Display panel with pre-patterned image

Abstract

The present invention relates to an active molecule delivery system, which comprises a plurality of microwells, wherein each microwell has a bottom, a panel having a first region and a second region, and the microwells in the first region have substantially the same bottom thickness and the microwells in the second region have an increased bottom thickness. Such a panel is useful for many applications such as drug administration.

Description

[0001] This application claims the benefit of application serial number 16 / 100,528 filed on August 10, 2018. Field of the Invention

[0002] The present invention relates to a display panel with a pre-patterned image. Such a panel has a variety of applications, such as logo displays with a fixed image pattern or watermark features to protect against counterfeiting or simply for decorative purposes. SUMMARY OF THE INVENTION

[0004] The present invention relates to an active molecule delivery system, which includes micropores filled with an electrophoretic fluid, wherein each micropore has a bottom and one surface of the bottom is in contact with the electrophoretic fluid, a display panel has a first area and a second area, and the micropores in the first area have substantially the same bottom thickness, and the micropores in the second area have an increased bottom thickness.

[0005] In one embodiment, the bottom thickness of the microwells in the second region is 0.001 micrometers to 9 / 10 of the depth of the microwells in the first region, which is greater than the bottom thickness of the microwells in the first region.

[0006] In one embodiment, the bottom thickness of the microwells in the second region is 0.001 micrometers to 1 / 2 of the depth of the microwells in the first region, which is greater than the bottom thickness of the microwells in the first region.

[0007] In one embodiment, the bottom thicknesses of the microwells in the second region are not the same.

[0008] In one embodiment, the electrophoretic fluid filled in the microwells in both the first region and the second region comprises one type of charged particles dispersed in a solvent or a solvent mixture. In another embodiment, the electrophoretic fluid filled in the microwells in the first and second regions comprises two types of charged particles dispersed in a solvent or a solvent mixture. In another embodiment, the electrophoretic fluid filled in the microwells in the first and second regions comprises more than two types of charged particles dispersed in a solvent or a solvent mixture.

[0009] In one embodiment, the active molecule delivery system is sandwiched between two electrode layers. In one embodiment, the two electrode layers are non-patterned conductive layers. In another embodiment, one of the electrode layers is a common electrode layer, and the other electrode layer is a thin film transistor matrix drive system or a segmented backplane drive system.

[0010] In one embodiment, the display panel is used for bar codes, anti-counterfeiting labels, direction signs or shelf labels. In another embodiment, the display panel is used in watermarking applications.

[0011] Another aspect of the present invention relates to a method for preparing the active molecule delivery system of the present invention, comprising:

[0012] a) providing a roller having an engraved area on its surface to form a pattern, the pattern being a positive or negative image of a desired pattern for a display panel;

[0013] b) applying an embossable composition to the substrate layer on the surface of the roller; and

[0014] c) Applying a positive mold on the embossable composition.

[0015] In one embodiment, the engraved areas have different depths.

[0016] In one embodiment, the substrate layer is attached to the electrode layer.

[0017] Another aspect of the present invention relates to a method for preparing the active molecule delivery system of the present invention, comprising:

[0018] a) providing micropores;

[0019] b) filling the micropores in predetermined areas with a chemical composition in a solvent;

[0020] c) removing the solvent; and

[0021] d) curing the chemical composition, optionally after removing the solvent.

[0022] In one embodiment, the solvent is methyl ethyl ketone, acetone or isopropanol. In one embodiment, the micropores are filled with chemical compositions of varying concentrations. In one embodiment, the concentration is 0.01 wt % to 90 wt %. In one embodiment, the concentration is 0.01 wt % to 50 wt %.

[0023] In one embodiment, the chemical composition is different from the composition forming the micropores. In another embodiment, the chemical composition is the same as the composition forming the micropores. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 A display panel including a pre-patterned image is shown.

[0026] Figure 2 is a cross-sectional view of a micropore.

[0027] Figure 3 The display panel of the present invention is shown in which micro-holes in one area have thicker bottoms than micro-holes in another area.

[0028] 4A and 4B illustrate an imprinting process for making microwells.

[0029] Figure 5 A method for preparing the display panel of the present invention is shown.

[0030] Figure 6 An alternative method for preparing the display panel of the present invention is shown.

[0031] Figure 7 The display panel of the invention is shown sandwiched between two electrode layers.

[0032] Figure 8 It is shown how different levels of color intensity can be achieved by the display panel of the invention.

[0033] Fig. 9 An alternative design of the invention is shown.

[0034] Fig.10 An embodiment of an active molecule delivery system comprising a plurality of microwells comprising a porous diffusion layer is shown, wherein different microwells have different volumes. DETAILED DESCRIPTION OF THE INVENTION

[0036] A first aspect of the invention relates to a display panel comprising a pre-patterned image. Figure 1 It is a top view of a display panel (10) including microholes (10a) on which a pre-patterned image "8" (11) appears. Therefore, the display panel has a patterned area (11) and a background area (ie, an area outside the patterned area).

[0037] Figure 2 is a cross-sectional view of micropores (20). Each micropore has a bottom (21), and the micropore is filled with a display fluid (22). The inner surface or top surface (21a) of the bottom is in direct contact with the display fluid.

[0038] In one embodiment, the term "microwell" may be a cup-shaped microcontainer such as those described in U.S. Pat. No. 6,930,818.

[0039] Figure 3 is a cross-sectional view of micropores in a display panel of the present invention. The panel has a first region and a second region. In the context of the present application, the term "first region" refers to a region in which micropores (30b) have substantially the same bottom thickness, and the term "second region" refers to a region in which micropores (30a) have a bottom thicker than the bottom of the micropores in the first region. The term "substantially the same" means that the thickness variation is within a manufacturing tolerance, for example, ±5%.

[0040] The micropores (30a) in the second region have an increased thickness "t", which can be 0.001 micron to 9 / 10 of the depth ("d") of the micropores in the first region (wherein the depth of the micropores is substantially uniform), preferably 0.001 micron to 1 / 2 of the depth of the micropores in the first region. In other words, the bottom thickness of the micropores in the second region is 0.001 micron to 9 / 10 of the depth of the micropores in the first region, preferably 0.001 micron to 1 / 2 of the depth of the micropores in the first region, which is greater than the bottom thickness of the micropores in the first region.

[0041] The second area may be a patterned area while the first area is a background area, or vice versa.

[0042] The increased bottom thicknesses in the various microwells in the second region do not have to be the same. Some of them may be thicker than others.

[0043] The display panel of the present invention can be prepared by various methods.

[0044] Fig. 4A and 4B illustrate the embossing process as described in U.S. Pat. Nos. 6,831,770 and 6,930,818. As shown, first, an embossable composition (40) is coated on a substrate layer (41). The substrate layer is on a roller (42). A male mold (43) is pressed on the embossable composition to form micropores (44). The embossable composition for forming micropores can be hardened during or after the male mold is released. In this method, the micropores have a substantially uniform bottom thickness.

[0045] Optionally, there may be an electrode layer attached to the substrate layer (41). When an electrode layer is present, the embossable composition is applied to the electrode layer side. In this case, the electrode layer will be one of the two layers sandwiching the display panel in the final product.

[0046] When an electrode layer is not present in the process, the substrate layer attached to the resulting display panel can be removed after the imprinting process and replaced with an electrode or another substrate layer.

[0047] In order to prepare a display panel having a pre-patterned image, by rolling the roller (52) (see Figure 5 ) to form a pattern that may be a "positive" image or a "negative" image of the desired pattern of the display panel, the method shown in Figures 4A and 4B is modified.

[0048] In the embossing process, the pressure applied by the male mold on the embossable composition in the engraved area is less than the pressure applied by the male mold on the embossable composition in other areas. As a result, the bottom of the micropores corresponding to the engraved area in the resulting display panel is thicker. The degree of increased thickness can be adjusted by changing the depth of the engraved area on the roller. A deeper engraved area on the roller will result in a thicker bottom of the micropores in the corresponding area.

[0049] The term "positive image" mentioned above means that the engraved pattern on the roll is the same as the expected pattern of the display panel. In this case, the display panel formed will have a patterned area in which the micropores have a thicker bottom.

[0050] The term "negative image" mentioned above means that the engraved pattern corresponds to an area excluding the intended pattern of the display panel. In this case, the formed display panel will have a background area in which the micropores have a thicker bottom.

[0051] The surface of the roll is curved. However, it is drawn as a straight line in Figures 4 and 5 for illustration purposes only.

[0052] The increased thickness of the micropores need not be the same, which can be achieved by the described method. In other words, a variation in the depth of the engraved area on the roll will result in a variation in the thickness of the bottom of the micropores.

[0053] Suitable imprintable compositions for forming micropores have been previously disclosed. U.S. Pat. Nos. 6,831,770 and 6,930,818 describe that suitable compositions for forming micropores may include thermoplastic materials, thermosetting materials, or precursors thereof. Examples of thermoplastic or thermosetting precursors may include multifunctional acrylates or methacrylates, multifunctional vinyl ethers, multifunctional epoxides, and oligomers or polymers thereof. Crosslinkable oligomers that impart flexibility, such as urethane acrylates or polyester acrylates, may also be added to improve the flexural resistance of the imprinted micropores.

[0054] U.S. Pat. No. 7,880,958 describes another imprintable composition for micropores, which may include a polar oligomer or polymer material. Such a polar oligomer or polymer material may be selected from oligomers or polymers having at least one group such as nitro (-NO2), hydroxyl (-OH), carboxyl (-COO), alkoxy (-OR, wherein R is an alkyl group), halogen (e.g., fluorine, chlorine, bromine or iodine), cyano (-CN), sulfonate (-SO3), etc. The glass transition temperature of the polar polymer material is preferably below about 100°C, and more preferably below about 60°C. Specific examples of suitable polar oligomeric or polymeric materials may include, but are not limited to, polyhydroxy-functional polyester acrylates (e.g., BDE 1025, Bomar Specialties Co, Winsted, CT) or alkoxylated acrylates, such as ethoxylated nonylphenol acrylate (e.g., SR504, Sartomer), ethoxylated trimethylolpropane triacrylate (e.g., SR9035, Sartomer), or ethoxylated pentaerythritol tetraacrylate (e.g., SR494, from Sartomer).

[0055] U.S. Patent Application No. 13 / 686,778 discloses another type of imprintable composition for forming micropores. The composition comprises (a) at least one bifunctional UV curable component, (b) at least one photoinitiator, and (c) at least one release agent. Suitable bifunctional components may have a molecular weight greater than about 200. Bifunctional acrylates are preferred, and bifunctional acrylates having a urethane or ethoxylated backbone are particularly preferred. More specifically, suitable bifunctional components may include, but are not limited to, diethylene glycol diacrylate (such as SR230 from Sartomer), triethylene glycol diacrylate (such as SR272 from Sartomer), tetraethylene glycol diacrylate (such as SR268 from Sartomer), polyethylene glycol diacrylate (such as SR295, SR344 or SR610 from Sartomer), polyethylene glycol dimethacrylate (such as SR603, SR644, SR252 or SR740 from Sartomer) , ethoxylated bisphenol A diacrylate (such as CD9038, SR349, SR601 or SR602 from Sartomer), ethoxylated bisphenol A dimethacrylate (such as CD540, CD542, SR101, SR150, SR348, SR480 or SR541 from Sartomer) and urethane diacrylate (such as CN959, CN961, CN964, CN965, CN980 or CN981 from Sartomer; Ebecryl 230, Ebecryl 270, Ebecryl 8402, Ebecryl 8804, Ebecryl 8807 or Ebecryl 8808 from Cytec). Suitable photoinitiators may include, but are not limited to, bisacylphosphine oxide, 2-benzyl-2-(dimethylamino)-1-[4-(4-morpholinyl)phenyl]-1-butanone, 2,4,6-trimethylbenzoyldiphenylphosphine oxide, 2-isopropyl-9H-thioxanthen-9-one, 4-benzoyl-4'-methyldiphenyl sulfide and 1-hydroxy-cyclohexyl-phenyl-ketone, 2-hydroxy-2-methyl-1-phenyl-propan-1-one, 1-[4-(2-hydroxyethoxy)-phenyl]-2-hydroxy-2-methyl-1-propane-1-one, 2,2-dimethoxy-1,2-diphenylethan-1-one or 2-methyl-1[4-(methylthio)phenyl]-2-morpholinopropan-1-one.Suitable release agents may include, but are not limited to, organomodified silicone copolymers such as silicone acrylates (e.g., Ebercryl 1360 or Ebercyl 350 from Cytec), silicone polyethers (e.g., Silwet 7200, Silwet 7210, Silwet 7220, Silwet 7230, Silwet 7500, Silwet 7600, or Silwet 7607 from Momentive). The composition may further optionally include one or more of the following components, a co-initiator, a monofunctional UV curable component, a multifunctional UV curable component, or a stabilizer.

[0056] The contents of all patents / patent applications mentioned above are incorporated herein by reference in their entirety.

[0057] Alternatively, you can Figure 6 The display panel of the present invention is prepared as shown. In this case, micropores can be first prepared according to the method of Figures 4A and 4B. After the imprintable composition is hardened and the micropores (60) are formed, the chemical composition (61) is filled into the micropores of a predetermined area (which may correspond to a patterned area or a background area on the display panel). The chemical composition contains a solid material dissolved or dispersed in an easily removable solvent.

[0058] The filling of the chemical composition in the predetermined area may be accomplished by methods such as inkjet printing or screen printing.

[0059] The solid material may be a curable material, such as any of those materials described above for use in the imprint composition. If the solid material is a curable material, there may be an optional curing step after the solvent is removed. Curing may be accomplished by known conventional methods such as thermal curing or radiation curing.

[0060] The solid material may also be a material that does not require curing, such as polyurethane, poly(ethylene oxide), polystyrene, acrylate polymers [such as poly(methyl acrylate) and poly(butyl acrylate)] or methacrylate polymers [such as poly(methyl methacrylate) and poly(ethyl methacrylate)].

[0061] Note that the solid material in the chemical composition does not have to be the same as the imprintable composition used to form the microwells.

[0062] Examples of suitable solvents for this method may include, but are not limited to, methyl ethyl ketone, acetone, or isopropyl alcohol. After the chemical composition (61) is filled into the micropores of the predetermined area, the solvent in the chemical composition is removed by evaporation or boiling.

[0063] Once the solvent is removed, the solid material remaining in the chemical composition should provide good adhesion to the bottom of the microwells and also not interact with the display fluid filling the microwells.

[0064] The thickness increased in the micropores is determined by the solid content in the chemical composition. In other words, the thickness increased in the micropores can be determined by the concentration of the chemical composition. Typically, a concentration of 0.01 wt % to 90 wt %, preferably 0.01 wt % to 50 wt % is suitable.

[0065] The microwells can also be filled with different concentrations of chemical compositions, resulting in different bottom thicknesses.

[0066] In any of the above methods, after the microwells are formed, a display fluid is filled into the microwells. The display fluid may be an electrophoretic fluid, which comprises charged particles dispersed in a solvent or a solvent mixture.

[0067] like Figure 7 As shown, a display panel (70) having a predetermined image is sandwiched between two electrode layers (77 and 78) when filled with an electrophoretic fluid (76).

[0068] Traditionally, electrophoretic fluids may have one type of charged pigment particles dispersed in a solvent or solvent mixture of contrasting colors. In this case, when a voltage potential difference is applied between two electrode plates sandwiching a display panel, the charged particles migrate to a plate with a polarity opposite to that of the particles by attraction. Therefore, the color displayed on a transparent plate may be the color of the solvent or the color of the pigment particles. The reversal of plate polarity will cause the charged particles to migrate back to the opposite plate, thereby reversing the color. Alternatively, the electrophoretic fluid may have two types of charged particles with contrasting colors and opposite charges, and the two types of pigment particles are dispersed in a transparent solvent or solvent mixture. In this case, when a voltage potential difference is applied between two electrode plates sandwiching a display panel, the two types of pigment particles will move to opposite ends (top or bottom). Therefore, one of the colors of the two types of pigment particles will be seen on the observation side. In another alternative, charged particles of other colors are added to the electrophoretic fluid to form a highlight or multicolor display device. All of these options are suitable for the display panel of the present invention.

[0069] Due to the difference in bottom thickness, the charged particles in the microwells in one area will respond differently to the electric field generated between the two electrode layers than the charged particles in the microwells in another area, resulting in different color intensity levels being displayed. Figure 8An example of this phenomenon is shown. The white particles in micropore A (in one area) respond to the electric field generated between electrode layers 87 and 88 and move to the vicinity of electrode 87 or to electrode 87, and as a result, white is seen on the observation side. In micropore B (in another area), since the bottom is thicker, the white particles sense a weaker electric field, and as a result, gray is displayed.

[0070] Since the microwells can have different bottom thicknesses in the area represented by microwell B, different color intensity levels (ie, grayscale) are possible.

[0071] although Figure 8 Only designs with only one type of charged particles are shown, but the phenomena shown are applicable to electrophoretic fluids with any number of types of charged particles.

[0072] In one embodiment of the present invention, both electrode layers are non-patterned conductive layers such as indium tin oxide, copper or aluminum. In this case, when a voltage potential difference is applied across the two electrode layers, the regions where the micropores have a bottom thickness level different from those of the other regions will be displayed in a color state with a different intensity than the other regions. This design is particularly suitable for sign displays with fixed images such as bar codes, anti-counterfeiting labels, direction signs or shelf labels.

[0073] In another embodiment, one of the electrode layers is a common electrode and the other electrode layer is a TFT (thin film transistor) matrix drive system or a segmented backplane drive system. In this case, the entire display panel can be switched from one image to another while one area remains visually distinguishable from another area. This embodiment of the invention is particularly suitable as a watermark, and the watermark does not interfere with the switching of images.

[0074] In another embodiment, the interior surface of the microwells can be treated to alter its chemical functionality, morphology, microstructure, charge characteristics, surface tension, or optical density.

[0075] For example, the surface can be treated with probe molecules or precursors thereof that donate electrons or accept protons, including but not limited to ammonia, amines, imines, pyridine, urea, thiourea, urethane, pyrrolidone, imidazole, ether, thioether, ketone, acrylate and acrylamide. Alternatively, the surface can be treated with probe molecules or precursors thereof that accept electrons or donate protons, including but not limited to oxygen, carboxylic acid compounds, hydroxyl-containing compounds, acrylamide, silanols or organometallic compounds containing electron defect centers.

[0076] Another option for surface treatment involves changing the chemical functionality of the microporous surface by plasma or corona treatment to induce interactions between the charged pigment particles and the surface. A specific example is to modify the surface by plasma treatment using probe molecules with functional groups that can form hydrogen bonds or acid-base reactions with functional groups on the surface of the dispersed particles. Hydrogen bonds can be formed by proton donors or electron acceptors on the microporous surface and proton acceptors or electron donors on the particles, or vice versa.

[0077] Further alternatively, the surface may be modified with a plasma treatment to form a sterically stabilizing or protective colloidal layer on the pore surface.

[0078] All of the above-mentioned surface treatment methods and other options are described in US Pat. No. 6,870,662, the contents of which are incorporated herein by reference in their entirety.

[0079] It should also be noted that the surface treatment of the micropores may be applied to all micropores or only selected micropores, depending on the needs.

[0080] The subject matter proposed in this article can also be used to construct an active molecule delivery system, whereby the active molecule can be released on demand and / or a variety of different active molecules can be delivered from the same system and / or different concentrations of active molecules can be delivered from the same system. This subject matter is very suitable for transdermal delivery of drugs to patients, but the concept proposed in this article can generally be used to deliver active ingredients. For example, this subject matter can deliver sedatives to horses during transportation. The active delivery system includes a plurality of micropores, wherein the micropores are filled with a medium containing active molecules. The micropores include an opening, and the opening is spanned by a porous diffusion layer. The micropore array can be loaded with different active ingredients, thereby providing a mechanism for delivering different or complementary active ingredients on demand.

[0081] In addition to more conventional applications such as transdermal delivery of pharmaceutical compounds, active molecule delivery systems can be the basis for delivering agricultural nutrients. For example, microporous arrays can be made into large sheets that can be used in conjunction with hydroponic growth systems, or microporous arrays can be integrated into hydrogel film agriculture. See, for example, Mebiol, Inc. (Kanagawa, Japan). Active molecule delivery systems can also be incorporated into the structural walls of smart packaging. Such a delivery system makes it possible for antioxidants to be released into packages containing fresh vegetables for a long time. This "smart" packaging will significantly improve the shelf life of certain foods, and until the package is opened, only the amount of antioxidants required to keep fresh is required. Therefore, the same packaging can be used for foods distributed locally, nationwide, or globally.

[0082] The present subject matter may also provide a system for delivering a "cocktail" of active molecules on demand simply and at low cost. Such a delivery system may, for example, be used as an emergency delivery system for people experiencing allergic reactions. The system may include epinephrine as well as an antihistamine. The device may be applied and then triggered to rapidly pass the actives through the skin. The system may be particularly effective as a backup system for small children who may be exposed to life-threatening allergens during field trips, etc. A parent may attach the delivery system to the child with instructions to activate the device in the event of, for example, a bee sting. Because the device is relatively simple, compliance with appropriate delivery protocols will be greater than, for example, an epipen.

[0083] Fig.10 1 shows an overview of an active molecule delivery system. The system includes a plurality of microwells 110, each of which may have a different bottom thickness and may include a medium (also referred to as an internal phase) containing active molecules 120a / b / c. Fig.10 As shown, the first micropore may contain a first active substance 120a, while the second micropore may contain a second active substance 120b, and the third micropore contains a third active substance 120c. Each micropore 110 is part of an array formed by a polymer matrix, which will be described in more detail below. The active molecule delivery system will generally include a backing barrier 130 to provide structural support and prevent moisture from entering and physically interacting. The micropores are defined by walls 140 that are at least 1 μm high, although they can be much higher depending on the desired depth of the micropores. The micropores can be arranged in squares, honeycombs, circles, etc. The microwells 110 will have openings spanned by a porous diffusion layer 150, which can be composed of a variety of natural or non-natural polymers such as acrylates, methacrylates, polycarbonates, polyvinyl alcohol, cellulose, poly(N-isopropylacrylamide) (PNIPAAm), poly(lactic-co-glycolic acid) (PLGA), polyvinylidene chloride, acrylonitrile, amorphous nylon, oriented polyester, terephthalate, polyvinyl chloride, polyethylene, polypropylene, polybutylene, polyisobutylene or polystyrene. Often, the system will additionally include an adhesive layer 160 that is also porous to the active molecule. The adhesive layer 160 helps to keep the active molecule delivery system adjacent to the surface. Using picoliter injection with an inkjet or other fluid system, a single microwell can be filled to allow a variety of different actives to be included in the active molecule delivery system.

[0084] Also like Fig.10 As shown, the depth of different microwells 127, 128, 129 is changed by increasing the amount of polymer at the bottom of the microwell. This is easily achieved by using a mold with the desired depth and the embossing technique described below. In other embodiments, the width of the microwell can be larger or smaller, depending on the volume of the solution including the active substance desired to be contained in a given microwell.

[0085] Although the present invention has been described with reference to specific embodiments of the present invention, it will be appreciated by those skilled in the art that various changes may be made and may be replaced by equivalents without departing from the true spirit and scope of the present invention. In addition, many modifications may be made to adapt specific circumstances, materials, compositions, processes, processing steps or steps to the purpose, spirit and scope of the present invention. All of these modifications are intended to fall within the scope of the appended claims herein.

Claims

1. An active molecule delivery system comprising a plurality of micropores, wherein: The plurality of micropores are filled with a medium containing active molecules, the plurality of micropores include openings, and the openings are spanned by a porous diffusion layer, wherein each micropore has a bottom, the delivery system has a first region and a second region, the micropores in the first region have substantially the same bottom thickness, and the micropores in the second region have a thicker bottom than the micropores in the first region.

2. The active molecule delivery system according to claim 1, wherein The bottom thickness of the micropores in the second region is 0.001 μm to 9 / 10 of the depth of the micropores in the first region, which is greater than the bottom thickness of the micropores in the first region.

3. The active molecule delivery system according to claim 1, wherein The bottom thickness of the micropores in the second region is from 0.001 μm to 1 / 2 of the depth of the micropores in the first region, which is greater than the bottom thickness of the micropores in the first region.

4. The active molecule delivery system according to claim 1, wherein The bottom thickness of the microwells in the second region is different.

5. A method for preparing the active molecule delivery system of claim 1, comprising: a) providing a roller having an engraved area on its surface to form a pattern, the pattern being a positive image or a negative image of a desired pattern for a display panel, wherein the engraved area has different depths; b) applying an embossable composition to the substrate layer on the surface of the roller; and c) Applying a positive mold on the embossable composition.

6. A method for preparing the active molecule delivery system of claim 1, comprising: a) providing micropores; b) filling the micropores in the predetermined area with a chemical composition in a solvent; c) removing the solvent; and d) optionally curing the chemical composition after removing the solvent.

7. The method of claim 6, wherein: The solvent is methyl ethyl ketone, acetone or isopropyl alcohol.

8. The method of claim 6, wherein: The microwells are filled with chemical compositions at different concentrations.

9. The method of claim 8, wherein: The concentration is 0.01 wt % to 90 wt %.

10. The method of claim 8, wherein: The concentration is 0.01 wt % to 50 wt %.

11. The method of claim 6, wherein: The chemical composition is different from the composition forming the micropores.

12. The method of claim 6, wherein: The chemical composition is the same as the composition forming the micropores.

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