A multi-electrode pulsed field ablation system with pulse output control

Abstract

A kind of multi-electrode pulse output control's pulsed field ablation system belongs to medical equipment technical field, the present application is to solve the problem of existing pulsed field ablation system slow response, poor flexibility, electrode is easily heated and damaged.It includes: pulse generator and pulse ablation catheter, pulse generator includes multiple parallel connection bridge arm control circuit and the electrode corresponding with bridge arm control circuit, bridge arm control circuit is used to drive corresponding electrode, the potential of bipolar electrode acts on pulse ablation catheter;Bridge arm control circuit includes four power switch tubes, two power diodes and high-voltage relay;Four power switch tubes are sequentially cascaded, power diode is connected in series, and the series branch is connected in parallel with the two power switch tubes located in the middle, the connecting point of the two power switch tubes located in the middle is connected with one end of the normally open contact of high-voltage relay, the other end of the normally open contact of high-voltage relay is connected with electrode.The present application is used for atrial fibrillation ablation.

Description

TECHNICAL FIELD

[0001] The present application relates to a pulse field ablation system, belonging to the technical field of medical equipment. BACKGROUND

[0002] At present, the ablation means for atrial fibrillation mainly adopts two kinds of cryoablation and radiofrequency ablation, but both of the two ablation methods need to contact the tissue to achieve the transmural injury, therefore, it is necessary to find a more rapid, safe and efficient ablation energy. The PFA (pulse field ablation system) has the advantages of short operation time, quick effect and small injury, therefore, the technology of the PFA (pulse field ablation system) is crucial for treating atrial fibrillation of the heart.

[0003] The existing PFA usually adopts a single pulse generating circuit, and supports multiple high-voltage relays to realize multiple high-voltage pulse output to drive multiple catheter electrodes, but it has the following problems:

[0004] 1. The number of high-voltage relays is relatively large, which leads to large size, high cost, long action time and poor flexibility;

[0005] 2. When switching adjacent electrodes and spaced electrodes, the bus supply voltage needs to be adjusted, and it takes a period of time to charge and discharge the high-voltage power supply;

[0006] 3. All electrodes release pulse energy at the same time, the electrodes are seriously heated and are easy to be damaged.

[0007] Therefore, how to realize the driving of multiple catheter electrodes is a problem to be solved in the development of PFA. SUMMARY

[0008] The present application aims to solve the problems of slow response speed, poor flexibility and easy damage of electrodes in the existing pulse field ablation system, and provides a pulse field ablation system with multiple electrode pulse output control.

[0009] The pulse field ablation system with multiple electrode pulse output control comprises a pulse generator and a pulse ablation catheter, the pulse generator comprises multiple bridge arm control circuits connected in parallel and electrodes corresponding to the bridge arm control circuits, the bridge arm control circuit is used for driving the corresponding electrode, and the potential of the bipolar electrode acts on the pulse ablation catheter.

[0010] Preferably, the bridge arm control circuit comprises four power switch tubes, two power diodes and a high-voltage relay.

[0011] The four power switch tubes are connected in series, the power diodes are connected in series, the series branch is connected in parallel with the two power switch tubes located in the middle, one end of the connection point of the two power switch tubes located in the middle is connected to one end of the normally open contact of the high-voltage relay, and the other end of the normally open contact of the high-voltage relay is connected to the electrode.

[0012] Preferably, the pulse generator further comprises filter capacitors C1-C2, the filter capacitors C1 and C2 are connected in series, and the series branch is connected in parallel with the cascade branch of the power switch tubes, and the connection point of the filter capacitors C1 and C2 is connected with the connection point of the two power diodes.

[0013] Preferably, the pulse generator comprises four bridge arm control circuits, and the four bridge arm control circuits are respectively:

[0014] The first bridge arm control circuit comprises power switch tubes Q1-Q4, power diodes D1-D2 and a high-voltage relay S1, and the first bridge arm control circuit drives the first electrode.

[0015] The second bridge arm control circuit comprises power switch tubes Q5-Q8, power diodes D3-D4 and a high-voltage relay S2, and the second bridge arm control circuit drives the second electrode.

[0016] The third bridge arm control circuit comprises power switch tubes Q9-Q12, power diodes D5-D6 and a high-voltage relay S3, and the third bridge arm control circuit drives the third electrode.

[0017] The fourth bridge arm control circuit comprises power switch tubes Q13-Q16, power diodes D7-D8 and a high-voltage relay S4, and the fourth bridge arm control circuit drives the fourth electrode.

[0018] The input voltage of the bridge arm control circuit is Udc.

[0019] Preferably, when the first electrode and the third electrode are selected as a pair of spaced-apart electrode pair, the potential of the first electrode and the third electrode is:

[0020] When the power switch tubes Q1 and Q2 of the first bridge arm control circuit are turned on, Q3 and Q4 are turned off,

[0021] When the power switch tubes Q9 and Q10 of the third bridge arm control circuit are turned off, Q11 and Q12 are turned on,

[0022] The voltage on the first electrode is Udc, the voltage on the third electrode is 0, and the potential between the first electrode and the third electrode is +Udc.

[0023] When the power switch tubes Q1 and Q2 of the first bridge arm control circuit are turned off, Q3 and Q4 are turned on,

[0024] When the power switch tubes Q9 and Q10 of the third bridge arm control circuit are turned on, Q11 and Q12 are turned off,

[0025] The voltage on the first electrode is 0, the voltage on the third electrode is Udc, and the potential between the first electrode and the third electrode is -Udc.

[0026] Preferably, when the first electrode and the second electrode are selected as a pair of adjacent electrode pairs, the potential of the first electrode and the second electrode is:

[0027] The power switches Q5 and Q8 of the second bridge arm control circuit remain closed, and Q6 and Q7 remain conductive,

[0028] The voltage on the second electrode is Udc / 2,

[0029] When the power switches Q1 and Q2 of the first bridge arm control circuit are conductive, and Q3 and Q4 are closed,

[0030] The voltage on the first electrode is Udc, and the potential between the first electrode and the second electrode is +Udc / 2;

[0031] When the power switches Q1 and Q2 of the first bridge arm control circuit are closed, and Q3 and Q4 are conductive,

[0032] The voltage on the first electrode is 0, and the potential between the first electrode and the second electrode is -Udc / 2.

[0033] Preferably, the full electrode release pulse energy is realized in a round-robin manner.

[0034] The multi-electrode pulse output control pulse field ablation system provided by the application has the following advantages:

[0035] 1. An independent control bridge arm is used to control a single electrode, each electrode corresponds to a high-voltage relay, the high-voltage relay is in advance attracted, and only the bridge arm power switch is used to control the pulse output, so that the response time is fast;

[0036] 2. When switching between the spaced electrodes and the adjacent electrodes, the bus voltage does not need to be charged and discharged, and the response is fast;

[0037] 3. In the same time period, only one electrode pair outputs pulse energy, the power supply power requirement of the high-voltage power supply is relatively low, and the catheter electrode heating is low;

[0038] 4. The electrode pair can be arbitrarily selected, and the flexibility is high;

[0039] 5. Four power switches are used in series to realize driving, and low-voltage power tubes can be used to realize high-voltage output. BRIEF DESCRIPTION OF DRAWINGS

[0040] Figure 1 is a circuit structure schematic diagram of the pulse generator described in the application;

[0041] Figure 2 is a pulse voltage waveform diagram of the application example 2 using spaced electrodes;

[0042] Figure 3 is a pulse voltage waveform diagram of the embodiment 2 of the present application using adjacent electrodes. DETAILED DESCRIPTION

[0043] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the protection scope of the present application.

[0044] It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict.

[0045] The present application will be further described below with reference to the drawings and specific embodiments, but is not limited to the present application.

[0046] Embodiment 1:

[0047] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the protection scope of the present application. Figure 1 The present application will be further described below with reference to the drawings and specific embodiments, but is not limited to the present application.

[0048] Further, the bridge arm control circuit comprises four power switch tubes, two power diodes and a high-voltage relay.

[0049] The four power switch tubes are sequentially cascaded, the power diodes are connected in series, and the series branch is connected in parallel with the two power switch tubes located in the middle. The connection point of the two power switch tubes located in the middle is connected to one end of the normally open contact of the high-voltage relay, and the other end of the normally open contact of the high-voltage relay is connected to the electrode.

[0050] Further, the pulse generator further comprises filter capacitors C1-C2, the filter capacitors C1 and C2 are connected in series, and the series branch is connected in parallel with the cascaded branch of the power switch tube. The connection point of the filter capacitors C1 and C2 is connected to the connection point of the two power diodes.

[0051] In the present embodiment, four power switch tubes are used in a single bridge arm to generate a pulse waveform on the corresponding electrode through the control of the four power switch tubes. Each electrode has an independent bridge arm control circuit, and any electrode pair can be selected for pulse energy output in control.

[0052] Embodiment 2:

[0053] The present embodiment will be described below Figures 1-3 The present embodiment is a pulse field ablation system with multi-electrode pulse output control. The pulse generator includes four bridge arm control circuits, each of which is:

[0054] The first bridge arm control circuit includes power switches Q1-Q4, power diodes D1-D2, and a high-voltage relay S1. The first bridge arm control circuit drives the first electrode.

[0055] The second bridge arm control circuit includes power switches Q5-Q8, power diodes D3-D4, and a high-voltage relay S2. The second bridge arm control circuit drives the second electrode.

[0056] The third bridge arm control circuit includes power switches Q9-Q12, power diodes D5-D6, and a high-voltage relay S3. The third bridge arm control circuit drives the third electrode.

[0057] The fourth bridge arm control circuit includes power switches Q13-Q16, power diodes D7-D8, and a high-voltage relay S4. The fourth bridge arm control circuit drives the fourth electrode.

[0058] The input voltage of the bridge arm control circuit is Udc. As Figure 1 shown.

[0059] Further, when the first electrode and the third electrode are selected as a pair of spaced electrodes, the potential of the first electrode and the third electrode is:

[0060] When the power switches Q1 and Q2 of the first bridge arm control circuit are turned on, Q3 and Q4 are turned off,

[0061] When the power switches Q9 and Q10 of the third bridge arm control circuit are turned on, Q11 and Q12 are turned off,

[0062] The voltage on the first electrode is Udc, the voltage on the third electrode is 0, and the potential between the first electrode and the third electrode is +Udc.

[0063] When the power switches Q1 and Q2 of the first bridge arm control circuit are turned off, Q3 and Q4 are turned on,

[0064] When the power switches Q9 and Q10 of the third bridge arm control circuit are turned on, Q11 and Q12 are turned off,

[0065] The voltage on the first electrode is 0, the voltage on the third electrode is Udc, and the potential between the first electrode and the third electrode is -Udc.

[0066] The waveform diagram is as Figure 2 shown.

[0067] Further, when the first electrode and the second electrode are selected as a pair of adjacent electrode pairs, the potential of the first electrode and the second electrode is:

[0068] The power switch tubes Q5 and Q8 of the second bridge arm control circuit are kept closed, and Q6 and Q7 are kept on,

[0069] The voltage on the second electrode is Udc / 2,

[0070] When the power switch tubes Q1 and Q2 of the first bridge arm control circuit are on, and Q3 and Q4 are off,

[0071] The voltage on the first electrode is Udc, and the potential between the first electrode and the second electrode is +Udc / 2;

[0072] When the power switch tubes Q1 and Q2 of the first bridge arm control circuit are off, and Q3 and Q4 are on,

[0073] The voltage on the first electrode is 0, and the potential between the first electrode and the second electrode is -Udc / 2.

[0074] The waveform diagram is shown in Figure 3 .

[0075] In the embodiment, when the first electrode and the second electrode are selected as a pair of adjacent electrode pairs, the control mode similar to that when the first electrode and the third electrode are selected can be adopted to generate a pulse voltage with the parameters alternately positive and negative between the first electrode and the second electrode by adjusting the value of the bus voltage Udc. The above control mode can also be adopted.

[0076] Further, the pulse energy of all the electrodes can be released by adopting a round-robin mode.

[0077] In the present application, since each electrode is controlled by an independent bridge arm, when the pulse energy of all the electrodes is released, a round-robin mode can be adopted, for example, the first electrode and the third electrode, the second electrode and the fourth electrode, the first electrode and the third electrode, the second electrode and the fourth electrode, and so on. By adopting the round-robin working mode, the response time is faster, and the problem of electrode heating can be effectively controlled.

[0078] Although the present application is described herein with reference to particular embodiments, it is to be understood that these examples are merely hypothetical illustrations of the principles and application of the present application. Therefore, it should be understood that numerous modifications can be made to the exemplary embodiments, and that other arrangements can be devised without departing from the spirit and scope of the present application as defined by the appended claims. It should be understood that features described in connection with separate embodiments can be used in combination with features described in connection with other embodiments. It should also be understood that features described in connection with a particular embodiment can be used in other embodiments described herein.

Claims

1. A pulse field ablation system with multi-electrode pulse output control, characterized in that, It includes: a pulse generator and a pulse ablation catheter. The pulse generator includes multiple parallel-connected bridge arm control circuits and electrodes corresponding to each bridge arm control circuit. The bridge arm control circuits are used to drive the corresponding electrodes. The potential of the bipolar electrodes is applied to the pulse ablation catheter. The bridge arm control circuit includes four power switching transistors, two power diodes, and a high-voltage relay; Four power switching transistors are cascaded in sequence, and power diodes are connected in series. The series branch is connected in parallel with the two power switching transistors in the middle. The connection point of the two power switching transistors in the middle is connected to one end of the normally open contact of the high-voltage relay, and the other end of the normally open contact of the high-voltage relay is connected to the electrode.

2. The pulse field ablation system with multi-electrode pulse output control according to claim 1, characterized in that, The pulse generator also includes filter capacitors C1 to C2, which are connected in series and the series branch is connected in parallel with the cascaded branch of the power switch. The connection point of the filter capacitors C1 and C2 is connected to the connection point of the two power diodes.

3. The pulse field ablation system with multi-electrode pulse output control according to claim 1, characterized in that, The pulse generator includes a four-way bridge arm control circuit, which are as follows: The first bridge arm control circuit includes power switching transistors Q1 to Q4, power diodes D1 to D2 and high-voltage relay S1. The first bridge arm control circuit drives the first electrode. The second bridge arm control circuit includes power switching transistors Q5 to Q8, power diodes D3 to D4, and a high-voltage relay S2. The second bridge arm control circuit drives the second electrode. The third bridge arm control circuit includes power switching transistors Q9 to Q12, power diodes D5 to D6 and high-voltage relay S3. The third bridge arm control circuit drives the third electrode. The fourth bridge arm control circuit includes power switching transistors Q13 to Q16, power diodes D7 to D8, and a high-voltage relay S4. The fourth bridge arm control circuit drives the fourth electrode. The input voltage of the bridge arm control circuit is Udc.

4. The pulse field ablation system with multi-electrode pulse output control according to claim 3, characterized in that, When the first electrode and the third electrode are selected as a pair of separated electrodes, the potentials of the first electrode and the third electrode are: When the power switches Q1 and Q2 of the first bridge arm control circuit are turned on, Q3 and Q4 are turned off. When the power switches Q9 and Q10 of the third bridge arm control circuit are off, and Q11 and Q12 are on, The voltage on the first electrode is Udc, the voltage on the third electrode is 0, and the potential between the first electrode and the third electrode is +Udc. When the power switches Q1 and Q2 of the first bridge arm control circuit are turned off, Q3 and Q4 are turned on. When the power switches Q9 and Q10 of the third bridge arm control circuit are turned on, and Q11 and Q12 are turned off... The voltage on the first electrode is 0, the voltage on the third electrode is Udc, and the potential between the first and third electrodes is -Udc.

5. The pulse field ablation system with multi-electrode pulse output control according to claim 3, characterized in that, When the first electrode and the second electrode are selected as an adjacent electrode pair, the potentials of the first electrode and the second electrode are: In the second bridge arm control circuit, power switches Q5 and Q8 remain off, while Q6 and Q7 remain on. The voltage on the second electrode is Udc / 2. When the power switches Q1 and Q2 of the first bridge arm control circuit are turned on, and Q3 and Q4 are turned off, The voltage on the first electrode is Udc, and the potential between the first electrode and the second electrode is +Udc / 2. When the power switches Q1 and Q2 of the first bridge arm control circuit are turned off, and Q3 and Q4 are turned on, The voltage on the first electrode is 0, and the potential between the first and second electrodes is -Udc / 2.

6. A pulse field ablation system with multi-electrode pulse output control according to any one of claims 1-5, characterized in that, The pulse energy is released across all electrodes using a polling method.

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