A Chinese medicine composition and preparation for treating sinusitis and nosebleed

Abstract

The invention discloses a Chinese medicine composition and preparation for treating sinusitis and nosebleed. The Chinese medicine composition and preparation mainly comprise the following raw materials by weight: 10-35 parts of Imperata cylindrica root, 10-20 parts of Semen Cassiae and 5-15 parts of Radix Rehmanniae. The invention innovatively selects Imperata cylindrica root and cooperates with Semen Cassiae to calm the liver and suppress yang, clear the liver and reduce the rising liver fire, and Radix Rehmanniae can nourish yin and moisten the lungs, and also has the effects of clearing the heat of the lungs and liver, and specializes in cooling blood and stopping bleeding, and promoting menstruation. The three Chinese medicine components cooperate together to act synergistically, and have significant therapeutic effects on treating nasal congestion, runny nose, nosebleed, acute and chronic rhinitis and sinusitis caused by unknown fire, damp-heat, phlegm and blood stasis, and have the advantages of small side effects, high cure rate and low recurrence rate.

Description

Technical Field

[0001] The invention relates to a Chinese medicine composition, in particular to a Chinese medicine composition and preparation for treating sinusitis and nosebleed, belonging to the field of Chinese medicine formula. Background Art

[0002] Traditional Chinese medicine has a long history. Chinese medicine calls nosebleed epistaxis, which is one of the common clinical symptoms. According to traditional Chinese medicine, the lung is the external orifice of the nose, the nose is above, connected to the throat below, and directly penetrates the lung. Therefore, when the exogenous wind heat or dryness heat leads to excessive heat in the lung, the "evil heat" will follow the meridians and stagnate in the nasal cavity, causing damage to the capillaries in the nasal cavity. Therefore, for those who drink too much, like spicy and greasy food, and cause blazing stomach fire, the heat will follow the meridians to inflame, damage the blood vessels in the nose, and cause nosebleeds. Getting angry can also be caused by excessive heat in the lungs and stomach, causing depression and anger, commonly known as "excessive liver fire", which damages the nasal orifice veins and leads to nosebleeds. Blood is the source of human life. If the nose bleeds for a long time, the patient will experience symptoms such as dizziness, nausea, loss of appetite, mental depression, weakness in the limbs, and even anemia, which seriously affects health.

[0003] Currently, the common method used by patients is to block the nostrils and apply ice / cold water to the neck, temporarily solving the problem of nosebleeds by blocking or lowering local blood pressure. This is only a temporary solution and does not address the root cause. Common Western medicine treatments result in a low cure rate and frequent relapses. This is a chronic disease that is difficult to treat and has a high recurrence rate.

[0004] Sinusitis is a common clinical disease with nasal congestion, purulent nasal discharge, dizziness, headache, and hyposmia. It belongs to the category of "nasal sinusitis" in traditional Chinese medicine and can occur at any age. In particular, chronic sinusitis has the characteristics of long course, complex condition, prolonged course, easy recurrence, and difficulty in cure. Although there are many clinical treatment methods, there is no special drug with special efficacy. In recent years, with the development of medicine, in-depth research on the etiology, pathogenesis and pathogenesis of sinusitis, and the widespread development of functional sinusitis surgery, although it has improved the ventilation and drainage of the nasal cavity and sinuses, restored the function of the nasal mucosa, and significantly improved the cure rate, there are characteristics such as high technical requirements and costs of sinus surgery, great pain for patients, and difficulty in grassroots implementation, and the efficacy of Western medicine alone is not good. Summary of the invention

[0005] The purpose of the present invention is to overcome the shortcomings of the existing western medicines in the prior art that it is difficult to cure nosebleeds and the recurrence rate is high, and the technical problems of sinusitis and recurrence, high surgical costs, and great pain for patients, and provide a Chinese medicine composition and preparation for treating sinusitis and nosebleeds. The Chinese medicine composition for treating nosebleeds of the present invention has significant therapeutic effects on the treatment of nasal congestion, runny nose, nosebleeds, acute and chronic rhinitis, and sinusitis caused by nameless fire, damp-heat, phlegm and blood stasis, has a high cure rate for nosebleeds, and has few side effects and a low recurrence rate; the use of the Chinese medicine composition of the present invention to treat sinusitis-like diseases has the advantages of being simple and easy, having obvious effects, low costs, and having no obvious adverse reactions, and can effectively avoid the disadvantages of high surgical costs and continuous pain for patients after surgery.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] A traditional Chinese medicine composition for treating sinusitis and nosebleed mainly comprises the following raw materials by weight: 10 to 35 parts of Imperata cylindrica root, 10 to 20 parts of Semen Cassiae, and 5 to 15 parts of Radix Rehmanniae.

[0008] According to the theoretical guidance of "Suwen. Qijue Lun" which says: "When the gallbladder transfers heat to the brain, it will cause nasal sinusitis. For nasal sinusitis, turbid mucus and cloudy mucus will not stop." and combined with clinical medication experience, the inventor has proposed a prescription composed of Semen Cassiae, Radix Rehmanniae, and Imperatae Rhizoma to treat nosebleed symptoms with the effects of clearing away heat and detoxification, reducing swelling and draining pus, and removing phlegm and turbidity. The present invention innovatively selects Imperatae Rhizoma, combined with Semen Cassiae, calming the liver and suppressing yang, clearing the liver and reducing the rising liver fire, and Radix Rehmanniae, nourishing yin and moistening the lungs, and also has the effect of clearing the heat of the lungs and liver, specializing in cooling blood and stopping bleeding, and dredges the menstruation. The Chinese medicine composition of the invention uses Imperata cylindrica, Semen Cassiae and Radix Rehmanniae as three important raw materials which act synergistically with each other, has significant therapeutic effects on treating nasal congestion, runny nose, nosebleed, acute and chronic rhinitis and sinusitis caused by unknown fire, damp-heat, phlegm and blood stasis, has a high cure rate for nosebleed, has little side effects and a low recurrence rate; using the Chinese medicine composition of the invention to treat sinusitis-like diseases has the advantages of being simple and easy to operate, having obvious effects, being low in cost and having no obvious adverse reactions, and can effectively avoid the disadvantages of high surgical costs and continuous pain of patients after surgery.

[0009] According to the Gansu Provincial Food and Drug Administration's "Gansu Province Tibetan Medicinal Materials Standard" (standard number: YCBZ2020-006), the root of Imperata cylindracea is cylindrical, slightly flat, often curved, 2.5-5mm in diameter, and 5-15cm long. The surface is yellowish white, light brownish yellow, slightly shiny, with few longitudinal wrinkles; the internodes are 0.5-1.6cm, and the nodes often have fibrous roots, hairs or scales. It is hard and brittle, with a grayish white cross section, small cracks in the skin, and pink around the holes; the center is the medullary cavity. It has a slight smell and a light taste; it tastes sweet and is cool in nature, and has the effects of clearing heat, relieving cough and relieving pain. Imperata cylindracea is the dried rhizome of Pennisetum longissimum SLChen etY.X.Jin var.intermedium SLChen et YXJin, a plant of the Poaceae family.

[0010] As auxiliary ingredients of Imperata cylindrica, Semen Cassiae and Radix Rehmanniae (i.e. Radix Rehmanniae) are selected in the formula of the present invention. Semen Cassiae has good liver-calming effect, and Radix Rehmanniae can mainly nourish yin and moisten the lungs, and clear lung heat. Epistaxis is more common in real heat syndrome. Although the site of onset is in the nose, it is closely related to the lungs, liver, spleen, and stomach, especially the lungs and liver. The liver is responsible for storing blood, which is a rigid organ with strong and urgent nature; liver fire goes up, disturbs the nasal cavity, and forces blood to overflow, with a large amount of bleeding and from time to time; the heat disturbs the clear cavity, resulting in headache, dizziness, tinnitus, bitter mouth, and dry throat; liver qi is stagnant, and the qi is not smooth, so the chest is stuffy and full, and irritable. The tongue and pulse are all signs of vigorous liver fire. The lungs are hot, and liver fire goes up, which can cause epistaxis.

[0011] Furthermore, the weight ratio of the Imperata cylindrica root to the Semen Cassiae is 1 to 3:1. Preferably, the weight ratio of the Imperata cylindrica root to the Semen Cassiae is 1.5 to 2.5:1. The inventors have found through a large number of experimental studies that the cure rate and total effective rate of sinusitis symptoms in patients are closely related to the weight ratio of the Imperata cylindrica root, the Semen Cassiae and the Radix Rehmanniae. The study found that when the weight ratio of the Imperata cylindrica root to the Semen Cassiae is 1.5 to 2.5:1, the cure rate of patients is higher.

[0012] Furthermore, the weight ratio of the Imperata grisea root to the Rehmannia glutinosa is 1 to 3: 1. The inventors have found through a large number of studies that the cure rate of sinusitis symptoms in patients is closely related to the weight ratio of the Imperata grisea root to the Rehmannia glutinosa root. The study found that when the weight ratio of the Imperata grisea root to the Rehmannia glutinosa root is 2.0 to 3: 1, the cure rate of patients is higher.

[0013] Further, 15 to 30 parts, 10 to 15 parts of Semen Cassiae, and 10 to 15 parts of Radix Rehmanniae. The inventor has found through a large number of experiments that the Chinese medicine composition under this important formula has a very good therapeutic effect on patients with epistaxis, and the cure rate is high.

[0014] Further, the raw materials also include heat-clearing and detoxifying components and / or honey; further, the heat-clearing and detoxifying components are at least one of Fritillaria, Bupleurum, Cortex Moutan, Radix Scutellariae, and Flos Chrysanthemi. Fritillaria, heat-clearing and moistening the lungs, resolving phlegm and relieving cough, the addition of Fritillaria to the Chinese medicine composition can coordinate the lung heat in the patient's body, enhance the therapeutic effect of the drug on epistaxis and sinusitis, and achieve the coordinated improvement of the patient's body function. Bupleurum can resolve the exterior and interior, soothe the liver, and raise yang. The application of Bupleurum can raise yang energy, restore the positive energy in the patient's body, and the positive energy can suppress damp-heat evil energy, and the patient's nosebleed and sinusitis symptoms can be further improved; the application of Cortex Moutan, Radix Scutellariae, and Flos Chrysanthemi can be a good auxiliary to clear blood heat, avoid blood heat and blood stasis, and make the vascular microcirculation of the nasal mucosa smoother, thereby achieving the effect of enhancing the therapeutic effect on epistaxis and sinusitis.

[0015] Furthermore, the heat-clearing and detoxifying component is 5 to 30 parts by weight.

[0016] Furthermore, the honey is in an amount of 1 to 10 portions.

[0017] The present invention also provides a decoction or honey pill prepared from the above-mentioned traditional Chinese medicine composition for treating nosebleed.

[0018] Furthermore, the decoction is prepared by the following method:

[0019] Step 1, according to the proportion, add water or alcohol to extract 1-5 times with Bupleurum, Scutellaria, Chrysanthemum, Radix Rehmanniae, Cortex Moutan, and Rhizoma Imperatae; combine the decoctions, concentrate to obtain a mixed decoction, and set aside;

[0020] Grind the stone cassia seed and Fritillaria thunbergii into powder according to the proportion to obtain mixed powder and set aside.

[0021] Step 2: Mix the mixed decoction, mixed powder and honey prepared in step 1, stir evenly to obtain a decoction.

[0022] The above preparation method includes all the components and raw materials for clearing away heat and detoxifying, namely, Fritillaria, Bupleurum, Cortex Moutan, Baical Scutellariae, and Chrysanthemum. In the actual preparation process, the components for clearing away heat and detoxifying may or may not be added. If added, one or more of the above raw materials may be added.

[0023] The method for preparing a Chinese medicine composition decoction of the present invention realizes targeted processing of Chinese medicine component raw materials of different properties according to the characteristics of the medicine, so that the efficacy of various Chinese medicine components can be more fully exerted, and can be better applied to the treatment of nosebleeds and sinusitis.

[0024] Furthermore, in step 1, the amount of water or alcohol added is 1-6 times the total mass of the medicinal material. Generally, the amount is based on completely immersing the medicinal material. The water or alcohol solution that fully immerses the medicinal material can well achieve the extraction process of the drug.

[0025] Furthermore, the alcohol is the alcohol solution which is 20-70% (volume ratio) of ethanol in water.

[0026] Preferably, the extraction solution is an aqueous solution, which can better interact with the medicinal materials when used as an extracting solution to promote the dissolution of the medicinal components therein. In addition, the aqueous solution is also easier to concentrate in the subsequent concentration process, which can reduce the energy consumption of subsequent processing.

[0027] Further, in step 1, the stone cassia seed and the Fritillaria thunbergii are ground into powder, and the powder is then passed through a 40-200 mesh sieve.

[0028] Furthermore, the honey pills are prepared by the following method:

[0029] Step A, according to the proportion, add water or alcohol to extract 1-5 times of Bupleurum, Scutellaria, Chrysanthemum, Radix Rehmanniae, Cortex Moutan, and Imperatae Grisea, combine the decoctions, concentrate to obtain a mixed paste or dry powder, and set aside;

[0030] Grind the stone cassia seed and Fritillaria thunbergii into powder according to the proportion to obtain mixed powder and set aside.

[0031] Step B: Mix the mixed paste / dry powder, mixed powder and honey prepared in step A to make honey pills.

[0032] The above preparation method includes all the components and raw materials for clearing away heat and detoxifying, namely, Fritillaria, Bupleurum, Cortex Moutan, Baical Scutellariae, and Chrysanthemum. In the actual preparation process, the components for clearing away heat and detoxifying may or may not be added. If added, one or more of the above raw materials may be added.

[0033] The preparation method is simple to operate and can maximize the efficacy of the traditional Chinese medicine components, so that the honey pills have a better taste.

[0034] Furthermore, in step A, the amount of water or alcohol added is 1-6 times the weight of the medicinal material. Generally, the amount is based on completely immersing the medicinal material. The water or alcohol solution that fully immerses the medicinal material can well achieve the extraction process of the drug.

[0035] Furthermore, the alcohol is the alcohol solution which is 20-70% (volume ratio) of ethanol in water.

[0036] Preferably, the extraction solution is an aqueous solution, which can better interact with the medicinal materials when used as an extracting solution to promote the dissolution of the medicinal components therein. In addition, the aqueous solution is also easier to concentrate in the subsequent concentration process, which can reduce the energy consumption of subsequent processing.

[0037] Furthermore, in step A, the density of the mixed paste obtained by concentration is 1.1-1.5 g / ml. By properly retaining some water, the paste of the Chinese medicine decoction is easier to mix evenly when honey is added to make honey pills, and the honey pills made are more stable.

[0038] Furthermore, in step A, the stone cassia seed and the Fritillaria thunbergii are ground into powder, and the powder is then passed through a 40-200 mesh sieve.

[0039] Compared with the prior art, the present invention has the following beneficial effects:

[0040] 1. The present invention innovatively selects Imperata cylindrica root and cooperates with Semen Cassiae to soothe the liver and suppress yang, clear the liver and reduce the rising liver fire, solve the root cause of nosebleeds, and Radix Rehmanniae Root nourishes yin and moistens the lungs, and also has the effect of clearing the heat of the lungs and liver, specializing in cooling blood and stopping bleeding, and dredges the menstruation. The three Chinese medicinal ingredients work together synergistically to treat nasal congestion, runny nose, nosebleed, acute and chronic rhinitis, and sinusitis caused by unknown fire, damp-heat, phlegm and blood stasis, and have significant therapeutic effects, and have the advantages of small side effects, high cure rate and low recurrence rate. The cure rate of sinusitis can reach more than 75%, the cure rate of nosebleed can reach more than 80%, and the total effective rate is more than 90%.

[0041] 2. The Chinese medicine composition of the present invention also includes Fritillaria, which clears away heat and moistens the lungs; Bupleurum, which harmonizes the exterior and interior and relieves the liver; promotes the therapeutic effect of the Chinese medicine composition, coordinates the lung heat in the patient's body, achieves the coordinated improvement of the patient's body function, and achieves the purpose of radical cure, and also includes Cortex Moutan, Radix Scutellariae, and Flos Chrysanthemi. It can clear away heat and cool blood, purge fire and detoxify, clear liver fire, and disperse wind-heat. It makes the vascular microcirculation of the nasal mucosa smoother, enhances the therapeutic effect on epistaxis, and the inventor unexpectedly found that the important formula of the present invention has the effect of alleviating symptoms and curing patients with chronic sinusitis, and has the advantage of no obvious adverse reactions, which can effectively avoid the high cost of surgery and the disadvantages of continuous pain of patients after surgery.

[0042] 3. The present invention also provides a method for preparing decoctions and honey pills using the Chinese medicine composition provided by the present invention. The preparation method is simple and can fully exert the efficacy of the drug components through targeted processing according to the characteristics of the drug. DETAILED DESCRIPTION

[0043] The present invention is further described in detail below in conjunction with test examples and specific implementation methods. However, this should not be understood as the scope of the above subject matter of the present invention being limited to the following embodiments, and all technologies realized based on the content of the present invention belong to the scope of the present invention.

[0044] Note: All percentages not specifically stated in the present invention are weight percentages, and ethanol solutions or alcohol are usually mixed liquids of ethanol and water in a volume ratio or pure ethanol liquids. The Imperata grisea used in the present invention are Imperata grisea roots collected and cleaned, and Imperata grisea roots dried after the surface moisture is dried.

[0045] The Imperatae Grisea, Semen Cassiae, Radix Rehmanniae, Bulbus Fritillariae, Radix Bupleuri, Cortex Moutan, Radix Scutellariae, Flos Chrysanthemi, and honey used in the following examples of the present invention were all purchased commercially.

[0046] Example 1

[0047] The Chinese medicine composition has the following weight ratios: 30g Imperatae cylindrica, 15g Cassia seed and 10g Radix Rehmanniae.

[0048] Embodiment 2-7

[0049] In Example 2-7, a series of research and exploration were conducted on the influence of the weight ratio of Imperata cylindrica to Semen Cassiae on the physical and medicinal efficacy of the Chinese medicine composition. The Chinese medicine combination formula of Example 2-7 is the same as that of Example 1, and is composed of Imperata cylindrica, Radix Rehmanniae and Semen Cassiae; the total mass of Imperata cylindrica and Semen Cassiae in Example 2-7 is 45g, and only the weight ratio of Imperata cylindrica to Semen Cassiae is changed as shown in Table 1. The amount of Radix Rehmanniae in Example 2-7 is 10g, which is the same as that in Example 1. Some experiments were conducted on the medicinal efficacy of the Chinese medicine composition of Example 2-7 in the process of treating sinusitis symptoms. The experimental process is shown in Test Example 1, and the results are shown in Table 1.

[0050] Examples 8-12

[0051] In Examples 8-12, a series of research and exploration were conducted on the effect of the weight ratio of Imperata cylindrica to Radix Rehmanniae on the physical and medicinal efficacy of the Chinese medicine composition. The Chinese medicine combination formula of Examples 8-12 is the same as that of Example 1, and is composed of Imperata cylindrica, Radix Rehmanniae and Semen Cassiae; the total mass of Imperata cylindrica and Radix Rehmanniae in Examples 8-12 is 40g, and only the weight ratio of Imperata cylindrica to Radix Rehmanniae is changed as shown in Table 1. The amount of Semen Cassiae in Examples 8-12 is 15g, which is the same as that in Example 1. Some experiments were conducted on the medicinal efficacy of the Chinese medicine composition of Examples 8-12 in the treatment of sinusitis symptoms. The experimental process is shown in Test Example 1, and the results are shown in Table 1.

[0052] Embodiment 13

[0053] The Chinese medicine composition has the following weight proportions: 30g Imperatae cylindrica, 15g Semen Cassiae, 10g Radix Rehmanniae, 3g Scutellariae Baicalensis, 2g Chrysanthemum and 4g Fritillariae Bulb.

[0054] Embodiment 14

[0055] The Chinese medicine composition has the following weight proportions: 30g Imperatae Rhizoma, 15g Semen Cassiae, 10g Radix Rehmanniae, 2g Bupleurum, 2g Scutellariae Baicalensis, and 2g Chrysanthemum.

[0056] Comparative Example 1

[0057] The Chinese medicine composition has the following weight proportions: 30g Imperata root, 15g Semen Cassiae, and 10g Radix Rehmanniae.

[0058] Comparative Example 2

[0059] The Chinese medicine composition has the following weight ratio: 36.7g Imperata cylindrica and 18.3g Cassia tora.

[0060] Comparative Example 3

[0061] The Chinese medicine composition has the following weight ratio: 41.25g Imperata cylindrica and 13.75g Rehmannia glutinosa.

[0062] Test Example 1

[0063] 1. Study subjects: Patients diagnosed with chronic sinusitis in outpatient and inpatient settings of a hospital.

[0064] Research method: 180 patients who met the diagnostic criteria for chronic sinusitis were selected and treated on a voluntary basis. They were randomly divided into 18 groups, with 10 patients in each group. The 18 groups were basically balanced in terms of average age, course of disease, and condition, and were comparable. Groups 1-17 were respectively made of the corresponding Chinese medicine formulas of Example 1, Example 2-7, Example 8-14, and Comparative Example 1-3, and 3g of the honey pills were taken with warm water each time, 3 times / day for treatment; Group 18 was the control group: treated with antibiotics (macrolides: roxithromycin) for 2 months.

[0065] The preparation method of honey pills is as follows:

[0066] According to the proportion, add water to bupleurum, scutellaria, chrysanthemum, raw rehmannia, moutan bark and imperata root for 3 times of reflux extraction, combine the decoctions, concentrate and dry to obtain the first mixed powder; grind cassia bark and fritillaria according to the proportion to obtain the second mixed powder, and set aside; mix the first mixed powder and the second mixed powder evenly, add honey, stir and mix, and make honey pills of 0.5 g each.

[0067] 2. Diagnostic criteria

[0068] Refer to the guidelines for diagnosis and treatment of allergic rhinitis developed by the Rhinology Group of the Editorial Board of the Chinese Journal of Otorhinolaryngology-Head and Neck Surgery, the Rhinology Group of the Otorhinolaryngology-Head and Neck Surgery Branch of the Chinese Medical Association, the "Guiding Principles for Clinical Research of New Chinese Medicines" and the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes".

[0069] 2.1. Western medicine diagnostic criteria

[0070] 2.1.1. Symptoms: 1) Main symptoms: nasal congestion, sticky, purulent nasal discharge.

[0071] 2) Secondary symptoms: swelling and pain in the head and face, decreased or loss of sense of smell.

[0072] The diagnosis is based on two or more of the above-mentioned related symptoms, among which one of the main symptoms must be nasal congestion or sticky, purulent nasal discharge.

[0073] 2.1.2. Examination: 1) Nasal examination: mucopurulent secretions from the middle nasal meatus and olfactory fissure, congestion, edema or polyps of the middle nasal meatus mucosa.

[0074] 2) Imaging examination: CT scan shows lesions of the ostiomeatal complex or nasal mucosa.

[0075] 2.2. TCM diagnostic criteria

[0076] 1) The main symptoms are a lot of sticky or purulent nasal discharge, nasal congestion, headache or dizziness. Acute sinusitis is accompanied by fever and general discomfort.

[0077] 2) Acute sinusitis develops quickly and lasts for a short time. If not treated thoroughly, it will turn into chronic sinusitis with a longer course.

[0078] 3) Nasal examination shows congestion and swelling of the mucosa, and a lot of sticky or purulent secretions in the nasal cavity or posterior nasal cavity.

[0079] 4) X-ray sinusography shows positive results. In acute attacks, the total white blood cell count and neutrophil count increase.

[0080] 3. Efficacy criteria: Cured: symptoms disappear, and X-ray sinus films show no abnormalities; Improved: symptoms are significantly improved, nasal examination shows that congestion, mucosal swelling and other manifestations are alleviated, and X-ray sinus films show significant improvement; Ineffective: symptoms and signs are not improved.

[0081] 4. Safety evaluation determines the degree of clinical adverse reactions and the relevance of the drugs used, through safety observation, including general physical examination items; blood, urine, and stool routine tests; heart, liver, and kidney function tests; and corresponding safety checks based on possible toxic and side effects of the drugs. The evaluation is based on the criteria of definitely related, very likely related, possibly related, possibly unrelated, and unrelated. The first three are adverse reactions, and the incidence of adverse reactions is counted.

[0082] 5. Statistical processing of count data using X 2 The measurement data were analyzed using t test.

[0083] Table 1 Results of the study on the efficacy of Chinese medicine composition on sinusitis symptoms

[0084]

[0085]

[0086] From the research results in Table 1, when treating the symptoms of sinusitis, the weight ratio of Imperata cylindrica to Lithospermum officinale and the weight ratio of Imperata cylindrica to Radix Rehmanniae both have an important influence on the effect of treating sinusitis. The study found that when the weight ratio of Imperata cylindrica to Lithospermum officinale is 1 to 3:1, the cure rate of patients with sinusitis can reach more than 60%, and the total effective rate (cure rate plus improvement rate) can reach more than 100%. Preferably, the weight ratio of Imperata cylindrica to Lithospermum officinale is 1.5 to 2.5:1. When the weight ratio of Imperata cylindrica to Radix Rehmanniae is 0.5:1 and 4:1, the cure rate and the total effective rate are reduced. Preferably, the weight ratio of Imperata cylindrica to Radix Rehmanniae is 1 to 3:1. The important formula of the present invention has the advantages of alleviating symptoms and curing sinusitis patients, and has no obvious adverse reactions, which can effectively avoid the disadvantages of high surgical costs and continuous pain of patients after surgery. At the same time, compared with the research results of Example 1, it can be seen from the research results of Example 13 and Example 14 that adding some heat-clearing and detoxifying ministerial drugs on the basis of the main raw materials is beneficial to coordinating the patient's body heat, enhancing the efficacy of the main raw materials, and assisting in clearing heat and detoxifying, thereby improving the overall effective rate for treating nosebleeds.

[0087] The difference between Comparative Example 1 and Example 1 is that Comparative Example 1 replaces Imperata cylindrica root with Imperata cylindrica root to treat sinusitis. Studies have found that the combination of Imperata cylindrica root, Radix Rehmanniae and Semen Semen has no therapeutic effect on sinusitis, but only has some alleviating effect; Compared with Example 1, Comparative Example 2 and Comparative Example 3 remove the Radix Rehmanniae and Comparative Example 3 remove the Semen Semen. The results of the study found that the efficacy of the traditional Chinese medicine composition without the Radix Rehmanniae and Semen Semen was greatly reduced. The traditional Chinese medicine composition provided by the present invention has a significant therapeutic effect on the treatment of acute and chronic rhinitis and sinusitis caused by damp-heat, phlegm and blood stasis under the synergistic effect of Imperata cylindrica root, Radix Rehmanniae and Semen Semen, and has the advantages of small side effects, high cure rate and low recurrence rate.

[0088] Embodiment 15

[0089] The Chinese medicine composition has the following weight ratios: 30g Imperatae cylindrica, 15g Cassia seed and 10g Radix Rehmanniae.

[0090] Step 1, 30g Imperatae cylindricae, 10g Radix Rehmanniae glutinosae and 6 times the total weight of the medicinal materials were added to reflux and extract for 3 times, the decoctions were combined, concentrated to obtain a mixed decoction, and set aside;

[0091] Grind 15g of Cassia seed into powder, pass through a 150-mesh sieve to obtain powder for later use;

[0092] Step 2: Mix the mixed decoction prepared in step 1, the powder and 1 part of honey, stir evenly to obtain a decoction.

[0093] Example 16

[0094] The Chinese medicine composition has the following weight ratio: 20g Imperatae cylindrica, 10g Cassia seed and 10g Radix Rehmanniae.

[0095] Step 1, 20g Imperatae cylindricae, 10g Radix Rehmanniae glutinosae and 6 times the total weight of the medicinal materials were added to reflux and extract for 3 times, the decoctions were combined, concentrated to obtain a mixed decoction, and set aside;

[0096] Grind 10g of Cassia tomentosa into powder, and pass through a 150-mesh sieve to obtain powder for later use;

[0097] Step 2: Mix the mixed decoction prepared in step 1, the powder and 1 part of honey, stir evenly to obtain a decoction.

[0098] Embodiment 17

[0099] The Chinese medicine composition has the following weight ratio: 15g Imperatae cylindrica, 10g Cassia seed and 8g Radix Rehmanniae.

[0100] Step 1, 15g Imperatae cylindricae, 8g Radix Rehmanniae glutinosae and 6 times the total weight of the medicinal materials were added to reflux and extract for 3 times, the decoctions were combined, concentrated to obtain a mixed paste, and set aside;

[0101] Grind 10g of Cassia tomentosa into powder, and pass through a 100-mesh sieve to obtain a mixed powder for later use;

[0102] Step 2: Mix the mixed decoction prepared in step 1, the mixed powder and 1 part of honey to prepare honey pills.

[0103] Embodiment 18

[0104] The Chinese medicine composition has the following weight proportions: 30g Imperatae cylindrica, 15g Semen Cassiae, 10g Radix Rehmanniae, 3g Scutellariae Baicalensis, 2g Bupleurum, and 4g Fritillariae Bulb.

[0105] Step 1, 30g Imperatae Rhizoma, 10g Radix Rehmanniae, 3g Radix Scutellariae, 2g Radix Bupleuri were added with water 6 times of the total weight of the medicinal materials and refluxed and extracted 3 times, the decoctions were combined, concentrated to obtain a mixed paste, and set aside;

[0106] Grind 15g of Cassia seed and 4g of Fritillaria thunbergii into powder, sieve through a 100-mesh sieve to obtain a mixed powder for later use;

[0107] Step 2: Mix the mixed decoction prepared in step 1, the mixed powder and 1 part of honey to prepare honey pills.

[0108] Embodiment 19

[0109] The Chinese medicine composition has the following weight proportions: 30g Imperatae cylindrica, 15g Semen Cassiae, 10g Radix Rehmanniae, 2g Radix Bupleuri, 3g Radix Scutellariae, and 2g Chrysanthemum.

[0110] Step 1, 30g Imperatae Rhizoma, 10g Radix Rehmanniae, 2g Radix Bupleuri, 3g Radix Scutellariae, 2g Flos Chrysanthemi are added with water 6 times the total weight of the medicinal materials and refluxed and extracted 3 times, the decoctions are combined, concentrated to obtain a mixed decoction, and set aside;

[0111] Grind 15g of Cassia seed into powder, pass through a 150-mesh sieve to obtain powder for later use;

[0112] Step 2: Mix the mixed decoction prepared in step 1, the powder and 1 part of honey, stir evenly to obtain a decoction.

[0113] Test Example 2

[0114] 90 outpatients were admitted, all of whom were diagnosed with nosebleeds according to the diagnosis and efficacy standards of TCM diseases in the TCM industry standards of the People's Republic of China issued by the State Administration of Traditional Chinese Medicine. They were treated on a voluntary basis and randomly divided into nine groups, namely, 10 patients in treatment group A, 10 patients in treatment group B, 10 patients in treatment group C, 10 patients in treatment group D, 10 patients in treatment group E, 10 patients in comparison group 1, 10 patients in comparison group 2, 10 patients in comparison group 3, and 10 patients in control group. The nine groups of patients were basically balanced in terms of average age, course of disease, and condition, and were comparable.

[0115] The patients in the treatment AE group were treated with the preparations prepared in Examples 15-19 for one month, and the comparative example 1 group to the comparative example 3 group were treated with the preparations prepared in Comparative Examples 1-3, respectively. The patients in the control group were treated with commercially available drugs for treating nosebleeds for the same period of time. After one month of treatment, the efficacy of the patients in the treatment AE group and the control group was evaluated, and the evaluation results are shown in Table 2.

[0116] The evaluation criteria are divided into cured, markedly effective, and ineffective. Cured means that the patient no longer has nasal bleeding and has no recurrence for 2 years. Markedly effective means that the patient has nasal discomfort and bleeding symptoms. Ineffective means that the patient still has frequent nasal bleeding and the symptoms have not improved.

[0117] Table 2 Comparison of efficacy between the AE treatment group and the control group

[0118] Group Number of patients Number of people cured Number of people with significant effect Invalid number of people Cure rate / % Total effective rate / % Treatment Group A 10 8 2 0 80 100 Treatment Group B 10 7 2 1 70 90 Treatment Group C 10 7 1 2 70 80 Treatment Group D 10 9 1 0 90 100 Treatment Group E 10 9 1 0 90 100 Comparative Example 1 10 3 5 2 30 50 Comparative Example 2 10 4 2 4 40 60 Comparative Example 3 10 4 4 4 40 60 Control group 10 2 5 3 20 64

[0119] From the research results in Table 2, it is found that the cure rate and the total effective rate of the patients in the treatment group AE are significantly higher than those in the control group. From the data in Table 2, the cure rate of nosebleeds in the treatment group can reach more than 70%, among which the cure rate and the total effective rate of the treatment group A and the treatment group B are higher than those of the treatment group C. When treating patients with nosebleeds, the preferred Chinese medicine composition is 15 to 30 parts of Imperata cylindrica, 10 to 15 parts of Semen Cassiae, and 10 to 15 parts of Radix Rehmanniae; from the research results of the treatment groups D and E in Table 2, it is found that after adding some heat-clearing and detoxifying components on the basis of the main raw materials of the treatment group A of the present invention, the cure rate of the patients remains basically unchanged and can reach more than 90%, and the total effective rate of the patients in the treatment groups D and E is improved. Adding some heat-clearing and detoxifying ministers on the basis of the main raw materials is beneficial to coordinate the patient's body heat, enhance the efficacy of the main raw materials, and assist in clearing heat and detoxifying, thereby improving the total effective rate of treating nosebleeds.

[0120] The difference between Comparative Example 1 and Example 1 is that in Comparative Example 1, Imperata root is replaced with Imperata root to treat nosebleed. Studies have found that the therapeutic effect of Imperata root, Radix Rehmanniae and Semen Semen on nosebleed is far inferior to that of the Chinese medicine composition provided by the present invention; Compared with Example 1, Comparative Example 2 and Comparative Example 3 remove the Radix Rehmanniae and Comparative Example 3 remove the Semen Semen. The results of the study found that the efficacy of the Chinese medicine composition without the Radix Rehmanniae and Semen Semen was greatly reduced. The Chinese medicine composition provided by the present invention has a significant therapeutic effect on the treatment of nosebleed caused by nameless fire under the synergistic effect of Imperata root, Radix Rehmanniae and Semen Semen.

[0121] Comparative Example 4

[0122] The Chinese medicine composition has the following weight ratios: 30g Imperatae cylindrica, 15g Cassia seed and 10g Radix Rehmanniae.

[0123] Preparation of honey pills

[0124] According to the proportion, add ethanol to the raw rehmannia root and the root of Imperata cylindrica for 3 times of reflux extraction, combine the decoction, concentrate and dry to obtain the first mixed powder; grind the Cassia Cassiae to powder according to the proportion to obtain the second mixed powder for standby use; mix the first mixed powder and the second mixed powder evenly, add honey, stir and mix, and make honey pills of 0.5g each. The ethanol is a 60% (volume ratio) ethanol aqueous solution.

[0125] test

[0126] The subjects were patients diagnosed with chronic sinusitis in the outpatient and inpatient departments of the same hospital as in Example 1.

[0127] Ten patients who met the diagnostic criteria for chronic sinusitis were selected and treated on a voluntary basis. Each time, 3 g of honey pills were taken with warm water, 3 times a day, for 2 months.

[0128] The same diagnostic criteria as in Experimental Example 1 were used for diagnosis, and the diagnostic results are shown in Table 3.

[0129] Comparative Example 5

[0130] The Chinese medicine composition has the following weight ratios: 30g Imperatae cylindrica, 15g Cassia seed and 10g Radix Rehmanniae.

[0131] Step 1, 30g Imperatae cylindricae and 10g Radix Rehmanniae were added with 6 times the total weight of ethanol to extract 3 times, the decoctions were combined, concentrated to obtain a mixed decoction, and set aside;

[0132] Grind 15g of Cassia seed into powder, pass through a 150-mesh sieve to obtain powder for later use;

[0133] Step 2: Mix the mixed decoction prepared in step 1, the powder and 1 portion of honey, stir evenly to obtain a decoction, wherein the ethanol is a 60% (volume ratio) ethanol aqueous solution.

[0134] Ten outpatients who were the same as those in Experimental Example 2 were admitted. All patients were diagnosed with nosebleeds according to the diagnostic and therapeutic efficacy standards of TCM diseases in the TCM industry standards of the People's Republic of China issued by the State Administration of Traditional Chinese Medicine. The patients were treated on a voluntary basis. The patients were basically balanced in terms of average age, course of disease, and condition, and were comparable. Each patient took the decoction for one month; the diagnosis was made using the same diagnostic criteria as in Experimental Example 2, and the diagnostic results are shown in Table 3.

[0135] Table 3 Diagnostic results statistics

[0136]

[0137] From the test results in Table 3, it is found that compared with ethanol extraction of the Chinese medicine composition of the present invention, the aqueous solution when used as the extract can better interact with the medicinal materials, promote the dissolution of the medicinal components therein, and enable the Chinese medicine composition to exert a better medicinal effect.

[0138] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating sinusitis and nosebleed, characterized in that: The method is prepared from the following raw materials in parts by weight: 10 to 35 parts of Imperata cylindrica, 10 to 20 parts of Semen Cassiae, and 5 to 15 parts of Radix Rehmanniae; The weight ratio of the Imperata cylindrica to the Semen Cassiae is 1 to 3:1; The weight ratio of the Imperata cylindrica root to the Rehmannia glutinosa is 1 to 3:

1.

2. The Chinese medicine composition for treating sinusitis and nosebleed according to claim 1, characterized in that: The weight ratio of the Imperata cylindrica to the Semen Cassiae is 1.5-2.5:

1.

3. The Chinese medicine composition for treating sinusitis and nosebleed according to claim 1, characterized in that: 15-30 parts of Imperata cylindrica, 10-15 parts of Semen Cassiae, and 10-15 parts of Rehmannia glutinosa.

4. A Chinese medicine composition for treating sinusitis and nosebleed, characterized in that: On the basis of the Chinese medicine composition described in claim 1, the raw material is further added with heat-clearing and detoxifying components and / or honey; The heat-clearing and detoxifying component is 5 to 30 parts, and the honey is 1 to 10 parts; The heat-clearing and detoxifying component is one or more of Fritillaria, Bupleurum, Cortex Moutan, Baical Scutellaria and Chrysanthemum.

5. A decoction prepared from the Chinese medicinal composition for treating nosebleeds and sinusitis according to claim 4, characterized in that: The decoction is prepared by the following method: Step 1, according to the proportion, add water or alcohol to extract 1-5 times with Bupleurum, Scutellaria, Chrysanthemum, Radix Rehmanniae, Cortex Moutan, and Rhizoma Imperatae; combine the decoctions, concentrate to obtain a mixed decoction, and set aside; Grind the stone cassia seed and the fritillaria thunbergii into powder according to the proportion to obtain a mixed powder for later use; Step 2: Mix the mixed decoction, mixed powder and honey prepared in step 1, stir evenly to obtain a decoction.

6. A honey pill prepared from the Chinese medicine composition for treating nosebleeds and sinusitis according to claim 4, characterized in that: The honey pill is prepared by the following method: Step A, according to the proportion, add water or alcohol to extract 1-5 times of Bupleurum, Scutellaria, Chrysanthemum, Radix Rehmanniae, Cortex Moutan, and Imperatae Grisea, combine the decoctions, concentrate to obtain a mixed paste or dry powder, and set aside; Grind the stone cassia seed and the fritillaria thunbergii into powder according to the proportion to obtain a mixed powder for later use; Step B: Mix the mixed paste / dry powder, mixed powder and honey prepared in step A to make honey pills.

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