Nocardiopsis, compound nocardiopsis, and preparation method and application thereof
By extracting phenofuran from Noccaria ZHD001, the toxic side effects of statins are solved, and a safe and effective blood lipid-lowering drug is provided, which significantly inhibits lipid accumulation in HepG2 cells and reduces blood lipid levels.
CN115584330BActive Publication Date: 2025-08-26ZHEJIANG OCEAN UNIV
Patent Information
- Application Number
- CN202210818662.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-07-12
- Publication Date
- 2025-08-26
- Estimated Expiration
- 2042-07-12
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Abstract
The present invention relates to the field of natural medicine and pharmaceutical technology, and discloses a new compound, novofuran, prepared from Nocardia spp., as well as its preparation method and application. The present invention isolated Nocardia spp. ZHD001 for the first time from sediments collected from the sea area surrounding Zhoushan, and further isolated and studied the fermentation product of Nocardia spp. ZHD001 to obtain novofuran. The present invention determined the chemical structure of the new compound novofuran by analyzing high-resolution mass spectrometry (HRESIMS), hydrogen spectrum, carbon spectrum, HMQC spectrum, HMBC spectrum, and COSY spectrum data of novofuran. A series of studies have shown that novofuran can significantly reduce lipid accumulation in a HepG2 cell lipid model, exhibits lipid-lowering biological activity, and can be used to prepare lipid-lowering drugs or lipid-lowering health foods, showing excellent development and application prospects.
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Citation Information
Patent Citations
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