Use of thioridazine hydrochloride or a pharmaceutical composition thereof for preparing an antitumor drug

Thioridazine hydrochloride was used to prepare an anti-tumor drug by targeting the PARP1-mTOR protein interaction, which solved the problem of limited efficacy in the treatment of neuroblastoma and achieved significant tumor-suppressing effects and safety verification.

CN122398811APending Publication Date: 2026-07-17XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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Patent Information

Application Number
CN202610635462.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-09
Publication Date
2026-07-17

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Abstract

本发明涉及盐酸硫利哒嗪或其药物组合物在制备抗肿瘤药物中的应用，本发明发现盐酸硫利哒嗪可减弱PARP1与mTOR的蛋白结合，进而抑制下游信号通路，显著降低肿瘤细胞增殖、克隆形成、迁移 / 侵袭能力，并提供盐酸硫利哒嗪在治疗神经母细胞瘤及其他PARP1 / mTOR依赖性肿瘤中的新用途，通过特异性抑制PARP1与mTOR的蛋白相互作用，克服现有单一通路抑制剂的局限性，并实现老药新用。
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