595 cQ>P O=( / H lL (2S ,4R)-1 - [2-( 1H-1,3 -benzodiazol-l-yl)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(l-methylcyclopropyl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 596 r 0 VN. r N-Me a (2S ,4R)-4-fluoro-N - [(S)- [6-fluoro-5-(1 -methylcycloprop yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-( 1 -methyl-lH-indazol-3-yl)acetyl]pyrrolidine-2-carboxamide 597 Y-Me Vn ” 4,. (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(1 -methylcycloprop yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-( 1 -methyl-2-oxo-2,3 -dihydro-1 H-indol-3 -yl)acetyl]pyrrolidine-2-carboxamide 598 u. (2S ,4R)-4-fluoro-N - [(S)- [6-fluoro-5-(1 -methylcycloprop yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-( 1 H-indol-2-yl)acetyl]pyrrolidine-2-carboxamide 599 Y- ""ClYY^ r 0 I NH d (2S ,4R)-4-fluoro-N - [(S)- [6-fluoro-5-(1 -methylcycloprop yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(2-oxo-2,3 -dihydro-1H-1,3 -benzodiazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 600 Y Vn h O /    0 1 NMe 6 (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(1 -methylcycloprop yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(3 -methyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)acetyl]pyrrolidine-2-carboxamide 601 tib-Pvp IL. tert-butyl 2-{2-[(2S,4R)-4-fluoro-2-{[(S)-[6-fluoro-5-(l-methylcyclopropyl)pyridin-2-yl] (phenyl)methyl] carbamoyl }pyrr olidin-1 -yl] -2-oxoethyl} -1H-indole-1 -carboxylate 602 0M o> f^f (2S,47?)-l-(2-(5-(difluoromethyl)-l,3,4-oxadiazol-2-yl)acetyl)-4-fluoro-A / -((S)-(5-isopropyl-4-methylpyridin-2-yl)(phenyl)methyl)pyrrolidine-2-carboxamide 603 Im ° v F CNA MJ V"’ 0 (2S,4R)-l-acetyl-N-[(S) or (R)-(5-cyclobutylpyridin-2-yl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 604 / "A ® \ / » / = / “o tt \z E °=( / z 1L (2S,4R)-4-fluoro-N-[(S) or (R)-[4-methyl-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1-[2-(1 H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 605 z o ® )= / =o Vz / z lL (2S,4R)-4-fluoro-N-[(S) or (R)-[4-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(1 H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 606 Tl H 2- / ¾  )=° )-¾ 2 A o xz / ^ / o "H / =H^ Vz (2S,4R)-N-[(S) or (R)-[4- (difluoromethyl)-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 607 s ® \ \ / 1 / z lL (2S,4R)-4-fluoro-N-[(S) or (R)-[6-methyl-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(1 H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 608 Me Me FaC-^X FC^ U hn^N (2S,4R)-4-fluoro-N-[(S) or (R)-phenyl[5-(propan-2-yl)-4-(trifluoromethyl)pyridin-2-yl] methyl] -1 - [2-(1H-1,2,3 - triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 609 T1 4~z^°IZ< / =\ ® / S    3 ® \ /       (B (2S ,4R)-1 - {2- [5-(difluoromethyl)-1,3,4-oxadiazol-2-yl] acetyl} -4-fluoro-N-[(S) or (R)-[6-methyl-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 610 <V- / V2 /     z. V    = O C? °K / z 1L (2S,4R)-N-[(S) or (R)-(5-cyclobutylpyridin-2-yl)(phenyl)methyl] -4-fluoro-1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 611 £   O £^r       z. ®       2XO 1 ? s / z lL (2S,4R)-N-[(S) or (R)-(5-tert-butylpyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 612 o = P P ) \ <-z>-e        zzo V '? s       K^~= / z IL (2S,4R)-4-fluoro-N-[(S) or (R)-[6-methoxy-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(1 H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 613 Sr o Yr nh2 hn7 / (2S4 / <)-H2-(lH-l,2,3-triazol-5-yl)acetyl)-A / -((7?)-(2-aminopyridin-3-yl)(3-fluoro-4-isopropylphenyl)methyl)-4-fluoropyrrolidine-2-carboxamide 614 Me^Me oO II : H F" < 7  H Y 'n \ N   M   IL* Me (2S,4R)-l-acetyl-4-fluoro-N-[(S)-[4-(propan-2-yl)phenyl](lH-pyrazol-5-yl)methyl]pyrrolidine-2-carboxamide 615 z u.     iz' 0 \ / \            0) X= / ZZ Q Z 5 (2S)-N-[(R) or (S)-(4-cyclopropyl-3 -fluorophenyl) (1 H-pyrazol-5-yl)methyl] -1-(2-acetamidoacetyl)pyrrolidine-2-carboxamide 616 IL • c5 z ■ .yj, IL (2S,4R)-4-fluoro-N-[(R) or (S)-[3-fluoro-4-(propan-2-yl)phenyl] (5 -fluoropyridin-2-yl)methyl] -1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 617 Me^Me F ( J 0 F"CA U y;O f       F hn^nN (2S,4R)-4-fluoro-N-[(R) or (S)-[3-fluoro-4-(propan-2-yl)phenyl] (5 -fluoropyridin-3-yl)methyl] -1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 618 T1 s<A° . O ZZ / =\  * * / \ ' • -z z (2S,4R)-N-[(S) or (R)-(2-aminopyridin-4-yl) [3 -fluoro-4-(propan-2-yl)phenyl] methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 619 ■p z'     O iz / =\  • "z / =Hr= /   \__     x (D w" - (2S,4R)-4-fluoro-N-[(R) or (S)-[3-fluoro-4-(propan-2-yl)phenyl] (3 -fluoropyridin-4-yl)methyl] -1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 620 Me^Me u 0 -Ofc M \^NH2 HN> (2S,4R)-N-[(R) or (S)-(6-aminopyridin-3 -yl) [3 -fluoro-4-(propan-2-yl)phenyl] methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 621 Me^Me 1.F ( J 0 ^^nA / N^NH2 F,,U mJ (2S,4R)-N-[(R) or (S)-(6-aminopyridin-2-yl) [3 -fluoro-4-(propan-2-yl)phenyl] methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 622 T1 O ^ / Z\ S            / = O     g ®^z z Oiz / =\  ® f ,fcfc^s / \ — ® V / i • '—Z io (2S,4R)-N-[(R) or (S)-(2-aminopyridin-3 -yl) [3 -methyl-4-(propan-2-yl)phenyl] methyl] -1 - {2-[(dimethylcarbamoyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 623 z u. iz' E )\   )== yyyy z, E / z ■L (2S,4R)-4-fluoro-N-[(R) or (S)-[3-fluoro-4-(propan-2-yl)phenyl] (1H-pyrazol-5-yl)methyl] -1 - [2-( 1H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 624 Me^Me ofc -ofci hn:> (2S,4R)-N-[(R) or (S)-(2-aminopyridin-3 -yl) [3 -methyl-4-(propan-2-yl)phenyl] methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 625 Me Me [ Me YAl Me^N Me (2S,4R)-N-[(R) or (S)-(2-aminopyridin-3 -yl) [3 -methyl-4-(propan-2-yl)phenyl] methyl] -4-fluoro-1 - [2-( 1,3,5-trimethyl-1H-pyrazol-4-yl)acetyl]pyrrolidine-2-carboxamide 626 Y-Me ( J 0     OMe UN (2S,4R)-4-fluoro-N-[(R) or (S)-[3-fluoro-4-(l-methylcyclopropyl)phenyl] (2-methoxypyridin-3-yl)methyl]-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 627 Y-Me F ( J 0      Me f-cA un HNC (2S,4R)-4-fluoro-N-[(R) or (S)-[3-fluoro-4-(l-methylcyclopropyl)phenyl] (2-methylpyridin-3-yl)methyl] -1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 628 IL    Z / J— )—\ y~\ 1 z £     o / z u. (2S,4R)-4-fluoro-N-[(R) or (S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] ({imidazo [ 1,5-a]pyridin-3 -yl} )methyl] - l-[2-(lH-l ,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 629 z.Y / = / ^ / =°    a z, z °IZ / =\  ? r\=(     s Vz^Z (2S,4R)-4-fluoro-N-[(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] ({imidazo [ 1,5-a]pyridin-1 -yl} )methyl] - l-[2-(lH-l ,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 630 71 zP z^ / C >0   3 Co O:czx / =\ 7 / =(2   | k zx    "n z (2S,4R)-4-fluoro-N-[(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (1 H-pyrazol-5-yl)methyl] -1 - [2-(1,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 631 Me^Me Vnh   n F ,N (2S,4R)-4-fluoro-N-[(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] ({imidazo [ 1,5 -a] pyridin-7 -yl} )methyl] - l-[2-(lH-l ,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 632 XM / o iy ■ IL (2S,4R)-4-fluoro-N-[(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (1 H-indazol-6-yl)methyl] -1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 633 MeMe AF o v IT 1.          H ' ■ Qi B iCC" r V-NH T ,N (2S,4R)-4-fluoro-N-[(R) or (S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (1 H-indazol-6-yl)methyl] -1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 634 Z iz' u. r\ 0   \      \   / yX v< o \= / ZI o V' IL (2S ,4R)-1 -acetyl-4-fluoro-N- [(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (1 H-indazol-6-yl)methyl]pyrrolidine-2-carboxamide 635 T1 "Ao 3 o IZ / =\  • S V? ’ (2S ,4R)-1 -acetyl-4-fluoro-N- [(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (1 -methyl-1H-indazol-6-yl)methyl]pyrrolidine-2-carboxamide 636 Me Me N         N F"\ M H I T 'N-Me y° Me (2S ,4R)-1 -acetyl-4-fluoro-N- [(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl](2-methyl-2H-indazol-6-yl)methyl]pyrrolidine-2-carboxamide 637 A XI* H f, Ca " iCCn y° Me (2S,4R)-l-acetyl-N-[(S) or (R)-(5-cyclopropyl-6-fluoropyridin-2-yl)( 1 H-indazol-6-yl)methyl] -4-fluoropyrrolidine-2-carboxamide 638 0 VN      0 V H hn7 / methyl (3-((5)-((25,47?)-1 -(2-( 1H-l,2,3-triazol-5-yl)acetyl)-4-fluoropyrrolidine-2-carboxamido)(6-fluoro-5-isopropylpyridin-2-yl)methyl)benzyl)carbamate 639 Me^-Me 0     OMe Vn H O yO Me (2S)-l-acetyl-N-[(R)-(2-methoxyphenyl) [4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 640 Me^Me 0      Me / y'n / vS Vn H O Me (2S)-l-acetyl-N-[(R)-(2- methylphenyl) [4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 641 Me., Me 0 Y Me / x n^y\ Vn H O Ny0 Me (2S)-l-acetyl-N-[(S) or (R)-(2-methylphenyl)[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 642 Me^Me o      nh2 ^NyMe 0 (2S,4R)-l-acetyl-N-[(R) or (S)-(2-aminophenyl)[4-(propan-2-yl)phenyl] methyl] -4-fluoropyrrolidine-2-carboxamide 643 °yZ U. O-^A \ / X              a> x= / ZI o Z 2 o=( V>Z~< O (2S)-N-[(R) or (S)-(4-cyclopropyl-3-fluorophenyl) (2-oxo-2,3-dihydro -1,3 -benzoxazol-7-yl)methyl] -1-(2-acetamidoacetyl)pyrrolidine-2-carboxamide 644 ®        “o ft F s / z (2S)-N-[(R)-(2-oxo-2,3-dihydro-1H-1,3 -benzodiazol-4-yl) [4-(propan-2-yl)phenyl] methyl] -1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 645 Me^Me 0" o HnZ (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (3-fluorophenyl)methyl] -1 - [2-( 1H-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 646 T1 Z y i T| (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl](4-fluorophenyl)methyl] -1 - [2-( 1H-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 647 Me^Me J^F o 0 Yn oh (2S ,4R)-4-fluoro-N - [(R)- [3 -fluoro-4-(propan-2-yl)phenyl] (3-fluorophenyl)methyl] -1 - [2-( 1H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 648 ( Y o o HNZ A Y A >nh ^rs U "Y (2S)-N-[(S)-(4-cyclopropyl-3-fluorophenyl)(2-oxo-2,3-dihydro-1H-1,3 -benzodiazol-4-yl)methyl] -l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 649 Me^Me z . Me (2S,4R)-N-[(R)-(3- acetamidophenyl)[4-(propan-2-yl)phenyl] methyl] -4-fluoro-1 - [2-( 1 -methyl- 1H-1,2,3-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide 650 - / 0     HN-X f,Ca B (2S,4R)-N-[(R) or (S)-(4-cyclopropyl-3 -fluorophenyl)( 1 -methyl-2-oxo-2,3-dihydro-lH-l,3-benzodiazol-4-yl)methyl]-4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 651 71 z- z °IZ / =\  ? s-O ’ ’ CD '----- (2S,4R)-4-fluoro-N-[(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (3 -methoxyphenyl)methyl] -1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 652 Me^Me F f J 0 Vn H V r \^NH ( / , n N (2S,4R)-N-[(S) or (R)-cyclopropyl[3-fluoro-4-(propan-2-yl)phenyl] methyl] -4-fluoro-1- [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 653 Me Me ( T 0    A fi.ZVX'n'A^x^ Vn h r F,n N (2S,4R)-N-[(lS)or(lR)-2- cyclopropyl-l-[3-fluoro-4-(propan-2-yl)phenyl] ethyl] -4-fluoro-1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 654 Me^Me °? Fi Z^r Me       OMe (2S ,4R)-1 -acetyl-4-fluoro-N- [(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (3-methoxyphenyl)methyl]pyrrolidine-2-carboxamide 655 q IZ > 0 1 (2S,4R)-N-[(S)-[3- (acetamidomethyl)phenyl] [6-fluoro-5-(propan-2-yl)pyridin-2-yl] methyl] -4-fluoro-1 - [2-(1 H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 656 zx zx । y. ^ <0 & *   0^ / z / ■L (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl](3- {[(methylcarbamoyl)amino]methyl }phenyl)methyl] -1 - [2-( 1H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 657 71 Yz^ >° °= / =\ . (2S,4R)-N-[(S) or (R)-(5-cyclopropyl-6-fluoropyridin-2-yl)(2-fluorophenyl)methyl] -1 - {2-[5-(difluoromethyl)-lH-l,2,3,4-tetrazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 658 u. z. J21 ? 1- / V ■ iL (2S,4R)-N-[(S) or (R)-(5-cyclopropyl-6-fluoropyridin-2-yl)(4-fluorophenyl)methyl] -1 - {2-[5-(difluoromethyl)-lH-l,2,3,4-tetrazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 659 T T 0 \Yn hn'n (25,4R)-1 -(((1H-1,2,3-triazol-5-yl)methyl)sulfonyl)-A / -((5)-(3,5-difluoro-4-isopropylphenyl)(phenyl)methyl)-4-fluoropyrrolidine-2-carboxamide 660 fx^-L Y J 0 p r* 0 (2S,4R)-l-acetyl-N-[(S) or (R)-(4-cyclobutyl-3-fluorophenyl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 661 u. YA 0   \      \   / » )= / ,zi 0 / z lL (2S,4R)-N-[(S) or (R)-[3,5-difluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -4-fluoro-1 - [2-( 1,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 662 Y Y 0 '"■qY in 00 (2S ,4R)-N- [(S)-(4-cyclopropyl-3,5 -difluorophenyl)(phenyl)methyl]-4-fluoro-1 - [2-( 1,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide Me Me 663 fl 0      Me r^N (2S ,4R)-4-fluoro-N- [(S)- [2-methyl-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(1,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 664 O '"■qY^'O hn0n (2S,4R)-N-[(S)-(3-chloro-4-cyclopropylphenyl)(phenyl)methyl] -4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 665 = r>— L -z °Y     z / z 1L (2S,4R)-N-[(S)-(4-cyclopropyl-3-methylphenyl)(phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 666 U. 0   \      \   / Z * 07-0- / / z u. (2S,4R)-N-[(R) or (S)-[3,5-difluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 667 U. 0   \      \   / z S 00000 / z u. (2S,4R)-N-[(S) or (R)-[3,5-difluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 668 u. ® \ \ / ,z / H u. (2S,4R)-N-[(S) or (R)-[3,5-difluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 669 Me^Me T T o x^O n-n N N (2S,4R)-N-[(S)-[3,5-difluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3,4-tetrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 670 Me Me Jx^Me ( Y o >r HN> (2S,4R)-4-fluoro-N-[(S)-[3-methyl-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 671 » v O z “        2*0 V E <K / z u. (2S,4R)-N-[(R)-[3-chloro-4- (propan-2-yl)phenyl] (phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 672 Me^Me Jx / CI ( J 0 UM .N HN'N (2S,4R)-N-[(S)-[3-chloro-4- (propan-2-yl)phenyl] (phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 673 ■n z— / z- / ~Y >=° H' 3 OlZ / =-   . 'z Xvyv (2S,4R)-N-[(R) or (S)-(4-cyclobutyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 674 V         V'Z °Y K / x / z iL (2S,4R)-N-[(S) or (R)-(4-cyclobutyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 675 J^F ( Y 0 f"(YT H Yn 0H M ¥n -N N (2S,4R)-N-[(S) or (R)-(4-cyclobutyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3,4-tetrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 676 .. ^Me Me y F ( J 0 hn^nN (2S,4R)-N-[(R) or (S)-{4-[(2R) or (2S)-butan-2-yl]-3-fluorophenyl} (phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 677 .. x\>“e Me y ( J 0 Fll< / ^Y^N T^Yl Yn " *U hn! / (2S,4R)-N-[(S) or (R)-{4-[(2R) or (2S)-butan-2-yl]-3-fluorophenyl} (phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 678 Mev___,Me Me^Y-F Y Y 0 F"C^hV) Ny.O HN? (2S,4R)-4-fluoro-N-[(R) or (S)-[3-fluoro-5-methyl-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 679 t A  YA ® \     \ / z ®       2=0 V'Z iL (2S,4R)-N-[(S)-[3- (difluoromethyl)-4-(propan-2-yl)phenyl] (phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 680 Mev___.Me Me^Y-F Y Y 0 F"C^hV) Ny;O hnYn (2S,4R)-4-fluoro-N-[(S) or (R)-[3-fluoro-5-methyl-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 681 \^Me Y^P ( Y o ’■'U ; hnY-n (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(1- methylcyclobutyl)phenyl](phenyl) methyl]-l-[2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 682 Y J 0 F"(I H Yn £ N'\, ny Me (2S,4R)-N-[(S) or (R)-(4- cyclopropyl-3 -fluoro-5-methylphenyl)(phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-2H-1,2,3,4-tetrazol-2-yl)acetyl]pyrrolidine-2-carboxamide 683 "z / =Hr^ / \     V ® vJ * (2S,4R)-4-fluoro-N-[(S) or (R)-phenyl[4-(propan-2-yl)-3-(trifluoromethyl)phenyl] methyl] -1 -[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 684 p-Me ( J 0 f" / Yt H |YY Vn oh m HN> (2S ,4R)-4-fluoro-N - [(R)- [3 -fluoro-4-(1-methylcyclobutyl)phenyl](phenyl) methyl]-l-[2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 685 .. Me.. Me^EMe aF 0 (2S,4R)-N-[(S)-(4-tert-butyl-3-fluorophenyl)(phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 686 0 TN HN'N f-Zt' Vry0 M hn7 / (2S,4R)-l-(2-(lH-l,2,3-triazol-5-yl) acetyl) -N- ((5)-(3-(177-pyrazol- 5 -yl)phenyl)(6-fluoro-5-isopropylpyridin-2-yl)methyl)-4-fluoropyrrolidine-2-carboxamide 687 1.F O y'1^ HN'N hn7 / (25,4R)-l-(2-(lH-l,2,3-triazol-5-yl) acetyl) - N- ((R)-(3 - (1 TZ-pyrazol-5 -yl)phenyl)(6-fluoro-5-isopropylpyridin-2-yl)methyl)-4-fluoropyrrolidine-2-carboxamide 688 z / \= / zi o ° \ Z~ / z (25,4R)-A / -((5) or (R)-(3-(4H-1,2,4-triazol-3 -yl)phenyl)(6-fluoro-5-isopropylpyridin-2-yl)methyl)-l-acetyl-4-fluoropyrrolidine-2-carboxamide 689 A^f u 0 Y    HN^ UI X N f"UhJJ N' (25,4R)-A / -((R) or (5)-(3-(477-1,2,4-triazol-3 -yl)phenyl)(6-fluoro-5-isopropylpyridin-2-yl)methyl)-l-acetyl-4-fluoropyrrolidine-2-carboxamide 690 Me^Me 4' lb x > f,,Ca            » Me (2S ,4R)-1 -acetyl-4-fluoro-N- [(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] [3-(1 H-pyrazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide 691 3 3 X ° IZ  r—o o ’ IZ. z (2S,4R)-l-(2-acetamidoacetyl)-4-fluoro-N-[(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl][3-(lH-pyrazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide 692 9 i 0  1 •     Ln U h L J r V-NH r ,n ^N (2S,4R)-4-fluoro-N-[(R) or (S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] [3-(1,3-oxazol-5-yl)phenyl] methyl] - l- [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 693 Me^^Me oM 9 i 0 1 ■     Ln F • • / jT N Vn h U y u V-NH r ,n ^N (2S,4R)-4-fluoro-N-[(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] [3-(1,3-oxazol-5-yl)phenyl] methyl] - l- [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 694 Me^Me oM  N 0 y    O-N p.^a'icA V-NH F / n ^n' (2S,4R)-4-fluoro-N-[(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] [3-(1,2-oxazol-5-yl)phenyl] methyl] - l- [2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 695 0 u.= Za O   \      \   / ®  \= / ZI o u. (2S ,4R)-1 -acetyl-4-fluoro-N- [(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] [3-(1 -methyl-1H-pyrazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide 696 Me ., Ms o LN HN-N X b _ X / Me f"Cj h iQj y° Me (2S ,4R)-1 -acetyl-4-fluoro-N- [(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] [3 -(3 -methyl-1H-pyrazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide 697 Me ., Me O V 'V AL-. A. / "Ms f,<j a iQj y° Me (2S,4R)-l-acetyl-N-[(S) or (R)-[3-(1,3 -dimethyl-1 H-pyrazol-5-yl)phenyl] [6-fluoro-5-(propan-2-yl)pyridin-2-yl]methyl]-4-fluoropyrrolidine-2-carboxamide 698 ’A . oxz / =\ • / =^2^-^S / \ — • vy ex (2S ,4R)-1 -acetyl-4-fluoro-N- [(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] [3-(1,2-oxazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide 699 A Z-Z u.    Za ®  \     \ / 5         ,ZI ° ■ / IL (2S ,4R)-1 -acetyl-4-fluoro-N- [(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] [3-(1 H-pyrazol-1 -yl)phenyl]methyl]pyrrolidine-2-carboxamide 700 Me_Me 0 Y II*   Ln f"Cj " Me (2S ,4R)-1 -acetyl-4-fluoro-N- [(S) or (R)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl][3-(l,3,4-oxadiazol-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 701 z \ '°    3 / —'     ° iz / =\ ® /          / =?       s /   \               (D (2S)-l-(oct-7-ynoyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 702 F            Me °XH° Me     X^ (2S ,4R)-4-fluoro-1-(1 -methyl-1H-indazole-5-carbonyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 703 MeO \   Me^Me o / oo F (2S,4R)-4-fluoro-l-[2-(4- methoxyphenyl)cyclopropanecarbo nyl] -N- [(S )-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 704 Me O Me T n ,NH F (2S,4R)-4-fluoro-l-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbonyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 705 Me Me Me       O HN^° F (2S,4R)-4-fluoro-l-[2-(2- methylpropoxy)pyridine-4-carbonyl]-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 707 0- / 5. . / 7~Z      O IZ    / =x   O ■9 (2S,4R)-4-fluoro-l-[4-(lH-imidazol-1 -yl)pyridine-2-carbonyl] -N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 708 HN U / VVl Me fl Me (2S,4R)-4-fluoro-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]-1-{[(pyridin-3-yl)c arb amoyl] carbonyl} pyrrolidine-2-carboxamide 709 k>P /    \___ /    '                      fl) ®  ^=7 ZX O      5 o=( kyV° 1L (2S ,4R)-4-fluoro-1 -(5-methoxy-1 -methyl- lH-pyrazole-3-carbonyl)-N-[(S)-phenyl[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide 710 Me^.Me „Q '<sX3 ( Me V-N N W'N Me (2S ,4R)-1 - [2-( 1,4-dimethyl-5-oxo-4,5-dihydro-lH-l,2,4-triazol-3-yl)acetyl] -4-fluoro-N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 711 ®         \ 7 „z d 4^=7    \jT O=z / z LL (2S ,4R)-1 - {2-[4-(azetidin-1 -yl)- 1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 712 Me Me .6 r N N ^-OMe "'N Me (2S,4R)-4-fluoro-l-[2-(5-methoxy-1-methyl- 1H-1,2,4-triazol-3-yl)acetyl] -N- [(S )-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 713 ® \ / yy y. /   z . \= / Zzo b D iL (2S ,4R)-1 - {2- [5-(diethylamino)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 714 Me^Me oC f- \—N H L J r m r~N'Z^ / F -1_J F (2S,4R)-l-{2-[5-(3,3-difluoroazetidin-1 -yl)- 1H-1,2,3-triazol-1 -yl] acetyl} -4-fluoro-N -[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 715 Me^Me ,6 Cj (2S ,4R)-1 - {2-[5-(azetidin-1 -yl)- 1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoro-N-[(S)-phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide 716 I|An 0 I c, Vn h O c 6" (2S ,4R)-1 - [2-( 1H-1,3 -benzodiazol-1 -yl)acetyl] -N- [(R)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 717 Mes M_ NMe nA An ?■ (2S,4R)-N-[(R)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [4-(dimethylamino)-2H-1,2,3-triazol-2-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 718 Fi, u H O N^o Z / Nx N^ HNA 0 (2S,4R)-N-[(R)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-(2-{3-oxo-2H,3H-[l,2,4]triazolo[4,3-a]pyridin-8-yl} acetyl)pyrrolidine-2-carboxamide 719 .J' *<6^0 ( M® V-N x?=0 (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(4-methyl-5-oxo-4,5-dihydro-l,2,4-oxadiazol-3-yl)acetyl]pyrrolidine-2-carboxamide 720 0^F "(A u r NH f N JI N^Me (2S,4R)-N-[(R)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - {2- [(2-methylpyrimidin-4-yl)amino] acetyl }pyrrolidine-2-carboxamide 721 T1 z— / )=° z' \\ O iz / =\ ■ d0-" (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 722 f, , / r Vn h IJ r Me X—N N ^=° ™'N Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-[2-(l,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 723 c^b-P ^=7 zio z_y o=^  —7 V- z LL (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - [2-( 1 H-pyrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 724 .1?-' (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - [2-(5 -methyl-1H-pyrazol-l-yl)acetyl]pyrrolidine-2-carboxamide 725 .a' -<pro F^^7 F (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [5 - (difluoromethyl) -1H-pyrazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 726 .&■ (2S ,4R)-1 - {2-[4-(azetidin-1 -yl)- 1H-1,2,3-triazol- 1-yl] acetyl} -N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 727 Jr H 0 (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-[2-(2,4-dioxo-l,2,3,4-tetrahydropyrimidin-1 -yl)acetyl] -4-fluoropyrrolidine-2-carboxamide 728 Ub-P ^=7 ZTO z_V o=Z — / V- 2 iL (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - {2- [4-(trifluoromethyl)-IH-pyrazol-1 -yl] acetyl} pyrrol i di nc-2-carboxamide 729 .O’ -Giro F (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [3 - (difluoromethyl) -1H-pyrazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 730 .a ’■aYo (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - {2- [3 -(trifluoromethyl)-IH-pyrazol-1 - yl] acetyl ]pyrrolidine-2-carboxamide 731 •G ^Ns^0 H (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - [2-(2-oxo-1,2-dihydropyridin-3-yl)acetyl]pyrrolidine-2-carboxamide 732 >Yj-P p° Gr u. (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - [2-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)acetyl]pyrrolidine-2-carboxamide 733 . J-' f, ,,       n "^zZZ U h IJ r N^^Me o^NX < ° Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-[2-(3-ethyl-5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 734 H 0 (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - [2-(6-oxo-1,6-dihydropyridin-3-yl)acetyl]pyrrolidine-2-carboxamide 735 O^nA < 0 Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-[2-(3-ethyl-2,4-dioxo-l,2,3,4-tetrahydropyrimidin-1 -yl)acetyl] -4-fluoropyrrolidine-2-carboxamide 736 .i" ; 0 Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-[2-( 1 -ethyl-6-oxo-1,6-dihydropyridin-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 737 ^P u_ (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - [2-(6-ethoxy-5-methylpyridin-3 -yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 738 V-o cf3 (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - {2- [4-(trifluoromethyl)-1,3 -oxazol-2-yl] acetyl } pyrro 1 idi nc-2-carboxamide 739 i' " ° Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-[2-(l-ethyl-5-methyl-6-oxo-l,6-dihydropyridin-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 740 .i" 7^V-Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - [2-( 1 -ethyl-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 741 .jf -ayo (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - [2-( 1 -ethyl-2-oxo-1,2-dihydropyridin-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 742 .t9 T N 0 Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-[2-(4-ethyl-5-oxo-4,5-dihydropyrazin-2-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 743 r N fl ^~OMe 'N Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - [2-(5 -methoxy-1 -methyl- 1H-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide 744 o G “J KzZ / =° °'Z Z Oiz   / =, d o-d (2S,4R)-1-(2- {[benzyl(trifluoromethyl)carbamoyl ] amino} acetyl)-N - [(S )-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 745 - -A ■ dd* (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - {2- [5-(trifluoromethyl)-lH-l,2,3-triazol-l-yl] acetyl }pyrrolidine-2-carboxamide 746 ^■P ^=7 ZI o \  21 "V li. (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(5-oxo-4,5-dihydropyrazin-2-yl)acetyl]pyrrolidine-2-carboxamide 747 A F"GrAAn r Vn f^ / n F (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [5-(difluoromethyl)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 748 .Ji’ r r n Me^N Me^ (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-{2-[5-(diethylamino)-lH-1,2,3-triazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 749 F" Z^r N <4." U f X ,N-Me F (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [3 - (difluoromethyl) -1 -methyl-1 H-pyrazol-4-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 750 .O' -aVo 1 V— Me F^>^= / F (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [5 - (difluoromethyl) - 3 -methyl-1 H-pyrazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 751 A fyQn F Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [5 - (difluoromethyl) -1 -methyl-1 H-pyrazol-4-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 752 \= / zio °=( Y \ / z S ■L (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [3 - (difluoromethyl) - 5 -methyl-1 H-pyrazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 753 \= / Zlo A 2^ / u_ (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-[2-(4-ethyl-3-oxo-3,4-dihydropyrazin-2-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 754 .a' s ( Me \-N F.PN F (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [4-(difluoromethyl)-1 -methyl-1 H-pyrazol-5-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 755 A Vn h I J r \-N X -N f3c^n (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - {2- [5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1 -yl] acetyl }pyrrolidine-2-carboxamide 756 A' V-NH F X > F (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-{2-[4-(difluoromethyl)-lH-1,2,3-triazol-5-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 757 A -aVo X^N F F (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [4-(difluoromethyl)-1 -methyl-1 H-pyrazol-3 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 758 r r n rN F (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [5-(3,3 -difluoroazetidin-1 -yl)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 759 "T1 (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - {2- [3 -(difluoromethyl)-4H-1,2,4-triazol-4-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide 760 r FsC'^ (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1 - {2- [5-(trifluoromethyl)-IH-pyrazol-1 - yl] acetyl }pyrrolidine-2-carboxamide 761 A r0 N^Me Me (2S,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-1 - [2-(4,5-dimethyl-1,3 -oxazol-2-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide 762 i' C / N " (2S ,4R)-1 - {2-[5-(azetidin-1 -yl)- 1H-1,2,3-triazol- 1-yl] acetyl] -N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 763 HO o Y r F X -N F (2S,3R,4R)-N-[(S)-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -1 - {2- [5-(difluoromethyl)- 1H-1,2,3,4-tetrazol-1 -yl] acetyl} -4-fluoro-3 -hydroxypyrrolidine-2-carboxamide 764 (X HO ?   = N V" F X ,N 'Y^N F (2S ,3 S ,4S )-N- [(S )-(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -1 - {2- [5-(difluoromethyl)- 1H-1,2,3,4-tetrazol-1 -yl] acetyl} -4-fluoro-3 -hydroxypyrrolidine-2-carboxamide 765 Me Me J^F 0 f.. \—N H L J VsO Jr 0 J^H^Me h2n^0 h (2S,4R)-l-[(2S)-3-carbamoyl-2-acetamidopropanoyl]-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl](phenyl)methyl]pyrrolidi ne-2-carboxamide 766 Me Me F 0 '<ro Me^^N k N N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl] -1 - [(2R) or (2S )-2-( 1H-1,2,3,4-tetrazol-1 -yl)propanoyl]pyrrolidine-2-carboxamide 767 Me Me X^F 0 Me^N-N L N N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl] -1 - [(2S) or (2R)-2-( 1H-1,2,3,4-tetrazol-1 -yl)propanoyl]pyrrolidine-2-carboxamide 768 A ®  X= / ZIO \ # o = LL (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl] -1 - [(2R) or (2S)-2-(lH-imidazol-l-yl)propanoyl]pyrrolidine-2-carboxamide 769 pi u. (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl] -1 - [(2R) or (2S)-2-(lH-l,2,3-triazol-5-yl)propanoyl]pyrrolidine-2-carboxamide 770 Me^Me 0 -X-x Me-P^ (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl] -1 - [(2S) or (2R)-2-(lH-l,2,3-triazol-5-yl)propanoyl]pyrrolidine-2-carboxamide 771 Me x. Me 0 'px Me [^N (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl] -1 - [(2S) or (2R)-2-(lH-imidazol-l-yl)propanoyl]pyrrolidine-2-carboxamide 772 Me Me 0 Sf° r° (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl] -1 - [(1H- 1,2,3-triazol-5- yl)methanesulfonyl]pyrrolidine-2-carboxamide 773 "71 ■ d'^ (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl] -1 - [(2R) or (2S)-2-hydroxy-2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 774 Me Me F 0 (2S,4R)-4-fluoro-N-[(S)-[3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl] -1 - [(2S) or (2R)-2-hydroxy-2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 775 Me Me / L / f 0 ’'<dX> X-NH Me (2S ,4R)-1 - {2-[4-(dimethylamino)-lH-l,2,3-triazol-5-yl]acetyl}-4-fluoro-N-[(S)-[3-fluoro-4-(propan- 2- yl)phenyl](phenyl)methyl]pyrrolidi ne-2-carboxamide 776 Me Me X iQ HN> (2S,4R)-4-fluoro-N-[(R*)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(1 H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 777 Me Me "<JX> / o Me (2S ,4R)-1 - [2-(3,5-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-l-yl)acetyl]-4-fluoro-N-[(R*)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 778 iz \ O iz ,=, n> 4 (2S,4R)-4-fluoro-N-[(R*)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(5-methyl-2,4-dioxo-l,2,3,4-tetrahydropyrimidin-1 -yl)acetyl]pyrrolidine-2-carboxamide 779 Me,, Me .6' - cd-'o Y Me N N n'N Me (2S ,4R)-1 - [2-( 1,4-dimethyl-5-oxo-4,5-dihydro-lH-l,2,4-triazol-3-yl)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 780 QyP LL (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] - l-(3-{3 -oxo-2H,3H-[l,2,4]triazolo[4,3-a]pyridin-2-yl}propanoyl)pyrrolidine-2-carboxamide 781 Me-.Me (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-( 1H-pyrazol-l-yl)acetyl]pyrrolidine-2-carboxamide 782 Me Me -<Xro Me^^7 (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(5-methyl-lH-pyrazol-l-yl)acetyl]pyrrolidine-2-carboxamide 783 Me^.Me F (2S ,4R)-1 - {2- [5-(difluoromethyl)-1 H-pyrazol-1 -yl] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2- yl] (phenyl)methyl]pyrrolidine-2-carboxamide 784 Me Me .a' y^y-Me nA H 0 (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(5-methyl-6-oxo-1,6-dihy drop yridin-3-yl)acetyl]pyrrolidine-2-carboxamide 785 MeMe .a' - <^ro NA H 0 (2S ,4R)-1 - [2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl] -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 786 Me Me .a' NA °^nA < 0 Me (2S ,4R)-1 - [2-(3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1 -yl)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 787 Me^-Me .a' -Aro Sa (2S ,4R)-1 - {2-[4-(azetidin-1 -yl)- 1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 788 Me^Me A -Aro Q cf3 (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] - l- {2-[4-(trifluoromethyl)- IH-pyrazol-1-yl] acetyl }pyrrolidine-2-carboxamide 789 ‘ bb P S    o=^  — / )-2 LL (2S ,4R)-1 - {2- [3 -(difluoromethyl)-1 H-pyrazol-1 -yl] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2- yl] (phenyl)methyl]pyrrolidine-2-carboxamide 790 Qy P ®  ^=7  2x0 S     o=^   — / )-2 LL (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] - l- {2-[3-(trifluoromethyl)-1 H-pyrazol-1-yl] acetyl }pyrrolidine-2-carboxamide 791 Me Me nA H 0 (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(6-oxo-1,6-dihydropyridin-3-yl)acetyl]pyrrolidine-2-carboxamide 792 Me^.Me A '"C / 'AO < 0 Me (2S ,4R)-1 - [2-( 1 -ethyl-6-oxo-1,6-dihydropyridin-3-yl)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2- yl] (phenyl)methyl]pyrrolidine-2-carboxamide Me^^Me 793 p 1L (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(2-oxo-1,2-dihydropyridin-3-yl)acetyl]pyrrolidine-2-carboxamide Me Me 794 .a' "pX> N^pMe °^nA < ° Me (2S ,4R)-1 - [2-(3 -ethyl-5-methyl- 2,4-dioxo-l,2,3,4-tetrahydropyrimidin-1 -yl)acetyl] -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide Me^Me 795 p 1 1L (2S ,4R)-1 - [2-( 1 -ethyl-2-oxo-1,2-dihydropyridin-3-yl)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2- yl] (phenyl)methyl]pyrrolidine-2-carboxamide Me Me 796 .a’ • C^TO yp_-Me < ° Me (2S ,4R)-1 - [2-( 1 -ethyl-5-methyl-6-oxo-1,6-dihydropyridin-3-yl)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 797 Me Me .a' ■ u < 0 Me (2S,4R)-l-[2-(4-ethyl-5-oxo-4,5-dihydropyrazin-2-yl)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 798 Me-, Me 0U y'^Me u Me (2S,4R)-l-[2-(6-ethoxy-5- methylpyridin-3-yl)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 799 Me -, Me .6’ "X'X V^X-Me JT Me (2S ,4R)-1 - [2-( 1 -ethyl-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 800 Me -, Me XX X^n M ^~OMe n'N Me (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1-[2-(5-methoxy-1 -methyl- 1H-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide 801 Me Me .a' F 5 cf3 (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] - l- {2-[4-(trifluoromethyl)-1,3-oxazol-2-yl] acetyl }pyrrolidine-2-carboxamide 802 Me^Me .a' -<Zro Q h 0 (2S ,4R)-4-fluoro-N - [ (S)- [6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl] -1 - [2-(5-oxo-4,5-dihydropyrazin-2-yl)acetyl]pyrrolidine-2-carboxamide 803 A ®  ^= / zio E     O=^   — / A 2 LL (2S ,4R)-1 - {2- [5-(difluoromethyl)-3 -methyl-1 H-pyrazol-1 -yl] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 804 Me Me A -a)™ Me^^7 F (2S ,4R)-1 - {2- [3 -(difluoromethyl)-5-methyl-1 H-pyrazol-1 -yl] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 805 Me Me On 0 " a^FO V" Me^N Me^ (2S ,4R)-1 - {2 - [5-(diethylamino)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2- yl] (phenyl)methyl]pyrrolidine-2-carboxamide 806 Me Me ^Me (2S ,4R)-1 - [2-(4-ethyl-3 -oxo-3,4-dihydropyrazin-2-yl)acetyl]-4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 807 Me Me .6' ■ Gdx> r~N F -Lj F (2S,4R)-l-{2-[5-(3,3-difluoroazetidin-1 -yl)- 1H-1,2,3-triazol-1 -yl] acetyl} -4-fluoro-N -[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 808 Me., Me oi Vn GN (2S ,4R)-1 - {2-[5-(azetidin-1 -yl)- 1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoro-N-[(S)-[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl]pyrrolidine-2-carboxamide 809 o = u. (2S,4R)-1-[(2S) or (2R)-2-(lH-l,3-benzodiazol-1 -yl)propanoyl] -N -[(S )-(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide 810 o 6 (2S,4R)-1-[(2R) or (2S)-2-(lH-l,3-benzodiazol-1 -yl)propanoyl] -N -[(S )-(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide

[0238] In some embodiments, provided herein is a compound of formula (I), or any variation or embodiment thereof, or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, the compound, or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, is selected from the group consisting of: l-cyclopropanecarbonyl-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-acetyl-4-hydroxy-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-acetyl-3-hydroxy-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-acetyl-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-acetyl-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; l-(3-carbamoyl-2-acetamidopropanoyl)-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; tert-butyl N- {2-oxo-2- [2-( {phenyl[4-(propan-2-yl)phenyl] methyl} carbamoyl)pyrrolidin-1 -yl] ethyl} carbamate; l-(2-hydroxyacetyl)-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(2-acetamidoacetyl)-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-acetyl-N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoropyrrolidine-2-carboxamide; l-(3-carbamoylpropanoyl)-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-acetyl-N-[(5-cyclopropylpyridin-2-yl)(phenyl)methyl]-4-fluoropyrrolidine-2-carboxamide; 2-acetyl-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-2-azabicyclo[3.1.0]hexane-3-carboxamide; 1 - {2 - [N-(carbamoylmethyl)acetamido] acetyl} -4-fluoro-N - {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-acetyl-5-methyl-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(l,3-oxazol-2-yl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-(4H-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-1 - {2- [(3 -methyloxetan-3 -yl)amino] acetyl} -N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-acetamido-5- [4-fluoro-2-( {phenyl[4-(propan-2-yl)phenyl] methyl} carbamoyl)pyrrolidin-1 -yl] -5-oxopentanoic acid; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}-l-[2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide; l-(3-acetamidopropanoyl)-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 -[2-(2-oxopyrrolidin-1 -yl)acetyl] -N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 -[2-( 1,3-oxazol-5-yl)acetyl] -N- {phenyl[4-(propan-2-yl)phenyl]methyl }pyrrolidine-2-carboxamide; l-(4-acetamidobutanoyl)-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 2-acetyl-N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-2-azabicyclo[3.1.0]hexane-3-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-l-(2-acetamidoacetyl)pyrrolidine-2-carboxamide; 3-acetyl-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-3-azabicyclo[3.1.0]hexane-2-carboxamide; 4-fluoro- l-[2-(2-oxo-l, 3-oxazolidin-3-yl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(oxetan-3-yl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 -[2-(3 -oxomorpholin-4-yl)acetyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-acetyl-N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-5-methylpyrrolidine-2-carboxamide; 4-fluoro-1 - [2-( 1 -methyl-1 H-pyrazol-5-yl)acetyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 H-pyrazol-1 - yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(3 -oxomorpholin-4- yl)acetyl]pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-[2-(5-methyl-4H-l,2,4-triazol-3- yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [3 -(1,3 -oxazol-2- yl)propanoyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3,4-tetrazol-1 - yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(2-oxo-1,3 -oxazolidin-3 - yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 H-pyrazol-5- yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3,4-tetrazol-5- yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1,2-oxazol-3 - yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-( IH-pyrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-( 1H-1,2,3-triazol-1 - yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-(2H-1,2,3,4-tetrazol-5-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-1 - [2-(1,3,4-oxadiazol-2-yl)acetyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 H-pyrazol-4-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-1 - {2-[( 1,3-oxazol-2-yl)amino] acetyl} -N- {phenyl[4-(propan-2- yl)phenyl]methyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(3 -methyl-2-oxoimidazolidin-1 -yl) acetyl] pyrrolidine-2 -carboxamide; 1 - [2-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)acetyl] -N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl]-4-fluoropyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-{2-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl] acetyl }pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -1 - {2- [5-(difluoromethyl)-1,3,4-oxadiazol-2-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl] methyl} -1 - [3 - (1H-1,2,4-triazol-1 -yl)propanoyl]pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(l-methyl-lH-pyrazol-4-yl)acetyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-( 1H-1,2,3,4-tetrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}-l-[2-(pyridazin-3-yloxy)acetyl]pyrrolidine-2-carboxamide; 4-fluoro- l-(l-methyl-5-oxopyrrolidine-2-carbonyl)-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(2-chloro-5-fluorophenyl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-[4-(pyridin-3-yl)butanoyl]pyrrolidine-2-carboxamide; 4-fluoro-1 -(3-oxo-octahydroindolizine-6-carbonyl)-N - {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-(2-oxopiperidine-4-carbonyl)-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(2-cyano-4-methoxyphenyl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-{3-oxo-2H,3H-[l,2,4]triazolo[4,3-a]pyridine-8-carbonyl}-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - [4-( 1 H-imidazol-1 -yl)butanoyl] -N- {phenyl [4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-[2-(pyrimidin-5-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro- l-(4-methylpyrimidine-5-carbonyl)-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(2-oxo-l, 2-dihydropyridin-l-yl)acetyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[3-(3,5-dimethyl-l,2-oxazol-4-yl)propanoyl]-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - [2-(3 -fluoro-4-methoxyphenyl)acetyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1-(1,3-oxazole-5-carbonyl)-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-[4-(pyridin-4-yl)butanoyl]pyrrolidine-2-carboxamide; 1 - [(dimethylcarbamoyl)carbonyl] -4-fluoro-N - {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-l-yl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 -[2-( IH-imidazol-1 -yl)acetyl] -N- {phenyl[4-(propan-2-yl)phenyl] methyl Jpyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-( lH-pyrazol-5-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-1 - [2-methyl-3 -(1H-1,2,4-triazol-1 -yl)propanoyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(5-fluoropyridin-2-yl)acetyl]-N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(5-methyl- lH-indol-3-yl)acetyl]-N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(4-acetamidophenyl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 -[2-( lH-imidazol-4-yl)acetyl] -N- {phenyl[4-(propan-2-yl)phenyl] methyl} pyrrol idi nc-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}-l-[3-(pyridin-3-yl)propanoyl]pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(4-methoxyphenyl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(l,5-dimethyl-lH-pyrazol-3-yl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[3-(2-methylpyridin-3-yl)propanoyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}-l-[2-(pyrimidin-2-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}-l-[3-(pyrazin-2-yl)propanoyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-(2H-1,2,3-triazol-2- yl)acetyl]pyrrolidine-2-carboxamide; l-[3-(2,6-dimethylpyridin-3-yl)propanoyl]-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 -[2-( 1H-1,2,3-benzotriazol-1 -yl)acetyl] -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl] methyl } -1 - [2-( 1 ,3,5-trimethyl-1 H-pyrazol-4-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-[2-(pyridin-3-yloxy)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-1 - [3 -(1 H-imidazol-5-yl)propanoyl] -N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - [3 -(5 -methyl-1,3,4-thiadiazol-2-yl)propanoyl] -N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - [3 -(3,5-dimethyl-1 H-pyrazol-1 -yl)propanoyl] -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 -(3 -cyanopropano yl)-4-fluoro-N - {phenyl[4-(propan-2-yl)phenyl] methyl} pyrrolidine-2-carboxamide; 1 - {2- [(dimethylcarbamoyl)amino] acetyl} -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(5-methyl-1,2,4-oxadiazol-3-yl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(l-methyl-lH-indol-2-yl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - [3 -(5 -methylpyridin-2-yl)propanoyl] -N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 -(2-ethyl-1,3 -oxazole-4-carbonyl)-4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(2-methyl- l,3-thiazol-4-yl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}-l-[2-(pyrazin-2-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro- l-[2-methyl-3-( lH-pyrazol-l-yl)propano yl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[3-(lH-indol-3-yl)propanoyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-methyl-3-(pyridin-4-yl)propanoyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(4-fluoro-lH-indol-l-yl)acetyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - {4-oxo-4H,5H,6H,7H,8H-pyrazolo[ 1,5-a] [ 1,4]diazepine-2-carbonyl} -N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-{2-[5-(propan-2-yl)-l,2,4-oxadiazol-3-yl] acetyl }pyrrolidine-2-carboxamide; 4-fluoro-l-(6-oxopiperidine-3-carbonyl)-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl] methyl} -1 - [2-(pyrrolidine-1 - sulfonyl)acetyl]pyrrolidine-2-carboxamide; 1 - [2-( 1,2-benzoxazol-3 -yl)acetyl] -4-fluoro-N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}-l-(2-{[ 1,2,4]triazolo[l, 5-a]pyridin-6- yl} acetyl)pyrrolidine-2-carboxamide; 1 -[2-( 1H-1,3-benzodiazol-1 -yl)acetyl] -4-fluoro-N - {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl] methyl } -1 - [2-( 1 H-pyrazol-1 - yl)propanoyl]pyrrolidine-2-carboxamide; 4-fluoro- l-[3-(3-methoxypyridin-2-yl)propanoyl]-N-{ phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - [2-( 1 H-imidazol-1 -yl)propanoyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(3,5-dimethyl-l,2-oxazol-4-yl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - [2-( 1 -methyl-1 H-pyrazol-3 -yl)acetyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-[3-(lH-1,2,3-triazol-l-yl)propanoyl]pyrrolidine-2-carboxamide; 4-fluoro-1 - [3 -(1 H-imidazol-2-yl)propanoyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 -[2-(2-methylphenoxy)acetyl] -N- {phcny I [ 4-(propan-2-y I Jphcny IJ methyl} pyrrol idi nc-2-carboxamide; 4-fluoro- l-[2-(3-methyl- l,2-oxazol-5-yl)acetyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-(3-methyloxetane-3-carbonyl)-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(4-chloro-lH-pyrazol-l-yl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1-(1 -ethyl-1 H-pyrazole-5 -carbonyl)-4-fluoro-N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-[2-(pyridin-2-yl)propanoyl]pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-[3-(pyrimidin-5-yl)propanoyl]pyrrolidine-2-carboxamide; 4-fluoro-1 -(3 -methoxy-1 -methyl-1 H-pyrazole-4-carbonyl)-N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - [2-(5-methyl-1,3,4-oxadiazol-2-yl)acetyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl] methyl }-l-[3-(l H-pyrazol-4- yl)propanoyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-( 1,3-thiazol-4-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-1 -[4-(2-methyl- IH-imidazol-1 -yl)butanoyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 -(2- {imidazo[ 1,2-a]pyridin-3 -yl} acetyl)-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-[3-(pyridin-2-yl)propanoyl]pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(3-methyl-l,2,4-oxadiazol-5-yl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - [2-(3,5-dimethyl-1 H-pyrazol-1 -yl)acetyl] -4-fluoro-N - {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[3-(6-methylpyridin-3-yl)propanoyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-(3-{ lH-pyrrolo[2,3-b]pyridin-3- yl}propanoyl)pyrrolidine-2-carboxamide; 4-fluoro-l-(2-oxo-l,3-oxazolidine-5-carbonyl)-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(4-methyl-lH-pyrazol-l-yl)acetyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[3-(l -methyl- lH-pyrazol-4-yl)propanoyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-( 1H-1,2,4-triazol-1 - yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}-l-[5-(pyridin-4-yl)-lH-pyrazole-3- carbonyl]pyrrolidine-2-carboxamide; 4-fluoro-l-[3-(2-methylpyridin-4-yl)propanoyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-(2-hydroxy-3-methylbutanoyl)-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-(3-{ lH-pyrrolo[2,3-b]pyridin-5-yl}propanoyl)pyrrolidine-2-carboxamide; 4-fluoro-1 - [4-oxo-4-(pyrrolidin-1 -yl)butanoyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}-l-[2-(quinolin-6-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-[2-(pyridin-4-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-(2,2,2- trifluoroacetamido)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl] methyl} -1 - [2-(pyridin-3 - yloxy)propanoyl]pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(lH-indol-3-yl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(2-cyclopropyl-2-oxoacetyl)-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - [2-(5 -fluoro-2-methoxyphenyl)acetyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(6-methoxypyridin-2-yl)acetyl]-N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(2-oxo-l, 2-dihydropyridin-l-yl)propanoyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}-l-[2-(pyridin-3-yl)acetyl]pyrrolidine-2-carboxamide; 1 - [2-(3,5-dimethyl-1 H-pyrazol-4-yl)acetyl] -4-fluoro-N - {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 -[2-(2,5-dioxoimidazolidin-1 -yl)acetyl] -4-fluoro-N - {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(2,5-dimethyl-l,3-thiazol-4-yl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-methyl-3-(pyridin-2-yl)propanoyl]-N-{ phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(2-oxo-l, 2-dihydropyrazin-l-yl)acetyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(N-methylacetamido)propanoyl]-N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-methyl-2-(pyridin-2-yl)propanoyl]-N-{ phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(2-oxopiperidin-l-yl)acetyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}-l-[2-(quinolin-5-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl] methyl} -1 - [3 - (1H-1,2,4-triazol-1 - yl)benzoyl]pyrrolidine-2-carboxamide; 4-fluoro-l-{[(2-methylpropyl)carbamoyl]carbonyl}-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-( 1H-1,2,3,4-tetrazol-1 -yl)propanoyl]pyrrolidine-2-carboxamide; 4-fluoro-1 -(2-oxo-1,2,3,4-tetrahydroquinoline-7-carbonyl)-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(2-methyl- l,3-thiazol-5-yl)acetyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[3-(6-oxo-l, 6-dihydropyridazin-3-yl)propanoyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(4-methyl- lH-pyrazol-l-yl)propano yl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}-l-[2-(pyridin-2-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-1 - [2-(3 -methyl-1 H-pyrazol-1 -yl)acetyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-(3-oxo-3,4-dihydro-2H-l, 4-benzoxazine-6-carbonyl)-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(2-acetamidopyridine-4-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-( lH-pyrazol-3-yl)acetyl]pyrrolidine-2-carboxamide; N-{[3-fluoro-4-(propan-2-yl)phenyl](phenyl)methyl}-3-[2-(lH-l,2,3-triazol-5-yl)acetyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-1H-1,2,3,4-tetrazol-1 -y 1) acetyl] pyrrolidine-2 -carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1,3,4-oxadiazol-2-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}-l-[2-(lH-l,2,3-tri azol-5-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2 - (1H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide; N-{[3-fluoro-4-(propan-2-yl)phenyl](phenyl)methyl]-2-[2-(lH-l,2,3-triazol-5-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carboxamide; N-{[3-fluoro-4-(propan-2-yl)phenyl](phenyl)methyl}-5-methyl-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3-fluoro-4-(propan-2-yl)phenyl](phenyl)methyl]-l-(2-hydroxy-2-methylpropanoyl)pyrrolidine-2-carboxamide; 4-fluoro-1 - [2-(5-methyl- 1H-1,2,3,4-tetrazol-1 -yl)acetyl] -N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl }-l-[2-(lH-l,2,3,4-tetrazol-5-yl)acetyl]pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-[2-(5-methyl-2H-l,2,3,4-tetrazol-2-yl) acetyl] pyrrolidine-2 -carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -3-[2-(lH-l ,2,3 -triazol-5-yl)acetyl] -3 -azabicyclo[3.1.0]hexane-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl }-l-[2-(lH-l ,2,3 -triazol-1 -yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl }-l-[2-(lH-l,2,3,4-tetrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-(4H-1,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(4-methyl-4H-l,2,4-triazol-3-yl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(l -methyl- 1H-1,2,3-triazol-5-yl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(l-methyl-1H-1,2,3-triazol-4-yl)acetyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 -[2-( 1,2-oxazol-4-yl)acetyl] -N- {phenyl[4-(propan-2-yl)phenyl]methyl }pyrrolidine-2-carboxamide; 4-fluoro-1 -[2-( 1,2-oxazol-3-yl)acetyl] -N- {phenyl[4-(propan-2-yl)phenyl]methyl }pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(3-methyl-1H-1,2,4-triazol-5-yl)acetyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl } -1 - [2-( 1 -methyl-1 H-pyrazol-5-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl } -1 - [2-( 1 -methyl-1 H-pyrazol-3 -yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl } -1 - [2-( 1 -methyl-1H-1,2,3 -triazol-5 -yl) acetyl] pyrrolidine-2 -carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(pyridin-2-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(5-methyl-1,3,4-oxadiazol-2-yl)acetyl] pyrrolidine-2 -carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(pyridin-3 -yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(pyrimidin-4-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(pyrimidin-5-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(pyrazin-2-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N-{[3-fluoro-4-(propan-2-yl)phenyl](phenyl)methyl}-l-[2-(4-methyl-2,5- dioxopiperazin- l-yl)acetyl]pyrrolidine-2-carboxamide; l-(2-cyanoacetyl)-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-(2-methanesulfonylacetyl)-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-( 1H-1,2,3-triazol-1 - yl)propanoyl]pyrrolidine-2-carboxamide; l-(4-acetylmorpholine-2-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(4-acetyl-3,4-dihydro-2H-l,4-benzoxazin-2-yl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(4-acetyl-2-oxopiperazin-l-yl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1-(1 -acetylpiperidine-4-carbonyl)-4-fluoro-N - {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(2,3-dihydroxypropanoyl)-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-{8-acetyl-8-azaspiro[4.5]decane-2-carbonyl}-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[3-(lH-imidazol-l-yl)-2-methylpropanoyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-{6-acetyl-6-azaspiro[2.5]octane-l-carbonyl}-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(l-acetyl-3-methylpyrrolidine-3-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - [2-(N-methylacetamido)acetyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - {2-acetyl-5-oxa-2,6-diazaspiro[3.4]oct-6-ene-7-carbonyl} -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[l-acetyl-2-(pyridin-3-yl)pyrrolidine-3-carbonyl]-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[5-(methoxymethyl)-l,2-oxazole-4-carbonyl]-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-{6-acetyl-5H,6H,7H,8H-pyrido[3,4-b]pyrazine-7-carbonyl}-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-(1H-1,2,4-triazol-1 - yl)propanoyl]pyrrolidine-2-carboxamide; l-{5-acetyl-5-azaspiro[2.4]heptane-l-carbonyl}-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - [3 -(1 -acetylpyrrolidin-2-yl)propanoyl] -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - {4- [(1 -acetylazetidin-3-yl)oxy]benzoyl} -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - [3 -methoxy-2-(N-methylacetamido )butanoyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(l-acetylpyrrolidin-2-yl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - {7-acetyl-1 -oxa-2,7-diazaspiro[4.4]non-2-ene-3 -carbonyl} -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - {5-acetyl-hexahydro-1 H-furo [3,4-c]pyrrole-3 a-carbonyl} -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(l-acetylpyrrolidine-3-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - [2-(3 -methyl-1 H-pyrazol-5-yl)acetyl] -N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-{5-acetyl-2-oxa-5-azabicyclo[2.2.1]heptane-l-carbonyl}-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(l-acetylpiperidin-4-yl)propanoyl]-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-methyl-2-(lH-l,2,4-triazol-5-yl)propanoyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-methyl-2-( 1,3,4-oxadiazol-2-yl)propanoyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(pyridin-4- yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 -(2- {imidazo [ 1,2-a]pyridin-3 - yl} acetyl)pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl } -1 - [2-( 1 H-imidazol-1 - yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl } -1 - [2-( 1 ,3,5-trimethyl-1 H-pyrazol-4-yl) acetyl] pyrrolidine-2 -carboxamide; 4-fluoro-N- {[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-( 1,2-oxazol-5-yl)acetyl]pyrrolidine-2-carboxamide; 1 - {2- [(dimethylcarbamoyl)amino] acetyl} -4-fluoro-N- {[3 -fluoro-4-(propan-2- yl)phenyl] (phenyl) methyl} pyrrolidine-2 -c arboxamide; N-{[3-fluoro-4-(propan-2-yl)phenyl](phenyl)methyl}-4-[2-(lH-l,2,3-triazol-5-yl)acetyl]-4-azaspiro[2.4]heptane-5-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl } -1 -(2- {[ 1 ,2,4] triazolo [1,5- a]pyridin-6-yl}acetyl)pyrrolidine-2-carboxamide; 4-fluoro-N- {[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(quinolin-6- yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl } -1 - [2-( 1 -methyl-1 H-pyrazol-4-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl} -1 - [2-(piperazin-1 -yl)acetyl]pyrrolidine-2-carboxamide; l-(l-acetyl-3-methylpiperidine-3-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(l-acetyl-4-methylazepane-4-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(l-acetylazepane-4-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1-(1 -acetylpiperidine-3 -carbonyl)-4-fluoro-N - {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(4-acetylmorpholine-3-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 -(2- {2-acetyl-2-azaspiro [3.4]octan-5-yl} acetyl)-4-fluoro-N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-{2-acetyl-2-azaspiro[4.4]nonane-6-carbonyl}-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - {2-acetyl-2-azabicyclo [2.2.2] octane-6-carbonyl} -4-fluoro-N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(l-acetylpiperidin-3-yl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(4-acetyl-l,4-oxazepane-2-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(l-acetyl-4-methylpiperidine-3-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(4-acetyl-2-methylmorpholine-3-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-{5-acetyl-hexahydro-2H-furo[2,3-c]pyrrole-3-carbonyl}-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - {3 -acetyl-3 -azabicyclo [3.1.0]hexane-1 -carbonyl} -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - {2-acetyl-octahydrocyclopenta[c]pyrrole-4-carbonyl} -4-fluoro-N - {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-{8-acetyl-8-azabicyclo[3.2.1]octane-3-carbonyl}-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1-(1 -acetyl-3 -methylazetidine-3 -carbonyl)-4-fluoro-N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-{5-acetyl-hexahydro-2H-furo[2,3-c]pyrrole-2-carbonyl}-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-{3-acetyl-3-azabicyclo[3.2.1]octane-8-carbonyl}-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(2-acetyl-octahydro-lH-isoindole-4-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - {7-acetyl-7-azabicyclo [2.2.1 ]heptane-2-carbonyl} -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-{2-acetyl-5-oxa-2-azaspiro[3.4]octane-7-carbonyl}-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 -[2-( 1 -acetyl-3-methylazetidin-3-yl)acetyl] -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-{2-acetyl-5-oxa-2-azaspiro[3.4]octane-6-carbonyl}-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(l-acetyl-2-methylpiperidine-3-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-{3-[N-(l-methyl-lH-pyrazol-3-yl)acetamido]propanoyl}-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1-(1 -acetyl-3 -fluoroazetidine-3 -carbonyl)-4-fluoro-N- {phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(l-acetyl-3-methoxyazetidin-3-yl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - {4-acetyl-hexahydro-2H-furo[3,2-b]pyrrole-6-carbonyl} -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(l-acetyl-4-ethylpyrrolidine-3-carbonyl)-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - {7-acetyl-1 -oxo-2,7-diazaspiro[4.4]nonane-4-carbonyl} -4-fluoro-N- {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl } -1 - [ 1 -(1,3,4-oxadiazol-2-yl)cyclopropanecarbonyl]pyrrolidine-2-carboxamide; 2-[4-fluoro-2-({[3-fluoro-4-(propan-2-yl)phenyl](phenyl)methyl}carbamoyl)pyrrolidin-l-yl]-2-oxoethyl N,N-dimethylcarbamate; 1 -[2-( 1H-1,3-benzodiazol-1 -yl)acetyl] -4-fluoro-N - {[3-fluoro-4-(propan-2-yl)phenyl] (phenyl) methyl} pyrrolidine-2 -c arboxamide; 1 - [2-( 1H-1,3 -benzodiazol-1 -yl)acetyl] -N- [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide; 2-[4-fluoro-2-({phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}carbamoyl)pyrrolidin-l-yl]-2-oxoethyl N,N-dimethylcarbamate; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl } -1 - [2-( 1 -methyl-1H-1,2,3 -triazol-4-yl) acetyl] pyrrolidine-2 -carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidine-2-carboxamide; 1 - {2- [(dimethylcarbamoyl)amino] acetyl} -4-fluoro-N- {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -1 - {2- [(dimethylcarbamoyl) amino] acetyl} -4-fluoropyrrolidine-2-carboxamide; 4-fluoro- l-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-l-yl)acetyl]-N-{phenyl[5- (propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}-l-[2-(quinolin-5-yl)acetyl]pyrrolidine-2-carboxamide; tert-butyl 4-({2-[4-fluoro-2-({ [3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl} carbamoyl)pyrrolidin-1 -yl] -2-oxoethyl} carbamoyl)piperazine-1 -carboxylate; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -1 - [2-(3,5-dimethyl-1 H-pyrazol-4-yl)acetyl] -4-fluoropyrrolidine-2-carboxamide; N- {2- [4-fluoro-2-( {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} carbamoyl)pyrrolidin-1 - y 1] -2-oxoethyl }piperazine-l-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(quinolin-5-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[5-(propan-2-yl)pyridin-2-yl] methyl }-l-[2-(lH-l,2,3,4-tetrazol-1 - yl)acetyl]pyrrolidine-2-carboxamide; l-[2-(4-acetylpiperazin-l-yl)acetyl]-4-fluoro-N-{phenyl[4-(propan-2- yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(5-methyl-2-oxo-2,3-dihydro-l,3,4-oxadiazol-3-yl)acetyl]-N-{phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-[2-(3,5-dimethyl-2,4-dioxo-l,2,3,4-tetrahydropyrimidin-l-yl)acetyl]-4-fluoro-N-{[3-fluoro-4-(propan-2-yl)phenyl](phenyl)methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide; 1 - {2- [(dimethylcarbamoyl)(methyl)amino] acetyl} -4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl) methyl} pyrrolidine-2 -c arboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 -(2-oxo-1,3 -oxazolidine-5- carbonyl)pyrrolidine-2-carboxamide; 2-[4-fluoro-2-({[3-fluoro-4-(propan-2-yl)phenyl](phenyl)methyl}carbamoyl)pyrrolidin-l-yl]-2-oxoethyl piperazine-1-carboxylate; l-[2-(3,5-dimethyl-lH-pyrazol-4-yl)acetyl]-4-fluoro-N-{phenyl[5-(propan-2-yl)pyridin-2- yl]methyl}pyrrolidine-2-carboxamide; 1-tert-butyl 4-{2-[4-fluoro-2-({ [3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl} carbamoyl)pyrrolidin-1 -yl] -2-oxoethyl} piperazine-1,4-dicarboxylate; 1 - {2- [5-(difluoromethyl)-1,3,4-oxadiazol-2-yl] acetyl} -4-fluoro-N - {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 1 -[2-( 1H-1,3-benzodiazol-1 -yl)acetyl] -4-fluoro-N - {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 1 - {2- [5-(difluoromethyl)-1,3,4-oxadiazol-2-yl] acetyl} -4-fluoro-N - {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl) methyl} pyrrolidine-2 -c arboxamide; tert-butyl N-({5-[2-(2-{[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carbamoyl}-4- fluoropyrrolidin-l-yl)-2-oxoethyl]-l,3,4-oxadiazol-2-yl}methyl)carbamate; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(pyridazin-4-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}-l-{2-[5-(trifluoromethyl)-2H-1,2,3,4-tetrazol-2-yl]acetyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -5-methyl-1 - [2-( 1H-1,2,3 -triazol-5 -yl) acetyl] pyrrolidine-2 -carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(pyridazin-3 - yl)acetyl]pyrrolidine-2-carboxamide; N - [(5-cyclopropylpyridin-2-yl)(phenyl)methyl] -4-fluoro-1-[2-(1 H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(2-oxopiperazin-1 - yl)acetyl]pyrrolidine-2-carboxamide; N-[2-(2-{[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carbamoyl}-4-fluoropyrrolidin-l-yl)-2-oxoethyl]-4-methylpiperazine-l-carboxamide; N-[2-(2-{[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carbamoyl}-4-fluoropyrrolidin-l-yl)-2-oxoethyl] -4-(2,2,2-trifluoroethyl)piperazine-l -carboxamide; N-{2-[4-fluoro-2-({phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}carbamoyl)pyrrolidin-l-yl]-2-oxoethyl}-4-(2,2,2-trifluoroethyl)piperazine-l-carboxamide; N-[2-(2-{[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carbamoyl]-4-fluoropyrrolidin-l-yl)-2-oxoethyl]-4-(2-methoxyethyl)piperazine-l-carboxamide; 1 - {2- [5-(aminomethyl)-1,3,4-oxadiazol-2-yl] acetyl} -N- [(4-cyclopropyl-3 - fluorophenyl)(phenyl)methyl]-4-fluoropyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(5-methyl-1H-1,2,3 -triazol-1 -yl) acetyl] pyrrolidine-2 -carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(4-methyl-1H-1,2,3 -triazol-1 -yl) acetyl] pyrrolidine-2 -carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - {2- [4-(piperazin- 1 -yl)-2H-l,2,3-triazol-2-yl]acetyl}pyrrolidine-2-carboxamide; N-[2-(2-{[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carbamoyl]-4-fluoropyrrolidin-l-yl)-2-oxoethyl]-4-(cyclopropylmethyl)piperazine-l-carboxamide; 4-(cyclopropylmethyl)-N-{2-[4-fluoro-2-({phenyl[5-(propan-2-yl)pyridin-2- yl]methyl }carbamoyl)pyrrolidin-1-yl]-2-oxoethyl }piperazine-1-carboxamide; N-{2-[4-fluoro-2-({phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}carbamoyl)pyrrolidin-l-yl]-2-oxoethyl} -4-methylpiperazine-1 -carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(4-methyl-1H-1,2,3 -triazol-5 -yl) acetyl] pyrrolidine-2 -carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - {2- [4-(trifluoromethyl)-1H- l,2,3-triazol-l-yl]acetyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(2-methylquinolin-5-yl)acetyl]-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; tert-butyl N-[(5- {2- [4-fluoro-2-({phenyl[4-(propan-2-yl)phenyl]methyl}carbamoyl)pyrrolidin-1 -yl] -2-oxoethyl} -1,3,4-oxadiazol-2-yl)methyl] carbamate; 1 - {2- [5-(aminomethyl)-1,3,4-oxadiazol-2-yl] acetyl} -4-fluoro-N - {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - {2- [4-(dimethylamino)- 1H-1,2,3-triazol-1 -yl] acetyl} -4-fluoro-N- {[3-fluoro-4-(propan-2-yl)phenyl] (phenyl) methyl} pyrrolidine-2 -c arboxamide; tert-butyl 4-(5-{2-[4-fluoro-2-({ [3-fluoro-4-(propan-2- yl)phenyl] (phenyl)methyl} carbamoyl)pyrrolidin-1 -yl] -2-oxoethyl} -1H-1,2,3 -triazol-4-yl)piperazine-1-carboxylate; 4-fluoro-N- {[3-fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 -(2- {3-oxo-2H,3H- [l,2,4]triazolo[4,3-a]pyridin-8-yl}acetyl)pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - {2- [5-(trifluoromethyl)-1H-l,2,3-triazol-l-yl]acetyl}pyrrolidine-2-carboxamide; 1 - {2- [4-(dimethylamino)-2H-1,2,3-triazol-2-yl] acetyl} -4-fluoro-N- {[3-fluoro-4-(propan-2-yl)phenyl] (phenyl) methyl} pyrrolidine-2 -c arboxamide; l-[2-(3,5-dimethyl-2,4-dioxo-l,2,3,4-tetrahydropyrimidin-l-yl)acetyl]-4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}pyrrolidine-2-carboxamide; 1 - {2- [5-(difluoromethyl)-2H-1,2,3,4-tetrazol-2-yl] acetyl} -4-fluoro-N- {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 1 - {2- [5-(acetamidomethyl)-1,3,4-oxadiazol-2-yl] acetyl} -4-fluoro-N - {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 1 - {2- [5-(aminomethyl)-1H-1,2,3-triazol-1 -yl] acetyl} -4-fluoro-N - {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; l-(2-{5-[(dimethylamino)methyl]-lH-l,2,3-triazol-l-yl}acetyl)-4-fluoro-N-{phenyl[4-(propan-2-yl)phenyl]rnethyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - {2 - [4-(piperazin- l-yl)-lH-l,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - {2- [4-(morpholin-4-yl)-1H-l,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide; 1 -(2- {5- [(dimethylamino)methyl] -1,3,4-oxadiazol-2-yl} acetyl)-4-fluoro-N - {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-(4H-1,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(4H-1,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 H-indazol-3 - yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - {2- [5-(trifluoromethyl)-1H- 1,2,3,4-tetrazol-l-yl] acetyl }pyrrolidine-2-carboxamide; 1 - [2-( 1H-1,2,3 -benzotriazol-1 -yl)acetyl] -N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-[2-(3-methyl-2-oxo-2,3-dihydro-lH-l,3-benzodiazol-l-yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(3 -methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(2-oxo-2,3 -dihydro-1H-1,3 -benzodiazol-l-yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 -oxo-2,3 -dihydro-1H- isoindol-2-yl)acetyl]pyrrolidine-2-carboxamide; N-[2-(2-{[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carbamoyl}-4-fluoropyrrolidin-l-yl)-2-oxoethyl]morpholine-4-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 -methyl-1 H-indol-3 -yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 -methyl-1 H-indol-2-yl)acetyl]pyrrolidine-2-carboxamide; 2-(2-{[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carbamoyl}-4-fluoropyrrolidin-l-yl)-2-oxoethyl azetidine-1-carboxylate; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 -methyl-1 H-indazol-3 -yl)acetyl]pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-[2-(2-oxo-2,3-dihydro-lH-indol-1 -yl) acetyl] pyrrolidine-2 -carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(2-methyl-1H-1,3 -benzodiazol-l-yl)acetyl]pyrrolidine-2-carboxamide; 1 - {2- [5-(acetamidomethyl)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoro-N - {phenyl[4-(propan-2-yl)phenyl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1 - [2-(5-oxo-4,5-dihydro- 1H-1,2,4-triazol-3 -yl)acetyl] -N- {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-[2-(5-oxo-4,5-dihydro-lH-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-[2-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)acetyl]pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-[2-(l-methyl-2-oxo-2,3-dihydro-lH-indol-3-yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(4-methyl-1 H-imidazol-1 -yl)acetyl]pyrrolidine-2-carboxamide; 1 - {2- [5-(difluoromethyl)- 1H-1,2,3,4-tetrazol-1 -yl] acetyl} -4-fluoro-N- {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 2-(2-{[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carbamoyl}-4-fluoropyrrolidin-l-yl)-2-oxoethyl 4-(cyclopropylmethyl)piperazine-1 -carboxylate; 2-(2-{[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carbamoyl}-4-fluoropyrrolidin-l-yl)-2-oxoethyl 4-methylpiperazine-1-carboxylate; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-[2-(2-oxo-2,3-dihydro-lH-indol-3 -yl) acetyl] pyrrolidine-2 -carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 -(2- {imidazo [ 1,2-a]pyridin-3 - yl} acetyl)pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-(2-{[l,2,4]triazolo[l,5-a]pyridin-6-yl} acetyl)pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - {2- [4-(trifluoromethyl)-1H- l,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-{2-[(pyrazin-2-yl)amino] acetyl }pyrrolidine-2-carboxamide; 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - {2- [4-(piperazin- l-yl)-lH- l,2,3-triazol-l-yl]acetyl}pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -1 - {2- [(2-ethyl-2H-1,2,3 -triazol-4-yl)amino] acetyl }-4-fluoropyrrolidine-2-carboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-[2-(5-methyl-2,4-dioxo- l,2,3,4-tetrahydropyrimidin-l-yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -1 - {2- [(1 -ethyl-1H-1,2,3 -triazol-4-yl)amino] acetyl}-4-fluoropyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(2-methylquinolin-6-yl)acetyl]pyrrolidine-2-carboxamide; 2-(2-{[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carbamoyl}-4-fluoropyrrolidin-l-yl)-2-oxoethyl 4-(2-methoxyethyl)piperazine-l-carboxylate; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - {2- [2-oxo-4-(2,2,2-trifluoroethyl)piperazin-1 -yl] acetyl }pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-{2-[methyl(2-methylpyrimidin-4-yl)amino] acetyl }pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-(2-methylquinolin-5-yl)acetyl]pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-{2-[(2-methylpyrimidin-4-yl)amino] acetyl }pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)acetyl]-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - {2- [methyl(pyrazin-2- yl)amino] acetyl }pyrrolidine-2-carboxamide; 4-fluoro-1-(2-{3-oxo-2H,3H-[ 1,2,4]triazolo[4,3-a]pyridin-8-yl}acetyl)-N-{phenyl[5-(propan-2- yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 2-(2-{[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carbamoyl}-4-fluoropyrrolidin-l-yl)-2- oxoethyl 4-(2,2,2-trifluoroethyl)piperazine-1-carboxylate; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(4H-l,2,4-triazol-4- yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-[2-(4H-l,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide; 1 - [2-( 1H-1,3 -benzodiazol-1 -yl)acetyl] -N- [(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -4-fluoropyrrolidine-2-carboxamide; l-[2-(lH-l,3-benzodiazol-l-yl)acetyl]-4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2- yl] (phenyl)methyl }pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-l-{2-[4-(dimethylamino)-2H-l,2,3-triazol-2-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-1- {2-[4-(dimethylamino)- 1H-1,2,3-triazol-1-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide; l-{2-[4-(dirnethylamino)-lH-l,2,3-triazol-l-yl]acetyl}-4-fluoro-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-(2-{3-oxo-2H,3H-[l,2,4]triazolo[4,3-a]pyridin-8-yl}acetyl)pyrrolidine-2-carboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-1-(2-{3-oxo-2H,3H- [l,2,4]triazolo[4,3-a]pyridin-8-yl}acetyl)pyrrolidine-2-carboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-[2-(2-methylquinolin-5- yl)acetyl]pyrrolidine-2-carboxamide; tert-butyl 2-[2-(2-{[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]carbamoyl}-4- fluoropyrrolidin-l-yl)-2-oxoethyl]-lH-indole-l-carboxylate; l-{2-[4-(dimethylamino)-2H-l,2,3-triazol-2-yl]acetyl}-4-fluoro-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1 H-indol-2-yl)acetyl]pyrrolidine-2-carboxamide; l-[2-(carbamoylamino)acetyl]-4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2- yl] (phenyl)methyl }pyrrolidine-2-carboxamide; l-{2-[4-(dirnethylarnino)-lH-l,2,3-triazol-l-yl]acetyl}-4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -1 - {2- [(2-ethyl-2H-1,2,3 -triazol-4-yl)(methyl)amino] acetyl }-4-fluoropyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -1 - {2- [(1 -ethyl-1H-1,2,3 -triazol-4-yl)(methyl)amino] acetyl }-4-fluoropyrrolidine-2-carboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(5-methyl-2,4-dioxo-l,2,3,4-tetrahydropyrimidin-l-yl)acetyl]pyrrolidine-2-carboxamide; N - [(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -1 - {2- [4-(dimethylamino)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide; 1 - {2- [4-(dimethylamino)-2H-1,2,3-triazol-2-yl] acetyl} -4-fluoro-N- {[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}pyrrolidine-2-carboxamide; N - [(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -1 - {2- [5-(dimethylamino)-1H-1,2,3 -triazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide; 4-fluoro-N- {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]-l-[2-(4H-1,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] -4-fluoro-1 - [3 -(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propanoyl]pyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-[2-(4-methyl-5-oxo-4,5-dihydro-l,2,4-oxadiazol-3-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)acetyl]-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 1 - {2- [(dimethylcarbamoyl)amino] acetyl} -4-fluoro-N- {[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl }pyrrolidine-2-carboxamide; 4-fluoro- l-{2-[(methylcarbamoyl)amino]acetyl}-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-{2-[(2-methylpyrimidin-4-yl)amino] acetyl }pyrrolidine-2-carboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-{2-[(methylcarbamoyl)amino] acetyl }pyrrolidine-2-carboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-[2-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetyl]pyrrolidine-2-carboxamide; 1 - {2- [(azetidine-1 -carbonyl)amino] acetyl} -4-fluoro-N- {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 1 - {2- [(azetidine-1 -carbonyl)amino] acetyl} -4-fluoro-N- {[6-fluoro-5 -(propan-2-yl)pyridin-2- yl] (phenyl)methyl }pyrrolidine-2-carboxamide; 4-fluoro-1 - {2- [(2-methylpyrimidin-4-yl)amino] acetyl} -N- {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; N - [(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -1 - {2- [(dimethylcarbamoyl)amino] acetyl }-4-fluoropyrrolidine-2-carboxamide; l-[2-(carbamoylamino)acetyl]-4-fluoro-N-{phenyl[5-(propan-2-yl)pyridin-2- yl]methyl}pyrrolidine-2-carboxamide; 4-fluoro- l-[2-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetyl]-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[3-(5-oxo-4,5-dihydro-lH-l,2,4-triazol-3-yl)propanoyl]-N-{phenyl[5-(propan-2- yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; l-[2-(carbamoylamino)acetyl]-N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoropyrrolidine-2-carboxamide; 1 - {2- [(azetidine-1 -carbonyl)amino] acetyl} -N- [(5-cyclopropyl-6-fluoropyridin-2- yl)(phenyl)methyl]-4-fluoropyrrolidine-2-carboxamide; N - [(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -4-fluoro-1 - {2-[(methylcarbamoyl)amino] acetyl }pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(l-methyl-5-oxo-4,5-dihydro-lH-l,2,4-triazol-3-yl)acetyl]-N-{phenyl[5-(propan- 2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N- {[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-[2-(4-methyl-5-oxo-4,5-dihydro-1,2,4 -oxadiazol- 3 -yl) acetyl] pyrrolidine-2 -c arboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-{2-[(2-methylpyrimidin-4-yl)amino] acetyl }pyrrolidine-2-carboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetyl]pyrrolidine-2-carboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(l,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-1 -[2-( 1,3-oxazol-2-yl)acetyl] -N- {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-{2-[5-(difluoromethyl)-lH-l,2,3,4-tetrazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide; 1 - {2-[5-(difluoromethyl)-1H-1,23 / l-tetrazol-1-yl] acetyl}-4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}pyrrolidine-2-carboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(l-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N- {[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl} -1 -[2-( 1 -methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-{2-[4-(trifluoromethyl)-lH-l,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}-l-{2-[4-(trifluoromethyl)-lH-1,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide; 1 - {2- [(dimethylcarbamoyl)amino]propanoyl} -4-fluoro-N - {[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl }pyrrolidine-2-carboxamide; N - [(4-cyclopropyl-3 -fluorophenyl)(phenyl)methyl] - l- {2-[(3,3 -difluoroazetidine-1 -carbonyl)amino] acetyl}-4-fluoropyrrolidine-2-carboxamide; N-[(4-cyclopropyl-3-fluorophenyl)(phenyl)methyl]-4-fluoro-l-(2-{[3-(trifluoromethyl)azetidine-1 -carbonyl] amino} acetyl)pyrrolidine-2-carboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-{2-[4-(trifluoromethyl)-lH-l,2,3-triazol-5-yl]acetyl]pyrrolidine-2-carboxamide; N - [(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -1 - {2- [(dimethylcarbamoyl)amino]propanoyl}-4-fluoropyrrolidine-2-carboxamide; 4-fluoro-l-[2-(5-methyl-l,3-oxazol-2-yl)acetyl]-N-{phenyl[5-(propan-2-yl)pyridin-2- yl]methyl}pyrrolidine-2-carboxamide; l-{2-[(dimethylcarbamoyl)amino]propanoyl}-4-fluoro-N-{phenyl[5-(propan-2-yl)pyridin-2- yl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-[2-(5-methyl-l,3-oxazol-2-yl) acetyl] pyrrolidine-2 -carboxamide; N - [(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -4-fluoro-1 - [2-(5-methyl-1,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-[2-(l,3-oxazol-2- yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-4-yl)acetyl]-N-{phenyl[5-(propan-2- yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 4-fluoro-1-(3-{3-oxo-2H,3H-[ 1,2,4]triazolo[4,3-a]pyridin-2-yl]propano yl)-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 1 - {2- [(3,3 -difluoroazetidine-1 -carbonyl)amino] acetyl] -4-fluoro-N- {phenyl [5-(propan-2- yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; 4-nuoro-N-{phcnyl[5-(propan-2-yl)pyridin-2-yl] methyl}-!-(2-{[3-(trifluoromcthyl)azctidinc-l-carbonyl] amino} acetyl)pyrrolidine-2-carboxamide; 4-fluoro-N- {[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-[2-(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide; 1 - {2- [(3,3 -difluoroazetidine-1 -carbonyl)amino] acetyl } -4-fluoro-N- {[6-fluoro-5-(propan-2- yl)pyridin-2-yl](phenyl)methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(4-methyl-5-oxo-4,5-dihydro-lH-l,2,4-triazol-3-yl)acetyl]-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; N - [(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] - l- {2-[(3,3 -difluoroazetidine-1 -carbonyl)amino] acetyl }-4-fluoropyrrolidine-2-carboxamide; N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]-3-[2-(lH-l,2,3-triazol-5-yl)acetyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide; 5-methyl-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}-l-[2-(lH-l,2,3-triazol-5- yl)acetyl]pyrrolidine-2-carboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(4-methyl-l,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-1-(2-{3-oxo-2H,3H-[l,2,4]triazolo[4,3-a]pyridin-8-yl}acetyl)pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(4-methyl-l,3-oxazol-2-yl)acetyl]-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)acetyl]pyrrolidine-2-carboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-[2-(4-methyl-l,3-oxazol-2-yl) acetyl] pyrrolidine-2 -carboxamide; 4-fluoro-N- {phenyl[5-(propan-2-yl)pyridin-2-yl] methyl } -1 - [2-( 1 H-pyrazol-1 -yl)acetyl]pyrrolidine-2-carboxamide; 1 - {2- [4-(3,3 -difluoroazetidin-1 -yl)-2H-1,2,3 -triazol-2-yl] acetyl} -4-fluoro-N- {[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}pyrrolidine-2-carboxamide; 1 - {2- [4-(diethylamino)-2H-1,2,3 -triazol-2-yl] acetyl} -4-fluoro-N - {[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}pyrrolidine-2-carboxamide; N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-5-methyl-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide; l-{2-[4-(3,3-difluoroazetidin-l-yl)-2H-l,2,3-triazol-2-yl]acetyl]-4-fluoro-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; N - [(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -4-fluoro-1 - {2- [(1,3 -oxazol-2-yl)amino] acetyl }pyrrolidine-2-carboxamide; N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl]-3-[2-(lH-l,2,3-triazol-5-yl)acetyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-l-{2-[4-(3,3-difluoroazetidin-l-yl)-2H-l,2,3-triazol-2-yl]acetyl}-4-fluoropyrrolidine-2-carboxamide; 1 - {2- [4-(diethylamino)-2H-1,2,3 -triazol-2-yl] acetyl} -4-fluoro-N - {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; N - [(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl] -1 - {2- [4-(diethylamino)-2H-1,2,3-triazol-2-yl] acetyl} -4-fluoropyrrolidine-2-carboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-5-methyl-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide; 1 - {2- [4-(azetidin-1 -yl)-2H-1,2,3-triazol-2-yl] acetyl} -4-fluoro-N- {phenyl[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide; 1 - {2- [4-(azetidin-1 -yl)-2H-1,2,3 -triazol-2-yl] acetyl} -N - [(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoropyrrolidine-2-carboxamide; 1 - {2- [4-(azetidin-1 -yl)-2H-1,2,3 -triazol-2-yl] acetyl} -4-fluoro-N- {[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}pyrrolidine-2-carboxamide; 4-fluoro-l-[2-(5-methyl-2-oxo-2,3-dihydro-l,3,4-oxadiazol-3-yl)acetyl]-N-{phenyl[5-(propan-2-yl)pyridin-2-yl]methyl}pyrrolidine-2-carboxamide; N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(5-methyl-2-oxo-2,3-dihydro-1,3,4 -oxadiazol- 3 -yl) acetyl] pyrrolidine-2 -c arboxamide; 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl]-l-[2-(5-methyl-2-oxo-2,3-dihydro-1,3,4-oxadiazol-3 -yl)acetyl]pyrrolidine-2-carboxamide; and N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(phenyl)methyl]-3-[2-(lH-l,2,3-triazol-5-yl)acetyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-(5-methyl-2-oxo-2,3-dihydro-l,3,4-oxadiazol-3-yl)acetyl]pyrrolidine-2-carboxamide 1 - {2- [(azetidine-1 -carbonyl)amino] acetyl} -N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoropyrrolidine-2-carboxamide l-[2-(lH-l,3-benzodiazol-l-yl)acetyl]-N-{ [5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoropyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-( 1,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-(5-methyl-2,4-dioxo-l,2,3,4-tetrahydropyrimidin-l-yl)acetyl]pyrrolidine-2-carboxamide N- {[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -1 - {2-[(dimethylcarbamoyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-(1 H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-(5-methyl-l,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoro-1-{2-[4-(trifluoromethyl)-lH-l,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-(4-methyl- l,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 1 - {2- [(3,3 -difluoroazetidine-1 -carbonyl)amino] acetyl } -N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoropyrrolidine-2-carboxamide N-{ [5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl](phenyl)methyl}-l-{2-[5-(difluoromethyl)- 1H-1,2,3,4-tetrazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide N- {[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -1 -[2-(2,4-dioxo-1,2,3,4- tetrahydropyrimidin-1 -yl)acetyl] -4-fluoropyrrolidine-2-carboxamide N-{ [5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl](phenyl)methyl}-l-[2-(3-ethyl-2,4-dioxo- 1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide N- {[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-(6-oxo-1,6-dihydropyridin-3-yl)acetyl]pyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-(2-oxo-1,2-dihydropyridin-3-yl)acetyl]pyrrolidine-2-carboxamide N-{ [5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl](phenyl)methyl}-l-[2-(3-ethyl-5-methyl- 2,4-dioxo-l,2,3,4-tetrahydropyrimidin-l-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide N- {[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -1 -[2-( 1 -ethyl-6-oxo-1,6-dihydropyridin-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)acetyl]pyrrolidine-2-carboxamide N-{ [5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl](phenyl)methyl}-l-[2-(l-ethyl-5-methyl-6-oxo-1,6-dihydropyridin-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide N-{ [5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl](phenyl)methyl}-l-[2-(6-ethoxy-5- methylpyridin-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide N-{ [5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl](phenyl)methyl}-l-[2-(l-ethyl-5-methyl-2-oxo-1,2-dihydropyridin-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl } -1 - [2-( 1 -ethyl-2-oxo-1,2-dihydropyridin-3-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide N-{[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl](phenyl)methyl}-l-[2-(4-ethyl-5-oxo-4,5-dihydropyrazin-2-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoro-1-{2-[4- (trifluoromethyl)-l,3-oxazol-2-yl]acetyl}pyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)-6-fluoropyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-(3 -oxo-3,4-dihydropyrazin-2-yl)acetyl]pyrrolidine-2-carboxamide N-{[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl](phenyl)methyl}-4-fluoro-l-[2-(5-oxo-4,5-dihydropyrazin-2-yl)acetyl]pyrrolidine-2-carboxamide N-{[5-(3,3-difluorocyclobutyl)-6-fluoropyridin-2-yl](phenyl)methyl}-l-[2-(4-ethyl-3-oxo-3,4-dihydropyrazin-2-yl)acetyl]-4-fluoropyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl} -1 - {2-[(dimethylcarbamoyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 1 - {2- [(azetidine-1 -carbonyl)amino] acetyl } -N- {[5-(3,3 -difluorocyclobutyl)pyridin-2- yl] (phenyl)methyl} -4-fluoropyrrolidine-2-carboxamide N-{[5-(3,3-difluorocyclobutyl)pyridin-2-yl](phenyl)methyl}-4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N-{ [5-(3,3-difluorocyclobutyl)pyridin-2-yl](phenyl)methyl}-4-fluoro-l-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-(5-methyl-1,3- oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 1 - [2-( 1H-1,3 -benzodiazol-1 -yl)acetyl] -N- {[5-(3,3 -difluorocyclobutyl)pyridin-2- yl] (phenyl)methyl} -4-fluoropyrrolidine-2-carboxamide 1 - {2- [(3,3 -difluoroazetidine-1 -carbonyl)amino] acetyl } -N- {[5-(3,3 -difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl} -4-fluoropyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-( 1,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide N- {[5-(3,3 -difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-(4-methyl-1,3- oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide N-{[5-(3,3-difluorocyclobutyl)pyridin-2-yl](phenyl)methyl}-4-fluoro-l-[2-(5-methyl-2-oxo-2,3-dihydro-1,3,4 -oxadiazol- 3 -yl) acetyl] pyrrolidine-2 -c arboxamide N- {[5-(3,3-difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - {2-[4-(trifluoromethyl)-lH-l,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide N- {[5-(3,3-difluorocyclobutyl)pyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - {2-[4-(trifluoromethyl)-l,3-oxazol-2-yl] acetyl }pyrrolidine-2-carboxamide 1 - {2- [(azetidine-1 -carbonyl)amino] acetyl }-N-{[4-(3,3 -difluorocyclobutyl)-3 -fluorophenyl] (phenyl)methyl} -4-fluoropyrrolidine-2-carboxamide N- {[4-(3,3 -difluorocyclobutyl)-3 -fluorophenyl] (phenyl)methyl} -1 - {2-[(dimethylcarbamoyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide l-[2-(lH-l,3-benzodiazol-l-yl)acetyl]-N-{ [4-(3,3-difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl} -4-fluoropyrrolidine-2-carboxamide N-{ [4-(3,3-difluorocyclobutyl)-3-fluorophenyl](phenyl)methyl}-4-fluoro-l-[2-(5-methyl-1,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide N-{[4-(3,3-difluorocyclobutyl)-3-fluorophenyl](phenyl)methyl]-4-fluoro-l-[2-(5-methyl-2,4-dioxo-l,2,3,4-tetrahydropyrimidin-l-yl)acetyl]pyrrolidine-2-carboxamide N-{ [4-(3,3-difluorocyclobutyl)-3-fluorophenyl](phenyl)methyl]-4-fluoro-l-[2-(l,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide N- {[4-(3,3-difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl} -4-fluoro-1 - {2- [4-(trifluoromethyl)-lH-l,2,3-triazol-5-yl]acetyl}pyrrolidine-2-carboxamide N-{ [4-(3,3-difluorocyclobutyl)-3-fluorophenyl](phenyl)methyl}-4-fluoro-l-[2-(4-methyl-1,3-oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide N- {[4-(3,3-difluorocyclobutyl)-3-fluorophenyl] (phenyl)methyl} -4-fluoro-1 - {2- [4-(trifluoromethyl)-l,3-oxazol-2-yl]acetyl}pyrrolidine-2-carboxamide 4-fluoro-N-{[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl)methyl}-l-[2-(5-methyl-2,4-dioxo-l,2,3,4-tetrahydropyrimidin-l-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (phenyl)methyl }-l-[2-(lH-l ,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (pyridin-3 -yl)methyl} -1 - [2-(1 H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 2-[4-fluoro-2-({[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl)methyl}carbamoyl)pyrrolidin-l-yl]-2-oxoethyl azetidine-1-carboxylate 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (phenyl)methyl } -1 - [2-( 1 -methyl-1H-indol-2-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (phenyl)methyl} -1 - [2-(2-oxopiperazin-1 -yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (phenyl)methyl } -1 - [2-( 1 -methyl-1H-indol-3-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (phenyl)methyl } -1 - [2-( 1 -methyl-1H- indazol-3-yl)acetyl]pyrrolidine-2-carboxamide N-{2-[4-fluoro-2-({[3-fluoro-4-(l- methylcyclopropyl)phenyl] (phenyl)methyl} carbamoyl)pyrrolidin-1 -yl] -2-oxoethyl} morpholine-4-carboxamide 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (phenyl)methyl} -1 - [2-(2-methyl-1H-1,3 -benzodiazol-l-yl)acetyl]pyrrolidine-2-carboxamide 1 - [2-( 1H-1,3 -benzodiazol-1 -yl)propanoyl] -4-fluoro-N- {[3 -fluoro-4-( 1 -methylcyclopropyl)phenyl](phenyl)methyl}pyrrolidine-2-carboxamide 4-fluoro-N-{[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl)methyl}-l-[2-(3-methyl-2-oxo- 2,3-dihydro-1H-1,3-benzodiazol-l-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N-{[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl)methyl}-l-[2-(3-methyl-2,4-dioxo-l,2,3,4-tetrahydropyrimidin-l-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl)methyl}-l-[2-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (phenyl)methyl } -1 - [2-( 1 H-indazol-3 -yl)acetyl]pyrrolidine-2-carboxamide 1 -[2-(2,5-dioxopiperazin-1 -yl)acetyl] -4-fluoro-N- {[3-fluoro-4-( 1 -methylcyclopropyl)phenyl](phenyl)methyl}pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (phenyl)methyl } -1 - [2-( 1 -oxo-2,3 -dihydro-lH-isoindol-2-yl)acetyl]pyrrolidine-2-carboxamide 1 - [2-( 1H-1,2,3 -benzotriazol-1 -yl)acetyl] -4-fluoro-N- {[3 -fluoro-4-( 1 -methylcyclopropyl)phenyl](phenyl)methyl}pyrrolidine-2-carboxamide 4-fluoro-N-{[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl)methyl}-l-[2-(2-oxo-2,3- dihydro-lH-indol-l-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (phenyl)methyl } -1 - [2-( 1 -methyl-2-oxo- 2,3-dihydro-lH-indol-3-yl)acetyl]pyrrolidine-2-carboxamide 2,2,2-trifluoroethyl 4-{2-[4-fluoro-2-({ [3-fluoro-4-(l- methylcyclopropyl)phenyl] (phenyl)methyl} carbamoyl)pyrrolidin-1 -yl] -2-oxoethyl} -3 - oxopiperazine-1 -carboxylate 2-[4-fluoro-2-({[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl)methyl}carbamoyl)pyrrolidin-1-yl]-2-oxoethyl 4-(2-methoxyethyl)piperazine-1-carboxylate 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (phenyl)methyl} -1 - {2- [2-oxo-4-(2,2,2- trifluoroethyl)piperazin-1 -yl] acetyl }pyrrolidine-2-carboxamide 4-fluoro-N- {[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl)methyl}-l-[2-(2-oxo-2,3- dihydro-lH-indol-3-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (phenyl)methyl} -1 - [2-(4H-1,2,4-triazol-4-yl)acetyl]pyrrolidine-2-carboxamide 2-[4-fluoro-2-({[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl)methyl]carbamoyl)pyrrolidin-1-yl]-2-oxoethyl 4-methylpiperazine-1-carboxylate 2-[4-fluoro-2-({[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl)methyl]carbamoyl)pyrrolidin- 1-yl]-2-oxoethyl 4-(cyclopropylmethyl)piperazine-1-carboxylate 2-[4-fluoro-2-({[3-fluoro-4-(l-methylcyclopropyl)phenyl](phenyl)methyl]carbamoyl)pyrrolidin-1-yl]-2-oxoethyl 4-(2,2,2-trifluoroethyl)piperazine-l-carboxylate 1 - [2-( 1H-1,3 -benzodiazol-1 -yl)propanoyl] -4-fluoro-N- {[6-fluoro-5-( 1 - methylcyclopropyl)pyridin-2-yl](phenyl)methyl}pyrrolidine-2-carboxamide 4-fluoro-N- {[6-fluoro-5-( 1 - methylcycloprop yl)pyridin-2-yl] (phenyl)methyl } -1 - [2-( 1 H-indazol- 3 -yl) acetyl] pyrrolidine-2 -carboxamide N-{2-[4-fluoro-2-({[6-fluoro-5-(l-methylcyclopropyl)pyridin-2- yl] (phenyl)methyl} carbamoyl)pyrrolidin-1 -yl] -2-oxoethyl} morpholine-4-carboxamide 4-fluoro-N- {[6-fluoro-5-( 1 - methylcycloprop yl)pyridin-2-yl] (phenyl)methyl } -1 - [2-( 1 -methyl-1H- indol-2-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[6-fluoro-5-( 1 - methylcycloprop yl)pyridin-2-yl] (phenyl)methyl } -1 - [2-( 1 -methyl-1H-indol-3-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[6-fluoro-5-( 1 - methylcycloprop yl)pyridin-2-yl] (phenyl)methyl} -1 - [2-(2-methyl-1H-l,3-benzodiazol-l-yl)acetyl]pyrrolidine-2-carboxamide 1 - [2-( 1H-1,2,3 -benzotriazol-1 -yl)acetyl] -4-fluoro-N- {[6-fluoro-5-( 1 -methylcycloprop yl)pyridin-2-yl] (phenyl)methyl }pyrrolidine-2-carboxamide 1 -[2-( 1H-1,3-benzodiazol-1 -yl)acetyl] -4-fluoro-N - {[6-fluoro-5-( 1 -methylcyclopropyl)pyridin-2-yl] (phenyl)methyl }pyrrolidine-2-carboxamide 4-fluoro-N- {[6-fluoro-5-( 1 - methylcycloprop yl)pyridin-2-yl] (phenyl)methyl } -1 - [2-( 1 -methyl-1H-indazol-3-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[6-fluoro-5-( 1 - methylcycloprop yl)pyridin-2-yl] (phenyl)methyl } -1 - [2-( 1 -methyl-2- oxo-2,3-dihydro-lH-indol-3-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[6-fluoro-5-( 1 - methylcycloprop yl)pyridin-2-yl] (phenyl)methyl } -1 - [2-( 1 H-indol-2-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[6-fluoro-5-( 1 -methylcyclopropyl)pyridin-2-yl] (phenyl)methyl} -1 - [2-(2-oxo-2,3- dihydro-1H-1,3-benzodiazol-1 -yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[6-fluoro-5-( 1 - methylcycloprop yl)pyridin-2-yl] (phenyl)methyl} -1 - [2-(3-methyl-2-oxo-2,3-dihydro-lH-l,3-benzodiazol-l-yl)acetyl]pyrrolidine-2-carboxamide tert-butyl 2-{2-[4-fluoro-2-({[6-fluoro-5-(l-methylcyclopropyl)pyridin-2- yl] (phenyl)methyl} carbamoyl)pyrrolidin-1 -yl] -2-oxoethyl} -1 H-indole-1 -carboxylate 1 - {2- [5-(difluoromethyl)-1,3,4-oxadiazol-2-yl] acetyl} -4-fluoro-N - {[4-methyl-5-(propan-2- yl)pyridin-2-yl](phenyl)methyl}pyrrolidine-2-carboxamide l-acetyl-N-[(5-cyclobutylpyridin-2-yl)(phenyl)methyl]-4-fluoropyrrolidine-2-carboxamide 4-fluoro-N- {[4-methyl-5 -(propan-2-yl)pyridin-2-yl] (phenyl)methyl } -1 - [2-( 1H-1 ,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[4-fluoro-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}-l-[2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N- {[4-(difluoromethyl)-5-(propan-2-yl)pyridin-2-yl] (phenyl)methyl} -4-fluoro-1 - [2-( 1H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[6-methyl-5 -(propan-2-yl)pyridin-2-yl] (phenyl)methyl } -1 - [2-( 1H-1 ,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {phenyl[5-(propan-2-yl)-4-(trifluoromethyl)pyridin-2-yl]methyl}-l-[2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 1 - {2 - [5-(difluoromethyl)-1,3,4-oxadiazol-2-yl] acetyl} -4-fluoro-N - {[6-methyl-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl}pyrrolidine-2-carboxamide N - [(5-cyclobutylpyridin-2-yl)(phenyl)methyl] -4-fluoro-1 - [2-( 1H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N-[(5-tert-butylpyridin-2-yl)(phenyl)methyl]-4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N-{[6-methoxy-5-(propan-2-yl)pyridin-2-yl](phenyl)methyl]-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N-[(2-aminopyridin-3-yl)[3-fluoro-4-(propan-2-yl)phenyl]methyl]-4-fluoro-l-[2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N - [(4-cyclopropyl-3 -fluorophenyl)( 1 H-pyrazol-5-yl)methyl] -1 -(2-acetamidoacetyl)pyrrolidine-2-carboxamide 4-fluoro-N- {[3-fluoro-4-(propan-2-yl)phenyl](5-fluoropyridin-2-yl)methyl} -1-[2-( 1H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (5-fluoropyridin-3 -yl)methyl} -1 - [2-(1 H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N-[(2-aminopyridin-4-yl)[3-fluoro-4-(propan-2-yl)phenyl]methyl]-4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3-fluoro-4-(propan-2-yl)phenyl](3-fluorop yridin-4-yl)methyl} -1-[2-( 1H-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N-[(6-aminopyridin-3-yl)[3-fluoro-4-(propan-2-yl)phenyl]methyl]-4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N-[(6-aminopyridin-2-yl)[3-fluoro-4-(propan-2-yl)phenyl]methyl]-4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N-[(2-aminopyridin-3-yl)[3-methyl-4-(propan-2-yl)phenyl]methyl]-l-{2-[(dimethylcarbamoyl)amino] acetyl} -4-fluoropyrrolidine-2-carboxamide 4-fluoro-N-{[3-fluoro-4-(propan-2-yl)phenyl](lH-pyrazol-5-yl)methyl}-l-[2-(lH-l,2,3-triazol-5 -yl) acetyl] pyrrolidine-2 -carboxamide N-[(2-aminopyridin-3-yl)[3-methyl-4-(propan-2-yl)phenyl]methyl]-4-fluoro-l-[2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N-[(2-aminopyridin-3-yl)[3-methyl-4-(propan-2-yl)phenyl]methyl]-4-fluoro-l-[2-(l,3,5-trimethyl- lH-pyrazol-4-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N-{[3-fluoro-4-(l-methylcyclopropyl)phenyl](2-methoxypyridin-3-yl)methyl}-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-( 1 - methylcycloprop yl)phenyl] (2-methylpyridin-3 -yl)methyl } -1 - [2-( 1H-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl]({imidazo[l,5-a]pyridin-3-yl})methyl}-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl]({imidazo[l,5-a]pyridin-l-yl})methyl}-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[6-fluoro-5-(propan-2-yl)pyridin-2-yl] (1 H-pyrazol-5-yl)methyl } -1 - [2-( 1 ,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl]({imidazo[l,5-a]pyridin-7-yl})methyl}-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[6-fluoro-5-(propan-2-yl)pyridin-2-yl](lH-indazol-6-yl)methyl}-l-[2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide l-acetyl-4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](lH-indazol-6-yl)methyl}pyrrolidine-2-carboxamide l-acetyl-4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](l-methyl-lH-indazol-6-yl)methyl}pyrrolidine-2-carboxamide l-acetyl-4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](2-methyl-2H-indazol-6-yl)methyl}pyrrolidine-2-carboxamide l-acetyl-N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(lH-indazol-6-yl)methyl]-4-fluoropyrrolidine-2-carboxamide methyl N-({3-[({4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidin-2-yl}formamido)[6-fluoro-5-(propan-2-yl)pyridin-2-yl]methyl]phenyl}methyl)carbamate l-acetyl-N-[(2-methoxyphenyl)[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide l-acetyl-N-[(2-methylphenyl)[4-(propan-2-yl)phenyl]methyl]pyrrolidine-2-carboxamide l-acetyl-N-[(2-methylphenyl)[5-(propan-2-yl)pyridin-2-yl]methyl]pyrrolidine-2-carboxamide N - [(4-cyclopropyl-3 -fluorophenyl)(2-oxo-2,3 -dihydro-1,3 -benzoxazol-7-yl)methyl] -1-(2-acetamidoacetyl)pyrrolidine-2-carboxamide N-[(2-oxo-2,3-dihydro-lH-l,3-benzodiazol-4-yl)[4-(propan-2-yl)phenyl]methyl]-l-[2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (3 -fluorophenyl)methyl} -1 - [2 - (1H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[3 -fluoro-4-(propan-2-yl)phenyl] (4-fluorophenyl)methyl} -1 - [2 - (1H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N-[(4-cyclopropyl-3-fluorophenyl)(2-oxo-2,3-dihydro-lH-l,3-benzodiazol-4-yl)methyl]-l-[2- (lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N - [(3 -acetamidophenyl) [4-(propan-2-yl)phenyl] methyl] -4-fluoro-1 - [2-( 1 -methyl-1H-1,2,3 -triazol-4-yl)acetyl]pyrrolidine-2-carboxamide N - [(4-cyclopropyl-3 -fluorophenyl)( 1 -methyl-2-oxo-2,3 -dihydro-1H-1,3 -benzodiazol-4-yl)methyl]-4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[6-fluoro-5-(propan-2-yl)pyridin-2-yl](3-methoxyphenyl)methyl]-l-[2-(lH-1,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N-{cyclopropyl[3-fluoro-4-(propan-2-yl)phenyl]methyl}-4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N- {2-cyclopropyl-1 - [3 -fluoro-4-(propan-2-yl)phenyl] ethyl} -4-fluoro-1 - [2-( 1H-1,2,3 -triazol-5-yl)acetyl]pyrrolidine-2-carboxamide l-acetyl-4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](3-methoxyphenyl)methyl}pyrrolidine-2-carboxamide N-{[3-(acetamidomethyl)phenyl][6-fluoro-5-(propan-2-yl)pyridin-2-yl]methyl}-4-fluoro-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N-{[6-fluoro-5-(propan-2-yl)pyridin-2-yl](3- {[(methylcarbamoyl)amino]methyl}phenyl)methyl}-l-[2-(lH-l,2,3-triazol-5-yl)acetyl]pyrrolidine-2-carboxamide N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(2-fluorophenyl)methyl]-l-{2-[5-(difluoromethyl)-lH- 1,2,3,4-tetrazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide N-[(5-cyclopropyl-6-fluoropyridin-2-yl)(4-fluorophenyl)methyl]-l-{2-[5-(difluoromethyl)-lH- 1,2,3,4-tetrazol-1 -yl] acetyl} -4-fluoropyrrolidine-2-carboxamide N- {[3,5-difluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -4-fluoro-1 - [(1H-1,2,3 -triazol-5-yl)methanesulfonyl]pyrrolidine-2-carboxamide l-acetyl-N-[(4-cyclobutyl-3-fluorophenyl)(phenyl)methyl]-4-fluoropyrrolidine-2-carboxamide N- {[3,5-difluoro-4-(propan-2-yl)phenyl] (phenyl)methyl} -4-fluoro-1 - [2-( 1,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide N - [(4-cyclopropyl-3,5-difluorophenyl)(phenyl)methyl] -4-fluoro-1 - [2-( 1,3 -oxazol-2-yl)acetyl]pyrrolidine-2-carboxamide 4-fluoro-N- {[2-methyl-4-(propan-2-yl)phenyl] (phenyl)methyl} -1 - [2-( 1,3 -oxazol-2- yl)acetyl]pyrrolidine-2-carboxamide N-[(3-chloro-4-cyclopropylphenyl)(phenyl)methyl]-4-fluoro-l-[2-(lH-l,2,...

Claims

1. A compound of formula (I-A), or a stereoisomer or tautomer thereof, or apharmaceutically acceptable salt of any of the foregoing:wherein:Y1 is CH or N;Rx and Rz are independently H, halo, C1-6alkyl, or -NH2, wherein, when Y1 is CH, the C1-6alkyl of Rx or Rz may be optionally substituted with one or more halo;Ry is (i) C1-6alkyl, or (ii) C3-10cycloalkyl, wherein the C3-10cycloalkyl is optionally substituted with one or more halo or C1-6alkyl;Rk is H, halo, -OH, -NH2, or -NH-C(O)C1-6alkyl;R2 is C1-6alkyl, wherein the C1-6alkyl of R2 is substituted with one or more Ra, wherein Ra is -OH or 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of Ra is optionally substituted with one or more Rb; andRb is halo, C1-6alkyl, C1-6alkoxy, -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, C3-10cycloalkyl, 3-15 membered heterocyclyl, or -C(O)-C1-6alkoxy, wherein the C1-6alkyl of Rb is optionally2022239717   30 Jul 2026substituted with one or more halo, -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NH-C(O)C1-6alkyl, or -NH-C(O)-C1-6alkoxy, and the 3-15-membered heterocyclyl of Rb is optionally substituted with one or more halo or -C(O)-C1-6alkoxy.

2. The compound of claim 1, or a stereoisomer or tautomer thereof, or apharmaceutically acceptable salt of any of the foregoing, wherein the moiety represented byhas a stereochemical configuration of the formula:

3. The compound of claim 1 or claim 2, or a stereoisomer or tautomer thereof, or apharmaceutically acceptable salt of any of the foregoing, wherein the moiety represented byis selected from the group consisting of2022239717   30 Jul 20264.     The compound of any one of claims 1-3, or a stereoisomer or tautomer thereof, or apharmaceutically acceptable salt of any of the foregoing, wherein at least one of (a) and (b) applies:(a) Rx is H, fluoro, or methyl, andRy is (i) isopropyl, or (ii) C3-4cycloalkyl, wherein the C3-4cycloalkyl is optionally substituted with one or more fluoro or methyl; and(b) Rk is H or halo.

5. The compound of any one of claims 1-4, or a stereoisomer or tautomer thereof, or apharmaceutically acceptable salt of any of the foregoing, wherein R2 is selected from the group consisting of:2022239717   30 Jul 2026, and6.     The compound of claim 1, or a stereoisomer or tautomer thereof, or apharmaceutically acceptable salt of any of the foregoing, wherein the compound is a compound of formula (I-A3):2022239717   30 Jul 2026wherein Rx is H, halo, C1-6alkyl, or -NH2.

7. The compound of claim 1, or a stereoisomer or tautomer thereof, or apharmaceutically acceptable salt of any of the foregoing, wherein the compound, or astereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of theforegoing, is selected from the group consisting of:7342022239717   30 Jul 20267352022239717 Y-z                                                                                         1 \ go              So                                                 \\ z) <0                                              ®                                                                                                                                          ' 2 / '1 » ^°nJ Arn / Y5 ’^yY / W- Yd ' d • yy ' f                           z" \ s^f        O                               yy lq      A o q o 6 'YY. = ■     \--'r--' S S                                               S o o n>                                                                      0 30 Jul 2026 »6 / r^o       3 / ' o ZZ   z=\ o 71 » Q : - i> > ,- -736o2022239717   30 Jul 2026737G G738^-NHN740742743IM2022239717   30 Jul 2026745NH747-Me748NH749N750-MeHLNH                       mN'NH753OMeai / \T7562022239717   30 Jul 20267572022239717   30 Jul 2026and8.     The compound of claim 1, or a stereoisomer or tautomer thereof, or apharmaceutically acceptable salt of any of the foregoing, wherein the compound, or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, is selected from the group consisting of:2022239717   30 Jul 2026Me;N'N9.     A pharmaceutical composition comprising (i) a compound of any one of claims 1-8,or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, and (ii) one or more pharmaceutically acceptable excipients.

10. A method of treating a GYS1-mediated disease, disorder, or condition in an individual in need thereof, comprising administering a therapeutically effective amount of a compound of any one of claims 1-8, or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or a pharmaceutical composition of claim 9.

11. The method of claim 10, wherein the disease, disorder, or condition is a glycogen storage disorder (GSD).2022239717   30 Jul 202612. The method of claim 10 or claim 11, wherein the disease, disorder, or condition is selected from the group consisting of Pompe disease, Cori disease (GSD III), adult polyglucosan body disease (APBD), and Lafora disease.

13. The method of any one of claims 10-12, wherein the disease, disorder, or condition is Pompe disease.

14. Use of a compound of any one of claims 1-8, or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or a pharmaceutical composition of claim 9, in the manufacture of a medicament for the treatment of a GYS1-mediated disease, disorder, or condition in an individual in need thereof.

15. The use of claim 14, wherein the disease, disorder, or condition is a glycogen storage disorder (GSD).

16. The use of claim 14 or claim 15, wherein the disease, disorder, or condition is selected from the group consisting of Pompe disease, Cori disease (GSD III), adult polyglucosan body disease (APBD), and Lafora disease.

17. The use of any one of claims 14-16, wherein the disease, disorder, or condition is Pompe disease.

18. A compound of any one of claims 1-8, or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, or a pharmaceutical composition of claim 9, when used in the treatment of a GYS1-mediated disease, disorder, or condition in an individual in need thereof.

19. The compound of claim 18, wherein the disease, disorder, or condition is a glycogen storage disorder (GSD).2022239717   30 Jul 202620. The compound of claim 18 or claim 19, wherein the disease, disorder, or condition is selected from the group consisting of Pompe disease, Cori disease (GSD III), adult polyglucosan body disease (APBD), and Lafora disease.

21. The compound of any one of claims 18-20, wherein the disease, disorder, or condition is Pompe disease.

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