Formulations of lipid NANO emulsions with controlled pharmacokinetic profiles and methods of making and using the same
A stable emulsion formulation of tricaprilin with Phospholipon® 90G and Kolliphor® RH40, along with a buffer, addresses stability issues in MCTs, ensuring long-term effectiveness as pharmaceutical carriers.
AU2024384650A1Pending Publication Date: 2026-07-09CERECIN AUSTRALIA PTY LTD
Patent Information
- Authority / Receiving Office
- AU · AU
- Patent Type
- Applications
- Current Assignee / Owner
- CERECIN AUSTRALIA PTY LTD
- Filing Date
- 2024-11-26
- Publication Date
- 2026-07-09
AI Technical Summary
Technical Problem
Existing formulations of medium chain triglycerides (MCTs) face stability issues over extended periods, particularly when exposed to varying temperatures, which affects their efficacy as pharmaceutical carriers and active ingredients.
Method used
A stable emulsion formulation comprising tricaprilin, emulsifiers such as Phospholipon® 90G and Kolliphor® RH40, a buffer at pH 6.0-7.5, and optional sweeteners and flavors, stabilized through high shear mixing and high-pressure homogenization, ensuring long-term stability and effective delivery.
Benefits of technology
The emulsion maintains stability for at least 3 months to 12 months at various temperatures, providing a reliable carrier for pharmaceuticals and enhancing the effectiveness of MCTs as active ingredients.
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Abstract
Provided herein are emulsion composition comprising a medium chain triglyceride (MCT), preferably tricaprilin. Also, described here are additional ingredients that make these emulsion compositions more suitable for oral intake, such as one or more emulsifiers, buffers such as phosphate buffers, as well as optionally glycerol and a sweetener and / or a flavoring agent. Described herein are methods of making and using these emulsions. The emulsions described may be used for oral administration of tricaprilin to treat and / or prevent various diseases or disorders.
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