Pyridazine compounds, their preparation and therapeutic uses.
Patent Information
- Authority / Receiving Office
- BR · BR
- Patent Type
- Applications
- Current Assignee / Owner
- SANOFI SA(FR)
- Filing Date
- 2024-03-12
- Publication Date
- 2026-07-07
Abstract
Claims
CLAIMS 1. Compound, characterized in that it has the formula (I) or a pharmaceutically acceptable salt thereof: R2 R3 where n is 1 or 2; R1 independently represent a halogen atom, a (C1-C4)alkyl group, a halo(C1-C4)alkyl group, a (C1-C4)alkoxy group, a halo(C1-C4)alkoxy group, a group of formula j = R6 where R6 is a hydrogen atom or a methyl group and the symbol i represents the bonding site between the carbon atom and the phenyl ring, or a (C1-C1)cycloalkyl group; or two R1s that are on adjacent carbon atoms form, together with the atoms that connect them, a cyclopentane ring that is fused to the phenol group; R2 and R3 independently represent a hydrogen atom, a cyano group, a (C1-C4)alkyl group, a hydroxy(C1-C4)alkyl group,a halo(C1-C4)alkyl group or a group of formula । where R6 is a hydrogen atom or a methyl group and the symbol । represents the bonding site between the carbon atom and the pyridazine ring; or R2 and R3, which are on adjacent carbon atoms, form, together with the atoms that connect them, a (CsCej)carbocyclic ring that is fused to the pyridazine ring; Petition 870250081269, dated 10 / 09 / 2025, page 736 / 792 2 / 48. R4 and R5 form, together with the nitrogen atom to which they are attached: - a 3- to 7-membered monocyclic heterocycloalkyl ring comprising a nitrogen atom and, optionally, an additional heteroatom selected from a nitrogen atom, an oxygen atom and a sulfur atom and comprising 2 to 6 carbon atoms, - an 8- to 11-membered bicyclic heterocycloalkyl ring comprising a nitrogen atom and, optionally, one to three additional heteroatoms independently selected from a nitrogen atom,- an oxygen atom and a sulfur atom comprising 4 to 10 carbon atoms, or - a 7- to 12-membered bicyclic spiro heterocyclic ring comprising a nitrogen atom and, optionally, one to three additional heteroatoms selected from among a nitrogen atom, an oxygen atom and a sulfur atom and comprising 3 to 11 carbon atoms, wherein said monocyclic heterocycloalkyl ring, bicyclic heterocycloalkyl ring and bicyclic spiro heterocyclic ring are unsubstituted or substituted by one to two substituents independently selected from among an (C1-C4)alkyl group, an NH2 group, a mono(C1-C4)alkylamino group, a di(C1-C4)alkylamino group, an NH2-(C1-C4)alkyl group, a mono(C1-C4)alkylamino-(C1-C4)alkyl group, a group di(C1-C4)alkylamino-(C1-C4)alkyl, an NH2-(C3C6)cycloalkyl group, an OH-(C3-C6)cycloalkyl group, a mono(C1C4)alkylamino-(C3-C6)cycloalkyl group, a di(C1-C4)alkylamino-(C3C6)cycloalkyl group,a (C2-C5)acylamino-(C1-C4)alkyl group, a (C2-C5)acylamino group, a (C2-C5)acyl group, a hydroxy-(C1-C4)alkyl group, a SH-(C1-C4)alkyl group, a CN-(C1-C4)alkyl group, a (C1-C4)alkoxy-(C1-C4)alkyl group, a hydroxyl group, an oxo group, a group Petition 870250081269, dated 10 / 09 / 2025, page. 737 / 792 3 / 48 (C3-C6)cycloalkyl, a halogen atom, a halo(C1-C4)alkyl group, a cyano group, an NH2-C(=O) group, a mono(C1-C4)alkylamino-C(=O) group, a di(C1-C4)alkylamino-C(=O) group, an NH2C(=O)-(C1-C4)alkyl group, a mono(C1-C4)alkylamino-C(=O)-(C1-C4)alkyl group, a di(C1-C4)alkylamino-C(=O)-(C1-C4)alkyl group or a -CO2H group.
2. Compound of formula (I) or a pharmaceutically acceptable salt thereof, according to claim 1, characterized in that n is 1:
3. Compound of formula (I) or a pharmaceutically acceptable salt thereof, according to claim 1,characterized in that n is 2:
4. Compound of formula (I) or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 3, characterized in that R1 independently represents a halogen atom, a (C1-C4)alkyl group, a (C1-C4)alkoxy group, a halo(C1-C4)alkoxy group, a (C3-C6)cycloalkyl group, . .. . I ZZ— R6 .........- . a formula group 1 wherein R6 is a hydrogen atom or a methyl group and the symbol l represents the bonding site between the carbon atom and the phenyl ring, or a halo(C1-C4)alkyl group, in particular R1 independently represents a fluorine atom, a chlorine atom, a methyl group, an ethyl group, an isopropyl group, a methoxy group, a trifluoromethoxy group, a cyclopropyl group, a -CHF2 group, an ethinyl group or a trifluoromethyl group, or two R1s that are on adjacent carbon atoms form, together with the atoms that connect them,a cyclopentane ring that is fused to the phenol group, in particular these two R1s represent a group of formula Petition 870250081269, 10 / 09 / 2025, p. 738 / 792 4 / 48 OH where the symbol * represents the bonding site between the carbon atom of the phenol ring and the carbon atom of the pyridazine ring.
5. Compound of formula (I) or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 4, characterized in that - when n is 1, R1 is in the ortho, meta or para position on the phenyl relative to the pyridazine ring, or - when n is 2, the two R1s are in the ortho and para position on the phenyl relative to the pyridazine ring, or - when n is 2, the two R1s are in the ortho and meta position on the phenyl relative to the pyridazine ring.
6. Compound of formula (I) or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 5,characterized in that R2 and R3 independently represent a hydrogen atom, a cyano group, a halo(C1-C4)alkyl group, a hydroxy(C1-C4)alkyl group or a (C1-C4)alkyl group; in particular, R2 and R3 independently represent a hydrogen atom, a cyano group, a -CHF2 group, a trifluoromethyl group, a -CH2OH group, a methyl group, an ethyl group or an isopropyl group.
7. Compound of formula (I) or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 5, characterized in that R2 and R3 which are on adjacent carbon atoms form, together with the atoms connecting them, a (C5-C6) carbocyclic ring which is fused to the pyridazine ring, in particular R2 and R3 which Petition 870250081269, dated 10 / 09 / 2025, p. 739 / 792 5 / 48 are on adjacent carbon atoms form, together with the atoms connecting them,a cyclopentyl ring that is fused to the pyridazine ring.
8. A compound of formula (I) or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 6, characterized in that R4 and R5 together with the nitrogen atom to which they are attached form: - a 4- to 7-membered monocyclic heterocycloalkyl ring comprising a nitrogen atom and, optionally, an additional heteroatom selected from among a nitrogen atom, an oxygen atom and a sulfur atom and comprising 3 to 6 carbon atoms, - an 8- to 10-membered bicyclic heterocycloalkyl ring comprising a nitrogen atom and, optionally, one or two additional heteroatoms independently selected from among a nitrogen atom, an oxygen atom and a sulfur atom and comprising 6, 7, 8 or 9 carbon atoms, or - a 7- to 10- or 12-membered bicyclic spiroheterocyclic ring comprising a nitrogen atom and, optionally,one to three additional heteroatoms selected from among a nitrogen atom, an oxygen atom, and a sulfur atom, and comprising 5 to 8 carbon atoms, wherein said monocyclic heterocycloalkyl ring, bicyclic heterocycloalkyl ring, and bicyclic spiroheterocyclic ring are unsubstituted or substituted by one to two substituents independently selected from among a (C1-C4)alkyl group, an NH2 group, a mono(C1-C4)alkylamino group, a di(C1-C4)alkylamino group, an NH2-(C1-C4)alkyl group, a mono(C1-C4)alkylamino-(C1-C4)alkyl group, a di(C1-C4)alkylamino-(C1-C4)alkyl group, an NH2-(C3) group. Petition 870250081269, dated 10 / 09 / 2025, pp. 740 / 792 6 / 48 C6)cycloalkyl, a (C2-C5)acylamino-(C1-C4)alkyl group, a (C2-C5)acylamino group, an (C2-C5)acyl group, a hydroxy-(C1-C4)alkyl group, a SH-(C1-C4)alkyl group; a CN-(C1-C4)alkyl group, a (C1C4)alkoxy-(C1-C4)alkyl group, a hydroxyl group, an oxo group, a (C3-C6)cycloalkyl group,a halogen atom, a halo(C1-C4)alkyl group, a cyano group, an NH2-C(=O) group, a mono(C1-C4)alkylamino-C(=O) group, a di(C1-C4)alkylamino-C(=O) group, an NH2C(=O)-(C1-C4)alkyl group, a mono(C1-C4)alkylamino-C(=O)-(C1C4)alkyl group or a di(C1-C4)alkylamino-C(=O)-(C1-C4)alkyl group, in particular, R4 and R5 form together with the nitrogen atom to which they are attached: - an unsubstituted azepanyl ring or a ring substituted by an OH-CH2- group; - an unsubstituted morpholino ring or one substituted by one or two substituents independently selected from among a methyl group, a CH2F group, an NH2-CH2 group, an N(CH3)2-CH2 group, a CH3-NH-(CH2)2 group, an SH-CH2- group, a CN-CH2 group, an OH-CH2 group, an OH-CD2 group, an OH-(CH2)2 group, an OHC(CH3)2 group, a CH3-CH(OH) group, a CH3-C(=O)-NH-CH2 group, a CH3-C(=O)-NH-CH2-CH2- group, a CH(CH3)2-C(=O)-NH-CH2 group, an NH2-C(=O) group, an NH(CH3)-C(=O) group, an N(CH3)2C(=O) group, an NH2-cyclopropyl group,a group NH2-C(=O)-CH2, a group NH(CH3)-C(=O)-CH2, a group N(CH3)2-C(=O)-CH2, a group CH3CH2-C(=O), an oxo group and a group CH3-O-CH2, - a thiomorpholino ring unsubstituted or substituted by one or two oxo groups; - a piperidinyl ring unsubstituted or substituted by one or two substituents independently selected from an NH2 group, an NH2-CH2 group, an NH(CH2CH3) group, an N(CH3)2 group, an NH2-cyclopropyl group, an N(CH3)2-CH2 group, an OH-CH2 group, a Petition 870250081269, dated 10 / 09 / 2025, page. 741 / 792 7 / 48 CH3-C(=O)-NH-CH2 group, a cyano group, a hydroxyl group, an oxo group and a fluorine atom, - an unsubstituted pyrrolidinyl ring or substituted by one or two substituents independently selected from an NH2 group, an NH2-CH2 group, an N(CH3)2-CH2 group, an OH-CH2 group, a CH3-O-CH2 group, a hydroxyl group and an oxo group, - an unsubstituted isoxazolidinyl ring or substituted by a hydroxyl group,- an unsubstituted piperazinyl ring or a ring substituted by one or two substituents independently selected from a methyl group, an oxo group, and an OH-CH2 group; - a hexahydropyrimidinyl ring substituted by an oxo group; - an unsubstituted azetidinyl ring or a ring substituted with an OH-CH2- group, - a tetrahydroquinolinyl ring or a dihydroquinolinyl ring, such as a 3,4-dihydro-2H-quinolinyl ring, unsubstituted or substituted with a hydroxyl group - a hexahydropyrido-oxazinyl ring, such as a hexahydro-2H-pyrido[3,4-b][1,4]oxazinyl ring, for example, a 3,4a,5,7,8,8ahexahydro-2H-pyrido[3,4-b][1,4]oxazinyl group, or a hexahydro-2H-pyrido[4,3-b][1,4]oxazin-4-yl ring, for example, a ring 3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazinyl, unsubstituted or substituted with a cyclobutyl group, a methyl group, an ethyl group, a 2,2,2-trifluoroethyl group, a 2-fluoroethyl group, a 3-fluoropropyl group,an isopropyl group or an acetyl group; - a hexahydropyran-oxazinyl ring, such as a hexahydro-2H-pyran[3,4-b][1,4]oxazinyl ring, for example, a 3,4a,5,7,8,8a-hexahydro-2H-pyran[3,4-b][1,4]oxazinyl group, or such as a hexahydro-2H-pyran[4,3-b][1,4]oxazinyl ring, for example, an unsubstituted 3,4a,5,7,8,8a-hexahydro-2H-pyran[4,3-b][1,4]oxazinyl ring; - a dihydropyrido-oxazinyl ring, such as dihydropyrido[3,4-b][1,4]oxazinyl ring or dihydropyrido[4,3-b][1,4]oxazinyl ring, for example 2,3-dihydropyrido[3,4-b][1,4]oxazinyl ring or ring 2,3-dihydropyrido[4,3-b][1,4]oxazinyl, unsubstituted; - a dihydropyrazolo-oxazinyl ring, such as the dihydro2H-pyrazolo[4,3-b][1,4]oxazinyl ring, for example, 5,6-dihydro-2H-pyrazolo[4,3-b][1,4]oxazinyl ring, unsubstituted; - a dihydrobenzoxazinyl ring, such as the dihydro-1,4-benzoxazinyl ring, for example, 2,3-dihydro-1,4-benzoxazinyl substituted with a hydroxyl group; - a tetrahydronaphthyridinyl ring or a dihydronaphthyridinyl ring, such as a 3,4-dihydro-2H-1,6-naphthyridinyl ring substituted with a hydroxyl group; - a hexahydronaphthyridinyl ring, such as a hexahydro2H-1,7-naphthyridinyl ring, for example, a 3,4,4a,5,6,8A-hexahydro-2H1,7-naphthyridinyl ring substituted with a methyl group and an oxo group; - an octahydronaphthyridinyl ring, such as the octahydro-1,7-naphthyridinyl ring or the octahydro-1,5-naphthyridinyl ring, for example, a 2,3,4,4a,5,6,7,8a-octahydro-1,7-naphthyridinyl ring, a 2,3,4,4a,5,6,8,8a-octahydro-1,7-naphthyridinyl ring, or a 2,3,4,4a,6,7,8,8a-octahydro-1,5-naphthyridinyl ring, substituted with an oxo group, a methyl group, or an acetyl group; - an octahydropyrrolopyridinyl ring or a hexahydropyrrolopyridinyl ring, such as the hexahydro-1H-pyrrolo[3,4-c]pyridinyl ring, octahydropyrrolo[2,3-c]pyridinyl ring or hexahydro-2H-pyrrolo[2,3-c]pyridinyl, for example, 2,3,3a,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridinyl ring, 2,3,3a,4,5,6,7,7a-octahydropyrrolo[2,3-c]pyridinyl ring or 3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridinyl ring, unsubstituted or Petition 870250081269, dated 10 / 09 / 2025, p. 743 / 792 9 / 48 substituted by a methyl group, an ethyl group, an acetyl group, an isopropyl group or an oxo group; - an octahydropyrrolo-oxazinyl ring or a hexahydropyrrolo-oxazinyl ring, such as the hexahydro-2H-pyrrolo[3,4-b][1,4]oxazinyl ring, for example, 2,3,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazinyl ring, 3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazinyl ring or 3,4a,5,6,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazinyl ring, unsubstituted or substituted by a methyl group, an ethyl group or an acetyl group; - a hexahydrocyclopentaoxazinyl ring, such as 3,4a,5,6,7,7a-hexahydro-2H-cyclopenta[b][1,4]oxazinyl substituted with a hydroxyl group; - an octahydropyrido-oxazinyl ring, such as the octahydropyrido[4,3-b][1,4]oxazinyl ring, for example, the unsubstituted 2,3,4a,5,6,7,8,8a-octahydropyrido[4,3-b][1,4]oxazinyl ring; - an indolinyl ring substituted with a hydroxyl group or a -CH2OH group; - a hexahydropyrrolopyrrolyl ring, such as a hexahydropyrrolo[3,4-b]pyrrolyl ring, a hexahydro-1H-pyrrolo[3,2-b]pyrrolyl ring or a hexahydro-2H-pyrrolo[3,4-b]pyrrolyl ring, for example, a 2,3,3a,4,6,6a-hexahydropyrrolo[3,4-b]pyrrolyl ring, a 2,3,3a,5,6,6a-hexahydro-1H-pyrrolo[3,2-b]pyrrolyl ring, or a 3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,4b]pyrrolyl ring that is unsubstituted or substituted with a methyl group, an ethyl group or an acetyl group; - a hexahydrofuropyrroyl ring, such as the hexahydrofuro[3,4-c]pyrrolyl ring, for example, the unsubstituted 1,3,3a,4,6,6a-hexahydrofuro[3,4c]pyrrolyl ring; - an azabicyclooctanyl ring, such as the 6-azabicyclo[3,2,1]octanyl substituted with a hydroxyl group; Petition 870250081269, dated 10 / 09 / 2025, p. 744 / 792 10 / 48 - a diazabicyclononanyl ring, such as a 3,6-diazabicyclo[3,2,2]nonanyl ring substituted with a methyl group - an oxa-azabicyclo-octanyl ring, such as an unsubstituted 3-oxa-8-azabicyclo[3,2,1]octanyl ring; - an azaspironanyl ring, such as an unsubstituted azaspiro[3,5]nonanyl ring, or substituted with a substituent selected from an NH2 group, a CH3-C(=O)-NH- group and a hydroxyl group; - an azaspiro-octanyl ring, such as an unsubstituted azas-piro[3,4]octanyl ring, or substituted with a hydroxyl group; - an azaspiro-heptanyl ring, such as an unsubstituted or hydroxyl-substituted azas-pyro[3,3]heptanyl ring; - a diazaspirodecanyl ring, such as a methyl-substituted 1,9-diazaspiro[4,5]decanyl ring; - a diazaspirononanyl ring, such as a non-anyl diazaspiro[3,5]nonanyl ring,not substituted or substituted by a methyl group; - a diazaspiro-heptanyl ring, such as a diazaspiro[3,3]heptanyl ring, not substituted or substituted by a methyl group; - an oxadiazaspironanyl ring, such as an 8-oxa-2,5-diazaspiro[3,5]nonanil ring substituted by a methyl group; - an oxadiazaspirodecanyl ring, such as a 2-oxa-6,9-diazaspiro[4,5]decanyl ring, a 9-oxa-2,6-diazaspiro[4,5]decanyl ring or a 6-oxa-2,9-diazaspiro[4,5]decanyl ring not substituted or substituted by an ethyl group or a methyl group; - an oxadiazaspiroundecanyl ring, such as a 4-oxa-1,8-diazaspiro[5,5]undecanyl ring substituted by a methyl group; - a dioxadiazaspirododecanyl ring, such as a 1,11dioxa-4,8-diazaspirododecanyl ring substituted with an ethyl group; - an oxa-azaspironanyl ring, such as an oxa-azaspirononanyl ring; and Petition 870250081269, dated 10 / 09 / 2025, p. 745 / 792 11 / 48 - an oxa-azaspiroheptanyl ring, such as an oxaazaspirononanyl ring;3]heptanil.
9. Compound of formula (I) or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 8, wherein said compound is characterized in that it is chosen from: (1) 1-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]piperi-din-4-ol; (2) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]piperidine-4-carbonitrile; (3) 7-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-7-azas-pyro[3,5]nonan-2-ol; (4) 3,5-dimethyl-2-[6-[rac-(4aS,8aR)-6-cyclobutyl-3,4a,5,7,8,8a-hexahydro-2H-pyrido[3,4-b][1,4]oxazin-1-yl]pyridazin-3yl]phenol; (5) 2-[6-[(3R)-3-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (6) 2-[6-[(3S)-3-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (7) 2-[6-(2,7-diazaspiro[3,5]nonan-7-yl)pyridazin-3-yl]-3,5-dimethyl-phenol; 2,2,2-trifluoroacetic acid; (8) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]- 3,5-dimethyl-phenol; (9) 2-[6-[(2R)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]- 3,5-dimethyl-phenol; (10) 2-[6-[(4aR,8aS)-6-cyclobutyl-3,4a,5,7,8,8a-hexa-hydro-2H-pyrido[4,3-b][1,4] oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol Enantiomer 1; Petition 870250081269, of 10 / 09 / 2025, p. 746 / 792 12 / 48 (11) 2-[6-[(4aS,8aR)-6-cyclobutyl-3,4a,5,7,8,8a-hexa-hydro-2H-pyrido[4,3-b][1,4] oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; formic acid Enantiomer 2; (12) 2-[6-[(4aR,8aS)-6-cyclobutyl-3,4a,5,7,8,8a-hexa-hydro-2H-pyrido[4,3-b][1,4] oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)enophenol 1; (13) 2-[6-[(4aS,8aR)-6-cyclobutyl-3,4a,5,7,8,8a-hexa-hydro-2H-pyrido[4,3-b][1,4] oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)enzyme 2; (14) 2-[6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]pyridazin-3-yl]- 3-methyl-5-(trifluoromethyl)phenol; (15) 2-[6-[(2S)-2-(methoxymethyl)pyrrolidin-1 -yl]pyridazin-3-yl]- 3-methyl-5-(trifluoromethyl)phenol; (16) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]- 3-methyl-5-(trifluoromethyl)phenol; (17) 2-[6-[3-(1-aminocyclopropyl)-1-piperidyl]pyridazin-3-yl]-3,5-dichloro-phenol; (18) 2-[6-[(3S)-3-(aminomethyl)-1 -piperidyl]pyridazin-3-yl]-3,5-dichloro-phenol; (19) 2-[6-[4-(aminomethyl)-1-piperidyl]pyridazin-3-yl]-3,5-di- chloro-phenol; (20) 2-[6-[(3S)-3-(hydroxymethyl)pyrrolidin-1-yl]pyridazin-3-yl]- 3-methyl-5-(trifluoromethyl)phenol; (21) 3,5-dichloro-2-[6-[(2S)-2-(hidroximethyl)morpholin-4-yl]pyridazin-3-yl]phenol; (22) 2-[6-[(3R)-3-(aminomethyl)-1 -piperidyl]pyridazin-3-yl]- 3,5-dichloro-phenol; (23) 2-[6-[(3S)-3-(aminomethyl)pyrrolidin-1 -yl]pyridazin-3-yl]-3,5-dichloro-phenol; Petition 870250081269, 10 / 09 / 2025, pág. 747 / 792 13 / 48 (24) 2-[6-[2-[(dimethylamino)methyl]morpholin-4-yl]pyridazin-3yl]-3-methyl-5-(trifluoromethyl)phenol; (25) 2-[6-[(3R)-3-(aminomethyl)pyrrolidin-1 -yl]pyridazin-3-yl]- 3,5- dichloro-phenol; (26) 2-[6-[2-(1-hydroxi-1-methyl-ethyl)morpholine-4-yl]pyridazin-3yl]-3-methyl-5-(trifluoromethyl)phenol (27) 2-[6-[(2R)-2-[(dimethylamino)methyl]morpholin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (28) 2-[6-[(3S)-3-(hidroxymethyl)-1-piperidyl]pyridazin-3-yl]-3methyl-5-(trifluoromethyl)phenol; (29) 3-methyl-2-[6-(4-methylpiperazin-1-yl)pyridazin-3-yl]-5-(trifluoromethyl)phenol; (30) 2-[6-[3-(hydroxymethyl)azetidin-1 -yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (31) 2-[6-[(3R)-3-amino-1-piperidyl]pyridazin-3-yl]-3,5-dimethyl-phenol; formic acid; (32) 2-[6-(2-amino-7-azaspiro[3,5]nonan-7-yl)pyridazin-3- il]-3,5-dichloro-phenol; (33) 3,5-dichloro-2-[6-[(2R)-2-(methoxymethyl)morpholin-4-yl]pyri- dazin-3-yl]phenol; (34) 3,5-dichloro-2-[6-[(3S)-3-(hydroxymethyl)-1 -piperidyl]pyri- dazin-3-yl]phenol; (35) 3,5-dichloro-2-[6-[(2S)-2-(methoxymethyl)morpholin-4-yl]pyri- dazin-3-yl]phenol; (36) 3,5-dichloro-2-[6-[(3R)-3-(hydroxymethyl)-1 -piperidyl]pyri- dazin-3-yl]phenol; (37) 7-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3-yl]-7-azas- pyro[3,5]nonan-2-ol; (38) 3,5-dichloro-2-(6-morpholinopyridazin-3-yl)phenol; Petition 870250081269, dated 10 / 09 / 2025, p. 748 / 792 14 / 48 (39) 3,5-dichloro-2-[6-[(2S)-2-[(dimethylamino)methyl]morpholin- 4-yl]pyridazine-3-yl]phenol; (40) 3,5-dichloro-2-[6-[(3S)-3-[(dimethylamino)methyl]pyrroli- din-1 -yl]pyridazine-3-yl]phenol; (41) 3,5-dichloro-2-[6-[(3R)-3-[(dimethylamino)methyl]pyrroli- din-1 -yl]pyridazine-3-yl]phenol; (42) 6-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3-yl]-6-azas- pyro[3,4]octan-2-ol; (43) 3,5-dichloro-2-[6-[(2R)-2-[(dimethylamino)methyl]morpholin- 4-yl]pyridazine-3-yl]phenol; (44) 3-fluoro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyrida- zin-3-yl]phenol; (45) 3-fluoro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyrida- zin-3-yl]-5-methyl-phenol; (46) 2-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3-yl]-2-azas- pyro[3,3]heptan-6-ol; (47) N-[7-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3-yl]-7- azaspiro[3,5]nonan-2-yl]acetamide; (48) 3-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyrida- zin-3-yl]phenol; (49) 3,5-dichloro-2-[6-(4,4-difluoro-1 -piperidyl)pyridazine-3- il]phenol; (50) 3,5-dichloro-2-[6-[(3R)-3-[(dimethylamino)methyl]-1 -pipe- ridyl]pyridazine-3-yl]phenol; (51) 3,5-dichloro-2-[6-[(3S)-3-[(dimethylamino)methyl]-1 -piperi- dil]pyridazine-3-yl]phenol; (52) 2-[6-[2-(1-hydroxy-1-methyl-ethyl)morpholin-4-yl]pyridazine-3- il]-3-methyl-5-(trifluoromethyl)phenol Enantiomer 1; (53) 2-[6-[-2-(1-hydroxy-1-methyl-ethyl)morpholin-4-yl]pyridazine- 3-yl]-3-methyl-5-(trifluoromethyl)phenol Enantiomer 2; Petition 870250081269, dated 10 / 09 / 2025, p. 749 / 792 15 / 48 (54) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]3-(trifluoromethyl)phenol; (55) 3,5-dichloro-2-[6-(2-methyl-2,7-diazaspiro[3,5]nonan-7- il)pyridazine-3-yl]phenol; (56) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]- 3-methyl-phenol; (57) N-[[(3R)-1-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3- il]-3-piperidyl] methyl]acetamide; (58) N-[[(3S)-1-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3- il]-3-piperidyl]methyl]acetamide; (59) 2-[6-[-2-[(dimethylamino)methyl]morpholin-4-yl]pyridazine-3- il]-3-methyl-5-(trifluoromethyl)phenol Enantiomer 1; (60) 2-[6-[-2-[(dimethylamino)methyl]morpholin-4-yl]pyridazine-3- il]-3-methyl-5-(trifluoromethyl)phenol Enantiomer 2; (61) 1 -[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazine- 3-yl]pyrrolidin-2-one; (62) (4S)-4-hydroxy-1-[6-[2-hydroxy-6-methyl-4-(trifluorome- til)phenyl]pyridazine-3-yl]pyrrolidin-2-one; (63) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyrida- zin-3-yl]-3-methyl-phenol; (64) 3,5-dichloro-2-[6-(2-oxa-6-azaspiro[3,3]heptan-6-yl)pyridazin-3-yl]phenol; (65) 2-[6-[(3R)-3-(hydroxymethyl)pyrrolidin-1-yl]pyridazine-3-yl]- 3,5-dimethyl-phenol; (66) 3,5-dichloro-2-[6-(2-oxa-7-azaspiro[3,5]nonan-7-yl)pyri- dazin-3-yl]phenol; (67) (3S)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3-yl]pi- peridin-3-ol; (68) 2-[6-[(3S)-3-(ethylamino)-1 -piperidyl]pyridazine-3-yl]-3,5- dimethyl-phenol; Petition 870250081269, dated 10 / 09 / 2025, p. 750 / 792 16 / 48 (69) 2-[6-[(3S)-3-amino-1-piperidil]piridazin-3-il]-3,5-dime-til-phenol; (70) (3R)-1-[6-(2-hidróxi-4,6-dimetil-fenil)piridazin-3-il]pir- rolidin-3-ol; (71) (3S)-1-[6-(2-hidróxi-4,6-dimetil-fenil)piridazin-3-il]pir-rolidin-3-ol; (72) 2-[4-etil-6-[(2S)-2-(hydrroximetil)morfolin-4-il]piridazin- 3-il]-5-metil-phenol; (73) 5-chloro-2-[4-etil-6-[(2S)-2-(hidroximetil)morfolin-4-il]piridazin-3-il]phenol; (74) 2-[6-[(2S)-2-(hidroximetil)morfolin-4-il]-4-isopropil-pi-ridazin-3-il]-5-metil-phenol; (75) 5-chloro-2-[6-[(2S)-2-(hydrroximetil)morfolin-4-il]-4-iso-propil-piridazin-3-il]phenol; (76) 2-[6-[(2S)-2-(hydrroximetil)morfolin-4-il]-4-metil-pirida-zin-3-il]-5-metil-phenol; (77) 2-[4-[(2S)-2-(hidroximetil)morfolin-4-il]-6,7-di-hidro- 5H-ciclopenta[d]piridazin-1-il]-5-methyl-fenol; (78) 5-chloro-2-[4-[(2S)-2-(hidroximetil)morfolin-4-il]-6,7-di-hidro-5H-ciclopenta[d]piridazin-1-il]phenol; (79) 2-[6-[(3S)-3-(hydroxymethyl)pyrrolidin-1-yl]pyridazine-3-yl]- 3,5-dimethyl-phenol; (80) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4,5-dimethyl-pyridazin-3-yl]-5-methyl-phenol; (81) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4,5-di- methyl-pyridazine-3-yl]phenol; (82) 2-[6-[(3S)-3-(methoxymethyl)pyrrolidin-1-yl]pyridazine-3-yl]- 3,5-dimethyl-phenol; (83) 2-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-2-azas- pyro[3,5]nonan-7-ol; Petition 870250081269, dated 10 / 09 / 2025, p. 751 / 792 17 / 48 (84) 2-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-2-azas- pyro[3,4]octan-6-ol; (85) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-me- til-pyridazine-3-yl]phenol; (86) (4S)-4-hydroxy-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyride- zin-3-yl]pyrrolidin-2-one; (87) 2-[6-[(2R)-2-(aminomethyl)morpholin-4-yl]pyridazine-3-yl]- 3,5-dimethyl-phenol; 2,2,2-trifluoroacetic acid; (88) 2-[6-[(3R)-3-(methoxymethyl)pyrrolidin-1-yl]pyridazine-3-yl]- 3,5-dimethyl-phenol; (89) 2-[6-[(2R)-2-(aminomethyl)morpholin-4-yl]pyridazine-3-yl]- 3,5-dimethyl-phenol; 2,2,2-trifluoroacetic acid; (90) 6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-3-(2-hydroxy-4- methyl-phenyl)pyridazine-4-carbonitrile; (91) 3,5-dimethyl-2-[6-(1-methyl-1,6-diazaspiro[3,3]heptan-6- il)pyridazine-3-yl]phenol; (92) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]- 5-methyl-phenol; (93) 5-fluoro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-me- til-pyridazine-3-yl]phenol; (94) 2-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3-yl]-2-azas- pyro[3,4]octan-6-ol Enantiomer 1; (95) 2-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3-yl]-2-azas- pyro[3,4]octan-6-ol Enantiomer 2; (96) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]- 5-methoxy-3-methyl-phenol; (97) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyrida- zin-3-yl]-5-(trifluoromethyl)phenol; (98) 2-[6-[2-[(1S)-1-hydroxyethyl]morpholin-4-yl]pyridazine-3-yl]- 3,5-dimethylphenol Diastereoisomer 2; Petition 870250081269, dated 10 / 09 / 2025, p. 752 / 792 18 / 48 (99) 2-[6-[2-[(1S)-1-hydroxyethyl]morpholin-4-yl]pyridazine-3-yl]3,5-dimethylphenol Diastereoisomer 1; (102) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]4-methyl-phenol; (103) 3-(4-chloro-2-hydroxy-phenyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-4-carbonitrile; (105) N-[[(2S)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3- il]morpholin-2-yl]methyl]acetamide; (106) N-[[(2R)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3- il]morpholin-2-yl]methyl]acetamide; (107) 2-[6-[3-(hydroxymethyl)azepan-1 -yl]pyridazine-3-yl]-3,5-di- methyl-phenol; (108) 2-[6-[2-[(1R)-1-hydroxyethyl]morpholin-4-yl]pyridazine-3-yl]3,5-dimethyl-phenol Diastereoisomer 1; (109) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-5-methyl-pyridazine-3-yl]-3,5-dimethyl-phenol; (110) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-5-methyl-pyridazine-3-yl]-5-methyl-phenol; (111) 2-[6-[rac-(4aS,8aS)-3,4a,5,7,8,8a-hexa-hydro-2H-py- rano[3,4-b][1,4]oxazine-1-yl]pyridazine-3-yl]-3,5-dimethyl-phenol; (112) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazine-3-yl]-3,5-dimethyl-phenol; (113) (4R)-2-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3-yl]iso-xazolidin-4-ol (114) 2-[6-[1 -(hydroxymethyl)-6-azabicyclo[3,2,1]octan-6-yl]pyri- dazin-3-yl]-3,5-dimethyl-phenol; (115) 2-[6-[(2S)-2-(hydroxymethyl)azetidin-1 -yl]pyridazine-3-yl]3,5-dimethyl-phenol; (116) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazine-3-yl]-5-methoxy-phenol; Petition 870250081269, dated 10 / 09 / 2025, p. 753 / 792 19 / 48 (117) 3,5-dichloro-2-[6-[(2S)-2-(hydroxymethyl)azetidin-1-yl]pyri- dazin-3-yl]phenol; (118) 2-[6-[(2R)-2-(hydroxymethyl)azetidin-1 -yl]pyridazine-3-yl]3,5-dimethyl-phenol; (119) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazine-3-yl]-5-methoxy-3-methyl-phenol; (120) 3,5-dimethyl-2-[6-(3-oxa-8-azabicyclo[3,2,1]octan-8- il)pyridazin-3-yl]phenol; (121) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]3-methyl-5-(trifluoromethoxy)phenol; (122) 1 -[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3-yl]-3-(hi- droxymethyl)pyrrolidin-2-one; (123) 2-[6-[(3R)-3-(aminomethyl)morpholin-4-yl]pyridazine-3-yl]3,5-dimethyl-phenol; 2,2,2-trifluoroacetic acid; (124) 2-[6-[(3S)-3-(aminomethyl)morpholin-4-yl]pyridazine-3-yl]3,5-dimethyl-phenol; (125) 2-[6-[(4aR,7aR)-3,4,4a,5,7,7a-hexa-hydro-2H-pyrrolo[3,4-b][1,4]oxazine-6-yl]pyridazine-3-yl]-3,5-dimethylphenol; (126) 1 -[4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazine-3-yl]morpho- lin-2-yl]propan-1-one; (127) 5-chloro-2-[6-[(3S)-3-(hydroxymethyl)pyrrolidin-1-yl]pyridazine-3-yl]-3-methyl-phenol; (128) 2-[6-[(3S)-3-(dimethylamino)-1-piperidyl]pyridazine-3-yl]3,5-dimethyl-phenol; (129) N-[[(3R)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3- il]morpholin-3-yl]methyl]acetamide; (130) (4S)-1-[6-(4-chloro-2-hydroxy-6-methyl-phenyl)pyridazin-3yl]-4-hydroxy-pyrrolidin-2-one; (131) (4S)-4-amino-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyrida- zin-3-yl]pyrrolidin-2-one; Petition 870250081269, dated 10 / 09 / 2025, p. 754 / 792 20 / 48 (132) (4R)-4-hydroxy-1-[6-[2-hydroxy-6-methyl-4-(trifluorome- til)phenyl]pyridazine-3-yl]pyrrolidin-2-one; (133) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-5-methyl-pyridazine-3-yl]-3-methyl-phenol; (134) 5-(difluoromethyl)-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4yl]pyridazine-3-yl]-3-methyl-phenol; (135) 2-[6-[(2S)-2-(1-aminocyclopropyl)morpholin-4-yl]pyridazine-3-yl]-3,5-dimethyl-phenol; (136) 2-[6-[(2R)-2-(1-aminocyclopropyl)morpholin-4-yl]pyridazine-3-yl]-3,5-dimethyl-phenol; (137) (4R)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3-yl]-4- (hydroxymethyl)pyrrolidine-2-one; (138) (4S)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3-yl]-4- (hydroxymethyl)pyrrolidin-2-one; (139) (3R)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3-yl]-3- (hydroxymethyl)pyrrolidin-2-one; (140) (3S)-1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3-yl]-3- (hydroxymethyl)pyrrolidin-2-one; (141) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]3,6-dimethylphenol; (142) 2-[(2R)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazine-3- il]morpholin-2-yl]-N-methylacetamide; (143) 2-[(2S)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazine-3- il]morpholin-2-yl]-N-methylacetamide; (144) 2-[4-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4yl]pyridazine-3-yl]-5-methyl-phenol; (145) 5-chloro-2-[4-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]phenol; (146) 2-[(2R)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazine-3- il]morpholin-2-yl]acetamide; Petition 870250081269, dated 10 / 09 / 2025, p. 755 / 792 21 / 48 (147) 2-[(2S)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazine-3- il]morpholin-2-yl]acetamide; (148) 2-[6-[(3R)-3-(dimethylamino)-1-piperidyl]pyridazine-3-yl]3,5-dimethyl-phenol; (149) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazine-3-yl]-3-methyl-phenol; (150) 2-[(2R)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazine-3- il]morpholin-2-yl]-N,N-dimethylacetamide; (151) 2-[(2S)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazine-3- il]morpholin-2-yl]-N,N-dimethylacetamide; (152) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]4,6-dimethylphenol; (153) 3-(difluoromethyl)-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4- il]pyridazine-3-yl]-5-methyl-phenol; (154) 3,5-dimethyl-2-[6-[rac-(4aR,8aS)-3,4a,5,7,8,8a-hexa- hydro-2H-pyrano[3,4-b][1,4]oxazine-1-yl]pyridazine-3-yl]phenol; (155) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-(trifluoromethyl)pyridazine-3-yl]-5-methyl-phenol; (156) 1 -[(2R)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazine-3- il]morpholin-2-yl]propan-1-one; (157) 1 -[(2S)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazine-3- il]morpholin-2-yl]propan-1-one; (158) 6-(2-hydroxy-4,6-dimethyl-phenyl)-3-[(2S)-2-(hydroxyme- til)morpholin-4-yl]pyridazine-4-carbonitrile; (159) 3-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-6-[2-hydroxy-6methyl-4-(trifluoromethyl)phenyl]pyridazine-4-carbonitrile; (160) 5-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-(trifluoromethyl)pyridazine-3-yl]phenol; (161) 3,5-dichloro-2-[6-[2-(fluoromethyl)morpholin-4-yl]pyridazine- 3-yl]phenol; Petition 870250081269, dated 10 / 09 / 2025, p. 756 / 792 22 / 48 (162) 4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-2,3-di- hydro-1,4-benzoxazin-6-ol; (163) 6-(4-chloro-2-hydroxy-6-methyl-phenyl)-3-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-4-carbonitrile; (164) N-[[(3S)-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazine-3-yl]-3-piperidyl]methyl]acetamide; (165) 2-[6-[(2S)-2-[dideuterium(hydroxy)methyl]morpholin-4-yl]pyridazine-3-yl]-3,5-dimethylphenol; (166) (2S)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazine-3-yl]-N- methylmorpholine-2-carboxamide; (167) N-[[(3R)-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazine-3-yl]-3-piperidyl]methyl]acetamide; (168) 2-[6-[(4aR,7aR)-4-ethyl-2,3,4a,5,7,7a-hexa-hydropyrrolo[3,4-b][1,4]oxazine-6-yl]pyridazine-3-yl]-3,5-dimethylphenol; (169) 5-chloro-2-[6-[(2S)-2-[dideuterium(hydroxy)methyl]morpholin4-yl]pyridazine-3-yl]-3-methylphenol; (170) 2-[5-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4yl]pyridazine-3-yl]-3,5-dimethyl-phenol; (171) 5-chloro-2-[5-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]-3-methyl-phenol; (172) 3-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]-5-methyl-phenol; (173) 2-[6-[(2R,6S)-2,6-bis(hydroxymethyl)morpholin-4-yl]pyrida- zin-3-yl]-3,5-dimethyl-phenol; (174) 2-[6-[2-(fluoromethyl)morpholin-4-yl]pyridazine-3-yl]-3,5-dimethyl-phenol; (175) 6-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3-yl]-6-azas- pyro[3,5]nonan-2-ol Isomer 1; (176) 6-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3-yl]-6-azas- pyro[3,5]nonan-2-ol Isomer 2; Petition 870250081269, dated 10 / 09 / 2025, p. 757 / 792 23 / 48 (177) 3-chloro-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-4-methyl-pyridazine-3-yl]-5-methyl-phenol; (178) 2-[6-[(2R,6S)-2,6-bis(hydroxymethyl)morpholin-4-yl]pyrida- zin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (179) (4S)-2-[6-(2-hydroxi-4,6-dimethyl-phenyl)pyridazin-3-yl]iso-xazolidin-4-ol (180) 2-[6-[2-[(1R)-1-hidroxyethyl]morpholin-4-yl]pyridazin-3-yl]3,5-dimethylphenol Diastereoisomer 2; (181) (2S)-4-[6-(2-hydroxi-4,6-dimethylphenyl)pyridazin-3-yl]morpholine-2-carboxamida; (182) (2R)-4-[6-(2-hydroxi-4,6-dimethylphenyl)pyridazin-3-yl]-N-methylmorpholine-2-carboxamida; (183) (2R)-4-[6-(2-hydroxi-4,6-dimethylphenyl)pyridazin-3-yl]morpholine-2-carboxamida; (184) (2R)-4-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]- N,N-dimethylmorpholine-2-carboxamide; (185) 2-[6-[(4aS,7aS)-3,4,4a,5,7,7a-hexa-hidro-2H-pyr-rolo[3,4-b][1,4]oxazin-6-yl]pyridazin-3-yl]-3,5-dimethylphenol; (186) 2-[4-(hidroxymethyl)-6-[(2S)-2-(hidroxymethyl)morpholin-4yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (187) 2-[5-(hidroxymethyl)-6-[(2S)-2-(hidroxymethyl)morpholin-4yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (188) 5-chloro-2-[4-(hydroxymethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]-3-methyl-phenol; (189) 5-chloro-2-[5-(hydroxymethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]-3-methyl-phenol; (190) 2-[6-[rac-(4aR,7aR)-3,4a,5,6,7,7a-hexa-hydro-2H-pyrrolo[3,4-b][1,4]oxazine-4-yl]pyridazine-3-yl]-3,5-dimethylphenol; (191) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]3,4-dimethylphenol; Petition 870250081269, dated 10 / 09 / 2025, p. 758 / 792 24 / 48 (192) 2-[6-[(2S)-2-[dideuterium(hydroxy)methyl]morpholin-4-yl]pyridazine-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (193) 4-[6-(4-chloro-2-hydroxy-6-methyl-phenyl)pyridazin-3-yl]-2,3di-hydro-1,4-benzoxazin-7-ol; (194) 2-[5-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4yl]pyridazine-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (195) 2-[6-[rac-(4aR,8aS)-2,3,4a,5,6,7,8,8a-octa-hydropyrido[4,3-b][1,4]oxazine-4-yl]pyridazine-3-yl]-3,5-dimethyl-phenol; (196) 3,5-dimethyl-2-[6-(2-oxa-6,9-diazaspiro[4,5]decan-9-yl)pyridazin-3-yl]phenol; (197) 2-[6-[rac-(4aR,8aS)-2,3,4a,5,6,7,8,8a-octa-hydropyrido[4,3-b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (198) 2-[6-[(2S,6S)-2,6-bis(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (199) 2-[6-[(2S,6S)-2,6-bis(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (200) 2-[6-[(2R,6R)-2,6-bis(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (201) 2-[6-[(2R,6R)-2,6-bis(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (203) 3,5-dichloro-2-(6-thiomorpholinopyridazin-3-yl)phenol; (204) 5-cyclopropyl-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4yl]pyridazin-3-yl]-3-methyl-phenol; (206) 2-[6-[(3aS,6aR)-1,3,3a,4,6,6a-hexa-hydrofuro[3,4-c]pyrrol-5-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (207) 2-[6-[(3aR,6aR)-1,3,3a,4,6,6a-hexa-hidrofuro[3,4-c]pirrol-5-il]piridazin-3-il]-3,5-dimetil-fenol; (208) 2-[6-(8-etil-1,11 -dioxa-4,8-diazaspiro[5,6]dodecan-4- il)piridazin-3-il]-3,5-dimetilfenol; Petition: 870250081269, on September 10, 2025, page. 759 / 792 25 / 48 (209) 2-[6-[rac-(4aR,8aS)-6-etil-3,4a,5,7,8,8a-hexa-hidro- 2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3,5-dimetil-fenol; (210) 2-[6-[rac-(4aR,8aS)-6-etil-3,4a,5,7,8,8a-hexa-hydro- 2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3-metil-5-(trifluorometil)phenol; (211)N-[[(3S)-1-[6-(4-chloro-2-hidróxi-6-metil-fenil)piridazin3-il]-3-piperidil]metil]acetamida; (212) N-[[(3R)-1-[6-(4-chloro-2-hidróxi-6-metil-fenil)piridazin3-il]-3-piperidil]metil]acetamida; (213) 1 -[rac-(4aR,8aS)-4-[6-(2-hidróxi-4,6-dimetil-fenil)piri- dazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6-il]etanona; (214) 1-[rac-(4aR,8aS)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazine-3-yl]-3,4a,5,7,8,8a-hexa-hydro-2H-pyrido[4,3b-oxa][1,4][1,4] (215) 2-[6-(2,3-di-hydropyrido[3,4-b][1,4]oxazin-1 -yl)pyrida- zin-3-yl]-3,5-dimethyl-phenol; (216) N-[[(2R)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazine-3-yl]morpholin-2-yl]methyl]acetamide; (217) 1 -[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-3,4-di- hydro-2H-quinolin-7-ol; (219) 2-[6-[(2S)-2-(fluoromethyl)morpholin-4-yl]pyridazine-3-yl]3,5-dimethyl-phenol; (220) 2-[6-[(2R)-2-(fluoromethyl)morpholin-4-yl]pyridazine-3-yl]3,5-dimethyl-phenol; (221) 2-[6-[rac-(4aR,8aS)-2,3,4a,5,6,7,8,8a-octa-hydropyrido[4,3-b][1,4]oxazine-4-yl]pyridazine-3-yl]-5-chloro-3-methyl-phenol; (222) 1 -[rac-(4aR,8aS)-4-[6-(4-chloro-2-hidróxi-6-metil-fe- nil)piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6il]etanona; Petition: 870250081269, on September 10, 2025, page. 760 / 792 26 / 48 (223) 2-[6-[rac-(4aR,8aS)-6-etil-3,4a,5,7,8,8a-hexa-hidro- 2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-5-chloro-3-methyl-fenol; (224) 2-[6-[rac-(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexa-hi- dro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-5-chloro-3-methyl-fenol; (225) 2-[6-[rac-(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexa-hi- dro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3,5-dimetil-fenol; (226) 2-[6-[rac-(4aR,8aS)-6-metil-3,4a,5,7,8,8a-hexa-hi- dro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3-metil-5-(trifluorometil)phenol; (227) 2-[6-(6-etil-2-oxa-6,9-diazaspiro[4,5]decan-9-il)piri-dazin-3-il]-3,5-dimetilfenol; (228) 1 -[rac-(3aS,6aS)-1-[6-[2-hydroxy-6-methyl-4-(trifluoro- methyl)phenyl]pyridazine-3-yl]-2,3,3a,4,6,6a-hexa-hydropyrrole[3,4-b]pyrrolenone; (229) 2-[6-[rac-(3aS,6aS)-3,3a,4,5,6,6a-hexa-hydro-2H-pyrrolo[3,4-b]pyrrol-1-yl]pyridazine-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (230) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-3,4-di- hydro-2H-quinolin-6-ol; (231) 1 -[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-3,4-di- hydro-2H-quinolin-8-ol; (232) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-3,4-di- hydro-2H-quinolin-5-ol; (233) 2-[6-[(2R)-2-(2-hydroxyethyl)morpholin-4-yl]pyridazine-3-yl]3,5-dimethyl-phenol; (234) 2-[6-[(2S)-2-(2-hydroxyethyl)morpholin-4-yl]pyridazine-3-yl]3,5-dimethyl-phenol; (235) 1 -[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-5-(hi- droxymethyl) piperidin-2-one; (236) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]indolin- 5-ol; Petition 870250081269, dated 10 / 09 / 2025, p. 761 / 792 27 / 48 (237) 3,5-dichloro-2-[6-[(2R)-2-(fluoromethyl)morpholin-4-yl]pyri- dazin-3-yl]phenol; (238) 3,5-dichloro-2-[6-[(2S)-2-(fluoromethyl)morpholin-4-yl]pyri- dazin-3-yl]phenol; (239) 1-[6-(2,4-dichloro-6-hydroxy-phenyl)pyridazin-3-yl]hexa-hi- dropirimidin-2-ona; (240) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]indolin- 4-ol; (241) 2-[6-[4-(hydroxymethyl)indolin-1 -yl]pyridazine-3-yl]-3,5-di- methyl-phenol; (242) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazine-3-yl]-3,4-di- hydro-2H-1,6-naphthyridine-5-ol; (243) 2-[6-[rac-(3aS,6aS)-5-ethyl-2,3,3a,4,6,6a-hexa-hydro- pyrrolo[3,4-b]pyrrol-1-yl]pyridazine-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (245) 5-ethyl-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine- 3-yl]-3-methylphenol; (246) 3-ethyl-2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-5-methylphenol; (247) 2-[4-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol; (248) 2-[4-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (249) 5-chloro-2-[4-(difluoromethyl)-6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazin-3-yl]-3-methyl-phenol; (250) (4S)-4-amino-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3-yl]pyrrolidin-2-one; (251) 2-[6-[(4aR,8aS)-2,3,4a,5,6,7,8,8a-octa-hydropyrido[4,3-b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (252) 2-[6-[(4aS,8aR)-2,3,4a,5,6,7,8,8a-octa-hydropyrido[4,3-b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; Petition 870250081269, de 10 / 09 / 2025, pág. 762 / 792 28 / 48 (253) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]indolin-7-ol; (254) 1-[6-(2-hidróxi-4,6-dimetil-fenil)piridazin-3-il]indolin- 6-ol; (255) 2-[6-[(4aR,8aS)-6-etil-3,4a,5,7,8,8a-hexa-hydro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3-metil-5-(trifluorometil)phenol; (256) 2-[6-[(4aS,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (257) 1-[rac-(4aS,7aS)-4-[6-(2-hidróxi-4,6-dimetilfenil)piri- dazin-3-il]-2,3,4a,5,7,7a-hexa-hidropirrolo[3,4-b][1,4]oxazin-6-il]etanona; (258) 3-metil-2-[6-[(2R)-2-metilmorfolin-4-il]piridazin-3-il]-5(trifluorometil)phenol; (259) 3-metil-2-[6-[(2S)-2-metilmorfolin-4-il]piridazin-3-il]-5(trifluorometil)phenol; (260) 2-[6-[(4aR,8aS)-6-metil-3,4a,5,7,8,8a-hexa-hydro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3-metil-5-(trifluorometil)phenol; (261) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (262) 1 -[(4aR,8aS)-4-[6-[2-hidróxi-6-metil-4-(trifluorome til)fenil]piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6-il]etanona; (263) 1-[(4aS,8aR)-4-[6-[2-hidróxi-6-metil-4-(trifluorome- til)fenil]piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6-il]etanona; (264) rac-(3aS,7aR)-5-[6-[2-hidróxi-6-metil-4-(trifluorometil)fenil]piridazin-3-il]-2,3,3a,6,7,7a-hexa-hidro-1H-pirrolo[3,4-c]piridin-4ona, chloridrato; (265) 2-[6-[rac-(3aS,6aS)-5-metil-2,3,3a,4,6,6a-hexa-hi-dropirrolo[3,4-b]pirrol-1-il]piridazin-3-il]-3-metil-5-(trifluorometil)phenol; Petition: 870250081269, on September 10, 2025, page. 763 / 792 29 / 48 (266) 2-[6-[(2R)-2-(hydrroximetil)morfolin-4-il]piridazin-3-il]3-metil-5-(trifluorometil)phenol; (267) N-[[(2R)-4-[6-(4-chloro-2-hidróxi-6-metil-fenil)piridazin3-il]morfolin-2-il]metil]acetamida; (268) 2-[6-[(4aR,8aS)-6-metil-3,4a,5,7,8,8a-hexa-hydro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-(difluorometil)piridazin-3-il]-5-(trifluorometil)phenol; (269) rac-(3aS,7aS)-5-[6-[2-hidróxi-6-metil-4-(trifluorometil)fenil]piridazin-3-il]-2,3,3a,6,7,7a-hexa-hidro-1H-pirrolo[3,4-c]piridin-4ona, chloridrato; (270) 2-[6-[(3aR,6aR)-5-methyl-2,3,3a,4,6,6a-hexa-hidropirrolo[3,4-b]pirrol-1-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (271) 2-[6-[(3aS,6aS)-5-metil-2,3,3a,4,6,6a-hexa-hydropyr-rolo[3,4-b]pirrol-1-il]piridazin-3-il]-3-metil-5-(trifluorometil)phenol; (272) 2-[6-(3,4-di-hydro-2H-quinolin-1 -il)piridazin-3-il]-3,5- dimetil-phenol; (273) 3-(hidroximetil)-1-[6-[2-hidróxi-6-metil-4-(trifluorometil)fenil]piridazin-3-il]piperidin-2-ona; (274) 2-[6-[(2S)-2-(hydroxymethyl)morpholin-4-yl]pyridazine-3-yl]5-isopropyl-3-methyl-phenol; (275) N-[[(2S)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazine-3-yl]morpholin-2-yl]methyl]acetamide; (276) N-[[(2S)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazine-3-yl]morpholin-2-yl]methyl]-2-methylpropanamide; (277) N-[2-[(2R)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazine-3-yl]morpholin-2-yl]ethyl]acetamide; (278) N-[2-[(2S)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazine-3-yl]morpholin-2-yl]ethyl]acetamide; (279) N-[(2R)-4-[6-(4-chloro-2-hydroxy-6-methylphenyl)pyridazine3-yl]morpholin-2-yl]methyl]-2-methylpropanamide; and Petition 870250081269, dated 10 / 09 / 2025, p. 764 / 792 30 / 48 (280) N-[[(2S)-4-[6-(4-chloro-2-hydroxy-6-methylphenyl)pyridazine3-yl]morpholin-2-yl]methyl]acetamide; (283) 2-[6-[(2R)-2-(fluoromethyl)morpholin-4-yl]pyridazine-3-yl]-3methyl-5-(trifluoromethyl)phenol; (284) 2-[6-[(2S)-2-(fluoromethyl)morpholin-4-yl]pyridazin-3-yl]-3methyl-5-(trifluoromethyl)phenol; (285) N-[(2S)-4-[6-(4-chloro-2-hydroxy-6-methylphenyl)pyridazin-3-yl]morpholin-2-yl]methyl]-2-methylpropanamide; (286) (4S)-4-hydroxy-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-2-one; (287) (3R)-3-(hydroxymethyl)-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-2-one; (288) (3S)-3-(hydroxymethyl)-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-2-one; (289) 3-methyl-2-[6-[rac-(4aR,7aR)-6-methyl-2,3,4a,5,7,7a-hexahydropyrrolo[3,4-b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol; (290) (4aR,8aR)-1-[6-(2-hydroxy-4,6-dimethylphenyl)pyridazin-3-yl]-7-methyl-3,4,4a,5,6,8a-hexahydro-2H-1,7-naphthyridin-8-one; (291) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hydro-2Hpyrido[4,3-b][1,4]oxazin-4-yl]-5-(difluoromethyl)pyridazin-3-yl]-3,5-dimethyl-phenol; (292) (4R)-4-(hydroxymethyl)-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-2-one; (293) (4S)-4-(hydroxymethyl)-1-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-2-one; (295) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hydro-2H-pyrido[4,3-b][1,4]oxazin-4-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-methyl-phenol; (296) 2-[6-[(2S,6R)-2-(hydroxymethyl)-6-methyl-morpholin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; Petition 870250081269, de 10 / 09 / 2025, pág. 765 / 792 31 / 48 (297) 2-[6-[(2S,6S)-2-(hydroxymethyl)-6-methyl-morpholin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (298) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hydro-2H-pyrido[4,3-b][1,4]oxazin-4-yl]-4-(difluoromethyl)pyridazin-3-yl]-5-(trifluoromethyl)phenol; (299) 2-[6-[(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexa-hydro-2H-pyrido[4,3-b][1,4]oxazin-4-yl]pyridazin-3-yl]3-methyl-phenol; (300) 1-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-2,3,4,4a,5,6,7,8a-octa-hydro-1,7-naphthyridin-8-one; (301) 2-[6-[(4aR,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hydro-2H-pyrido[4,3-b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (302) 2-[6-[(2R,6R)-2-(hydroxymethyl)-6-methyl-morpholin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (303) 3,5-dimethyl-2-[6-[(2S)-2-(sulfanylmethyl)morpholin-4-yl]pyridazin-3-yl]phenol; (304) 1-[rac-(4aR,8aS)-4-[6-(4-chloro-2-hydroxi-6-methyl-phenyl)pyridazin-3-yl]-3,4a,5,7,8,8a-hexa-hydro-2H-pyrido[4,3-b][1,4]oxazin-6yl]ethanone; (305) 3,5-dimethyl-2-[6-[(2R)-2-(sulfanylmethyl)morpholin-4-yl]pyridazin-3-yl]phenol; (306) 2-[6-[(4aR,8aS)-6-metil-3,4a,5,7,8,8a-hexa-hydro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-(difluorometil)piridazin-3-il]-5-metil-phenol; (307) 5-chloro-3-metil-2-[6-[rac-(4aR,8aS)-6-metil3,4a,5,7,8,8a-hexa-hydro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3il]phenol; (308) 2-[6-[(4aR,8aS)-2,3,4a,5,6,7,8,8a-octa-hydropi-rido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-5-chloro-3-metil-phenol; (309) 2-[6-[(4aS,8aR)-2,3,4a,5,6,7,8,8a-octa-hydropi-rido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-5-chloro-3-metil-phenol; Petition: 870250081269, on September 10, 2025, page. 766 / 792 32 / 48 (310) 2-[6-[(4aR,8aS)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3,5-dimetil-fenol; (311) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3,5-dimetil-fenol; (312) 2-[6-[(4aR,8aS)-6-etil-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-5-chloro-3-methyl-fenol; (313) 2-[6-[(4aS,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-5-chloro-3-methyl-fenol; (314) 2-[6-[(4aR,8aS)-2,3,4a,5,6,7,8,8a-octa-hydropi-rido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3,5-dimetil-phenol; (315) 2-[6-[(4aS,8aR)-2,3,4a,5,6,7,8,8a-octa-hidropi-rido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3,5-dimethyl-fenol; (316) (4R)-4-hidróxi-1-[6-[2-hidróxi-6-metil-4-(trifluorome-til)fenil]piridazin-3-il]piperidin-2-ona; (317) 2-[6-(4-etil-1,11 -dioxa-4,8-diazaspiro[5,6]dodecan-8- il)piridazin-3-il]-3,5-dimetilfenol; (318) 3-methyl-2-[6-[rac-(4aR,7aR)-3,4a,5,6,7,7a-hexa-hi- dro-2H-pirrolo[3,4-b][1,4]oxazin-4-il]piridazin-3-il]-5-(trifluorometil)fenol;chloridrato; (320) 3-methyl-2-[6-[rac-(4aR,7aS)-3,4a,5,6,7,7a-hexa-hi- dro-2H-pirrolo[3,4-b][1,4]oxazin-4-il]piridazin-3-il]-5-(trifluorometil)fenol;chloridrato; (321) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-5-chloro-3-methyl-fenol; (322) 2-[6-[(4aS,8aR)-2,3,4a,5,6,7,8,8a-octa-hidropi-rido[4,3-b][1,4]oxazin-4-il]-4-(difluorometil)piridazin-3-il]-5-methyl-fenol; (323) 2-[6-[(4aS,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]-4-(difluorometil)piridazin-3-il]-5-methyl-fenol; (324) 5-[6-[(2S)-2-(hydrroximetil)morfolin-4-il]-4-metil-piridazin-3-il]indan-4-ol; Petition: 870250081269, on September 10, 2025, page. 767 / 792 33 / 48 (325) (3R)-3-(hidroximetil)-1-[6-[2-hidróxi-6-metil-4-(trifluorometil)fenil]piridazin-3-il]pirrolidin-2-ona; (326) (3S)-3-(hidroximetil)-1-[6-[2-hidróxi-6-metil-4-(trifluorometil)fenil]piridazin-3-il]pirrolidin-2-ona; (327) 2-[(2R)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3-yl]morpholin-2-yl]acetonitrile; (328) 2-[(2S)-4-[6-[2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl]pyridazin-3-yl]morpholin-2-yl]acetonitrile; (329) (6R)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-6-(hydroxymethyl)piperazin-2-one; (330) (6S)-4-[6-(2-hydroxy-4,6-dimethyl-phenyl)pyridazin-3-yl]-6-(hydroxymethyl)piperazin-2-one; (331) 3-methyl-2-[6-[(2R)-2-[2-(methylamino)ethyl]morpholin-4-yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol; (332) 3-methyl-2-[6-[(2S)-2-[2-(methylamino)ethyl]morpholin-4-yl]pyridazin-3-yl]-5-(trifluoromethyl)phenol; (333) 2-[6-[(4aR,7aS)-6-methyl-2,3,4a,5,7,7a-hexa-hydropyrrolo[3,4-b][1,4]oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (334) 2-[6-[(4aS,7aR)-6-methyl-2,3,4a,5,7,7a-hexa-hydropyrrolo[3,4-b][1,4] oxazin-4-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (335) 1-[rac-(4aR,7aS)-4-[6-[2-hidróxi-6-metil-4-(trifluo metil)fenil]pyridazin-3-il]-2,3,4a,5,7,7a-hexa-hidropirrolo[3,4-b][1,4]oxazin-6-il]etanona; (336) 1-[(4aR,8aR)-4-[6-[2-hidróxi-6-metil-4-(trifluorome- til)fenil]piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6-il]etanona; (337) 1 -[rac-(4aR,7aR)-4-[6-[2-hidróxi-6-metil-4-(trifluoro- metil)fenil]piridazin-3-il]-2,3,4a,5,7,7a-hexa-hydropirrolo[3,4-b][1,4]oxazin-6-il]etanona; Petition: 870250081269, on September 10, 2025, page. 768 / 792 34 / 48 (338) 5-chloro-2-[6-[(2R)-2-(fluorometil)morfolin-4-il]piridazin-3-il]-3-metil-phenol; (339) 5-chloro-2-[6-[(2S)-2-(fluorometil)morfolin-4-il]piridazin-3-il]-3-metil-phenol; (340) 2-[6-[(rac-3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hi- dro-2H-pirrolo[2,3-c]piridin-1-il]-4-methyl-piridazin-3-il]-5-(trifluorometil)fenol; (341) 2-[6-[(rac-3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hi- dro-2H-pirrolo[2,3-c]piridin-1-il]-4-metil-piridazin-3-il]-5-metil-fenol; (342) 3,5-dimethyl-2-[6-[rac-(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3-c]piridin-1-il]piridazin-3-il]fenol; (343) 2-[6-[(4aS,8aS)-6-metil-3,4a,5,7,8,8a-hexa-hydro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3-metil-5-(trifluorometil)phenol; (344) 2-[6-[(4aR,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (345) 5-[4-(difluorometil)-6-[(2S)-2-(hydrroximetil)morfolin-4il]piridazin-3-il]indan-4-ol; (346) 3-metil-2-[6-[rac-(3aS,6aS)-2,3,3a,5,6,6a-hexa-hi- dro-1H-pirrolo[3,2-b]pirrol-4-il]piridazin-3-il]-5-(trifluorometil)phenol;cloridrato; (348) 1-[(4aR,7aS)-4-[6-[2-hidróxi-6-methyl-4-(trifluorometil)fenil]pyridazin-3-il]-2,3,4a,5,7,7a-hexa-hidropirrolo[3,4-b][1,4]oxazin6-il]etanona; (349) 1-[(4aS,8aS)-4-[6-[2-hidróxi-6-metil-4-(trifluorom til)fenil]piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6-il]etanona; (350) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-(difluorometil)piridazin-3-il]-5-chloro-fenol; (351) 2-[6-[(4aS,8aR)-6-metil-3,4a,5,7,8,8a-hexa-hydro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-(difluorometil)piridazin-3-il]-6-fluoro-phenol; Petition: 870250081269, on September 10, 2025, page. 769 / 792 35 / 48 (352) 1-[(4aS,7aR)-4-[6-[2-hidróxi-6-methyl-4-(trifluorome- til)fenil]pyridazin-3-il]-2,3,4a,5,7,7a-hexa-hidropirrolo[3,4-b][1,4]oxazin6-il]etanona; (353) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-6-fluoro-3-methyl-fenol; (354) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]3-methyl-fenol; (355) 2-[6-[(4aS,8aR)-6-(2,2,2-trifluoroetil)-3,4a,5,7,8,8ahexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3,5-dimetil-fenol; (356) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-metil-piridazin-3-il]-6-fluoro-fenol; (357) 1-[(4aS,8aR)-4-[6-(4-chloro-2-hidróxi-fenil)-5-metil-pi-ridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6il]etanona; (358) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]3-etyl-fenol; (359) 2-[6-[(2S,6R)-2-(hydrroximetil)-6-metil-morfolin-4-il]piridazin-3-il]-3,5-dimetil-phenol; (360) 2-[6-(5,6-di-hydro-2H-pirazolo[4,3-b][1,4]oxazin-7- il)piridazin-3-il]-3-metil-5-(trifluorometil)phenol; (361) 3-methyl-2-[6-[rac-(4aR,7aS)-6-etil-2,3,4a,5,7,7a-hexa-hidropirrolo[3,4-b][1,4]oxazin-4-il]piridazin-3-il]-5-(trifluorometil)fenol; (362) 2-[6-(2,3-di-hidropirido[4,3-b][1,4]oxazin-4-il)pirida-zin-3-il]-3,5-dimethyl-fenol; (363) 1 -[(4aS,8aR)-4-[6-[2-hidróxi-4-(trifluorometil)fenil]-5- metil-piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6-il]etanona; Petition: 870250081269, on September 10, 2025, page. 770 / 792 36 / 48 (364) 2-[6-[rac-(3aS,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hi- dro-2H-pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (365) 2-[6-[(2R,6R)-2-(hydrroximetil)-6-metil-morfolin-4-il]piridazin-3-il]-3,5-dimetil-phenol; (366) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-methyl-piridazin-3-il]-5-(trifluorometil)fenol; (367) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-methyl-piridazin-3-il]-5-(trifluorometil)fenol; (368) 2-(hidroximetil)-4-[6-[2-hidróxi-6-metil-4-(trifluorometil)fenil]piridazin-3-il]morfolin-3-ona; (369) 1-[(3aR,7aR)-1-[6-[2-hidróxi-6-metil-4-(trifluorome- til)fenil]piridazin-3-il]-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3-c]piridin-6il]etanona; (370) 1-[(3aS,7aS)-1-[6-[2-hidróxi-6-methyl-4-(trifluorome- til)fenil]pyridazin-3-il]-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3-c]piridin6-il]etanona; (371) 2-[6-[rac-(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hi- dro-2H-pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (372) (4S)-1-[5-(difluorometil)-6-[2-hidróxi-6-metil-4-(trifluorometil)fenil]piridazin-3-il]-4-hidróxi-pirrolidin-2-ona; (373) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-metil-piridazin-3-il]-5-metil-fenol; (374) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-metil-piridazin-3-il]-5-metil-fenol; (375) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-metil-piridazin-3-il]-5-metil-fenol; Petição 870250081269, dated 10 / 09 / 2025, pág. 771 / 792 37 / 48 (376) 3-methyl-2-[6-[rac-(4aR,7aR)-6-etil-2,3,4a,5,7,7a-hexa-hidropirrolo[3,4-b][1,4]oxazin-4-il]piridazin-3-il]-5-(trifluorometil)fenol; (377) 1 -[rac-(3aS,6aS)-1-[6-[2-hidróxi-6-metil-4-(trifluoro- metil)fenil]piridazin-3-il]-2,3,3a,5,6,6a-hexa-hydropirrolo[3,2-b]pirrol-4il]etanona; (378) 2-[6-[rac-(3aS,7aR)-6-etil-3,3a,4,5,7,7a-hexa-hidro- 2H-pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (379) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-metil-piridazin-3-il]-5-chloro-fenol; (380) 1-[(4aS,8aR)-4-[6-[2-etil-6-hidróxi-4-(trifluorometil)fe- nil]piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6il]etanona; (381) 1 -[(4aS,8aR)-4-[6-(4-chloro-2-etil-6-hidróxi-fenil)piri- dazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6-il]etanona; (382) 2-[6-[(4aS,8aR)-2,3,4a,5,6,7,8,8a-octa-hydropi-rido[4,3-b][1,4]oxazin-4-il]-4-(difluorometil)piridazin-3-il]-5-(trifluorometil)phenol; (383) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3,5-dimetil-fenol; (384) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3,5-dimetil-fenol; (385) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-fenol; (386) 1-[(4aS,8aR)-4-[5-(difluorometil)-6-[2-hidróxi-4-(trifluorometil) fenil]piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3b][1,4]oxazin-6-il]etanona; Petition: 870250081269, on September 10, 2025, page. 772 / 792 38 / 48 (387) 1-[(4aS,8aR)-4-[5-(difluorometil)-6-(2-hidróxi-4-methyl-fenil)piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin6-il]etanona; (388) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-etyl-fenol; (389) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-(trifluorometil)fenol; (390) 2-[6-[(2S,6S)-2-(hydrroximetil)-6-metil-morfolin-4-il]piridazin-3-il]-3,5-dimetil-phenol; (391) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (392) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (393) 2-[6-[(3aR,7aS)-2,3,3a,4,5,6,7,7a-octa-hidropir- rolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (394) 1 -[(3aR,7aR)-1-[6-(2-hidróxi-4,6-dimetil-fenil)pirida- zin-3-il]-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3-c]piridin-6-il]etanona; (395) 1-[(3aR,7aR)-1-[6-[2-hidróxi-6-metil-4-(trifluorome- til)fenil]piridazin-3-il]-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3-c]piridin-6il]etanona; (397) 1-[(4aS,8aR)-4-[6-(4-chloro-2-hidróxi-6-metil-fenil)piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6-il]etanona; (398) 1 -[(4aR,8aS)-4-[6-[2-hidróxi-6-metil-4-(trifluorome-til)fenil]piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6-il]etanona; (399) 3,5-dicloro-2-[6-(1,1-dioxo-1,4-tiazinan-4-il)piridazin- 3-il]phenol; (400) 3,5-dicloro-2-[6-(1-oxo-1,4-tiazinan-4-il)piridazin-3- il]phenol; Petition: 870250081269, on September 10, 2025, page. 773 / 792 39 / 48 (402) 2-[6-[(4aS,8aR)-6-metil-3,4a,5,7,8,8a-hexa-hydro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3-(trifluorometil)phenol; (403) 3,5-dimethyl-2-[6-[rac-(4aS,8aR)-3,4a,5,7,8,8a-hexa- hidro-2H-pirano[4,3-b][1,4]oxazin-4-il]piridazin-3-il]fenol; (404) 2-[6-[(4aS,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hydro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3,5-dimetil-phenol; (405) 1-[(4aS,8aR)-4-[4-(difluorometil)-6-(2-hidróxi-4,6-di- metil-fenil)piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3b][1,4]oxazin-6-il]etanona; (406) 2-[6-[(3aS,7aR)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (407) 2-[6-[(3aS,7aR)-2,3,3a,4,5,6,7,7a-octa-hidropir- rolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (408) 2-[6-[(4aS,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hydro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]3-etil-phenol; (409) 1 -[(4aS,8aR)-4-[6-(2-hidróxi-6-metil-fenil)piridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6-il]etanona; (410) 3,5-dimetil-2-[6-(3-metil-3,6-diazabiclo[3,2,2]no-nan-6-il)piridazin-3-il]phenol; (411) 2-[6-[(4aS,8aR)-2,3,4a,5,6,7,8,8a-octa-hidropi- rido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3-methyl-fenol; (412) 2-[6-[(4aS,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]3-methyl-fenol; (413) 1 -[(3aR,7aR)-1-[6-(2-hidróxi-4,6-dimetil-fenil)pirida- zin-3-il]-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3-c]piridin-6-il]etanona; (414) 1-[(3aS,7aS)-1-[6-(2-hidróxi-4,6-dimetil-fenil)pirida-zin-3-il]-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3-c]piridin-6-il]etanona; (415) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-fenol; Petição 870250081269, dated 10 / 09 / 2025, pág. 774 / 792 40 / 48 (416) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-fenol; (417) 3-metil-2-[6-(3-metil-3,6-diazabiclo[3,2,2]nonan-6- il)piridazin-3-il]-5-(trifluorometil)phenol; (418) 3-etil-2-[6-[(2S)-2-(hydrroximetil)morfolin-4-il]piridazin- 3-il]-5-(trifluorometil)phenol; (419) (2S)-2-(hidroximetil)-4-[6-[2-hidróxi-6-metil-4-(trifluorometil)fenil]piridazin-3-il]morfolin-3-ona; (420) (2R)-2-(hidroximetil)-4-[6-[2-hidróxi-6-metil-4-(trifluorometil)fenil]piridazin-3-il]morfolin-3-ona; (421) 3,5-dimethyl-2-[6-[rac-(4aS,8aS)-3,4a,5,7,8,8a-hexa- hidro-2H-pirano[4,3-b][1,4]oxazin-4-il]piridazin-3-il]fenol; (422) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-etyl-fenol; (423) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-etyl-fenol; (424) 1-[(4aS,8aR)-4-[6-(2-etil-6-hidróxi-fenil)piridazin-3-il]- 3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6-il]etanona; (425) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-5-(difluorometil)piridazin-3-il]-3-etyl-fenol; (426) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-(trifluorometil)fenol; (427) 2-[6-[rac-(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hi- dro-2H-pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-(trifluorometil)fenol; (428) 3,5-dimetil-2-[6-(9-metil-1,9-diazaspiro[4,5]decan-1- il)piridazin-3-il]phenol; (429) 2-[6-[(3aR,7aS)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-5-(trifluorometil)fenol; (430) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-methyl-piridazin-3-il]-5-(trifluorometil)-phenol; Petição 870250081269, dated 10 / 09 / 2025, pág. 775 / 792 41 / 48 (431) 1 -[(4aS,8aR)-4-[6-(2-hidróxi-4-metil-fenil)-5-metil-pi-ridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6il]etanona; (432) 2-[6-[(4aS,8aR)-6-isopropil-3,4a,5,7,8,8a-hexa-hydro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]3-etil-phenol; (433) 2-[6-[(4aS,8aR)-6-isopropil-3,4a,5,7,8,8a-hexa-hydro- 2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3,5-dimetil-phenol; (434) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-5-methyl-piridazin-3-il]-3,5-dimetil-fenol; (435) 2-[6-[(4aS,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-metil-piridazin-3-il]-5-metil-fenol; (436) 2-[6-[(4aS,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-metil-piridazin-3-il]-5-(trifluorometil)-fenol; (437) 2-[6-[(4aS,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-metil-piridazin-3-il]-5-chloro-fenol; (438) 3-methyl-2-[6-[rac-(4aS,8aR)-3,4a,5,7,8,8a-hexa-hi- dro-2H-pirano[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-5-(trifluorometil)fenol; (439) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-5-metil-piridazin-3-il]-3-etyl-fenol; (440) 3,5-dimetil-2-[6-(9-metil-6-oxa-2,9-diazaspiro[4,5]de-can-2-il)piridazin-3-il]phenol; (441) 3,5-dimetil-2-[6-(1-metil-4-oxa-1,8-diazaspiro[5,5]un-decan-8-il)piridazin-3-il]phenol; (442) 1-[(4aS,8aR)-4-[6-(4-chloro-2-hidróxi-fenil)-5-(difluorometil)pyridazin-3-il]-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-6-il]etanona; (443) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-etyl-piridazin-3-il]-5-(trifluorometil)-fenol; (444) 3,5-dimetil-2-[6-(6-metil-9-oxa-2,6-diazaspiro[4,5]de-can-2-il)piridazin-3-il]phenol; Petition: 870250081269, on September 10, 2025, page. 776 / 792 42 / 48 (445) 3,5-dimetil-2-[6-[(5S)-9-metil-6-oxa-2,9-diazas- piro[4,5]decan-2-il]piridazin-3-il]phenol; (446) 3,5-dimetil-2-[6-[(5R)-9-metil-6-oxa-2,9-diazas-pyro[4,5]decan-2-il]piridazin-3-il]phenol; (448) 3-metil-2-[6-[rac-(4aS,8aS)-3,4a,5,7,8,8a-hexa-hi- dro-2H-pirano[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-5-(trifluorometil)phenol; (449) 3,5-dimetil-2-[6-(8-metil-4-oxa-1,8-diazaspiro[5,5]un-decan-1-il)piridazin-3-il]phenol; (450) 3,5-dimetil-2-[6-[(5R)-6-metil-9-oxa-2,6-diazas- piro[4,5]decan-2-il]piridazin-3-il]phenol; (451) 3,5-dimetil-2-[6-[(5S)-6-metil-9-oxa-2,6-diazas-pyro[4,5]decan-2-il]piridazin-3-il]phenol; (452) 2-[6-[rac-(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hi- dro-2H-pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-etil-5-(trifluorometil)fenol; (455) 3,5-dimetil-2-[6-(2-metil-8-oxa-2,5-diazaspiro[3,5]no-nan-5-il)piridazin-3-il]phenol; (456) 2-[6-[(4aS,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-(difluorometil)piridazin-3-il]-5-chloro-fenol; (457) 1 -[(3aR,7aR)-1-[6-(2-hidróxi-4-metil-fenil)-5-metil-pi-ridazin-3-il]-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3-c]piridin-6-il]etanona; (458) 2-[6-[rac-(3aS,7aR)-6-etil-3,3a,4,5,7,7a-hexa-hidro- 2H-pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-(trifluorometil)fenol; (459) 2-[6-[rac-(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hi- dro-2H-pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-etil-5-methyl-fenol; (460) 2-[6-[rac-(3aS,7aR)-6-etil-3,3a,4,5,7,7a-hexa-hidro- 2H-pirrolo[2,3-c]piridin-1-il]-4-metil-piridazin-3-il]-5-metil-fenol; (461) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-5-chloro-3-etyl-fenol; Petição 870250081269, dated 10 / 09 / 2025, pág. 777 / 792 43 / 48 (462) 1 -[(4aR,8aR)-5-[6-[2-hidróxi-6-metil-4-(trifluorome-til)fenil]piridazin-3-il]-2,3,4,4a,6,7,8,8a-octa-hidro-1,5-naftiridin-1-il]etanona; (463) 1 -[(4aS,8aS)-5-[6-[2-hidróxi-6-metil-4-(trifluorom til)fenil]piridazin-3-il]-2,3,4,4a,6,7,8,8a-octa-hidro-1,5-naftiridin-1-il]etanona; (466) (4aS,6S,7aR)-4-[6-(2-hidróxi-4,6-dimetil-fenil)piridazin-3-il]-3,4a,5,6,7,7a-hexa-hidro-2H-ciclopenta[b][1,4]oxazin-6-ol; (467) (4aR,6R,7aS)-4-[6-(2-hidróxi-4,6-dimetil-fenil)piridazin-3-il]-3,4a,5,6,7,7a-hexa-hidro-2H-ciclopenta[b][1,4]oxazin-6-ol; (468) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-metil-piridazin-3-il]-5-chloro-fenol; (469) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-metil-piridazin-3-il]-5-chloro-fenol; (470) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-etil-piridazin-3-il]-5-metil-fenol; (471) 5-[6-[(4aS,8aR)-6-metil-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]-4-metil-piridazin-3-il]indan-4-ol; (472) 2-[6-[(4aS,8aR)-6-isopropyl-3,4a,5,7,8,8a-hexa-hidro- 2H-pirido[4,3-b][1,4]oxazin-4-il]-4-methyl-piridazin-3-il]-5-methyl-fenol; (473) 2-[6-[(3aS,7aR)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-(trifluorometil)fenol; (474) 2-[6-[(3aR,7aS)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-metil-piridazin-3-il]-5-metil-fenol; (475) 2-[6-[(3aS,7aR)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-metil-piridazin-3-il]-5-metil-fenol; (476) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-etil-5-methyl-fenol; (477) 2-[6-[(3aS,7aR)-6-metil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-etil-5-metil-fenol; Petição 870250081269, de 10 / 09 / 2025, pág. 778 / 792 44 / 48 (479) 2-[6-[(4aS,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]-4-metil-piridazin-3-il]-5-fluoro-fenol; (480) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]-4-metil-piridazin-3-il]-5-fluoro-fenol; (481) 2-[6-[(4aS,8aR)-6-methyl-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-3-etil-5-(trifluorometil)fenol; (482) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-(difluorometil)piridazin-3-il]-5-(trifluorometil)fenol; (483) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-(difluorometil)piridazin-3-il]-5-(trifluorometil)fenol; (484) 3-metil-2-[6-[rac-(3aS,6aS)-1 -metil-2,3,3a,5,6,6a- hexa-hydropirrolo[3,2-b]pirrol-4-il]piridazin-3-il]-5-(trifluorometil)phenol; (485) 2-[6-[(3aR,7aS)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-(difluorometil)piridazin-3-il]-5-(trifluorometil)fenol; (486) 2-[6-[(3aS,7aR)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-(difluorometil)piridazin-3-il]-5-(trifluorometil)fenol; (487) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-5-(difluorometil)piridazin-3-il]-3,5-dimetil-fenol; (488) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-5-(difluorometil)piridazin-3-il]-3,5-dimetil-fenol; (489) 2-[6-[(3aR,7aS)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-(difluorometil)piridazin-3-il]-5-methyl-fenol; (490) 2-[6-[(3aS,7aR)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-(difluorometil)piridazin-3-il]-5-methyl-fenol; (491) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-etyl-5-(trifluorometil)fenol; Petição 870250081269, dated 10 / 09 / 2025, pág. 779 / 792 45 / 48 (492) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-etil-5-(trifluorometil)fenol; (493) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-5-chloro-3-etyl-fenol (494) 2-[6-[(3aS,7aR)-6-metil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-5-chloro-3-etyl-fenol; (496) 2-[6-[(3aR,7aS)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-5-chloro-3-methyl-fenol; (497) 2-[6-[(3aS,7aR)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-5-chloro-3-methyl-fenol; (498) 2-[6-[(3aS,7aR)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-fenol; (499) 2-[6-[(3aR,7aS)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3-methyl-fenol; (500) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-(difluorometil)piridazin-3-il]-5-chloro-fenol; (501) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-(difluorometil)piridazin-3-il]-5-chloro-fenol; (502) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-5-chloro-3-methyl-fenol; (503) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-5-chloro-3-methyl-fenol; (504) 2-[6-[(3aS,7aR)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3,5-dimetil-fenol; (505) 2-[6-[(3aR,7aS)-6-etil-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]piridazin-3-il]-3,5-dimetil-fenol; (506) 2-[6-[(3aR,7aS)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H- pirrolo[2,3-c]piridin-1-il]-4-(difluorometil)piridazin-3-il]-5-methyl-fenol; (507) 2-[6-[(3aS,7aR)-6-methyl-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3-c]piridin-1-il]-4-(difluorometil)piridazin-3-il]-5-methyl-fenol; Petição 870250081269, dated 10 / 09 / 2025, pág. 780 / 792 46 / 48 (508) 5-etinil-2-[6-[(2S)-2-(hydrroximetil)morfolin-4-il]pirida-zin-3-il]-3-metil-phenol; (509) 2-[6-[(2S)-2-(hydrroximetil)morfolin-4-il]piridazin-3-il]5-metil-3-(trifluorometil)phenol; (510) 1-[(3aS,7aS)-1-[5-(difluorometil)-6-[2-hidróxi-4-(triflu- orometil) fenil]piridazin-3-il]-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3c]piridin-6-il]etanona; (511) 1-[(3aR,7aR)-1-[5-(difluorometil)-6-[2-hidróxi-4-(triflu- orometil) fenil]piridazin-3-il]-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3c]piridin-6-il]etanona; (512) 1-[(3aS,7aS)-1-[4-(difluorometil)-6-(2-hidróxi-4,6-dimetil-fenil)piridazin-3-il]-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3-c]piridin-6-il]etanona; (513) 1-[(3aR,7aR)-1-[4-(difluorometil)-6-(2-hidróxi-4,6-di- metil-fenil)piridazin-3-il]-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3-c]piridin-6-il]etanona; (514) 1-[(3aR,7aR)-1-[6-[2-hidróxi-4-(trifluorometil)fenil]-5- metil-piridazin-3-il]-3,3a,4,5,7,7a-hexa-hidro-2H-pirrolo[2,3-c]piridin-6il]etanona; (515) 2-[6-[(4aS,8aS)-5-metil-2,3,4,4a,6,7,8,8a-octa-hydro-1,5-naftiridin-1-il]piridazin-3-il]-3-metil-5-(trifluorometil)phenol; (516) 2-[6-[(4aR,8aR)-5-metil-2,3,4,4a,6,7,8,8a-octa-hydro-1,5-naftiridin-1-il]piridazin-3-il]-3-metil-5-(trifluorometil)phenol; (517) 2-[6-[(4aR,8aS)-7-methyl-2,3,4,4a,5,6,8,8a-octa-hydro-1,7-naphthyridin-1-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (518) 2-[6-[(4aS,8aS)-7-methyl-2,3,4,4a,5,6,8,8a-octa-hydro-1,7-naphthyridin-1-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (519) 2-[6-[(4aR,8aR)-7-methyl-2,3,4,4a,5,6,8,8a-octa-hydro-1,7-naphthiridin-1-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; Petition 870250081269, de 10 / 09 / 2025, pág. 781 / 792 47 / 48 (520) 2-[6-[(4aS,8aR)-7-methyl-2,3,4,4a,5,6,8,8a-octa-hydro-1,7-naphthyridin-1-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (521) 2-[6-[(4aS,8aR)-6-(2-fluoroethyl)-3,4a,5,7,8,8a-hexa-hydro-2H-pyrido[4,3-b][1,4]oxazin-4-yl]pyridazin-3-yl]-3,5-dimethyl-phenol; (522) 2-[6-[(4aS,8aR)-6-(2-fluoroethyl)-3,4a,5,7,8,8a-hexa-hydro-2H-pyrido[4,3-b][1,4]oxazin-4-yl]pyridazin-3-yl]-5-chloro-3-methyl-phenol; (523) 2-[6-[(4aR,8aR)-7-methyl-2,3,4,4a,5,6,8,8a-octa-hydro-1,7-naphthyridin-1-yl]pyridazin-3-yl]-3-methyl-5-(trifluoromethyl)phenol; (524) 2-[6-[(4aS,8aS)-7-metil-2,3,4,4a,5,6,8,8a-octa-hydro-1,7-naftiridin-1-il]piridazin-3-il]-3-metil-5-(trifluorometil)phenol; (525) 2-[6-[(4aS,8aR)-6-(2-fluoroetil)-3,4a,5,7,8,8a-hexa- hidro-2H-pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-5-chloro-fenol; (526) 2-[6-[(4aS,8aR)-6-etil-3,4a,5,7,8,8a-hexa-hidro-2H- pirido[4,3-b][1,4]oxazin-4-il]piridazin-3-il]-5-chloro-3-etil-fenol; (527) 2-[6-[(4aS,8aR)-6-(3-fluoropropyl)-3,4a,5,7,8,8a-hexahydro-2H-pyrido[4,3-b][1,4]oxazine-4-yl]pyridazin-3-yl]-3,5-dimethylphenol; and (528) 5-methyl-2-[4-methyl-6-[rac-(3aS,7aR)-6-isopropyl-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-1-yl]pyridazin-3-yl]phenol.
10. Medicament, characterized in that it comprises a compound of formula (I), as defined in any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof.
11. Pharmaceutical composition, characterized in that it comprises a compound of formula (I), as defined in any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.
12. Compound of formula (I), according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof, characterized in that it is for use as a medicament. Petition 870250081269, dated 10 / 09 / 2025, pp. 782 / 792 48 / 48 13.Compound of formula (I), according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof, characterized in that it is for use as an inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome.
14. Compound of formula (I), according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof, characterized in that it is for use in the prevention and / or treatment of Parkinson's disease, frontotemporal dementia, multiple system atrophy, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, or brain injury.