No-rinse germicidal cleaning agent composition

Abstract

The present invention provides a wash-free disinfectant cleaning agent composition, which contains (A) a quaternary ammonium compound, (B) at least one polymer selected from carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers, and (C) at least one surfactant selected from amphoteric surfactants and semi-polar surfactants, and (D) a monohydric alcohol having 1 to 3 carbon atoms in an amount of less than 10% by mass.

Description

Technical Field

[0001] The present invention relates to a disposable germicidal cleaning composition. Background Art

[0002] Conventionally, there has been a demand for a leave-on disinfectant cleanser composition such as a disinfectant cleanser for fingers to have a bactericidal effect, low irritation to the skin, and excellent storage stability.

[0003] As the finger disinfection cleanser described above, ethanol preparations are often used (see, for example, Patent Document 1). However, ethanol has problems such as the odor and stimulation of alcohol during use and the roughness of the hand skin after use.

[0004] In addition, in order to improve the usability and operability of the disinfectant, a gel finger disinfectant containing an anionic polymer mainly composed of a carboxyvinyl polymer has been proposed (see Patent Document 2). However, the combination of the anionic polymer and the disinfectant containing a non-alcoholic quaternary ammonium compound as a disinfectant component has the problem of reduced bactericidal effect.

[0005] Therefore, there is no wash-free disinfectant cleanser composition that has excellent bactericidal power, causes little irritation to the hand skin during use, has good spreadability of the preparation during application, leaves a refreshing feeling on the hand skin after application, has excellent dispersibility of the preparation, and has low low-temperature storage stability, and the current situation is that there is a strong demand for its rapid development.

[0006] Prior art literature

[0007] Patent Literature

[0008] Patent Document 1: Japanese Patent Application Publication No. 2011-153089

[0009] Patent Document 2: Japanese Patent Application Publication No. 2011-144146 Summary of the invention

[0010] Problems to be solved by the invention

[0011] The present invention aims to solve the above-mentioned problems and achieve the following objectives. That is, the present invention aims to provide a wash-free disinfectant cleanser composition having excellent bactericidal power, low irritation to the hand skin during use, easy spreadability of the preparation during application, refreshing feeling of the hand skin after application, excellent dispersibility of the preparation, and low-temperature storage stability.

[0012] Means of solving problems

[0013] The present inventors have conducted intensive studies to achieve the above-mentioned object and have found that, by containing (A) a quaternary ammonium compound, (B) at least one polymer selected from carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers, and (C) at least one surfactant selected from amphoteric surfactants and semi-polar surfactants, and controlling the content of (D) a monohydric alcohol having 1 to 3 carbon atoms to less than 10% by mass, a wash-free disinfectant cleanser composition can be prepared which has excellent bactericidal power, causes little irritation to the hand skin during use, has easy ductility of the preparation during application, feels refreshing on the hand skin after application, has excellent dispersibility of the preparation, and is excellent in low-temperature storage stability, thereby completing the present invention.

[0014] The present invention is invented based on the above-mentioned knowledge found by the present inventors, and means for solving the above-mentioned problems are as follows. That is,

[0015] <1> A wash-free disinfectant cleaning composition, characterized in that it contains (A) a quaternary ammonium compound, (B) at least one polymer selected from carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers, and (C) at least one surfactant selected from amphoteric surfactants and semi-polar surfactants, and (D) the content of a monohydric alcohol having 1 to 3 carbon atoms is less than 10% by mass.

[0016] <2> according to <1> In the wash-free disinfectant cleaning composition, the mass ratio [(A+B) / C] of the sum of the content (mass %) of component (A) and the content (mass %) of component (B) to the content (mass %) of component (C) is 1 to 1.5.

[0017] <3> according to <1> or <2> The wash-free disinfectant cleaning composition comprises component (A) in an amount of 0.01% to 0.2% by mass, component (B) in an amount of 0.1% to 0.5% by mass, and component (C) in an amount of 0.1% to 0.4% by mass.

[0018] <4> according to <1> ~ <3> In any one of the wash-free disinfectant cleaning compositions, component (A) is a quaternary ammonium compound represented by the following general formula (1),

[0019] [Chemistry 1]

[0020]

[0021] (In the general formula (1), R represents a linear or branched alkyl or alkenyl group having 8 to 18 carbon atoms, and X represents any one selected from a halogen atom, an alkylsulfate having 3 or less carbon atoms, and a dialkylsulfate having 3 or less carbon atoms.)

[0022] The content of the quaternary ammonium compound represented by the general formula (1) wherein R is a linear or branched alkyl or alkenyl group having 12 carbon atoms is less than 80% by mass based on the total amount of the quaternary ammonium compound represented by the general formula (1).

[0023] <5> according to <1> ~ <4> The disposable germicidal cleaning composition described above does not include a germicidal cleaning composition containing 3-iodo-2-propynyl butyl carbamate.

[0024] Effects of the Invention

[0025] According to the present invention, the above-mentioned various problems in the past can be solved, the above-mentioned objects can be achieved, and a wash-free disinfectant cleanser composition can be provided which has excellent bactericidal power, causes little irritation to the hand skin during use, has easy ductility of the preparation during application, has a refreshing feeling on the hand skin after application, has excellent dispersibility of the preparation, and has excellent low-temperature storage stability. DETAILED DESCRIPTION

[0026] (No-rinse germicidal cleaning agent composition)

[0027] The wash-free disinfectant cleaning composition of the present invention contains (A) a quaternary ammonium compound, (B) at least one polymer selected from carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers, and (C) at least one surfactant selected from amphoteric surfactants and semi-polar surfactants, and further contains other components as needed.

[0028] The wash-free disinfectant cleaning composition of the present invention may contain (D) a monohydric alcohol having 1 to 3 carbon atoms, and the content thereof may be less than 10% by mass.

[0029] <(A) Quaternary Ammonium Compound>

[0030] The quaternary ammonium compound as the component (A) is contained mainly to enhance the bactericidal power.

[0031] The quaternary ammonium compound of the component (A) is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include benzethonium chloride, cetylpyridinium chloride, and a compound represented by the following general formula (1). These may be used alone or in combination of two or more.

[0032] [Chemistry 1]

[0033]

[0034] (In the general formula (1), R represents a linear or branched alkyl or alkenyl group having 8 to 18 carbon atoms, and X represents any one selected from a halogen atom, an alkylsulfate having 3 or less carbon atoms, and a dialkylsulfate having 3 or less carbon atoms.)

[0035] When the quaternary ammonium compound of the component (A) includes a compound represented by the general formula (1), the content of the quaternary ammonium compound which is a straight-chain or branched alkyl or alkenyl group in which R has 12 carbon atoms in the general formula (1) is not particularly limited relative to the total amount of the quaternary ammonium compounds represented by the general formula (1), and can be appropriately selected according to the purpose, and is preferably less than 80% by mass, and more preferably less than 70% by mass.

[0036] Examples of the compound represented by the general formula (1) include benzalkonium chloride and the like.

[0037] Among them, the quaternary ammonium compound of the component (A) is preferably benzalkonium chloride or benzethonium chloride from the viewpoint of bactericidal activity.

[0038] The quaternary ammonium compound of the component (A) may be a suitably synthesized compound or a commercially available product.

[0039] Examples of commercially available products of the quaternary ammonium compound of the component (A) include CATION G-50 (manufactured by Sanyo Chemical Industries, Ltd.), NIKKOL CA-101 (manufactured by Nikko Chemical Co., Ltd.), and NISSANCATION (registered trademark) M 2 -100R (manufactured by NOF Corporation), NISSANCATION (registered trademark) F 2 -50R (manufactured by NOF Corporation), etc. In addition, NISSANCATION (registered trademark) F 2 -50R (manufactured by NOF Corporation) is a product in which the content of the quaternary ammonium compound represented by the general formula (1) in which R is a linear alkyl group having 12 carbon atoms is less than 80% by mass relative to the total amount of the quaternary ammonium compound represented by the general formula (1).

[0040] Examples of commercially available products of benzethonium chloride as the quaternary ammonium compound of the component (A) include Lonzagard benzethonium chloride (manufactured by Mitsubishi Chemical Foods Co., Ltd.) and Benzethonium Chloride (manufactured by Tokyo Chemical Industry Co., Ltd.).

[0041] Examples of commercially available products of cetylpyridinium chloride as the quaternary ammonium compound of the component (A) include cetylpyridinium chloride (CPC) (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.).

[0042] The content of the quaternary ammonium compound as the component (A) is not particularly limited and can be appropriately selected according to the purpose. As its lower limit, for example, 0.005 mass % or more, 0.01 mass % or more, etc. can be cited relative to the total amount of the wash-free disinfection cleaning agent composition. In addition, as its upper limit, for example, 0.5 mass % or less, 0.2 mass % or less can be cited. However, from the perspective of bactericidal power and irritation to the skin of the hands, it is preferably 0.005 mass % to 0.5 mass %, more preferably 0.01 mass % to 0.2 mass % relative to the total amount of the wash-free disinfection cleaning agent composition. When the content of the quaternary ammonium compound of the component (A) is 0.005 mass % or more, the bactericidal power is good, and in terms of low irritation to the skin of the hands, it is preferably 0.5 mass % or less.

[0043] <(B) at least one polymer selected from carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers>

[0044] The polymer as the component (B) is contained mainly to improve the ductility of the preparation during coating.

[0045] The polymer of the component (B) is at least one selected from the group consisting of a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer. From the viewpoint of the ductility of the preparation during coating, a carboxyvinyl polymer is preferred.

[0046] As the polymer of the component (B), a polymer synthesized appropriately may be used, or a commercially available product may be used.

[0047] Commercially available products of the carboxyvinyl polymer as the component (B) include, for example, trade names such as Carbopol (registered trademark) 981 (manufactured by The Lubrizol Corporation of Japan), Carbopol (registered trademark) ETD2050 (manufactured by The Lubrizol Corporation of Japan), Carbopol (registered trademark) 980 (manufactured by The Lubrizol Corporation of Japan), and Carbopol (registered trademark) Ultrez 10 (manufactured by The Lubrizol Corporation of Japan).

[0048] Examples of commercially available products of the alkyl-modified carboxyvinyl polymer as the component (B) include Carbopol (registered trademark) 1382 (manufactured by Nippon Lubrizol Co., Ltd.) and Carbopol (registered trademark) ETD2020 (manufactured by Nippon Lubrizol Co., Ltd.).

[0049] The content of the polymer as the component (B) is not particularly limited and can be appropriately selected according to the purpose. As its lower limit, for example, 0.05% by mass or more, 0.1% by mass or more, etc. can be cited relative to the total amount of the wash-free disinfectant cleanser composition. In addition, as its upper limit, for example, 1% by mass or less, 0.5% by mass or less can be cited. However, from the perspective of the easy spread of the preparation during application and the refreshing feeling of the hand skin after application, it is preferably 0.05% by mass to 1% by mass, and more preferably 0.1% by mass to 0.5% by mass relative to the total amount of the wash-free disinfectant cleanser composition. When the content of the polymer of the component (B) is 0.05% by mass or more, the easy spread of the preparation during application is good, and when it is 1% by mass or less, the refreshing feeling of the hand skin after application is good.

[0050] <(C) At least one surfactant selected from amphoteric surfactants and semi-polar surfactants>

[0051] The surfactant as the component (C) is contained mainly for the purpose of improving the bactericidal power and the low-temperature storage stability.

[0052] The surfactant of the component (C) is at least one selected from amphoteric surfactants and semi-polar surfactants.

[0053] -Amphoteric surfactants-

[0054] There are no particular limitations on the amphoteric surfactant, and it can be appropriately selected according to the purpose, and examples thereof include alkyl betaine type amphoteric surfactants, amide betaine type amphoteric surfactants, sulfobetaine type amphoteric surfactants, imidazoline type amphoteric surfactants, etc. These can be used alone or in combination of two or more.

[0055] There are no particular limitations on the alkyl betaine type amphoteric surfactants, which can be appropriately selected according to the purpose, and examples thereof include lauryl dimethylaminoacetic acid betaine, coconut oil alkyl betaine, stearyl dimethylaminoacetic acid betaine, etc. These can be used alone or in combination of two or more.

[0056] The amidobetaine type amphoteric surfactant is not particularly limited and can be appropriately selected according to the purpose, and examples thereof include lauryl amide propyl betaine, coconut oil fatty acid amidopropyl betaine, palm kernel oil fatty acid amidopropyl betaine, etc. These may be used alone or in combination of two or more.

[0057] The sulfobetaine-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the intended purpose, and examples thereof include lauryl hydroxysulfobetaine, laurylamidopropyl hydroxysulfobetaine, etc. These may be used alone or in combination of two or more.

[0058] The imidazoline type amphoteric surfactant is not particularly limited and can be appropriately selected according to the purpose. Examples thereof include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, sodium N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine, sodium N-coconut fatty acid acyl-N'-carboxyethyl-N'-hydroxyethylethylenediamine, and the like.

[0059] -Semi-polar surfactants-

[0060] The semi-polar surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include alkyl dimethyl amine oxides.

[0061] There is no particular limitation on the alkyl dimethyl amine oxide, and it can be appropriately selected according to the purpose, and examples thereof include lauryl dimethyl amine oxide, coconut oil alkyl dimethyl amine oxide, myristyl dimethyl amine oxide, lauramide propyl dimethyl amine oxide, etc. These can be used alone or in combination of two or more.

[0062] Among them, the surfactant of the component (C) is preferably lauryl dimethylamine oxide from the viewpoint of bactericidal activity and low-temperature storage stability.

[0063] As the surfactant of the component (C), a suitably synthesized one may be used, or a commercially available one may be used.

[0064] Examples of commercially available products of the alkyl betaine type amphoteric surfactant as the amphoteric surfactant of the component (C) include Nissan Anon (registered trademark) BL (lauryl dimethylaminoacetic acid betaine, manufactured by NOF Corporation), Nissan Anon (registered trademark) BF (coconut oil dimethylaminoacetic acid betaine, manufactured by NOF Corporation), NIKKOLAM-301 (lauryl dimethylaminoacetic acid betaine, manufactured by Nikko Chemical Co., Ltd.), Amogen S (lauryl betaine, manufactured by Daiichi Kogyo Seiyaku Co., Ltd.), Obazoline LB (lauryl dimethylaminoacetic acid betaine, manufactured by Toho Chemical Industry Co., Ltd.), Rikabion A-100 (lauryl dimethylaminoacetic acid betaine liquid, manufactured by Shin Nippon Rika Co., Ltd.), Amphitol 20BS (lauryl dimethylaminoacetic acid betaine, manufactured by Kao Corporation), Amphitol 24B (lauryl dimethylaminoacetic acid betaine, manufactured by Kao Corporation), Amphitol 86B (stearyl dimethylaminoacetic acid betaine, manufactured by Kao Corporation), Rikabion A-700 (stearyl betaine, manufactured by Shin Nippon Rika Co., Ltd.), etc.

[0065] Examples of commercially available products of the amidobetaine type amphoteric surfactant as the amphoteric surfactant of the component (C) include NIKKOL AM-3130N (coconut fatty acid amidopropyl betaine liquid, manufactured by Nikko Chemical Co., Ltd.), Nissan Anon (registered trademark) BDL-SF (laurylamide propyl dimethylaminoacetic acid betaine, manufactured by NOF Corporation), Nissan Anon (registered trademark) BDF-SF (coconut fatty acid amidopropyl dimethylaminoacetic acid betaine, manufactured by NOF Corporation), Nissan Anon (registered trademark) BDC-SF (palm kernel fatty acid amidopropyl dimethylaminoacetic acid betaine, manufactured by NOF Corporation), Amphitol 20AB (laurylamide propyl betaine liquid, manufactured by Kao Corporation), Amphitol 55AB (coconut oil fatty acid amidopropyl betaine liquid, manufactured by Kao Corporation), Softazolin CPB (coconut oil fatty acid amidopropyl betaine liquid, manufactured by Kawaken Fine Chemicals Co., Ltd.), Softazoline LPB (laurylamide propyl betaine, manufactured by Kawaken Fine Chemicals Co., Ltd.), Softazolin PKPB (palm kernel oil fatty acid amidopropyl betaine liquid, manufactured by Kawaken Fine Chemicals Co., Ltd.), etc.

[0066] Examples of commercially available sulfobetaine-type amphoteric surfactants as the amphoteric surfactant of the component (C) include Amphitol 20HD (lauryl hydroxysulfobetaine liquid, manufactured by Kao Corporation) and Softazolin LSB (laurylamidopropyl hydroxysulfobetaine, manufactured by Kawaken Fine Chemicals Co., Ltd.).

[0067] Examples of commercially available products of the amphoteric surfactant of the component (C) that is an imidazoline-type amphoteric surfactant include NIKKOL AM-101 (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Nikko Chemical Co., Ltd.), Nissan Anon (registered trademark) GLM-R-LV (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by NOF Corporation), Amphitol 20Y-B (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Kao Corporation), Softazolin CH (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Kawaken Fine Chemicals Co., Ltd.), Softazolin CL (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Kawaken Fine Chemicals Co., Ltd.), Softazolin LHL (N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium liquid, manufactured by Kawaken Fine Chemicals Co., Ltd.), softazolin SFD (N-coconut fatty acid acyl-N'-carboxyethyl-N'-hydroxyethylethylenediamine sodium, manufactured by Kawaken Fine Chemicals Co., Ltd.), and the like.

[0068] Examples of commercially available products of the semi-polar surfactant alkyl dimethyl amine oxide as the component (C) include Amphitol 20N (lauryl dimethyl amine oxide liquid, manufactured by Kao Corporation), Softazoline LAO (lauryl amide propyl dimethyl amine oxide liquid, manufactured by Kawaken Fine Chemicals Co., Ltd.), AX Agent S (lauryl dimethyl amine oxide, manufactured by Lion Specialty Chemicals Co., Ltd.), CADENAX DMC-W (coconut oil alkyl dimethyl amine oxide liquid, manufactured by Lion Specialty Chemicals Co., Ltd.), CADENAX DM14D-N (myristic dimethyl amine oxide, manufactured by Lion Specialty Chemicals Co., Ltd.), and CADENAX APA-12W (lauryl dimethyl amine oxide, manufactured by Lion Specialty Chemicals Co., Ltd.).

[0069] The content of the surfactant as the component (C) is not particularly limited and can be appropriately selected according to the purpose. As its lower limit, for example, 0.05% by mass or more, 0.1% by mass or more, etc. can be cited relative to the total amount of the wash-free disinfectant cleanser composition. In addition, as its upper limit, for example, 1% by mass or less, 0.4% by mass or less can be cited. However, from the aspects of bactericidal power, low-temperature storage stability, refreshing feeling of the hand skin after application, and dispersibility of the preparation, it is preferably 0.05% by mass to 1% by mass, and more preferably 0.1% by mass to 0.4% by mass relative to the total amount of the wash-free disinfectant cleanser composition. When the content of the surfactant of the component (C) is 0.05% by mass or more, the bactericidal power, low-temperature storage stability, and dispersibility of the preparation are good, and when it is 1% by mass or less, the refreshing feeling of the hand skin after application is good.

[0070] <Mass ratio [(A+B) / C]>

[0071] The mass ratio [(A+B) / C] of the sum of the content (mass %) of the component (A) and the content (mass %) of the component (B) to the content (mass %) of the component (C) is not particularly limited and can be appropriately selected according to the purpose. As its lower limit, for example, it can be 0.1 or more, 1 or more, etc., and as its upper limit, for example, it can be 10 or less, 5 or less, 1.5 or less, etc., but from the aspects of bactericidal power and dispersibility of the preparation, it is preferably 0.1 to 10, more preferably 1 to 5, and particularly preferably 1 to 1.5. When the mass ratio [(A+B) / C] is 0.1 or more, the bactericidal power is good, and when it is 10 or less, the dispersibility of the preparation is good.

[0072] <(D) Monohydric alcohol having 1 to 3 carbon atoms>

[0073] The wash-free disinfectant cleanser composition may contain a monohydric alcohol having 1 to 3 carbon atoms as the component (D).

[0074] The monohydric alcohol having 1 to 3 carbon atoms as the component (D) is not particularly limited and may be appropriately selected depending on the intended purpose, and examples thereof include ethanol and isopropyl alcohol, etc. These may be used alone or in combination of two or more.

[0075] As the monohydric alcohol having 1 to 3 carbon atoms of the component (D), an appropriately synthesized alcohol may be used, or a commercially available product may be used.

[0076] Examples of commercially available products of the monohydric alcohol having 1 to 3 carbon atoms as the component (D) include 95 degree synthetic specific alcohol (ethanol, manufactured by Shinwa Alcohol Sangyo Co., Ltd.) and isopropyl alcohol (manufactured by Godo Solution Co., Ltd.).

[0077] The content of the monohydric alcohol having 1 to 3 carbon atoms as the component (D) is less than 10% by mass, but preferably 5% by mass or less, and more preferably 0.01% by mass or less, relative to the total amount of the leave-on disinfectant cleanser composition from the perspective of irritation to the hand skin. When the content of the monohydric alcohol having 1 to 3 carbon atoms as the component (D) is 10% by mass or more, the irritation to the hand skin becomes stronger.

[0078] <Other ingredients>

[0079] In the wash-free disinfectant cleaning composition of the present invention, in addition to the components (A), (B), (C) and (D), components commonly used in disinfectant cleaning compositions and the like may be mixed as other components as necessary within the scope not impairing the present invention.

[0080] The other components are not particularly limited and can be appropriately selected according to the purpose, and examples thereof include water, water-soluble polymers other than the component (B), surfactants other than the components (A) and (C), oils, silicones, aromatic alcohols, lanolin derivatives, protein derivatives, chemicals such as vitamins, bactericides other than the components (A) and (D), preservatives, pH adjusters, antioxidants, metal blocking agents, ultraviolet absorbers, animal and plant extracts or derivatives thereof, pigments, fragrances, etc. These can be used alone or in combination of two or more.

[0081] Furthermore, from the viewpoint of irritation to hand skin, the leave-on disinfectant cleanser composition preferably does not contain 3-iodo-2-propynylbutylcarbamate.

[0082] The pH adjuster is not particularly limited and can be appropriately selected according to the purpose, and preferably is an adjuster that can neutralize the component (B), thicken the disposable disinfectant cleaning composition, and adjust the pH of the disposable disinfectant cleaning composition, for example, alkali metal hydroxides, alkanolamines, etc. These can be used alone or in combination of two or more.

[0083] Examples of the alkali metal hydroxide include potassium hydroxide and sodium hydroxide.

[0084] Examples of the alkanolamine include triethanolamine, 2-amino-2-methyl-1-propanol, and diisopropanolamine.

[0085] The content of the other components relative to the total amount of the wash-free disinfecting cleanser composition is not particularly limited, and can be a commonly used content within a range that does not hinder the effects of the present invention.

[0086] In view of the refreshing feeling of the hand skin after application, the total content of the surfactants other than the component (A) is preferably 5% by mass or less, more preferably 3% by mass or less, based on the total amount of the leave-on disinfectant cleanser composition.

[0087] -pH-

[0088] The pH of the wash-free disinfectant cleanser composition is not particularly limited and can be appropriately selected according to the purpose. From the perspectives of bactericidal power, irritation to hand skin, spreadability of the preparation during application, dispersibility of the preparation, and low-temperature storage stability, the pH at 25° C. is preferably 6 to 11, more preferably 7 to 8.

[0089] The pH can be measured, for example, in an environment of 25° C. using a glass electrode type hydrogen ion concentration indicator (device name: pH meter HM-30R type, manufactured by DKK Toa Co., Ltd., electrode type: GST-5721).

[0090] -Manufacturing method-

[0091] There is no particular limitation on the method for producing the disposable disinfectant cleaning agent composition, and it can be appropriately selected according to the purpose. For example, the following method can be cited: Under normal temperature (e.g., 25° C.), the component (B) is added in small amounts in water while stirring to be evenly dispersed. Then, after neutralization by adding a pH adjuster, the component (C) and the component (A) are sequentially mixed while stirring, and after each component is dissolved while stirring, the component (D) and the other components are added and mixed as needed. Afterwards, the pH adjuster is appropriately added while stirring to adjust to a specified pH. In addition, water is preferably added so that the total amount of the disinfectant cleaning agent composition becomes 100% by mass.

[0092] The wash-free disinfectant cleaning composition can be prepared using an apparatus. The apparatus is not particularly limited and can be appropriately selected according to the purpose, and examples thereof include a stirring apparatus having a shearing force and a stirring blade capable of mixing the entire composition.

[0093] The stirring blade is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include a propeller, a turbine, and a disperser.

[0094] -use-

[0095] The use of the disposable disinfectant cleanser composition is not particularly limited and can be appropriately selected according to the purpose, and can be preferably used as a hand skin disinfectant, etc. In addition, the disposable disinfectant cleanser composition can be used on body parts other than hands. Examples of its use include hospitals, nursing homes (nursing facilities), kitchen uses, etc., and it is also suitable for use in the home.

[0096] [Example]

[0097] The present invention is specifically described below with reference to Examples, Comparative Examples and Prescription Examples, but the present invention is not limited to these Examples and Prescription Examples.

[0098] In addition, the contents of each component described in the examples, comparative examples and prescription examples are all values ​​converted to pure components. Among them, for component (D), 95-degree synthetic specific alcohol (manufactured by Shinwa Alcohol Industry Co., Ltd.) was used, and the anhydrous ethanol conversion value (converted to the content (mass %) of anhydrous ethanol) was described.

[0099] (Examples 1 to 20 and Comparative Examples 1 to 4)

[0100] According to the compositions and contents (mass %) shown in Tables 1 to 5 below, the wash-free disinfectant cleanser compositions of Examples 1 to 20 and Comparative Examples 1 to 4 were produced by the following production method.

[0101] -Preparation of a No-rinse Bactericidal Cleanser Composition-

[0102] Under an environment of 25°C, component (B) is added in small amounts while stirring in an appropriate amount of water to uniformly disperse the component and prepare a dispersion. Then, after adding potassium hydroxide to the dispersion for neutralization, component (C) and component (A) are mixed in sequence while stirring, and each component is dissolved while stirring to prepare a solution, and then spices are added for mixing. Here, with respect to Example 15, Example 16 and Comparative Example 4, component (D) is added and mixed at the same time as the spices. Then, potassium hydroxide is appropriately added while stirring the solution to adjust it to a specified pH. Then, water is added to make the entirety of each disinfectant cleaning agent composition 100% by mass, to obtain the wash-free disinfectant cleaning agent compositions of Examples 1 to 20 and Comparative Examples 1 to 4.

[0103] A propeller was used as a stirring blade, and stirring was performed using a three-in-one motor (trade name: HEIDON BL1200, manufactured by Shinto Chemical Co., Ltd.) The pH was measured at 25° C. using a glass electrode type hydrogen ion concentration indicator (device name: pH meter HM-30R type, manufactured by Toa DKK Co., Ltd., electrode type: GST-5721).

[0104] The obtained wash-free disinfectant cleanser compositions of Examples 1 to 20 and Comparative Examples 1 to 4 were evaluated for "bactericidal power", "ease of spread of the preparation during application", "refreshing feeling of the hand skin after application", "dispersibility", "low temperature storage stability" and "irritation to the hand skin" based on the following evaluation methods. The evaluation results are shown in the following Tables 1 to 5.

[0105] <Bactericidal power>

[0106] As the target bacteria, Escherichia coli ( Escherichia coli The bactericidal activity of each of the leave-on disinfectant cleanser compositions of Examples 1 to 20 and Comparative Examples 1 to 4 was evaluated by a quantitative suspension method using NBRC3972: Gram-negative bacteria, obtained from the Japan Independent Administrative Agency Product Evaluation Foundation) and Staphylococcus aureus (NBRC12732: Gram-positive bacteria, obtained from the Japan Independent Administrative Agency Product Evaluation Foundation).

[0107] The Escherichia coli and the Staphylococcus aureus were statically cultured at 37°C for 18 to 24 hours under aerobic conditions using SCDLP agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.). Then, an appropriate amount of the colonies formed on the SCDLP agar medium were scraped and suspended in physiological saline (manufactured by Otsuka Pharmaceutical Co., Ltd.) to a bacterial concentration of 10 8 cfu / mL, as the test bacterial solution. In addition, cfu refers to colony forming unit.

[0108] Next, 0.05 mL of the test bacterial solution was added to 0.45 mL of each of the wash-free disinfectant cleaning compositions of Examples 1 to 20 and Comparative Examples 1 to 4 and mixed. After 30 seconds, the mixed solution was immediately diluted to 10 times with SCDLP liquid culture medium (manufactured by Nippon Pharmaceutical Co., Ltd.) to inactivate it. In addition, the inactivated solution was diluted 100 times, 1,000 times and 10,000 times with SCDLP liquid culture medium, and each 10-fold stage dilution was performed. After that, 0.1 mL of the inactivated solution diluted to each concentration was inoculated (n=3) on SCDLP agar culture medium (manufactured by Nippon Pharmaceutical Co., Ltd., 9 cm culture dish), and the diluted mixed plate culture method was used to culture at 37°C for 24 hours under aerobic conditions. After cultivation, the total number of colonies formed was counted and the number of residual viable bacteria was determined. When no colonies were observed, the number of residual viable bacteria was set to be less than the detection limit of 10 cfu / mL. The "bactericidal power" was scored based on the measured number of residual living bacteria according to the following criteria. The average value of the scores was evaluated based on the following evaluation criteria "bactericidal power".

[0109] - Criteria for judging "bactericidal power" -

[0110] 5 points: The number of residual living bacteria is less than 10 cfu / mL (less than the detection limit)

[0111] 4 points: The number of residual viable bacteria is 10 cfu / mL or more and less than 100 cfu / mL

[0112] 3 points: The number of residual viable bacteria is 100 cfu / mL or more and less than 1,000 cfu / mL

[0113] 2 points: The number of residual viable bacteria is 1,000 cfu / mL or more and less than 10,000 cfu / mL

[0114] 1 point: The number of residual viable bacteria is 10,000 cfu / mL or more

[0115] -Evaluation criteria for "bactericidal power"-

[0116] ◎: The average of the above scores is 4.0 points or more and 5.0 points or less

[0117] ○: The average of the scores is 3.0 or more and less than 4.0

[0118] △: The average of the scores is 2.0 or more and less than 3.0

[0119] ×: The average of the scores is less than 2.0 points

[0120] <Easy Spreadability of the Preparation during Application>

[0121] In an environment of 25°C, 10 professional testers (5 males and 5 females) rubbed 0.5 g of each of the disposable disinfectant cleanser compositions of Examples 1 to 20 and Comparative Examples 1 to 4 on the palm and back of the hand, and scored the good spreadability of the preparations at this time based on the following judgment criteria. The average value of the above scores was used to evaluate the "easy spreadability of the preparations during application" based on the following evaluation criteria.

[0122] - Criteria for judging "the spreadability of the preparation during coating" -

[0123] 5 points: Feels very stretchable

[0124] 4 points: Feels easy to stretch

[0125] 3 points: Feels slightly easier to stretch

[0126] 2 points: Slightly difficult to stretch

[0127] 1 point: Feeling difficult to stretch

[0128] -Evaluation criteria for "Easy spread of the formulation during coating"-

[0129] ◎: The average of the scores is 4.0 or more and less than 5.0

[0130] ○: The average of the scores is 3.0 or more and less than 4.0

[0131] △: The average of the scores is 2.0 or more and less than 3.0

[0132] ×: The average of the scores is less than 2.0 points

[0133] <Refreshing feeling on hand skin after application>

[0134] In an environment of 25°C, 10 professional testers (5 males and 5 females) scored the refreshing feeling of 0.5 g of each of the disposable disinfectant detergent compositions of Examples 1 to 20 and Comparative Examples 1 to 4 applied to the palms and backs of the hands based on the following judgment criteria. The "refreshing feeling of the hand skin after application" was evaluated based on the average of the above scores based on the following evaluation criteria.

[0135] -Judgment criteria for "refreshing feeling of hand skin after application"-

[0136] 5 points: The skin on the hands feels refreshed

[0137] 4 points: Feel the refreshing feeling of the hand skin

[0138] 3 points: The skin on the hands feels slightly refreshed

[0139] 2 points: The hand skin hardly feels refreshed

[0140] 1 point: No refreshing feeling on the hand skin

[0141] -Evaluation criteria for "refreshing feeling of hand skin after application"-

[0142] ◎: The average of the above scores is 4.0 points or more and 5.0 points or less

[0143] ○: The average of the scores is 3.0 or more and less than 4.0

[0144] △: The average of the scores is 2.0 or more and less than 3.0

[0145] ×: The average of the scores is less than 2.0 points

[0146] <Dispersibility>

[0147] For each sample of each of the wash-free disinfectant cleaning agent compositions of Examples 1 to 20 and Comparative Examples 1 to 4, 50 mL was filled in a 50 mL glass screw vial (trade name: SV-50A, manufactured by Nichiden Rika Glass Co., Ltd.), and the appearance was visually observed by a specialized evaluator, and the "dispersibility" of the preparation was scored based on the following judgment criteria. The "dispersibility" was evaluated based on the average value of the scores based on the following evaluation criteria.

[0148] - Criteria for judging “dispersion” -

[0149] 5 points: No condensate was observed at all

[0150] 4 points: Dispersed and almost no agglomerates in the composition, in a uniform state

[0151] 3 points: Dispersed and slight aggregation was observed in the composition, but it was a level that was not problematic

[0152] 2 points: Agglomerates were observed overall

[0153] 1 point: Precipitation of aggregates was observed

[0154] - Evaluation criteria for "dispersion" -

[0155] ◎: The average of the above scores is 4.0 points or more and 5.0 points or less

[0156] ○: The average of the scores is 3.0 or more and less than 4.0

[0157] △: The average of the scores is 2.0 or more and less than 3.0

[0158] ×: The average of the scores is less than 2.0 points

[0159] <Low-temperature storage stability>

[0160] 50 mL of each of the no-rinse disinfectant cleaning agent compositions of Examples 1 to 20 and Comparative Examples 1 to 4 were placed in a 50 mL glass screw bottle (trade name: SV-50A, manufactured by Nippon Rika Glass Co., Ltd.), three bottles of each sample were filled, and after storing in a -5°C constant temperature bath for 1 month, an expert assessor visually observed the appearance of each no-rinse disinfectant cleaning agent composition, and the low-temperature storage stability was scored based on the following criteria, and the "low-temperature storage stability" was evaluated based on the following evaluation criteria.

[0161] - Criteria for judging "low temperature storage stability" -

[0162] 5 points: No condensation was observed

[0163] 4 points: Almost no aggregation was observed

[0164] 3 points: Slight aggregation was observed, but it was not a problem.

[0165] 2 points: Agglomeration was observed overall

[0166] 1 point: Coagulation precipitation was observed

[0167] -Evaluation criteria for "low temperature storage stability"-

[0168] ◎: The average of the above scores is 4.0 points or more and 5.0 points or less

[0169] ○: The average of the scores is 3.0 or more and less than 4.0

[0170] △: The average of the scores is 2.0 or more and less than 3.0

[0171] ×: The average of the scores is less than 2.0 points

[0172] <Irritation to hand skin>

[0173] In an environment of 25°C, 10 professional testers (5 males and 5 females) rubbed 0.5 g of each of the disposable disinfectant detergent compositions of Examples 1 to 20 and Comparative Examples 1 to 4 on the palms and backs of the hands to evaluate the irritation of the hands, and the scores were calculated according to the following judgment criteria. Based on the average of the above scores, the "irritation to the hands" was evaluated based on the following evaluation criteria.

[0174] -Judgment criteria for "irritation to hand skin"-

[0175] 5 points: No irritation to the hand skin

[0176] 4 points: Almost no irritation to the hand skin

[0177] 3 points: Slight irritation to the skin of the hands, but no problem

[0178] 2 points: Feeling of irritation on the skin of the hands

[0179] 1 point: Strong irritation to the skin of the hands

[0180] -Evaluation criteria for "irritation to hand skin"-

[0181] ◎◎: The average of the above scores is 4.5 points or more and 5.0 points or less

[0182] ◎: The average of the scores is 4.0 or more and less than 4.5

[0183] ○: The average of the scores is 3.0 or more and less than 4.0

[0184] △: The average of the scores is 2.0 or more and less than 3.0

[0185] ×: The average of the scores is less than 2.0 points

[0186] [Table 1]

[0187]

[0188] [Table 2]

[0189]

[0190] [Table 3]

[0191]

[0192] [Table 4]

[0193]

[0194] [Table 5]

[0195]

[0196] (Prescription Examples 1 to 10)

[0197] The wash-free disinfectant cleaning agent compositions of Prescription Examples 1 to 10 were prepared according to the compositions and contents (mass %) shown in Tables 6 and 7 below.

[0198] Specifically, in the “-Preparation of a no-rinse disinfectant cleaning composition-” of Examples 1 to 20 and Comparative Examples 1 to 4, component (D) was not added but replaced with fragrance, and common components other than potassium hydroxide and purified water shown in the following Tables 6 and 7 were added. Otherwise, the no-rinse disinfectant cleaning composition of Prescription Examples 1 to 10 was prepared by the same method as in the “-Preparation of a no-rinse disinfectant cleaning composition-” of Examples 1 to 20 and Comparative Examples 1 to 4.

[0199] The prepared no-rinse disinfectant cleanser compositions of Prescription Examples 1 to 10 were evaluated for "bactericidal power", "ease of spread of the preparation during application", "refreshing feeling of the hand skin after application", "dispersibility", "low temperature storage stability" and "irritation to the hand skin" using the same evaluation methods as Examples 1 to 20 and Comparative Examples 1 to 4. The evaluation results are shown in Tables 6 and 7 below.

[0200] [Table 6]

[0201]

[0202] [Table 7]

[0203]

[0204] The raw materials used in the wash-free disinfectant cleanser compositions used in Examples 1 to 20, Comparative Examples 1 to 4, and Prescription Examples 1 to 10 are shown in Table 8 below.

[0205] [Table 8]

[0206]

[0207] Industrial Applicability

[0208] The wash-free disinfectant cleanser composition of the present invention has excellent bactericidal power, low irritation to the hand skin during use, easy ductility of the preparation during application, refreshing feeling of the hand skin after application, excellent dispersibility and low-temperature storage stability of the preparation, and therefore can be preferably used as a hand skin disinfectant, etc. In addition, the wash-free disinfectant cleanser composition can also be used for body parts other than hands. As the place of use, for example, hospitals, sanatoriums, kitchen uses, etc. can be cited, and it is also suitable for use in the home.

Claims

1. A wash-free disinfectant cleaning composition, characterized in that: Containing (A) a quaternary ammonium compound, (B) at least one polymer selected from carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers, and (C) at least one surfactant selected from amphoteric surfactants and semi-polar surfactants, and (D) a monohydric alcohol having 1 to 3 carbon atoms in an amount of less than 10% by mass, The component (A) is at least one selected from a quaternary ammonium compound represented by the following general formula (1), benzethonium chloride, and cetylpyridinium chloride, In the general formula (1), R represents a linear or branched alkyl or alkenyl group having 8 to 18 carbon atoms, and X represents any one selected from a halogen atom, an alkylsulfate having 3 or less carbon atoms, and a dialkylsulfate having 3 or less carbon atoms. The component (C) is selected from at least one of alkyl betaine type amphoteric surfactants and alkyl dimethyl amine oxides, The content of the component (A) is 0.005 mass % to 0.5 mass %, The content of the component (B) is 0.05% by mass to 1% by mass. The content of the component (C) is 0.05% by mass to 1% by mass. The mass ratio of the sum of the content of the component (A) and the content of the component (B) to the content of the component (C) [(A+B) / C] is 0.1 to 10, and the units of the contents of the components (A), (B) and (C) are mass %. The pH at 25°C is 6 or more and 11 or less.

2. The disposable disinfectant cleaning composition according to claim 1, wherein the mass ratio of the sum of the content of component (A) and the content of component (B) to the content of component (C), i.e., (A+B) / C, is 1 to 1.5, and the units of the contents of component (A), component (B) and component (C) are mass %.

3. The wash-free disinfectant cleaning composition according to claim 1 or 2, wherein the content of component (A) is 0.01% to 0.2% by mass, the content of component (B) is 0.1% to 0.5% by mass, and the content of component (C) is 0.1% to 0.4% by mass.

4. The disposable disinfectant cleaning composition according to claim 1 or 2, wherein the component (A) is a quaternary ammonium compound represented by the following general formula (1): in, In the general formula (1), R represents a linear or branched alkyl or alkenyl group having 8 to 18 carbon atoms, and X represents any one selected from a halogen atom, an alkylsulfate having 3 or less carbon atoms, and a dialkylsulfate having 3 or less carbon atoms. The content of the quaternary ammonium compound represented by the general formula (1) wherein R is a linear or branched alkyl or alkenyl group having 12 carbon atoms is less than 80% by mass based on the total amount of the quaternary ammonium compound represented by the general formula (1).

5. The disposable germicidal cleaning composition according to claim 1 or 2, which does not include a germicidal cleaning composition containing 3-iodo-2-propynylbutylcarbamate.

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