Synthesis method for preparing 5-bromine-2-chloro-4'-ethyoxyl diphenylmethane

By using o-chlorobenzoic acid as the starting material and adopting acyl chlorination, Friedel-Crafts acylation and bromination reactions, the problems of using highly toxic compounds and high costs in the existing technology were solved, and high-purity and environmentally friendly 5-bromo-bromo was achieved. -Preparation of 2-chloro-4'-ethoxydiphenylmethane, suitable for industrial production.

CN114044739AActive Publication Date: 2022-02-15SUZHOU KAIYUAN MINSHENG SCI & TECH CORP
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Patent Information

Application Number
CN202210030161.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2022-01-12
Publication Date
2022-02-15
Estimated Expiration
2042-01-12

AI Technical Summary

Technical Problem

The existing preparation method of 5-bromo-2-chloro-4'-ethoxydiphenylmethane has the problems of using highly toxic compounds, high raw material costs, low yields and environmental pollution, and the existing technical routes are complex and have many auxiliary materials. , it is difficult to meet the needs of industrial production.

Method used

Using o-chlorobenzoic acid as the starting material, through acyl chlorination, Friedel-Crafts acylation, bromination and reduction reactions, using low-toxic solvents and common compounds, and recycling the solvent, 5-bromo-2-chloro-4'- Ethoxydiphenylmethane has a streamlined route and high purity, and is suitable for industrial production.

Benefits of technology

The preparation of high-purity (more than 99.3%) 5-bromo-2-chloro-4'-ethoxydiphenylmethane is achieved, which reduces production costs, avoids environmental pollution, is suitable for industrial production, and does not require high equipment.

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Abstract

The invention relates to a synthesis method for preparing 5-bromine-2-chloro-4'-ethyoxyl diphenylmethane, which comprises the following steps of chloridizing o-chlorobenzoic acid to prepare o-chlorobenzoyl chloride, performing Friedel-Crafts acylation to prepare 2-chloro-4'-iodobenzophenone, further brominating to prepare 5-bromine-2-chloro-4 '-iodobenzophenone, reducing to prepare the 5-bromine-2-chloro-4'-iodobenzophenone, and reacting the 5-bromine-2-chloro-4'-ethyoxyl diphenylmethane to prepare the 5-bromine-2-chloro-4'-ethyoxyl diphenylmethane, and finally, carrying out a substitution reaction to prepare the 5-bromo-2-chloro-4'-ethyoxyl diphenylmethane. The method is simple in route, the obtained product is high in purity, the used raw materials and auxiliary materials are common compounds, a low-toxicity solvent is adopted and can be recycled, phosphorus-containing wastewater is not generated, and the method is high in safety, environmentally friendly, low in cost, low in equipment requirement and suitable for industrial production.
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