Automatic analysis device and control program product for automatic analysis device

Abstract

An object of the present application is to provide an automatic analyzer and a control program capable of reducing the total analysis time. The automatic analyzer includes a sample rack that accommodates a sample; a sample dispensing mechanism that aspirates the sample from the sample rack and dispenses it into a reaction vessel; a plurality of detection sections that detect a reaction solution of the reaction vessel; and a control section that controls the sample dispensing mechanism and the detection sections. The control section is configured to confirm a measurement item designated for the sample, and confirm one of the plurality of detection sections designated in the measurement item. In a case where measurement of the same detection section among the plurality of detection sections is continuously designated, the dispensing order of the sample dispensing mechanism is switched so that measurement of a different detection section is continuously designated.

Description

Technical Field

[0001] This invention relates to an automatic analysis device and its control program. Background Technology

[0002] Automated analysis devices typically include a sample dispensing mechanism for dispensing samples and a detection unit for reacting the dispensed samples with reagents in a reaction vessel for testing. Furthermore, multiple detection units are provided in a single device, and testing is performed in the corresponding detection unit according to the test item (see, for example, Patent Document 1). Multiple detection units operate in parallel, thereby shortening the analysis time.

[0003] In such automated analysis devices, sometimes a test item is specified for each supplied sample, and one of multiple testing sections is specified for each test item. The automated analysis device assigns the specified testing section and performs the test sequentially.

[0004] However, in multiple consecutive measurement projects, the same detection unit is sometimes specified continuously. In this case, using only one of the multiple detection units continuously without using the others results in a situation where multiple detection units cannot operate in parallel. As a result, the total analysis time may increase.

[0005] Existing technical documents

[0006] Patent documents

[0007] Patent Document 1: Japanese Patent Application Publication No. 2011-185821 Summary of the Invention

[0008] The problem that the invention aims to solve

[0009] The purpose of this invention is to provide an automatic analysis device and control program that can shorten the total analysis time.

[0010] Solution for solving the problem

[0011] To achieve the above objectives, the automatic analysis apparatus of the present invention includes: a specimen holder for receiving specimens; a specimen dispensing mechanism for drawing the specimens from the specimen holder and dispensing them into a reaction vessel; a plurality of detection units for detecting the reaction liquid in the reaction vessel; and a control unit for controlling the specimen dispensing mechanism and the detection units. The control unit is configured to confirm a specified measurement item for the specimen and to confirm one of the plurality of detection units specified in the measurement item. If measurements of the same detection unit among the plurality of detection units are specified consecutively, the control unit rearranges the dispensing order of the specimen dispensing mechanism to ensure that measurements of different specified detection units are continuous.

[0012] Invention Effects

[0013] According to the present invention, even when a detection unit is specified for each item, by sorting the sample dispensing, the total analysis time can be shortened by performing measurements sequentially through alternating detection units as much as possible. Attached Figure Description

[0014] Figure 1 This is a schematic diagram illustrating the general outline of the analytical operations performed in the immunoassay apparatus 101 of the first embodiment.

[0015] Figure 2 This is an explanatory diagram illustrating the problem when the same detection unit is continuously specified in a series of measurement items.

[0016] Figure 3 This is a schematic diagram illustrating the operation of the immunoassay apparatus 101 according to the first embodiment.

[0017] Figure 4 This is a flowchart illustrating the operation of the immunoassay apparatus 101 according to the first embodiment.

[0018] Figure 5 This is a schematic diagram illustrating part of the structure of the automated analysis device (immunoassay device) according to the second embodiment.

[0019] Figure 6 This is a flowchart illustrating the operation of the immunoassay apparatus 101 according to the second embodiment.

[0020] Figure 7 This is a schematic diagram illustrating part of the structure of the automated analysis device (immunoassay device) according to the third embodiment.

[0021] Figure 8A This is a flowchart illustrating the operation of the immunoassay apparatus 101 according to the third embodiment.

[0022] Figure 8B This is a flowchart illustrating the operation of the immunoassay apparatus 101 according to the third embodiment.

[0023] Figure 9 This is a schematic diagram illustrating part of the structure of the automatic analysis device (immunoassay device) according to the fourth embodiment.

[0024] Figure 10 This is a schematic diagram illustrating part of the structure of the automated analysis device (immunoassay device) of the first modified example.

[0025] Figure 11 This is a schematic diagram illustrating part of the structure of the automated analysis device (immunoassay device) of the second modified example.

[0026] Figure 12This is an example of a screen displaying changes to the testing department specified for the recommended testing items. Detailed Implementation

[0027] Hereinafter, this embodiment will be described with reference to the accompanying drawings. In the drawings, functionally identical elements are sometimes indicated by the same or corresponding numbers. Furthermore, the drawings illustrate embodiments and installation examples that follow the principles of this disclosure, but these are for understanding the embodiments and installation examples of this disclosure and are in no way intended to limit the interpretation of this disclosure. The description in this specification is merely typical illustration and does not limit the scope of patent protection or application of this disclosure in any sense.

[0028] In this embodiment, the disclosure has been described in sufficient detail to enable those skilled in the art to implement it. However, it should be understood that other installations and methods are possible, and structural and constructional changes and substitutions of various elements can be made without departing from the scope and spirit of the technical concept of this disclosure. Therefore, the following description should not be interpreted as limited to this.

[0029] [First Implementation]

[0030] Figure 1 This is a schematic structural diagram of the automated analysis apparatus according to the first embodiment. Furthermore, the automated analysis apparatus will be described using an example of its application in an immunoassay apparatus.

[0031] like Figure 1 As shown, the immunoassay analyzer 101 includes a control unit 102, a specimen rack 103, a rack transfer line 104, a specimen dispensing mechanism 105, an incubator (container placement unit) 106, a reaction container transfer mechanism 107, a reaction container holding unit 108, a reaction container stirring mechanism 109, and a waste port 110. In addition, the immunoassay analyzer 101 also includes a reagent tray 111, a reagent dispensing mechanism 112, a B / F separation transfer mechanism 113, a B / F separation mechanism 114, a B / F separation reaction solution aspiration mechanism 115, a buffer solution discharge mechanism 116, a B / F separation post-separation stirring mechanism 117, a detection reaction solution aspiration mechanism 118, and multiple detection units 119 (here, two units: a first detection unit 119A and a second detection unit 119B).

[0032] The control unit 102 is responsible for the overall control of the immunoassay apparatus 101, including the sample dispensing mechanism 105. Details regarding the control will be explained later. Sample containers 120 for holding samples are mounted on a sample rack 103. A single sample rack 103 can be configured to hold multiple sample containers 120. A conveyor line 104 moves the sample containers 120 mounted on the sample rack 103 to the sample dispensing position near the sample dispensing mechanism 105. The control unit 102 includes an operation unit 133 for receiving various operations from the operator, a display unit 134 for displaying interface screens and measurement results, and a storage unit 135 for storing various data and control programs (programs for controlling sample dispensing, analysis, etc.).

[0033] The sample dispensing mechanism 105 is equipped with a nozzle capable of rotation and vertical movement. After drawing in the sample held in the sample container 120, it discharges the drawn-in sample into the reaction container 121 on the incubator 106. The incubator 106 is configured to maintain multiple reaction containers 121 in a heated state and has a reaction plate that promotes the reaction of the reaction solution contained in the reaction containers 121. The reaction plate is configured to rotate about a rotation axis. By rotating the reaction plate, the reaction containers 121 can be moved to the following positions: reaction container setting position L1, reagent discharge position L2, sample discharge position L3, detection reaction solution aspiration position L4, reaction container disposal position L5, and B / F separation and conveying position L6.

[0034] The reaction vessel transport mechanism 107 is a three-axis transport mechanism capable of moving in the X, Y, and Z axes, carrying the sample dispensing tip 128 and the reaction vessel 121 to a predetermined position. The reaction vessel holding part 108 is a holding part for holding multiple unused reaction vessels 121 and sample dispensing tips 128. The reaction vessel stirring mechanism 109 is a stirring mechanism that mixes the sample and reagents in the reaction vessel 121 by applying rotational motion to the reaction vessel 121. The waste port 110 is a hole connected to a waste container (not shown) for disposing of used reaction vessels 121 and sample dispensing tips 128. The reaction vessel transport mechanism 107 moves between the reaction vessel holding part 108, the reaction vessel stirring mechanism 109, the waste port 110, the installation position L7 of the sample dispensing tip 128, and the incubator 106 to transport the sample dispensing tip 128 and the reaction vessel 121.

[0035] A reagent tray 111 is provided with a plurality of reagent containers 136 for holding reagents. The interior of the reagent tray 111 is maintained at a predetermined temperature, and a cover 130 is provided on the upper part of the reagent tray 111. A cover opening 131 is provided on a part of the cover 130.

[0036] The reagent dispensing mechanism 112 has a nozzle configured to rotate and move vertically, and is configured to draw reagent from the reagent container 136 held in the reagent tray 111, and discharge the drawn reagent to the reaction container 121 on the incubator 106. The B / F separation and conveying mechanism 113 moves the reaction container 121, which has been on the incubator 106 for a predetermined time, from the B / F separation and conveying position L6 to the B / F separation mechanism 114. The B / F separation mechanism 114 separates the reaction liquid without magnetic particles and the magnetic particles by adsorbing magnetic particles onto the inner wall of the reaction container 121, wherein the magnetic particles include substances that have immunobinded to the analyte present in the reaction liquid contained in the reaction container 121.

[0037] The reaction liquid aspiration mechanism 115 for B / F separation is configured to move in the X and Z directions. The reaction liquid aspiration mechanism 115 moves above / down above the reaction container 121 after a predetermined time on the B / F separation mechanism 114, aspirating the reaction liquid without magnetic particles in the reaction container 121.

[0038] The buffer discharge mechanism 116 is configured to move in the X and Z axes, and moves above and descends above the reaction vessel 121 after the reaction liquid without magnetic particles is attracted by the B / F separation mechanism 114, discharging the buffer solution into the reaction vessel 121. The stirring mechanism 117 after B / F separation applies rotational motion to the reaction vessel 121, mixing the magnetic particles and buffer solution within the reaction vessel 121. The mixed reaction vessel 121 is then transported to the B / F separation and transport position L6 of the incubator 106 via the B / F separation and transport mechanism 113.

[0039] The reaction solution aspiration mechanism 118 is configured to rotate and move vertically, and is configured to aspirate the reaction solution contained in the reaction container 121 on the incubator 106 and deliver it to the detection unit 119. To shorten the measurement time, the detection unit (analysis unit) 119 is provided with multiple detection units 119 (here, the first detection unit 119A and the second detection unit 119B), which detect (analyze) the concentration of the target analyte in the reaction solution aspirated and delivered by the reaction solution aspiration mechanism 118. The first detection unit 119A and the second detection unit 119B are connected to the reaction solution aspiration mechanism 118 via a liquid delivery path 132.

[0040] Next, an overview of the analysis operations performed in the immunoassay apparatus 101 of the first embodiment will be described.

[0041] During the analysis process, the control unit 102 first receives the measurement input signal from the operation unit 133, outputs control signals to each mechanism in the immunoassay apparatus 101 in order to perform the analysis, and controls the operation of each mechanism.

[0042] The reaction vessel transport mechanism 107 moves above the reaction vessel holding part 108 and descends, holding the unused reaction vessel 121 as it rises. Then, the reaction vessel transport mechanism 107 moves above the reaction vessel setting position L1 of the incubator 106 and descends, placing the unused reaction vessel 121 on the incubator 106.

[0043] Next, the conveying mechanism 107 moves above the reaction vessel holding section 108 and descends, holding the unused sample dispensing tip 128 and rising. Then, the conveying mechanism 107 moves above the tip mounting position L7 and descends, placing the unused sample dispensing tip 128 on the tip mounting position L7. Afterwards, the nozzle of the sample dispensing mechanism 105 moves above the tip mounting position L7 and descends, installing the sample dispensing tip 128 at the tip of the dispensing nozzle of the sample dispensing mechanism 105.

[0044] Next, the nozzle of the reagent dispensing mechanism 112 rotates and moves upward toward the opening 131 of the reagent tray 130 and descends, so that the tip of the nozzle contacts the reagent in the predetermined reagent container 136 and draws in a predetermined amount of reagent. Then, the nozzle of the reagent dispensing mechanism 112 moves to above the reagent discharge position L2 of the incubator 106 and discharges the reagent into the reaction vessel 121 provided in the incubator 106.

[0045] On the other hand, after the sample dispensing tip 128 is installed, the nozzle of the sample dispensing mechanism 105 moves above and descends the sample container 120 disposed on the sample holder 103, drawing in a predetermined amount of sample held in the sample container 120. Then, the nozzle of the sample dispensing mechanism 105 moves to the sample discharge position L3 of the incubator 106 and descends, dispensing the sample into the reaction container 121 containing reagents. After dispensing the sample, the nozzle of the sample dispensing mechanism 105 performs a mixing action. After the mixing action is completed, the nozzle of the sample dispensing mechanism 105 moves above the waste hole 110, discarding the used sample dispensing tip 128 into the waste hole 110.

[0046] Then, the control unit 102 rotates the incubator 106 to move the reaction container 121 containing the sample and reagents to the reaction container setting position L1, and the reaction container 121 is transported to the reaction container stirring mechanism 109 by the conveying mechanism 107.

[0047] The reaction vessel stirring mechanism 109 applies rotational motion to the reaction vessel 121 to mix the sample and reagents within the reaction vessel 121. Afterward, the control unit 102 uses the conveying mechanism 107 to return the reaction vessel 121, after stirring, to the reaction vessel setting position L1 of the incubator 106.

[0048] According to the analysis protocol, the control unit 102 selectively performs the B / F separation process described below based on the measurement items. First, the reaction vessel 121, which has been in the incubator 106 for a predetermined time, is moved to the B / F separation conveying position L6 by rotating the incubator 106, and the reaction vessel 121 is conveyed to the B / F separation mechanism 114 by the B / F separation conveying mechanism 113.

[0049] Next, the B / F separation mechanism 114 causes magnetic particles to adhere to the inner wall of the reaction vessel 121. These magnetic particles contain substances that have undergone immunobinding with the analyte present in the reaction solution of the reaction vessel 121. After a predetermined time, the nozzle of the B / F separation reaction solution aspiration mechanism 115 moves upward and downward to the reaction vessel 121, aspirating the reaction solution in the reaction vessel 121 that does not contain magnetic particles.

[0050] Then, the nozzle of the buffer discharge mechanism 116 is moved upward and downward to discharge buffer solution into the reaction vessel 121. Then, the reaction vessel 121 is transported to the B / F separation stirring mechanism 117 by the B / F separation conveying mechanism 113.

[0051] Then, rotational motion is applied to reaction vessel 121 in the B / F separation stirring mechanism 117 to mix the magnetic particles and buffer solution within reaction vessel 121. After mixing of the magnetic particles and buffer solution is complete, reaction vessel 121 returns to the B / F separation conveying position L6 of incubator 106 via B / F separation conveying mechanism 113. The above dispensing and reaction procedures are performed for each assay, for example, in 12-second cycles.

[0052] Next, the detection process for detecting the analyte in the reaction solution in the detection unit 119 will be described in detail below. First, the reaction container 121, which has been dispensed with the sample and reagent and has undergone a predetermined time on the incubator 106, or the reaction container 121 that has undergone B / F separation, is moved to the detection reaction solution aspiration position L4 by rotating the incubator 106. When the reaction container 121 moves to the detection reaction solution aspiration position L4, the nozzle of the detection reaction solution aspiration mechanism 118 moves upward and downward to aspirate the reaction solution in the reaction container 121. The reaction solution is then conveyed to the flow cell type detection unit 119 (first detection unit 119A or second detection unit 119B) via the liquid delivery path 132, where the analyte is detected. The choice between the first detection unit 119A and the second detection unit 119B is determined according to the specifications of the measurement item. In addition, there are cases where the detection unit used in the measurement item is not specified. In such cases, the control unit 102 can appropriately select the detection unit currently in standby.

[0053] The control unit 102 derives the measurement results (such as the concentration of the target substance in the sample) based on the detection value of the target substance detected by the detection unit 119, and stores them in the storage unit 135. The measurement results can also be displayed on a display unit 134, such as a monitor. Furthermore, the control unit 102 moves the reaction container 121, after the reaction liquid has been drawn in, to the reaction container disposal position L5 by rotating the incubator 106, and moves the reaction container 121 from the incubator 106 to above the disposal port 110 via the conveying mechanism 107, and then disposes of it through the disposal port 110.

[0054] The above testing procedures can be performed in the first testing unit 119A or the second testing unit 119B for each test item, for example, in a 24-second cycle.

[0055] like Figure 1 Like the immunoassay analyzer 101, the detection unit 119 has multiple detection units (119A, 119B), which allows measurements to be performed in parallel across multiple detection units, thereby reducing the measurement time. For example, when two measurements are performed in parallel by two detection units 119A and 119B, the parallel time is 12 seconds, so the total measurement time becomes 24 + 12 = 36 seconds (reduced by 12 seconds).

[0056] However, in the assay, sometimes the detection unit (119A or 119B) to be used is specified. For example, in an immunoassay apparatus with two detection units, for a certain assay, since only the first detection unit 119A has calibration data, it is sometimes specified that the assay should be performed in the first detection unit 119A. Additionally, sometimes the detection unit is specified on the GUI according to the assay; in this case, it is also possible that only one of multiple detection units may be specified.

[0057] In such a situation, if the same detection unit is repeatedly specified in consecutive measurement numbers, only one of the multiple detection units will be used consecutively, while the others will remain idle. This results in an increase in the total analysis time. (Refer to...) Figure 2 To explain the issue in more detail.

[0058] exist Figure 2 In the example, such as Figure 2 As shown in table (a), for tests numbered 1 to 6, the sample (a or b) and test items (A to F) are indicated. Furthermore, test unit 1 is designated for test items A, B, and C, and test unit 2 is designated for test items D, E, and F. The sample is dispensed for each test item over 12 seconds, and all six tests are performed over a period of 6 × 12 = 72 seconds. Figure 2 In the table, (1) and (2) indicate the type of the specified detection unit (first detection unit 119A or second detection unit 119B).

[0059] Figure 2 In the example, measurement numbers 1 to 3 indicate measurement items A to C respectively, but the first detection unit 119A is indicated in each measurement item ((1)). Furthermore, measurement numbers 4 to 6 indicate measurement items D to F respectively, but the second detection unit 119B is indicated in each measurement item ((2)).

[0060] If according to Figure 2 The dispensing operation is performed in the order of the measurement numbers (1-6) shown in Table (a), and the detection operation is performed in the dispensing order. After three consecutive detections by the first detection unit 119A, three consecutive detections by the second detection unit 119B are performed. In this case, during the execution of the detection operation of the first detection unit 119A, the second detection unit 119B remains idle and does not operate; conversely, during the execution of the detection operation of the second detection unit 119B, the first detection unit 119A remains idle and does not operate. That is, except for the timing of switching from measurement number 3 to 4, the first detection unit 119A and the second detection unit 119B cannot operate in parallel, resulting in a longer total analysis time. Figure 2 In the example case, by simply reducing the parallel action time by 12 seconds, the total analysis time, including 6 measurements, becomes 24 × 6 - 12 = 132 seconds. In other words, although the time required for individual measurements is 72 seconds, the inability to perform parallel measurements results in a total detection time of 132 seconds.

[0061] Therefore, in the immunoassay apparatus 101 of the first embodiment, when multiple assays consecutively specify assay items indicating the same detection unit, an operation is performed to change the order of sample dispensing so as to prevent the same detection unit from being dispensed consecutively. (See also...) Figure 3 This will explain in more detail the process of changing the order of sample distribution.

[0062] Figure 3 This is a schematic diagram illustrating the operation of the first embodiment. (As shown) Figure 3 As shown in (a), with Figure 2 Similarly, consider the case where six test numbers are specified. In this first embodiment, when the same detection unit is specified in consecutive test numbers, the control unit 102 performs an operation to change the order of sample dispensing so as not to make the same detection unit consecutive.

[0063] exist Figure 3In example (a), the measurement items (measurement numbers 1 to 3) of the first detection unit 119A are specified three times consecutively. Similarly, the measurement items (measurement numbers 4 to 6) of the second detection unit 119B are specified three times consecutively. Therefore, after the dispensing operation related to measurement number 1 (sample a, measurement item A) is completed, the control unit 102 checks the detection unit specified for the next measurement item, measurement number 2. The control unit 102 determines that the same detection unit (first detection unit 119A) has been specified consecutively and changes the dispensing order. Figure 3 In example (a), the second detection unit 119B, which is different from the first detection unit 119A specified by measurement number 1, is measurement number 4. Therefore, after the dispensing operation of measurement number 1 is completed, the control unit 102 skips measurement numbers 2 and 3 (hereinafter, such an operation is referred to as "dispensing skip operation") and jumps to measurement number 4 to perform the dispensing operation.

[0064] Similarly, after the dispensing operation for measurement number 4 is completed, the dispensing operation for measurement number 5 is performed in the usual order. However, measurement number 5, like measurement number 4, includes measurement item E designated for the second detection unit 119B. The same applies to measurement number 6. Therefore, the control unit 102 skips measurement numbers 5 and 6 and jumps to measurement number 2, whose dispensing operation has not yet been completed.

[0065] Similarly, the control unit 102 reverses the order of dispensing operations to dispense the sample, so that the measurement numbers of the same testing unit are not consecutive in the measurement items. Figure 3 In the case of determination numbers 1 to 6 as in (a), such as Figure 3 As shown in (b), the dispensing operation is performed in the order of measurement numbers 1, 4, 2, 5, 3, and 6. This operation minimizes the occurrence of consecutive use of the same detection unit in consecutive measurement items (measurement numbers). When the occurrence of consecutive use of the same detection unit decreases, as... Figure 3 As shown in (c), the first detection unit 119A and the second detection unit 119B have more opportunities to operate in parallel, which correspondingly shortens the total analysis time. For example, if the time required for fractionation is 72 seconds, performing parallel measurements can reduce the total analysis time to, for example, 84 seconds.

[0066] Reference Figure 4 The flowchart describes the details of the sample dispensing operation in the first embodiment. The sample dispensing operation is controlled in the control unit 102.

[0067] When the sample dispensing operation begins, firstly, a sample holder 103 carrying multiple samples is transferred to the immunoassay analyzer 101 (step S301). While the sample holder 103 is being transferred, the control unit 102 confirms the measurement items for each sample according to the order of the measurement numbers (step S302). For example, the immunoassay analyzer 101 uses a barcode detector (not shown) to read the barcode affixed to the sample container 120 to identify the measurement items for each sample and the detection unit designated for those measurement items (step S302). The barcode and barcode detector are merely one example of the structure used to confirm the measurement items; their form is not limited as long as they can provide information about the measurement items and the designated detection units to the control unit 102.

[0068] If the barcode (measurement item and detection section) reading is completed in step S302, the specimen rack 103 moves along the rack conveyor line 104 to the specimen discharge position L3 (step S303). If the movement is completed, it waits until the dispensing operation begins. Furthermore, multiple specimen racks can wait on the rack conveyor line 104. If the dispensing operation of the specimen rack 103 related to the previous measurement number has not been completed, the new specimen rack 103 waits in the retreat position until the dispensing of the previous specimen rack 103 is completed, and then moves to the specimen discharge position.

[0069] Once the specimen holder 103 has moved to the specimen discharge position L3, the specimen dispensing mechanism 105 dispenses the amount of specimen corresponding to the measurement protocol shown in the measurement item into the reaction container 121 (step S304).

[0070] Next, confirm whether the dispensing of all samples and all test numbers in the sample holder 103 located at the current sample discharge position L3 is complete (step S305A). If the dispensing of all samples and all test numbers is complete ("Yes" in step S305A), confirm whether the next sample holder 103 is ready on the shelf transfer line 104 (step S309A). If the next sample holder 103 is ready on the shelf transfer line 104, repeat the same sample dispensing operation. If there is no next sample holder 103 on the shelf transfer line 104 ("No" in step S309A), the assay ends, or the device is moved to standby mode (step S310). Here, "standby mode" refers to a state where sample dispensing can begin immediately after the sample holder is transferred to the immunoassay device 101.

[0071] On the other hand, if it is determined that the dispensing of all samples and all test numbers within the sample holder 103 at the current sample discharge position L3 has not been completed (No in step S305A), it is confirmed whether the test item involved in the next test number has designated the same detection unit as the test item involved in the previous test (step S306A). If the same detection unit is not designated (No), the operation proceeds to step S311A. On the other hand, if the same detection unit is designated (Yes), the operation proceeds to step S307A.

[0072] In step S311A, it is further determined whether the specimen involved in the next test item is the same specimen as the specimen involved in the previous test number. If it is the same specimen ("Yes" in step 311A), the specimen holder 103 is not moved, and the specimen is dispensed from the same specimen container 120 as before. If it is not the same specimen ("No" in step 311A), the specimen holder 103 is moved to the position of the specimen involved in the test item, and the same specimen is dispensed.

[0073] In step S307A, to avoid continuously specifying the same detection section, the measurement numbers of measurement items with the same specified detection section are skipped (segment skipping action). Instead, it is determined whether the specimens involved in the measurement numbers of measurement items with different specified detection sections exist in the specimen holder 103. If a specimen exists ("Yes" in step S307A), the operation proceeds to step S313. If no specimen exists ("No" in step S307A), the operation proceeds to step S308A. In step S313, the amount and direction of movement of the specimen holder 103 are confirmed, for example, based on the output of the barcode detector described above, and the specimen holder is moved (step S314).

[0074] If there is no corresponding specimen in the specimen holder 103 located at the current specimen discharge position L2 (No in step 307A), it is determined whether a dispensing skipping action was previously performed in the specimen holder 103 (step S308A). The control unit 102 can store whether a dispensing skipping action was performed as history data and perform the determination in step S308A according to the history data. If a dispensing skipping action was performed (Yes), the action proceeds to step S313, and the same action as above is performed. On the other hand, if a dispensing skipping action was not performed (No), the action proceeds to step S309A, and the same action as above is performed.

[0075] As explained above, in the first embodiment, the sample dispensing operation is preferably performed in parallel by multiple detection units, and then the order of the measurement numbers is considered. Therefore, the sample holder 103 usually moves in the forward direction, but if it is determined that the same detection unit has been continuously designated, the movement direction may be switched to move the sample holder 103 in the reverse direction, unlike usual. The above sample dispensing is repeated until all measurement items of the sample placed on the sample holder are completed. That is, in the first embodiment, in order to perform measurements alternately in multiple detection units within the possible range, the sample holder is moved according to the measurement items. As a result, parallel measurements can be performed in multiple detection units, and the total analysis time can be shortened.

[0076] Furthermore, this embodiment describes the case where the measurement order within the same specimen holder 103 is changed, but it is not limited to this; the same operation can also be performed across multiple specimen holders. In this case, the measurement information of multiple specimen holders is confirmed, and the order of dispensing operations is changed among the multiple specimen holders.

[0077] [Second Implementation]

[0078] Next, refer to Figure 5 The automatic analysis device of the second embodiment will be described. Figure 5 This is a schematic diagram illustrating part of the structure of the automated analysis device (immunoassay device) according to the second embodiment. The immunoassay device of the second embodiment, in addition to... Figure 5 Except for the parts shown, the structure is the same as in the first embodiment, therefore repeated descriptions are omitted below. The difference between the second embodiment and the first embodiment is that while the first embodiment used a linear specimen holder 103, the second embodiment uses specimen holders 501 and 505 that can move circumferentially. Figure 5 In this process, the specimen holder 501 is the holder that moves to the specimen dispensing position L3' first, and the specimen holder 505 is the holder that moves to the specimen dispensing position L3' after the dispensing action of the specimen holder 501 is completed.

[0079] like Figure 5 As shown, the immunoassay apparatus of the second embodiment includes a conveyor line 504 configured as a circumferential conveyor path, and the specimen holders 501 and 505 are configured to move along this circumferential conveyor path. The specimen holders 501 and 505 are configured to connect multiple container storage sections. The multiple container storage sections in one specimen holder 501 or 505 are connected, for example, by hinge members, elastic members, etc., and the shape of one specimen holder 501 or 505 can be flexibly changed along the shape of the conveyor path.

[0080] On the other hand, the nozzle of the sample dispensing mechanism 105A is configured to rotate around a rotation axis, and the tip of the nozzle can move along a circumferential path of the rack transport line 504. Therefore, when sample racks 501 and 505 are introduced into the rack transport line 504, the sample dispensing mechanism 105A can access any sample position of the sample racks 501 and 505. Furthermore, the rack transport line 504 is equipped with a brancher 506 capable of switching the travel direction of the sample racks 501 and 505. When switching between the sample rack 501 located at the sample dispensing position L3' and the sample rack 505 waiting at the rear position of the rack transport line 504, the brancher 506 rotates, causing the sample rack 501 located at the sample dispensing position L3' to move rearward. Then, the brancher 506 is rotated in the sample rack travel direction 507, causing the sample rack 505 to move in the sample rack travel direction 507. Then, the brancher 506 is rotated toward the specimen dispensing position L3', causing the specimen rack 505, which is waiting on the rack conveyor line 504, to move toward the specimen dispensing position L3'.

[0081] Reference Figure 6 The flowchart below describes in detail the sample dispensing operation of the immunoassay device according to the second embodiment. The sample dispensing operation is controlled in the control unit 102. Figure 6 Each step S602 to S610 in this embodiment is the same as steps S302 to S310 in the first embodiment, except for the points described below, so repeated descriptions are omitted. However, in this embodiment, step S608A (equivalent to Figure 4 If it is determined in step 308A that the dispensing skipping action has not been performed, after confirming the position of the corresponding specimen in step S613 (step S613), the specimen dispensing mechanism 105A moves to the confirmed position of the specimen (step S614). Other actions are generally the same as in the first embodiment.

[0082] As described above, in the second embodiment, by using specimen holders 501 and 505 that can move circumferentially, the same effect as in the first embodiment can be achieved. Furthermore, in the second embodiment, similar to the first embodiment, the order of dispensing operations can be changed across multiple holders.

[0083] [Third Implementation]

[0084] Next, refer to Figure 7 The automatic analysis device of the third embodiment will be described. Figure 7 This is a schematic diagram illustrating a portion of the structure of the automated analysis apparatus (immunoassay apparatus) according to the third embodiment. The immunoassay apparatus of the third embodiment, in addition to... Figure 7 Except for the parts shown, the structure is the same as the above-described embodiment, so repeated descriptions are omitted below.

[0085] The third embodiment differs from the above embodiment as follows. In the above embodiment, a dispensing skipping operation is performed to change the dispensing order of the specimens according to the detection unit specified for the measurement item. This third embodiment also performs the same operation in principle, but when performing the dispensing skipping operation, a sub-specimen is generated and placed in an area that can be temporarily stored (hereinafter referred to as "sub-specimen area 701"). The sub-specimen is the amount of specimen required to perform a measurement for a certain measurement item. Multiple sub-specimens can be generated in the sub-specimen area 701, but the number is not limited to a specific quantity.

[0086] like Figure 7 As shown, in this third embodiment, a sub-sample area 701 for temporarily storing sub-samples is provided on the circumference of the nozzle movement of the sample dispensing mechanism 105B. When performing a dispensing skip operation, a reaction container 121 can be placed into the sub-sample area 701 via the reaction container transport mechanism 107. Furthermore, the sample holder 103 and holder transport line 104 are the same as in the first embodiment, but the same sample holder and holder transport line as in the second embodiment may also be used.

[0087] Reference Figure 8A and Figure 8B The flowchart below details the sample dispensing operation of the immunoassay device in the third embodiment. Figure 8A and Figure 8B The flowchart of a series of sample dispensing operations is shown. The sample dispensing operations are controlled in the control unit 102. Figure 8A Steps S801 to S809 in the first embodiment are the same as those in the first embodiment. Figure 4 Steps S302 to S306A, S311A, and S312 are largely the same. Therefore, repeated explanations are omitted. When different detection units with consecutive measurement numbers are specified, the operation cycles between steps S801 to S806A to S808A.

[0088] In step S806A, if it is confirmed that the detection unit specified for the test item involved in the next test number is the same as the detection unit specified for the test item involved in the previous test number, the above-described sub-sample preparation step begins. First, in step S807A, it is determined whether the sample involved in the next test number is the same as the sample involved in the previous test number.

[0089] If the result of the determination is positive (yes), then the process proceeds to step S811 without going through step S810; if the result is negative (no), then the process proceeds to step S811 after going through step S810. In step S810, the specimen holder is moved by one specimen quantity, and then a sub-sample with a different test number than the previous test number is created in sub-sample area 701 (step S811). If the next test number is the same as the previous test number ("yes" in step S807A), a sub-sample with the same test number as the previous test number is created in sub-sample area 701 (step S811).

[0090] Then, in order to dispense the sample for the next test number, the sample holder 103 is moved by one sample volume (step S812). It is determined whether the moved sample is the final sample in the sample holder 103 at the current sample dispensing position (step S813A).

[0091] If it is not the final sample (No in step S813A), the sample is dispensed from the undispensed sample container in the sample holder 103 (step S814), and then the process moves to step S815A. On the other hand, if it is the final sample (Yes in step S813A), the process moves to step S817A.

[0092] In step S815A, it is confirmed whether a sub-sample from a detection unit different from the one specified in the previous measurement number exists in the sub-sample area 701 (step S815A). If such a sub-sample exists in the sub-sample area 701 ("Yes" in step S815A), the corresponding sub-sample is dispensed from the sub-sample area 701 (step S816). Steps S815A and S816 are repeated until such a sub-sample disappears from the sub-sample area 701.

[0093] If a sub-sample in sub-sample area 701 has a different detection section than the one specified in the previous test number, then by dispensing the sub-sample, tests can be performed alternately (in parallel) on two detection sections. However, if no such sub-sample exists in sub-sample area 701 ("No" in step S815A), the detection section specified for the next test number is checked to see if it is the same as the sample targeted by the previous test number (step S819A).

[0094] If it is determined that the samples are not the same (No in step S819A), the sample holder is moved by one sample volume in order to dispense the next sample (step S812). On the other hand, if it is determined that the samples are the same (Yes in step S819A), it is confirmed whether the test item involved in the next test number has designated the same detection unit as the previous test number (step S820A).

[0095] If it is determined that a different detection unit has been designated (No in step S820A), the specimen holder is not moved, and the specimen dispensing continues from the same position. On the other hand, if it is determined that the same detection unit has been designated (Yes in step S820A), the step of making a sub-specimen in the sub-specimen area 701 is performed in the same way as described above (step S811).

[0096] Repeat steps S811 to S816 as described above until the measurement of all test numbers for a single specimen rack is completed. Then, if the specimen becomes the final specimen in that specimen rack 103 ("Yes" in step S813A), dispense all unmeasured sub-samples stored in the sub-sample area 701 (step S818), completing the dispensing of the final specimen in the specimen rack 103 (step S822). After dispensing, repeat the same specimen dispensing operation for other specimen racks as described above, until the measurement is completed or the system moves to a standby state (steps S823, S824).

[0097] As described above, in the third embodiment, by alternately using multiple detection units, measurements can be performed in parallel across multiple detection units. In this case, the execution of this step becomes easier by generating a sub-sample in the sub-sample region 701.

[0098] [Fourth Implementation]

[0099] Next, refer to Figure 9 The automatic analysis device of the fourth embodiment will be described. Figure 9 This is a schematic diagram illustrating part of the structure of the automated analysis apparatus (immunoassay apparatus) according to the fourth embodiment. The immunoassay apparatus of the fourth embodiment, in addition to... Figure 9 Except for the parts shown, the structure is the same as the above-described embodiment, so repeated descriptions are omitted below.

[0100] The fourth embodiment differs from the third embodiment as follows. In the third embodiment, when the same detection unit is continuously designated, a structure is adopted in which the sub-sample is temporarily stored in the sub-sample area 701. In contrast, in this fourth embodiment, a structure is adopted in which the sub-sample is temporarily stored in the incubator 106 when the same detection unit is continuously designated.

[0101] like Figure 9 As shown, the immunoassay apparatus of the fourth embodiment, in addition to the sample dispensing mechanism 105C, has the same... Figure 1 The structure is largely the same. In the fourth embodiment, similar to the embodiments described above, a dispensing skip operation is performed when the same detection unit is continuously specified. In this case, the reaction container 121 for preparing the subsample is transported to a predetermined position on the incubator 106 via the reaction container transport mechanism 107. The number of reaction containers 121 is set according to the number of times the dispensing skip operation is performed. When the reaction container 121 for the subsample is placed on the incubator 106, the reaction container transport mechanism 107 can access the predetermined position on the incubator 106; conversely, the incubator 106 can access the reaction container transport mechanism 107 side by rotating the incubator 106.

[0102] Furthermore, to shorten the preparation time of sub-samples, the sample dispensing mechanism 105C can simultaneously draw from the sample holder 103 samples belonging to multiple assay numbers that have skipped the dispensing skipping action and become the objects of sub-sample generation. The samples drawn together are then dispensed into multiple reaction containers 108 according to the multiple assay numbers.

[0103] Multiple samples with different test numbers are sequentially discharged into multiple reaction containers 121, for example, by rotating the incubator 106. For example, if three tests with a sample dispensing volume of 10 μL are skipped, three reaction containers 121 are set on the incubator 106. Then, the sample dispensing mechanism 105C, for example, draws 30 μL of sample from the sample holder 103 and dispenses 10 μL into each of the three reaction containers 121 placed in the incubator 106.

[0104] In the third embodiment described above, a subsample is prepared in the subsample area 701, and then the sample is dispensed from the subsample area 701 into the incubator 106. In contrast, in the fourth embodiment, the sample is dispensed into the reaction vessel 121 at the same time as the subsample is prepared in the incubator 106, thus eliminating the need for subsample dispensing as in the third embodiment. Therefore, according to this fourth embodiment, similar to the first and second embodiments, the dispensing order can be changed according to the content of the measurement, allowing multiple detection units to perform parallel measurements.

[0105] [Variation Example]

[0106] Next, refer to Figure 10 as well as Figure 11 The automatic analysis apparatus for each embodiment will be described. Figure 10This is a schematic diagram illustrating a portion of the structure of the automated analytical apparatus (immunoassay apparatus) of the first modified example. In this first modified example, the sample dispensing mechanism 105D includes a rotating shaft 1001 and a dispensing nozzle 1002. The rotating shaft 1001 is rotatable about the rotating shaft O1. Furthermore, the dispensing nozzle 1002 is configured to rotate about the rotating shaft O2 located at the front end of the rotating shaft 1001. Thus, unlike the sample dispensing mechanism of the above-described embodiment, the sample dispensing mechanism 105D has two rotating parts and two rotating shafts, thereby allowing access to any position of the sample holder 103 and the incubator 106.

[0107] Figure 11 This is a schematic diagram illustrating part of the structure of the automated analysis (immunoassay apparatus) of the second modification. In the above embodiment, a sample holder contains multiple sample containers, which are transported via a holder transport line. In contrast, in this second modification, sample containers 1101, 1104... are transported along the holder transport line 1102. Sample containers 1101, 1104... can move not only along the long side of the holder transport line 1102 but also along its short side via magnetic transport or the like.

[0108] In this second variation, the specimens are dispensed in principle in the order of arriving at the specimen dispensing position 1103 along the conveyor line 1102. However, similar to the above embodiment, when the test numbers of the test items designated for the same test section are consecutive, the order of specimen dispensing can be appropriately changed.

[0109] Next, a third modification will be described. In this third modification, in the above embodiment, the following operations can be performed: the immunoassay apparatus is connected to the sample transport and sample transport pretreatment unit, and the configuration of the sub-samples is pre-arranged according to the order of the test items when preparing the sub-samples. That is, the test items are identified before the sample is introduced into the apparatus, and when the sub-samples are prepared from the parent sample by the sample transport pretreatment unit, the configuration order of the sub-samples can be pre-arranged in a manner that allows for alternating detection by multiple detection units.

[0110] Next, the fourth variation will be described. In the above embodiment, when the measurement numbers of the same detection unit are consecutive, the measurement can be performed alternately (in parallel) by changing the sample dispensing steps, etc. In contrast, in the fourth variation, unlike such dispensing step changes, the control unit 102 stores the history of dispensing skips and measurement sequence changes, and recommends changes to the detection unit specified for the measurement item based on this history data. The history data of measurement sequence changes can be stored in the storage unit 135. Furthermore, a computer program executed in the control unit 102 can determine whether to recommend a change of detection unit based on the history data.

[0111] For example, in an immunoassay analyzer that has performed X or more assays, if the number of sorting attempts exceeds a threshold A, it can be presumed that a deviation has occurred in the detection unit specified during the assay. By changing the detection unit specified in any assay, it is possible to calculate, based on historical data, the extent to which the number of sorting attempts can be reduced. If the calculated value is below a threshold B, a message recommending a change to the specified detection unit (e.g., ...) will be sent. Figure 12 Such a message is displayed on display unit 134. The operator can use this information to determine whether the testing unit specified in each measurement item should be changed.

[0112] This invention is not limited to the embodiments described above and includes various modifications. For example, the above embodiments are detailed descriptions provided for ease of understanding of the invention and are not limited to having all the described structures. Furthermore, a portion of the structure of one embodiment can be replaced with a structure of another embodiment, and a structure of another embodiment can be added to the structure of one embodiment. Additionally, for a portion of the structure of each embodiment, other structures can be added, deleted, or replaced.

[0113] Symbol Explanation

[0114] 101 Immunoassay Analyzer (Automated Analyzer); 102 Control Unit; 103, 505 Specimen Holders; 104, 504 Holder Transfer Lines; 105, 105A, 105B-D Specimen Dispensing Mechanisms; 106 Incubator; 107 Reaction Vessel Transfer Mechanism; 108 Reaction Vessel Holding Unit; 109 Reaction Vessel Stirring Mechanism; 110 Waste Disposal Hole; 111 Reagent Tray; 112 Reagent Dispensing Mechanism; 113 B / F Separation Transfer Mechanism; 114 B / F Separation Mechanism; 115 B / F Separation Reaction Solution Aspiration Mechanism; 116 Buffer Discharge Mechanism; 117 B / F Separation Post-Separation Stirring Mechanism; 118 Detection Reaction Solution Aspiration Mechanism; 119, 119A, 119B Detection Unit (Analysis Unit); 120 Specimen Container; 121 Reaction Vessel; L1 Reaction Vessel Setting Position; L2 Reagent Discharge Position; L3 Specimen Discharge Position; L4 Detection Reaction Solution Aspiration Position; L5 Reaction Vessel Waste Position; L6 B / F separation and transport position; L7 pipette tip installation position; 128 sample dispensing pipette tip; 130 reagent tray cover; 131 opening; 132 liquid delivery path; 133 operating section; 134 display section; 135 storage section; 501, 505 sample rack; 506 brancher; 507 sample rack travel direction; 701 sub-sample area.

Claims

1. An automatic analysis device, characterized in that, have: Specimen rack, used to store specimens; A sample dispensing mechanism that draws the sample from the sample holder and dispenses it into the reaction container; Multiple detection units that detect the reaction liquid being delivered from the reaction vessel; and The control unit controls the sample dispensing mechanism and the detection unit. For each of the aforementioned reaction vessels, one sample dispensing mechanism and multiple detection units are provided. The control unit is provided with information on the specified test items for the specimen and one of the plurality of test items specified in the test items. Based on the provided information, if the same detection unit is specified among the plurality of detection units in consecutive measurements, the control unit changes the dispensing order of the sample dispensing mechanism so that different detection units can be used in the consecutive measurements.

2. The automatic analysis device according to claim 1, characterized in that, When measurements of the same detection unit are continuously specified, the control unit switches the movement direction of the specimen holder.

3. The automatic analysis device according to claim 2, characterized in that, The specimen structure is designed to move linearly along a conveyor line, which is configured to be linear.

4. The automatic analysis device according to claim 2, characterized in that, The specimen structure is configured to move circumferentially along a conveyor line, which is configured to be circumferential. The sample dispensing mechanism is configured to rotate about a rotation axis so that the front end of the nozzle of the sample dispensing mechanism moves along the circumferentially shaped conveyor line.

5. An automatic analysis device, characterized in that, have: Specimen rack, used to store specimens; A sample dispensing mechanism that draws the sample from the sample holder and dispenses it into the reaction container; Multiple detection units detect the reaction liquid being delivered from the reaction vessel; A control unit that controls the sample dispensing mechanism and the detection unit; and The sub-sample area is configured to temporarily store the sample as a sub-sample. The control unit is provided with information on the specified test items for the specimen and one of the plurality of test items specified in the test items. When the same detection unit is designated among the plurality of detection units in continuous measurements based on the provided information, the control unit performs the following actions: in order to change the dispensing order of the sample dispensing mechanism so as to use different detection units in the continuous measurements, the reaction container is set in the sub-sample area, the sub-sample is dispensed into the reaction container by the sample dispensing mechanism, and temporarily stored in the sub-sample area.

6. An automatic analysis device, characterized in that, have: Specimen rack, used to store specimens; A sample dispensing mechanism that draws the sample from the sample holder and dispenses it into the reaction container; Multiple detection units detect the reaction liquid being delivered from the reaction vessel; A control unit that controls the sample dispensing mechanism and the detection unit; and An incubator that promotes the reaction in the reaction vessel. The control unit is provided with information on the specified test items for the specimen and one of the plurality of test items specified in the test items. When the same detection unit is designated among the plurality of detection units in continuous measurements based on the provided information, the control unit performs the following actions: in order to change the dispensing order of the sample dispensing mechanism so as to use different detection units in the continuous measurements, the reaction container is set in the incubator, the sub-sample is dispensed into the reaction container by the sample dispensing mechanism, and temporarily stored in the incubator.

7. An automatic analysis device, characterized in that, have: Specimen rack, used to store specimens; A sample dispensing mechanism that draws the sample from the sample holder and dispenses it into the reaction container; Multiple detection units detect the reaction liquid being delivered from the reaction vessel; as well as The control unit controls the sample dispensing mechanism and the detection unit. The control unit is provided with information on the specified test items for the specimen and one of the plurality of test items specified in the test items. Based on the provided information, if the same detection unit is assigned among the plurality of detection units in consecutive measurements, the control unit will change the dispensing order of the sample dispensing mechanism so that different detection units can be used in the consecutive measurements. When the control unit determines that changing the detection unit specified for the measurement item can reduce the number of times the dispensing order can be changed, the display unit will display the content.

8. A control program product for an automated analysis device, said control program product controlling the dispensing of samples in the automated analysis device, characterized in that, The automatic analysis device includes: Specimen rack, used to store specimens; A sample dispensing mechanism that draws the sample from the sample holder and dispenses it into the reaction vessel; and Multiple detection units detect the reaction liquid being delivered from the reaction vessel. Furthermore, the automatic analysis device is equipped with one sample dispensing mechanism and multiple detection units for each reaction vessel. The control program product is configured to cause the automatic analysis device to perform the following actions: Information is provided regarding the specified assay items for the specimen and one of the plurality of detection sections specified in the assay items; as well as Based on the information provided, in the case where the same detection unit is specified among the plurality of detection units in consecutive measurements, the dispensing order of the sample dispensing mechanism is changed so that different detection units can be used in the consecutive measurements.

9. The control program product according to claim 8, characterized in that, When measurements of the same detection unit are continuously specified, the movement direction of the specimen holder is switched.

10. A control program product for an automated analysis device, the control program product controlling the dispensing of samples in the automated analysis device, characterized in that, The automatic analysis device includes: Specimen rack, used to store specimens; A sample dispensing mechanism that draws the sample from the sample holder and dispenses it into the reaction container; Multiple detection units that detect the reaction liquid being delivered from the reaction vessel; and The sub-sample area is configured to temporarily store the sample as a sub-sample. The control program product causes the automatic analysis device to perform the following actions: Information is provided regarding the specified assay items for the specimen and one of the plurality of detection sections specified in the assay items; Based on the provided information, in the case where the same detection unit is specified among the plurality of detection units in continuous measurements, in order to change the dispensing order of the sample dispensing mechanism so that different detection units can be used in the continuous measurements, the reaction container is set in the sub-sample area, the sub-sample is dispensed into the reaction container by the sample dispensing mechanism, and temporarily stored in the sub-sample area.

11. A control program product for an automated analysis device, said control program product controlling the dispensing of samples in the automated analysis device, characterized in that, The automatic analysis device includes: Specimen rack, used to store specimens; A sample dispensing mechanism that draws the sample from the sample holder and dispenses it into the reaction container; Multiple detection units that detect the reaction liquid being delivered from the reaction vessel; and An incubator that promotes the reaction in the reaction vessel. The control program product causes the automatic analysis device to perform the following actions: Information is provided regarding the specified assay items for the specimen and one of the plurality of detection sections specified in the assay items; as well as Based on the information provided, in the case where the same detection unit is specified among the plurality of detection units in continuous measurements, in order to change the dispensing order of the sample dispensing mechanism so as to use different detection units in the continuous measurements, the reaction container is set in the incubator, the sub-sample is dispensed into the reaction container by the sample dispensing mechanism, and temporarily stored in the incubator.

12. A control program product for an automated analysis device, said control program product controlling the dispensing of samples in the automated analysis device, characterized in that, The automatic analysis device includes: Specimen rack, used to store specimens; A sample dispensing mechanism that draws the sample from the sample holder and dispenses it into the reaction vessel; and Multiple detection units detect the reaction liquid being delivered from the reaction vessel. The control program product is configured to cause the automatic analysis device to perform the following actions: Information is provided regarding the specified assay items for the specimen and one of the plurality of detection sections specified in the assay items; as well as Based on the provided information, when the same detection unit is specified among the plurality of detection units in consecutive measurements, the dispensing order of the sample dispensing mechanism is changed so that different detection units can be used in the consecutive measurements. If it is determined that changing the detection section specified for the measurement item can reduce the number of times the dispensing order can be changed, the display section will display this content.

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