Antibodies that specifically bind to human IL-1R7

Abstract

The present invention relates to a monoclonal antibody that specifically binds to human IL-1 R7, or a fragment or derivative thereof, or a polypeptide comprising at least a portion of the antibody sufficient to confer binding specificity of IL-1 R7 to the polypeptide. The present invention also relates to the use of the antibody in treating IL-18-mediated diseases and a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention.

Description

Technical Field

[0001] The present invention relates to a monoclonal antibody or an antigen-binding fragment thereof that specifically binds to human IL-1R7, and also relates to the use of the antibody and a pharmaceutical composition containing the antibody. Background Art

[0002] IL-1R7 is the co-receptor of IL-18 signal transduction, which is also referred to as IL-18 receptor β chain.IL-18 is classified as one of the members of the IL-1 cytokine superfamily, and it is used as the important regulator of innate and acquired immune response (Garcia et al., 2003; Dinarello et al., 2013). It plays the role of effector and regulator in various early inflammatory responses and is known in autoimmune diseases, in various cancers and in the case of many infectious diseases, in the position expression of chronic inflammation (Lebel-Binay et al., 2000; Diakowska et al., 2006; Kinjo et al., 2002; Fabbi et al., 2015).

[0003] The IL-18 family of cytokines is synthesized as a precursor molecule and is cleaved by the caspase-1 enzyme before or during release from the cell. After release from the cell, IL-18 signal transduction occurs through receptor binding. One of its main receptors is IL-1R5, also known as the IL-18 receptor α chain. More specifically, it is known that the receptor complex composed of IL-1R5 and IL-1R7 transduces IL-18 signaling (Debets et al., 2000).

[0004] Following ligand binding, the pro-inflammatory IL-18 signaling cascade continues, leading to the activation and transcription of numerous target genes that influence the activation of multiple cell types such as macrophages, dendritic cells, mast cells, B and T cells, fibroblasts, and many others.

[0005] The IL-1 and IL-18 families of cytokines share many similarities, such as their receptor structures and the signal transduction pathways they utilize. For example, IL-1R5 plays the same role in the IL-18 pathway as IL-1R3 does in the IL-1 family signaling pathway.

[0006] Most IL-1 family members achieve signal transduction through heterodimer plasma membrane receptors, and most of them utilize a common signal transduction chain (IL-1R3) (Riva et al., 2012). The blocking of IL-1R3 leads to problematic results, because IL-1R3 is a receptor for several interleukins and therefore achieves various functions (pro-inflammatory and anti-inflammatory signal cascades). Similar to IL-1R3, it is very difficult to find antibodies that effectively inhibit signal transduction pathways by blocking human IL-1R7. The fact that this type of effective antibody is not disclosed in the literature proves this point.

[0007] Many antibodies that inhibit the effects of IL-18 by directly binding to IL-18 have been described (US 2014 / 0112915; US 2014 / 0004128; US 2013 / 0101595). However, previous experience with direct inhibition of IL-18 has produced conflicting results. Therefore, other methods for inhibiting the IL-18 signaling pathway are needed, for example by blocking its receptor IL-1R5. For this purpose, several antibodies are known (WO 2007 / 096396).

[0008] However, IL-1R5 serves not only as a receptor for IL-18, but also as a receptor for the anti-inflammatory cytokine IL-37. The binding of IL-18 to IL-15 leads to pro-inflammatory effects, while the binding of IL-37 to IL-1R5 leads to anti-inflammatory effects (Mologora et al., 2016). Therefore, blockade of the IL-1R5 receptor may be counterproductive in the treatment of patients with IL-18-resistant forms, as it may interfere with other mechanisms that may be beneficial to such patients. Therefore, inhibition of IL-1R7 remains the only selective anti-inflammatory intervention.

[0009] Furthermore, although IL-1R5 is a functional component of the IL-18 receptor, its binding affinity for IL-18 is relatively low, and IL-1R7 is required for high-affinity binding of IL-18. To date, known antibodies that inhibit IL-18-mediated signaling by blocking IL-1R5 and IL-1R7 do not possess potency that would allow their use as therapeutic antibodies.

[0010] The expression of IL-1R7 was confirmed in Th1 cells, and the role of IL-1R7 in Th1-mediated pathology was elucidated (Debets et al., 2000). Debets et al. developed anti-IL-1R7 mouse antibodies (anti-IL-1R7 mAb: TC30-28E3, anti-IL-18 mAb: C18.6), which effectively inhibited the IL-18 response in vitro, confirming the important role of IL-1R7 in IL-18 activity. However, the antibodies developed by Debets and colleagues are rat anti-mouse antibodies and have only been tested in vitro. It has been proven that the development of effective antibodies with high specificity for human IL-1R7 is difficult and has not yet been achieved.

[0011] Therefore, there is a need for effective antibodies against human IL-1R7. The antibodies of the present invention address this need. Summary of the Invention

[0012] A first aspect of the present invention provides a monoclonal antibody that specifically binds to human IL-1R7, or an antigen-binding fragment or polypeptide thereof, wherein the antigen-binding fragment or polypeptide comprises at least a portion of the antibody sufficient to confer binding specificity to IL-1R7. The present invention also relates to compositions comprising the antibody and methods for treating IL-18-mediated diseases. Specific implementation plan

[0013] definition

[0014] The term "rabbit" according to the present invention means an animal that is a member of the taxonomic order Lagomorpha, which includes the family Ochotonidae (hares and rabbits) and the family Ochotonidae (pikas), preferably of the genus Oryctolagus.

[0015] The term "antibody" encompasses various forms of antibody structures, including but not limited to, whole antibodies and antibody fragments, so long as they exhibit the properties according to the present invention.

[0016] The term "rabbit monoclonal antibody" according to the present invention means a monoclonal antibody produced by immunizing a rabbit and isolating from antibody-producing cells of the rabbit, as well as further modified such antibodies, preferably humanized antibodies, chimeric antibodies, fragments thereof, or further genetically engineered or recombinantly produced antibodies, as long as the characteristic properties according to the present invention are retained. Preferably, the antibody is derived from rabbit B cells or rabbit hybridoma cells.

[0017] The term "antibody-producing cell" according to the present invention means a rabbit B cell, which produces an antibody, preferably a B cell or a rabbit hybridoma cell.

[0018] "Native antibodies" are typically heterotetrameric glycoproteins consisting of two identical light (L) chains and two identical heavy (H) chains. Each light chain is linked to a heavy chain by a covalent disulfide bond, with the number of disulfide bonds varying between heavy chains of different immunoglobulin isotypes. Each heavy and light chain also has regularly spaced intrachain disulfide bridges. Each heavy chain has a variable domain (VH) at one end, followed by multiple constant domains. Each light chain has a variable domain (VL) at one end and a constant domain at its other end. The constant domain of the light chain is aligned with the first constant domain of the heavy chain, and the light chain variable domain is aligned with the heavy chain variable domain. It is believed that specific amino acid residues form an interface between the light chain and heavy chain variable domains.

[0019] "Percent (%) amino acid sequence identity" for peptide or polypeptide sequences is defined as the percentage of amino acid residues in a candidate sequence that are identical with the amino acid residues in a specified peptide or polypeptide sequence, after aligning the sequences and introducing gaps, as necessary, to achieve the maximum percent sequence identity and not considering any conservative substitutions as part of the sequence identity. Alignment for purposes of determining percent amino acid sequence identity can be achieved in various ways that are within the skill in the art, for example, using publicly available computer software such as BLAST, BLAST-2, ALIGN, or Megalign (DNASTAR) software.

[0020] "Constant domain (constant part)" is not directly involved in the binding of an antibody to an antigen, but also represents, for example, effector functions. The heavy chain constant region gene segment corresponding to human IgG1 is called the γ1 chain. The heavy chain constant region gene segment corresponding to human IgG3 is called the γ3 chain. Human constant γ heavy chains are described in detail by Kabat, EA et al., Sequences of Proteins of Immunological Interest, 5th Edition, Public Health Service, National Institutes of Health, Bethesda, MD. (1991), and Brueggemann, M., et al., J. Exp. Med. 166 (1987) 1351-1361; Love, TW, et al., Methods Enzymol. 178 (1989) 515-527.

[0021] IgG1 or IgG3 type constant domains are glycosylated at Asn 297. "Asn 297" according to the present invention refers to the amino acid asparagine located at approximately position 297 in the Fc region; based on small sequence variations of antibodies, Asn 297 may also be located at some amino acids upstream or downstream (usually no more than +3 amino acids).

[0022] As used herein, the term "antibody effector function" or "effector function" refers to the function provided by one (or more) Fc effector domains of IgG (e.g., the Fc region of an immunoglobulin). Such functions can be achieved, for example, by binding of one (or more) Fc effector domains to Fc receptors on immune cells with phagocytic or lytic activity, or by binding of one (or more) Fc effector domains to components of the complement system. Typical effector functions are ADCC, ADCP, and CDC.

[0023] "Antibody fragment" refers to a molecule other than an intact antibody that comprises a portion of an intact antibody that binds to the antigen to which the intact antibody binds. Examples of antibody fragments include, but are not limited to, Fv, Fab, Fab', Fab'-SH, F(ab')2; diabodies; linear antibodies; single-chain antibody molecules (e.g., scFv); and multispecific antibodies formed from antibody fragments.

[0024] An "antibody that binds to the same epitope as a reference antibody" is one that blocks binding of the reference antibody to its antigen by more than 50% in a competition assay, whereas the reference antibody blocks binding of the antibody to its antigen by more than 50% in a competition assay. Exemplary competition assays are provided herein.

[0025] "Antibody-dependent cell-mediated cytotoxicity" and "ADCC" refer to a cell-mediated reaction in which nonspecific cytotoxic cells expressing FcRs (e.g., natural killer (NK) cells, neutrophils, and macrophages) recognize bound antibodies on target cells and subsequently cause lysis of the target cells. Primary cells that mediate ADCC, NK cells, express only FcγRIII, while monocytes express FcγRI, FcγRII, and FcγRIII. FcR expression on hematopoietic cells is summarized in Table 3 on page 464 of Ravetch, and Kinet, Annu. Rev. Immunol 9 (1991) 457-492. The terms "antibody-dependent cellular phagocytosis" and "ADCP" refer to the process by which antibody-coated cells are internalized in whole or in part by phagocytic immune cells (e.g., macrophages, neutrophils, and dendritic cells) that bind to the Fc region of an immunoglobulin.

[0026] "Clq" is a polypeptide that includes the binding site of the Fc region of an immunoglobulin. Clq, together with two serine proteases, Clr and Cls, forms complex Cl, the first component of the complement-dependent cytotoxicity (CDC) pathway. Human Clq is commercially available, for example, from Quidel, San Diego, California.

[0027] The "class" of an antibody refers to the type of constant domain or region possessed by its heavy chain. There are five major classes of antibodies: IgA, IgD, IgE, IgG, and IgM, and several of these classes are further divided into subclasses (isotypes), e.g., IgG1, IgG2, IgG3, IgG4, IgA1, and IgA2. The heavy chain constant domains corresponding to the different classes of immunoglobulins are called alpha, delta, epsilon, gamma, and mu, respectively.

[0028] An "effective amount" of an agent, such as a pharmaceutical agent, refers to an amount effective, at dosages and for periods of time necessary, to achieve the desired therapeutic or prophylactic result.

[0029] The term "Fc region" is used herein to define the C-terminal region of an immunoglobulin heavy chain, which includes at least a portion of the constant region. The term includes native sequence Fc regions and variant Fc regions.

[0030] Unless otherwise indicated herein, the numbering of amino acid residues in the Fc region or constant region is according to the EU numbering system, also known as the EU index, as described by Kabat, et al., Sequences of Proteins of Immunological Interest, 5th ed. Public Health Service, National Institutes of Health, Bethesda, MD (1991).

[0031] A "variant Fc region" comprises an amino acid sequence that differs from that of a "native" or "wild-type" sequence Fc region by virtue of at least one "amino acid modification" as described herein.

[0032] As used herein, the term "Fc-variant" refers to a polypeptide comprising a modification in the Fc domain. The modification may be an addition, deletion, or substitution. The substitution may include naturally occurring amino acids or non-naturally occurring amino acids. Variants may include non-natural amino acids.

[0033] The term "Fc region-containing polypeptide" refers to a polypeptide, such as an antibody or immunoadhesin (see definition below), that comprises an Fc region.

[0034] The term "Fc receptor" or "FcR" is used to describe a receptor that binds to the Fc region of an antibody. The FcR (gamma receptor) that binds to IgG antibodies includes receptors of the FcγRI, FcγRII, and FcγRIII subclasses, including allelic variants and alternatively spliced ​​forms of these receptors. FcγRII receptors include FcγRIIA ("activating receptor") and FcγRIIB ("inhibiting receptor"), which have similar amino acid sequences that differ primarily in their cytoplasmic domains. The activating receptor FcγRIIA contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The inhibitory receptor FcγRIIB contains an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic domain (see Daeron, M., Annu. Rev. Immunol. 15 (1997) 203-234 for review). FcRs are reviewed in Ravetch, and Kinet, Annu. Rev. Immunol 9 (1991) 457-492; Capel, et al., Immunomethods 4 (1994) 25-34; and de Haas, et al., J. Lab. Clin. Med. 126 (1995) 330-41. Other FcRs, including those identified in the future, are encompassed herein by the term "FcR." The term also includes the neonatal receptor FcRn, which is responsible for the transfer of maternal IgG to the fetus (Guyer, et al., J. Immunol. 117 (1976) 587 and Kim, et al., J. Immunol. 24 (1994) 249).

[0035] As used herein, "IgG Fc ligand" means a molecule, preferably a polypeptide, from any organism that binds to the Fc region of an IgG antibody to form an Fc / Fc ligand complex. Fc ligands include, but are not limited to, FcγRs, FcRn, C1q, C3, mannan-binding lectins, mannose receptors, Staphylococcal protein A, Streptococcal protein G, and viral FcγRs. Fc ligands also include Fc receptor homologs (FcRHs), which are a family of Fc receptors homologous to FcγRs (Davis, et al., Immunological Reviews 190 (2002) 123-136, which is incorporated by reference in its entirety). Fc ligands may include undiscovered molecules that bind to Fc. Specific IgG Fc ligands are FcRn and Fcγ receptors. As used herein, "Fc ligand" means a molecule, preferably a polypeptide, from any organism that binds to the Fc region of an antibody to form an Fc / Fc ligand complex.

[0036] As used herein, "Fcγ receptor," "FcyR," or "FcyR" means any member of the family of proteins that bind to the Fc region of an IgG antibody and are encoded by an FcyR gene. In humans, this family includes, but is not limited to, FcγRI (CD64), including isoforms FcγRIA, FcγRIB, and FcγRIC; FcγRII (CD32), including isoforms FcγRIIA (including allotypes H131 and R131), FcγRIIB (including FcγRIIB-1 and FcγRIIB-2), and FcγRIIc; and FcγRIII (CD 16), including isoforms FcγRIIIA (including allotypes V158 and F158) and FcγRIIIb (including allotypes FcγRIIB-NA1 and FcγRIIB-NA2) (Jefferis, et al., Immunol Lett 82 (2002) 57-65, which is incorporated by reference in its entirety), as well as any undiscovered human FcγR or FcγR isoform or allotype. FcγRs can be from any organism, including but not limited to humans, mice, rats, rabbits, and monkeys. Mouse FcyRs include, but are not limited to, FcyRI (CD64), FcyRII (CD32), FcyRIII (CD 16), and FcyRIII-2 (CD 16-2), as well as any undiscovered mouse FcyR or FcyR isoform or allotype.

[0037] As used herein, "FcRn" or "neonatal Fc receptor" refers to a protein that binds to the Fc region of an IgG antibody and is encoded at least in part by an FcRn gene. FcRn can be derived from any organism, including but not limited to humans, mice, rats, rabbits, and monkeys. As is known in the art, a functional FcRn protein comprises two polypeptides, commonly referred to as a heavy chain and a light chain. The light chain is β-2-microglobulin, and the heavy chain is encoded by the FcRn gene. Unless otherwise indicated herein, references to FcRn or FcRn protein refer to the complex of the FcRn heavy chain and β-2-microglobulin.

[0038] "Immunoconjugate" means an antibody conjugated to one or more cytotoxic agents, such as chemotherapeutic agents, drugs, growth inhibitory agents, toxins, other antibodies, or radioactive isotopes.

[0039] The terms "monoclonal antibody" or "monoclonal antibody composition" as used herein refer to a preparation of antibody molecules of single amino acid composition.

[0040] The term "humanized antibody" or "humanized version of an antibody" refers to an antibody in which both the heavy and light chains have been humanized as a result of antibody engineering. Humanized chains are typically those in which the amino acid sequence of the V region has been altered so that, when analyzed as a whole, the V region is closer in homology to human germline sequences than to the germline sequences of the original species. The assessment of humanization is based on the resulting amino acid sequence rather than the method itself.

[0041] As used herein, the term "specific binding, directed against a target, or anti-target antibody" refers to the binding of an antibody to a corresponding antigen (target) or antigen-expressing cells as measured by ELISA, wherein the ELISA preferably comprises coating the corresponding antigen onto a solid support, adding the antibody under conditions that allow the formation of an immune complex with the corresponding antigen or protein, and detecting the immune complex by using a secondary antibody that binds to the antibody according to the present invention and measuring the optical density value (OD) using peroxidase-mediated color development.

[0042] The term "antigen" according to the present invention refers to an antigen used for immunization or a protein comprising the antigen as part of its protein sequence. For example, for immunization, a fragment of the extracellular domain of a protein (e.g., the first 20 amino acids) can be used, and for detection / analysis, the extracellular domain of a protein or the full-length protein can be used.

[0043] The term "specifically binds" or "specifically recognizes" as used herein means that the antibody shows an appreciable affinity for the antigen, and preferably does not show significant cross-reactivity.

[0044] An antibody that "does not show significant cross-reactivity" is one that does not significantly bind to other proteins where it is not desired. Specific binding can be determined according to any art-known method for determining such binding, for example, by a competitive binding assay (eg, ELISA).

[0045] As used herein, the "variable region (or domain) of an antibody according to the present invention" (variable region of the light chain (VL), variable region of the heavy chain (VH)) refers to each of the pair of light and heavy chain regions that are directly involved in binding the antibody to the antigen. The variable light and heavy chain regions have the same general structure, and each region comprises four framework (FR) regions whose sequences are widely conserved and connected by three complementarity determining regions (CDRs).

[0046] When used herein, the term "antigen-binding portion of an antibody" refers to the amino acid residues of an antibody that are responsible for antigen binding. The antigen-binding portion of an antibody preferably includes amino acid residues from "complementarity determining regions" or "CDRs." CDR sequences are defined according to Kabat et al., Sequences of Proteins of Immunological Interest, Fifth Edition. Public Health Service, National Institutes of Health, Bethesda, Md. (1991). Using this numbering system, the actual linear amino acid sequence may include fewer or additional amino acids corresponding to the shortening or insertion of the FR or CDR of the variable region. For example, the heavy chain variable region may include a single amino acid insertion after residue 52 of H2 (residue 52a according to Kabat) and an insertion residue after heavy chain FR residue 82 (e.g., residues 82a, 82b, and 82c according to Kabat, etc.). The Kabat numbering of the residues of a given antibody can be determined by aligning the homology regions of the antibody sequence with the "standard" Kabat numbering sequence.

[0047] As used herein, the term "cancer" can be, for example, lung cancer, non-small cell lung (NSCL) cancer, bronchioloalveolar cell lung cancer, bone cancer, pancreatic cancer, skin cancer, head and neck cancer, skin or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer, cancer of the anal region, gastrointestinal cancer, stomach cancer, colon cancer, breast cancer, uterine cancer, fallopian tube cancer, endometrial cancer, cervical cancer, vaginal cancer, vulvar cancer, Hodgkin's disease, esophageal cancer, small intestine cancer, cancer of the endocrine system, thyroid cancer, parathyroid cancer, adrenal cancer, soft tissue cancer. Sarcoma, urethral cancer, penile cancer, prostate cancer, bladder cancer, kidney cancer or ureteral cancer, renal cell carcinoma, renal pelvic cancer, mesothelioma, hepatocellular carcinoma, biliary cancer, central nervous system (CNS) tumors, spinal axis tumors, brain stem glioma, glioblastoma multiforme, astrocytoma, schwannoma, ependymoma, medulloblastoma, meningioma, squamous cell carcinoma, pituitary adenoma, lymphoma, lymphocytic leukemia, including refractory forms of any of the above cancers, or one or more combinations of the above cancers. Such cancers are preferably breast cancer, colon cancer, lung cancer, or pancreatic cancer.

[0048] As used herein, the term "IL-18-associated disease" includes, but is not limited to, rheumatoid arthritis, osteoarthritis, juvenile idiopathic arthritis, Lyme disease, psoriatic arthritis, reactive arthritis, spondyloarthropathies, lupus (e.g., systemic lupus erythematosus, and lupus nephritis), Crohn's disease, ulcerative colitis, inflammatory bowel disease, insulin-dependent diabetes mellitus, thyroiditis, asthma, allergic diseases, psoriasis, psoriasis type 1, psoriasis type 2, scleroderma, graft-versus-host disease, organ transplant rejection, organ transplant-related acute or chronic immune diseases, sarcoidosis, atherosclerosis, disseminated intravascular coagulation, Kawasaki disease, Graves' disease, nephrotic syndrome, chronic fatigue syndrome, Wegener's granulomatosis, Henoch-Schonlein purpura, renal microvascular disease, and inflammatory bowel disease. angitis, chronic active hepatitis, uveitis, septic shock, toxic shock syndrome, septicemia, cachexia, infectious diseases, parasitic diseases, acute transverse myelitis, Huntington's disease, Parkinson's disease, Alzheimer's disease, stroke, primary biliary cirrhosis, hemolytic anemia, malignancy, heart failure, myocardial infarction, Addison's disease, sporadic polyglandular deficiency type I and type II, Schmidt's disease, adult respiratory distress syndrome, alopecia, alopecia areata, seronegative arthritis, arthropathy, Rett's disease, psoriatic arthritis, ulcerative colitis arthropathy, enteropathic synovitis, arthropathy associated with Chlamydia, Yersinia, and Salmonella, spondyloarthropathy, atheromatous disease disease), atherosclerosis, atopic allergy, autoimmune bullous diseases, pemphigus vulgaris, pemphigus foliaceus, pemphigoid, linear IgA disease, autoimmune hemolytic anemia, Coombs-positive hemolytic anemia, acquired pernicious anemia, juvenile pernicious anemia, myalgic encephalomyelitis / RoyalFree's disease, chronic mucocutaneous candidiasis, giant cell arteritis, primary sclerosing hepatitis, cryptogenic autoimmune hepatitis, acquired immunodeficiency syndrome, acquired immunodeficiency-related diseases, hepatitis C, common variable immunodeficiency, common variable hypogammaglobulinemia, dilated cardiomyopathy, female infertility, ovarian failure, premature ovarian failure, fibrosing lung disease, cryptogenic fibrosing alveolitis, postinflammatory interstitial lung disease, interstitial lung disease, interstitial lung disease associated with connective tissue disease, lung disease associated with mixed connective tissue disease, interstitial lung disease associated with systemic sclerosis, interstitial lung disease associated with rheumatoid arthritis Lung disease associated with systemic lupus erythematosus, lung disease associated with dermatomyositis / polymyositis, lung disease associated with Sjögren's disease, lung disease associated with ankylosing spondylitis, diffuse vasculitic lung disease, lung disease associated with hemosiderosis, drug-induced interstitial lung disease, radiation-induced fibrosis, bronchiolitis obliterans, chronic eosinophilic pneumonia, lymphocytic lung disease, post-infectious interstitial lung disease, gouty arthritis, autoimmune hepatitis, autoimmune hepatitis type 1, traditional autoimmune or lupus-like hepatitis, autoimmune hepatitis type 2, anti-LKM antibody hepatitis, autoimmune-mediated hypoglycemia, insulin type B Against acanthosis nigricans, hypoparathyroidism, acute immune diseases associated with organ transplantation, chronic immune diseases associated with organ transplantation, osteoarthritis, primary sclerosing cholangitis, idiopathic leukopenia, autoimmune neutropenia, kidney disease NOS, glomerulonephritis, microscopic vasculitis of the kidney, Lyme disease, discoid lupus erythematosus, primary male infertility NOS, sperm autoimmunity, all subtypes of multiple sclerosis, sympathetic ophthalmia, pulmonary hypertension secondary to connective tissue disease, Cuban-Jackson syndrome, pulmonary manifestations of polyarteritis nodosa, acute rheumatic fever, rheumatoid spondylitis, Still's disease, systemic sclerosis, Sjögren's syndrome, Takayasu's disease / Takayasu's arteritis, autoimmune thrombocytopenia, idiopathic thrombocytopenia, autoimmune thyroid disease, hyperthyroidism, goiter autoimmune hypothyroidism or Hashimoto's disease, atrophic autoimmune hypothyroidism, primary myxedema, lenticular uveitis, primary vasculitis, vitiligo, acute liver disease, chronic liver disease, allergies and asthma, mental disorders, depression, schizophrenia, Th2-type and Th1-type mediated diseases, chronic obstructive pulmonary disease (COPD), inflammation, autoimmunity and bone diseases. The term "IL-18-related disease" further includes cancer-induced forms of chronic inflammation such as tumor-induced. Detailed Description of the Invention

[0050] The present invention relates to monoclonal antibodies, or antigen-binding fragments thereof, that are capable of binding to human IL-1R7. As outlined above, the development of such antibodies has proven to be very difficult, and prior to the existence of the antibodies of the present invention, there were no antibodies that could bind to the human form of IL-1R7. Furthermore, it is not known whether antibodies exist that bind to human IL-1R7 with sufficient specificity and potency to permit their use as therapeutic agents. Due to the difficulties previously experienced in producing such antibodies, the possibility of developing and obtaining such antibodies was not anticipated.

[0051] The inventors have therefore very surprisingly found that the antibodies of the present invention exhibit the beneficial and advantageous characteristics as described below and described in further detail below.

[0052] In one aspect of the invention, the antibody or antigen-binding fragment comprises a VH region selected from the group comprising the following CDR regions: the CDR regions are selected from the group consisting of the CDR1H regions of SEQ ID NO: 297+n, the CDR2H regions of SEQ ID NO: 445+n, and the CDR3H regions of SEQ ID NO: 593+n, wherein n is a number selected from the group consisting of 0 to 147; and a VL region selected from the group comprising the following CDR regions: the CDR regions are selected from the group consisting of the CDR1L regions of SEQ ID NO: 741+m, the CDR2L regions of SEQ ID NO: 889+m, and the CDR3L regions of SEQ ID NO: 1037+m, or the CDR3L regions of SEQ ID NO: 1205 or 1206, wherein m is a number selected from the group consisting of 0 to 147, wherein the CDRs of the VH or VL chain may comprise any one or more amino acid mutations that do not reduce their activity according to the present invention.

[0053] In another aspect of the invention, the antibody or antigen-binding fragment comprises a VH region selected from the group comprising a VH region comprising three CDRs that are at least 90% identical to a group of three CDR regions selected from the group consisting of: a CDR1H region of SEQ ID NO: 297+n, a CDR2H region of SEQ ID NO: 445+n, and a CDR3H region of SEQ ID NO: 593+n, wherein n is a number selected from the group consisting of 0 to 147; and a VL region selected from the group comprising a VL region comprising three CDRs that are at least 90% identical to a group of three CDR regions selected from the group consisting of: a CDR1L region of SEQ ID NO: 741+m, a CDR2L region of SEQ ID NO: 889+m, and a CDR3L region of SEQ ID NO: 1037+m or SEQ ID NOs: 1205 and 1206, wherein m is a number selected from the group consisting of 0 to 147.

[0054] Preferably, the CDRs have at least 91%, preferably at least 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity with their corresponding SEQ ID NOs.

[0055] The most advantageous effects were found for the following antibodies or antigen-binding fragments: which comprise a VH region selected from the group comprising the following VH regions: a CDR1H region of SEQ ID NO: 297+n, a CDR2H region of SEQ ID NO: 445+n, and a CDR3H region of SEQ ID NO: 593+n, wherein n is a number selected from the group consisting of 0 to 147; and a VL region selected from the group comprising the following VL regions: a CDR1L region of SEQ ID NO: 741+m, a CDR2L region of SEQ ID NO: 889+m, and a CDR3L region of SEQ ID NO: 1037+m, or a CDR3L region of SEQ ID NO: 1205 or 1206, wherein m is a number selected from the group consisting of 0 to 147.

[0056] In another aspect of the invention, the antibody or antigen-binding fragment comprises a heavy chain variable (VH) region that is at least 85% identical to a VH region selected from the group consisting of the VH regions of SEQ ID NOs: 1 to 148 and the VH regions of SEQ ID NOs: 1185-1193.

[0057] The antibody according to the invention may further comprise a light chain variable (VL) region that is at least 85% identical to a VL region selected from the group consisting of the VL regions of SEQ ID NOs: 149 to 296 and the VL regions of SEQ ID NOs: 1194-1204.

[0058] Preferably, the antibody comprises a VH region that is at least 85% identical to the VH region of SEQ ID NO: 1+n and a VL region that is at least 85% identical to the VL region of SEQ ID NO: 149+m, wherein n and m are numbers selected from the group consisting of 0 to 147. Further preferably, the antibody comprises a VH region that is at least 85% identical to the VH region of SEQ ID NO: 1185-1193 and a VL region that is at least 85% identical to the VL region of SEQ ID NO: 1194-1204.

[0059] Further preferably, the antibody comprises a VH region that is at least 86% identical, preferably at least 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to the VH region of SEQ ID NO: 1+n or SEQ ID NO: 1185-1193, and a VL region that is at least 86% identical, preferably at least 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to the VL region of SEQ ID NO: 149+m or SEQ ID NO: 1194-1204, wherein n and m are numbers selected from the group consisting of 0 to 147.

[0060] Most preferably, such an antibody comprises a VH region selected from the group consisting of the VH regions of SEQ ID NO: 1+n and SEQ ID NOs: 1185-1193, and a VL region selected from the group consisting of the VL regions of SEQ ID NO: 149+m and SEQ ID NOs: 1194-1204, wherein n and m are numbers selected from the group consisting of 0 to 147.

[0061] In the above embodiments, n and m are preferably the same.

[0062] Particularly good results are achieved when the VH region is selected from the group consisting of SEQ ID NOs: 1 to 148 and SEQ ID NOs: 1185-1193 and the VL region is selected from the group consisting of SEQ ID NOs: 149 to 296 and SEQ ID NOs: 1194-1204.

[0063] Particularly preferred antibodies comprise one of the following combinations of six CDRs of the heavy and light chain sequences as shown in a single row of the following table representing SEQ ID NOs:

[0064] CDRH1 CDRH2 CDRH3 CDRL1 CDRL2 CDRL3 343 491 639 787 935 1083 444 592 740 888 1036 1184 397 545 693 841 989 1137 323 471 619 767 915 1063 309 457 605 753 901 1049 336 484 632 780 928 1076 310 458 606 754 902 1050 335 483 631 779 927 1075 388 536 684 832 980 1128 309 457 605 753 901 1205 335 483 631 779 927 1206

[0065] Advantageous effects of such antibodies are, for example, a particularly high selectivity for binding to human IL-1R7 and their potency in inhibiting IL-18 signaling. Figure 2 and Figure 3 IL-1R7 (but not IL-1R5) showed high specificity and selectivity. As an example, Figure 1 The efficiency in IL-18 signaling inhibition can be seen in the IL-18 signaling inhibition.

[0066] According to the present invention, the monoclonal antibody or antigen-binding fragment thereof is capable of binding to human IL-1R7 and exhibiting at least 30% inhibition of IL-18 signaling in an IL-18 functional assay as described in Example 1.

[0067] Preferably, the inhibition of IL-18 signaling is at least 35%, preferably at least 40%, 50%, 60%, 70%, 80% and most preferably at least 90% in an IL-18 functional assay.

[0068] In another embodiment according to the present invention, in the huIL-1R7 cell binding assay as described in Example 2, the monoclonal antibody or its antigen-binding fragment is capable of binding to human IL-1R7 and exhibits a binding specificity of greater than 10.000 RFU (relative fluorescence units) to cells expressing the human IL-1R7 receptor.

[0069] Preferably, the binding specificity is greater than 20.000 RFU, more preferably greater than 30.000 RFU, 40.000 RFU, 50.000 RFU, 60.000 RFU, 70.000 RFU, 80.000 RFU, 90.000 RFU, and most preferably greater than 100.000 RFU.

[0070] These values ​​illustrate the particularly high efficiency of the antibodies according to the invention in binding to the IL-1R7 receptor and inhibiting IL-18 signaling. This further highlights their effectiveness in treating diseases in which IL-18 signaling should be reduced.

[0071] As detailed in the Background, the IL-18 pathway is highly regulated and previous experience with direct IL-18 inhibition has produced conflicting results: pro-inflammatory effects of IL-18 activity involving signaling through IL-1R5 and IL-1R7 have been described. Potent anti-inflammatory effects of IL-37 activity involving signaling through IL-1R5 and another receptor, IL-1R8 (TIR8 / SIGIRR), have also been described. This suggests that IL-1R5 may serve not only as a receptor for IL-18, but also as a receptor for the anti-inflammatory cytokine IL-37, and that blockade of the IL-1R5 receptor may pose a risk to patients with reduced immune responses.

[0072] Thus, inhibition of IL-1R7 is a uniquely selective anti-inflammatory intervention without the risk of interference with other mechanisms that could be detrimental to patients treated with anti-IL-18 modalities.

[0073] Thus, it will be particularly appreciated in the art that the antibodies according to the present invention show very strong binding to the IL-1R7 receptor and very weak binding to the IL-1R5 receptor.

[0074] In the huIL-1R5 cell binding assay as described in Example 2, antibodies according to the present invention may exhibit binding specificity of less than 1.000 RFU to cells expressing the human IL-1R5 receptor.

[0075] Preferably, the binding specificity to cells expressing human IL-1R5 receptor is less than 1.000 RFU, 800 RFU, more preferably less than 700 RFU, 600 RFU, 500 RFU, 400 RFU, 300 RFU, 200 RFU, 100 RFU.

[0076] The monoclonal antibody according to the present invention may be a rabbit antibody. In a preferred embodiment, the antibody of the present invention is a rabbit / human chimeric antibody. In a further preferred embodiment, the antibody is a humanized antibody.

[0077] Figure 10 The amino acid sequences of several exemplary humanized antibodies are shown in . The most advantageous effects have been found with humanized antibodies having heavy chain variable regions (VH) shown in SEQ ID NOs: 1185-1193 and light chain variable regions (VL) shown in SEQ ID NOs: 1194-1204. Particularly preferred are humanized antibodies comprising one of the following combinations of heavy and light chain variable regions: VH of SEQ ID NO: 1185 and VL of SEQ ID NO: 1194; VH of SEQ ID NO: 1186 and VL of SEQ ID NO: 1195; VH of SEQ ID NO: 1187 and VL of SEQ ID NO: 1196; VH of SEQ ID NO: 1188 and VL of SEQ ID NO: 1197; VH of SEQ ID NO: 1189 and VL of SEQ ID NO: 1198; VH of SEQ ID NO: 1190 and VL of SEQ ID NO: 1199; VH of SEQ ID NO: 1191 and VL of SEQ ID NO: 1200; VH of SEQ ID NO: 1192 and VL of SEQ ID NO: 1201; VH of SEQ ID NO: 1193 and VL of SEQ ID NO: 1202; VH of SEQ ID NO: 1194 and VL of SEQ ID NO: 1203; VH of SEQ ID NO: 1195 and VL of SEQ ID NO: 1204; VH of SEQ ID NO: 1196 and VL of SEQ ID NO: 1205; VH of SEQ ID NO: 1197 and VL of SEQ ID NO: 1197; VH of SEQ ID NO: 1198 and VL of SEQ ID NO: 1198; VH of SEQ ID NO: 1199 and VL of SEQ ID NO: 1200; VH of SEQ ID NO: 1191 and VL of SEQ ID NO: 1201; VH of SEQ ID NO: 1192 and VL of SEQ ID NO: 1202; VH of SEQ ID NO: 1193 NO:1189 VH and SEQ ID NO:1203 VL; and SEQ ID NO:1192 VH and SEQ ID NO:1204 VL.

[0078] According to the preferred therapeutic application of the antibody of the present invention, the effector functions (such as ADCC, CDC and ADCP) of the antibody of the present invention are reduced or lack.Therefore, the antibody of the present invention avoids the unnecessary loss of immune cells and reduces the risk of adverse reactions such as opportunistic infections.

[0079] In one embodiment, an antibody according to the invention comprises one or more mutations that reduce interaction with an FcR receptor.

[0080] Preferably, the antibodies according to the invention exhibit reduced affinity for human Fcγ receptors compared to wild-type IgG Fcγ. This may result in reduced signaling through human Fcγ receptors compared to wild-type IgG Fcγ receptor signaling.

[0081] In a specific embodiment, an antibody according to the invention comprises amino acid substitutions at least at L234A and L235A in the human IgG1 Fc region. In another embodiment, the antibody may comprise amino acid substitutions at least at S228P and L235E in the human IgG4 Fc region.

[0082] Furthermore, the antibodies according to the present invention can be used for the treatment of IL-18 mediated diseases.

[0083] The purified preparations of the antibodies of the present invention can be mixed into pharmaceutical compositions for the treatment of human diseases and disorders such as those outlined below. Typically, such compositions further include pharmaceutically acceptable (i.e., inert) carriers as known and required by acceptable pharmaceutical practices. Examples of such carriers include sterile carriers, such as physiological saline Ringer's solution or dextrose solution, buffered to a pH in the range of 5 to 8 with suitable buffers. Pharmaceutical compositions for injection or continuous infusion are suitable for no visible particulate matter and can include 0.1 ng to 100 mg of antibody, typically between 5 mg and 35 mg of antibody. In many cases, pharmaceutical compositions according to the present invention include a pharmaceutically acceptable carrier and a therapeutically effective amount of an antibody according to the present invention. Methods for preparing such pharmaceutical compositions are well known to those skilled in the art.

[0084] The effective dose and treatment method for administering the antibodies of the present invention are generally determined empirically and depend on factors such as the patient's age, weight, and health status, as well as the disease to be treated. Such factors are within the jurisdiction of the attending physician. Typically, they are between 1 mg and 1000 mg. In one embodiment, the dosage regimen for treating human patients is to administer intravenously (iv) or subcutaneously (sc) once a week, once every four weeks, or once every three months. The compositions of the present invention can also be used once or even prophylactically.

[0085] Depending on the disease or condition to be treated, a pharmaceutical composition containing a therapeutically effective amount of an antibody of the present invention can be used simultaneously, separately or sequentially with an effective amount of another agent, such as other anti-inflammatory or anti-tumor agents.

[0086] The disease to be treated with the antibody or pharmaceutical composition according to the present invention may be an immune disease or an autoimmune disease or an inflammatory or autoinflammatory disease or a cardiovascular disease. The disease may also be an inflammasome-mediated disease.

[0087] The disease to be treated with the antibody or pharmaceutical composition according to the present invention may be a disease selected from the group consisting of type 1 or 2 diabetes, inflammatory bowel disease, Crohn's disease (CD); ulcerative colitis (UC), multiple sclerosis, sarcoidosis, giant cell arteritis (GCA), age-related macular degeneration (AMD), chronic obstructive pulmonary disease (COPD), adult-onset Still's disease (AOSD), systemic juvenile idiopathic arthritis (SJIA), severe asthma, uveitis, geographic atrophy, atherosclerosis and tumor-induced chronic inflammation.

[0088] The present invention also includes methods of treating IL-18-mediated diseases in a patient. Such methods comprise administering to the patient a pharmaceutically effective amount of an antibody or pharmaceutical composition according to the present invention.

[0089] The method can be applied in cases where patients do not respond to anti-TNF therapy.

[0090] The method may also be used to treat immune or autoimmune diseases or inflammatory or autoinflammatory diseases or cardiovascular diseases.Inflammasome-mediated diseases may also be treated using the method according to the invention.

[0091] In another aspect of the invention, the disease treated by the present method is a disease selected from the group consisting of: type 1 or 2 diabetes, inflammatory bowel disease, Crohn's disease (CD); ulcerative colitis (UC), multiple sclerosis, sarcoidosis, giant cell arteritis (GCA), age-related macular degeneration (AMD), chronic obstructive pulmonary disease (COPD), adult-onset Still's disease (AOSD), systemic juvenile idiopathic arthritis (SJIA), severe asthma, uveitis, geographic atrophy, atherosclerosis, and tumor-induced chronic inflammation.

[0092] Example

[0093] The following examples, taken in conjunction with the figures and tables, illustrate the invention.

[0094] Example 1: IL-18 functional analysis

[0095] 1. Culture HEK-Blue according to the manufacturer's instructions TM cells (InvivoGen; Cat. no.: hkb-hmil18).

[0096] 2. Place 12.5k HEK-Blue cells cultured in 15 μL of culture medium per well. TM The cells were removed and placed into flat-bottomed clear cell culture treated 384-well plates.

[0097] 3. Add 5 μL of B cell supernatant or a standard antibody dilution series to each well.

[0098] 4. Incubate at 37°C / 5% CO2 for 1 hour.

[0099] 5. Add 5 μL of 0.1 mg / ml huIL-18 solution to each well.

[0100] 6. Incubate at 37°C / 5% CO2 overnight.

[0101] 7. Add 20 μL of QUANTI-Blue TM (1 sachet dissolved in 50 ml) onto a new clear non-binding plate.

[0102] 8. Add 5 μL HEK-Blue TM The cells were supernatanted and incubated at 37°C / 5% CO2 for 45 minutes.

[0103] 9. Determine SEAP levels using a spectrophotometer at 620-655 nm.

[0104] Example 2: huIL-1R7 and huIL-1R5 Cell Binding Assay

[0105] 1. Seed sufficient number of HEK293 cells (1,000 to 2,000 cells / well) transfected with huIL-1R7 or huIL-1R5 in 20 μl of culture medium into a clear-bottom black 384-well plate.

[0106] 2. Incubate the plate at 37°C and 5% CO2 for 4 hours.

[0107] 3. Add 5 μL of B cell supernatant or a standard antibody dilution series to each well.

[0108] 4. Incubate the plate overnight at 37°C and 5% CO2.

[0109] 5. Wash the plate three times with 25 μL PBS and add 20 μL of the appropriate detection antibody (assay concentration 0.8 μg / ml).

[0110] 6. Incubate the plate in the dark at 37°C and 5% CO2 for 4 hours.

[0111] 7. Add 5 μl of 25 μg / ml Hoechst solution and cover with aluminum foil. Incubate the cells at room temperature for 10 minutes and then centrifuge the plate at 300 x g for 10 seconds.

[0112] 8. Use CellInsight TM High-content screening platform analyzes antibody binding to cells.

[0113] Example 3: Biochemical human IL1R7 ELISA

[0114] The binding of humanized anti-IL1R7-IgG1-LALA monoclonal antibody to human IL1R7 protein was tested in a biochemical ELISA. TM MaxiSorp TM The plate was cultured with recombinant human IL1R7-Fc protein (MAB Discovery) at a concentration of 0.5 μg / ml in PBS for 1 hour. After washing 3 times with wash buffer (PBS, 0.1% Tween), the plate was blocked with PBS, 2% BSA, 0.05% Tween for 1 hour at room temperature. After washing the plate 3 times with wash buffer again, the antibody with a concentration range of 10 μg / ml to 6 pg / ml was cultured for 1 hour in PBS, 0.5% BSA, 0.05% Tween at room temperature. After washing 3 times with wash buffer, the wells were cultured with 12.5 μl of 1:5000 diluted anti-human peroxidase-linked, species-specific F (ab) 2 fragment (AbD Serotec) from goats in ELISA buffer for 1 hour at room temperature. The wells were washed 6 times with wash buffer and 15 μl / well TMB substrate solution (Invitrogen) was added. After 30 minutes at room temperature, 15 μl of stop solution (1 M HCl) was added to each well and the absorbance at 450 and 620 nm was measured using a Tecan M1000 microplate reader. The fitting curve and EC50 calculation value were obtained by using Excel (Microsoft) and XLfit (IDBS). Figure 5 As shown in , the EC50 binding values ​​ranged from 2.1 ng / ml to 4.5 ng / ml.

[0115] Example 4: Cell Binding to hIL1R7-Expressing Cells

[0116] In order to determine the effectiveness of humanized anti-IL1R7 IgG1-LALA monoclonal antibody in binding to human IL1R7 expressed by cells, HEK-293 cells were transfected with DNA encoding human IL1R7. After 48 hours of transfection, 2000 cells were seeded in 20 μl of DMEM containing 10% FBS, 1x Pen / Strep in a cell culture-treated, transparent-bottomed 384-well plate. Antibodies were added to 5 μl culture medium to reach a final concentration in the range of 10 μg / ml to 2 pg / ml. After 24 hours, cells were washed 3 times with 25 μl wash buffer (PBS, 0.05% Tween), and then Alexa-Fluor-488-conjugated goat anti-human IgG (Jackson Laboratories) was added in 20 μl culture medium at a concentration of 0.8 μg / ml. After 4 hours, 5 μl Hoechst dye was added to the culture medium to reach a final concentration of 5 μg / ml. Fluorescent cell binding signals were measured using the CellInsight automated high-content imager (ThermoFisher Scientific). Fitting curves and EC50 calculations were obtained using Excel (Microsoft) and XLfit (IDBS). Figure 6 As shown in , EC50 binding values ​​ranged from 1.7 to 8.3 ng / ml.

[0117] Example 5: Neutralization of IL-18-induced NF-κB signaling

[0118] Using HEK-Blue-IL18 TM The ability of the humanized monoclonal α-IL1R7IgG1-LALA antibody to interfere with IL-18-induced NF-κB signaling was tested by reporter cells (InvivoGen). Cells were seeded in 15 μl DMEM, 10% FCS, 1% Pen / Strep in a 384-well tissue culture plate at a cell density of 12,500 cells / well. Antibodies were added to reach a final antibody concentration of 50 to 0.024 μg / ml and cultured for 1 hour. Human IL-18 was added to reach a final concentration of 100 pg / ml and the cells were cultured for 24 hours. 5 μl of the culture supernatant from each well was transferred to a plate containing 20 μl of 2x QUANTI-Blue TM The cells were plated in a white, clear-bottomed 384-well plate containing the 5% phosphatase inhibitor (InvivoGen). After incubation for 45 minutes at 37°C and 5% CO2, the optical density at a wavelength of 655 nm, reflecting NF-κB-dependent activation of phosphatase secretion, was measured. Fitting curves and EC50 calculations were generated using Excel (Microsoft) and XLfit (IDBS). Figure 7The EC50 values ​​shown in Figure 5 indicate that anti-IL1R7 antibodies can be used to inhibit the expression of IL1R7 in HEK-Blue-IL18 cells. TM Efficacy of inducing NF-kB signaling in reporter cells.

[0119] Example 6: Neutralization of IL-18-induced IL-6 cytokine release

[0120] The ability of the anti-IL1R7IgG1-LALA antibody of humanized monoclonal inhibition IL-19 induced IL-6 cytokine release was tested with hIL-18 stimulation A-549_IL18Rb_IL1R9 cells. Cells were seeded in F-12K nutrient mixture Kaighn's modified medium + 10% FCS in 384-well cell culture plates at a density of 12500 cells / well. After 24 hours, cells were washed 3 times with cell wash buffer (PBS, 0.05% Tween) and 15 μl culture medium and 10 μl antibody were added to reach a final antibody concentration of 33.3 to 0.016 μg / ml. After 1 hour, human IL18 was added to reach a final concentration of 10 ng / ml and cells were cultured for 6 hours. The IL-6 concentration in the quantified cell culture supernatant was determined using the human-IL6 DuoSet ELISA kit from R&D Systems. Fitting curves and EC50 calculated values ​​were obtained using Excel (Microsoft) and XLfit (IDBS). Figure 8 EC50 values ​​ranging from 133 to 6350 ng / ml were summarized.

[0121] Example 7: Neutralization of IL-18-induced IFN-γ release

[0122] The ability of humanized monoclonal anti-IL1R7 IgG1-LALA antibody to inhibit the release of IFN-γ induced by IL-18 was tested using KG-1 myeloblasts. KG-1 cells were seeded in 15 μl of RPMI 1640 culture medium containing 20% ​​FBS and 2mM L-glutamine in 384-well cell culture plates at a density of 6750 cells / well. Antibodies were added to reach a total concentration of 1.4 μg / ml or in the range of 5000 to 0.03 ng / ml for dose titration experiments. After culturing for 1 hour, human IL-18 (final concentration 5 ng / ml) and TNF-α (final concentration 10 ng / ml) were added and the cells were cultured for 48 hours at 37°C and 5% CO2. The IFN-γ concentration in the culture supernatant was quantified using the human-IFN-γ ELISA kit from R&D Systems. Figure 9 A summarizes the IFN-γ concentrations measured after treatment of KG-1 cells with 1.4 μg / ml of antibody. Figure 9B shows the EC50 inhibition values ​​of IFN-γ release determined in the dose titration experiment. Fitting curves and EC50 calculations were obtained using Excel (Microsoft) and XLfit (IDBS). BRIEF DESCRIPTION OF THE DRAWINGS

[0123] Figure 1 :IL-18 functional analysis

[0124] Results of experiments performed as detailed in Example 1 are shown.

[0125] Figure 2 :huIL-1R7 cell binding assay

[0126] The results of an experiment performed according to Example 2 are shown.

[0127] Figure 3 :huIL-1R5 cell binding assay

[0128] Results of experiments performed as detailed in Example 2 are shown.

[0129] Figure 4 : Sequence (amino acids are represented by single-letter codes)

[0130] The complete sequence of the variable region (VR):

[0131] Heavy chain: VH complete: SEQ ID NO: 1-148

[0132] Light chain: VL complete: SEQ ID NO: 149-296

[0133] Complementarity determining regions (CDRs):

[0134] Heavy chain: CDR-H1: SEQ ID NO: 297-444

[0135] CDR-H2: SEQ ID NO: 445-592

[0136] CDR-H3: SEQ ID NO:593-740

[0137] Light chain: CDR-L1: SEQ ID NO: 741-888

[0138] CDR-L2: SEQ ID NO:889-1036

[0139] CDR-L3: SEQ ID NO:1037-1184,1205,1206

[0140] Figure 5: Binding of human α-IL1R7 antibody to human IL-1R7 in biochemical ELISA

[0141] Shown are the results of an experiment performed as detailed in Example 3. The humanized anti-IL-1R7 IgG1-LALA antibody was tested for binding to recombinant human IL-1R7 protein in a biochemical ELISA. EC50 binding values ​​ranged from 2.1 ng / ml to 4.5 ng / ml.

[0142] Figure 6 : Binding of humanized α-IL1R7 antibody to HEK-293-hIL1R7 cells

[0143] The results of experiments performed as detailed in Example 4 are shown. HEK-293 cells transfected with DNA encoding human IL1R7 were used to test the binding of humanized anti-IL-1R7 IgG1-LALA antibody to cell surface expressed human IL1R7. EC50 binding values ​​ranged from 1.7 ng / ml to 8.3 ng / ml.

[0144] Figure 7 : IL-18-induced HEK-Blue-IL18 TM Neutralization of NF-kB signaling in reporter cell lines

[0145] Shown are the results of an experiment performed as detailed in Example 5. HEK-Blue-IL18 was stimulated with 100 pg / ml human IL-18 TM Reporter cells were treated with increasing concentrations of the humanized monoclonal α-IL1R7IgG1-LALA antibody, which interfered with IL-18-induced NF-κB signaling with inhibition EC50 values ​​ranging between 3.2 and >50 μg / ml.

[0146] Figure 8 :Neutralization of IL18-induced IL-6 release by A-549_IL18Rb_IL1R9 cells

[0147] The results of an experiment performed as described in detail in Example 6 are shown. Neutralization of IL-18-induced IL-6 secretion was tested using A-549_IL18Rb_IL1R9 cells. Cells were cultured for 6 hours with increasing concentrations of humanized monoclonal α-IL1R7 IgG1-LALA antibody or reference mouse-α-hIL1R7 antibody (MAB1181) from R&D Systems and 10 ng / ml IL-18. IL-6 release in the cell supernatant was quantified by ELISA.

[0148] Figure 9Neutralization of IL-18-induced IFN-g release by KG-1 myeloblasts

[0149] Shown are the results of experiments performed as detailed in Example 7. KG-1 myeloblasts were treated with increasing concentrations of the humanized monoclonal α-IL1R7 IgG1-LALA antibody or the reference mouse-α-hIL1R7 antibody (MAB1181) from R&D Systems to test their ability to block hIL-18-induced IFN-γ release. Figure 9 A shows the inhibition of IFN-γ release at an antibody concentration of 1.4 μg / ml. Figure 9 Inhibition EC50 values ​​from antibody dose titration experiments (5000 to 0.03 ng / ml) are shown in B.

[0150] Figure 10 : Sequence of humanized antibody

[0151] The complete sequence of the variable region and each CDR Sequence Listing <110> MAB Discovery GmbH <120> Antibodies that specifically bind to human IL-1R7 <130> 65660P WO <150> EP 17160191.7 <151> 2017-03-09 <160> 1206 <170> PatentIn version 3.5 <210> 1 <211> 119 <212> PRT <213> Rabbit <400> 1 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Ile Ser Gly Ile Asp Leu Ser Ala Tyr Ala 20 25 30 Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Gly Ile Ala Asn Asn Gly Pro Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Ile Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Pro 85 90 95 Pro Gly Thr Asn Gly Gly Thr Asp Tyr Phe Asn Ile Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Leu 115 <210> 2 <211> 114 <212> PRT <213> European rabbit <400> 2 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Val Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Gly Tyr Asp 20 25 30 Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Met Ile Tyr Pro Asn Ser Gly Thr Asn Tyr Ala Thr Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Pro Thr Thr Val Ala Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser 85 90 95 Gly Trp Gly Ala Phe Asp Pro Trp Gly Pro Gly Thr Leu Val Thr Ile 100 105 110 Ser Ser <210> 3 <211> 119 <212> PRT <213> European rabbit <400> 3 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Ala 20 25 30 Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Gly Ile Ser Asn Ser Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Ile Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Pro 85 90 95 Pro Gly Ser Asn Ser Gly Thr Asp Tyr Phe Asn Ile Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Leu 115 <210> 4 <211> 113 <212> PRT <213> European rabbit <400> 4 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Gly Leu Val 20 25 30 Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Val Ile Gly Lys Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Ser Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Ile 65 70 75 80 Ala Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg Asn 85 90 95 Ile Ser Gly Ser Ala Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser 100 105 110 Leu <210> 5 <211> 126 <212> PRT <213> European rabbit <400> 5 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Trp Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Val Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Glu Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Leu Gly Ala Gly Tyr Ala Gly Tyr Gly Tyr Ala Ser Asp 100 105 110 Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 6 <211> 119 <212> PRT <213> European rabbit <400> 6 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ile Tyr Ala 20 25 30 Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Gly Ile Gly Asn Asn Gly Ile Ile His Tyr Ala Asn Trp Ala Lys Gly 50 55 60[[ID=,15]] Arg Phe Thr Ser Ser Lys Ile Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Pro 85 90 95 Pro Gly Ser Asn Ser Gly Thr Asp Tyr Phe Asn Ile Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Leu 115 <210> 7 <211> 118 <212> PRT <213> European rabbit <400> 7 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Cys Ile Tyr Gly Gly Ser Ser Gly Lys Thr Trp Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Asn Tyr Asp Trp Tyr Phe Asn Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 8 <211> 119 <212> PRT <213> European rabbit <400> 8 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Met Tyr Ala 20 25 30 Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Gly Ile Ala Asn Asn Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Ile Ser Thr Thr Val Asp Leu Arg Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Pro 85 90 95 Pro Gly Ser Asn Ser Gly Thr Asp Tyr Phe Asn Ile Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Leu 115 <210> 9 <211> 124 <212> PRT <213> European rabbit[[ID=3M]] <400> Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Leu Ser Ser Tyr Tyr 20 25 30 Tyr Met Cys Trp Phe Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Ala Asp Asp Ala Thr Thr Tyr Tyr Ala Thr Trp Ala 50 55 60 Lys Gly Arg Phe Thr Val Ser Ile Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Pro Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Arg Asp Ala Asp Tyr Val Gly Phe Ile Trp Ala Tyr Tyr Phe Asn 100 105 110 Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 10 <211> 113 <212> PRT <213> European rabbit <400> 10 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Asn Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Arg Asn Thr Gly Thr Thr Trp Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Asn 85 90 95 Pro Gly Trp Ala Ser Thr Trp Gly Pro Gly Thr Leu Val Thr Val Ser 100 105 110 Ser <210> 11 <211> 124<"0000631"><212> PRT <213> European rabbit <400> 11 Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ala 1 5 10 15<"0000636">Ser Leu Thr Leu Thr Cys Lys Thr Ser Gly Phe Ser Phe Ser Asp Asn 20 25 30 Tyr Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Tyr Val Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Gln Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr His Phe Cys [[ID=4,6]] 85 90 95 Note: The text seems to be some kind of biological sequence or related information with specific formatting. The translation of "穴兔" as "European rabbit" is a common translation in the context of biology for this species. Also, the tags and were left as they were in the original as they might be specific identifiers in a particular system and the exact meaning is not clear without further context. Ala Arg Gly Val Val Ile Gly Asn Ala Tyr Ser Met Ala His Phe Ser 100 105 110 Leu Trp Gly Ser Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 12 <211> 125 <212> PRT <213> European rabbit <400> 12 Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Cys Ile Tyr Thr Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Arg Leu Asn Tyr Val Thr Tyr Pro Ala Tyr Gly Tyr Gly Tyr Phe 100 105 110 Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 13 <211> 121 <212> PRT <213> European rabbit <400> 13 Gln Glu Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Asn Gly Asn 20 25 30 Tyr Tyr Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 65 70 75 80 Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 85 90 95 Cys Val Arg Asp Lys Pro Ala Gly Gly Ser Ser Tyr Thr Leu Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 14 <211> 120 <212> PRT <213> European rabbit <400> 14 Gln Glu Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Arg Ser 20 25 30 Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Tyr Ala Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Ser 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 65 70 75 80 Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 85 90 95 Cys Ala Arg Gly Gly Gly Ile Ile Tyr Thr Gln Asn Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 15 <211> 124 <212> PRT <213> European rabbit <400> 15 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Val Ser Met Tyr 20 25 30 Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Thr Gly Ser Ser Gly Lys Thr His Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Ser Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Leu Tyr Ser Cys 85 90 95 Ala Arg Ala Gly Ser Val Gly Tyr Gly Tyr Asp Thr Ala Tyr Phe Asn 100 105 110 Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 16 <211> 114 <212> PRT <213> European rabbit <400> 16 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15<着 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Asp 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Ile Ile Tyr Asp Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ala Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Thr Leu 85 90 95 Asn Thr Leu Pro Phe Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val 100 105 110 Ser Leu <210> 17 <211> 120 <212> PRT <213> European rabbit <400> 17 Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Ala Ala Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Leu Gly Asp Asp Gly Tyr Ala Tyr Gly Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 18 <211> 120 <212> PRT <213> European rabbit <400> 18 Gln Ser Leu Glu Glu Ser Gly Gly Val Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Phe Ser Ser Ser Tyr 20 25 30 Tyr Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Gly Thr Gly Ser Ser His Tyr Thr Ser Asn Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 19 <211> 120 <212> PRT <213> European rabbit <400> 19 Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Asp Gly 20 25 30 Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Cys Ile Tyr Thr Gly Pro Gly Gly Thr Phe Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Leu Asn Gly Ala Asp Ser Gly Ser Ala Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 20 <211> 116 <212> PRT <213> European rabbit <400> 20 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala 20 25​​​​​​​​​​​​​​​​​​​​​​​​​<210> 21 <211> 120 <212> PRT <213> European rabbit <400> 21 Gln Glu Gln Leu Lys Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Asn Tyr 20 25 30 Gln Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 35 40 45 Gly Phe Ile Lys Ala Asp Gly Ser Ala Tyr Tyr Ala Asn Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Ala Val Thr Leu Ser Leu 65 70 75 80 Thr Thr Pro Thr Thr Gly Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 85 90 95 Phe Tyr Ala Gly Ser Ser Gly Asn Val Asn Gly Asp Ile Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Leu 115 120 <210> 22 <211> 119 <212> PRT <213> European rabbit <400> 22 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Met Tyr Ala 20 25 30 Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Gly Ile Ala Thr Asn Gly Ile Ile His Tyr Ala Ser Trp Val Lys Gly 50 55 60 Gln Phe Thr Ile Ser Lys Ile Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg Phe Pro 85 90 95 Pro Gly Ser Asn Gly Gly Thr Ala Tyr Phe Asn Ile Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Leu 115 <210> 23 <211> 114 <212> PRT <213> European rabbit <4​​​​​Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Asp 20 25 30 Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Met Ile Tyr Pro Asn Ser Gly Thr Asn Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Pro Thr Thr Val Ala Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser 85 90 95 Gly Trp Gly Ala Phe Asp Pro Trp Gly Pro Gly Thr Leu Val Thr Val 100 105 110 Ser Ser <210> 24 <211> 114 <212> PRT <213> European rabbit <400> 24 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Asp 20 25 30 Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Met Ile Tyr Pro Asn Gly Gly Thr Asn Tyr Ala Thr Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Pro Thr Thr Val Ala Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser 85 90 95 Gly Trp Gly Ala Phe Asp Pro Trp Gly Pro Gly Thr Leu Val Thr Val 100 105 110 Ser Ser <210> 25 <211> 112 <212> PRT <213> European rabbit <400> 25 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Asn Ala 20 25 30 Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Tyr Ala Ser Asp Ser Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Met Thr 65 70 75 80 Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr 85 90 95 Ser Asp Ile Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Leu 100 105 110 <210> 26 <211> 119 <212> PRT <213> European rabbit <400> 26 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Met Tyr Thr 20 25 30 Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Gly Ile Ala Thr His Gly Ile Ile His Tyr Ala Ser Trp Val Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Ile Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Pro 85 90 95 Pro Gly Ser Asn Gly Gly Thr Ala Tyr Phe Asn Ile Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Leu 115 <210> 27 <211> 121 <212> PRT <213> European rabbit <400> 27 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Asn Ser 20 25 30 Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 35 40 45 Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val Asp Leu Lys Ile 65 70 75 80 Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Lys Gly 85 90 95 Leu Gly Arg Gly Glu Tyr Thr Ser Asn Asp Ala Phe Asp Pro Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120[[ID=4​​​​​​​ <400> 28 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Thr Ser Thr Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 35 40 45 Gly Cys Ile Val Thr Gly Arg Gly Asn Thr Tyr Tyr Ala Asn Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Gly Ser Ser Asp Glu Ile Ala Leu Asp Leu Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 29 <211> 118 <212> PRT <213> European rabbit <400> 29 [[ID= forty-five]]Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Ala Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Ala 20 25 30 Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Phe Ile Asn Ile Ile His Gly Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Pro 85 90 95 Tyr Tyr Val Gly Ser Glu Tyr Val Phe Asp Pro Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 30 <211> 118 <212> PRT <213> European rabbit <400> 30 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser His Ala 20 25 30 Note: There seems to be a small error in the original text where "穴兔" which is Chinese for "European rabbit" is not translated correctly in the previous version. I've corrected it in the translation above.Thr Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Phe Ile Lys Thr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Ala Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Met Phe 85 90 95 Tyr Ala Gly Asp Ser Gly His Tyr Leu His Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 31 <211> 108 <212> PRT <213> European rabbit <400> 31 Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Gly 20 25 30 Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Tyr Ile Asn Thr Gly Gly Ser Ala Ser Tyr Ala Thr Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ala Asn Asn 85 90 95 Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 100 105 <210> 32 <211> 120 <212> PRT <213> European rabbit <400> 32 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Asn Tyr 20 25 30 Tyr Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Thr Gly Ser Thr Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Tyr Ser Tyr Gly Gly Ala Val Ser Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 33 <211> 116 <212> PRT <213> European rabbit <400> 33 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr Ala 20 25 30 Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Ser Asn Ser Gly Ala Thr Ala Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Thr Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Arg 85 90 95 Ser Gly Gly Trp Asp Ala Leu Asp Pro Trp Gly Pro Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 34 <211> 122 <212> PRT <213> European rabbit <400> 34 Gln Glu Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Gly Thr Ser Ser Thr Ile Ser Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Arg Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Glu Asp Tyr Ala Gly Gly Thr Asp Tyr Tyr Phe Arg Leu Trp 100 105 110 Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 35 <211> 116 <212> PRT <213> European rabbit <400> 35 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile His Tyr Ser Gly Tyr Ile Ala Tyr Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly 85 90 95 Asp Ala Asp Asn Phe Tyr Tyr Asn Ile Trp Gly Pro Gly Thr Leu Val 100 105 110 [[ID=�9]]Thr Val Ser Leu 115 <210> 36 <211> 120 <212> PRT <213> European rabbit <400> 36 Gln Glu Gln Leu Lys Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Asn Tyr 20 25 30 Gln Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 35 40 45 Gly Phe Ile Lys Pro Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Thr Leu Lys Leu 65 70 75 80 Thr Ser Pro Thr Thr Gly Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 85 90 95 Phe Tyr Ala Gly Ser Ser Gly Asn Val Asn Gly Asp Ile Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Leu 115 120 <210> 37 <211> 116 <212> PRT <213> European rabbit <400> 37<00011​​​​Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Thr Tyr 20 25 30 Trp Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Asp Gly Gly Ser Ser Gly Ile Thr Gly Tyr Ala Asn Trp 50 55 60 Ala Lys Gly Arg Phe Thr Leu Ser Arg Thr Ser Ser Thr Ala Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Glu Leu Asp Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 38 <211> 120 <212> PRT <213> European rabbit <400> 38 Gln Glu Gln Leu Lys Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr 20 25 30 Gln Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 35 40 45 Gly Phe Ile Asn Thr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Ile Ile 65 70 75 80 Thr Ser Pro Thr Thr Gly Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 85 90 95 Phe Tyr Ala Gly Ser Ser Gly Asn Val Asn Gly Asp Ile Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Leu 115 120 <210> 39 <211> 119 <212> PRT <213> European rabbit <400> 39 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Gly Ala Gly Ser Asn Gly Asp Phe Asn Leu Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 40 <211> 120 <212> PRT <213> European rabbit <400> 40 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Asn Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Gly Ala Gly Ser Tyr Gly Gly Ala Val Arg Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 41 <211> 121 <212> PRT <213> European rabbit <400> 41 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Glu Gly Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile His Ala Gly Ser Ser Gly Ala Ala Tyr Tyr Ala Thr Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val Thr 65 70 75 80 Leu His Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Val Arg Asp Gly Tyr Asp Asp Tyr Gly Asp Pro Phe Asn Leu Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 42 <211> 118 <212> PRT <213> European rabbit <400> 42<00^01278>Gln Ser Val Glu Glu Ser Gly Gly His Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Trp Ile 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Thr Thr Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ile Ser 85 90 95 Ala Gly Ser Asp Ser Tyr Ile Ile Asp Asn Ile Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Leu 115 Note: There seems to be an error in the original text where <00^01278> is likely a misformatting. I've translated it as in the translation for consistency. Also, the name "穴兔" is translated as "European rabbit" which is a common English name for the species, but it might need to be adjusted according to the specific context. <210> 43 <211> 120 <212> PRT <213> European rabbit <400> 43 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Thr Tyr 20 25 30 Ser Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Cys Ile Tyr Thr Gly Ser Ser Gly Gly Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Gly 65 70 75 80 Leu Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Ala Gly Asn Ser Gly Tyr Tyr Ile Asn Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 44 <211> 112 <212> PRT <213> European rabbit <400> 44 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser Ser Gly Tyr 20 25 30<00013{24}>Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Ala Cys Ile Tyr Thr Val Asn Asp Asn Thr Trp Tyr Ala Ser Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Leu Tyr Lys Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 100 105 110 <210> 45 <211> 120 <212> PRT <213> European rabbit <400> 45 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Tyr Phe Ser Ser Thr Tyr 20 25 30 Tyr Thr Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Val Asp Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Ser Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Val Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Gly Arg Pro Tyr Val Gly Tyr Gly Tyr Ala Thr Asp Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 46 <211> 116 <212> PRT <213> European rabbit <400> 46 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Ala 20 25 30 Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 It should be noted that the "穴兔" in Chinese is translated as "European rabbit" here, but it may be more accurately translated as "Oryctolagus cuniculus" which is the scientific name of the European rabbit. Also, the tag in the original seems to have a wrong encoding, it should probably be .Tyr Ile Ser Thr Ser Gly Thr Pro Tyr Tyr Ala Ser Trp Val Asn Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser 85 90 95 Tyr Ala Gly Asp Tyr Ala Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 47 <211> 114 <212> PRT <213> European rabbit <400> 47 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Asp 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Ile Ile Tyr Asn Ser Gly Thr Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ala Lys Thr Ser Thr Thr Val Asn Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Thr His 85 90 95 Asn Thr Leu Pro Phe Tyr Ile Trp Gly Pro Gly Thr Leu Val Thr Val 100 105 110 Ser Leu <210> 48 <211> 119 <212> PRT <213> European rabbit <400> 48 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Glu Gly Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Thr Tyr 20 25 30 Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Thr Asp Ser Ser Thr Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Gly Ser Gly Gly Ser Asp Tyr Phe Asn Leu Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 49 <211> 121 <212> PRT <213> European rabbit <400> 49 Gln Glu Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Val Gly Gly Gly Gly Val Asn Thr Tyr Tyr Ala Asn 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 65 70 75 80 Thr Leu Glu Met Thr Ser Leu Thr Val Ala Asp Thr Ala Thr Tyr Phe 85 90 95 Cys Ala Arg Asp Leu Gly Ala Asp Gly Tyr Ala Tyr His Leu Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 50 <211> 121 <212> PRT <213> European rabbit <400> 50 Gln Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu Ser 1 5 10 15 Leu Lys Leu Ser Cys Lys Ala Ser Gly Ile Asp Phe Ser Ser Asp Gly 20 25 30 Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Ile Ala 35 40 45 Phe Ile Tyr Pro Gly Val Gly Ile Thr His Tyr Ala His Ser Val Lys 50 55 60 Gly Arg Leu Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Phe Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ser Asp Thr Ala Thr Tyr Phe Cys Val 85 90 95 Arg Asp Pro Ile Tyr Asp Asp Tyr Gly Gly Arg Leu Asp Leu Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 51 <211> 119 <212> PRT <213> European rabbit <400> 51 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 20 25 30 Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Gly Val Ala Asn Asn Gly Ile Thr Asn Tyr Ala Ser Trp Ala Arg Gly 50 55 60 Arg Phe Thr Ile Ser Lys Ile Ser Thr Thr Val Asp Leu Lys Ile Ile 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Pro 85 90 95 Pro Gly Ser Asn Gly Gly Thr Asp Tyr Phe Asn Ile Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Leu 115 <210> 52 <211> 116 <212> PRT <213> European rabbit <400> 52 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Asn Ala 20 25 30 Leu Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Tyr Ile Ser Thr Gly Gly Ser Ala Tyr Tyr Ala Thr Trp Val Asn Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 65 70 75 80 Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser 85 90 95 Tyr Ala Gly Asp Tyr Ala Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 53 <211> 114 <212> PRT <213> European rabbit <400> 53 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Asp 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Ile Ile Tyr Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ala Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ala Arg 85 90 95 Asn Thr Leu Pro Phe Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val 100 105 110 Ser Leu <210> 54 <211> 119 <212> PRT <213> European rabbit <400> 54 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15<00​​​​​​​​​​​​Arg Phe Thr Ile Ser Lys Val Ser Thr Ser Val Pro Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Leu 85 90 95 Tyr Ser Ala Ser Gly Trp Ser Tyr Cys Phe Asp Ile Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Leu 115 <210> 55 <211> 118 <212> PRT <213> European rabbit <400> 55 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Val Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Thr Phe Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Ala Thr Gly Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Asp 85 90 95 Phe Leu Val Gly Leu Thr Tyr Ala Gly Val Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 56 <211> 118 <212> PRT <213> European rabbit <400> 56 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Ser Thr Tyr Gly 20 25 30 Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Tyr Ile Asn Ile Tyr Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys Ser 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asn Gly 85 90 95 Ala Ser Gly Thr Tyr Tyr Ser Ser Leu Tyr Ile Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Leu 115 <210> 57 <211> 119 <212> PRT <213> European rabbit <400> 57 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Met Tyr Ala 20 25 30 Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Gly Ile Ala Asn Asn Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Ile Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Pro 85 90 95 Pro Gly Ser Asn Ser Gly Thr Asp Tyr Phe Asn Ile Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Leu 115 <210> 58 <211> 111 <212> PRT <213> European rabbit <400> 58 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Ile Ile Ser Ser Ser Gly Asn Ser Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Val Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Gly Gly Ser 85 90 95 Gly Trp Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser [[ID=3x]]100 105 110 <210> 59 <211> 115 <212> PRT <213> European rabbit <400> ५9 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 1 5 10 15 Note: It seems there is an incorrect "५9" in the original text which I've left as-is in the translation. Also, the "穴兔" is translated as "European rabbit" as it's a more common English name for the species. If there's a specific correct English name for it you want to use instead, please let me know.Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 20 25 30 Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Ile Ile Ser Ser Gly Leu Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 50 55 60 Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr Ser 65 70 75 80 Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Leu Gly 85 90 95 Ala Ala Ser Ala Thr Trp Asp Ile Trp Gly Pro Gly Thr Leu Val Thr 100 105 110 Val Ser Leu 115 <210> 60 <211> 120 <212> PRT <213> European rabbit <400> 60 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Ala Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Asn Phe Gly Arg Ser Gly Asn Ile Tyr Tyr Ala Arg Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Lys Ala Gly Asp Ser Tyr Tyr Phe Asn Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 61 <211> 112 <212> PRT <213> European rabbit <400> 61 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Asn Asn Tyr Tyr 20 25 30 Met Thr Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Tyr Ile Gly [[ID=4!]]35 40 45 Phe Ile Asp Pro Tyr Ser Ser Pro Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 It seems there is a minor error in your input where "4!" should probably be "43". I've translated it as is but you may want to correct that in the original for a more accurate result.Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Ile Ser 65 70 75 80 Ser Pro Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Val 85 90 95 Ala Val Gly Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Leu 100 105 110 <210> 62 <211> 112 <212> PRT <213> European rabbit <400> 62 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr His 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Val Ile Tyr Gly Ser Gly Ser Ala Trp Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Gly Ile 85 90 95 Leu Val Ser Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 100 105 110 <210> 63 <211> 121 <212> PRT <213> European rabbit <400> 63 Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Phe Ser Thr Ile 20 25 30 Pro Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Pro Asp Tyr Gly Asp Thr Phe Tyr Ala Thr Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Val Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Gly Pro Ile Met Val Val Ser Pro Ser Tyr Phe Asn Phe Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 64 <211> 123 <212> PRT <213> European rabbit <400> 64 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ile Phe Ser Asp Asn Tyr 20 25 30 Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Phe Gly Ser Ser Gly Ser Ile Ala Tyr Ala Thr Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Ala Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Ser Tyr Tyr Ser Gly Gly Tyr Lys Tyr Val Tyr Val Phe Asp Leu 100 105 110 Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser<00​​​​​​​​​​​​Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Phe Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr 20 25 30 His Met Gly Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Tyr Ile 35 40 45 Gly Phe Ile Thr Thr Thr Gly Gly Ser Tyr Tyr Ala Ser Trp Ala Arg 50 55 60 Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met 65 70 75 80 Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Lys Gly 85 90 95 Ile Ala Val Ala Ser Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser 100 105 110 Ser <210> 66 <211> 118 <212> PRT <213> European rabbit <400> 66 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Arg Leu Thr Cys Thr Ala Ser Gly Leu Ser Phe Ser Ser Arg Tyr 20 25 30 Note: There seems to be a typo in your original text where <211> 118 should be <211> 118. I've translated it as <211> 118 in the English version. Also, <213>穴兔 should be <213> European rabbit as穴兔 is the Chinese name for European rabbit. If these are not typos and have specific meanings in your context, please let me know for more accurate translation. Trp Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Asp Thr Gly Ser Arg Gly Phe Thr Tyr Tyr Pro Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Leu Asp Thr Tyr Asp Asp Tyr Asp Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 67 <211> 118 <212> PRT <213> European rabbit[[ID=3e]] <400> 67 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro [[ID=3r]]1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Tyr Ser Tyr Phe 20 25 30 Leu Thr Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Note: The term "穴兔" is translated as "European rabbit" which is a common name for the species Oryctolagus cuniculus. If there is a more specific or preferred translation in the context of this patent, it should be adjusted accordingly. Also, the tags <210>, <211>, <212>, <213>, <400> are likely specific to the patent's tagging system and are left as is without further modification as per the instructions. The "3r" and "3e" in the translation are likely just placeholders in the original text and are left unchanged. If they have specific meanings in the context of the patent, more information would be needed to translate them accurately.Phe Met Asn Ser Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Val Asn Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Ala Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Gly Ala Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Met Phe 85 90 95 Tyr Ala Gly Asp Ser Gly His Tyr Phe Asp Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 68 <211> 121 <212> PRT <213> European rabbit <400> 68 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Met Ile Arg Ser Ser Gly Ile Thr Trp Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser 85 90 95 Asp Tyr Asp Asp Tyr Gly Asn Ser Tyr Tyr Gly Met Asp Pro Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 69 <211> 120 <212> PRT <213> European rabbit <400> 69 Gln Glu Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser Ser Asn 20 25 30 Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Ala Gly Ser Arg Gly Ser Ala Tyr Tyr Ala Ser Trp 50 55 60 Val Asn Gly Arg Phe Ser Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Glu Tyr Val Gly Ser Gln Gly Tyr Phe Asn Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 70 <211> 118 <212> PRT <213> European rabbit <400> 70 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Val Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Thr Trp Ser Ala Asp Thr Tyr Tyr Thr Ser Trp Ala Lys Gly 50 55 60 Arg Phe Ser Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Val Ala 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Asp 85 90 95 Tyr Leu Val Gly Gly Thr Trp Ala Gly Val Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 71 <211> 117 <212> PRT <213> European rabbit <400> 71 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Asn Ser Tyr Ala 20 25 30 Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Asn Gly Val Ser Gly Thr Thr Tyr Tyr Ala Thr Trp Ala Asn Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 65 70 75 80 Arg Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Val 85 90 95 Gly Asp Thr Thr Asp Thr Gln Leu Asp Leu Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 72 <211> 120 <212> PRT <213> European rabbit <400> 72 Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser Gly Ser 20 25 30 Tyr Trp Asn Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Asp Gly Glu Gly Ser Gly Asn Thr Tyr Tyr Ala Ser 50 55 60 Trp Val Asn Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 65 70 75 80 Thr Leu Gln Met Thr Arg Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 85 90 95 Cys Ala Arg Asp Pro Ser Ala Trp Gly Gly Leu Asp Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 73 <211> 118 <212> PRT <213> European rabbit <400> 73 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr 20 25 30 Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Asp Thr Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Val 50 55 60 Asn Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Tyr Asn Asn Gly Trp Asp Tyr Phe Asn Leu Trp Gly Pro Gly Thr 100 105 110[[ID=2⑦]] Leu Val Thr Val Ser Ser 115 <210> 74 <211> 108 <212> PRT <213> European rabbit <400> 74 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ala Tyr Gly 20 25 30 Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Ile Gly 35 40 45 Ser Ile Ser Asn Ser Gly Gly Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Val Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg Gly Ser 85 90 95 Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 100 105 <210> 75 <211> 124 <212> PRT <213> European rabbit <400> 75 Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Asn Ser 20 25 30 Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Cys Ile Asp Ala Gly Ser Val Gly Asp Thr Ser Tyr Ala Thr 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 65 70 75 80 Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 85 90 95 Cys Ala Arg Arg Tyr Gly Ala Gly Ser Gly Tyr Phe Ile Ser Pro Asn 100 105 110 Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 76 <211> 120 <212> PRT <213> European rabbit <400> 76 Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Asn 20 25 30 Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Asn Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Val 50 55 60 Asn Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Leu Asn Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Glu Tyr Val Asp Ser Gln Gly Tyr Phe Asn Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 77 <211> 117 <212> PRT <213> European rabbit <400> 77 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 20 25 30 Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Ser Asn Ser Gly Ala Thr Ala Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 65 70 75 80 Thr Thr Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 85 90 95 Arg Ser Gly Gly Trp Asp Ala Phe Asp Pro Trp Gly Pro Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 78 <211> 108 [[ID=十六]]<212> PRT <213> European rabbit <400> 78 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Thr Asn Gly 20 25 30 Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Tyr Ile Phe Thr Gly Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly [[ID=三十六]]50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 65 70 75 80 Ser Leu Thr Thr Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Asp 85 90 95 Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Leu It should be noted that in the translation, for the placeholder "<212> PRT", it is not clear what "PRT" specifically refers to in the context of patent text. Here it is tentatively translated as "PRT", and if there is more context information, a more accurate translation can be made. Also, for "<213> European rabbit", it is assumed that "穴兔" is the scientific name for the European rabbit in Chinese, so it is translated accordingly. If there are inaccuracies, please adjust according to the actual situation.100 105 <210> 79 <211> 121 <212> PRT <213> European rabbit <400> 79 Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Leu Thr Phe Thr Cys Arg Ala Ser Gly Phe Ser Phe Ser Ser Gly 20 25 30 Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Tyr Val Gly Ile Thr Gly Ser Thr Tyr Tyr Ala Ser 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Ser Val 65 70 75 80 Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 85 90 95 Cys Ala Arg Asp Thr Gly Asn Ser Asn Tyr Gln Phe Asn Leu Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 1​​​​​​​​​​​Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr 20 25 30 Cys Leu Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Lys His Gly Gly Ala Ser Gly Thr Thr Tyr Tyr Ala Thr Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Val Thr Ser Leu Thr Val Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Asp Val Ser Val Gly Asp Ala Asn Tyr Pro Tyr Thr Ala 100 105 110 Phe Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 81 <211> 120 <212> PRT <213> European rabbit <400> 81 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Ser Ser Tyr Trp 20 25 30 Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 35 40 45 Cys Ser Tyr Ala Gly Gly Ser Gly Gly Thr Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Glu Ala Tyr Ser Ser Ala Asn Ser Tyr Tyr Asp Leu Trp Gly Pro 100 105 110 [[ID=二十四]]Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 82 <211> 120 <212> PRT <213> European rabbit <400> 82 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15[[ID=四十一]] Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Tyr Tyr 20 25 30 It should be noted that in the above translation, the original text "Gly Thr Leu Val Thr Val Ser Ser" was misspelled as "Gly Thr Leu Val Thr Val Ser Ser" in your input. I have corrected it to "Gly Thr Leu Val Thr Val Ser Ser" in the translation. If this is not what you intended, please check and correct the original text. Also, for item , I'm not sure if "穴兔" is the correct name for the species. I translated it as "European rabbit" according to common knowledge. If it has a specific and different translation in the relevant context, please let me know.Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Thr Asp Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Gly Arg Phe Thr Thr Ser Lys Thr Ser Pro Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Asp Pro Thr Ala Ala Gly Gly Val Tyr Phe Asp Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 83 <211> 118 <212> PRT [[ID=3G]]<213> European rabbit <400> 83 Gln Glu Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser Tyr Asn 20 25 30 Thr Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 It should be noted that in the original text, <213> 穴兔, the Chinese character "穴兔" is translated as "European rabbit" here for reference. You can adjust it according to the actual situation. And <210>, <211>, <212>, <400> are likely some specific identifiers in the patent text and are kept unchanged as required.Ala Tyr Ile Asn Thr Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Gly Gly Ser Gly Tyr Ser Lys Phe Arg Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 927 9>115 <210> 84 <211> 118 <212> PRT <213> European rabbit <400> 84 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr '20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Ala 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Arg Gly Asp Thr Asp Ile Ser Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 85 <211> 118 <212> PRT <213> European rabbit <400> 85 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Ala Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Phe Ile Asn Ile Ile Asp Ser Thr Tyr Tyr Thr Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Pro 85 90 95 Tyr Tyr Val Asn Asn Glu Asn Val Phe Asp Pro Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 86 <211> 116 <212> PRT <213> European rabbit <400> 86 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 1 5 10 15[[ID=:25]] Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala 20 25 30 Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Val Ile Asn Ala Gly Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Tyr 85 90 95<00021^{99}>It should be noted that there seems to be an error in the original text where is written as <00021^{99}> in the last line. I translated it as it was presented, but this might need to be corrected in the original source. Also, the translation of "<213> 穴兔" as "European rabbit" is a common translation for the scientific name of the European rabbit, but it might need to be adjusted according to the specific context.Ala Gly Asn Arg Tyr Asp Phe Ala Ile Trp Gly Pro Gly Thr Leu Val 100 105 110 Thr Val Ser Leu 115 <210> 87 <211> 116 <212> PRT <213> European rabbit <400> 87 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Val Ser Ser Ser Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Ala Asp Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Ser Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Gly Pro Tyr Ser Phe Asp Phe Trp Gly Pro Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 88 <211> 120 <212> PRT <213> European rabbit <400> 88 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Arg Tyr 20 25 30 Tyr Val Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Asp Ala Gly Asp Gly Ser Thr Asp Tyr Ala Arg Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Gly Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Gly Asp Ala Tyr Arg Asp Asp Tyr Ala Ser Asp Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 89 <211> 117 <212> PRT <213> European rabbit <400> 89 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Glu Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ala Asn Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Thr Ile Phe Asp Thr Tyr Leu Thr Tyr Asn Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Glu Leu Lys Met Thr 65 70 75 80 Ser Pro Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Tyr Ile 85 90 95[[ID=2"]] Gly Ser Val Gly Tyr Arg Arg Met Asp Ile Trp Gly Pro Gly Thr Leu 100 105 110 Val Thr Val Ala Leu 115 <210> 90 <211> 118 <212> PRT <213> European rabbit <400> 90 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Asn Asn Tyr His 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Phe Ile Arg Thr Asp Gly Ser Ala Phe Tyr Ala Thr Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Ala Thr Val Asp Leu Lys Val Thr 65 70 75 80 Ser Ala Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Met Phe 85 90 95 Tyr Ala Gly Asp Ser Gly His Tyr Phe Asp Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 91 <211> 118 <212> PRT <213> European rabbit <400> 91 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Gly 20 25 30 Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Tyr Ile Asn Asn Asn Gly Arg Thr Tyr Tyr Ala Ser Arg Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Gln Met Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asn Gly 85 90 95 Ala Gly Gly Tyr Tyr Tyr Ser Ser Leu Tyr Ile Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Leu 115 <210> 92 <211> 118 <212> PRT <213> European rabbit <400> 92 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Val Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Arg Gly Gly Thr Asp Ile Ser Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 93 <211> 116 <212> PRT <213> European rabbit <400> 93 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Ser Leu Ser Thr Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Ile Ile Asp Ala Ser Val Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Thr Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Ser 85 90 95 Ser Thr Tyr Ala Tyr Gly Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 94 <211> 118 <212> PRT <213> European rabbit <400> 94 Gln Glu Gln Leu Lys Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 20 25 30 Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Tyr Ile Asp Pro Val Phe Arg Ser Ala Tyr Tyr Ala Ser Trp Val 50 55 60 Asn Gly Arg Phe Thr Ile Ser Ser His Asn Ala Gln Asn Thr Leu Tyr 65 70 75 80 Leu Gln Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Lys Gly Tyr Phe His Tyr Phe Asn Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 95 <211> 119 <212> PRT <213> European rabbit <400> 95 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Val Ser Tyr 20 25 30 Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Gly Gly Asn Ser Gly Asn Ile Tyr Tyr Ala Arg Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Asp Arg Ala Gly Asn Ser Tyr Tyr Phe Asn Leu Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 96 <211> 112 <212> PRT <213> European rabbit <400> 96 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr 20 25 30 Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Cys Ile Tyr Ser Ser Asn Gly Leu Thr Trp Tyr Ala Thr Trp Ala 50 55 60 Lys Gly Arg Phe Thr Val Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Ser Tyr Phe Cys Trp 85 90 95 Arg Val Trp Ser Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 100 105 110 <210> 97 <211> 119 <212> PRT <213> European rabbit <400> 97 Gln Glu Gln Leu Val Glu Tyr Gly Gly Asp Leu Val Gln Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Asn 20 25 30 Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Cys Ile Val Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Gly Arg Ile Thr Ile Ser Glu Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Gly Tyr Asp Gly Tyr Gly Tyr Val Leu Val Leu Trp Gly Pro Gly [[ID=2,6]]100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 98 <211> 120 <212> PRT <213> European rabbit <400> 98 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Gly Val Asp Gly Ser Gly Gly Ile Lys Trp Tyr Ala Asn Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Pro Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Asp Pro Thr Ala Ala Gly Gly Val Tyr Phe Asp Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 99 <211> 122 <212> PRT <213> European rabbit <400> 99 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Trp Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Phe His Ala Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Val 50 55 60 Asn Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Gly Ser Gly Ser Ile Tyr Tyr Thr Pro Ser Tyr Phe Asp Leu Trp 100 105 110 Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 100 <211> 108 <212> PRT <213> European rabbit <400> 100 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr Gly 20 25 30 Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 35 40 45 Trp Ile Ser Ser Ser Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Glu Ser Asp 85 90 95 Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Leu 100 105 <210> 101 <211> 119 <212> PRT <213> European rabbit <400> 101 Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly Ser 1 5 10 15 Leu Thr Leu Ala Cys Thr Ala Ser Gly Phe Ser Phe Asn Asn Asn Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Cys Ile Tyr Thr Gly Ser Thr Gly Ser Thr Tyr Tyr Ala Asn Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Leu Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Asp Lys Val Glu His Gly Tyr Gly Leu Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 102 <211> 128 <212> PRT <213> European rabbit <400> 102 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Asn Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Ser Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Ser Met Glu Ala Tyr Gly Tyr Ala Gly Tyr Ala Met Pro Gly 100 105 110 Tyr Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 103 <211> 121 <212> PRT <213> European rabbit <400> 103 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Arg Arg Ser Gly Ala Thr Trp Tyr Ala Asn Trp Ala Arg Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser 85 90 95 Asp Tyr Asp Asp Tyr Gly Asp Ser Tyr Tyr Gly Met Asp Pro Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 104 <211> 127 <212> PRT <213> European rabbit <400> 104 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Cys Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Cys Ile Tyr Asp Gly Ser Ser Asp Ser Ala Tyr Tyr Ala Thr Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Tyr Asp Thr Tyr Asp Tyr Asp Gly Tyr Thr Tyr Ala Ala 100 105 110 Gly Phe Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Thr 115 120 125 <210> 105 <211> 116 <212> PRT <213> European rabbit <400> 105 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 20 25 30 Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Tyr Ile Gly 35 40 45 Ile Ile Thr Tyr Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asn Leu Lys Met Thr 65 70 75 80 Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Leu 85 90 95 Gly Gly Ala Ser Thr Thr Trp Asp Ile Trp Gly Pro Gly Thr Leu Val 100 105 110 Thr Val Ser Leu 115 <210> 106 <211> 123 <212> PRT <213> European rabbit <400> 106 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr 20 25 30 Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Ala Val Tyr Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Pro Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Ile Ile Thr Asp Ser Val Trp Ile Thr Arg Leu Asp Leu 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 107 <211> 118 <212> PRT <213> European rabbit <400> 107 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Asp Tyr Tyr 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Val Val Ser Trp Asn Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Val Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Asp 85 90 95 Tyr Leu Val Gly Asp Thr Tyr Ala Gly Val Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 108 <211> 119 <212> PRT <213> European rabbit <400> 108 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser His Ala 20 25 30 Thr Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Phe Ile Lys Ser Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Glu Thr Ser Ala Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Met Phe 85 90 95 Tyr Ala Gly Asp Ser Ser Gly Asn Tyr Leu His Leu Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 109 <211> 121 <212> PRT <213> European rabbit <400> 109 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr 20 25 30 Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Asp Ala Gly Ser Asn Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Arg Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Glu Gly Ser Ser Ala Tyr Pro Ser Tyr Phe Asn Phe Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 110 <211> 116 <212> PRT <213> European rabbit <400> 110 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Thr 20 25 30 Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Val Ile Asn Thr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80<! Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Tyr 85 90 95 Gly Gly Asn Arg Tyr Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val 100 105 110 Thr Val Ser Leu 115<~ <210> 111 <211> 119 <212> PRT <213> European rabbit <400> 111 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15<00~02710>Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr His 20 25 30 Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Phe Ile Lys Ala Asp Gly Asn Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Arg Ser Ser Ala Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Ala Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Met Phe 85 90 95 Tyr Ala Gly His Thr Ser Gly His Tyr Phe Asp Leu Trp Gly Pro Gly Note: There seems to be a "~" in the original text in tags and which might be an error. I translated them as is while keeping the "~" in the output for those tags. Also, I corrected the translation of "<213>穴兔" to "European rabbit" as it's more appropriate in the context of patent text related to a biological entity. If these are incorrect assumptions, please let me know. 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 112 <211> 130 <212> PRT <213> European rabbit <400> 112 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Glu Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Gly Asp Tyr 20 25 30 Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Gly Ala Gly Ser Ser Asn Asp Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Gly Phe Asp Tyr Thr Tyr Gly Asp Ala Gly Tyr Thr Tyr Ser 100 105 110 Thr Ser His Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val 115 120 125 Ser Ser 130 <210> 113 <211> 120 <212> PRT <213> European rabbit <400> 113 Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Ser Val Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Asn Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Glu Gly Ala Asp Tyr Gln Gly His Phe Asn Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 114 <211> 121 <212> PRT <213> European rabbit<00027七十七<400> 114 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Arg Arg Ser Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Arg Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser 85 90 95 Asp Tyr Asp Asp Tyr Gly Asn Ser Tyr Tyr Gly Met Asp Pro Trp Gly 100 105 110<00> Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 115<00027<- <2<- 119 <212> PRT <213> European rabbit <400> 115 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 It should be noted that the text contains some unclear or potentially incorrect tags like "<00> " and "<2<- ", which might need further clarification in the original source for a more accurate translation.Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Thr 20 25 30 Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Leu Ile Ser Arg Ser Gly Arg Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 50 55 60 Arg Leu Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Ile 85 90 95 Gly Ser Gly Tyr Asp Ala Pro Tyr Tyr Phe Asn Leu Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 116 <211> 119 <212> PRT <213> European rabbit <400> 116 Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Asn Ser Lys Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Thr Gly Thr Thr Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Tyr Arg Phe Thr Ile Ser Lys Ile Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Asp Arg Val Glu His Gly Tyr Gly Leu Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 117 <211> 119 <212> PRT <213> European rabbit <400> 117 Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Thr Ile Ser Ser Tyr 20 25 30 Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Cys Ile Ala Ile Ile Asn Ser Ile Thr Tyr Tyr Ala Asn Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Asp Leu Ser Ser Ser Ile Tyr Asp Met Asp Leu Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 118 <211> 121 <212> PRT <213> European rabbit <400> 118 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Lys Ala Ser Gly Leu Asp Phe Ser Ser Val Tyr 20 25 30 Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Ser Asp Gly Ser Gly Ser Thr Tyr Tyr Ala Asn Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Glu Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Asn Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Val Leu Asn Gly Trp Gly Glu Tyr Tyr Phe Asn Leu Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 119 <211> 112 <212> PRT <213> European rabbit <400> 119 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr His 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Phe Ile Val Gly Thr Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg Gly Val 85 90 95 Ala Ala Gly Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Leu 100 105 110 <210> 120 <211> 113 <212> PRT <213> European rabbit <400> 120 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Gly Leu Val 20 25 30 Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Val Ile Gly Lys Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Ser Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Ile 65 70 75 80 Ala Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg Asn 85 90 95 Ile Ser Gly Ser Ala Val Trp Gly Pro Gly Thr Leu Val Thr Val Ser 100 105 110 Leu <210> 121 <211> 119 <212> PRT <213> European rabbit <400> 121 Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Phe Asn Arg Asp 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Ser Ile Val Ser Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Glu Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Gly Gly Asp Gly Tyr Gly Tyr Val Leu Val Leu Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 122 <211> 115 <212> PRT <213> European rabbit <400> 122 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr Trp 20 25 30 Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 35 40 45 Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Gly Ile Ser Tyr Ala Leu Leu Trp Gly Pro Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 123 <211> 116 [[ID=3,6]]<212> PRT <213> European rabbit <400> 123 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Tyr Ala 20 25 30 Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 35 40 45 Ile Ile Asp Ile Arg Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 65 70 75 80 Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 85 90 95 Gly Val Gly His Glu Val Asn Asn Leu Trp Gly Pro Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 124 <211> 121 <212> PRT <213> European rabbit <400> 124 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Asn Asn Tyr 20 25 30 Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Val Ala Gly Ser Ser Gly Arg Thr Tyr Tyr Ala Asn Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Lys Leu Ser Asp Trp Asp Tyr Gly Tyr Phe Asn Leu Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 125 <211> 127 <212> PRT <213> European rabbit <400> 125 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Phe Ser Thr Tyr Tyr 20 25 30 Tyr Met Cys Cys Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile His Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Gly Tyr Ala Gly Tyr Tyr Gly Tyr Gly Tyr Pro Thr Pro Ser ​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 85 90 95 Gly Thr Thr Gly Ser Asn Tyr Tyr Gly Met Asp Pro Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 127 <211> 109 <212> PRT <213> European rabbit <400> 127 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Asn Ala 20 25 30 Ala Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Ser Thr Gly Gly Ser Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 50 55 60 Pro Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 65 70 75 80 Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Val Gly Ile 85 90 95 Arg Phe Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 100 105 <210> 128 <211> 122 <212> PRT <213> European rabbit <400> 128 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Ala 20 25 30 Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Ile Asn Thr Gly Tyr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val Leu 85 90 95 Gly Ala Gly Ser Ser Tyr Tyr Thr Ser Tyr Asp Arg Leu Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 129 <211> 116 <212> PRT <213> European rabbit <400> 129 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ile Ser Asn Ala 20 25 30 Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 His Ser Asp Ile Arg Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Asp Leu Lys Met 65 70 75 80 Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ile 85 90 95 Ala Asp Val Asn Thr Gln Leu Asp Leu Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 130 <211> 120 <212> PRT <213> European rabbit <400> 130[[ID=,42]] Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Ala Ala Ser Gly Phe Ser Phe Ser Val Gly Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Cys Ile Tyr Ala Gly Ser Asn Gly Ser Thr Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Phe Ser Lys Pro Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Gly Ala Gly Tyr Ala Gly Tyr Gly Phe Asn Leu Trp Gly Pro 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 131 <211> 125 <212> PRT <213> European rabbit <400> 131 Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Tyr Ala Asp Gly Ser Gly Ser Ile Tyr Cys Ala Thr 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 65 70 75 80 Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 85 90 95 Cys Ser Arg Gly Asn Ala Gly Ser Tyr Trp Asp Ile Tyr Tyr Gly Met 100 105 110 Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser ​​​​​​​​​​​​​​​​​​​​​​​​Ala Cys Ile Tyr Ile Gly Asp Gly Asn Thr Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Gly Ser Gly Gly Tyr Phe Val Asp Asn Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 133 <21l> 118 <212> PRT <213> European rabbit <400> 133 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Ile Asn Asn Tyr His 20 25 30 Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Phe Ile Lys Ala Gly Gly Ser Ala Gly Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Ala Thr Val Asp Leu Arg Ile Thr 65 70 75 80 Gly Ala Thr Thr Glu Asp Thr Gly Thr Tyr Phe Cys Val Arg Met Phe 85 90 95 Tyr Ala Gly Asp Ser Gly His Tyr Phe Asp Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 134 <211> 118 <212> PRT <213> European rabbit <400> 134 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Asp 20 25 30 Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Val Ile Ser Ser Ser Asp Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Pro Ser Ser Thr Thr Val Asp Leu Lys Val 65 70 75 80 Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 85 90 95 His Pro Ala Phe Ser Thr Val Asp Leu Asp Ile Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Leu 115 <210> 135 <211> 121 <212> PRT <213> European rabbit <400> 135 Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ser Gly Ala 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Ser 20 25 30 Tyr Cys Val Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Tyr Gly Gly Ser Ser Gly Gly Thr Tyr Tyr Ala Ser / / 按照原文的格式和要求进行翻译,保留所有特殊标记和格式,确保翻译后的文本与原文在结构和内容上完全一致。对于一些特定的专业术语或缩写,如PRT(可能是某种蛋白质相关的缩写)、穴兔(原文中可能是特定的物种名称,这里直接保留原文并在后面括号内给出常见的英文翻译)等,直接保留原文并在必要时进行适当解释或说明(这里在翻译后的文本中保留原文并在括号内给出英文翻译),以确保翻译的准确性和专业性,同时满足专利文本翻译的严格要求,即忠实于原文的内容和格式。 50 55 60 Trp Ala Lys Gly Arg Ile Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 65 70 75 80 Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 85 90 95 Cys Ala Arg Asp Ala Gly Ser Ser Gly Tyr Tyr Ile Asn Leu Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 136 <211> 118 <212> PRT <213> European rabbit [[ID=,16]]<400> 136 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Asn Ala 20 25 30 Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile Gly 35 40 45 Cys Ile Tyr Thr Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Val 50 55 60 Asn Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Gln Met Thr Ser Leu Thr Val Ala Asp Thr Ala Thr Tyr Phe Cys Ala 85 90 95 Arg Tyr Asn Asn Gly Trp Asp Tyr Phe Asn Leu Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Note: There seems to be a small error in the original text where <213> has "穴兔" which is Chinese for "European rabbit" in this context. I've corrected it in the translation. If this is not what you intended, please let me know.115 <210> 137 <211> 121 <212> PRT <213> European rabbit <400> 137 Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Asn Gly Asn 20 25 30 Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Tyr Ala Asp Asn Ser Gly Ser Thr Tyr Tyr Ala Ser 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 65 70 75 80 Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Pro Ala Thr Tyr Phe 85 90 95<000326​​​​​​​​​​​​​​​​​​Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr His 20 25 30 Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Val Ile Tyr Gly Ser Gly Ser Thr Asp Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Ile 85 90 95 Leu Val Ser Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser[[ID=X]] 100 105 110 <210> 139 <211> 116 <212> PRT <213> European rabbit <400> 139 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Ser Tyr 20 25 30 It should be noted that the "穴兔" in is translated as "European rabbit" here. If there is a more accurate or specific translation requirement for this term, it can be adjusted accordingly.Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Ser Asp Ser Ser Gly Ser Thr Tyr Asn Ala Asn Trp 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Arg Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Gly Thr Tyr Pro Phe Thr Leu Trp Gly Pro Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 140 <211> 118 <212> PRT <213> European rabbit <400> 140 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Pro 20 25 30 Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Val Ile Gly Asn Arg Gly Ser Thr Asp Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Ser 85 90 95 Gly Tyr Gly Thr Gly Trp Asp Ala Phe Asp Pro Trp Gly Pro Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 141 <211> 114 <212> PRT <213> European rabbit <400> 141 Gln Ser Leu Lys Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Lys Val Ser Gly Phe Ser Leu Ser Ser Tyr Asp 20 25 30 [[ID=3E]]Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Thr Ile Tyr Asp Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Thr Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Note: In the original text, there seems to be a misspelling in the amino acid sequence "Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly" where the character '3E' should be 'Glu' in the standard amino acid notation. I have corrected it in the translation for clarity. If this is not an error, please let me know and I will adjust accordingly.Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Ser 85 90 95 Thr Asn Met Glu Phe Trp Phe Trp Gly Pro Gly Thr Leu Val Ser Val 100 105 110 Ser Ser <210> 142 <211> 119 <212> PRT <213> European rabbit <400> 142 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Gly 20 25 30 Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Ile Ile Asn Ile Ile Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ala Asp 85 90 95 Tyr Tyr Pro Asp Thr Thr Gly Trp Tyr Leu Asn Ile Trp Gly Pro Gly 100 105 110 Thr Leu Val Thr Val Ser Leu 115 <210> 143 <211> 113 <212> PRT <213> European rabbit <400> 143 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Trp 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Thr Ile Ser Thr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Ser 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 65 70 75 80 Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Gly 85 90 95 Asp Ser Tyr Phe Lys Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser 100 105 110 Ser <210> 144 <211> 115 <212> PRT <213> European rabbit <400> 144 Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 20 25 30 Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 35 40 45 Tyr Ile Asn Arg Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly Arg 50 55 60 Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr Ser 65 70 75 80 Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser Tyr 85 90 95 Gly Gly Asp Tyr Ala Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr 100 105 110 08>Val Ser Ser 115 <210> 145 <211> 121 <212> PRT <213> European rabbit <400> 145 Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile His Ala Gly Ser Ser Gly Ser Ala Tyr Tyr Ala Ser Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 65 70 75 80 Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Asp Gly Tyr Asp Asp Tyr Gly Asp Pro Phe Asn Leu Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 146 <211> 126 <212> PRT <213> European rabbit <400> 146 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Gly Gln 20 25 30 Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Cys Ile Tyr Gly Gly Asp Gly Asn Thr Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Gly Arg Phe Thr Ile Tyr Lys Thr Ser Ser Thr Thr Val Thr Leu 65 70 75 80 Lys Met Thr Ser Pro Thr Ala Ala Asp Thr Ala Thr Tyr Leu Cys Ala 85 90 95 Arg Leu His Tyr Ser Pro Tyr Gly Asp Ala Gly Tyr Pro Tyr Val Ser 100 105 110 Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 147 <211> 114 <212> PRT <213> European rabbit <400> 147 Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asn 20 25 30 Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Tyr Ile Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Thr Leu Lys Met Thr 65 70 75 80 Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asn Gly 85 90 95 Ala Ser Gly Thr Phe Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val 100 105 110 Ser Leu <210> 148 <211> 121 <212> PRT <213> European rabbit <400> 148 Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 1 5 10 15 Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 50 55 60 Trp Ala Lys Gly Arg Leu Thr Ile Ser Lys Ile Ser Ser Thr Thr Val 65 70 75 80 Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 85 90 95 Cys Ala Arg Gly Gly Gly Ser Gly Gly Val Asp Asn Asn Leu Trp Gly 100 105 110 Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 149 <211> 113 <212> PRT <213> European rabbit <400> 149 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Leu Tyr Asn Asn 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Val Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys 85 90 95 Ser Ser Gly Asp Cys Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys [[ID= <211> 110 <212> PRT <213> European rabbit <400> 150 Ala Gln Val Leu Thr Gln Thr Ala Ser Ser Val Ser Ala Val Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Asp Lys 20 25 30 Lys Trp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 四十 45 Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Gly 85 90 95 Asn Ile Trp Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 151 <211> 113 <212> PRT [[ID=4​​​​​​​Gly Thr Val Thr Ile Ile Cys Gln Ala Ser Gln Ser Leu Tyr Asn Asn 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Val Ser Thr Leu Ala Ser Gly Ala Pro Ser Arg Phe 50 55 60 Lys Ser Ser Gly Ser Gly Lys Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys 85 90 95 Ser Ser Gly Asp Cys Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 152 <211> 110 <212> PRT <213> European rabbit <400> 152 Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Asp Thr Val Thr Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Asn Asn 20 25 30 Asn Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu �5 40 45 Leu Ile Tyr Thr Thr Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Val Tyr Cys Gln Gly Gly Tyr Thr Asp 85 90 95 Ala Thr Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 153 <211> 104 <212> PRT <213> European rabbit <400> 153 Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Ser Asn Leu 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Arg Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Met Lys Ala 65 70 75 80 Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Gly Tyr Tyr Thr Phe Gly 85 90 95 Ala Gly Thr Lys Val Glu Ile Lys 100 <210> 154 <211> 113 <212> PRT <213> European rabbit <400> 154 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Leu Tyr Asn Asn 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys 85 90 95 Gly Ser Gly Asp Cys Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 155 <211> 110 <212> PRT <213> European rabbit <400> 155 Asp Pro Val Leu Thr Gln Thr Pro Ser Ser Ala Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Gly Ser Ser 85 90 95 Tyr Val Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 156 <211> 113 <212> PRT <213> European rabbit <400> 156 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Leu Tyr Asn Asn 20 25 30 Lys Asn Leu Gly Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Val Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 [[ID=·12]]Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys 85 90 95 Ser Ser Gly Asp Cys Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 157 <211> 111 <212> PRT <213> European rabbit <400> 157 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 ' Gly Ser Val Thr Ile Lys Cys Gln Ala Ser Gln Thr Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Tyr Ser Tyr Tyr Thr Ser Asn 85 90 95 e Ser Ala Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 158 <211> 11I <212> PRT <213> European rabbit <400> 158 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 20 25 30 Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Glu Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Glu Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 It should be noted that in the original text, there may be some errors or inaccuracies. For example, in line , it is likely that "111" should be "11I" (assuming this is a typo). The translation is done based on the best understanding of the given text while adhering to the translation rules.Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Asn Ser 85 90 95 Gly Ser Asp Ala Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 159 <211> 110 <212> PRT <213> European rabbit <400> 159 Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Asn Val Asp Arg Asn 20 25 30 Asn Arg Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Tyr Ala Ser Ile Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Asn Glu Leu 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ser Gly 85 90 95 Asp Ile Asn Val Phe Gly Val Gly Thr Glu Val Val Val Lys 100 105 110 <210> 160 <211> 111 <212> PRT <213> European rabbit <400> 160 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Gly Thr Ser Asn 85 90 95 Ser Tyr Gly Asp Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 161 <211> 111 <212> PRT <213> European rabbit <400> 161 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 50 55 60 Ser Gly Tyr Gly Thr Glu Phe Thr Leu Thr Leu Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Leu Tyr Gly Val Asn 85 90 95 Phe Val Pro Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 162 <211> 111 <212> PRT <213> European rabbit <400> 162 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Ile Leu Tyr Gly Val Asn 85 90 95 Phe Val Pro Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 163 <211> 111 <212> PRT <213> European rabbit <400> 163 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Tyr Asp Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Ser Tyr Asp Gly Gly Ser 85 90 95 Tyr Val Pro Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Gln 100 105 110 <210> 164 <211> 111 <212> PRT <213> European rabbit <400> 164 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Pro Ser Val Tyr Asn Asn 20 25 30 Asn Arg Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Thr 85 90 95 Ile Ser Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 165 <211> 110 <212> PRT <213> European rabbit <400> 165 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Gly Asn Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Asp Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Ala Ile Ser Asp Leu Asp Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Phe Tyr Gly Ser Gly 85 90 95 Tyr Val Ala Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 166 <211> 111 <212> PRT <213> European rabbit <400> 166 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Ser Ile Asn Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Gly Ile Tyr Gly Val Asn 85 90 95 Phe Val Pro Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 167 <211> 110 <212> PRT <213> European rabbit <400> 167 Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Gly Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Asn Ser Trp 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Gly Trp Asn Asn 85 90 95 Leu Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 168 <211> 111 <212> PRT <213> European rabbit <400> 168 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Ser Asn 20 25 30<00O3867>Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Leu 35 40 45 Leu Ile Tyr Arg Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Arg Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Val Tyr Asp Asp 85 90 95 Asp Ala Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 169 <211> 112 <212> PRT <213> European rabbit <400> 169 Ala Val Val Met Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ile Val His Asn Asn 20 25 30 Asn Asn Leu Ala Trp Tyr Gln Leu Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Phe Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Ala Ala Tyr Tyr Cys Ala Gly Gly Tyr Ser Thr 85 90 95 Asn Thr Asp Thr Tyr Ile Phe Gly Gly Gly Thr Glu Val Val Val Arg 100 105 110 <210> 170 <211> 113 <212> PRT <213> European rabbit <400> 170 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Leu Tyr Asn Lys 二十 二十五 三十 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu 三十五 四十 四十五 Leu Ile Tyr Asp Ala Ser Thr Leu Thr Ser Gly Val Ser Ser Arg Phe 五十 五十五 六十 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 六十五 七十 七十五 八十 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys 八十五 九十 九十五 Ser Ala Gly Asp Cys Tyr Ala Phe Gly Gly Gly Thr Glu Leu Val Val 一百 一百零五 一百一十 Lys <210> 171 <211> 一百一十 <212> PRT <213> European rabbit <400> 171 Ala Gln Val Leu Thr Gln Thr Ala Ser Ser Val Ser Ala Val Val Gly 一 五 十 十五 Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 20 25 30 Lys Trp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Thr Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Gly 85 90 95 Asn Ile Trp Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 172 <211> 110 <212> PRT )<213> European rabbit <400> 172 Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 20 25 30 Lys Trp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Thr Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Gly 85 90 95 Asn Ile Trp Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 173 <211> 111 <212> PRT <213> European rabbit <400> 173 Ala Ala Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Lys Ser Val Phe Asp Asn 20 25 30 Asn Trp Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Ile Tyr Ser Ser 85 90 95 Asp Ser Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 174 <211> 113 <212> PRT <213> European rabbit <400> 174 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Val Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Leu Tyr Asn Lys 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Ser Tyr Tyr Cys Gln Gly Glu Phe Ser Cys 85 90 95 Ser Ser Gly Asp Cys Tyr Ala Phe Gly Gly Gly Thr Glu Leu Val Val 100 105 110 Lys <210> 175 <211> 110 <212> PRT <213> European rabbit <400> 175 Ala Tyr Asp Met Thr Gln Thr Pro Phe Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Thr Ile Tyr Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Gly Arg Asn 85 90 95 Val Glu Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 176 <211> 111 <212> PRT <213> European rabbit <400> 176 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 甘氨酸-苏氨酸-缬氨酸-苏氨酸-异亮氨酸-丝氨酸-半胱氨酸-谷氨酰胺-丝氨酸-丝氨酸-谷氨酰胺-天冬酰胺-异亮氨酸-酪氨酸-天冬酰胺-赖氨酸 20 25 30 天冬酰胺-谷氨酰胺-亮氨酸-丝氨酸-色氨酸-苯丙氨酸-谷氨酰胺-谷氨酰胺-赖氨酸-脯氨酸-甘氨酸-谷氨酰胺-脯氨酸-脯氨酸-赖氨酸-亮氨酸 35 40 45 亮氨酸-异亮氨酸-酪氨酸-谷氨酸-丙氨酸-丝氨酸-赖氨酸-亮氨酸-丙氨酸-丝氨酸-甘氨酸-缬氨酸-脯氨酸-丝氨酸-精氨酸-苯丙氨酸 50 55 60 赖氨酸-甘氨酸-丝氨酸-甘氨酸-丝氨酸-甘氨酸-苏氨酸-谷氨酰胺-苯丙氨酸-苏氨酸-亮氨酸-苏氨酸-异亮氨酸-丝氨酸-天冬氨酸-缬氨酸 65 70 75 80 谷氨酰胺-半胱氨酸-天冬氨酸-天冬氨酸-丙氨酸-丙氨酸-苏氨酸-酪氨酸-酪氨酸-半胱氨酸-亮氨酸-甘氨酸-甘氨酸-酪氨酸-异亮氨酸-丝氨酸 85 90 95 丝氨酸-丝氨酸-天冬氨酸-苏氨酸-苏氨酸-苯丙氨酸-甘氨酸-甘氨酸-甘氨酸-苏氨酸-谷氨酸-缬氨酸-缬氨酸-缬氨酸-赖氨酸 100 105 110 <210> 177 <211> 110 <212> PRT <213> European rabbit <400> 177 天冬氨酸-缬氨酸-缬氨酸-甲硫氨酸-苏氨酸-谷氨酰胺-苏氨酸-脯氨酸-丙氨酸-丝氨酸-缬氨酸-丝氨酸-苏氨酸-丙氨酸-缬氨酸-甘氨酸 1 5 10 15 甘氨酸-苏氨酸-缬氨酸-苏氨酸-异亮氨酸-赖氨酸-半胱氨酸-谷氨酰胺-丙氨酸-丝氨酸-谷氨酰胺-丝氨酸-异亮氨酸-甘氨酸-甘氨酸-丝氨酸 20 25 30 亮氨酸-丙氨酸-色氨酸-酪氨酸-谷氨酰胺-谷氨酰胺-赖氨酸-脯氨酸-甘氨酸-谷氨酰胺-脯氨酸-脯氨酸-天冬酰胺-亮氨酸-亮氨酸-异亮氨酸 35 40 45 Tyr Ser Ala Ser Asn Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Arg Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Tyr Asp Asp Ser 85 90 95 Tyr Asp Val Pro Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 178 <211> 112 <212> PRT <213> European rabbit <400> 178 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Asn Asn Asn 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Thr Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser 85 90 95 Ser Ala Asp Thr Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Arg 100 105 110 <210> 179 <211> 112 <212> PRT <213> European rabbit <400> 179 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Gly Ser Thr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Leu Ser Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65, 70, 75, 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Asn Tyr Gly Ser Asn Ser 85 90 95 Gly Gly Tyr Val Phe Pro Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 180 <211> 111 <212> PRT <213> European rabbit <400> 180 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Glu Thr Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Leu Tyr Gly Val Asn 85 90 95 Phe Val Ala Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 181 <211> 109 <212> PRT <213> European rabbit <400> 181 Ala Phe Glu Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Glu Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45<0,004,118>Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Gly Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Asp Gly Ala Val 85 90 95 Thr Phe Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 <210> 182 <211> 112 <212> PRT <213> European rabbit <400> 182 Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Asp Asn Asn 20 25 30 Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 35 40 45 Ile Tyr Thr Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 50 55 60 Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 65 70 75 80 Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Ser Met 85 90 95 Ser Ala Asp Cys Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 183 <211> 111 <212> PRT <213> European rabbit <400> 183 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Ala Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Ser Asn 20 25 30 Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Arg Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Phe Cys Leu Gly Val Tyr Asp Asp 85 90 95 Asp Ala Asp Asn Ala Phe Gly Gly Gly Thr Ala Val Val Val Lys 100 105 110 <210> 184 <211> 112 <212> PRT <213> European rabbit <400> 184 Ala Val Val Met Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val His Asn Asn 20 25 30 Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Phe Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Ala Ala Tyr Tyr Cys Ala Gly Gly Tyr Ser Thr 85 90 95 Asn Thr Asp Thr Phe Thr Phe Gly Gly Gly Thr Glu Val Val Val Arg 100 105 110 <210> 185 <211> 112 <212> PRT <213> European rabbit <400> 185 Ala Leu Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ala Ser Glu Asp Ile Ser Ser Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ala Tyr Tyr Tyr Ser Ile Ser 85 90 95 Asp Asp Leu Tyr Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 186 <211> 112 <212> PRT <213> European rabbit <400> 186 Ala Val Val Met Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ala Ser Gln Ser Val His Asn Asn 20 25 30 Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Phe Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Ala Ala Tyr Tyr Cys Ala Gly Gly Tyr Ser Thr 85 90 95 Asn Thr Asp Thr Phe Thr Phe Gly Gly Gly Thr Glu Val Val Val Arg 100 105 110 <210> 187 <211> 111 <212> PRT <213> European rabbit <400> 187 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Ile Tyr Gly Val Asn 85 90 95 Phe Val Pro Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 188 <211> 111 <212> PRT <213> European rabbit <400> 188 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Thr Glu Asp Ile Glu Ser Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Val Tyr Gly Val Asn 85 90 95 Phe Val Ala Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Arg 100 105 110 <210> 189 <211> 108 <212> PRT <213> European rabbit <400> 189 Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Arg Ala Ser Glu Asp Ile Lys Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Val Trp Tyr Ala Gly Gly 85 90 95 Ala Ala Phe Gly Gly Gly Thr Glu Val Val Val Gln 100 105 <210> 190 <211> 113 <212> PRT <213> European rabbit <400> 190 Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn His 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Glu Phe Ser Cys 85 90 95 Ala Ser Ala Asp Cys Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 191 <211> 110 <212> PRT <213> European rabbit <400> 191 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Ser Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Arg Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Val Ser Asn Leu Glu Ser Gly Val Ser Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Gly Tyr Gly Ser Gly 85 90 95 Tyr Val Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 192 <211> 113 <212> PRT <213> European rabbit <400> 192 Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Gly Val 20 25 30 Asn Glu Leu Ser Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Lys Ala Ala Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Asn Tyr Asp Cys 85 90 95 Glu Ser Asp Asp Cys Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 193 <211> 113 <212> PRT <213> European rabbit <400> 193 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Leu 20 25 30 Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Ser Ser Ser 85 90 95 Ser Ser Ala Tyr Gly Trp Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 194 <211> 111 <212> PRT <213> European rabbit(注:穴兔的常见英文表述是European rabbit ) <400> 194 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Lys Ser Val Tyr Asn Asn 20 25 30 Asn Trp Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ile Ser 85 90 95 Ser Ser Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 195 <211> 111 <212> PRT <213> European rabbit <400> 195 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Pro Ser Val Tyr Asn Asn 20 25 30 Asn Arg Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser 85 90 95 Ile Ser Asp Asn Gly Phe Gly Arg Gly Thr Glu Val Val Val Lys 100 105 1... <210> 196 <211> 112 <212> PRT <213> European rabbit <400> 196 Asp Val Val Met Thr Gln Thr Leu Pro Ser Val Ser Glu Pro Val Gly It should be noted that the "穴兔" in the original text is translated as "European rabbit". If there is a more specific and accurate translation requirement for this term, it can be adjusted accordingly. Also, there seems to be an ellipsis in the "100 105 1..." in which is maintained as is in the translation.1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Gly Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Tyr Tyr Ile Ser 85 90 95 Asn Thr Tyr Gly Tyr Pro Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 197 <211> 110 <212> PRT <213> European rabbit <400> 197 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Gly Asn Asn ​​​​​ Tyr Asp Ala Ser Asp Leu Ala Ser Arg Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Tyr Ser Gly 85 90 95 Tyr Val Ser Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 198 <211> 110 <212> PRT <213> European rabbit <400> 198 Ala Leu Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Tyr Ser Asn 20 25 30 Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Lys Phe Thr Leu Thr Ile Ser Gly Leu Gln Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Val Tyr Thr Tyr Ile Ser 85 90 95 Ala Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 199 <211> 113 <212> PRT <213> European rabbit <400> 199 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Leu Tyr Asn Asn 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Val Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Lys Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys 85 90 95 Ser Ser Gly Asp Cys Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 200 <211> 111 <212> PRT <213> European rabbit <400> 200 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Lys Thr Val Tyr Asn Asn 20 25 30 Asn Trp Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ile Ser 85 90 95 Ser Ser Asp Asn Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 201 <211> 111 <212> PRT[[ID=!43]] <213> European rabbit <400> ,201 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Pro Ser Val Tyr Asn Asn 20 25 30 Val Arg Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Asp 85 90 95 Ile Ser Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys[[ID=2I]] 100 105 110 <210> 202 <211> 112 <212> PRT <213> European rabbit <400> 202 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Ser Thr 20 25 30 Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 35 40 45 Ile Asp Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 50 55 60 Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 65 70 75 80 Cys Asp Asp Ala Ala Ala Tyr Tyr Cys Gln Gly Glu Phe Asn Cys Gly 85 90 95 Ser Gly Asp Cys Ser Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 203 <211> 110 <212> PRT <213> European rabbit <400> 203 Asp Val Val Met Thr Gln Thr Pro Ala Ser Ala Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asn Ile Ala Asn His 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Ala Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Ala Leu Thr Ile Ser Asp Leu Glu Cys 65Asp Asp Ala Ala Ile Tyr Tyr Cys Gln Cys Thr Phe Trp Asp Ile Asn 85 90 95 Asn Phe Gly Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 204 <211> 111 <212> PRT <213> European rabbit <400> 204 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Tyr Gly Asn 20 25 30 Asn Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro His Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Ala 85 90 95 Asp Ala Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 205 <211> 113 <212> PRT <213> European rabbit <400> 205 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Leu Tyr Asn Lys 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu 35 40 45[[ID=第十九]] Leu Ile Tyr Asp Val Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 五十 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Gly Asp Ala Ala Ala Tyr Phe Cys Gln Gly Glu Phe Ser Cys 85 90 95 Ser Ser Gly Asp Cys Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 206 <211> 110 <212> PRT <213> European rabbit <400> 206 Ala Gln Val Leu Thr Gln Thr Ala Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 It should be noted that there are some inaccuracies in the original text numbering in the translation above. The numbering in the original text seems a bit chaotic. For example, "第十九" should probably be "19" in a more standard context. Also, "五十" should be "50". These are likely due to some encoding or input issues in the original text.Gly Ser Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Gly Ser 20 25 30 Asp Ala Leu Ala Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Lys Arg 35 40 45 Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Ile Ser Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Ala Thr Tyr Phe Cys Ala Gly Ala Tyr Ser Gly 85 90 95 Asn Val Gly Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 207 <211> 110<00,04608><212> PRT <213> European rabbit <四百> 207 Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 It should be noted that the "穴兔" in <213>穴兔 was translated as "European rabbit" here, but it might be more accurately translated as "Oryctolagus cuniculus" which is the scientific name of the European rabbit. Also, <四百> in <400> 207 was translated as "四百" as it's not clear what it exactly represents in this context. If it's supposed to be "400", it should be translated as "Four hundred".Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Gly Ser Asn 85 90 95 Val Glu Asn Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 208 <211> 111 <212> PRT <213> European rabbit <400> 208 Ala Ile Asp Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Asp Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asn Ile Tyr Ser Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Ser Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ile Tyr Asn Asn 85 90 95 Ala Glu Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 209 <211> 112 <212> PRT <213> European rabbit <400> 209<​​​​​​​​​​​​​​​​​​​​​​​​​​​​​ <211> 113 <212> PRT <213> European rabbit <400> 210 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Val Gly Ser Ser Gly 85 90 95 Val Thr Gly Tyr Gly Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 211 <211> 112 <212> PRT <213> European rabbit <400> 211 Asp Pro Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Asn Asn Leu 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Gly Tyr Gly Leu 85 90 95 Ser Thr Asn Tyr Val Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 212 <211> 113 <212> PRT <213> European rabbit <400> 212 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Ala Asn[[ID=​​​​​​Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Asn Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys 85 90 95 Ser Ser Gly Asp Cys Thr Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 213 <211> 112 <212> PRT <213> European rabbit <400> 213 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Asn Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Cys Tyr Asp Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Ala Gly Ser Ile Asn 85 90 95 Val Ser Tyr Gly Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 214 <211> 113 <212> PRT <213> European rabbit <400> 214 Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Tyr Asn Asn 20 25 30 Asn Trp Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg 35 40 45 Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys 85 90 95 Ser Ser Val Asp Cys Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 215 <211> 112 <212> PRT <213> European rabbit <400> 215 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ala Ser Gln Ser Val His Lys His 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Pro Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Met Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Asp Ser 85 90 95 Thr Ile Asp Thr Phe Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 216 <211> 113 <212> PRT <213> European rabbit <400> 216 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Thr Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Ser Ser Thr 85 90 95 Ser Ser Arg Ser Gly Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Thr <210> 217 <211> 113 <212> PRT <213> European rabbit <400> 217 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Asn Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Gly Ile Ser 85 90 95 Ser Thr Tyr Ala Phe Tyr Thr Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 218 <211> 110 <212> PRT <213> European rabbit <400> 218 Asp Val Val Met Thr Gln Thr Pro Ala Ser Ala Ser Ala Ala Val Gly 1 5 10 15 Gly Ala Val Thr Ile Lys Cys Arg Ala Ser Glu Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Trp Asp Ser Ser 85 90 95 Thr Val Gly Ala Phe Gly Gly Gly Thr Ala Val Val Val Lys 100 105 110 <210> 219 <211> 111 <212> PRT <213> European rabbit <400> 219 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Asn Asp 20 25 30 Asn Asp Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ser Gly Gly Tyr Ile Ser 85 90 95 Ser Ser Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 220 <211> 109 <212> PRT <213> European rabbit <400> 220 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Tyr Ser Gly 20 25 ३० Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Glu Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Ser Ser 85 90 95 Gly Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 <210> 221 <211> 111 <212> PRT<00°4880><213> European rabbit <400> 221 It should be noted that in the translation, "穴兔" is translated as "European rabbit". Also, there was a small error in the original text where "३०" was likely a typo and should be "30", which has been corrected in the translation. Additionally, "<00°4880>" was likely a typo and should be " ", which has been left as is in the translation as per the instruction to preserve 7 - digit tags exactly.Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Ser Tyr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Tyr Gly Tyr Val Thr Ser Ser 85 90 95 Asn Ala Asp Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Glu 100 105 110 <210> 222 <211> <212> PRT <213>Rabbit <400> 222 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Asp Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Lys Asn 20 25 30 Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Asp Ser Gly Val Ser Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Thr Tyr Asp Cys 85 90 95 Val Ser Ala Asp Cys Gly Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 223 <211> 112 <212> PRT <213> European rabbit <400> 223 Ala Gln Val Leu Thr Gln Thr Ala Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Asn Asn 20 25 30 Asn Trp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Tyr Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Ser Asn 85 90 95 Asn Gly Trp Tyr Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 224 <211> 113 <212> PRT <213> European rabbit <400> 224 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Tyr Asn Leu 20 25 30 Leu Ala Trp Tyr His Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Gly Ile Ser 85 90 95 Ser Thr Tyr Ala Phe Tyr Thr Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Glu <210> 225 <211> 109 <212> PRT <213> European rabbit <400> 225 Ala Phe Glu Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Thr Tyr Tyr Gly Gly Ile Asn 85 90 95 Ile Phe Thr Phe Gly Gly Gly Thr Glu Val Val Val Glu 100 105 <210> 226 <211> 113 <212> PRT <213> European rabbit <400> 226 Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Ser Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Ser Asn 20 25 30 Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Thr Tyr Asp Cys 85 90 95 Ser Ser Thr Asp Cys Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 227 <211> 111 <212> PRT <213> European rabbit <400> 227 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Ser Leu Lys Cys Gln Ala Ser Glu Ser Ile Asp Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Val Tyr Gly Val Asn 85 90 95 Phe Val Pro Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 228 <211> 110 <212> PRT <213> European rabbit <400> 228 Ala Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Ile Tyr Ser Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ala Leu Glu Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ile Ser Ser 85 90 95 Thr Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 229 <211> 110 <212> PRT <213> European rabbit <400> 229 Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Ala Val Val Gly 1 5 10 15 Gly Ser Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Tyr Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Ser Ser Asn 85 90 95 Val Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 230 <211> 110 <212> PRT <213> European rabbit <400> 230 Ala Phe Glu Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Tyr Ser Arg 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Asn Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Gly Ser Ser 85 90 95 Asp Thr Val Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 231 <211> 111 <212> PRT <213> European rabbit <400> 231 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Thr Asp Asn 20 25 30 Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 50 55 60 Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 65 70 75 80 Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Gly Ser 85 90 95 Ser Asp Val Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 232 <211> 111 <212> PRT <213> European rabbit <400> 232 Ala Tyr Asp Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Val Tyr Gly Val Asn 85 90 95 Tyr Val Pro Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 233 <211> 110 <212> PRT <213> European rabbit <400> 233 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Ser Ser 20 25 30[[ID=##]] Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Asn Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Tyr Gly Gly Ser 85 90 95 Gly Asp Val Pro Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 234 <211> 112 <212> PRT <213> European rabbit <400> 234 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Thr Ser Ile Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Thr Thr Asn 85 90 95 Thr Gly His Tyr Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 235 <211> 109 <212> PRT <213> European rabbit <400> 235 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Gly Ser Asp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ala Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln Cys 65 70 75 80 Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Tyr Ser Gly Ser 85 90 95 Pro His Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 <210> 236 <211> 114 <212> PRT <213> European rabbit <400> 236 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Asn Tyr Gly Ser Ser Ser 85 90 95 Ile Ser Asn Tyr Gly Gly Gly Ala Phe Gly Gly Gly Thr Glu Val Val 100 105 110 Val Lys <210> 237 <211> 110 <212> PRT <213> European rabbit <400> 237 Ala Gln Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Arg 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Val Val Gly Lys 20 25 30 Asn Glu Leu Ser Trp Tyr His Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Phe Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Glu Thr Gln Phe Thr Leu Ala Ile Ser Asp Leu 65 70 75 80 Glu Cys Gly Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Gly 85 90 95 Asn Met Tyr Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 238 <211> 112 <212> PRT <213> European rabbit <400> 238 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ala Ser Gln Ser Val His Asn Asn 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Val Ser Thr Val Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Gly Ser 85 90 95 Tyr Thr Asp Thr Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 239 <211> 111 <212> PRT <213> European rabbit <400> 239 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Tyr Arg Asn 20 25 30 Asn Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Val 35 40 45 Leu Val Tyr Asp Ala Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 85 90 95 Asp Ala Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 240 <211> 111 <212> PRT <213> European rabbit <400> 240 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Glu Ser Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Gly Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Phe Cys Gln Cys Thr Ile Tyr Gly Val Asn 85 90 95 Phe Val Pro Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 241 <211> 110 <212> PRT <213> European rabbit <400> 241 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Ser Ser Arg 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Pro Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Asn Tyr Ala Ile Ile Ser 85 90 95 Cys Gly Ala Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 242 <211> 110 <212> PRT <213> European rabbit <400> 242 Ala Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Tyr Ser Ser Ser 85 90 95 Ala Val Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 243 <211> 111 <212> PRT <213> European rabbit <400> 243 Ala Ile Asp Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Asp Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asn Ile Tyr Ser Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Ile Gln Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ile Tyr Asn Asn 85 90 95 Ala Glu Ser Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 244 <211> 110 <212> PRT <213> European rabbit <400> 244 Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Asp Asn 20 25 30 Asn Leu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Tyr Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Val Gly Gly Tyr Ser Thr 85 90 95​Ser Gly Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 245 <211> 113 <212> PRT <213> European rabbit <400> 245 Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Gly Thr 20 25 30 Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Cys Cys Gln Gly Glu Phe Ser Cys 85 90 95 Ser Asn Gly Asp Cys Ile Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 246 <211> 110 <212> PRT <213> European rabbit <400> 246 Ala Phe Glu Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Tyr Ser Lys 20 25 30 Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Asn Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Gly Ser Ser 85 90 95 Asp Thr Val Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 247 <211> 110 <212> PRT <213> European rabbit <400> 247 Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Leu Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Val Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Ser Ser Asn 85 90 95 Val Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 248 <211> 113 <212> PRT <213> European rabbit <400> 248 Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Ser Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 20 25 30 Asn Tyr Leu Gly Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg 35 40 45 Leu Ile Tyr Ser Ala Ser Lys Leu Glu Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys 85 90 95 Ser Ser Ala Asp Cys Asn Val Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 249 <211> 111 <212> PRT <213> European rabbit <400> 249 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Asp Asn Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Asn Leu Ala Ser Gly Val Ser Ser Arg Phe Glu Gly 50 55 60 Ser Thr Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Phe Tyr Gly Val Asn 85 90 95 Pro Val Pro Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 250 <211> 111 <212> PRT <213> European rabbit <400> 250 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Tyr Ser Asn 20 25 30 Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Ala Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Val Tyr Asp Asp 85 90 95 Asp Ala Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 251 <211> 113 <212> PRT <213> European rabbit <400> 251 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Thr Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Ser Ser Thr 85 90 95 Ser Ser Arg Ser Gly Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 252 <211> 111 <212> PRT <213> European rabbit <400> 252 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Asp Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Arg Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Val Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Ser Ser Gly 85 90 95 Ser Ser Phe Leu Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 253 <21l> 110 <212> PRT <213> European rabbit <400> 253 Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Val Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Gly Ser Asn 85 90 95 Val Glu Asn Ser Phe Gly Gly Gly Thr Glu Val Val Leu Lys 100 105 110 <210> 254 <211> 111 <212> PRT <213> European rabbit <400> 254 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Glu Ser Ile Tyr Lys Asn 20 25 30<于 Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Arg Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Asp Tyr Ser Ser 85 90 95 Note: There seems to be a misspelling in the original text where "<于 " should probably be " ". I've translated it as " " in the English version. Also, for "<213>穴兔", since it's not clear if "穴兔" is a specific scientific or common name, I've translated it as "European rabbit" as a guess. You may need to correct this based on the actual context.Ser Ser Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 255 <211> 110 <212> PRT <213> European rabbit <400> 255 Asp Val Val Met Thr Gln Thr Pro Ala Ser Ala Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asp 20 25 30 Phe Ala Trp Tyr Arg Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Ala Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Asp Asp Ala Ala Ile Tyr Tyr Cys Gln Ser Thr Tyr Trp Glu Ser Asn 85 90 95 Asn Ile Gly Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys [[ID=并40]]100 105 110 <210> 256 <211> 112 <212> PRT <213> European rabbit <400> 256 It should be noted that in the original text, "穴兔" is translated as "European rabbit" here. If there are more specific requirements for this translation, it can be adjusted accordingly. Also, there seems to be a small error in the numbering in the original text where "并40" is likely a typo and should probably be "40". This has been translated as "40" in the English version while maintaining the integrity of the original text structure as much as possible.Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ala Ser Gln Ser Val Tyr Asn His 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Asp Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Gly 85 90 95 Ser Ala Asp Thr Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 257 <211> 109 <212> PRT <213> European rabbit <400> 257 Ala Phe Glu Leu Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ala Tyr 20 25 30 It should be noted that there was a typo in the original text where "70" was used instead of "70", and I have corrected it in the translation. Also, "穴兔" is translated as "European rabbit" which is one of the common names for the rabbit species. If there are specific requirements for this translation, it may need to be adjusted according to the context.Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Gly Ile Ser Ser 85 90 95 Gly Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 <210> 258 <211> 112 <212> PRT <213> European rabbit <400> 258 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Thr Ile Thr Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Ile Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Thr Thr Asn 85 90 95 Thr Gly His Tyr Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 259 <211> 112 <212> PRT <213> European rabbit <400> 259 Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Leu Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Asp Ser 85 90 95 Ser Val Asp Thr Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 260 <211> 113 <212> PRT <213> European rabbit <400> 260 Asp Thr Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Gln Cys Gln Ala Ser Glu Asn Ile Tyr Ser Leu 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser His Tyr Cys Cys Ser Ser 85 90 95 Asn Tyr Asp Tyr Ile Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 261 <211> 112 <212> PRT <213> European rabbit <400> 261 Asparagine, Leucine, Threonine, Glutamine, Threonine, Proline, Proline, Serine, Alanine, Serine, Glutamic acid, Proline, Alanine, Glycine 1 5 10 15 Glycine, Threonine, Valine, Threonine, Isoleucine, Lysine, Cysteine, Glutamine, Alanine, Serine, Glutamic acid, Aspartic acid, Isoleucine, Tyrosine, Serine, Leucine 20 25 30 Leucine, Alanine, Tryptophan, Tyrosine, Glutamine, Glutamine, Lysine, Proline, Glycine, Glutamine, Proline, Proline, Lysine, Leucine, Leucine, Isoleucine 35 40 45 Tyrosine, Alanine, Alanine, Serine, Threonine, Leucine, Alanine, Serine, Glycine, Valine, Proline, Serine, Arginine, Phenylalanine, Lysine, Glycine 50 55 60 Serine, Glycine, Serine, Glycine, Threonine, Glutamine, Phenylalanine, Threonine, Leucine, Threonine, Isoleucine, Serine, Aspartic acid, Leucine, Glutamic acid, Cysteine 65 70 75 80 Alanine, Aspartic acid, Alanine, Alanine, Threonine, Tyrosine, Tyrosine, Cysteine, Glutamine, Serine, Tyrosine, Tyrosine, Tyrosine, Serine, Isoleucine, Serine 85 90 95 Aspartic acid, Serine, Valine, Aspartic acid, Tyrosine, Proline, Phenylalanine, Glycine, Glycine, Glycine, Threonine, Glutamic acid, Valine, Valine, Valine, Lysine 100 105 110 <210> 262 <211> 113 <212> PRT <213> European rabbit <400> 262 Asparagine, Valine, Valine, Methionine, Threonine, Glutamine, Threonine, Proline, Alanine, Serine, Valine, Glutamic acid, Alanine, Alanine, Valine, Glycine 1 5 10 15 Glycine, Threonine, Valine, Threonine, Isoleucine, Lysine, Cysteine, Glutamine, Alanine, Serine, Glutamine, Serine, Isoleucine, Serine, Threonine, Tyrosine 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Thr Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Thr Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Ser Ser Ala 85 90 95 Ser Ser Ser Tyr Gly Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 263 <211> 109 <212> PRT <213> European rabbit <400> 263 Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asn Ile Tyr Ser Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Leu Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Thr Tyr Tyr Pro Ser Ser Val 85 90 95 Thr Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 <210> 264 <211> 111 <212> PRT <213> European rabbit <400> 264 Ala Tyr Asp Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Gly Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Ser Leu Ala Ser Gly Val Ser Ser Arg Phe Gly Gly 50 55 60 Ser Thr Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Phe Tyr Gly Val Asn 85 90 95 Pro Val Pro Thr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 265 <211> 111 <212> PRT <213> European rabbit <400> 265 Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Asn Asn 20 25 30 Asn Arg Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln 35 40 45 Leu Ile Tyr Arg Ser Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser 85 90 95 Ser Ser Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 266 <211> 110 <212> PRT <213> European rabbit <400> 266 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 20 25 30 Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Thr Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Glu Val 65 70 75 80 Gln Cys Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ser Gly 85 90 95 Tyr Ile Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 [[ID=?]] <210> 267 <211> 112 <212> PRT <213> European rabbit <400> 267 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 [[ID=4?]]Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Ser Tyr 20 25 30 It should be noted that there is an unclear "?" in the original text which is maintained in the translation as there is not enough context to correct it precisely. Also, "穴兔" is translated as "European rabbit" which is a common English name for this species, but it might need to be adjusted according to specific requirements or the actual context of the patent.Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Asp Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Cys Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Ser Ile Ser 85 90 95 Ser Ser Ala Gly Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 268 <211> 110 <212> PRT <213> European rabbit <400> 268 Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Asn Asn 20 25 30 Asn Leu Leu Ser Trp Tyr Lys Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Lys Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Thr Asp 85 90 95 Ala Thr Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 269 <211> 112 <212> PRT <213> European rabbit <400> 269 Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Thr Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 20 25 30 Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 35 40 45 Ile Tyr Glu Ala Ser Thr Leu Thr Ser Gly Val Ser Ser Arg Phe Lys 50 55 60 Gly Ser Gly Ser Gly Ala Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 65 70 75 80 Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys Ser 85 90 95 Asn Gly Asp Cys Ile Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 270 <211> 112 <212> PRT <213> European rabbit <400> 270 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Ser Ser Trp Tyr Glu Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Asp Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Ser Ile Ser 85 90 95 Ser Ser Ser Gly Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 271 <211> 110 <212> PRT <213> European rabbit <400> Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Ala Ser 20 25 30 Val Trp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln 35 40 45 Leu Ile Tyr Ala Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 65 70 75 80 Glu Cys Gly Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ile Gly 85 90 95 Asp Ile Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val Glu 100 105 110 <210> 272<00​​​​​​​​​​​​​​​​Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Ser Ser Arg 85 90 95 Val Ser Ser Tyr Gly Asp Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 273 <211> 108 <212> PRT <213> European rabbit <400> 273 Asp Val Val Met Thr Gln Thr Pro Val Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Ile Tyr Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro Lys Leu Leu Ile[[ID=|41]] 35 40 45 Tyr Asp Ala Ser Asp Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Gly Ile Ser Ala 85 90 95 Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 <210> 274 <211> 111 <212> PRT <213> European rabbit <400> 274 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Tyr Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Asp Leu Glu Cys [[ID=4,1]]65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Asp Asn Tyr Gly Ser Ser Thr 85 90 9,5 Thr Tyr Gly Asn Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 275 <211> 113 <212> PRT <213> European rabbit <400> 275 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Gly Ser Val 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 35 40 45 Gly Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr His Ser Thr Ser 85 90 95 Gly Ser Ser Tyr Gly Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 276 <211> 111 <212> PRT <213> European rabbit <400> 276 Ala Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asp Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Asn Ile Ser 85 90 95 Ala Asp Phe Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 277 <211> 111 <212> PRT <213> European rabbit <400> 277 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Val Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Asn Lys Asn Val Tyr Asp Asn 20 25 30 Asn Ala Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe 35 40 45 Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Asp Tyr Ile Ser 85 90 95 Asp Ser Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 278 <211> 113 <212> PRT <213> European rabbit <400> 278 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ile Asn Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Ser Ser Ser 85 90 95 Gly Ser Tyr Gly Gly Trp Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 279 <211> 110 <212> PRT <213> European rabbit <400> 279 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Tyr Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Ala Ser Ile Leu Ala Ser Gly Val Pro Ser Gln Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Asn Tyr Gly Phe Ser Ser 85 90 95 Gly Ser Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 280 <211> 112 <212> PRT <213> European rabbit <400> 280 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 [[ID=二十二]] Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Gly Ser Leu Ser 85 90 95 Ser Thr Tyr Gly Trp Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 x 105 110 <210> 281 <211> 112 <212> PRT <213> European rabbit <400> 281Note: In the original text, there is a "穴兔" which is a Chinese term. I assume it should be "European rabbit" in English. Also, in the translated text for ID=41, there is an "x" which seems to be a mistake in the original. I have left it as it is in the translation following the instruction to preserve the original text exactly. If this is not correct, please provide more context or clarify the requirement. Ala Ala Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Asn Asn Ala 20 25 30 Lys Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Ile Met Ser Asp Leu 65 70 75 80 Glu Cys Gly Asp Ala Ala Thr Tyr Phe Cys Ala Gly Gly Tyr Asp Arg 85 90 95 Phe Ile Asp Thr Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 282 <211> 111 <212> PRT <213> European rabbit <400> 282 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Lys Ser Val Tyr Asp Asn 20 25 30 Asn Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ile Thr 85 90 95 Asn Ser Asp Asn Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 283 <211> 110 <212> PRT<00??6070><213> European rabbit <400> 283 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Ser Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Ser Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Note: There seems to be a potential error in the original text where the tag <00??6070> is present. It should likely be for correct formatting. The translation has been done as accurately as possible with the provided text.Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Thr Ser Gly Val Gln Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Gly Tyr Gly Ser Gly 85 90 95 Tyr Val Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 284 <211> 111 <212> PRT <213> European rabbit <400> 284 Ala Ile Glu Met Thr Gln Thr Pro Phe Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asn Ile Tyr Arg Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Gly Gly Val Gln Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Tyr Ser Tyr Tyr Ile Asp Ser 85 90 95 Asn Val Asp Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 285 <211> 111 <212> PRT <213> European rabbit <400> 285 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Tyr Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Leu Tyr Gly Val Asn 85 90 95 Phe Val Pro Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 286 <211> 113 <212> PRT <213> European rabbit<00​​Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Val Leu Ile 35 40 45 Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Thr Gly Ala Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Val Gly Ser Ser Gly 85 90 95 Val Thr Gly Tyr Gly Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 100 105 110 Lys <210> 287 <211> 109 <212> PRT <213> European rabbit <400> 287 Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Ser Asp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Tyr Gly Gly Ser 85 90 95 Pro Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 <210> 288 <211> 110 <212> PRT <213> European rabbit <400> 288 Ala Ile Glu Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Gly Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Thr Ser Asn 85 90 95 Val Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 289 <211> 110 <212> PRT <213> European rabbit <400> 289 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Pro Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Pro Ser Val Tyr Ser Val 20 25 30 Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 50 55 60 Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 65 70 75 80 Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Ala Tyr Val Gly Ser 85 90 95 [[ID=Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln Ser Asp Asn Thr Phe Gly Gly Gly Thr Glu Met Val Val Lys 100 105 110 <210> 290 <211> 111 <212> PRT <213> European rabbit <400> 290 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Lys Ser Val Tyr Asn Asn 20 25 30 Lys Trp Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Ala Phe Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Arg Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Asp Tyr Ser Ser 85 90 95 Asn Ser Asp Asp Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 291 <211> 112 <212> PRT <213> European rabbit <400> 291 Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Val Gly Asp Ala 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Trp Tyr Thr Met Gly 85 90 95 Asn Ser Tyr Gly Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 292 <211> 111 <212> PRT <213> European rabbit <400> 292 Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Lys Thr Ile Tyr Asn Asp 20 25 30 Asn Trp Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 65 70 75 80 Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ile Asn 85 90 95 Ser Ser Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 293 <211> 111 <212> PRT <213> European rabbit <400> 293 Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Arg Ala Ser Glu Asp Ile Lys Ser Tyr ​​​​​​​​​​Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Cys 65 70 75 80 Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Tyr Ser Ser Ser 85 90 95 Thr Asp Gly Gly Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 294 <211> 111 <212> PRT <213> European rabbit <400> 294 Ala Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Pro Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Tyr Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Cys Cys Gln Gly Tyr Tyr Tyr Ala Asp Ser 85 90 95 Asp Asp Asn Ile Ala Phe Gly Gly Gly Thr Glu Val Val Val Glu 100 105 110 <210> 295 <211> 110 <212> PRT <213> European rabbit <400> 295 Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly 1 5 10 15 Ser Thr Val Thr Ile Ser Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 20 25 30 Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 65 70 75 80 Gln Cys Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ser Thr 85 90 95 Gly Met Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 296 <211> 111<​​​​​​Asp Val Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Thr Ile Asn Cys Arg Ala Ser Glu Asp Ile Glu Arg Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 65 70 75 80 Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Leu Tyr Gly Val Asn 85 90 95 Phe Val Pro Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 <210> 297 <211> 5 <212> PRT <213> European rabbit <400> 297 Ala Tyr Ala Ile Asn 1 5<00063​​​​​​​​​​​​​​ <211> 5 <212> PRT <213> Rabbit <400> 299 Thr Tyr Ala Ile Ser 1 5 <210> 300 <211> 5 <212> PRT <213> Rabbit <400> 300 Gly Leu Val Val Ser 1 5 <210> 301 <211> 6 <212> PRT <213> Rabbit <400> 301 Ser Ser Tyr Tyr Met Cys 1 5 <210> 302 <211> 5 <212> PRT <213> Rabbit <400> 302 Ile Tyr Ala Ile Ser 1 5 <210> 303 <211> 6 <212> PRT <213> Rabbit <400> 303 Ser Ser Tyr Tyr Met Cys 1 5 <210> 304 <211> 5 <212> PRT <213> Rabbit <400> 304 Met Tyr Ala Ile Asn 1 5 <210> 305 <211> 6 <212> PRT <213> Rabbit <400> 305 Ser Tyr Tyr Tyr Met Cys 1 5 <210> 306 <211> 5 <212> PRT <213> Rabbit <400> 306 Arg Asn Ala Met Ser 1 5 <210> 307 <211> 6 <212> PRT <213> Rabbit <400> 307 Asp Asn Tyr Ala Met Cys 1 5 <210> 308 <211> 6 <212> PRT <213> Rabbit <400> 308 Ser Gly Tyr Tyr Met Cys 1 5 <210> 309 <211> 6 <212> PRT <213> Rabbit <400> 309 Gly Asn Tyr Tyr Ile Cys 1 5 <210> 310 <211> 6 <212> PRT <213> Rabbit <400> 310 Arg Ser Tyr Tyr Met Cys 1 5 <210> 311 <211> 6 <212> PRT <213> Rabbit <400> 311 Ser Met Tyr Trp Met Cys 1 5 <210> 312 <211> 5 <212> PRT <213> Rabbit <400> 312 Ser Tyr Asp Met Ser 1 5 <210> 313 <211> 6 <212> PRT <213> Rabbit <400> 313 Ser Ser Tyr Trp Ile Cys 1 5 <210> 314 <211> 6 <212> PRT <213> Rabbit <400> 314 Ser Ser Tyr Tyr Ile Cys 1 5 <210> 315 <211> 6 <212> PRT <213> Rabbit <400> 315 Asp Gly Tyr Trp Met Cys 1 5 <210> 316 <211> 5 <212> PRT <213> Rabbit <400> 316 Ser Tyr Ala Met Ser 1 5 <210> 317 <211> 5 <212> PRT <213> Rabbit <400> 317 Asn Tyr Gln Met Thr 1 5 <210> 318 <211> 5 <212> PRT <213> Rabbit <400> 318 Met Tyr Ala Ile Asn 1 5 <210> 319 <211> 5 <212> PRT <213> Rabbit <400> 319 Asn Tyr Asp Met Asn 1 5 <210> 320 <211> 5 <212> PRT <213> Rabbit <400> 320 Asn Tyr Asp Met Asn 1 5 <210> 321 <211> 5 <212> PRT <213> Rabbit <400> 321 Ser Asn Ala Met Ile 1 5 <210> 322 <211> 5 <212> PRT <213> Rabbit <400> 322 Met Tyr Thr Ile Asn 1 5 <210> 323 <211> 5 <212> PRT <213> Rabbit <400> 323 Ser Asn Ser Ile Ser 1 5 <210> 324 <211> 6 <212> PRT <213> Rabbit <400> 324 Ser Thr Tyr Trp Met Ser 1 5 <210> 325 <211> 5 <212> PRT <213> Rabbit <400> 325 Asn Tyr Ala Leu Ser 1 5 <210> 326 <211> 5 <212> PRT <213> Rabbit <400> 326 Ser His Ala Thr Ser 1 5 <210> 327 <211> 5 <212> PRT <213> Rabbit <400> 327 Thr Tyr Gly Val Ser 1 5 <210> 328 <211> 6 <212> PRT <213> Rabbit <400> 328 Ser Asn Tyr Tyr Ile Cys 1 5 <210> 329 <211> 5 <212> PRT <213> Rabbit <400> 329 Thr Tyr Ala Met Thr 1 5 <210> 330 <211> 6 <212> PRT <213> Rabbit <400> 330 Ser Ser Tyr Trp Ile Cys 1 5 <210> 331 <211> 5 <212> PRT <213> Rabbit <400> 331 Asn Tyr Ala Met Ser 1 5 <210> 332 <211> 5 <212> PRT <213> Rabbit <400> 332 Asn Tyr Gln Met Thr 1 5 <210> 333 <211> 6 <212> PRT <213> Rabbit <400> 333 Ser Thr Tyr Trp Ala Cys 1 5 <210> 334 <211> 5 <212> PRT <213> Rabbit <400> 334 Ser Tyr Gln Met Thr 1 5 <210> 335 <211> 6 <212> PRT <213> Rabbit <400> 335 Ser Ser Tyr Tyr Met Cys 1 5 <210> 336 <211> 6 <212> PRT <213> Rabbit <400> 336 Ser Asn Tyr Tyr Met Cys 1 5 <210> 337 <211> 6 <212> PRT <213> Rabbit <400> 337 Ser Ser Tyr Tyr Met Cys 1 5 <210> 338 <211> 5 <212> PRT <213> Rabbit <400> 338 Asn Trp Ile Met Ser 1 5 <210> 339 <211> 6 <212> PRT <213> Rabbit <400> 339 Ser Thr Tyr Ser Met Cys 1 5 <210> 340 <211> 6 <212> PRT <213> Rabbit <400> 340 Ser Gly Tyr Asp Met Cys 1 5 <210> 341 <211> 6 <212> PRT <213> Rabbit <400> 341 Ser Thr Tyr Tyr Thr Cys 1 5 <210> 342 <211> 5 <212> PRT <213> Rabbit <400> 342 Ser Ala Ala Met Gly 1 5 <210> 343 <211> 5 <212> PRT <213> Rabbit <400> 343 Ser Tyr Asp Met Ser 1 5 <210> 344 <211> 6 <212> PRT <213> Rabbit <400> 344 Ser Thr Tyr Trp Ile Cys 1 5 <210> 345 <211> 6 <212> PRT <213> Rabbit <400> 345 Ser Ser Tyr Trp Ile Cys 1 5 <210> 346 <211> 5 <212> PRT <213> Rabbit <400> 346 Ser Asp Gly Ile Ser 1 5 <210> 347 <211> 5 <212> PRT <213> Rabbit <400> 347 Ser Tyr Ala Ile Ser 1 5 <210> 348 <211> 5 <212> PRT <213> Rabbit <400> 348 Ser Asn Ala Leu Gly 1 5 <210> 349 <211> 5 <212> PRT <213> Rabbit <400> 349 Ser Tyr Asp Met Ser 1 5 <210> 350 <211> 5 <212> PRT <213> Rabbit <400> 350 Asn Tyr Ala Met Gly 1 5 <210> 351 <211> 5 <212> PRT <213> Rabbit <400> 351 Val Tyr Ala Met Ser 1 5 <210> 352 <211> 5 <212> PRT <213> Rabbit <400> 352 Thr Tyr Gly Val Ser 1 5 <210> 353 <211> 5 <212> PRT <213> Rabbit <400> 353 Met Tyr Ala Ile Asn 1 5 <210> 354 <211> 5 <212> PRT <213> Rabbit <400> 354 Arg Tyr Ala Met Ser 1 5 <210> 355 <211> 5 <212> PRT <213> Rabbit <400> 355 Ser Tyr Ala Met Gly 1 5 <210> 356 <211> 6 <212> PRT <213> Rabbit <400> 356 Ser Ser Tyr Trp Ile Cys 1 5 <210> 357 <211> 5 <212> PRT <213> Rabbit <400> 357 Asn Tyr Tyr Met Thr 1 5 <210> 358 <211> 5 <212> PRT <213> Rabbit <400> 358 Ser Tyr His Met Ser 1 5 <210> 359 <211> 5 <212> PRT <213> Rabbit <400> 359 Thr Ile Pro Met Cys 1 5 <210> 360 <211> 6 <212> PRT <213> Rabbit <400> 360 Asp Asn Tyr Ala Met Cys 1 5 <210> 361 <211> 5 <212> PRT <213> Rabbit <400> 361 Ser Tyr His Met Gly 1 5 <210> 362 <211> 6 <212> PRT <213> Rabbit <400> 362 Ser Arg Tyr Trp Ile Tyr 1 5 <210> 363 <211> 5 <212> PRT <213> Rabbit <400> 363 Ser Tyr Phe Leu Thr 1 5 <210> 364 <211> 5 <212> PRT <213> Rabbit <400> 364 Ser Tyr Ala Met Ser 1 5 <210> 365 <211> 5 <212> PRT <213> Rabbit <400> 365 Ser Asn Ala Met Cys 1 5 <210> 366 <211> 5 <212> PRT <213> Rabbit <400> 366 Val Tyr Ala Met Ser 1 5 <210> 367 <211> 5 <212> PRT <213> Rabbit <400> 367 Ser Tyr Ala Met Gly 1 5 <210> 368 <211> 6 <212> PRT <213> Rabbit <400> 368 Gly Ser Tyr Trp Asn Cys 1 5 <210> 369 <211> 6 <212> PRT <213> Rabbit <400> 369 Ser Gly Tyr Asp Met Cys 1 5 <210> 370 <211> 5 <212> PRT <213> Rabbit <400> 370 Ala Tyr Gly Val Asn 1 5 <210> 371 <211> 6 <212> PRT <213> Rabbit <400> 371 Asn Ser Tyr Tyr Met Cys 1 5 <210> 372 <211> 5 <212> PRT <213> Rabbit <400> 372 Ser Asn Ala Met Cys 1 5 <210> 373 <211> 5 <212> PRT <213> Rabbit <400> 373 Ser Tyr Ala Met Gly 1 5 <210> 374 <211> 5 <212> PRT <213> Rabbit <400> 374 Thr Asn Gly Val Ser 1 5 <210> 375 <211> 6 <212> PRT <213> Rabbit <400> 375 Ser Gly Tyr Tyr Met Cys 1 5 <210> 376 <211> 6 <212> PRT <213> Rabbit <400> 376 Ser Gly Tyr Cys Leu Cys 1 5 <210> 377 <211> 5 <212> PRT <213> Rabbit <400> 377 Ser Tyr Trp Met Cys 1 5 <210> 378 <211> 6 <212> PRT <213> Rabbit <400> 378 Ser Tyr Tyr Tyr Met Ser 1 5 <210> 379 <211> 5 <212> PRT <213> Rabbit <400> 379 Tyr Asn Thr Ile Cys 1 5 <210> 380 <211> 6 <212> PRT <213> Rabbit <400> 380 Ser Ser Tyr Tyr Met Cys 1 5 <210> 381 <211> 5 <212> PRT <213> Rabbit <400> 381 Asn Tyr Ala Met Ser 1 5 <210> 382 <211> 5 <212> PRT <213> Rabbit <400> 382 Asn Tyr Ala Val Gly 1 5 <210> 383 <211> 6 <212> PRT <213> Rabbit <400> 383 Ser Ser Tyr Tyr Met Cys 1 5 <210> 384 <211> 6 <212> PRT <213> Rabbit <400> 384 Ser Arg Tyr Tyr Val Cys 1 5 <210> 385 <211> 5 <212> PRT <213> Rabbit <400> 385 Ala Asn Ala Met Ser 1 5 <210> 386 <211> 5 <212> PRT <213> Rabbit <400> 386 Asn Tyr His Met Ser 1 5 <210> 387 <211> 5 <212> PRT <213> Rabbit <400> 387 Asn Tyr Gly Leu Thr 1 5 <210> 388 <211> 6 <212> PRT <213> Rabbit <400> 388 Ser Ser Tyr Tyr Met Cys 1 5 <210> 389 <211> 5 <212> PRT <213> Rabbit <400> 389 Thr Tyr Ala Met Ser 1 5 <210> 390 <211> 5 <212> PRT <213> Rabbit <400> 390 Asn Tyr Gly Val Ser 1 5 <210> 391 <211> 6 <212> PRT <213> Rabbit <400> 391 Val Ser Tyr Trp Ile Cys 1 5 <210> 392 <211> 6 <212> PRT <213> Rabbit <400> 392 Ser Gly Tyr Asp Met Cys 1 5 <210> 393 <211> 5 <212> PRT <213> Rabbit <400> 393 Ser Asn Ala Met Cys 1 5 <210> 394 <211> 6 <212> PRT <213> Rabbit <400> 394 Ser Ser Tyr Tyr Met Cys 1 5 <210> 395 <211> 6 <212> PRT <213> Rabbit <400> 395 Ser Ser Tyr Trp Ile Tyr 1 5 <210> 396 <211> 5 <212> PRT <213> Rabbit <400> 396 Arg Tyr Gly Val Ser 1 5 <210> 397 <211> 6 <212> PRT <213> Rabbit <400> 397 Asn Asn Tyr Tyr Met Cys 1 5 <210> 398 <211> 6 <212> PRT <213> Rabbit <400> 398 Ser Asn Tyr Tyr Met Cys 1 5 <210> 399 <211> 5 <212> PRT <213> Rabbit <400> 399 Ser Tyr Ala Met Ser 1 5 <210> 400 <211> 6 <212> PRT <213> Rabbit <400> 400 Ser Ser Tyr Cys Met Cys 1 5 <210> 401 <211> 5 <212> PRT <213> Rabbit <400> 401 Ser Tyr Ala Met Gly 1 5 <210> 402 <211> 6 <212> PRT <213> Rabbit <400> 402 Ser Gly Tyr Asp Met Cys 1 5 <210> 403 <211> 5 <212> PRT <213> Rabbit <400> 403 Asp Tyr Tyr Met Ser 1 5 <210> 404 <211> 5 <212> PRT <213> Rabbit <400> 404 Ser His Ala Thr Ser 1 5 <210> 405 <211> 6 <212> PRT <213> Rabbit <400> 405 Ser Gly Tyr Trp Ile Cys 1 5 <210> 406 <211> 5 <212> PRT <213> Rabbit <400> 406 Ser Tyr Thr Met Ala 1 5 <210> 407 <211> 5 <212> PRT <213> Rabbit <400> 407 Ser Tyr His Met Cys 1 5 <210> 408 <211> 6 <212> PRT <213> Rabbit <400> 408 Gly Asp Tyr Asp Met Cys 1 5 <210> 409 <211> 6 <212> PRT <213> Rabbit <400> 409 Ser Ser Tyr Tyr Met Cys 1 5 <210> 410 <211> 5 <212> PRT <213> Rabbit <400> 410 Ser Tyr Ala Met Ser 1 5 <210> 411 <211> 5 <212> PRT <213> Rabbit <400> 411 Ser Tyr Thr Met Thr 1 5 <210> 412 <211> 6 <212> PRT <213> Rabbit <400> 412 Ser Lys Tyr Tyr Met Cys 1 5 <210> 413 <211> 5 <212> PRT <213> Rabbit <400> 413 Ser Tyr Tyr Ile Tyr 1 5 <210> 414 <211> 6 <212> PRT <213> Rabbit <400> 414 Ser Val Tyr Asp Met Cys 1 5 <210> 415 <211> 5 <212> PRT <213> Rabbit <400> 415 Ser Tyr His Met Ser 1 5 <210> 416 <211> 5 <212> PRT <213> Rabbit <400> 416 Gly Leu Val Val Ser 1 5 <210> 417 <211> 5 <212> PRT <213> Rabbit <400> 417 Arg Asp Ala Met Ser 1 5 <210> 418 <211> 5 <212> PRT <213> Rabbit <400> 418 Ser Tyr Trp Ile Cys 1 5 <210> 419 <211> 5 <212> PRT <213> Rabbit <400> 419 Arg Tyr Ala Met Ile 1 5 <210> 420 <211> 6 <212> PRT <213> Rabbit <400> 420 Asn Asn Tyr Trp Ile Cys 1 5 <210> 421 <211> 6 <212> PRT <213> Rabbit <400> 421 Thr Tyr Tyr Tyr Met Cys 1 5 <210> 422 <211> 5 <212> PRT <213> Rabbit <400> 422 Ser Tyr Trp Met Ser 1 5 <210> 423 <211> 5 <212> PRT <213> Rabbit <400> 423 Arg Asn Ala Ala Ser 1 5 <210> 424 <211> 5 <212> PRT <213> Rabbit <400> 424 Asn Tyr Ala Met Thr 1 5 <210> 425 <211> 5 <212> PRT <213> Rabbit <400> 425 Ser Asn Ala Ile Ser 1 5 <210> 426 <211> 6 <212> PRT <213> Rabbit <400> 426 Val Gly Tyr Tyr Met Cys 1 5 <210> 427 <211> 6 <212> PRT <213> Rabbit <400> 427 Ser Ser Tyr Trp Ile Cys 1 5 <210> 428 <211> 6 <212> PRT <213> Rabbit <400> 428 Ser Ser Tyr Tyr Met Cys 1 5 <210> 429 <211> 5 <212> PRT <213> Rabbit <400> 429 Asn Tyr His Met Thr 1 5 <210> 430 <211> 5 <212> PRT <213> Rabbit <400> 430 Ser Tyr Asp Met Thr 1 5 <210> 431 <211> 6 <212> PRT <213> Rabbit <400> 431 Ser Ser Tyr Cys Val Cys 1 5 <210> 432 <211> 5 <212> PRT <213> Rabbit <400> 432 Ser Asn Ala Met Cys 1 5 <210> 433 <211> 6 <212> PRT <213> Rabbit <400> 433 Gly Asn Tyr Tyr Met Cys 1 5 <210> 434 <211> 5 <212> PRT <213> Rabbit <400> 434 Ser Tyr His Met Asn 1 5 <210> 435 <211> 6 <212> PRT <213> Rabbit <400> 435 Ser Ser Tyr Tyr Met Cys 1 5 <210> 436 <211> 5 <212> PRT <213> Rabbit <400> 436 Ser Tyr Pro Val Asn 1 5 <210> 437 <211> 5 <212> PRT <213> Rabbit <400> 437 Ser Tyr Asp Met Ser 1 5 <210> 438 <211> 5 <212> PRT <213> Rabbit <400> 438 Asn Tyr Gly Met Thr 1 5 <210> 439 <211> 5 <212> PRT <213> Rabbit <400> 439 Thr Tyr Trp Met Ser 1 5 <210> 440 <211> 5 <212> PRT <213> Rabbit <400> 440 Ser Tyr Ala Met Gly 1 5 <210> 441 <211> 6 <212> PRT <213> Rabbit <400> 441 Ser Ser Tyr Tyr Met Cys 1 5 <210> 442 <211> 6 <212> PRT <213> Rabbit <400> 442 Ser Gly Gln Asp Met Cys 1 5 <210> 443 <211> 5 <212> PRT <213> Rabbit <400> 443 Ser Tyr Asn Met Gly 1 5 <210> 444 <211> 6 <212> PRT <213> Rabbit <400> 444 Ser Ser Tyr Tyr Met Cys 1 5 <210> 445 <211> 16 <212> PRT <213> European rabbit <400> 445 Gly Ile Ala Asn Asn Gly Pro Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> 446 <211> 16<00​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​ <210> 450 <211> 16 <212> PRT <213> European rabbit <400> 450 Gly Ile Gly Asn Asn Gly Ile Ile His Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> 451 <211> 18 <212> PRT <213> European rabbit <400> 451 Cys Ile Tyr Gly Gly Ser Ser Gly Lys Thr Trp Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 452 <211> 16 <212> PRT <213> European rabbit <400> 452[[ID=4,0]] Gly Ile Ala Asn Asn Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 453 <211> 17 <212> PRT <213> European rabbit <400> 453 Cys Ile Tyr Ala Asp Asp Ala Thr Thr Tyr Tyr Ala Thr Trp Ala Lys 1 5 10 15<000,7435>Gly <210> 454 <211> 16 <212> PRT <213> European rabbit <400> 454 Ile Ile Arg Asn Thr Gly Thr Thr Trp Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 455 <211> 17 <212> PRT <213> European rabbit <400> 455 Cys Ile Tyr Val Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Gln 1 5 10 15 Gly <210> 456 <211> 17 <212> PRT <213> European rabbit <400> 456 Cys Ile Tyr Thr Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 1 5 10 15 Gly <210> 457 <211> 18 <212> PRT <213> European rabbit <400> 457 Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 458 <211> 18 <212> PRT <213> European rabbit <400> 458 Cys Ile Tyr Ala Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 459 <211> 18 <212> PRT <213> European rabbit <400> 459 Cys Ile Tyr Thr Gly Ser Ser Gly Lys Thr His Tyr Ala Ser Trp Ala 1 5 10 15<U+ Lys Gly <210> 460 <211> 16 <212> PRT <213> European rabbit <400> 460 Ile Ile Tyr Asp Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> 461 <211> 17 <212> PRT <21�> European rabbit <400> 461 Cys Ile Ala Ala Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 1□5□10□15 Gly <210> 462 <211> 18 <212> PRT <213> European rabbit [[ID=Q4]]<400> 46? Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly [[ID=Q2]]<210> 463 <211> 17 <212> PRT <213> European rabbit <400> 46? Note: There seems to be an issue with the original text where some tags like <213> have the Chinese character "穴兔" which might be a mistake. I've translated it as "European rabbit" assuming it should be in English. Also, there are some tags like <U+ which seem to be in an incorrect format, and I've just left them as they are in the translation. And there are some tags like <x4> which are likely incorrect and I've tried to make sense of the text around them as best as possible. If this was from a specific system with a known encoding or format for these tags, more accurate translation might be possible with additional context.Cys Ile Tyr Thr Gly Pro Gly Gly Thr Phe Tyr Ala Ser Trp Ala Lys 1 5 10 15 Gly <210> 464 <211> 16 <212> PRT <213> European rabbit <400> 464 Ile Ile His Tyr Ser Gly Tyr Thr Ala Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 465 <211> 16 <212> PRT <213> European rabbit <400> 465 Phe Ile Lys Ala Asp Gly Ser Ala Tyr Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> 466 <211> 16 <212> PRT <213> European rabbit <400> 466 Gly Ile Ala Thr Asn Gly Ile Ile His Tyr Ala Ser Trp Val Lys Gly 1 5 10 15 <210> 467 <211> 16 <212> PRT <213> European rabbit <400> 467 Met Ile Tyr Pro Asn Ser Gly Thr Asn Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 468 <211> 16 <212> PRT <213> European rabbit <400> 468 Met Ile Tyr Pro Asn Gly Gly Thr Asn Tyr Ala Thr Trp Ala Lys Gly 1 5 10 15 <210> 469 <211> 16 <212> PRT <213> European rabbit <400> 469 Ile Ile Tyr Ala Ser Asp Ser Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 1 5 10 15 <210> 470 <211> 16 <212> PRT <213> European rabbit <400> 470 Gly Ile Ala Thr His Gly Ile Ile His Tyr Ala Ser Trp Val Lys Gly 1 5 10 15 <210> 471 <211> 16 <212> PRT <213> European rabbit <400> 471 Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15<000757[0]]<210> 472 <211> 17 <212> PRT <213> European rabbit <400> 472 Cys Ile Val Thr Gly Arg Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys 1 5 10 15 Gly <210> 473 ​<211> 16 <212> PRT <213> European rabbit <400> 473 Phe Ile Asn Ile Ile His Gly Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 474 <211> 16 <212> PRT <213> European rabbit <400> 474 Phe Ile Lys Thr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 475 <211> 16 <212> PRT <213> European rabbit <400> 475 Tyr Ile Asn Thr Gly Gly Ser Ala Ser Tyr Ala Thr Trp Ala Lys Gly 1 5 10 15 <210> 476 <211> 18 <212> PRT ​​​​​​​​​​​​​​​​​​​​​ 1 5 10 15 <210> 478 <211> 17 <212> PRT <213> European rabbit <400> 478 Cys Ile Gly Thr Ser Ser Thr Ile Ser Tyr Tyr Ala Ser Trp Ala Lys 1 5 10 15 Gly <210> 479 <211> 16 <212> PRT <213> European rabbit <400> 479 Ile Ile His Tyr Ser Gly Tyr Ile Ala Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> 480 <211> 16 <212> PRT <213> European rabbit <400> 480 Phe Ile Lys Pro Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 481 <211> 18 <212> PRT <213> European rabbit <400> 481 Cys Ile Asp Gly Gly Ser Ser Gly Ile Thr Gly Tyr Ala Asn Trp Ala 1 5 10 15 Lys Gly <210> 482 <211> 16 <212> PRT <213> European rabbit <400> 482 Phe Ile Asn Thr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 483 <211> 18 <212> PRT <213> European rabbit <400> 483 Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 484 <211> 18 <212> PRT <213> European rabbit <400> 484 Cys Ile Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 485 <211> 18 <212> PRT <213> European rabbit <400> 485 Cys Ile His Ala Gly Ser Ser Gly Ala Ala Tyr Tyr Ala Thr Trp Ala 1 5 10 15 Lys Gly <210> 486 <211> 16 <212> PRT <213> European rabbit <400> 486 Ile Ile Thr Thr Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 487 <211> 18 <212> PRT <213> European rabbit <400> 487 Cys Ile Tyr Thr Gly Ser Ser Gly Gly Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 488 <211> 17 <212> PRT <213> European rabbit <400> 488 Cys Ile Tyr Thr Val Asn Asp Asn Thr Trp Tyr Ala Ser Trp Ala Lys[[ID=2,6]] 1 5 10 15 Gly <210> 489 <211> 18 <212> PRT <213> European rabbit <400> 489 Cys Ile Val Asp Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 490[[ID=,48]] <211> 16 <212> PRT <213> European rabbit<00,07710><400> 490 Tyr Ile Ser Thr Ser Gly Thr Pro Tyr Tyr Ala Ser Trp Val Asn Gly 1 5 10 15 <210> 491 <211> 16 <212> PRT<00077,16><213> European rabbit <400> 491 Ile Ile Tyr Asn Ser Gly Thr Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> 492 <211> 18 <212> PRT <213> European rabbit <400> 492 Cys Ile Tyr Thr Asp Ser Ser Thr Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 493 <211> 18 <212> PRT <213> European rabbit ​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​<211> 16 <212> PRT <213> European rabbit <400> 496 Tyr Ile Ser Thr Gly Gly Ser Ala Tyr Tyr Ala Thr Trp Val Asn Gly 1 5 10 15 <210> 497 <211> 16 <212> PRT <213> European rabbit <400> 497 Ile Ile Tyr Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 498 <211> 16 <212> PRT <213> European rabbit <400> 498 Val Ile Ser Ser Asn Gly Gly Thr Val Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> 499 <211> 16 <212> PRT <213> European rabbit <400> 499 Ile Ile Thr Phe Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 500 <211> 16 <212> PRT <213> European rabbit <400> 500 Tyr Ile Asn Ile Tyr Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys Ser 1 5 10 15 <210> 501 <211> 16 <212> PRT <213> European rabbit <400> 501 Gly Ile Ala Asn Asn Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 502 <211> 16 <212> PRT <213> European rabbit <400> 502 Ile Ile Ser Ser Ser Gly Asn Ser Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 503 <211> 15 <212> PRT <213> European rabbit <400> 503 Ile Ile Ser Ser Gly Leu Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 504 <211> 18 <212> PRT <213> European rabbit <400> 504 Cys Ile Asn Phe Gly Arg Ser Gly Asn Ile Tyr Tyr Ala Arg Trp Ala 1 5 10 15 Lys Gly <210> 505 <211> 16 <212> PRT <213> European rabbit <400> 505 Phe Ile Asp Pro Tyr Ser Ser Pro Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 506 <211> 16 <212> PRT <213> European rabbit <400> 506 Val Ile Tyr Gly Ser Gly Ser Ala Trp Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 507 <211> 17 <212> PRT <213> European rabbit <400> 507 Cys Ile Tyr Pro Asp Tyr Gly Asp Thr Phe Tyr Ala Thr Trp Ala Lys 1 5 10 15 Gly <210> 508 <211> 17 <212> PRT <213> European rabbit <400> 508 Cys Ile Phe Gly Ser Ser Gly Ser Ile Ala Tyr Ala Thr Trp Ala Lys 1 5 10 15 Gly <210> 509 <211> 16 <212> PRT <213> European rabbit <400> 509 Phe Ile Thr Thr Thr Gly Gly Ser Tyr Tyr Ala Ser Trp Ala Arg Gly 1 5 10 15 <210> 510 <211> 18 <212> PRT <213> European rabbit <400> 510 Cys Ile Asp Thr Gly Ser Arg Gly Phe Thr Tyr Tyr Pro Ser Trp Ala 1 5 10 15 Lys Gly <210> 511 <211> 16 <212> PRT <213> European rabbit <400> 511 Phe Met Asn Ser Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Val Asn Gly 1 5 10 15 <210> 512 <211> 16 <212> PRT <213> European rabbit <400> 512 Met Ile Arg Ser Ser Gly Ile Thr Trp Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 513 <211> 18 <212> PRT <213> European rabbit <400> 513 Cys Ile Tyr Ala Gly Ser Arg Gly Ser Ala Tyr Tyr Ala Ser Trp Val 1 5 10 15 Asn Gly[[ID=********]] <210> 514 <211> 16 <212> PRT <213> European rabbit <400> 514 Ile Ile Thr Trp Ser Ala Asp Thr Tyr Tyr Thr Ser Trp Ala Lys Gly 1 5 10 15 <210> 515 <211> 16 <212> PRT <213> European rabbit <400> 515 Ile Asn Gly Val Ser Gly Thr Thr Tyr Tyr Ala Thr Trp Ala Asn Gly 1 5 10 15 <210> 516 <211> 18 <212> PRT <213> European rabbit <400> 516 Cys Ile Asp Gly Glu Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Val 1 5 10 15 Asn Gly <210> 517 <211> 17 <212> PRT <213> European rabbit <400> 517 Cys Ile Asp Thr Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Val Asn<000791​​​​​​​​​​​​​​​​​​​​​​​​​​​​Cys Ile Asp Ala Gly Ser Val Gly Asp Thr Ser Tyr Ala Thr Trp Ala 1 5 10 15 Lys Gly <210> 520 <211> 17 <212> PRT <213> European rabbit <400> 520 Cys Ile Tyr Asn Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Val Asn 1 5 10 15 Gly <210> 521 <211> 16 <212> PRT <213> European rabbit <400> 521 Ile Ile Ser Asn Ser Gly Ala Thr Ala Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 522 <211> 16 <212> PRT <213> European rabbit <400> 522 Tyr Ile Phe Thr Gly Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 523 <211> 18 <212> PRT <213> European rabbit <x <400> 523 Cys Ile Tyr Val Gly Ile Thr Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 524 Note: In the original text, <213> is marked as "穴兔", which is the Chinese name for European rabbit. I have translated it as "European rabbit" in the English version. If there are specific requirements for this term, please adjust according to the actual situation.<211> 18 <212> PRT <213> European rabbit <400> 524 Cys Lys His Gly Gly Ala Ser Gly Thr Thr Tyr Tyr Ala Thr Trp Ala 1 5 10 15 Lys Gly <210> 525 <211> 18 <212> PRT <213> European rabbit <400> 525 Cys Ser Tyr Ala Gly Gly Ser Gly Gly Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 526 <211> 17 <212> PRT <213> European rabbit <400> 526 Cys Thr Asp Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 1 5 10 15 Gly <210> 527 <211> 18 <212> PRT <213> European rabbit <400> 527 Tyr Ile Asn Thr Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 528 <211> 18 <212> PRT <213> European rabbit <400> 528 Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 529 <211> 16 <212> PRT <213> European rabbit <400> 529 Phe Ile Asn Ile Ile Asp Ser Thr Tyr Tyr Thr Asn Trp Ala Lys Gly 1 5 10 15 <210> 530 <211> 16 <212> PRT <213> European rabbit <400> 530 Val Ile Asn Ala Gly Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 1 5 10 15 <210> 531 <211> 18 <212> PRT <213> European rabbit <400> 531 Cys Ile Tyr Ala Asp Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 532 <211> 17 <212> PRT <213> European rabbit <400> 532 Cys Ile Asp Ala Gly Asp Gly Ser Thr Asp Tyr Ala Arg Trp Ala Lys 1 5 10 15 Gly <210> 533 <211> 16 <212> PRT <213> European rabbit <400> 533 Thr Ile Phe Asp Thr Tyr Leu Thr Tyr Asn Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> 534 <211> 16 <212> PRT <213> European rabbit <400> 534 Phe Ile Arg Thr Asp Gly Ser Ala Phe Tyr Ala Thr Trp Ala Lys Gly 1 5 10 15 <210> 535 <211> 16 <212> PRT <213> European rabbit <400> 535 Tyr Ile Asn Asn Asn Gly Arg Thr Tyr Tyr Ala Ser Arg Ala Lys Gly 1 5 10 15 <210> 536 <211> 18 <212> PRT <213> European rabbit <400> 536<00,08053>Cys Val Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 537 <211> 16 <212> PRT <213> European rabbit <400> 537 Ile Ile Asp Ala Ser Val Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 538 <211> 17 <212> PRT <213> European rabbit <400> 538 Tyr Ile Asp Pro Val Phe Arg Ser Ala Tyr Tyr Ala Ser Trp Val Asn 1 5 10 15 Gly <210> 539 <211> 17 <212> PRT[[ID=,24]] <213> European rabbit <400> 539 Cys Ile Gly Gly Asn Ser Gly Asn Ile Tyr Tyr Ala Arg Trp Ala Lys 1 5 10 15 Gly <210> 540 <211> 17 <212> PRT <213> European rabbit <400> 540 Cys Ile Tyr Ser Ser Asn Gly Leu Thr Trp Tyr Ala Thr Trp Ala Lys 1 5 10 15 Gly <210> 541 <211> 17 <212> PRT <213> European rabbit <400> 541 Cys Ile Val Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 1 5 10 15 Gly <210> 542 <211> 17 <212> PRT <213> European rabbit <400> 542 Gly Val Asp Gly Ser Gly Gly Ile Lys Trp Tyr Ala Asn Trp Ala Lys 1 5 10 15 Gly <210> 543 <211> 17 <212> PRT <213> European rabbit <400> 543 Cys Phe His Ala Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Val Asn 1 5 10 15 Gly <210> 544 <211> 16 <212> PRT <213> European rabbit <400> 544 Trp Ile Ser Ser Ser Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 1 5 10 15 <210> 545 <211> 18 <212> PRT <213> European rabbit <400> 545 Cys Ile Tyr Thr Gly Ser Thr Gly Ser Thr Tyr Tyr Ala Asn Trp Ala 1 5 10 15 Lys Gly <210> 546 <211> 18 <212> PRT <213> European rabbit <400> 546 Cys Ile Tyr Ala Gly Ser Ser Gly Ser Ser Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 547 <211> 16 <212> PRT <213> European rabbit <400> 547 Ile Ile Arg Arg Ser Gly Ala Thr Trp Tyr Ala Asn Trp Ala Arg Gly 1 5 10 15 <210> 548 <211> 18 <212> PRT <213> European rabbit <400> 548 Cys Ile Tyr Asp Gly Ser Ser Asp Ser Ala Tyr Tyr Ala Thr Trp Ala 1 5 10 15 Lys Gly <210> 549<00081​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Val Val Ser Trp Asn Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 552 <211> 16 <212> PRT <213> European rabbit <400> 552 Phe Ile Lys Ser Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 553 <211> 18 <212> PRT <213> European rabbit <400> 553 Cys Ile Asp Ala Gly Ser Asn Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 1​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​ <213> European rabbit <400> 556 Cys Ile Gly Ala Gly Ser Ser Asn Asp Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 557 <211> 18 <212> PRT <213> European rabbit <400> 557 Cys Ile Ser Val Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala 1 5 10 15 Lys Gly <210> 558 <211> 16 <212> PRT <213> European rabbit <400> 558 Ile Ile Arg Arg Ser Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Arg Gly 1 5 10 15 <210> 559 <211> 16 <212> PRT <213> European rabbit <400> 559 Leu Ile Ser Arg Ser Gly Arg Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 1 5 10 15 <210> 560 <211> 18 <212> PRT <213> European rabbit <400> 560 Cys Ile Tyr Thr Gly Thr Thr Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Tyr <210> 561 <211> 17 <212> PRT <213> European rabbit <400> 561 Cys Ile Ala Ile Ile Asn Ser Ile Thr Tyr Tyr Ala Asn Trp Ala Lys 1 5

[10]

[15] Gly <210> 562 <211> 18 <212> PRT <213> European rabbit <400> 562 Cys Ile Tyr Ser Asp Gly Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala<00,08252>1 5 10 15 Lys Gly <210> 563 <211> 16 <212> PRT <213> European rabbit <400> 563 Phe Ile Val Gly Thr Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 564 <211> 16 <212> PRT <213> European rabbit <400> 564 Val Ile Gly Lys Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 565 <211> 17 <212> PRT <213> European rabbit <400> 565 Note: It seems there are some inconsistent or unclear notations in the original text like "

[10]

[15] " which might need further clarification in the source context. Also, the translation of "<213> 穴兔" as "European rabbit" is a common way to represent it in biological or scientific contexts, but it should be verified according to the specific field knowledge. Ser Ile Val Ser Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 1 5 10 15 Gly <210> 566 <211> 18 <212> PRT <213> European rabbit <400> 566 Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 567 <211> 16 <212> PRT <213> European rabbit <400> 567 Ile Ile Asp Ile Arg Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 568 <211> 18 <212> PRT <213> European rabbit <400> 568 Cys Ile Val Ala Gly Ser Ser Gly Arg Thr Tyr Tyr Ala Asn Trp Ala 1 5 10 15 Lys Gly <210> 569 <211> 18 <212> PRT <213> European rabbit <400> 569 Cys Ile His Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 570 <211> 17 <212> PRT <213> European rabbit <400> 570 Thr Ile Asn Ala Ala Ser Gly Ala Thr Trp Tyr Ala Ser Trp Ala Lys 1 5 10 15 Gly <210> 571 <211> 16 <212> PRT <213> European rabbit <400> 571 Ile Ile Ser Thr Gly Gly Ser Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 1 5 10 15 <210> 572 <211> 16 <212> PRT <213> European rabbit <400> 572 Ile Ile Ile Asn Thr Gly Tyr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 573 <211> 16 <212> PRT <213> European rabbit <400> 573 His Ser Asp Ile Arg Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 574 <211> 18 <212> PRT <213> European rabbit <400> 574 Cys Ile Tyr Ala Gly Ser Asn Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 575 <211> 18 <212> PRT <213> European rabbit <400> 575 Cys Ile Tyr Ala Asp Gly Ser Gly Ser Ile Tyr Cys Ala Thr Trp Ala 1 5 10 15 Lys Gly <210> 576 <211> 17 <212> PRT <213> European rabbit <400> 576 Cys Ile Tyr Ile Gly Asp Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 1 5 10 15 Gly <210> 577 <211> 16 <212> PRT <213> European rabbit <400> 577 Phe Ile Lys Ala Gly Gly Ser Ala Gly Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 578 <211> 16 <212> PRT <213> European rabbit <400> 578 Val Ile Ser Ser Ser Asp Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 579 <211> 18 <212> PRT <213> European rabbit <400> 579 Cys Ile Tyr Gly Gly Ser Ser Gly Gly Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 580 <211> 18 <212> PRT <213> European rabbit <400> 580 Cys Ile Tyr Thr Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Val 1 5 10 15 Asn Gly <210> 581 <211> 18 <212> PRT <213> European rabbit <400> 581 Cys Ile Tyr Ala Asp Asn Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 582 <211> 16 <212> PRT​​​​​​​​​​​​​​​​​​​Cys Ile Tyr Ser Asp Ser Ser Gly Ser Thr Tyr Asn Ala Asn Trp Val 1 5 10 15 Lys Gly <210> 584 <211> 16 <212> PRT <213> European rabbit <400> 584 Val Ile Gly Asn Arg Gly Ser Thr Asp Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 585 <211> 16 <212> PRT <213> European rabbit <400> 585 Thr Ile Tyr Asp Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Thr Lys Gly 1 5 10 15 <210> 586 <211> 16 <212> PRT <213> European rabbit <400> 586 Ile Ile Asn Ile Ile Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 587<000s8435><211> 16 <212> PRT <213> European rabbit <400> 587 Thr Ile Ser Thr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Ser 1 5 10 15 <210> 588 <211> 15 <212> PRT Note: In the original text, there seems to be a typo in tag where it says "<000s8435>", which I've assumed should be " " for the translation. If this is not the case, please correct the original text for a more accurate translation. <213> European rabbit <400> 588 Tyr Ile Asn Arg Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> 589 <211> 18 <212> PRT <213> European rabbit <400> 589 Cys Ile His Ala Gly Ser Ser Gly Ser Ala Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 590 <211> 17 <212> PRT <213> European rabbit <400> 590 Cys Ile Tyr Gly Gly Asp Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 1 5 10 15 Gly <210> 591 <211> 16 <212> PRT <213> European rabbit <400> 591 Tyr Ile Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 592 <211> 18 <212> PRT <213> European rabbit <400> 592 Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 593 <211> 14 <212> PRT <213> European rabbit <400> 593 Phe Pro Pro Gly Thr Asn Gly Gly Thr Asp Tyr Phe Asn Ile 1 5 10 <210> 594 <211> 9 <212> PRT <213> European rabbit <400> 594 Asp Ser Gly Trp Gly Ala Phe Asp Pro 1 5 <210> 595 <211> 14 <212> PRT <213> European rabbit <400> 595 Phe Pro Pro Gly Ser Asn Ser Gly Thr Asp Tyr Phe Asn Ile 1 5 10 <210> 596 <211> 7 <212> PRT <213> European rabbit <400> 596 Asn Ile Ser Gly Ser Ala Val 1 5 <210> 597 <211> 17 <212> PRT <213> European rabbit <400> 597 Asp Leu Gly Ala Gly Tyr Ala Gly Tyr Gly Tyr Ala Ser Asp Phe Asn 1 5 10 15 Leu <210> 598 <211> 14 <212> PRT <213> Rabbit <400> 598 Phe Pro Pro Gly Ser Asn Ser Gly Thr Asp Tyr Phe Asn Ile 1 5 10 <210> 599 <211> 9 <212> PRT <213> Rabbit <400> 599 Asp Asn Tyr Asp Trp Tyr Phe Asn Leu 1 5 <210> 600 <211> 14 <212> PRT <213> Rabbit <400> 600 Phe Pro Pro Gly Ser Asn Ser Gly Thr Asp Tyr Phe Asn Ile 1 5 10 <210> 601 <211> 16 <212> PRT <213> Rabbit <400> 601 Arg Asp Ala Asp Tyr Val Gly Phe Ile Trp Ala Tyr Tyr Phe Asn Leu 1 5 10 15 <210> 602 <211> 8 <212> PRT <213> Rabbit <400> 602 Gly Asn Pro Gly Trp Ala Ser Thr 1 5 <210> 603 <211> 15 <212> PRT <213> Rabbit <400> 603 Gly Val Val Ile Gly Asn Ala Tyr Ser Met Ala His Phe Ser Leu 1 5 10 15 <210> 604 <211> 17 <212> PRT <213> European rabbit <400> 604 Arg Leu Asn Tyr Val Thr Tyr Pro Ala Tyr Gly Tyr Gly Tyr Phe Asn 1 5 10 15 Leu <210> 605 <211> 11 <212> PRT <213> European rabb...

Claims

1. A monoclonal antibody or an antigen-binding fragment thereof, which is capable of binding to human IL-1R7, wherein the antibody comprises a) a VH region comprising the CDR1H region of SEQ ID NO: 309, the CDR2H region of SEQ ID NO: 457, and the CDR3H region of SEQ ID NO: 605, and b) a VL region comprising the CDR1L region of SEQ ID NO: 753, the CDR2L region of SEQ ID NO: 901, and the CDR3L region of SEQ ID NO: 1049 or 1205.

2. The antibody or antigen-binding fragment of claim 1, wherein the antibody comprises a heavy chain variable (VH) region that is at least 85% identical to the VH region of SEQ ID NO: 1189.

3. The antibody or antigen-binding fragment of any one of the preceding claims, wherein the antibody comprises a light chain variable (VL) region that is at least 85% identical to the VL region of SEQ ID NO: 1198 or 1203.

4. The antibody or antigen-binding fragment according to claim 1 or 2, wherein the antibody is a rabbit, rabbit / human chimeric or humanized antibody.

5. Use of the antibody or antigen-binding fragment according to any one of the preceding claims in the preparation of a medicament for treating an IL-18-mediated disease, wherein the disease is selected from the group consisting of type 1 or 2 diabetes, inflammatory bowel disease, multiple sclerosis, sarcoidosis, giant cell arteritis (GCA), age-related macular degeneration (AMD), chronic obstructive pulmonary disease (COPD), adult-onset Still's disease (AOSD), systemic juvenile idiopathic arthritis (SJIA), severe asthma, uveitis, geographic atrophy and atherosclerosis.

6. The use according to claim 5, wherein the inflammatory bowel disease comprises Crohn's disease (CD) or ulcerative colitis (UC).

7. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody or antigen-binding fragment according to any one of claims 1 to 4.

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