A low temperature cooling pharmaceutical reaction kettle

Abstract

The invention discloses a low-temperature cooling pharmaceutical reaction kettle, comprising a reaction ball and a stirring mechanism, characterized in that: the reaction ball comprises an inner ball and an outer ball, an intermediate chamber is formed between the outer ball and the inner ball, a feed pipe is slidably provided on the top of the outer ball, a discharge pipe is slidably provided on the bottom of the outer ball, a notch is provided on the inner ball, the feed pipe, the discharge pipe and the notch are in the same straight line, a rotating column is extended outward on the left and right side walls of the inner ball, the rotating column is rotatably provided on the outer ball, the stirring mechanism is provided in the inner ball, a rotating shaft extends out of the outer ball and is connected to a driving motor, a first bevel gear is provided on the outer end of the rotating shaft for transmission, a second bevel gear is fixedly provided on the outer end surface of the rotating column, the rotating shaft passes through the hollow second bevel gear, and an intermediate bevel gear is meshed and transmitted between the first bevel gear and the second bevel gear. The invention provides a low-temperature cooling pharmaceutical reaction kettle, which improves the efficiency and uniformity of cooling of drug intermediates.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceuticals, in particular to a low-temperature cooling pharmaceutical reaction kettle. Background Art

[0002] Every year, my country needs a variety of raw materials and intermediates that are compatible with the chemical industry, with a demand of more than 10,000 tons; the so-called pharmaceutical intermediates are actually some chemical raw materials or chemical products used in the process of drug synthesis. This kind of chemical product does not require a drug production license and can be produced in an ordinary chemical plant. As long as it reaches a certain level, it can be used in the synthesis of drugs. The pharmaceutical intermediate industry is a branch of the chemical industry. After years of development, it has become an emerging industry with an output value of tens of billions of yuan, and its competition has become more intense. In the early stages of the industry's development, due to small investments and high returns, pharmaceutical intermediate companies have sprung up like mushrooms after rain.

[0003] Most of the drug intermediates of western medicine are obtained through organic synthesis. Many organic syntheses are basically completed in reactors. However, the existing reactors are basically placed in a static state for reaction. The reaction time of the reactor in a static state is long. Due to insufficient stirring, it is easy to cause incomplete reaction, poor reaction effect, and low work efficiency. In addition, the drug intermediates will release a lot of heat during the reaction in the reactor. If the temperature is too high, the pharmaceutical intermediates will deteriorate and affect their use.

[0004] To this end, the existing Chinese utility model patent with publication number CN206315796U discloses "A low-temperature cooling pharmaceutical reactor", including a bottom plate, two support plates are symmetrically installed on the upper end surface of the bottom plate, each support plate is welded with a support ring, a rotating shaft is installed in the middle of each support ring through a bearing, and a reaction ball is welded between the two rotating shafts on the two support plates, a pharmaceutical intermediate to be reacted is placed in the reaction ball, a rotating motor is installed on the rotating shaft located on the left side of the reaction ball through a coupling, the rotating motor is installed on an L-shaped bracket through a motor seat, and the L-shaped bracket is welded to the support plate located on the left side of the reaction ball; four inner cold boxes are symmetrically installed at the upper and lower ends of the inner wall of the reaction ball; two outer cold boxes are symmetrically installed on the left and right sides of the outer wall of the reaction ball. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide a low-temperature cooling pharmaceutical reaction kettle in view of the current status of the prior art, so as to improve the efficiency and uniformity of cooling of drug intermediates.

[0006] The technical solution adopted by the present invention to solve the above technical problems is: a low-temperature cooling pharmaceutical reactor, including a reaction ball and a stirring mechanism, the stirring mechanism including a rotating shaft and a stirring blade arranged on the rotating shaft, characterized in that: the reaction ball includes an inner ball and an outer ball, an intermediate chamber is formed between the outer ball and the inner ball, a feed pipe is slidably arranged on the top of the outer ball, a discharge pipe is slidably arranged on the bottom of the outer ball, a notch is arranged on the inner ball, the feed pipe, the discharge pipe and the notch are in the same straight line, a sealing plate is slidably arranged at the notch, the sealing plate is connected to a sealing drive member, and a feed pipe is arranged on the outer ball. The liquid port and the liquid outlet, the liquid inlet and the liquid outlet are connected to an external water tank through a pipeline, a water pump and a refrigerator are arranged in the water tank, a heat-conducting stirring plate is arranged on the outer wall of the inner ball, a rotating column is extended outward from the left and right side walls of the inner ball, the rotating column is rotatably arranged on the outer ball, the stirring mechanism is arranged in the inner ball, the rotating shaft extends outward from the outer ball and is connected to a driving motor, a first bevel gear is arranged on the outer end of the rotating shaft for transmission, a second bevel gear is fixedly arranged on the outer end surface of the rotating column, the rotating shaft passes through the hollow second bevel gear, and an intermediate bevel gear is meshed and transmitted between the first bevel gear and the second bevel gear.

[0007] As an improvement, a cooling channel is provided in the heat-conducting stirring plate, and multiple layers of U-shaped channels are provided in the side wall of the inner sphere, and the cooling channel is connected to one layer of the U-shaped channels.

[0008] As a further improvement, an upper locking sleeve is provided below the feed pipe, an upper flexible connecting tube is connected between the upper locking sleeve and the feed pipe, an upper connecting spring is provided on the outer sleeve of the upper flexible connecting tube, the upper end of the upper connecting spring is connected to the lower end of the feed pipe, the lower end of the upper connecting spring is connected to the upper locking sleeve, an upper permanent magnet is provided in the upper locking sleeve, and an electromagnet is provided at the notch of the inner ball.

[0009] As a further improvement, a lower locking sleeve is provided above the discharge pipe, a lower flexible connecting pipe is connected between the lower locking sleeve and the discharge pipe, a lower connecting spring is provided on the outer sleeve of the lower flexible connecting pipe, the lower end of the lower connecting spring is connected to the upper end of the discharge pipe, the upper end of the lower connecting spring is connected to the lower locking sleeve, a lower permanent magnet is provided in the lower locking sleeve, and an electromagnet is provided at the notch of the inner ball.

[0010] Compared with the prior art, the advantages of the present invention are: the present invention designs the traditional reaction ball into an inner and outer ball structure, circulates cooling water into the middle chamber, so that the cooling water is in direct contact with the outer wall of the inner ball. At the same time, the inner ball is designed to rotate, and the heat-conducting stirring plate stirs the cooling water in the middle chamber. The rotation direction of the stirring mechanism inside the inner ball is opposite to the rotation direction of the inner ball, thereby improving the efficiency and uniformity of cooling the drug intermediate in the inner ball. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] Figure 1 Schematic diagram of the structure of a low-temperature cooling pharmaceutical reaction kettle in an embodiment of the present invention;

[0012] Figure 2 Schematic diagram of the connection structure of the feed pipe in an embodiment of the present invention;

[0013] Figure 3 Schematic diagram of the connection structure of the discharge pipe in the embodiment of the present invention;

[0014] Figure 4 Schematic diagram of the connection structure between the heat-conducting stirring plate and the inner ball in an embodiment of the present invention. DETAILED DESCRIPTION

[0015] The present invention is further described in detail below with reference to the accompanying drawings.

[0016] like Figures 1 to 4 As shown, the low-temperature cooling pharmaceutical reaction kettle in this embodiment includes a reaction ball, a stirring mechanism 5, a water tank 3, a water pump 31, a refrigerator 32, a first bevel gear 61, a second bevel gear 62, an intermediate bevel gear 63 and a driving motor 4.

[0017] Among them, the stirring mechanism 5 includes a rotating shaft 51 and a stirring blade 52 arranged on the rotating shaft 51, the reaction ball includes an inner ball 1 and an outer ball 2, an intermediate chamber 10 is formed between the outer ball 2 and the inner ball 1, a feed pipe 21 is slidably arranged on the top of the outer ball 2, and a discharge pipe 22 is slidably arranged on the bottom of the outer ball 2, and electromagnetic valves are respectively arranged in the feed pipe 21 and the discharge pipe 22 to prevent the inflow of cooling water, a notch 12 is arranged on the inner ball 1, the feed pipe 21, the discharge pipe 22 and the notch 12 are on the same straight line, a sealing plate 13 is slidably arranged at the notch 12, and the sealing plate 13 is connected to a sealing drive member, a liquid inlet 23 and a liquid outlet 24 are arranged on the outer ball 2, and the liquid inlet 23 and the liquid outlet 24 are connected to the external water tank 3 through a pipeline, and a water pump 31 and a refrigerator 32 are arranged in the water tank 3, a heat-conducting stirring plate 11 is arranged on the outer wall of the inner ball 1, and a rotating column 14 extends outward from the left and right side walls of the inner ball 1, and a rotating column 14 is arranged on the left and right side walls of the inner ball 1. The column 14 is rotatably arranged on the outer ball 2, the stirring mechanism 5 is arranged in the inner ball 1, the rotating shaft 51 extends out of the outer ball 2 and is connected to a driving motor 4, a first bevel gear 61 is transmission-arranged on the outer end of the rotating shaft 51, a second bevel gear 62 is fixedly arranged on the outer end surface of the rotating column 14, the rotating shaft 51 passes through the hollow second bevel gear 62, and an intermediate bevel gear 63 is meshed and transmitted between the first bevel gear 61 and the second bevel gear 62. In this way, in the process of the driving motor 4 driving the stirring blade 52 to rotate through the rotating shaft 51, the first bevel gear 61 rotates synchronously with the rotating shaft 51, and after the first bevel gear 61 is acted upon by the intermediate bevel gear 63, the rotation direction of the second bevel gear 62 is exactly opposite to that of the first bevel gear 61, and the second bevel gear 62 is connected to the rotating column 14 of the inner ball 1, so that the second bevel gear 62 can drive the inner ball 1 to rotate synchronously, and at the same time, the rotation directions of the inner ball 1 and the stirring blade 52 are just opposite.

[0018] Furthermore, if Figure 4 As shown, in order to improve the heat dissipation capacity of the inner ball 1, a cooling channel 111 is opened in the heat-conducting stirring plate 11, and a plurality of U-shaped channels 101 are opened in the side wall of the inner ball 1, and the cooling channel 111 is connected to one of the U-shaped channels 101. During the rotation of the inner ball 1, the heat-conducting stirring plate 11 stirs the cooling water, and the flow of the cooling water acts vertically on the side wall of the heat-conducting stirring plate 11. Part of the cooling water enters the inside of the heat-conducting stirring plate 11 from the cooling channel 111 of the heat-conducting stirring plate 11, and flows from the heat-conducting stirring plate 11 to one of the U-shaped channels 101 of the inner ball, and finally flows out from the outer end of the U-shaped channel 101. The cooling water flowing out of the U-shaped channel 101 acts on the outer side wall of the adjacent heat-conducting stirring plate 11 again; at the same time, most of the cooling water will flow along the side wall of the heat-conducting stirring plate 11 to the outer wall of the inner ball, and flow to When the heat conducting stirring plate 11 reaches the root of the heat conducting stirring plate 11, some cooling water enters the U-shaped channel 101, and then the cooling water coming out of the U-shaped channel 101 also acts on the outer wall of the adjacent heat conducting stirring plate 11, thereby forming a cooling water reflux water circulation, which greatly improves the cooling capacity of the heat conducting stirring plate 11 and the inner ball 1. In this process, in addition to bringing the heat of the inner ball 1 to the heat conducting stirring plate 11 to increase the diffusion of heat, the heat conducting stirring plate 11 can also stir the cooling water as the inner ball 1 rotates, so that the cooling water keeps flowing.

[0019] Furthermore, if Figure 2 As shown, an upper locking sleeve 213 is provided below the feed pipe 21, an upper flexible connecting tube 211 is connected between the upper locking sleeve 213 and the feed pipe 21, an upper connecting spring 212 is provided on the outer sleeve of the upper flexible connecting tube 211, the upper end of the upper connecting spring 212 is connected to the lower end of the feed pipe 21, the lower end of the upper connecting spring 212 is connected to the upper locking sleeve 213, an upper permanent magnet 214 is provided in the upper locking sleeve 213, and an electromagnet 131 is provided at the notch 12 of the inner ball 1. When adding reactants to the inner ball 1, the feed tube 21 extends toward the inner ball, the locking sleeve 213 abuts against the outer wall of the inner ball 1, and the electromagnet 131 at the notch 12 of the inner ball 1 is energized. As the inner ball 1 rotates, when the notch 12 of the inner ball 1 rotates to the position of the locking sleeve 213, the upper locking sleeve 213 is inserted into the notch 12 under the mutual attraction of the upper permanent magnet 214 and the electromagnet 131. At this time, the sealing drive opens the sealing plate 13, and the feed tube 21 is connected to the inner cavity of the inner ball 1, so that the reactants can be added to the inner ball 1. After the addition is completed, the sealing plate 13 is closed, the electromagnet 131 loses power, and the feed tube 21 is retracted, thereby realizing feeding into the inner ball 1.

[0020] Likewise, if Figure 3As shown, a lower locking sleeve 223 is arranged above the discharge pipe 22, a lower flexible connecting pipe 221 is connected between the lower locking sleeve 223 and the discharge pipe 22, a lower connecting spring 222 is arranged on the outer sleeve of the lower flexible connecting pipe 221, the lower end of the lower connecting spring 222 is connected to the upper end of the discharge pipe 22, the upper end of the lower connecting spring 222 is connected to the lower locking sleeve 223, a lower permanent magnet 224 is arranged in the lower locking sleeve 223, and an electromagnet 131 is arranged at the notch 12 of the inner ball 1. When the drug preparation is completed and the reaction product in the inner ball 1 needs to be discharged, the cooling water in the outer ball 2 is discharged first, and the discharge pipe 22 is extended toward the inner ball 1, and the lower locking sleeve 223 is pressed against the outer wall of the inner ball 1, and the electromagnet 131 at the notch 12 of the inner ball 1 is energized. As the inner ball 1 rotates, when the notch 12 of the inner ball 1 rotates to the position of the lower locking sleeve 223, under the mutual attraction of the lower permanent magnet 224 and the electromagnet 131, the lower locking sleeve 223 is stuck in the notch 12. At this time, the sealing drive component opens the sealing plate 13, and the discharge pipe 22 is connected to the inner cavity of the inner ball 1, and the reaction product can be discharged from the discharge pipe 22. After the discharge is completed, the sealing plate 13 is closed, the electromagnet 131 loses power, and the discharge pipe 22 retracts, thereby realizing the discharge from the inner ball 1.

[0021] In summary, the present invention designs the traditional reaction ball into a double-sphere structure of an inner ball 1 and an outer ball 2, and circulates cooling water into the middle chamber 10, so that the cooling water is in direct contact with the outer wall of the inner ball 1. At the same time, the inner ball 1 is designed to rotate, and the heat-conducting stirring plate 11 stirs the cooling water in the middle chamber 10. The rotation direction of the stirring mechanism 5 inside the inner ball 1 is opposite to that of the inner ball 1, thereby improving the efficiency and uniformity of cooling the drug intermediate in the inner ball 1.

Claims

1. A low temperature cooling pharmaceutical reaction kettle, comprising a reaction ball and a stirring mechanism (5), wherein the stirring mechanism (5) comprises a rotating shaft (51) and a stirring blade (52) arranged on the rotating shaft (51), characterized in that: The reaction ball comprises an inner ball (1) and an outer ball (2), an intermediate chamber (10) is formed between the outer ball (2) and the inner ball (1), a feed pipe (21) is slidably provided on the top of the outer ball (2), a discharge pipe (22) is slidably provided on the bottom of the outer ball (2), a notch (12) is provided on the inner ball (1), the feed pipe (21), the discharge pipe (22) and the notch (12) are on the same straight line, a sealing plate (13) is slidably provided at the notch (12), the sealing plate (13) is connected to a sealing driving member, a liquid inlet (23) and a liquid outlet (24) are provided on the outer ball (2), the liquid inlet (23) and the liquid outlet (24) are connected to an external water tank (3) through a pipeline, and a liquid inlet (23) and a liquid outlet (24) are provided in the water tank (3). A water pump (31) and a refrigerator (32); a heat-conducting stirring plate (11) is arranged on the outer wall of the inner ball (1); a rotating column (14) extends outward from the left and right side walls of the inner ball (1); the rotating column (14) is rotatably arranged on the outer ball (2); a stirring mechanism (5) is arranged in the inner ball (1); a rotating shaft (51) extends out of the outer ball (2) and is connected to a driving motor (4); a first bevel gear (61) is arranged on the outer end of the rotating shaft (51) for transmission; a second bevel gear (62) is fixedly arranged on the outer end surface of the rotating column (14); the rotating shaft (51) passes through the hollow second bevel gear (62); an intermediate bevel gear (63) is meshed and transmitted between the first bevel gear (61) and the second bevel gear (62); The heat-conducting stirring plate (11) is provided with a cooling channel (111), and the side wall of the inner ball (1) is provided with multiple layers of U-shaped channels (101), wherein the cooling channel (111) is connected to one layer of the U-shaped channels (101); An upper locking sleeve (213) is provided below the feed pipe (21), an upper flexible connecting pipe (211) is connected between the upper locking sleeve (213) and the feed pipe (21), an upper connecting spring (212) is provided on the outer sleeve of the upper flexible connecting pipe (211), the upper end of the upper connecting spring (212) is connected to the lower end of the feed pipe (21), the lower end of the upper connecting spring (212) is connected to the upper locking sleeve (213), an upper permanent magnet (214) is provided in the upper locking sleeve (213), and an electromagnet (131) is provided at the notch (12) of the inner ball (1); A lower locking sleeve (223) is arranged above the discharge pipe (22), a lower flexible connecting pipe (221) is connected between the lower locking sleeve (223) and the discharge pipe (22), a lower connecting spring (222) is arranged on the outer sleeve of the lower flexible connecting pipe (221), the lower end of the lower connecting spring (222) is connected to the upper end of the discharge pipe (22), the upper end of the lower connecting spring (222) is connected to the lower locking sleeve (223), a lower permanent magnet (224) is arranged in the lower locking sleeve (223), and an electromagnet (131) is arranged at the notch (12) of the inner ball (1).

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