Methods and systems for identifying different types of cancer cells in a patient with renal pelvis cancer based on urine

By analyzing the expression of proto-oncogenes in urothelial cell subsets through single-cell RNA sequencing of urine samples and calculating the cancer cell ratio, this method solves the problem of non-invasive identification of cancer cell types in patients with renal pelvis cancer, provides a reference for neoadjuvant therapy before renal pelvis cancer surgery, and improves the accuracy and effectiveness of treatment.

CN115232875BActive Publication Date: 2026-06-26FOURTH MILITARY MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FOURTH MILITARY MEDICAL UNIVERSITY
Filing Date
2022-08-02
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

The lack of non-invasive methods in current technology to identify different types of cancer cells in in vitro samples from patients with renal pelvis cancer leads to a lack of effective references for neoadjuvant therapy before renal pelvis cancer, affecting treatment outcomes and patient trauma.

Method used

By collecting urine samples and using single-cell RNA sequencing technology to obtain cell expression profiles, we can analyze the proto-oncogene expression data of mixed urothelial cell subsets, calculate the cancer cell ratio, identify different types of cancer cells, and provide a reference for neoadjuvant therapy before renal pelvis cancer surgery.

Benefits of technology

It enables rapid and accurate non-invasive identification of different types of cancer cells in the urine of patients with renal pelvis cancer, providing a basis for neoadjuvant therapy before surgery for renal pelvis cancer and improving the accuracy and effectiveness of treatment.

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Abstract

The present application relates to the field of cancer cell identification, and particularly relates to a method and system for identifying different types of cancer cells of a renal pelvis cancer patient based on urine, the method comprising: collecting a urine sample, obtaining a detection sample by using the urine sample; sequencing the detection sample to obtain a cell expression profile of the detection sample; obtaining cell expression profile data of a mixed urothelial cell subpopulation by using the cell expression profile, the mixed urothelial cell subpopulation comprising normal urothelial cells and cancerous urothelial cells; extracting different proto-oncogene expression data from the cell expression profile data of the mixed urothelial cell subpopulation; analyzing the different proto-oncogene expression data to obtain a cancer cell ratio and identify different types of cancer cells. The present method quickly and accurately obtains different types of cancerous urothelial cells through non-invasive examination and proto-oncogene expression profile data, and provides a reference and basis for preoperative neoadjuvant therapy of renal pelvis cancer.
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