IRE-1α inhibitors

Abstract

The present invention provides compounds, prodrugs, and pharmaceutically acceptable salts thereof that directly inhibit IRE-1α activity in vitro. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.

Description

[0001] This application claims the benefit of Serial No. 61 / 320,975, filed April 5, 2010, and is incorporated by reference thereto.

[0002] Each patent, patent application, and reference cited in this disclosure is expressly incorporated herein by reference in its entirety. Field of the Invention

[0003] The field of the invention includes IRE-1α inhibitors and their therapeutic uses.

[0004] background

[0005] Protein folding stress in the endoplasmic reticulum (ER) triggers a signaling cascade known as the unfolded protein response (UPR). Inositol-requiring enzyme 1α (IRE-1α) is a key enzyme that alleviates protein folding stress by enhancing chaperone activity, thereby protecting cells from stress-induced apoptosis. Inhibitors of IRE-1α have potential uses in treating at least B-cell autoimmune diseases, certain cancers, and some viral infections. BRIEF DESCRIPTION OF THE DRAWINGS

[0007] Figure 1 Shown is the inhibition of endogenous XBP-1 splicing in RPMI 8226 cells using 10 μM IRE-1α ribonuclease inhibitor (Cmpd) and thapsigargin (Tg). PCR amplification products were run on a 4% agarose gel and stained with ethidium bromide. Reverse images are shown.

[0008] FIG2 shows the inhibition of Blos1 ( Figure 2A ) and CD59( Figure 2B ) Regulated IRE1-dependent decay (RIDD). GAPDH ( Figure 2C ) is shown as a control. Cells were left untreated or treated with 10 μM IRE-1α inhibitor or 300 nM thapsigargin (Tg), or both, for 2, 4, 6, 8, 16, or 24 hours. Total RNA was harvested and RT-qPCR was performed using primers specific for each individual mRNA. Expression levels are shown as Ct values, where one PCR cycle is associated with a 2-fold change.

[0009] Figure 3A .Time course of the experiment described in Example 44.

[0010] Figure 3B Results of RT-PCR analysis using mouse-specific XBP-1 primers from total RNA harvested from the indicated organs following intraperitoneal treatment with an IRE-1α inhibitor (Example 44).

[0011] Figure 4A Results of RT-PCR analysis using mouse-specific XBP-1 primers from total RNA harvested from the indicated organs following intravenous treatment with an IRE-1α inhibitor (Example 44).

[0012] Figure 4B Results of RT-PCR analysis using mouse-specific XBP-1 primers from total RNA harvested from the indicated organs after oral treatment with an IRE-1α inhibitor (Example 44).

[0013] Figure 5A .Time course of the experiment described in Example 45.

[0014] Figure 5B Results of RT-PCR amplification of XBP-1 using human-specific primers.

[0015] Figure 6A .Time course of the experiment described in Example 46.

[0016] Figure 6B Results of RT-PCR amplification of XBP-1 using human-specific primers.

[0017] Details

[0018] This specification describes IRE-1α inhibitor compounds and prodrugs, and pharmaceutically acceptable salts thereof; purified preparations of IRE-1α inhibitor compounds and prodrugs, and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising IRE-1α inhibitor compounds and prodrugs, and pharmaceutically acceptable salts thereof; and methods of using IRE-1α inhibitor compounds, prodrugs, and pharmaceutically acceptable salts thereof to therapeutically treat conditions associated with an unfolded protein response. Patients that can be treated include those with B-cell autoimmune diseases, certain cancers, and some viral infections. In other embodiments, IRE-1α inhibitor compounds, prodrugs, or pharmaceutically acceptable salts thereof can be administered to treat conditions associated with regulated IRE1-dependent decay (RIDD). Further embodiments are intermediates to IRE-1α inhibitor compounds and methods of synthesizing IRE-1α inhibitor compounds, as listed in the specific examples below.

[0019] definition

[0020] "Halogen" includes fluorine, chlorine, bromine and iodine.

[0021] Unless otherwise indicated, the term "alkyl" as used herein refers to a saturated monovalent hydrocarbon group having 1, 2, 3, 4, 5, or 6 carbon atoms ("C1-C6 alkyl") and can be linear, branched, or a combination thereof. "C1-C6 alkyl" includes C1-C5 alkyl, C1-C4 alkyl, and C1-C3 alkyl. Examples of C1-C6 alkyl include methyl, ethyl, propyl, isopropyl, sec-butyl, tert-butyl, n-butyl, 2-butyl, pentyl, and hexyl.

[0022] As used herein, "alkoxy" refers to -O-alkyl, wherein "alkyl" is as defined above and can be linear, branched, or a combination thereof. Examples of C1-C6 alkoxy groups include, for example, methoxy, ethoxy, propoxy, 2-propoxy, butoxy, sec-butoxy, and tert-butoxy.

[0023] The term "perfluoroalkyl" refers to an alkyl group as defined above wherein all hydrogen atoms are replaced by fluorine atoms. The term "perfluoroalkoxy" refers to an alkoxy group wherein the alkyl portion is a perfluoroalkyl group as defined above.

[0024] The term "hydroxyalkyl" as used herein refers to an alkyl group as defined above substituted with a hydroxy group.

[0025] The term "alkoxyalkyl" refers to a group of the formula C a H 2a+1 -O-(CH2) b -, wherein a and b are independently 1, 2, 3, 4, 5 or 6.

[0026] "Cycloalkyl" is a saturated or partially saturated 3- to 14-membered (i.e., 3-, 4-, 5-, 6, 7-, 8-, 9-, 10-, 11-, 12-, 13-, or 14-membered) monocyclic or polycyclic ring, such as a 5-, 6-, or 7-membered monocyclic ring or a 10-membered bicyclic ring, in which all ring members are carbon atoms. Examples of cycloalkyl groups include cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl.

[0027] "Aryl," when used alone or as part of another term, refers to a carbocyclic aromatic ring containing from 5 to 14 members (e.g., 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 members) and can be monocyclic or polycyclic. Examples of aryl groups include phenyl, naphthyl, anthracenyl, and phenanthrenyl.

[0028] "Heterocycle," "heterocyclyl," and "heterocyclic ring" are saturated or partially saturated 4- to 14-membered (i.e., 4-, 5-, 6-, 7-, 8-, 9-, 10-, 11-, 12-, 13-, or 14-membered) monocyclic or polycyclic (fused) rings, such as 5-, 6-, or 7-membered monocyclic rings or 10-membered bicyclic rings, having 1, 2, 3, or 4 heteroatoms selected from nitrogen (N), oxygen (O), and sulfur (S). Any of the nitrogen and sulfur heteroatoms are optionally oxidized, and any nitrogen heteroatom may be optionally quaternized. The heterocyclic ring may be attached at any suitable heteroatom or carbon atom. Examples of heterocycles include azepine, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazolyl, isobenzofuranyl, furazanyl, indolyl, quinolinyl, oxazolyl, imidazolinyl, isoxazolyl, quinolinyl, naphthyridinyl, phenoxazinyl, phenanthridinyl, chromenyl, triazinyl, purinyl, benzothienyl, benzimidazolyl, benzopyranyl, benzothiazolyl, benzoxazolyl, benzo[b]thienyl, naphtho[2,3-b]-thienyl, isothiazolyl, thiazolyl, isothiazolyl, isoquinolinyl, thiadiazolyl, oxadiazolyl, tetrahydroquinolinyl, indolizinyl, isoindolyl, indazolyl, isoquinolinyl, phthalazinyl, tetrahydroquinolinyl, and cinnolinyl.

[0029] "Heteroaryl" is a saturated 4- to 14-membered (i.e., 4-, 5-, 6-, 7-, 8-, 9-, 10-, 11-, 12-, 13-, or 14-membered) monocyclic or polycyclic (fused) ring having 1, 2, 3, or 4 heteroatoms selected from nitrogen (N), oxygen (O), and sulfur (S), such as a 5-, 6-, or 7-membered monocyclic ring or a 10-membered bicyclic ring. Any of the nitrogen and sulfur heteroatoms are optionally oxidized, and any nitrogen heteroatom may be optionally quaternized. The heteroaryl group may be attached to any suitable heteroatom or carbon atom. Examples of heteroaryl groups include pyridyl, imidazolyl, pyrrolyl, thienyl, furyl, pyranyl, pyrimidinyl, pyridazinyl, indolyl, quinolinyl, naphthyridinyl, and isoxazolyl.

[0030] IRE-1α inhibitor compounds

[0031] IRE-1α inhibitor compounds directly inhibit IRE-1α. It is understood that the compounds act by inhibiting the enzyme's RNase activity. In some embodiments, the IRE-1α inhibitor compounds form a complex with IRE-1α. In certain embodiments, this activity is measured as 10 to 100% in vitro cleavage of the human mini-XBP-1 mRNA stem-loop substrate 5′-CAGUCCGCAGGACUG-3′ (SEQ ID NO: 1) by IRE-1α. Other substrates can also be used to detect cleavage. See US 2007 / 0105123.

[0032] IRE-1α inhibitor compounds may meet either or both of the following criteria:

[0033] a. Some compounds inhibit IRE-1α in vitro 50 The IC values ​​of some of these compounds in this assay are approximately 0.0005-20 μM. 50 The IC values ​​of other compounds in this assay were approximately 1-20 μM. 50 The IC values ​​of other compounds are about 0.1-1 μM. 50 It is about 0.0005-0.1 μM.

[0034] b. Some compounds inhibit the EC of IRE-1α in an in vivo XBP-1 splicing assay (e.g., in myeloma cells) 50 The EC values ​​for some of these compounds in this assay ranged from approximately 0.05 to 80 μM. 50 The EC0 values ​​of other compounds in this test were approximately 10-80 μM. 50 The EC0 of other compounds in this test is about 1-10 μM. 50 It is about 0.05-1 μM.

[0035] The compounds belong to one or more of the following structural formulas. Non-limiting examples of compounds within the scope of these structural formulas are provided in Tables 1 and 2 and in the Examples.

[0036] Some embodiments expressly include, and some embodiments include only, compounds having structural formula (A):

[0037]

[0038] in:

[0039] R3 and R4 are independently hydrogen; halogen; hydroxy; optionally substituted alkyl; or optionally substituted alkoxy; or optionally substituted alkylamino. Optional substituents for the alkyl or alkoxy and alkylamino groups are (1) a C1-C6 hydrocarbon chain containing N or O atoms and optionally substituted with a C1-C3 perfluoroalkyl group, and (2) a cycloalkyl group which may contain 1 or 2 heteroatoms selected from N, O and S and is optionally substituted with a C1-C3 perfluoroalkyl group;

[0040] Q5, Q6, Q7 and Q8 (in the whole specification, can be used interchangeably with Q5, Q6, Q7 and Q8) form a benzo-condensed ring together with the phenyl ring to which they are connected. In some embodiments, Q7 is the key connecting Q6 and Q8. The benzo-condensed ring may or may not be fully aromatic.

[0041] Q5 is CR5, CR5R5′, N, NR5, NC═OR5, O, S or C═O;

[0042] Q6 is CR6, CR6R6′, N, NR6, NC═OR6, O, S or C═O;

[0043] Q7 is CR7, CR7R7′, N, NR7, NC═OR7, O, S, C═O, or a bond; and

[0044] Q8 is CR8, CR8R8′, N, NR8, NC═OR8, O, S, C═O,

[0045] Provided that at least one of Q5, Q6, Q7 (when not a bond) and Q8 must be a heteroatom selected from N, S and O and Q5, Q6, Q7 and Q8 do not form an OO, ON, OS or O=CC=O bond.

[0046] R5, R5′, R6, R6′, R7, R7′, R8 and R8′ are independently hydrogen; R21; alkenyl, alkynyl or phenyl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and 5- or 6-membered heteroaryl substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, Where n is 0, 1 or 2; or R5 and R6 together with the carbon atom to which they are attached form a 5-membered cycloalkyl group,

[0047] The premise is:

[0048] 1. R5, R5′, R6, R6′, R7, R7′, R8 and R8′ are not hydrogen at the same time;

[0049] 2. When R5, R5′, R6, R6′, R7, R7′, R8 and R8′ are independently or When , none of Q5, Q6, Q7 and Q8 is N, O or S; and

[0050] 3. When R5, R5', R6, R6', R7, R7', R8 and R8' are independently 1, 2 or 3 independently selected When the 5- or 6-membered heteroaryl group is substituted by a substituent connected to a carbon atom of the 5- or 6-membered heteroaryl group;

[0051] R9 and R10 are independently hydrogen; alkyl; alkoxyalkyl; perfluoroalkoxyalkyl; aryl, aryl optionally substituted by 1, 2 or 3 substituents independently selected from R21; 5- or 6-membered heterocyclic ring optionally substituted by 1, 2 or 3 substituents independently selected from R21; 5- or 6-membered heteroaryl optionally substituted by 1, 2 or 3 substituents independently selected from R21; or wherein n is 0, 1, 2 or 3; or

[0052] R9 and R10 together with the nitrogen atom to which they are attached form a heterocyclic ring containing 1, 2, 3 or 4 heteroatoms selected from N, O and S, which is optionally substituted with 1, 2 or 3 substituents independently selected from R11;

[0053] R11 is hydrogen; alkyl; aryl; heteroaryl containing 1 or 2 heteroatoms selected from N, O and S; arylalkyl; heteroarylalkyl, wherein the heteroaryl contains 1 or 2 heteroatoms selected from N, O and S; or

[0054] R12 is amino; alkoxy; aryl optionally substituted by 1, 2 or 3 substituents independently selected from R11; a 5- or 6-membered heterocycle having 1, 2 or 3 heteroatoms selected from N, O and S and optionally substituted by 1, 2 or 3 substituents independently selected from R11; or a 5- or 6-membered heteroaryl having 1, 2 or 3 heteroatoms selected from N, O and S and optionally substituted by 1, 2 or 3 substituents independently selected from R11;

[0055] R13 is alkyl; alkoxyalkyl; perfluoroalkoxyalkyl; aryl optionally substituted by 1, 2 or 3 substituents independently selected from R21; 5- or 6-membered heterocyclic ring optionally substituted by 1, 2 or 3 substituents independently selected from R21; 5- or 6-membered heteroaryl optionally substituted by 1, 2 or 3 substituents independently selected from R21; or wherein n is 0, 1, 2 or 3; and R14 is hydrogen or R13; or

[0056] R13 and R14 together with the nitrogen to which they are attached form a heterocyclic ring containing 1, 2 or 3 heteroatoms independently selected from N, O and S, which is optionally substituted with 1, 2 or 3 substituents independently selected from R16;

[0057] R15 is amino; alkoxy; aryl optionally substituted by 1, 2 or 3 substituents independently selected from R21; a 5- or 6-membered heterocycle having 1, 2 or 3 heteroatoms selected from N, O and S and optionally substituted by 1, 2 or 3 substituents independently selected from R21; or a 5- or 6-membered heteroaryl having 1, 2 or 3 heteroatoms selected from N, O and S and optionally substituted by 1, 2 or 3 substituents independently selected from R21;

[0058] R16 is hydrogen; alkyl; aryl; heteroaryl containing 1 or 2 heteroatoms selected from N, O and S; arylalkyl; heteroarylalkyl, wherein the heteroaryl contains 1 or 2 heteroatoms selected from N, O and S; amino; or

[0059] R17 is alkyl; alkoxyalkyl; perfluoroalkoxyalkyl; aryl optionally substituted by 1, 2 or 3 substituents independently selected from R21; 5- or 6-membered heterocyclic ring optionally substituted by 1, 2 or 3 substituents independently selected from R21; 5- or 6-membered heteroaryl optionally substituted by 1, 2 or 3 substituents independently selected from R21; or wherein n is 0, 1, 2 or 3; and R18 is hydrogen or R17; or

[0060] R17 and R18 together with the nitrogen to which they are attached form a heterocyclic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, which is optionally substituted with 1, 2 or 3 substituents independently selected from R20;

[0061] R19 is alkoxy; aryl optionally substituted by 1, 2 or 3 substituents independently selected from R21; 5- or 6-membered heterocycle optionally substituted by 1, 2 or 3 substituents independently selected from R21; or 5- or 6-membered heteroaryl optionally substituted by 1, 2 or 3 substituents independently selected from R21;

[0062] R20 is a 5- or 6-membered heterocyclic ring having 1 or 2 heteroatoms selected from N, O and S and optionally substituted by 1, 2 or 3 substituents independently selected from R21; a 5- or 6-membered heteroaryl group optionally substituted by 1, 2 or 3 substituents independently selected from R21; or R21; and

[0063] R21 is halogen, perfluoroalkyl, perfluoroalkoxy, -CN, -CONH2, -CON(CH3)2, alkyl, alkoxy, hydroxyalkyl or alkoxyalkyl,

[0064] Except for the compounds excluded from the following structural formulas (A-1), (A-2), (A-3), (A-4), (A-5), (A-6) and (A-7).

[0065] Non-limiting examples of include the following, where "X" is halogen, -CN, -CONH2, -CON(CH3)2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 hydroxyalkyl, or C1-C4 alkoxyalkyl:

[0066]

[0067]

[0068] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-1):

[0069]

[0070] Wherein R3, R4, R5 and R6 are as defined in formula (A), provided that if R3 and R4 are both hydrogen and R5 is methyl, then R6 cannot be ethyl or unsubstituted phenyl. In other embodiments, such compounds are specifically excluded from formula (A).

[0071] Formula (A-1a). Some embodiments explicitly include, and some embodiments only include, compounds of Formula (A-1) wherein R5 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) C1-C6 hydrocarbon chains containing N or O atoms and optionally substituted with C1-C3 perfluoroalkyl groups, and (2) cycloalkyl groups that may contain 1 or 2 heteroatoms selected from N, O, and S and are optionally substituted with C1-C3 perfluoroalkyl groups. In other embodiments, such compounds are explicitly excluded from Formula (A) and / or (A-1).

[0072] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein R6 is a side chain selected from the group consisting of: alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy, each optionally substituted with 1-3 substituents selected from the group consisting of: halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-1).

[0073] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein R6 is alkenyl, alkyne, phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; and

[0074] R9 and R10 are as defined with respect to Structural Formula (A).In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0075] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein R4 is hydrogen, alkoxy, or hydroxy. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-1).

[0076] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein

[0077] a. R4 is hydrogen, alkoxy or hydroxy, and

[0078] b. R5 is hydrogen, alkyl, alkoxy, alkylamino, CF3, or together with R6 and the carbon atom to which they are attached, forms a 5-membered cycloalkyl group.

[0079] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0080] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein

[0081] a. R4 is hydrogen, alkoxy or hydroxy and

[0082] b. R6 is hydrogen; alkenyl, alkyl or phenyl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and 5- or 6-membered heteroaryl substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and Where n is 0, 1 or 2; Or R5 and R6 together with the carbon atom to which they are attached form a 5-membered cycloalkyl group.

[0083] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0084] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1) wherein R5 is hydrogen, alkyl, alkoxy, alkylamino, CF3, or, together with R6 and the carbon atom to which they are attached, forms a 5-membered cycloalkyl group. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-1).

[0085] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein

[0086] a. R5 is hydrogen, alkyl, alkoxy, alkylamino, CF3, or together with R6 and the carbon atom to which they are attached, forms a 5-membered cycloalkyl group and

[0087] b. R6 is hydrogen; alkenyl, alkyl or phenyl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and 5- or 6-membered heteroaryl substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and Where n is 0, 1 or 2; Or R5 and R6 together with the carbon atom to which they are attached form a 5-membered cycloalkyl group.

[0088] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0089] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein R6 is independently hydrogen; alkenyl, alkyl, or phenyl, each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, 5- or 6-membered heteroaryl substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, Where n is 0, 1 or 2; Or R5 and R6 together with the carbon atom to which they are attached form a 5-membered cycloalkyl group.

[0090] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0091] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein

[0092] a. R4 is hydrogen, alkoxy or hydroxy,

[0093] b. R5 is hydrogen, alkyl, alkoxy, alkylamino, CF3, or together with R6 and the carbon atom to which they are attached, forms a 5-membered cycloalkyl group, and

[0094] c. R6 is hydrogen; alkenyl, alkyl or phenyl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and 5- or 6-membered heteroaryl substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and Where n is 0, 1 or 2; Or R5 and R6 together with the carbon atom to which they are attached form a 5-membered cycloalkyl group.

[0095] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0096] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein

[0097] a. R4 is hydrogen, alkoxy or hydroxy,

[0098] b. R5 is hydrogen, alkyl, alkoxy, alkylamino, CF3, or together with R6 and the carbon atom to which they are attached, forms a 5-membered cycloalkyl group, and

[0099] c. R6 is hydrogen; alkenyl, alkyl or phenyl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and

[0100] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0101] Some embodiments explicitly include, and some embodiments only include, compounds of formula (A-1), wherein

[0102] a. R4 is hydrogen, alkoxy or hydroxy,

[0103] b. R5 is hydrogen, alkyl, alkoxy, alkylamino, CF3, or together with R6 and the carbon atom to which they are attached, forms a 5-membered cycloalkyl group, and

[0104] c. R6 is a 5- or 6-membered heteroaryl substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and

[0105] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0106] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein

[0107] a. R4 is hydrogen, alkoxy or hydroxy,

[0108] b. R5 is hydrogen, alkyl, alkoxy, alkylamino, CF3, or together with R6 and the carbon atom to which they are attached, forms a 5-membered cycloalkyl group, and

[0109] c.R6 is

[0110] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0111] Some embodiments explicitly include, and some embodiments only include, compounds of formula (A-1), wherein

[0112] a. R4 is hydrogen,

[0113] b. R5 is hydrogen, alkyl, alkoxy, alkylamino, CF3, or together with R6 and the carbon atom to which they are attached, forms a 5-membered cycloalkyl group, and

[0114] c. R6 is hydrogen; alkenyl, alkyl or phenyl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and 5- or 6-membered heteroaryl substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and Where n is 0, 1 or 2; Or R5 and R6 together with the carbon atom to which they are attached form a 5-membered cycloalkyl group.

[0115] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0116] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein

[0117] a. R4 is an alkoxy group,

[0118] b. R5 is hydrogen, alkyl, alkoxy, alkylamino, CF3, or together with R6 and the carbon atom to which they are attached, forms a 5-membered cycloalkyl group, and

[0119] c. R6 is hydrogen; alkenyl, alkyl or phenyl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and 5- or 6-membered heteroaryl substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and Where n is 0, 1 or 2; Or R5 and R6 together with the carbon atom to which they are attached form a 5-membered cycloalkyl group.

[0120] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0121] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein

[0122] a. R4 is a hydroxyl group,

[0123] b. R5 is hydrogen, alkyl, alkoxy, alkylamino, CF3, or together with R6 and the carbon atom to which they are attached, forms a 5-membered cycloalkyl group, and

[0124] c. R6 is hydrogen; alkenyl, alkyl or phenyl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and 5- or 6-membered heteroaryl substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and Where n is 0, 1 or 2; Or R5 and R6 together with the carbon atom to which they are attached form a 5-membered cycloalkyl group.

[0125] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0126] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-1), wherein

[0127] a. R4 is hydrogen, alkoxy or hydroxy,

[0128] b. R5 is hydrogen, alkyl, alkoxy, alkylamino or CF3, and

[0129] c. R6 is hydrogen; alkenyl, alkyl or phenyl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and 5- or 6-membered heteroaryl substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, perfluoroalkoxy, and Where n is 0, 1 or 2; Or R5 and R6 together with the carbon atom to which they are attached form a 5-membered cycloalkyl group.

[0130] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-1).

[0131] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-1a) and (2) compounds of any of formulas (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-1).

[0132] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-1a) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-1).

[0133] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1a) and (2) compounds of any of formulas (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0134] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1a) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-11), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0135] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1b) and (2) compounds of any of formulas (A-1a), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0136] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1b) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-11), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formulae (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0137] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1c) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0138] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1c) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-11), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formulae (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0139] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1d) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0140] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1d) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1c), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-11), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formulae (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0141] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1e) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0142] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1e) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1c), (A-1d), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-11), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0143] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1f) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0144] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1f) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-11), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formulae (A) and / or (A-1). Every possible combination is expressly contemplated as if expressly listed herein.

[0145] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1g) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0146] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1g) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1h), (A-1i), (A-1j), (A-1k), (A-11), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0147] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1h) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0148] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1h) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1i), (A-1j), (A-1k), (A-11), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formulae (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0149] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1i) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0150] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1i) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1j), (A-1k), (A-11), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0151] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1j) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0152] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1j) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0153] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1k) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0154] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1k) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1l), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formulae (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0155] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-11) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0156] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-11) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1m), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0157] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1m) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0158] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1m) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1n), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formulae (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0159] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1n) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0160] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1n) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1o), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0161] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1o) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0162] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1o) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1p), and (A-1q). In other embodiments, such compounds are explicitly excluded from formulae (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0163] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1p) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0164] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1p) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-11), (A-1m), (A-1n), (A-1o), and (A-1q). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0165] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1q) and (2) compounds of any of formulas (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-1l), (A-1m), (A-1n), (A-1o), and (A-1p). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0166] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-1q) and (2) compounds of up to 16 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16) of formulae (A-1a), (A-1b), (A-1c), (A-1d), (A-1e), (A-1f), (A-1g), (A-1h), (A-1i), (A-1j), (A-1k), (A-11), (A-1m), (A-1n), (A-1o), and (A-1p). In other embodiments, such compounds are explicitly excluded from formulae (A) and / or (A-1). Every possible combination is expressly contemplated, as if expressly listed herein.

[0167] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-2):

[0168]

[0169] wherein R3, R4, R5, R5', R6, R7, R7', R8 and R8' are as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[0170] Structural Formula (A-2a). Some embodiments specifically include, and some embodiments only include, compounds of Structural Formula (A-2), wherein R3, R4, R5, R5', R7, R7', R8, and R8' are hydrogen. In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-2).

[0171] 87 Structural Formula (A-2b). Some embodiments specifically include, and some embodiments only include, compounds of Structural Formula (A-2), wherein R6 is a side chain selected from the group consisting of: alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy, each optionally substituted with 1-3 substituents selected from the group consisting of: halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy. In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-2).

[0172] Structural Formula (A-2c). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-2), wherein R7′ is hydrogen and R7 is a side chain selected from the group consisting of: alkyl, perfluoroalkylalkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy, each optionally substituted with 1-3 substituents selected from the group consisting of: halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-2).

[0173] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-2), wherein R6 is alkenyl, alkyne, phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; and

[0174] R9 and R10 are as defined with respect to structural formula (A).

[0175] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-2).

[0176] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-2a) and (2) compounds of any of formulas (A-2b), (A-2c), and (A-2d). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-2). Every possible combination is expressly contemplated as if expressly listed herein.

[0177] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-2a) and (2) compounds of up to three (e.g., 1, 2, or 3) of formulas (A-2b), (A-2c), and (A-2d). In other embodiments, such compounds are explicitly excluded from formulas (A) and / or (A-2). Every possible combination is expressly contemplated as if expressly listed herein.

[0178] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-2b) and (2) compounds of any of formulas (A-2a), (A-2c), and (A-2d). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-2). Every possible combination is expressly contemplated as if expressly listed herein.

[0179] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-2b) and (2) compounds of up to three (e.g., 1, 2, or 3) of formulas (A-2a), (A-2c), and (A-2d). In other embodiments, such compounds are explicitly excluded from formulas (A) and / or (A-2). Every possible combination is expressly contemplated as if expressly listed herein.

[0180] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-2c) and (2) compounds of any of formulas (A-2a), (A-2b), and (A-2d). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-2). Every possible combination is expressly contemplated as if expressly listed herein.

[0181] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-2c) and (2) compounds of up to three (e.g., 1, 2, or 3) of formulas (A-2a), (A-2b), and (A-2d). In other embodiments, such compounds are explicitly excluded from formulas (A) and / or (A-2). Every possible combination is expressly contemplated as if expressly listed herein.

[0182] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-2d) and (2) compounds of any of formulas (A-2a), (A-2b), and (A-2c). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-2). Every possible combination is expressly contemplated as if expressly listed herein.

[0183] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-2d) and (2) compounds of up to three (e.g., 1, 2, or 3) of formulas (A-2a), (A-2b), and (A-2c). In other embodiments, such compounds are explicitly excluded from formulas (A) and / or (A-2). Every possible combination is expressly contemplated as if expressly listed herein.

[0184] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-3):

[0185]

[0186] in:

[0187] R3, R4, R6 and R7 are as defined in formula (A), with the proviso that:

[0188] i. If R3 and R4 are hydrogen and R6 is optionally substituted phenyl, then R7 cannot be optionally substituted phenyl, hydrogen, methyl or CH2O(CH2)2;

[0189] ii. If R3 and R4 are hydrogen and R6 is methoxy, then R7 is not methyl or unsubstituted phenyl;

[0190] iii. If R3 is ethyl, R4 is hydrogen, and R7 is methyl, then R6 is not fluorophenyl;

[0191] iv. If R3 is halogen and R4 and R7 are hydrogen, then R6 is not phenyl; and

[0192] v. If any of the following circumstances occurs:

[0193] i. R3 is halogen and R4 is hydrogen; or

[0194] ii. one of R3 and R4 is methyl and the other is hydrogen,

[0195] Then R6 and R7 cannot both be methyl groups.

[0196] In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[0197] Structural Formula (A-3a). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-3), wherein R6 is a side chain selected from the group consisting of: alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, C1-C6 alkoxyalkyl, and perfluoroalkoxy, each optionally substituted with 1-3 substituents selected from the group consisting of: halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-3).

[0198] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein R6 is alkenyl, or alkynyl, or phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; wherein R9 and R10 are as defined in formula (A). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3).

[0199] Structural Formula (A-3c). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-3), wherein R7 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) C1-C6 hydrocarbon chains containing N or O atoms and optionally substituted with C1-C3 perfluoroalkyl groups, and (2) cycloalkyl groups that may contain 1 or 2 heteroatoms selected from N, O, and S and are optionally substituted with C1-C3 perfluoroalkyl groups. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-3).

[0200] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein R9 and R10 are independently hydrogen, C2-C6 alkyl, alkoxyalkyl, perfluoroalkoxyalkyl, aryl, optionally substituted with 1, 2, or 3 substituents independently selected from R21. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3).

[0201] Structural Formula (A-3e). Some embodiments specifically include, and some embodiments only include, compounds of Structural Formula (A-3), wherein R9 and R10 are independently a 5- or 6-membered heterocycle optionally substituted with 1, 2, or 3 substituents independently selected from R21. In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0202] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein R9 and R10 are independently 5- or 6-membered heteroaryl optionally substituted with 1, 2, or 3 substituents independently selected from R21; or wherein n is 0, 1, 2 or 3 and R12 is as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0203] Structural Formula (A-3g). Some embodiments specifically include, and some embodiments only include, compounds of Structural Formula (A-3), wherein R9 and R10, together with the nitrogen atom to which they are attached, form a heterocyclic ring containing 1, 2, 3, or 4 heteroatoms selected from N, O, and S, which is optionally substituted with 1, 2, or 3 substituents independently selected from R11, wherein R11 is as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0204] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein R6 is alkenyl, or alkynyl, or phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; wherein R9 and R10 are as defined in formula (A). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3).

[0205] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein R7 is alkyl. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3).

[0206] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein R7 is methyl. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3).

[0207] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0208] a. R7 is an alkyl group.

[0209] b. R6 is alkenyl, or alkynyl, or phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; wherein R9 and R10 are as defined in formula (A).

[0210] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0211] Some embodiments specifically include, and some embodiments only include, compounds of formula (A3) wherein R3 is alkoxy. Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3) wherein R3 is methoxy. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3).

[0212] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0213] a. R7 is methyl and

[0214] b. R3 is an alkoxy group.

[0215] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0216] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0217] a. R7 is methyl;

[0218] b. R3 is alkoxy; and

[0219] c. R6 is alkenyl, or alkynyl, or phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; wherein R9 and R10 are as defined in formula (A).

[0220] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0221] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0222] a. R7 is methyl and

[0223] b. R3 is methoxy.

[0224] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0225] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0226] a. R7 is methyl;

[0227] b. R3 is methoxy; and

[0228] c. R6 is alkenyl, or alkynyl, or phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; wherein R9 and R10 are as defined in formula (A).

[0229] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0230] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0231] a. R7 is an alkyl group and

[0232] b. R3 is an alkoxy group.

[0233] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0234] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0235] a. R7 is an alkyl group,

[0236] b. R3 is an alkoxy group, and

[0237] c. R6 is alkenyl, or alkynyl, or phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; wherein R9 and R10 are as defined in formula (A).

[0238] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0239] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein R6 is wherein n is 0, 1 or 2, and R9 and R10 are as defined in formula (A).

[0240] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0241] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein R3 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3).

[0242] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein R4 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3).

[0243] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3).

[0244] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0245] a. R3 is methoxy and

[0246] b. R4 is hydrogen.

[0247] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0248] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0249] a. R3 is methoxy,

[0250] b. R4 is hydrogen, and

[0251] c. R7 is methyl.

[0252] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0253] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0254] a. R4 is methoxy and

[0255] b. R7 is methyl.

[0256] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0257] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0258] a. R3 is hydrogen and

[0259] b. R6 is alkenyl, or alkynyl, or phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; wherein R9 and R10 are as defined in formula (A).

[0260] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0261] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0262] a. R4 is hydrogen and

[0263] b. R6 is alkenyl, or alkynyl, or phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; wherein R9 and R10 are as defined in formula (A).

[0264] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0265] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0266] a. R3 and R4 are hydrogen and

[0267] b. R6 is alkenyl, or alkynyl, or phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; wherein R9 and R10 are as defined in formula (A).

[0268] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0269] Some embodiments explicitly include, and some embodiments only include, compounds of formula (A-3), wherein

[0270] a. R3 is methoxy,

[0271] b. R4 is hydrogen, and

[0272] c. R6 is alkenyl, or alkynyl, or phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; wherein R9 and R10 are as defined in formula (A).

[0273] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0274] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0275] a. R3 is methoxy,

[0276] b. R4 is hydrogen,

[0277] c. R7 is methyl, and

[0278] d. R6 is alkenyl, or alkynyl, or phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; wherein R9 and R10 are as defined in formula (A).

[0279] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0280] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-3), wherein

[0281] a. R4 is methoxy,

[0282] b. R7 is methyl, and

[0283] c. R6 is alkenyl, or alkynyl, or phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; wherein R9 and R10 are as defined in formula (A).

[0284] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-3).

[0285] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3a) and (2) compounds of any one of formulas (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0286] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3a) and (2) compounds of formula (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s ...s), (A-3t), (A-3 In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0287] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3b) and (2) compounds of any one of formulas (A-3a), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0288] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3b) and (2) compounds of formula (A-3a), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s ... In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0289] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3c) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0290] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3c) and (2) compounds of formula (A-3a), (A-3b), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3j ...s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3j), (A-3j), (A-3 In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0291] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3d) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0292] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3d) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i ...n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3j), (A-3j), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3j), (A-3j), (A-3 In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0293] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3e) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0294] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3e) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s ... In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0295] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3f) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0296] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3f) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i ...n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3j), (A-3j), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3j), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3s), (A-3 In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0297] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3g) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0298] Some embodiments explicitly include and some embodiments include only (1) compounds of formula (A-3g) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i ...j), (A-3j), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3 In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0299] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3h) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0300] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3h) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3j ...i), (A-3i), (A-3j), (A-3k), (A-3i), (A-3j), (A-3j), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3s), (A-3t), (A-3i), (A-3i), (A-3i), (A-3j), (A-3j), (A-3k), (A-3i), (A-3i), (A-3i), (A-3i), (A-3i), (A-3i), (A-3i), (A-3i), (A-3i), (A-3i), (A-3i), (A-3i), ( In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0301] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3i) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0302] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3i) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t ...s), (A-3t), (A-3h), (A-3j), (A-3j), (A-3j), (A-3 In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0303] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3j) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0304] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3j) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3k), (A-3i ...s), (A-3t), (A-3 In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0305] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3k) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0306] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3k) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3i ...j), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3s), (A-3t), (A-3n), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3s), (A-3s), (A-3t), (A-3 In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0307] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-31) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0308] Some embodiments explicitly include and some embodiments include only (1) compounds of formula (A-31) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t ...s), (A-3t), (A-3 In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0309] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3m) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0310] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3m) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3t), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s ... In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0311] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3n) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0312] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3n) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i ...s), (A-3t), (A-3 In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0313] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3o) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0314] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3o) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i ... In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0315] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3p) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0316] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3p) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3q), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i ...n), (A-3o), (A-3q), (A-3r), (A-3s), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3q), (A-3r), (A-3s), (A-3s), (A-3t), (A-3 In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0317] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3q) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0318] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3q) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3r), (A-3s), (A-3t), (A-3n), (A-3o), (A-3p), (A-3r), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3n), (A-3o), (A-3p), (A-3r), (A-3s), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3j), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3r), (A-3s), (A-3s), (A-3t), (A-3 In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0319] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3r) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0320] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3r) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3s), (A-3t), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i ... In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0321] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3s) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0322] Some embodiments explicitly include and some embodiments only include (1) compounds of formula (A-3s) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x ... In some embodiments, the present invention further comprises compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulae selected from the group consisting of Structural Formulas (A), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0323] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3t) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0324] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3t) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s ...i), (A-3j), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), ( In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0325] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3u) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0326] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3u) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3s), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i ...j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (

[0015] In some embodiments, the present invention provides compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3t), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0327] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3v) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0328] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3v) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i ...j), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), ( In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3t), (A-3u), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0329] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3w) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0330] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3w) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3s), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r ...i), (A-3j), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), ( In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3t), (A-3u), (A-3v), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0331] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3x) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0332] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3x) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3s), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i), (A-3j), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3d), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), ( In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3t), (A-3u), (A-3v), (A-3w), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0333] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3y) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0334] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3y) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3i ...j), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), ( In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3z), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0335] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3z) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0336] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3z) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s ...i), (A-3j), (A-3j), (A-3k), (A-3i), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3d), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), ( In some embodiments, the present invention relates to compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) formulas selected from the group consisting of Structural Formulas (A), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3aa), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from Structural Formulas (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0337] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3aa) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3bb), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0338] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3aa) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s),

[0015] Compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) of formula (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3bb), (A-3cc), (A-3dd), and (A-3ee) are also contemplated. In other embodiments, such compounds are specifically excluded from structural formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0339] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3bb) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3cc), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0340] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3bb) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s),

[0015] Compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) of formula (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3cc), (A-3dd), and (A-3ee) are also contemplated. In other embodiments, such compounds are specifically excluded from structural formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0341] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3cc) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3dd), and (A-3ee). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0342] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3cc) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s),

[0015] Compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) of formula (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3dd), and (A-3ee) are also contemplated. In other embodiments, such compounds are specifically excluded from structural formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0343] Some embodiments explicitly include and some embodiments include only (1) compounds of formula (A-3dd) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), Compounds of any of the formulas (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), and (A-3ee). In other embodiments, such compounds are explicitly excluded from structural formula (A) and / or (A-3). Every possible combination is expressly contemplated, as if expressly listed herein.

[0344] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3dd) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s),

[0015] Compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) of formula (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), and (A-3ee) are also contemplated. In other embodiments, such compounds are specifically excluded from structural formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0345] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-3ee) and (2) compounds of any one of formulas (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s), (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), and (A-3dd). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0346] Some embodiments explicitly include, and some embodiments include only, (1) compounds of formula (A-3ee) and (2) compounds of formula (A-3a), (A-3b), (A-3c), (A-3d), (A-3e), (A-3f), (A-3g), (A-3h), (A-3i), (A-3j), (A-3k), (A-3l), (A-3m), (A-3n), (A-3o), (A-3p), (A-3q), (A-3r), (A-3s),

[0015] Compounds of up to 30 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) of formula (A-3t), (A-3u), (A-3v), (A-3w), (A-3x), (A-3y), (A-3z), (A-3aa), (A-3bb), (A-3cc), and (A-3dd) are also contemplated. In other embodiments, such compounds are specifically excluded from structural formula (A) and / or (A-3). Every possible combination is expressly contemplated as if expressly listed herein.

[0347] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-4):

[0348]

[0349] wherein R3, R4, R5, R5', R6, R6', R7, R8 and R8' are as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[0350] Structural Formula (A-4a). Some embodiments specifically include, and some embodiments only include, compounds of Structural Formula (A-4), wherein R3, R4, R5, R5', R6, R6', R8, and R8' are hydrogen. In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-4).

[0351] Formula (A-4b). Some embodiments explicitly include, and some embodiments only include, compounds of Formula (A-4), wherein R7 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) C1-C6 hydrocarbon chains containing nitrogen or oxygen atoms and optionally substituted with C1-C3 perfluoroalkyl groups, and (2) cycloalkyl groups that may contain 1 or 2 heteroatoms selected from N, O, and S and are optionally substituted with C1-C3 perfluoroalkyl groups. In other embodiments, such compounds are explicitly excluded from Formula (A) and / or (A-4).

[0352] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-4), wherein R7 is alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, or perfluoroalkoxy. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-4).

[0353] Structural Formula (A-4d). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-4), wherein R7 is a side chain selected from the group consisting of: alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy, each optionally substituted with 1-3 substituents selected from the group consisting of: halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-4).

[0354] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-4), wherein R is alkenyl, alkyne, phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; and

[0355] R9 and R10 are as defined with respect to Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-4).

[0356] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-4a) and (2) compounds of any of formulas (A-4b), (A-4c), (A-4d), and (A-4e). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-4). Every possible combination is expressly contemplated as if expressly listed herein.

[0357] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-4a) and (2) compounds of up to four (e.g., 1, 2, 3, or 4) of formulas (A-4b), (A-4c), (A-4d), and (A-4e). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-4). Every possible combination is expressly contemplated as if expressly listed herein.

[0358] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-4b) and (2) compounds of any of formulas (A-4a), (A-4c), (A-4d), and (A-4e). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-4). Every possible combination is expressly contemplated as if expressly listed herein.

[0359] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-4b) and (2) compounds of up to four (e.g., 1, 2, 3, or 4) of formulas (A-4a), (A-4c), (A-4d), and (A-4e). In other embodiments, such compounds are explicitly excluded from formulas (A) and / or (A-4). Every possible combination is expressly contemplated, as if expressly listed herein.

[0360] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-4c) and (2) compounds of any of formulas (A-4a), (A-4b), (A-4d), and (A-4e). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-4). Every possible combination is expressly contemplated as if expressly listed herein.

[0361] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-4c) and (2) compounds of up to four (e.g., 1, 2, 3, or 4) of formulas (A-4a), (A-4b), (A-4d), and (A-4e). In other embodiments, such compounds are explicitly excluded from formulas (A) and / or (A-4). Every possible combination is expressly contemplated, as if expressly listed herein.

[0362] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-4d) and (2) compounds of any of formulas (A-4a), (A-4b), (A-4c), and (A-4e). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-4). Every possible combination is expressly contemplated as if expressly listed herein.

[0363] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-4d) and (2) compounds of up to four (e.g., 1, 2, 3, or 4) of formulas (A-4a), (A-4b), (A-4c), and (A-4e). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-4). Every possible combination is expressly contemplated as if expressly listed herein.

[0364] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-4e) and (2) compounds of any of formulas (A-4a), (A-4b), (A-4c), and (A-4d). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-4). Every possible combination is expressly contemplated as if expressly listed herein.

[0365] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-4e) and (2) compounds of up to four (e.g., 1, 2, 3, or 4) of formulas (A-4a), (A-4b), (A-4c), and (A-4d). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-4). Every possible combination is expressly contemplated as if expressly listed herein.

[0366] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-5):

[0367]

[0368] wherein R3, R4, R6, R7 and R8 are as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[0369] Structural Formula (A-5a). Some embodiments include only those compounds of Structural Formula (A-5) in which R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-5).

[0370] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-5), wherein R6 is alkenyl, alkyne, phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; and

[0371] R9 and R10 are as defined with respect to Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-5).

[0372] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-5a) and (2) compounds of formula (A-5b). In other embodiments, compounds of formula (1) (A-5a) and (2) (A-5b) are explicitly excluded from formula (A) and / or (A-5).

[0373] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-6a):

[0374]

[0375] in:

[0376] R3, R4 and R6 are as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[0377] Structural Formula (A-6a1). Some embodiments include only those compounds of Structural Formula (A-6a) wherein R3 is hydrogen. In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6a).

[0378] Structural Formula (A-6a2). Some embodiments include only those compounds of Structural Formula (A-6a) wherein R4 is hydrogen. In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6a).

[0379] Structural Formula (A-6a3). Some embodiments include only those compounds of Structural Formula (A-6a) wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6a).

[0380] Structural Formula (A-6a4). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-6a), wherein R6 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) C1-C6 hydrocarbon chains containing nitrogen or oxygen atoms and optionally substituted with C1-C3 perfluoroalkyl groups, and (2) cycloalkyl groups that may contain 1 or 2 heteroatoms selected from N, O, and S and are optionally substituted with C1-C3 perfluoroalkyl groups. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-6a).

[0381] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-6a), wherein R is C1-C6 alkyl, C1-C6 perfluoroalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 alkoxyalkyl, or C1-C6 perfluoroalkoxy. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-6a).

[0382] Some embodiments include only those compounds of formula (A-6a), wherein

[0383] a. R3 is hydrogen and

[0384] b. R6 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) a C1-C6 hydrocarbon chain containing nitrogen or oxygen atoms and optionally substituted with a C1-C3 perfluoroalkyl group, and (2) a cycloalkyl group which may contain 1 or 2 heteroatoms selected from N, O, and S and is optionally substituted with a C1-C3 perfluoroalkyl group.

[0385] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6a).

[0386] Some embodiments include only those compounds of formula (A-6a), wherein

[0387] a. R4 is hydrogen and

[0388] b. R6 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) a C1-C6 hydrocarbon chain containing nitrogen or oxygen atoms and optionally substituted with a C1-C3 perfluoroalkyl group, and (2) a cycloalkyl group which may contain 1 or 2 heteroatoms selected from N, O, and S and is optionally substituted with a C1-C3 perfluoroalkyl group.

[0389] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6a).

[0390] Some embodiments include only those compounds of formula (A-6a), wherein

[0391] a. R3 and R4 are hydrogen and

[0392] b. R6 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) a C1-C6 hydrocarbon chain containing nitrogen or oxygen atoms and optionally substituted with a C1-C3 perfluoroalkyl group, and (2) a cycloalkyl group which may contain 1 or 2 heteroatoms selected from N, O, and S and is optionally substituted with a C1-C3 perfluoroalkyl group.

[0393] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6a).

[0394] Some embodiments include only those compounds of formula (A-6a), wherein

[0395] a. R3 is hydrogen and

[0396] b. R6 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 alkoxyalkyl or C1-C6 perfluoroalkoxy.

[0397] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6a).

[0398] Some embodiments include only those compounds of formula (A-6a), wherein

[0399] a. R4 is hydrogen and

[0400] b. R6 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 alkoxyalkyl or C1-C6 perfluoroalkoxy.

[0401] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6a).

[0402] Some embodiments include only those compounds of formula (A-6a) wherein

[0403] a. R3 and R4 are hydrogen and

[0404] b. R6 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 alkoxyalkyl or C1-C6 perfluoroalkoxy.

[0405] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6a).

[0406] Structural Formula (A-6a12). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-6a), wherein R6 is a side chain selected from the group consisting of: alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy, each optionally substituted with 1-3 substituents selected from the group consisting of: halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-6a).

[0407] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-6a), wherein R6 is alkenyl, alkyne, phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; and

[0408] R9 and R10 are as defined with respect to Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6a).

[0409] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a1) and (2) compounds of any of formulas (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0410] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a1) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0411] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a2) and (2) compounds of any of formulas (A-6a1), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0412] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a2) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a1), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly listed herein.

[0413] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a3) and (2) compounds of any of formulas (A-6a1), (A-6a2), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0414] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a3) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a1), (A-6a2), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly listed herein.

[0415] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a4) and (2) compounds of any of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0416] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a4) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly listed herein.

[0417] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a5) and (2) compounds of any of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0418] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a5) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0419] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a6) and (2) compounds of any of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0420] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a6) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly listed herein.

[0421] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a7) and (2) compounds of any of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0422] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a7) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a8), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly listed herein.

[0423] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a8) and (2) compounds of any of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0424] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a8) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a9), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly listed herein.

[0425] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a9) and (2) compounds of any of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0426] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a9) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a10), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly listed herein.

[0427] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a10) and (2) compounds of any of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly listed herein.

[0428] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a10) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a11), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly listed herein.

[0429] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a11) and (2) compounds of any of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0430] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a11) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a12), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly listed herein.

[0431] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a12) and (2) compounds of any of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0432] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a12) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), and (A-6a13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly listed herein.

[0433] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a13) and (2) compounds of any of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), and (A-6a12). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0434] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6a13) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6a1), (A-6a2), (A-6a3), (A-6a4), (A-6a5), (A-6a6), (A-6a7), (A-6a8), (A-6a9), (A-6a10), (A-6a11), and (A-6a12). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6a). Every possible combination is expressly contemplated as if expressly listed herein.

[0435] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-6b):

[0436]

[0437] in:

[0438] R3, R4 and R6 are as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[0439] Structural Formula (A-6b1). Some embodiments include only those compounds of Structural Formula (A-6b) wherein R3 is hydrogen. In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6b).

[0440] Structural Formula (A-6b2). Some embodiments include only those compounds of Structural Formula (A-6b) wherein R4 is hydrogen. In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6b).

[0441] Structural Formula (A-6b3). Some embodiments include only those compounds of Structural Formula (A-6b) wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6b).

[0442] Structural Formula (A-6b4). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-6b), wherein R6 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) C1-C6 hydrocarbon chains containing nitrogen or oxygen atoms and optionally substituted with C1-C3 perfluoroalkyl groups, and (2) cycloalkyl groups that may contain 1 or 2 heteroatoms selected from N, O, and S and are optionally substituted with C1-C3 perfluoroalkyl groups. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-6b).

[0443] Formula (A-6b5). Some embodiments specifically include, and some embodiments only include, compounds of Formula (A-6b) wherein R6 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 alkoxyalkyl, or C1-C6 perfluoroalkoxy. In other embodiments, such compounds are specifically excluded from Formula (A) and / or (A-6b).

[0444] Some embodiments include only those compounds of formula (A-6b), wherein

[0445] a. R3 is hydrogen and

[0446] b. R6 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) a C1-C6 hydrocarbon chain containing nitrogen or oxygen atoms and optionally substituted with a C1-C3 perfluoroalkyl group, and (2) a cycloalkyl group which may contain 1 or 2 heteroatoms selected from N, O, and S and is optionally substituted with a C1-C3 perfluoroalkyl group.

[0447] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6b).

[0448] Some embodiments include only those compounds of formula (A-6b), wherein

[0449] a. R4 is hydrogen and

[0450] b. R6 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) a C1-C6 hydrocarbon chain containing nitrogen or oxygen atoms and optionally substituted with a C1-C3 perfluoroalkyl group, and (2) a cycloalkyl group which may contain 1 or 2 heteroatoms selected from N, O, and S and is optionally substituted with a C1-C3 perfluoroalkyl group.

[0451] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6b).

[0452] Some embodiments include only those compounds of formula (A-6b), wherein

[0453] a. R3 and R4 are hydrogen and

[0454] b. R6 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) a C1-C6 hydrocarbon chain containing nitrogen or oxygen atoms and optionally substituted with a C1-C3 perfluoroalkyl group, and (2) a cycloalkyl group which may contain 1 or 2 heteroatoms selected from N, O, and S and is optionally substituted with a C1-C3 perfluoroalkyl group.

[0455] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6b).

[0456] Some embodiments include only those compounds of formula (A-6b), wherein

[0457] a. R3 is hydrogen and

[0458] b. R6 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 alkoxyalkyl or C1-C6 perfluoroalkoxy.

[0459] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6b).

[0460] Some embodiments include only those compounds of formula (A-6b), wherein

[0461] a. R4 is hydrogen and

[0462] b. R6 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 alkoxyalkyl or C1-C6 perfluoroalkoxy.

[0463] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6b).

[0464] Some embodiments include only those compounds of formula (A-6b), wherein

[0465] a. R3 and R4 are hydrogen and

[0466] b. R6 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 alkoxyalkyl or C1-C6 perfluoroalkoxy.

[0467] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6b).

[0468] Structural Formula (A-6b12). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-6b), wherein R6 is a side chain selected from the group consisting of: alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy, each optionally substituted with 1-3 substituents selected from the group consisting of: halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-6b).

[0469] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-6b), wherein R6 is alkenyl, alkyne, phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; and

[0470] R9 and R10 are as defined with respect to Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-6b).

[0471] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b1) and (2) compounds of any of formulas (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0472] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b1) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0473] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b2) and (2) compounds of any of formulas (A-6b1), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0474] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b2) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b1), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0475] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b3) and (2) compounds of any of formulas (A-6b1), (A-6b2), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0476] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b3) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b1), (A-6b2), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0477] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b4) and (2) compounds of any of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0478] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b4) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0479] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-6b5) and (2) compounds of any one of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0480] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b5) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0481] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b6) and (2) compounds of any of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0482] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b6) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0483] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b7) and (2) compounds of any of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0484] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b7) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b8), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0485] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b8) and (2) compounds of any of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0486] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b8) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b9), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0487] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b9) and (2) compounds of any of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0488] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b9) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b10), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0489] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b10) and (2) compounds of any of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0490] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b10) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b11), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0491] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b11) and (2) compounds of any of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0492] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b11) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b12), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0493] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b12) and (2) compounds of any of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0494] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b12) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), and (A-6b13). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0495] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b13) and (2) compounds of any of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), and (A-6b12). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0496] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b13) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12) of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), and (A-6b12). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0497] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-6b13) and (2) compounds of any of formulas (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), or (A-6b12). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0498] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-6b13) and (2) compounds of up to 12 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30) of formula (A-6b1), (A-6b2), (A-6b3), (A-6b4), (A-6b5), (A-6b6), (A-6b7), (A-6b8), (A-6b9), (A-6b10), (A-6b11), or (A-6b12). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-6b). Every possible combination is expressly contemplated as if expressly listed herein.

[0499] Some embodiments expressly include, and some embodiments include only, compounds having structural formula (A-7a), which may exist as a mixture of two tautomers:

[0500]

[0501] wherein R3, R4 and R6 are as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[0502] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7a), wherein R3 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7a).

[0503] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7a), wherein R4 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7a).

[0504] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7a) wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7a).

[0505] Structural Formula (A-7a4). Some embodiments include only those compounds of Structural Formula (A-7a) wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7a).

[0506] Structural Formula (A-7a5). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-7a), wherein R6 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) C1-C6 hydrocarbon chains containing nitrogen or oxygen atoms and optionally substituted with C1-C3 perfluoroalkyl groups, and (2) cycloalkyl groups that may contain 1 or 2 heteroatoms selected from N, O, and S and are optionally substituted with C1-C3 perfluoroalkyl groups. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-7a).

[0507] Structural Formula (A-7a6). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-7a), wherein R6 is a side chain selected from the group consisting of: alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy, each optionally substituted with 1-3 substituents selected from the group consisting of: halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-7a).

[0508] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7a), wherein R is alkenyl, alkyne, phenyl, or a 5- or 6-membered heteroaryl, each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; and

[0509] R9 and R10 are as defined with respect to structural formula (A).

[0510] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7a).

[0511] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a1) and (2) compounds of any of formulas (A-7a2), (A-7a3), (A-7a4), (A-7a5), (A-7a6), and (A-7a7). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated as if expressly listed herein.

[0512] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a1) and (2) compounds of up to six (e.g., 1, 2, 3, 4, 5, or 6) of formulas (A-7a2), (A-7a3), (A-7a4), (A-7a5), (A-7a6), and (A-7a7). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0513] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a2) and (2) compounds of any of formulas (A-7a1), (A-7a3), (A-7a4), (A-7a5), (A-7a6), and (A-7a7). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0514] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a2) and (2) compounds of up to six (e.g., 1, 2, 3, 4, 5, or 6) of formulas (A-7a1), (A-7a3), (A-7a4), (A-7a5), (A-7a6), and (A-7a7). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0515] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a3) and (2) compounds of any of formulas (A-7a1), (A-7a2), (A-7a4), (A-7a5), (A-7a6), and (A-7a7). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0516] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a3) and (2) compounds of up to six (e.g., 1, 2, 3, 4, 5, or 6) of formulas (A-7a1), (A-7a2), (A-7a4), (A-7a5), (A-7a6), and (A-7a7). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated as if expressly listed herein.

[0517] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a4) and (2) compounds of any of formulas (A-7a1), (A-7a2), (A-7a3), (A-7a5), (A-7a6), and (A-7a7). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0518] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a4) and (2) compounds of up to six (e.g., 1, 2, 3, 4, 5, or 6) of formulas (A-7a1), (A-7a2), (A-7a3), (A-7a5), (A-7a6), and (A-7a7). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0519] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a5) and (2) compounds of any of formulas (A-7a1), (A-7a2), (A-7a3), (A-7a4), (A-7a6), and (A-7a7). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0520] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a5) and (2) compounds of up to six (e.g., 1, 2, 3, 4, 5, or 6) of formulas (A-7a1), (A-7a2), (A-7a3), (A-7a4), (A-7a6), and (A-7a7). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0521] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a6) and (2) compounds of any of formulas (A-7a1), (A-7a2), (A-7a3), (A-7a4), (A-7a5), and (A-7a7). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0522] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a6) and (2) compounds of up to six (e.g., 1, 2, 3, 4, 5, or 6) of formulas (A-7a1), (A-7a2), (A-7a3), (A-7a4), (A-7a5), and (A-7a7). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated as if expressly listed herein.

[0523] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a7) and (2) compounds of any of formulas (A-7a1), (A-7a2), (A-7a3), (A-7a4), (A-7a5), and (A-7a6). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0524] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7a7) and (2) compounds of up to six (e.g., 1, 2, 3, 4, 5, or 6) of formulas (A-7a1), (A-7a2), (A-7a3), (A-7a4), (A-7a5), and (A-7a6). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7a). Every possible combination is expressly contemplated as if expressly listed herein.

[0525] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-7b):

[0526]

[0527] wherein R3, R4 and R6 are as defined in formula (A) and R7 is hydrogen or C1-C3 alkyl. In other embodiments, such compounds are specifically excluded from formula (A).

[0528] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b) wherein R3 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b).

[0529] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b) wherein R4 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b).

[0530] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b) wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b).

[0531] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b) wherein R7 is C1-C3 alkyl. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b).

[0532] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b) wherein R7 is methyl. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b).

[0533] Structural Formula (A-7b6). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-7b), wherein R6 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) C1-C6 hydrocarbon chains containing nitrogen or oxygen atoms and optionally substituted with C1-C3 perfluoroalkyl groups, and (2) cycloalkyl groups that may contain 1 or 2 heteroatoms selected from N, O, and S and are optionally substituted with C1-C3 perfluoroalkyl groups. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-7b).

[0534] Structural Formula (A-7b7). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-7b), wherein R6 is a side chain selected from the group consisting of: alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy, each optionally substituted with 1-3 substituents selected from the group consisting of: halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-7b).

[0535] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b), wherein R6 is alkenyl, alkyne, phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; and

[0536] R9 and R10 are as defined with respect to Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7b).

[0537] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b), wherein R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7b).

[0538] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b), wherein

[0539] a. R3 is hydrogen; and

[0540] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A).

[0541] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7b).

[0542] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b), wherein

[0543] a. R3 is hydrogen; and

[0544] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A); and

[0545] c. R7 is a C1-C3 alkyl group.

[0546] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7b).

[0547] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b), wherein

[0548] a. R3 is hydrogen; and

[0549] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A); and

[0550] c. R7 is methyl.

[0551] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7b).

[0552] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b), wherein

[0553] a. R4 is hydrogen; and

[0554] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A).

[0555] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7b).

[0556] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b), wherein

[0557] a. R4 is hydrogen; and

[0558] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A); and

[0559] c. R7 is a C1-C3 alkyl group.

[0560] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7b).

[0561] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b), wherein

[0562] a. R4 is hydrogen; and

[0563] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A); and

[0564] c. R7 is methyl.

[0565] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7b).

[0566] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b), wherein

[0567] a. R3 and R4 are hydrogen; and

[0568] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A).

[0569] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7b).

[0570] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b), wherein

[0571] a. R3 and R4 are hydrogen; and

[0572] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A); and

[0573] c. R7 is a C1-C3 alkyl group.

[0574] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7b).

[0575] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7b), wherein

[0576] a. R3 and R4 are hydrogen; and

[0577] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A); and

[0578] c. R7 is methyl.

[0579] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7b).

[0580] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b1) and (2) compounds of any one of formulas (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b).

[0581] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b1) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b).

[0582] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b2) and (2) compounds of any of formulas (A-7b1), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0583] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b2) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0584] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b3) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0585] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b3) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0586] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b4) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0587] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b4) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0588] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b5) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0589] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b5) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0590] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b6) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0591] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b6) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0592] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b7) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0593] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b7) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0594] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b8) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0595] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b8) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0596] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b9) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0597] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b9) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0598] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b10) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0599] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b10) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0600] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b11) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0601] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b11) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0602] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b12) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0603] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b12) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b13), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0604] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b13) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0605] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b13) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b14), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0606] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b14) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0607] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b14) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b15), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0608] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b15) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0609] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b15) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b16), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0610] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b16) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b17), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0611] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b16) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b17), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0612] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b17) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), and (A-7b18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0613] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b17) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7a16), and (A-7b18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0614] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7b18) and (2) compounds of any of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), and (A-7b17). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0615] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7b18) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7b1), (A-7b2), (A-7b3), (A-7b4), (A-7b5), (A-7b6), (A-7b7), (A-7b8), (A-7b9), (A-7b10), (A-7b11), (A-7b12), (A-7b13), (A-7b14), (A-7b15), (A-7b16), and (A-7b17). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7b). Every possible combination is expressly contemplated as if expressly listed herein.

[0616] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-7c):

[0617]

[0618] wherein R3, R4 and R6 are as defined in formula (A) and R5 is hydrogen or C1-C3 alkyl. In other embodiments, such compounds are specifically excluded from formula (A).

[0619] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein R3 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c).

[0620] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein R4 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c).

[0621] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c) wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c).

[0622] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c) wherein R5 is C1-C3 alkyl. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c).

[0623] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c) wherein R5 is methyl. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c).

[0624] Structural Formula (A-7c6). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-7c), wherein R6 is hydrogen; halogen; -CN; optionally substituted alkyl; or optionally substituted alkoxy. Optional substituents for the alkyl and alkoxy groups are (1) C1-C6 hydrocarbon chains containing nitrogen or oxygen atoms and optionally substituted with C1-C3 perfluoroalkyl groups, and (2) cycloalkyl groups that may contain 1 or 2 heteroatoms selected from N, O, and S and are optionally substituted with C1-C3 perfluoroalkyl groups. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-7c).

[0625] Structural Formula (A-7c7). Some embodiments explicitly include, and some embodiments only include, compounds of Structural Formula (A-7c), wherein R6 is a side chain selected from the group consisting of: alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy, each optionally substituted with 1-3 substituents selected from the group consisting of: halogen, -CN, alkyl, perfluoroalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, and perfluoroalkoxy. In other embodiments, such compounds are explicitly excluded from Structural Formula (A) and / or (A-7c).

[0626] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein R6 is alkenyl, alkyne, phenyl, or 5- or 6-membered heteroaryl, each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of: Where n is 0, 1 or 2; and

[0627] R9 and R10 are as defined with respect to Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7c).

[0628] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7c).

[0629] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein

[0630] a. R3 is hydrogen; and

[0631] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A).

[0632] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7c).

[0633] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein

[0634] a. R3 is hydrogen; and

[0635] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A); and

[0636] R5 is a C1-C3 alkyl group.

[0637] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7c).

[0638] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein

[0639] a. R3 is hydrogen; and

[0640] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A); and

[0641] c. R5 is methyl.

[0642] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7c).

[0643] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein

[0644] a. R4 is hydrogen; and

[0645] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A).

[0646] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7c).

[0647] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein

[0648] a. R4 is hydrogen; and

[0649] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A); and

[0650] c. R5 is a C1-C3 alkyl group.

[0651] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7c).

[0652] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein

[0653] a. R4 is hydrogen; and

[0654] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A); and

[0655] c. R5 is methyl.

[0656] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7c).

[0657] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein

[0658] a. R3 and R4 are hydrogen; and

[0659] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A).

[0660] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7c).

[0661] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein

[0662] a. R3 and R4 are hydrogen; and

[0663] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A); and

[0664] c. R5 is a C1-C3 alkyl group.

[0665] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7c).

[0666] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-7c), wherein

[0667] a. R3 and R4 are hydrogen; and

[0668] b.R6 is wherein n is 0, 1 or 2; or and R9 and R10 are as defined with respect to structural formula (A); and

[0669] c. R5 is methyl.

[0670] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-7c).

[0671] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c1) and (2) compounds of any one of formulas (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c).

[0672] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c1) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c).

[0673] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c2) and (2) compounds of any of formulas (A-7c1), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0674] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c2) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0675] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c3) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0676] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c3) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0677] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c4) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0678] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c4) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0679] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c5) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0680] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c5) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0681] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c6) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0682] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c6) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0683] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c7) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0684] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c7) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0685] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c8) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0686] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c8) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0687] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c9) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0688] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c9) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0689] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c10) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0690] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c10) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0691] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c11) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0692] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c11) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0693] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c12) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0694] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c12) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c13), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0695] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c13) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0696] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c13) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c14), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0697] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c14) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0698] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c14) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c15), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0699] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c15) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0700] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c15) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c16), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0701] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c16) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c17), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0702] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c16) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c17), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0703] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c17) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), and (A-7c18). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0704] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c17) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7a16), and (A-7c18). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0705] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-7c18) and (2) compounds of any of formulas (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), and (A-7c17). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0706] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-7c18) and (2) compounds of up to 17 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17) of formula (A-7c1), (A-7c2), (A-7c3), (A-7c4), (A-7c5), (A-7c6), (A-7c7), (A-7c8), (A-7c9), (A-7c10), (A-7c11), (A-7c12), (A-7c13), (A-7c14), (A-7c15), (A-7c16), and (A-7c17). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-7c). Every possible combination is expressly contemplated as if expressly listed herein.

[0707] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-8a):

[0708]

[0709] in:

[0710] R3, R4 and R6 are as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[0711] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8a) wherein R3 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-8a).

[0712] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8a), wherein R4 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-8a).

[0713] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8a) wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-8a).

[0714] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8a), wherein

[0715] a. R3 and R4 are hydrogen and

[0716] b. R6 is hydrogen, alkyl,

[0717] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8a).

[0718] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8a), wherein

[0719] a. R3 and R4 are hydrogen and

[0720] b. R6 is an alkyl group.

[0721] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8a).

[0722] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8a), wherein

[0723] a. R3 and R4 are hydrogen and

[0724] b.R6 is

[0725] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8a).

[0726] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8a), wherein

[0727] a. R3 and R4 are hydrogen,

[0728] b.R6 is and

[0729] c. R10 is an alkyl group.

[0730] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8a).

[0731] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8a), wherein

[0732] a. R3 and R4 are hydrogen and

[0733] b.R6 is

[0734] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8a).

[0735] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8a), wherein

[0736] a. R3 and R4 are hydrogen and

[0737] b.R6 is And n is 2.

[0738] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8a).

[0739] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8a), wherein

[0740] a. R3 and R4 are hydrogen and

[0741] b.R6 is and

[0742] c. R9 and R10 together with the nitrogen atom to which they are attached form a heterocyclic ring containing 1, 2, 3 or 4 heteroatoms selected from N, O and S, which is optionally substituted by 1, 2 or 3 substituents independently selected from R11, wherein R11 is as defined in structural formula (A).

[0743] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8a).

[0744] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8a), wherein

[0745] a. R3 and R4 are hydrogen and

[0746] b.R6 is

[0747] c. R9 is alkyl or alkoxyalkyl, and

[0748] d. R10 is hydrogen.

[0749] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8a).

[0750] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-8a1) and (2) compounds of any of formulas (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-8a).

[0751] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-8a1) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-8a).

[0752] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a2) and (2) compounds of any of formulas (A-8a1), (A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0753] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a2) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8a1), (A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0754] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a3) and (2) compounds of any of formulas (A-8a1), (A-8a2), ​​(A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0755] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a3) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8a1), (A-8a2), ​​(A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly listed herein.

[0756] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a4) and (2) compounds of any of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly listed herein.

[0757] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a4) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0758] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a5) and (2) compounds of any of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a6), (A-8a7), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly listed herein.

[0759] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a5) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a6), (A-8a7), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0760] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a6) and (2) compounds of any of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a7), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0761] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a6) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a7), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly listed herein.

[0762] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a7) and (2) compounds of any of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0763] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a7) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a8), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly listed herein.

[0764] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a8) and (2) compounds of any of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0765] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a8) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a9), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly listed herein.

[0766] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a9) and (2) compounds of any of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0767] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a9) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a10), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly listed herein.

[0768] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a10) and (2) compounds of any of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a9), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly listed herein.

[0769] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a10) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a9), and (A-8a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0770] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a11) and (2) compounds of any of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a9), and (A-8a10). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated as if expressly listed herein.

[0771] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8a11) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8a1), (A-8a2), ​​(A-8a3), (A-8a4), (A-8a5), (A-8a6), (A-8a7), (A-8a8), (A-8a9), and (A-8a10). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0772] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-8b):

[0773]

[0774] in:

[0775] R3, R4 and R6 are as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[0776] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8b) wherein R3 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-8b).

[0777] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8b) wherein R4 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-8b).

[0778] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8b) wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-8b).

[0779] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8b), wherein

[0780] a. R3 and R4 are hydrogen and

[0781] b. R6 is hydrogen, alkyl,

[0782] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8b).

[0783] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8b), wherein

[0784] a. R3 and R4 are hydrogen and

[0785] b. R6 is an alkyl group.

[0786] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8b).

[0787] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8b), wherein

[0788] a. R3 and R4 are hydrogen and

[0789] b.R6 is

[0790] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8b).

[0791] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8b), wherein

[0792] a. R3 and R4 are hydrogen,

[0793] b.R6 is and

[0794] c. R10 is an alkyl group.

[0795] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8b).

[0796] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8b), wherein

[0797] a. R3 and R4 are hydrogen and

[0798] b.R6 is

[0799] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8b).

[0800] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8b), wherein

[0801] a. R3 and R4 are hydrogen and

[0802] b.R6 is And n is 2.

[0803] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8b).

[0804] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8b), wherein

[0805] a. R3 and R4 are hydrogen and

[0806] b.R6 is and

[0807] c. R9 and R10 together with the nitrogen atom to which they are attached form a heterocyclic ring containing 1, 2, 3 or 4 heteroatoms selected from N, O and S, which is optionally substituted by 1, 2 or 3 substituents independently selected from R11, wherein R11 is as defined in structural formula (A).

[0808] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8b).

[0809] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-8b), wherein

[0810] a. R3 and R4 are hydrogen and

[0811] b.R6 is

[0812] c. R9 is alkyl or alkoxyalkyl, and

[0813] d. R10 is hydrogen.

[0814] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-8b).

[0815] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-8b1) and (2) compounds of any of formulas (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-8b).

[0816] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-8b1) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-8b).

[0817] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b2) and (2) compounds of any of formulas (A-8b1), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0818] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b2) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8b1), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0819] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b3) and (2) compounds of any of formulas (A-8b1), (A-8b2), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0820] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b3) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8b1), (A-8b2), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0821] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-8b4) and (2) compounds of any of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated as if expressly listed herein.

[0822] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b4) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0823] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b5) and (2) compounds of any of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b6), (A-8b7), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0824] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b5) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b6), (A-8b7), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0825] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b6) and (2) compounds of any of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b7), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated as if expressly set forth herein.

[0826] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b6) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b7), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0827] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b7) and (2) compounds of any of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated as if expressly set forth herein.

[0828] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b7) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b8), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated as if expressly listed herein.

[0829] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b8) and (2) compounds of any of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0830] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b8) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b9), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated as if expressly listed herein.

[0831] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b9) and (2) compounds of any of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0832] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b9) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b10), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0833] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b10) and (2) compounds of any of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b9), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated as if expressly set forth herein.

[0834] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b10) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b9), and (A-8b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0835] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b11) and (2) compounds of any of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b9), and (A-8b10). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated as if expressly set forth herein.

[0836] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-8b11) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-8b1), (A-8b2), (A-8b3), (A-8b4), (A-8b5), (A-8b6), (A-8b7), (A-8b8), (A-8b9), and (A-8b10). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-8b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0837] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-9a):

[0838]

[0839] in:

[0840] R3, R4 and R6 are as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[0841] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9a), wherein R3 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-9a).

[0842] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9a), wherein R4 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-9a).

[0843] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9a), wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-9a).

[0844] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9a), wherein

[0845] a. R3 and R4 are hydrogen and

[0846] b. R6 is hydrogen, alkyl,

[0847] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9a).

[0848] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9a), wherein

[0849] a. R3 and R4 are hydrogen and

[0850] b. R6 is an alkyl group.

[0851] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9a).

[0852] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9a), wherein

[0853] a. R3 and R4 are hydrogen and

[0854] b.R6 is

[0855] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9a).

[0856] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9a), wherein

[0857] a. R3 and R4 are hydrogen,

[0858] b.R6 is and

[0859] c. R10 is an alkyl group.

[0860] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9a).

[0861] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9a), wherein

[0862] a. R3 and R4 are hydrogen and

[0863] b.R6 is

[0864] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9a).

[0865] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9a), wherein

[0866] a. R3 and R4 are hydrogen and

[0867] b.R6 is And n is 2.

[0868] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9a).

[0869] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9a), wherein

[0870] a. R3 and R4 are hydrogen and

[0871] b.R6 is and

[0872] c. R9 and R10 together with the nitrogen atom to which they are attached form a heterocyclic ring containing 1, 2, 3 or 4 heteroatoms selected from N, O and S, which is optionally substituted by 1, 2 or 3 substituents independently selected from R11, wherein R11 is as defined in structural formula (A).

[0873] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9a).

[0874] Some embodiments include only those compounds of formula (A-9a), wherein

[0875] a. R3 and R4 are hydrogen and

[0876] b.R6 is

[0877] c. R9 is alkyl or alkoxyalkyl, and

[0878] d. R10 is hydrogen.

[0879] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9a).

[0880] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-9a1) and (2) compounds of any of formulas (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-9a).

[0881] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-9a1) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-9a).

[0882] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a2) and (2) compounds of any of formulas (A-9a1), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0883] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a2) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9a1), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly listed herein.

[0884] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a3) and (2) compounds of any of formulas (A-9a1), (A-9a2), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0885] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a3) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9a1), (A-9a2), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly listed herein.

[0886] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a4) and (2) compounds of any of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0887] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a4) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly listed herein.

[0888] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a5) and (2) compounds of any of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a6), (A-9a7), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0889] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a5) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a6), (A-9a7), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated, as if expressly listed herein.

[0890] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a6) and (2) compounds of any of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a7), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0891] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a6) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a7), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly listed herein.

[0892] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a7) and (2) compounds of any of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0893] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a7) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a8), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly listed herein.

[0894] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a8) and (2) compounds of any of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0895] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a8) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a9), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly listed herein.

[0896] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a9) and (2) compounds of any of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0897] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a9) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a10), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly listed herein.

[0898] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a10) and (2) compounds of any of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a9), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0899] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a10) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a9), and (A-9a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly listed herein.

[0900] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a11) and (2) compounds of any of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a9), and (A-9a10). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly set forth herein.

[0901] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9a11) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9a1), (A-9a2), (A-9a3), (A-9a4), (A-9a5), (A-9a6), (A-9a7), (A-9a8), (A-9a9), and (A-9a10). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9a). Every possible combination is expressly contemplated as if expressly listed herein.

[0902] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-9b):

[0903]

[0904] in:

[0905] R3, R4 and R6 are as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[0906] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9b) wherein R3 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-9b).

[0907] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9b) wherein R4 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-9b).

[0908] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9b) wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-9b).

[0909] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9b), wherein

[0910] a. R3 and R4 are hydrogen and

[0911] b. R6 is hydrogen, alkyl,

[0912] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9b).

[0913] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9b), wherein

[0914] a. R3 and R4 are hydrogen and

[0915] b. R6 is an alkyl group.

[0916] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9b).

[0917] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9b), wherein

[0918] a. R3 and R4 are hydrogen and

[0919] b.R6 is

[0920] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9b).

[0921] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9b), wherein

[0922] a. R3 and R4 are hydrogen,

[0923] b.R6 is and

[0924] c. R10 is an alkyl group.

[0925] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9b).

[0926] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9b), wherein

[0927] a. R3 and R4 are hydrogen and

[0928] b.R6 is

[0929] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9b).

[0930] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9b), wherein

[0931] a. R3 and R4 are hydrogen and

[0932] b.R6 is And n is 2.

[0933] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9b).

[0934] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9b), wherein

[0935] a. R3 and R4 are hydrogen and

[0936] b.R6 is and

[0937] c. R9 and R10 together with the nitrogen atom to which they are attached form a heterocyclic ring containing 1, 2, 3 or 4 heteroatoms selected from N, O and S, which is optionally substituted by 1, 2 or 3 substituents independently selected from R11, wherein R11 is as defined in structural formula (A).

[0938] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9b).

[0939] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-9b), wherein

[0940] a. R3 and R4 are hydrogen and R6 is

[0941] b. R9 is alkyl or alkoxyalkyl, and

[0942] c. R10 is hydrogen.

[0943] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-9b).

[0944] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-9b1) and (2) compounds of any of formulas (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-9b).

[0945] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-9b1) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-9b).

[0946] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b2) and (2) compounds of any of formulas (A-9b1), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0947] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b2) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9b1), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0948] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b3) and (2) compounds of any of formulas (A-9b1), (A-9b2), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly set forth herein.

[0949] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b3) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9b1), (A-9b2), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly listed herein.

[0950] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b4) and (2) compounds of any of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly set forth herein.

[0951] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b4) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0952] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b5) and (2) compounds of any of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b6), (A-9b7), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly set forth herein.

[0953] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b5) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b6), (A-9b7), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly listed herein.

[0954] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b6) and (2) compounds of any of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b7), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly set forth herein.

[0955] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b6) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b7), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly listed herein.

[0956] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b7) and (2) compounds of any of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly set forth herein.

[0957] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b7) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b8), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly listed herein.

[0958] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b8) and (2) compounds of any of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly set forth herein.

[0959] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b8) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b9), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly listed herein.

[0960] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b9) and (2) compounds of any of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly set forth herein.

[0961] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b9) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b10), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly listed herein.

[0962] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b10) and (2) compounds of any of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b9), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[0963] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b10) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b9), and (A-9b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly listed herein.

[0964] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b11) and (2) compounds of any of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b9), and (A-9b10). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated as if expressly set forth herein.

[0965] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-9b11) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-9b1), (A-9b2), (A-9b3), (A-9b4), (A-9b5), (A-9b6), (A-9b7), (A-9b8), (A-9b9), and (A-9b10). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-9b). Every possible combination is expressly contemplated, as if expressly listed herein.

[0966] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-10a):

[0967]

[0968] in:

[0969] R3, R4 and R6 are as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[0970] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10a) wherein R3 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-10a).

[0971] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10a) wherein R4 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-10a).

[0972] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10a) wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-10a).

[0973] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10a), wherein

[0974] a. R3 and R4 are hydrogen and

[0975] b. R6 is hydrogen, alkyl,

[0976] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10a).

[0977] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10a), wherein

[0978] a. R3 and R4 are hydrogen and

[0979] b. R6 is an alkyl group.

[0980] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10a).

[0981] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10a), wherein

[0982] a. R3 and R4 are hydrogen and

[0983] b.R6 is

[0984] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10a).

[0985] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10a), wherein

[0986] a. R3 and R4 are hydrogen,

[0987] b.R6 is and

[0988] c. R10 is an alkyl group.

[0989] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10a).

[0990] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10a), wherein

[0991] a. R3 and R4 are hydrogen and

[0992] b.R6 is

[0993] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10a).

[0994] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10a), wherein

[0995] a. R3 and R4 are hydrogen and

[0996] b.R6 is And n is 2.

[0997] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10a).

[0998] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10a), wherein

[0999] a. R3 and R4 are hydrogen and

[1000] b.R6 is and

[1001] c. R9 and R10 together with the nitrogen atom to which they are attached form a heterocyclic ring containing 1, 2, 3 or 4 heteroatoms selected from N, O and S, which is optionally substituted by 1, 2 or 3 substituents independently selected from R11, wherein R11 is as defined in structural formula (A).

[1002] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10a).

[1003] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10a), wherein

[1004] a. R3 and R4 are hydrogen and

[1005] b.R6 is

[1006] c. R9 is alkyl or alkoxyalkyl, and

[1007] d. R10 is hydrogen.

[1008] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10a).

[1009] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-10a1) and (2) compounds of any of formulas (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-10a).

[1010] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-10a1) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-10a).

[1011] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a2) and (2) compounds of any of formulas (A-10a1), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1012] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a2) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10a1), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1013] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a3) and (2) compounds of any of formulas (A-10a1), (A-10a2), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1014] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a3) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10a1), (A-10a2), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1015] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a4) and (2) compounds of any of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1016] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a4) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1017] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a5) and (2) compounds of any of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a6), (A-10a7), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1018] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a5) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a6), (A-10a7), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1019] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a6) and (2) compounds of any of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a7), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[1020] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a6) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a7), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1021] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a7) and (2) compounds of any of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[1022] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a7) and (2) compounds of up to ten (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a8), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated as if expressly listed herein.

[1023] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a8) and (2) compounds of any of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[1024] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a8) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a9), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1025] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a9) and (2) compounds of any of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[1026] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a9) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a10), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1027] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a10) and (2) compounds of any of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a9), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly set forth herein.

[1028] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a10) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a9), and (A-10a11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1029] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a11) and (2) compounds of any of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a9), and (A-10a10). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated, as if expressly listed herein.

[1030] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10a11) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10a1), (A-10a2), (A-10a3), (A-10a4), (A-10a5), (A-10a6), (A-10a7), (A-10a8), (A-10a9), and (A-10a10). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10a). Every possible combination is expressly contemplated as if expressly listed herein.

[1031] Some embodiments explicitly include, and some embodiments include only, compounds having structural formula (A-10b):

[1032]

[1033] in:

[1034] R3, R4 and R6 are as defined in Structural Formula (A). In other embodiments, such compounds are specifically excluded from Structural Formula (A).

[1035] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10b) wherein R3 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-10b).

[1036] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10b) wherein R4 is hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-10b).

[1037] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10b) wherein R3 and R4 are hydrogen. In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-10b).

[1038] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10b), wherein

[1039] a. R3 and R4 are hydrogen and

[1040] b. R6 is hydrogen, alkyl,

[1041] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10b).

[1042] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10b), wherein

[1043] a. R3 and R4 are hydrogen and

[1044] b. R6 is an alkyl group.

[1045] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10b).

[1046] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10b), wherein

[1047] a. R3 and R4 are hydrogen and

[1048] b.R6 is

[1049] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10b).

[1050] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10b), wherein

[1051] a. R3 and R4 are hydrogen,

[1052] b.R6 is and

[1053] c. R10 is an alkyl group.

[1054] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10b).

[1055] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10b), wherein

[1056] a. R3 and R4 are hydrogen and

[1057] b.R6 is

[1058] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10b).

[1059] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10b), wherein

[1060] a. R3 and R4 are hydrogen and

[1061] b.R6 is And n is 2.

[1062] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10b).

[1063] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10b), wherein

[1064] a. R3 and R4 are hydrogen and

[1065] b.R6 is and

[1066] c. R9 and R10 together with the nitrogen atom to which they are attached form a heterocyclic ring containing 1, 2, 3 or 4 heteroatoms selected from N, O and S, which is optionally substituted by 1, 2 or 3 substituents independently selected from R11, wherein R11 is as defined in structural formula (A).

[1067] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10b).

[1068] Some embodiments specifically include, and some embodiments only include, compounds of formula (A-10b), wherein

[1069] a. R3 and R4 are hydrogen and R6 is

[1070] b. R9 is alkyl or alkoxyalkyl, and

[1071] c. R10 is hydrogen.

[1072] In other embodiments, such compounds are specifically excluded from Structural Formula (A) and / or (A-10b).

[1073] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-10b1) and (2) compounds of any of formulas (A-10b2), (A-10b3), (A-10b4), (A-10b5), (A-10b6), (A-10b7), (A-10b8), (A-10b9), (A-10b10), and (A-10b11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-10b).

[1074] Some embodiments specifically include, and some embodiments only include, (1) compounds of formula (A-10b1) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10b2), (A-10b3), (A-10b4), (A-10b5), (A-10b6), (A-10b7), (A-10b8), (A-10b9), (A-10b10), and (A-10b11). In other embodiments, such compounds are specifically excluded from formula (A) and / or (A-10b).

[1075] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10b2) and (2) compounds of any of formulas (A-10b1), (A-10b3), (A-10b4), (A-10b5), (A-10b6), (A-10b7), (A-10b8), (A-10b9), (A-10b10), and (A-10b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[1076] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10b2) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10b1), (A-10b3), (A-10b4), (A-10b5), (A-10b6), (A-10b7), (A-10b8), (A-10b9), (A-10b10), and (A-10b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10b). Every possible combination is expressly contemplated, as if expressly listed herein.

[1077] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10b3) and (2) compounds of any of formulas (A-10b1), (A-10b2), (A-10b4), (A-10b5), (A-10b6), (A-10b7), (A-10b8), (A-10b9), (A-10b10), and (A-10b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[1078] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10b3) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10b1), (A-10b2), (A-10b4), (A-10b5), (A-10b6), (A-10b7), (A-10b8), (A-10b9), (A-10b10), and (A-10b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10b). Every possible combination is expressly contemplated, as if expressly listed herein.

[1079] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10b4) and (2) compounds of any of formulas (A-10b1), (A-10b2), (A-10b3), (A-10b5), (A-10b6), (A-10b7), (A-10b8), (A-10b9), (A-10b10), and (A-10b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[1080] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10b4) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10b1), (A-10b2), (A-10b3), (A-10b5), (A-10b6), (A-10b7), (A-10b8), (A-10b9), (A-10b10), and (A-10b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10b). Every possible combination is expressly contemplated, as if expressly listed herein.

[1081] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10b5) and (2) compounds of any of formulas (A-10b1), (A-10b2), (A-10b3), (A-10b4), (A-10b6), (A-10b7), (A-10b8), (A-10b9), (A-10b10), and (A-10b11). In other embodiments, such compounds are explicitly excluded from formula (A) and / or (A-10b). Every possible combination is expressly contemplated, as if expressly set forth herein.

[1082] Some embodiments explicitly include, and some embodiments only include, (1) compounds of formula (A-10b5) and (2) compounds of up to 10 (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) of formulas (A-10b1), (A-10b2), (A-10b3), (A-10b4), (A-10b6), (A-10b7), (A-10b8), (A-10b9), (A-10b10), and (A-10b11). In other embodiments, such compounds are explicitly excluded ...

Claims

1. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is represented by structural formula (A-1): in: R3 is hydrogen; halogen; C1-C6 alkyl or C1-C6 alkoxy, each optionally substituted by: a C1-C6 hydrocarbon chain containing N or O atoms; R4 is hydrogen; or C1-C6 alkoxy, optionally substituted by a group selected from the group consisting of: a C1-C6 hydrocarbon chain containing N or O atoms; R5 is R21; R6 is R21; Where n is 1 or 2; or R5 and R6 together with the carbon atom to which they are attached form a 5-membered cycloalkyl group; R9 is: C1-C6 alkyl; C1-C6 alkoxy-C1-C6 alkyl; or wherein n is 0, 1, 2 or 3; R10 is hydrogen; or R9 and R10 together with the nitrogen atom to which they are attached form a 3- to 7-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, O and S, which is optionally substituted with 1, 2 or 3 substituents independently selected from R11; R11 is hydrogen or C1–C6 alkyl; R12 is C1-C6 alkoxy; or a 5- or 6-membered heterocyclic ring having 1, 2 or 3 heteroatoms selected from N, O and S and optionally substituted with 1, 2 or 3 substituents independently selected from R11; R21 is a C1-C6 alkyl group, or a C1-C6 alkoxy-C1-C6 alkyl group, Provided that, if R3 and R4 are both hydrogen and R5 is methyl, then R6 cannot be ethyl.

2. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R6 is Where n is 1 or 2; R9 is C1-C6 alkyl; or C1-C6 alkoxy-C1-C6 alkyl; R10 is hydrogen.

3. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R6 is Where n is 1 or 2; R9 is wherein n is 0, 1, 2 or 3; R10 is hydrogen; or R9 and R10 together with the nitrogen atom to which they are attached form a 3- to 7-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, O and S, which is optionally substituted with 1, 2 or 3 substituents independently selected from R11.

4. The compound according to claim 2 or 3, or a pharmaceutically acceptable salt thereof, wherein: R3 is hydrogen; or halogen; R5 is a C1-C6 alkyl group.

5. The compound according to claim 2 or 3 or a pharmaceutically acceptable salt thereof, wherein: R3 is C1–C6 alkyl; or C1–C6 alkoxy; R4 is hydrogen.

6. The compound according to claim 2 or 3 or a pharmaceutically acceptable salt thereof, wherein: R3 is a C1–C6 alkoxy group substituted by a group selected from the group consisting of: a C1–C6 hydrocarbon chain containing a N or O atom; R4 is hydrogen; R5 is a C1-C6 alkyl group.

7. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R6 is C1-C6 alkyl, or C1-C6 alkoxy-C1-C6 alkyl.

8. The compound according to claim 7 or a pharmaceutically acceptable salt thereof, wherein: R3 is C1–C6 alkyl; or C1–C6 alkoxy; R4 is hydrogen.

9. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from:

10. A compound or a pharmaceutically acceptable salt thereof, wherein: The compound is:

11. A compound or a pharmaceutically acceptable salt thereof, wherein: The compound is:

12. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is as follows:

13. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; wherein the compound is represented by structural formula (A-1): in: R3 is hydrogen; fluorine; C1-C6 alkyl or C1-C6 alkoxy, each optionally substituted by: a C1-C6 hydrocarbon chain containing N or O atoms; R4 is hydrogen; or C1-C6 alkoxy, optionally substituted by a group selected from the group consisting of: a C1-C6 hydrocarbon chain containing N or O atoms; R5 is a C1–C6 alkyl group; R6 is C1-C6 alkoxy-C1-C6 alkyl; Where n is 1 or 2; or R5 and R6 together with the carbon atom to which they are attached form a 5-membered cycloalkyl group; R9 is: C1-C6 alkyl; R10 is hydrogen; or R9 and R10 together with the nitrogen atom to which they are attached form a 3- to 7-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, O and S, which is optionally substituted with 1, 2 or 3 substituents independently selected from R11; R11 is hydrogen or C1-C6 alkyl.

14. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; wherein the compound is selected from:

15. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; wherein the compound is:

16. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; wherein the compound is:

17. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; wherein the compound is as follows:

18. Use of a compound or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating myeloma, wherein the compound is represented by structural formula (A-1): in: R3 is hydrogen; fluorine; C1-C6 alkyl or C1-C6 alkoxy, each optionally substituted by: a C1-C6 hydrocarbon chain containing N or O atoms; R4 is hydrogen; or C1-C6 alkoxy, optionally substituted by a group selected from the group consisting of: a C1-C6 hydrocarbon chain containing N or O atoms; R5 is a C1–C6 alkyl group; R6 is C1-C6 alkoxy-C1-C6 alkyl; Where n is 1 or 2; or R5 and R6 together with the carbon atom to which they are attached form a 5-membered cycloalkyl group; R9 is: C1-C6 alkyl; R10 is hydrogen; or R9 and R10 together with the nitrogen atom to which they are attached form a 3- to 7-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, O and S, which is optionally substituted with 1, 2 or 3 substituents independently selected from R11; R11 is hydrogen or C1-C6 alkyl.

19. Use of a compound or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating myeloma; wherein the compound is selected from:

20. Use of a compound or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating myeloma; wherein the compound is:

21. Use of a compound or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating myeloma; wherein the compound is:

22. Use of a compound or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating myeloma; wherein the compound is as follows:

23. The use according to any one of claims 18 to 22, wherein the myeloma is multiple myeloma.

Images