A compound, its preparation method and uses
By reacting trans-4-bromomethylcyclohexane methanol with phthalimide salt to generate an intermediate, and combining an oxidant and a catalyst, the problems of excessive wastewater, low activity, and high cost in existing tranexamic acid synthesis are solved, achieving low-cost and safe tranexamic acid synthesis.
CN115108963BActive Publication Date: 2026-06-30SHANGHAI QIXUN PHARMA TECH CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI QIXUN PHARMA TECH CO LTD
- Filing Date
- 2021-03-19
- Publication Date
- 2026-06-30
AI Technical Summary
Technical Problem
Existing tranexamic acid synthesis processes suffer from high wastewater discharge, low reactivity, high cost, and potential toxic impurities, lacking both green and cost-competitive process routes.
Method used
Trans-4-bromomethylcyclohexane was reacted with methanol and phthalimide salt to generate trans-(N-phthalimidemethyl)-4-hydroxymethyl-cyclohexane, which was then converted to tranexamic acid under the action of oxidant and catalyst. Green synthesis was achieved by controlling the ratio of cis to trans isomers.
Benefits of technology
This provides a low-cost, safe, and quality-controllable synthetic route for tranexamic acid, reducing wastewater discharge, lowering the risk of toxic impurities, and improving synthesis efficiency.
✦ Generated by Eureka AI based on patent content.
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Abstract
This invention discloses a compound, its preparation method, and its uses. The compound is trans-(N-phthalimidemethyl)-4-hydroxymethyl-cyclohexane. The preparation method of this compound includes reacting trans-4-bromomethylcyclohexane methanol with phthalimide or a salt of phthalimide to obtain it, and tranexamic acid can be effectively obtained from this compound.
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