Antigen binding molecules directed against alppl2 and / or alpp and uses thereof
By designing antigen-binding molecules that specifically bind to ALPPL2 without binding to ALPL or ALPI, the challenge of targeting ALPPL2 cancer cell therapies in existing technologies has been solved, achieving highly efficient killing effects and reducing side effects on normal cells, thus providing a new cancer treatment method.
CN115380050BActive Publication Date: 2026-07-03AGENCY FOR SCI TECH & RES
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- AGENCY FOR SCI TECH & RES
- Filing Date
- 2021-02-05
- Publication Date
- 2026-07-03
AI Technical Summary
Technical Problem
Current technology lacks effective targeted antibody therapies to treat cancer cells expressing ALPPL2, and conventional antibodies may have side effects on normal cells.
Method used
Develop antigen-binding molecules that specifically bind to ALPPL2 without binding to ALPL or ALPI, including specific amino acid sequence combinations of heavy chain variable regions and light chain variable regions, enhance affinity for ALPPL2 through humanized antibodies, and conjugate with toxins or radioisotopes to enhance killing effects.
Benefits of technology
This study achieved highly efficient targeted killing of ALPPL2-expressing cancer cells, reduced side effects on normal cells, enhanced the killing effects of ADCC and ADC, and provided a new approach for cancer treatment.
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Smart Images
Figure CN115380050B_ABST
Abstract
This invention relates to antigen-binding molecules that specifically bind to ALPPL2 and / or ALPP but not ALPL or ALPI. The invention also relates to pharmaceutical compositions, immunoconjugates, and chimeric antigen receptors comprising said antigen-binding molecules. Furthermore, the invention relates to methods for reducing the expression or activity of ALPPL2 in cancer cells, and methods for treating cancer in subjects.
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