An isovolumetric plasma exchange system

Abstract

The present invention discloses an isobaric replacement plasma exchange system, comprising a blood draw tube, a blood filter is provided on the blood draw tube, an anticoagulant bag is connected to the blood draw tube through the third channel of a second isobaric replacement pump, the blood draw tube is connected to the whole blood inlet of a plasma separator, the plasma outlet of the plasma separator is connected to a waste bag through the first channel of a first isobaric replacement pump, the blood cell outlet of the plasma separator is connected to a return pipe, a replacement fluid bag is connected to the replacement pipe through the second channel of the first isobaric replacement pump, the replacement pipe is connected to the return pipe, and the replacement pipe is connected to the replacement fluid bag through the fourth channel of the second isobaric replacement pump. The beneficial effects of the present invention: the existing replacement fluid delivery pump system is simplified, and the equal amount of replacement fluid is supplemented by the cooperation of two double-tube peristaltic pumps at the same time, and no other operations are required, the overall structure is simple, the operation is convenient and reliable, and accurate plasma exchange is achieved.

Description

Technical Field

[0001] The invention belongs to the technical field of blood replacement, in particular to an equal volume replacement plasma replacement system. Background Art

[0002] Plasma exchange is one of the important means of purifying blood in the treatment of modern blood diseases and other related diseases. The basic principle of plasma exchange is to use a blood separator to separate the patient's blood into plasma and blood cell components in vitro, then discard the plasma containing harmful pathogenic factors, replace the plasma with an equal amount of replacement fluid, and then return the blood cell components and replacement fluid to the patient.

[0003] Since blood contains coagulation factors, it must be anticoagulated in time after it is taken out of the human body to form anticoagulated whole blood for plasma separation. After the separation is completed, the discarded plasma includes a portion of anticoagulants, and the replacement fluid needs to be consistent with the actual volume of plasma lost by the human body. At present, the replacement fluid is delivered to the human body through a separate pump system, which cannot accurately achieve the same amount of replacement fluid delivery.

[0004] Therefore, there is an urgent need for a new plasma exchange system that can solve the above-mentioned problems. Summary of the invention

[0005] The purpose of the present invention is to provide an equal volume replacement plasma exchange system to solve the problem that the replacement fluid and the volume of plasma lost by the human body cannot be accurately replaced in equal volume during plasma exchange, and the existing problem of troublesome operation caused by independent delivery of the replacement fluid.

[0006] The object of the present invention is achieved through the following technical solutions:

[0007] A plasma exchange system for isobaric exchange comprises a blood drawing blood tube, on which a blood filter is arranged, an anticoagulant bag is connected with the blood drawing blood tube through a third channel of a second isobaric exchange pump, the blood drawing blood tube is connected with a whole blood inlet of a plasma separator, the plasma outlet of the plasma separator is connected with a waste bag through a first channel of a first isobaric exchange pump, the blood cell outlet of the plasma separator is connected with a return pipe, a replacement fluid bag is connected with a replacement pipe through a second channel of the first isobaric exchange pump, the replacement pipe is connected with a return pipe, and the replacement pipe is connected with the replacement fluid bag through a fourth channel of a second isobaric exchange pump.

[0008] Furthermore, the first equal volume displacement pump and the second equal volume displacement pump are double-tube peristaltic pumps.

[0009] Furthermore, the inlet of the blood drawing tube is provided with a blood drawing puncture device.

[0010] Furthermore, the third channel is connected to the blood drawing tube through a blood drawing puncture device.

[0011] Furthermore, the blood drawing blood tube is provided with a blood drawing pump.

[0012] Furthermore, the blood pump is a peristaltic pump.

[0013] Furthermore, a blood transfusion pump is provided on the return tube.

[0014] Furthermore, the blood transfusion pump is a peristaltic pump.

[0015] Furthermore, the outlet of the return tube is provided with a blood transfusion puncture device.

[0016] Furthermore, the replacement tube is provided with a tee located between the second channel, the return tube and the fourth channel.

[0017] The beneficial effects of the present invention are as follows: the existing replacement fluid delivery pump system is simplified, and at the same time, equal amount of replacement fluid replenishment is achieved through the cooperation of two double-tube peristaltic pumps without the need for other operations. The overall structure is simple, the operation is convenient and reliable, and accurate plasma exchange is achieved.

[0018] The aforementioned main scheme of the present invention and its further options can be freely combined to form multiple schemes, all of which are schemes that can be adopted and claimed for protection by the present invention; and in the present invention, (non-conflicting options) options and other options can also be freely combined. After understanding the scheme of the present invention, those skilled in the art can understand that there are many combinations based on the prior art and common knowledge, all of which are technical schemes to be protected by the present invention, and they are not exhaustively listed here. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a structural schematic diagram of the present invention.

[0020] Figure 2 It is a schematic diagram of the structure of the equal displacement pump of the present invention.

[0021] In the figure: 1-blood drawing puncture device, 2-blood drawing pump, 3-blood filter, 4-plasma separator, 5-waste bag, 6-replacement fluid bag, 7-anticoagulant bag, 8-first equal volume replacement pump, 9-second equal volume replacement pump, 10-blood transfusion pump, 11-return tube, 12-blood transfusion puncture device, 13-blood drawing tube. DETAILED DESCRIPTION

[0022] The following non-limiting examples serve to illustrate the invention.

[0023] Embodiment 1:

[0024] refer to Figure 1 and Figure 2As shown, a plasma exchange system for equal volume replacement includes a blood drawing puncture device 1, a blood drawing pump 2, a blood filter 3, a plasma separator 4, a waste bag 5, a replacement fluid bag 6, an anticoagulant bag 7, a first equal volume replacement pump 8, a second equal volume replacement pump 9, a blood transfusion pump 10, a return tube 11, a blood transfusion puncture device 12, a blood drawing tube 13 and a replacement tube.

[0025] The inlet of the blood drawing tube 13 is provided with a blood drawing puncture device 1, and the blood drawing tube 13 is provided with a blood drawing pump 2, which is a peristaltic pump. The blood drawing puncture device 1 is connected to the vein of the human body, and the whole blood in the human body is drawn out by the blood drawing pump 2. The blood drawing tube 13 is provided with a blood filter 3, and the blood filter 3 is used to filter and purify the anticoagulated whole blood.

[0026] The anticoagulant bag 7 is connected to the third channel of the second isobaric displacement pump 9. The second isobaric displacement pump 9 is a double-tube peristaltic pump. The rollers of the double-tube peristaltic pump are of uniform size, the diameters of the peristaltic pump tubes are consistent, and the liquid flow rates in the third and fourth channels are consistent, achieving equal flow. The third channel is connected to the blood drawing tube 13 through the blood drawing puncture device 1, and the anticoagulant is pumped out from the anticoagulant bag 7 through the second isobaric displacement pump 9, and the whole blood is mixed with the anticoagulant to form anticoagulated whole blood.

[0027] The blood collection tube 13 is connected to the whole blood inlet of the plasma separator 4, and the plasma separator 4 is used to centrifuge the anticoagulated whole blood to separate the blood into plasma and blood cell components.

[0028] The plasma outlet of the plasma separator 4 is connected to the waste bag 5 through the first channel of the first isobaric displacement pump 8. The first isobaric displacement pump 8 is a double-tube peristaltic pump. The rollers of the double-tube peristaltic pump are of uniform size, the diameters of the peristaltic pump tubes are consistent, and the liquid flow rates in the first and second channels are consistent, so that equal flow is achieved. The first isobaric displacement pump 8 pumps the waste plasma into the waste bag 5.

[0029] The replacement fluid bag 6 is connected to the replacement tube through the second channel of the first equal volume replacement pump 8, and the first equal volume replacement pump 8 pumps the replacement fluid in an amount equal to the discarded plasma into the replacement tube. The replacement tube is connected to the replacement fluid bag 6 through the fourth channel of the second equal volume replacement pump 9, and the second equal volume replacement pump 9 then pumps the replacement fluid in an amount equal to the added anticoagulant out of the replacement tube and flows back into the replacement fluid bag 6.

[0030] The replacement tube is provided with a tee located between the second channel, the return tube 11 and the fourth channel. The replacement tube is connected to the return tube 11, and the replacement fluid after increase or decrease is equal to the plasma volume lost by the whole blood, and then the replacement fluid is input into the return tube 11, and the blood cell outlet of the plasma separator 4 is connected to the return tube 11, and the blood cells and the replacement fluid are mixed in the return tube 11.

[0031] A blood transfusion pump 10 is provided on the return tube 11. The blood transfusion pump 10 is a peristaltic pump. A blood transfusion puncture device 12 is provided at the outlet of the return tube 11. The return tube 11 is connected to the human body by the blood transfusion puncture device 12, and the replaced plasma is re-injected into the human body through the blood transfusion pump 10.

[0032] Workflow:

[0033] During the operation of the first isobaric replacement pump 8 and the second isobaric replacement pump 9, the volume of waste plasma pumped out from the plasma separator 4 by the first isobaric replacement pump 8 is consistent with the volume of replacement fluid pumped out from the replacement fluid bag 6, which contains the volume of plasma and anticoagulant lost by the human body. The second isobaric replacement pump 9 pumps the anticoagulant from the anticoagulant bag 7 into the whole blood vessel circuit, and at the same time, the second isobaric replacement pump 9 returns an equal amount of replacement fluid to the replacement fluid bag, thereby returning a portion of the replacement fluid pumped out by the first isobaric replacement pump 8 to the return tube 11, and then returns to the human body. By cooperating with the first isobaric replacement pump 8 and the second isobaric replacement pump 9, the replacement fluid returned is consistent with the amount of plasma lost by the human body without the need for other operations.

[0034] The above basic examples of the present invention and their further optional examples can be freely combined to form multiple embodiments, all of which are embodiments that can be adopted and claimed for protection by the present invention. In the scheme of the present invention, each optional example can be arbitrarily combined with any other basic examples and optional examples.

[0035] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A plasma exchange system for isovolumetric exchange, comprising a blood collection tube (13), characterized in that: The blood extraction tube (13) is provided with a blood filter (3), the anticoagulant bag (7) is connected to the blood extraction tube (13) through the third channel of the second isobaric replacement pump (9), the blood extraction tube (13) is connected to the whole blood inlet of the plasma separator (4), the plasma outlet of the plasma separator (4) is connected to the waste bag (5) through the first channel of the first isobaric replacement pump (8), the blood cell outlet of the plasma separator (4) is connected to the return tube (11), the replacement fluid bag (6) is connected to the replacement tube through the second channel of the first isobaric replacement pump (8), the replacement tube is connected to the return tube (11), and the replacement tube is connected to the return tube (11) through the second isobaric replacement pump (8). The fourth channel of the pump (9) is connected to the replacement fluid bag (6); the liquid flow rates in the third and fourth channels are consistent, achieving equal flow; the anticoagulant is pumped out from the anticoagulant bag through the second equal volume replacement pump, and the whole blood and the anticoagulant are mixed to form anticoagulated whole blood; the liquid flow rates in the first and second channels are consistent, achieving equal flow; the first equal volume replacement pump pumps the waste plasma into the waste bag; the first equal volume replacement pump pumps the replacement fluid in an amount equal to the waste plasma into the replacement tube; the second equal volume replacement pump then pumps the replacement fluid in an amount equal to the amount of the added anticoagulant out of the replacement tube, and returns it to the replacement fluid bag; the blood cells and the replacement fluid are mixed in the return tube.

2. The plasma exchange system for isomeric exchange according to claim 1, characterized in that: The first isobaric displacement pump (8) and the second isobaric displacement pump (9) are double-tube peristaltic pumps.

3. The isomeric plasma exchange system according to claim 1, characterized in that: The inlet of the blood drawing tube (13) is provided with a blood drawing puncture device (1).

4. The isomeric plasma exchange system according to claim 3, characterized in that: The third channel is connected to the blood drawing tube (13) through the blood drawing puncture device (1).

5. The plasma exchange system for isomeric exchange according to claim 1, 3 or 4, characterized in that: The blood drawing blood tube (13) is provided with a blood drawing pump (2).

6. The isomeric plasma exchange system according to claim 5, characterized in that: The blood pump (2) is a peristaltic pump.

7. The isomeric plasma exchange system according to claim 1, characterized in that: The return tube (11) is provided with a blood transfusion pump (10).

8. The isomeric plasma exchange system according to claim 7, characterized in that: The blood transfusion pump (10) is a peristaltic pump.

9. The plasma exchange system for isomeric exchange according to claim 1, 7 or 8, characterized in that: The outlet of the return tube (11) is provided with a blood transfusion puncture device (12).

10. The isomeric plasma exchange system according to claim 1, characterized in that: The replacement tube is provided with a tee located between the second channel, the return tube (11) and the fourth channel.

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