A composite nerve conduit and a method of making the same
By preparing a multi-layered neural conduit scaffold, combined with mineralized collagen fibers and active elements, the shortcomings of existing neural conduits in promoting blood cell migration and nerve growth have been overcome. This has improved the biocompatibility and physical support of the conduit, and promoted nerve and blood vessel regeneration.
CN114081999BActive Publication Date: 2026-07-03TSINGHUA UNIVERSITY
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- TSINGHUA UNIVERSITY
- Filing Date
- 2021-11-16
- Publication Date
- 2026-07-03
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Figure CN114081999B_ABST
Abstract
This application discloses a nerve conduit, comprising: mineralized collagen nanofibers doped with active elements; the mineralized collagen nanofibers containing hydroxyapatite crystals; the calcium element in the hydroxyapatite crystal lattice being replaced by a cation containing the active element, and / or, the phosphate group in the hydroxyapatite crystal lattice being replaced by anion containing the active element; the nerve conduit provided by this application, by introducing dopant elements, allows the cations or anions of the dopant elements to be effectively and controllably released from the phosphorus or calcium in the hydroxyapatite lattice of the mineralized collagen nanofibers, thereby effectively promoting the regeneration of human tissues such as nerves and blood vessels compared to nerve conduits without dopant elements.
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