A process for the preparation of a fluoromaximine and analogs thereof

By simplifying the preparation process of flumatinib, using readily available raw materials and optimizing reaction conditions, the problems of expensive starting materials and low yield in existing technologies have been solved, enabling efficient industrial production.

CN115197168BActive Publication Date: 2026-07-24JIANGSU HANSOH PHARMA CO LTD
View PDF 8 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU HANSOH PHARMA CO LTD
Filing Date
2021-04-09
Publication Date
2026-07-24

Smart Images

  • Figure QLYQS_1
    Figure QLYQS_1
  • Figure QLYQS_2
    Figure QLYQS_2
  • Figure QLYQS_3
    Figure QLYQS_3
Patent Text Reader

Abstract

The present application relates to a preparation method of fluorofamide and its analogues, a synthesis method of fluorofamide and its analogues used for treating chronic myelogenous leukemia, and an intermediate obtained in the method. The preparation method has the advantages of easy raw material, simple operation, high product yield, and suitability for industrial production.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Fluoro-substituted compounds as kinase inhibitors and methods of use thereof

    CN102548987B

  • Azaindole derivatives as protein kinase inhibitors

    CN105008355B

  • 3-Ethynylpyrazolopyrimidine derivatives, their preparation methods and uses

    CN105837575B

  • Synthetic method of intermediate of flumatinib mesylate

    CN107663151A

  • Method for synthesizing phenylethanolamines

    CN102477000A