Blood purification apparatus and storage medium

Abstract

The application provides a blood purification device and a storage medium. The pressure sensor of the blood purification device measures the liquid pressure of an elongated tube to obtain pressure measurement data. The storage medium stores program instructions executable by a processor. The processor can execute: outputting a replacement fluid to the elongated tube according to a preflush start instruction; calculating a replacement fluid pressure change amount and a replacement fluid pressure change time according to the pressure measurement data; determining a viscosity system parameter according to a preset viscosity of the replacement fluid, the replacement fluid pressure change amount and the replacement fluid pressure change time; performing dialysis on blood through a dialyzer according to a blood treatment instruction, and outputting the dialyzed blood to the elongated tube; calculating a first blood pressure change amount and a first blood pressure change time according to the pressure measurement data; and determining a first blood viscosity according to the viscosity system parameter, the first blood pressure change amount and the first blood pressure change time. The application solves the problem that blood viscosity cannot be detected during hemodialysis treatment.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of blood purification, in particular to a blood purification device and a storage medium. BACKGROUND

[0002] The blood purification device draws the human body blood out of the body, then filters out specific molecular substances in the blood, and then returns the purified blood to the human body, so as to achieve the effect of disease treatment. According to the blood purification principle, the blood purification treatment mode can be divided into hemodialysis, hemofiltration, hemodialysis filtration, hemoperfusion, plasma replacement, immunoadsorption, peritoneal dialysis and other treatment modes. Different blood purification treatment modes are suitable for different clinical symptoms, such as the treatment of various cardiovascular instability, hypercatabolism or acute and chronic renal failure with brain water, multiple organ dysfunction syndrome, acute respiratory distress syndrome, crush syndrome, acute necrotizing pancreatitis, chronic heart failure, hepatic encephalopathy, drug and poison poisoning and other diseases.

[0003] The blood purification treatment needs to rely on the blood purification device to execute. Taking the hemodialysis treatment mode as an example, the blood of the patient and the dialysate with standard ion concentration are introduced into the dialyzer at the same time, the dialysate and the blood are on both sides of the hollow fiber membrane, and the diffusion, convection, ultrafiltration and other effects of the hollow fiber membrane are used to remove the excess water in the patient's body at an appropriate speed, so as to achieve the purpose of correcting the water electrolyte and acid-base balance. In order to ensure the safety of the patient during the hemodialysis treatment process, the blood rheology parameters in the hemodialysis treatment process are monitored in real time, so as to effectively inhibit the complications such as hypertension and severe dehydration caused by blood vessel atrophy in the dialysis process. As one of the blood rheology parameters, blood viscosity is an important indicator reflecting the blood flow property. Normal blood viscosity is an important condition to ensure the normal circulation of extracorporeal blood. When the blood viscosity in the extracorporeal blood circulation process increases, it will cause problems such as blood clotting and thrombosis, and cause cardiovascular-related complications.

[0004] In the prior art, when the blood viscosity of the patient is determined, only the blood routine or blood viscosity of the patient can be tested before or after dialysis, and the test is performed by a viscosity tester and a blood instrument during the test. The blood viscosity of the patient cannot be detected during the hemodialysis treatment process, so the user cannot evaluate the hemodialysis treatment of the patient according to the detected blood viscosity, which not only reduces the practical value and reliability of the blood viscosity determination process, but also reduces the safety of the patient during the hemodialysis treatment. SUMMARY

[0005] The present application aims to solve the problem that the blood viscosity cannot be detected during the hemodialysis treatment in the prior art.

[0006] To solve the above problems, the first aspect of the present application provides a blood purification device, which comprises an elongated tube, a power assembly, a dialyzer, an arterial pipeline connected with a blood input end of the dialyzer, a venous pipeline connected with a blood output end of the dialyzer, a first end of the elongated tube connected with the venous pipeline, a second end of the elongated tube connected with the power assembly, a processor and a memory, wherein the processor is electrically connected with the memory and the pressure sensor through a bus;

[0007] The pressure sensor is used for measuring the liquid pressure of the elongated tube to obtain pressure measurement data.

[0008] The memory stores program instructions executable by the processor, and the processor calling the program instructions can execute the following method.

[0009] According to the preflush starting instruction output by the user, the displacement liquid is output to the arterial pipeline, the dialyzer and the venous pipeline, and is output to the elongated tube through the power assembly.

[0010] According to the pressure measurement data, the displacement liquid pressure change amount of the elongated tube and the displacement liquid pressure change time of the elongated tube are calculated.

[0011] According to the preset viscosity of the displacement liquid, the displacement liquid pressure change amount of the elongated tube and the displacement liquid pressure change time of the elongated tube, the viscosity system parameter is determined.

[0012] According to the blood treatment instruction output by the user, the blood is dialyzed through the dialyzer, and the dialyzed blood is output to the elongated tube through the power assembly.

[0013] According to the pressure measurement data, the first blood pressure change amount of the elongated tube and the first blood pressure change time of the elongated tube are calculated.

[0014] According to the viscosity system parameter, the first blood pressure change amount of the elongated tube and the first blood pressure change time of the elongated tube, the first blood viscosity is determined.

[0015] The second aspect of the present application provides a computer readable storage medium, which stores a computer program, and the computer program is executed by a processor to realize the following method.

[0016] According to the preflush starting instruction output by the user, the displacement liquid is output to the arterial pipeline, the dialyzer and the venous pipeline, and is output to the elongated tube through the power assembly.

[0017] According to the pressure measurement data, the displacement liquid pressure change amount of the elongated tube and the displacement liquid pressure change time of the elongated tube are calculated.

[0018] determine a viscosity system parameter according to the preset displacement liquid viscosity, the displacement liquid pressure variation amount of the elongated tube and the displacement liquid pressure variation time of the elongated tube;

[0019] dialysis blood through the power assembly to the elongated tube according to the blood treatment instruction output by the user;

[0020] calculate the first blood pressure variation amount of the elongated tube and the first blood pressure variation time of the elongated tube according to the pressure measurement data;

[0021] determine the first blood viscosity according to the viscosity system parameter, the first blood pressure variation amount of the elongated tube and the first blood pressure variation time of the elongated tube.

[0022] The blood purification equipment and the computer readable storage medium provided by the application utilize the operation steps in the hemodialysis process, obtain the viscosity system parameter necessary in the viscosity detection process in the preflush stage, so as to provide data basis for the blood viscosity calculation process in the later stage, facilitate the accurate calculation of the blood viscosity of the patient when the patient is hemodialysed, and perfectly combine the blood viscosity detection and the hemodialysis process. The application effectively integrates the viscosity detection into the hemodialysis process, can detect and monitor the blood viscosity of the patient in real time in the blood treatment stage, has strong practicality and convenience. In addition, the application ingeniously utilizes the pressure change with time when the fluid medium is inhaled, so as to determine the blood viscosity method, can effectively obtain the blood viscosity value, has low detection cost, high detection feasibility and high detection reliability, and can detect the blood viscosity in real time in the hemodialysis process, so that the medical staff can refer to the evaluation process of the hemodialysis effect according to the blood viscosity, avoid the occurrence of cardiovascular and other related complications of the patient, and further ensure the safety of the patient in the hemodialysis process, and overcome the problem that the blood viscosity of the patient cannot be detected in the hemodialysis process in the prior art, so that the safety of the hemodialysis treatment of the patient is low. BRIEF DESCRIPTION OF DRAWINGS

[0023] Figure 1 It is a first structure schematic view of the blood purification equipment provided in the embodiment of the application.

[0024] Figure 2 It is a second structure schematic view of the blood purification equipment provided in the embodiment of the application.

[0025] Figure 3 It is a third structure schematic view of the blood purification equipment provided in the embodiment of the application.

[0026] Figure 4A flowchart of a method performed by a processor of a blood purification apparatus provided in an embodiment of the present application is shown in the figure;

[0027] Figure 5 A schematic diagram of a first blood viscosity curve over time provided in an embodiment of the present application is shown in the figure;

[0028] Figure 6 A schematic diagram of a target dehydration amount and a second blood viscosity curve over time provided in an embodiment of the present application is shown in the figure;

[0029] Figure 7 A structural diagram of a display screen of a blood purification apparatus provided in an embodiment of the present application is shown in the figure.

[0030] Legend of reference signs:

[0031] 1 - elongated tube; 2 - power assembly; 3 - dialyzer; 4 - arterial line; 5 - venous line; 6 - pressure sensor; 7 - blood probe; 8 - blood pump; 9 - heparin pump; 10 - first liquid storage bag; 11 - second liquid storage bag; 12 - third liquid storage bag; 13 - filtration pump; 14 - dialysate pump; 15 - replacement fluid pump; 16 - venous jug; 17 - liquid level detector; 18 - pre-replacement; 19 - post-replacement; 20 - first heater; 21 - first flow interruption detector; 22 - liquid leakage detector; 23 - second heater; 24 - second flow interruption detector; 25 - air bubble detector; 26 - display. DETAILED DESCRIPTION

[0032] The technical solutions of the present application and how the technical solutions of the present application solve the above technical problems will be described in detail below with specific embodiments. The following specific embodiments can be combined with each other, and the same or similar concepts or processes can not be described again in some embodiments. The embodiments of the present application will be described below with reference to the accompanying drawings.

[0033] It should be noted that examples of embodiments of the present application are shown in the accompanying drawings, wherein the same or similar reference numerals represent the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present application and cannot be interpreted as a limitation on the present application.

[0034] As will be understood by those familiar with the art, the terms "one," "another," "an," and "the" as used herein can mean "at least one," "one or more," and thus include the plural as well as the singular unless explicitly stated otherwise. The terms "including," "includes," "comprising," "comprises," "containing," "contains," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises, includes, contains the recited elements or a variation thereof can not only include the recited elements, but can also include additional elements not expressly listed or inherent to such process, method, article, or apparatus. The terms "connected" and "coupled" as used herein, broadly refer to any connection or coupling, either direct or indirect, between or among two or more elements. These terms can refer to an electrical connection that is created by the physical contact of those elements. These terms can also refer to a wireless electrical connection that is created by the non-physical contact of those elements. The term "and / or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.

[0035] Referring to Figure 1 and Figure 2 , Figure 1 is a structural schematic diagram of an embodiment of a blood purification device in the present application, Figure 2 is a structural schematic diagram of another embodiment of a blood purification device in the present application. The blood purification device comprises an elongated tube 1, a power assembly 2, a dialyzer 3, an arterial line 4 and a venous line 5, and a pressure sensor 6. The arterial line 4 is connected to a blood input end of the dialyzer 3, the venous line 5 is connected to a blood output end of the dialyzer 3, a first end of the elongated tube 1 is connected to the venous line 5, and a second end of the elongated tube 1 is connected to the power assembly 2. The arterial line 4 outputs blood of a patient to the dialyzer 3, the dialyzer 3 performs hemodialysis on the blood, the venous line 5 returns the blood after hemodialysis to a vein of the human body, the power assembly 2 provides driving force to make the elongated tube 1 access liquid in the venous line, and the power assembly 2 can control a pressure difference between two ends of the elongated tube 1 to control a liquid flow rate and a liquid flow time in the elongated tube 1. The pressure sensor 6 is arranged on the elongated tube 1, and the pressure sensor 6 can measure liquid pressure in the elongated tube 1 to obtain pressure measurement data.

[0036] The blood purification device also includes: a blood detector 7 for detecting the presence of blood in the venous line 5; a blood pump 8 for controlling the operating speed and direction of the blood pump 8, which can change the flow rate and direction of blood in the arterial line 4; a heparin pump 9 for injecting heparin; a first liquid storage bag 10 for storing filtrate; a second liquid storage bag 11 for storing dialysate; a third liquid storage bag 12 for storing replacement fluid; a filtration pump 13 located between one end of the dialyzer 3 and the first liquid storage bag 10; a dialysate pump 14 located between the other end of the dialyzer 3 and the second liquid storage bag 11; and a replacement fluid pump 15 located at the front end of the third liquid storage bag 12. The following components are included: a venous reservoir 16 located between dialyzer 3 and venous tubing 5, and a level detector 17 located on the venous reservoir 16; a pre-displacement 18 and a post-displacement 19 located between arterial tubing 4 and venous reservoir 16; a first heater 20 located between dialyzer 3 and dialysate pump 14, and a first flow interruption detector 21 located between dialysate pump 14 and second liquid storage bag 11; a leak detector 22 located between dialyzer 3 and filtration pump 13; a second heater 23 located between post-displacement 19 and replacement fluid pump 15, and a second flow interruption detector 24 located between replacement fluid pump 15 and third liquid storage bag 12; and a bubble detector 25 located on venous tubing 5.

[0037] To better illustrate the method for detecting blood viscosity using the blood purification device in this application embodiment, the principle of liquid viscosity detection is explained below:

[0038] Viscosity detection principle: Based on Poisson's law in fluid mechanics:

[0039] Q = ΔP × πR 4 / (8μL)

[0040] Where Q represents the flow rate, measured in meters (m). 3 / s, R is the radius of the slender tube 1 in meters, ΔP is the pressure drop at the inlet and outlet of the slender tube 1 in Pa, L is the length of the slender tube 1 in meters, and u is the dynamic viscosity in Pa·s.

[0041] Since the damping generated by the liquid after it is drawn into the slender tube 1 is close to u (viscosity) × t (duration of liquid being drawn in by the injector), the change factor at this time is only linear with the damping, that is, the change value of ΔP1 = ku × t. This formula can be converted to: u = ΔP1 / k × t, where ΔP1 represents the change in liquid pressure in the slender tube 1, t represents the time of change in liquid pressure in the slender tube 1, and k represents the system parameter. Both ΔP1 and t are values ​​that can be measured, and k is only related to the piping structure of the blood purification equipment itself.

[0042] Therefore, in the pre-flushing stage, the k value is determined by using the flow state of the displacement liquid in the elongated tube 1, and then in the blood treatment stage, the viscosity of the blood is calculated by using the flow state of the blood in the elongated tube 1, so that the blood viscosity, a blood hemodynamic parameter, can be detected in real time during the hemodialysis process, to provide a reference for the medical staff to evaluate the hemodialysis effect, and to further ensure the safety and efficiency of the patient in the hemodialysis process.

[0043] Referring to Figure 3 and Figure 4 The blood purification apparatus provided in the embodiments of the present application further includes a processor 301 and a memory 303, the processor 301 is electrically connected with the memory 303 and the pressure sensor 6 through a bus 302, the memory 303 stores program instructions executable by the processor 301, and the processor 301 can execute the following method by calling the program instructions.

[0044] In step S410, the displacement liquid is output to the arterial pipeline 4, the dialyzer 3 and the venous pipeline 5 according to the pre-flushing start instruction output by the user, and is output to the elongated tube 1 by the power assembly 2.

[0045] Before starting the blood purification apparatus, the blood purification apparatus needs to be connected with pipelines, that is, the blood purification apparatus is connected with pipelines according to the structural schematic diagram (for example, as shown in the drawings), and it is ensured that the different components are tightly connected without any connection gap, for example, the first end of the arterial pipeline 4 is connected to the blood input end of the dialyzer 3, the second end of the arterial pipeline 4 is connected to the artery of the patient, and the like, so as to ensure that the blood purification apparatus is in a normal physical connection state. Figure 1

[0046] When the blood purification apparatus is connected with the pipelines, the pre-flushing start instruction can be sent, and the processor is configured to control the blood purification apparatus to enter the pre-flushing stage according to the pre-flushing start instruction. The pre-flushing stage is a necessary step in the operation process of the blood purification apparatus, and after the pre-flushing stage, the residual impurities in the arterial pipeline 4, the dialyzer 3 and the venous pipeline 5 can be prevented from affecting the subsequent blood treatment process. The pre-flushing stage will be described below. Figure 1 In the pre-flushing stage, one end of the arterial pipeline 4 is connected to the third liquid storage bag 12, the third liquid storage bag 12 is used to store the displacement liquid, the other end of the venous pipeline 5 is connected to the waste liquid bag, one end of the arterial pipeline 4 is connected to the displacement liquid, the displacement liquid flows through the arterial pipeline 4, the dialyzer 3 and the venous pipeline 5 in sequence, to flush the pipelines in the blood purification apparatus, the displacement liquid after being flushed becomes waste liquid, and the waste liquid is stored by the waste liquid bag. When the displacement liquid flows in the venous pipeline 5, the driving force is provided by the power assembly 2, the elongated tube 1 sucks the displacement liquid from the venous pipeline 5, that is, the displacement liquid is output to the elongated tube 1 by the power assembly 2. ​

[0047] The elongated tube 1 in the embodiment can be a small-hole elongated tube with a diameter of 1 mm and a length of 200 mm. The small-hole elongated tube can simulate the flow mode of blood in a capillary vessel, so that the pressure sensor 6 can more accurately detect the pressure change of the elongated tube 1, and the phenomenon of liquid waste in the venous line 5 can be avoided.

[0048] In step S420, the replacement fluid pressure change of the elongated tube 1 and the replacement fluid pressure change time of the elongated tube 1 are calculated according to the pressure measurement data.

[0049] When the elongated tube 1 accesses the replacement fluid, the replacement fluid pressure of the elongated tube 1 gradually increases, for example, the replacement fluid pressure change of the elongated tube 1 is 100 mmHg (the positive value of the replacement fluid pressure change represents that the replacement fluid pressure of the elongated tube 1 gradually increases, and the negative value of the replacement fluid pressure change represents that the replacement fluid pressure of the elongated tube 1 gradually decreases). The pressure sensor 6 can measure the replacement fluid pressure of the elongated tube 1 to obtain pressure measurement data, and calculate the replacement fluid pressure change of the elongated tube 1 and the replacement fluid pressure change time of the elongated tube 1 through the pressure measurement data.

[0050] Specifically, as an optional implementation, referring to Figure 1 The pressure sensor 6 can be arranged at the first end of the elongated tube 1, and the replacement fluid pressure change of the elongated tube 1 is calculated according to the pressure measurement data, including:

[0051] If the total amount of the replacement fluid accessed by the elongated tube 1 is greater than or equal to the preset volume, the replacement fluid pressure value of the elongated tube 1 is measured by the pressure sensor 6, and the replacement fluid pressure change of the elongated tube 1 is calculated according to the replacement fluid pressure value of the elongated tube 1 and the pressure value of the elongated tube 1 without accessing the replacement fluid.

[0052] The preset volume is a value set in advance, and the preset volume is related to the diameter of the elongated tube 1 and the length of the elongated tube 1. Those skilled in the art can set it according to the actual situation, for example, the diameter of the elongated tube 1 is 1 mm, and the length of the elongated tube 1 is 200 mm. Therefore, the preset volume can be 200 uL. When it is detected that the total amount of the replacement fluid accessed by the elongated tube 1 is greater than or equal to 200 uL, the replacement fluid pressure value of the elongated tube 1 is measured by the pressure sensor 6.

[0053] The displacement hydraulic pressure change amount = second pressure detection value - first pressure detection value, wherein the first pressure detection value represents the displacement hydraulic pressure value of the elongated tube 1 measured by the pressure sensor 6 when the elongated tube 1 is not connected to the displacement liquid; and the second pressure detection value represents the displacement hydraulic pressure value of the elongated tube 1 measured by the pressure sensor 6 when the total amount of the displacement liquid connected to the elongated tube 1 is greater than or equal to the preset volume. For example, when the displacement hydraulic pressure of the elongated tube 1 measured by the pressure sensor 6 is 10 mmHg when the elongated tube 1 is not connected to the displacement liquid, and the displacement hydraulic pressure of the elongated tube 1 measured by the pressure sensor 6 is 100 mmHg when the displacement liquid is output to the elongated tube 1 by the power assembly 2 and the total amount of the displacement liquid connected to the elongated tube 1 is greater than or equal to 200 uL, then the displacement hydraulic pressure change amount is 100 mmHg - 10 mmHg = 90 mmHg.

[0054] As another optional implementation, referring to Figure 2 , the pressure sensor 6 can also include a first pressure sensor and a second pressure sensor, the first pressure sensor is located at the first end of the elongated tube 1, and the second pressure sensor is located at the second end of the elongated tube 1, and the displacement hydraulic pressure change amount of the elongated tube 1 is calculated according to the pressure measurement data, including:

[0055] After the elongated tube 1 is connected to the displacement liquid, the displacement hydraulic pressure value of the first end of the elongated tube 1 is detected by the first pressure sensor to obtain a first pressure detection value, and the displacement hydraulic pressure value of the second end of the elongated tube 1 is detected by the second pressure sensor to obtain a second pressure detection value, and the displacement hydraulic pressure change amount of the elongated tube 1 is calculated according to the difference between the first pressure detection value and the second pressure detection value.

[0056] Wherein the first pressure detection value represents the displacement hydraulic pressure of the elongated tube 1 connected from the venous line 5, and the second pressure detection value represents the displacement hydraulic pressure of the elongated tube 1 connected from the power assembly 2, and the displacement hydraulic pressure change amount of the elongated tube 1 can be obtained according to the difference between the first pressure detection value and the second pressure detection value, so as to facilitate subsequent calculation of the viscosity system parameters of the blood purification equipment and the first blood viscosity of the patient's blood.

[0057] The displacement hydraulic pressure change time of the elongated tube 1 and the displacement hydraulic pressure change amount of the elongated tube 1 have a one-to-one correspondence relationship, and the displacement hydraulic pressure change time of the elongated tube 1 represents the time period when the displacement hydraulic pressure of the elongated tube 1 changes, for example: the displacement hydraulic pressure change amount of the elongated tube 1 is 100 mmHg, and the displacement hydraulic pressure change time of the elongated tube 1 refers to the time corresponding to the change of 100 mmHg in the displacement hydraulic pressure of the elongated tube 1.

[0058] Specifically, as an optional implementation, the displacement hydraulic pressure change time of the elongated tube 1 is calculated according to the pressure measurement data, including:

[0059] If the total amount of the replacement fluid connected to the elongated tube 1 is greater than or equal to the preset volume, then the time point at which the elongated tube 1 is not connected to the replacement fluid is taken as a time starting point, the time point at which the total amount of the replacement fluid connected to the elongated tube 1 is greater than or equal to the preset volume is taken as a time ending point, and the replacement fluid pressure change time of the elongated tube 1 = time ending point - time starting point.

[0060] In step S430, the viscosity system parameter is determined according to the preset viscosity of the replacement fluid, the replacement fluid pressure change amount of the elongated tube 1, and the replacement fluid pressure change time of the elongated tube 1.

[0061] Generally, the replacement fluid is water for injection, the viscosity of water is usually a constant value, and water does not have a concentration problem. Those skilled in the art can refer to relevant technical documents to determine the viscosity of water, and approximate fit the viscosity of the preset replacement fluid through the viscosity of water, for example, the viscosity of water is 100 Pa.S, and the viscosity of the preset replacement fluid is 100 Pa.S.

[0062] The viscosity system parameter can be calculated by the following formula by determining the preset viscosity of the replacement fluid, the replacement fluid pressure change amount of the elongated tube 1, and the replacement fluid pressure change time of the elongated tube 1:

[0063] The viscosity system parameter k = replacement fluid pressure change amount / (preset viscosity of the replacement fluid x replacement fluid pressure change time).

[0064] In step S440, the blood is dialyzed through the dialyzer 3 according to the blood treatment instruction output by the user, and the blood after dialysis is output to the elongated tube 1 through the power assembly 2.

[0065] After the blood purification equipment passes through the pre-flushing stage, the processor controls the blood purification equipment to enter the blood treatment stage. When the user outputs the blood treatment instruction, the blood purification equipment enters the blood treatment stage according to the blood treatment instruction. In the blood treatment stage, one end of the arterial pipeline 4 is connected to the blood, the blood flows through the arterial pipeline 4, the dialyzer 3, and the venous pipeline 5 in turn, and the dialyzer 3 performs hemodialysis on the blood. The blood after hemodialysis is returned to the vein of the patient through the venous pipeline 5. When there is flowing blood in the venous pipeline 5, the driving force is provided by the power assembly 2 to make the elongated tube 1 suck the blood from the venous pipeline 5, that is, the elongated tube 1 is connected to the blood through the power assembly 2.

[0066] In step S450, the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1 are calculated according to the pressure measurement data.

[0067] When the elongated tube 1 accesses blood, the blood pressure of the elongated tube 1 gradually increases, for example, the blood pressure variation of the elongated tube 1 is 100mmHg (the positive blood pressure variation value represents that the blood pressure of the elongated tube 1 gradually increases, and the negative blood pressure variation value represents that the blood pressure of the elongated tube 1 gradually decreases), the pressure sensor 6 can measure the blood pressure of the elongated tube 1, obtain pressure measurement data, and calculate the first blood pressure variation of the elongated tube 1 and the first blood pressure variation time of the elongated tube 1 through the pressure measurement data.

[0068] Specifically, as an optional implementation, referring to Figure 1 The pressure sensor 6 can be arranged at the first end of the elongated tube 1, and the first blood pressure variation of the elongated tube 1 is calculated according to the pressure measurement data, including:

[0069] If the total amount of blood accessed by the elongated tube 1 is greater than or equal to the preset volume, the blood pressure value of the elongated tube 1 is measured by the pressure sensor 6, and the first blood pressure variation of the elongated tube 1 is calculated according to the blood pressure value of the elongated tube 1 and the pressure value of the elongated tube 1 without accessing blood.

[0070] The preset volume is a value set in advance, and the preset volume is related to the diameter of the elongated tube 1 and the length of the elongated tube 1. Those skilled in the art can set it according to the actual situation, for example, the diameter of the elongated tube 1 is 1mm, the length of the elongated tube 1 is 200mm, and the preset volume can be 200uL. When it is detected that the total amount of blood accessed by the elongated tube 1 is greater than or equal to 200uL, the blood pressure value of the elongated tube 1 is measured by the pressure sensor 6.

[0071] The first blood pressure variation = the fourth pressure detection value-the third pressure detection value, wherein the third pressure detection value represents the blood pressure value of the elongated tube 1 measured by the pressure sensor 6 when the elongated tube 1 does not access blood, and the fourth pressure detection value represents the blood pressure value of the elongated tube 1 measured by the pressure sensor 6 when the total amount of blood accessed by the elongated tube 1 is greater than or equal to the preset volume.

[0072] As another optional implementation, referring to Figure 2 The pressure sensor 6 can also include a first pressure sensor and a second pressure sensor, the first pressure sensor is located at the first end of the elongated tube 1, and the second pressure sensor is located at the second end of the elongated tube 1. The first blood pressure variation of the elongated tube 1 is calculated according to the pressure measurement data, including:

[0073] After the elongated tube 1 is connected to the blood, the blood pressure value at the first end of the elongated tube 1 is detected by the first pressure sensor to obtain a third pressure detection value, and the blood pressure value at the second end of the elongated tube 1 is detected by the second pressure sensor to obtain a fourth pressure detection value, and the first blood pressure change amount of the elongated tube 1 is calculated according to the difference between the third pressure detection value and the fourth pressure detection value.

[0074] The third pressure detection value represents the blood pressure of the elongated tube 1 connected to the venous line 5, and the fourth pressure detection value represents the pressure of the power assembly 2 inhaling blood from the elongated tube 1, and the first blood pressure change amount of the elongated tube 1 can be obtained according to the difference between the third pressure detection value and the fourth pressure detection value, so that the first blood viscosity of the patient's blood can be calculated subsequently.

[0075] The first blood pressure change time of the elongated tube 1 and the first blood pressure change amount of the elongated tube 1 have a one-to-one correspondence, and the first blood pressure change time of the elongated tube 1 represents the time period when the first blood pressure of the elongated tube 1 changes.

[0076] Specifically, as an optional embodiment, the first blood pressure change time of the elongated tube 1 is calculated according to the pressure measurement data, comprising:

[0077] If the total amount of blood connected to the elongated tube 1 is greater than or equal to the preset volume, then the time starting point is the time point when the elongated tube 1 is not connected to the blood, and the time ending point is the time point when the total amount of blood connected to the elongated tube 1 is greater than or equal to the preset volume, and the blood pressure change time of the elongated tube 1 = time ending point - time starting point.

[0078] Step S460, according to the viscosity system parameter, the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1, the first blood viscosity is determined.

[0079] The viscosity system parameter k, the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1 can be calculated by the following formula to calculate the first blood viscosity:

[0080] The first blood viscosity = the first blood pressure change amount / (the viscosity system parameter k x the first blood pressure change time).

[0081] The first blood viscosity can be calculated according to the above formula, because the first blood pressure change amount, the viscosity system parameter k and the first blood pressure change time are known quantities. In this embodiment, the first blood viscosity can be obtained during the blood treatment stage, and the hemodialysis state of the patient can be monitored according to the first blood viscosity.

[0082] The blood purification device provided in the embodiments of the present application utilizes the operation steps in the hemodialysis process to obtain the viscosity system parameters necessary in the viscosity detection process in the pre-flushing stage, so as to provide a data basis for the calculation process of the blood viscosity in the later stage, facilitate the accurate calculation of the blood viscosity of the patient when the patient is subjected to hemodialysis, and effectively combine the blood viscosity detection and the hemodialysis process, and effectively integrate the viscosity detection into the hemodialysis process. The blood viscosity of the patient can be detected and monitored in real time in the blood treatment stage, and the method has strong practicality and convenience. In addition, in the embodiments of the present application, the method of determining the blood viscosity by skillfully utilizing the change of the pressure of the inhaled fluid medium with time can effectively obtain the blood viscosity value, has low detection cost, high detection feasibility and high detection reliability, and can detect the blood viscosity in real time in the hemodialysis process. Medical staff can refer to the evaluation process of the hemodialysis effect according to the blood viscosity, avoid the occurrence of cardiovascular and other related complications of the patient, and further ensure the safety of the patient in the hemodialysis process, thereby overcoming the problem that the blood viscosity of the patient cannot be detected in the hemodialysis process in the prior art, resulting in low safety of the hemodialysis treatment of the patient.

[0083] On the basis of the above-mentioned embodiments, the blood purification device further comprises a display screen 26, and after the first blood viscosity is determined according to the viscosity system parameters, the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1 in step S460, the blood purification device further comprises:

[0084] The processor is further configured to display the change curve of the first blood viscosity with time through the display screen 26.

[0085] The first blood viscosity is not a fixed value, but a value obtained by real-time detection and calculation in the blood treatment stage. The first blood viscosity obtained at different times in the blood treatment stage also changes, so that the change curve of the first blood viscosity with time can be drawn. The user can judge the hemodialysis treatment effect of the patient according to the change curve of the first blood viscosity with time.

[0086] Figure 5 The change curve of the first blood viscosity with time is combined with Figure 5As shown, generally, the first blood viscosity gradually increases with the increase of time, and the user can obtain the hemodialysis treatment effect of the patient according to the first blood viscosity curve changing with time, and can obtain the fluctuation state of the hemodialysis treatment according to the first blood viscosity curve changing with time, thereby ensuring the safety of the hemodialysis treatment of the patient. For example, when the first blood viscosity curve changing with time becomes a horizontal line, it indicates that the blood treatment stage is in a fault state, and the user can handle the fault state of the dialyzer 3 in time according to the first blood viscosity curve changing with time displayed on the display screen 26, thereby ensuring the safety of the hemodialysis treatment of the patient.

[0087] It should be noted that the hemodialysis treatment effect includes multiple indexes such as the dehydration amount of the dialyzer and the clearance rate of urea in the blood of the dialyzer, and those skilled in the art can determine whether these indexes are normal according to the first blood viscosity curve changing with time.

[0088] On the basis of the above embodiment, before the dialysis of the blood by the dialyzer 3 according to the blood treatment instruction output by the user, the processor is further configured to execute the following steps:

[0089] determining whether the time when the arterial pipeline 4 accesses the replacement fluid is greater than a preset priming time, and if the time when the arterial pipeline 4 accesses the replacement fluid is greater than the preset priming time, issuing a blood drawing start instruction.

[0090] The control process of the blood purification device can be in sequence: a priming stage, a blood drawing stage and a blood treatment stage, when the time when the arterial pipeline 4 accesses the replacement fluid is greater than the preset priming time, it indicates that the blood purification device has completed the priming stage, and the blood purification device can be controlled to enter the blood drawing stage by the blood drawing start instruction. The preset priming time represents the maximum time for the blood purification device to prime, and the preset priming time can be set by those skilled in the art according to clinical experience, for example, in the hemodialysis mode, the preset priming time is usually 5 min to 8 min.

[0091] On the basis of the above embodiment, the blood purification device further comprises a blood detector 7, the blood detector 7 is arranged on the venous pipeline 5, specifically, the first end of the venous pipeline 5 is connected to the blood output end of the dialyzer 3, the second end of the venous pipeline 5 is connected to the vein of the patient, the first end of the elongated tube 1 is connected to the connection point of the venous pipeline 5, and the blood detector 7 is arranged on the pipeline between the connection point of the venous pipeline 5 and the second end of the venous pipeline 5, the blood detector 7 is used to detect whether there is blood in the venous pipeline 5, and the processor is further configured to execute the following steps:

[0092] According to the blood introduction start instruction output by the user, blood is output to the arterial line 4, the dialyzer 3 and the venous line 5, and when the blood detector 7 detects the presence of blood in the venous line 5, the blood is output to the elongated tube 1 by the power assembly 2.

[0093] In the blood introduction stage, blood is accessed through the arterial line 4, and the blood flows through the arterial line 4, the dialyzer 3 and the venous line 5 in turn. The blood detector 7 detects whether there is blood in the venous line 5 by using the principle of light sensing. When the blood detector 7 detects the presence of blood in the venous line 5, the power assembly 2 is controlled to provide driving force, so that the elongated tube 1 sucks blood from the venous line 5, i.e. the blood is output to the elongated tube 1 by the power assembly 2.

[0094] The second blood pressure change amount of the elongated tube 1 and the second blood pressure change time of the elongated tube 1 are calculated according to the pressure measurement data.

[0095] When the elongated tube 1 accesses blood, the blood pressure of the elongated tube 1 gradually increases. The pressure sensor 6 can measure the blood pressure of the elongated tube 1 to obtain pressure measurement data, and calculate the second blood pressure change amount of the elongated tube 1 and the second blood pressure change time of the elongated tube 1 according to the pressure measurement data. The method of calculating the second blood pressure change amount of the elongated tube 1 and the second blood pressure change time of the elongated tube 1 according to the pressure measurement data is the same as the method of calculating the first blood pressure change amount of the elongated tube 1 and the first blood pressure change time of the elongated tube 1 according to the pressure measurement data, which will not be described here.

[0096] The second blood viscosity is determined according to the viscosity system parameter, the second blood pressure change amount of the elongated tube 1 and the second blood pressure change time of the elongated tube 1.

[0097] After the viscosity system parameter k, the second blood pressure change amount of the elongated tube 1 and the second blood pressure change time of the elongated tube 1 are determined, the second blood viscosity can be calculated by the following formula:

[0098] The second blood viscosity = the second blood pressure change amount / (the viscosity system parameter k x the second blood pressure change time).

[0099] It should be noted that the first blood viscosity and the second blood viscosity have completely different physiological reference values. The first blood viscosity is the blood viscosity of the patient detected in the blood treatment stage, representing the blood viscosity in the blood treatment stage. The second blood viscosity is the blood viscosity of the patient detected in the blood drawing stage, representing the blood viscosity of the patient before hemodialysis. When the patient is treated by hemodialysis, the blood viscosity of the patient is usually low in the blood drawing stage (because there is more water in the blood of the patient at this time), and the blood viscosity of the patient is usually high in the blood treatment stage (because the excess water in the blood of the patient is removed after hemodialysis). According to the first blood viscosity and the second blood viscosity, the dehydration effect of the dialyzer can be determined.

[0100] On the basis of the above embodiment, the processor is further configured to perform:

[0101] According to the difference between the first blood viscosity and the second blood viscosity, the dehydration effect of the dialyzer 3 is determined.

[0102] The first blood viscosity represents the blood viscosity in the blood treatment stage, and the second blood viscosity represents the blood viscosity before hemodialysis. The difference between the first blood viscosity and the second blood viscosity represents the change amount of the blood viscosity of the patient after hemodialysis. The greater the difference between the first blood viscosity and the second blood viscosity, the greater the dehydration amount of the patient after hemodialysis. The smaller the difference between the first blood viscosity and the second blood viscosity, the smaller the dehydration amount of the patient after hemodialysis. During hemodialysis, the blood is dehydrated by the dialyzer 3. Under normal circumstances, as the hemodialysis treatment time increases, the blood viscosity of the patient also gradually increases, so the first blood viscosity increases as the hemodialysis treatment time increases. The greater the difference between the first blood viscosity and the second blood viscosity, the better the dehydration effect of the dialyzer 3, and the greater the actual dehydration amount of the blood of the patient. The smaller the difference between the first blood viscosity and the second blood viscosity, the worse the dehydration effect of the dialyzer 3, and the smaller the actual dehydration amount of the blood of the patient. According to the difference between the first blood viscosity and the second blood viscosity, the dehydration effect of the dialyzer 3 is directly determined, without the need to calculate the actual dehydration amount of the blood of the patient and then determine the dehydration effect of the dialyzer 3. This simplifies the steps of determining the dehydration effect of the dialyzer 3, improves the accuracy of the determination, and the method of determining the dehydration effect of the dialyzer 3 in this embodiment is scientific and reasonable.

[0103] On the basis of the above embodiment, according to the difference between the first blood viscosity and the second blood viscosity, the dehydration effect of the dialyzer 3 is determined. Specifically, the following method can be used:

[0104] If it is judged that the difference between the first blood viscosity and the second blood viscosity meets the first preset condition, the dehydration effect of the dialyzer 3 is poor, and a first prompt is issued;

[0105] If it is judged that the difference between the first blood viscosity and the second blood viscosity meets the second preset condition, the dehydration effect of the dialyzer 3 is good, and a second prompt is issued;

[0106] If it is judged that the difference between the first blood viscosity and the second blood viscosity meets the third preset condition, the dehydration effect of the dialyzer 3 is good, and a third prompt is issued;

[0107] The first preset condition is that |first blood viscosity-second blood viscosity|≤first preset difference value;

[0108] The second preset condition is that first preset difference value<|first blood viscosity-second blood viscosity|≤second preset difference value;

[0109] The third preset condition is that second preset difference value<|first blood viscosity-second blood viscosity|.

[0110] The first preset difference value and the second preset difference value are values set in advance, which can be set according to clinical experience by those skilled in the art, and the embodiments of the present application do not make further limitations thereon, for example, the first preset difference value is 10 Pa.S, and the second preset difference value is 30 Pa.S.

[0111] In the embodiment, the dehydration effect of the dialyzer 3 is divided into three grades, poor, general, and good, according to the relationship between the first blood viscosity and the second blood viscosity and the first preset difference value and the second preset difference value, and different prompts are issued for different dehydration effects, so that the actual dehydration effect of the dialyzer 3 can be clearly understood. The first prompt, the second prompt, and the third prompt can be different light prompts or different sound prompts, for example, the first prompt can be red light, the second prompt can be blue light, and the third prompt can be green light. When the user sees different colored light sources, the actual dehydration effect of the dialyzer 3 can be known according to different light sources, so that the actual hemodialysis state of the patient can be directly understood.

[0112] On the basis of the above-mentioned embodiments, after the second blood viscosity is determined according to the viscosity system parameter, the second blood pressure change amount of the elongated tube 1, and the second blood pressure change time of the elongated tube 1, the method further comprises:

[0113] The target dehydration amount of the dialyzer 3 is determined according to the second blood viscosity, and the processor is further configured to display the target dehydration amount of the dialyzer 3 on the display screen 26.

[0114] The second blood viscosity represents the water content in the blood of the patient before hemodialysis, for example, the second blood viscosity is 50 Pa.S, and the target dehydration amount of the dialyzer 3 represents a specific total amount of water removed from the blood of the patient during the blood treatment phase. There is a negative correlation between the second blood viscosity and the target dehydration amount, that is, when the second blood viscosity is large, it means that the water content in the blood of the patient is not high, and the blood of the patient is dehydrated, and the target dehydration amount is low at this time; when the second blood viscosity is small, it means that the water content in the blood of the patient is high, and the blood of the patient is dehydrated, and the target water content is high at this time. There is also a one-to-one correspondence between the second blood viscosity and the target dehydration amount, and a relationship diagram between the second blood viscosity and the target dehydration amount is shown in FIG. 8. Figure 6 Figure 6 The corresponding curve between the second blood viscosity and the target dehydration amount is obtained by technicians in the art according to clinical experience. When the second blood viscosity is determined, the corresponding target dehydration amount can be determined according to the corresponding curve. Figure 6 Therefore, during the blood treatment phase, when the dialyzer 3 performs dialysis on the blood, the actual dehydration amount of the dialyzer 3 can be detected, and when the actual dehydration amount of the dialyzer 3 is equal to the target dehydration amount, the dialyzer 3 can be controlled to stop the hemodialysis, so that the patient achieves the best hemodialysis treatment effect. In the embodiment, the target dehydration amount of the dialyzer 3 is scientifically and reasonably determined according to the second blood viscosity, which facilitates the dialyzer 3 to stop the hemodialysis process at an appropriate time in the later stage, thereby ensuring a better hemodialysis treatment effect.

[0115] In the embodiment, the dehydration effect of the dialyzer can be judged according to the difference between the blood viscosity in the blood withdrawal phase and the blood viscosity in the blood treatment phase, and an effective and scientific reference index is provided for medical staff, so that the medical staff can directly judge whether the patient is in a normal dehydration state during hemodialysis according to the difference between the first blood viscosity and the second blood viscosity, which is beneficial to improve the judgment accuracy, thereby preventing excessive water loss or excessive fluid replacement during the hemodialysis process of the dialyzer, causing problems such as too low blood concentration and blood cell deformation, effectively preventing cardiovascular-related complications caused during the hemodialysis process, and improving the safety of the patient during the blood treatment process.

[0116] On the basis of the above-mentioned embodiments, the blood purification apparatus further comprises a first temperature sensor and a second temperature sensor (not shown in the figure), the first temperature sensor is used to detect the blood temperature in the arterial pipeline 4 to obtain a first detection temperature, and the second temperature sensor is used to detect the blood temperature in the venous pipeline 5 to obtain a second detection temperature, and the processor is further used to execute:

[0117] ​determining whether the absolute value of the difference between the first detection temperature and the second detection temperature is less than a preset temperature difference value, and if the absolute value of the difference between the first detection temperature and the second detection temperature is less than the preset temperature difference value, determining the first blood viscosity according to the viscosity system parameter, the first blood pressure change amount of the elongated tube 1, and the first blood pressure change time of the elongated tube 1.

[0118] The first detection temperature represents the temperature of the blood directly extracted from the patient, the second detection temperature represents the temperature of the blood after hemodialysis, and the difference between the first detection temperature and the second detection temperature represents the temperature change amount of the blood of the patient caused by hemodialysis. The preset temperature difference value represents the allowable temperature change error of the blood of the patient during hemodialysis. In the embodiments of the present application, the specific value of the preset temperature difference value is not further limited, and a person skilled in the art can set it according to clinical treatment experience. For example, the preset temperature difference value is 2°C.

[0119] When the hemodialysis process of the patient is in a normal state, the difference between the first detection temperature and the second detection temperature will not be too large, that is, the absolute value of the difference between the first detection temperature and the second detection temperature is less than the preset temperature difference value. In the normal hemodialysis state, the first blood viscosity can be calculated according to the viscosity system parameter, the first blood pressure change amount of the elongated tube, and the first blood pressure change time of the elongated tube, so that the hemodialysis state of the patient can be monitored according to the first blood viscosity. However, when the hemodialysis process of the patient is in an abnormal state, the difference between the first detection temperature and the second detection temperature is large, that is, the absolute value of the difference between the first detection temperature and the second detection temperature is greater than or equal to the preset temperature difference value, which indicates that the temperature of the blood of the patient during the dialysis process has failed. These failures may be membrane rupture failure of the dialyzer, blockage of the blood flowing in the dialyzer, etc. to cause temperature abnormalities. When the temperature of the blood of the patient during the dialysis process fails, it is meaningless to calculate the first blood viscosity. Therefore, in the blood treatment stage, the first detection temperature and the second detection temperature can be detected in real time, and it is determined whether the temperature during the hemodialysis process has failed, and when the absolute value of the difference between the first detection temperature and the second detection temperature is less than the preset temperature difference value, the first blood viscosity is calculated, and the hemodialysis state of the patient is monitored according to the first blood viscosity.

[0120] For example, if the first detection temperature is 36°C, the second detection temperature is 35°C, the preset temperature difference is 2°C, and the absolute value of the difference between the first detection temperature and the second detection temperature is 1°C, which is less than the preset temperature difference, the hemodialysis process of the patient is in a normal state. The first blood viscosity can be calculated according to the viscosity system parameter, the first blood pressure change amount of the elongated tube 1, and the first blood pressure change time of the elongated tube 1, so that the hemodialysis state of the patient can be monitored according to the first blood viscosity. If the first detection temperature is 38°C, the second detection temperature is 34°C, the preset temperature difference is 2°C, and the absolute value of the difference between the first detection temperature and the second detection temperature is 4°C, which is greater than the preset temperature difference, the hemodialysis process of the patient is in an abnormal state, and the first blood viscosity does not need to be calculated at this time.

[0121] On the basis of the above embodiment, after the first blood viscosity is determined according to the viscosity system parameter, the first blood pressure change amount of the elongated tube 1, and the first blood pressure change time of the elongated tube 1 in step S460, the processor is further configured to perform:

[0122] The power assembly 2 controls the power assembly 2 to return all the blood remaining in the power assembly 2 and the blood remaining in the elongated tube 1 to the venous line 5 through the elongated tube 1.

[0123] In order to ensure that the hemodialysis state of the patient can be monitored in real time, the first blood viscosity of the patient is periodically detected and calculated during the blood treatment stage. When the first blood viscosity is determined each time, the driving force is provided by the power assembly 2 to make the elongated tube 1 suck blood from the venous line 5. The blood is stored in the power assembly 2 and the elongated tube 1. This part of blood not only causes the waste of blood, but also affects the accuracy of the subsequent first blood viscosity. Therefore, after the first blood viscosity is determined each time, the remaining blood needs to be returned to the venous line 5, so that when the blood viscosity of the patient is detected in real time during the blood treatment stage, the waste of blood in the venous line 5 can be avoided, the blood viscosity detection cost of the patient is reduced, and the accuracy and reliability of the blood viscosity detection are improved.

[0124] The power assembly 2 of the embodiment can include a syringe and a driving assembly for providing driving force to the syringe for accessing and storing liquid. During the blood treatment stage, the syringe is controlled to move by the driving assembly to access blood in the venous line 5 through the elongated tube 1 for storing the blood in the syringe, and the first blood viscosity is calculated according to the pressure measurement data, the first blood pressure change amount of the elongated tube 1, and the first blood pressure change time of the elongated tube 1 when the blood is transmitted by the elongated tube 1. After each detection and calculation of the first blood viscosity of the patient, there is residual blood in the syringe and the elongated tube 1. In order to avoid blood waste and affect the accuracy of subsequent first blood viscosity detection, the residual blood in the syringe and the elongated tube 1 is completely returned to the venous line 5 after each detection of the first blood viscosity, and the residual blood is returned to the patient's vein through the venous line 5, thereby solving the problems of blood waste and affecting the accuracy of subsequent first blood viscosity detection in the calculation process of the first blood viscosity. Of course, the power assembly 2 in the embodiment of the application can also be other devices as long as the above functions are realized. The specific composition of the driving assembly in the embodiment of the application is not limited further, and a person skilled in the art can set it according to the actual situation.

[0125] On the basis of the above embodiment, after determining the first blood viscosity according to the viscosity system parameter, the first blood pressure change amount of the elongated tube 1, and the first blood pressure change time of the elongated tube 1 in step S460, the processor is further configured to execute:

[0126] Detecting whether the blood in the venous line 5 appears coagulation phenomenon, and if the blood in the venous line 5 appears coagulation phenomenon, issuing a fault prompt operation.

[0127] The coagulation phenomenon refers to that the blood contacts the wall of the venous line 5, triggers the coagulation mechanism of the blood, and causes the blood in the venous line 5 to appear coagulation phenomenon. Since the blood in the venous line 5 needs to be guided out through the elongated tube 1 when the first blood viscosity of the patient is detected during the blood treatment stage, the blood flow in the venous line 5 will be reduced, and thus the blood in the venous line 5 is more likely to appear coagulation phenomenon. In order to ensure the safety of the hemodialysis treatment of the patient, it is necessary to detect whether the blood in the venous line appears coagulation phenomenon.

[0128] In the embodiment, when the first blood viscosity is determined, it is detected whether the blood in the venous pipeline 5 appears coagulation phenomenon, if the blood in the venous pipeline 5 appears coagulation phenomenon, a fault prompt operation is sent, so that the user can timely deal with the coagulation phenomenon of the venous pipeline 5, thereby preventing the coagulation phenomenon of the venous pipeline 5 from endangering the safety of the hemodialysis treatment of the patient.

[0129] It should be noted that the fault prompt operation in the embodiment belongs to an audible and visual signal, if the blood in the venous pipeline appears coagulation phenomenon, a sound prompt operation can be sent, or a text prompt operation is displayed on the display screen 26, so as to achieve the effect of fault alarm.

[0130] On the basis of the above embodiment, before the displacement fluid is output to the arterial pipeline 4, the dialyzer 3 and the venous pipeline 5 according to the pre-flush start instruction output by the user and is output to the elongated tube 1 through the power assembly 2 in step S410, the processor is further configured to execute:

[0131] detect the displacement fluid flow in the venous pipeline 5, and determine whether the displacement fluid flow in the venous pipeline 5 is greater than or equal to the pre-set displacement fluid flow, if the displacement fluid flow in the venous pipeline 5 is greater than or equal to the pre-set displacement fluid flow, the displacement fluid is output to the elongated tube 1 through the power assembly 2.

[0132] In the pre-flush stage, the displacement fluid flows through the arterial pipeline 4, the dialyzer 3 and the venous pipeline 5 in sequence, and the pre-flush stage is mainly used to detect the viscosity system parameter of the blood purification device, in order to improve the detection accuracy of the viscosity system parameter, by increasing the displacement fluid flow in the venous pipeline 5, the viscosity system parameter detected by the displacement fluid flow in the venous pipeline 5 has higher accuracy. When the displacement fluid flow in the venous pipeline 5 is greater than or equal to the pre-set displacement fluid flow, the change amount of the displacement fluid pressure of the elongated tube 1 detected can truly reflect the viscosity of the displacement fluid, and thus more accurate viscosity system parameter is obtained, but when the displacement fluid flow in the venous pipeline 5 is less than the pre-set displacement fluid flow, it indicates that the displacement fluid flow in the venous pipeline 5 is insufficient, in this case, the viscosity system parameter detected will be disturbed by the displacement fluid flow, thereby causing a large detection error of the first blood viscosity of the patient in the blood treatment stage. By limiting the relationship between the displacement fluid flow in the venous pipeline 5 in the pre-flush stage and the pre-set displacement fluid flow, the error of the viscosity system parameter caused by the change of the displacement fluid flow can be excluded, thereby the accuracy of the first blood viscosity detection in the embodiment can be improved.

[0133] On the basis of the above embodiments, after calculating the displacement fluid pressure change amount of the elongated tube 1 and the displacement fluid pressure change time of the elongated tube 1 according to the pressure measurement data in step S420, and before determining the viscosity system parameter according to the preset viscosity of the displacement fluid, the displacement fluid pressure change amount of the elongated tube 1, and the displacement fluid pressure change time of the elongated tube 1 in step S430, the processor is further configured to perform:

[0134] detecting whether the displacement fluid in the venous line 5 has air bubbles, and if the displacement fluid in the venous line 5 has air bubbles, calibrating the displacement fluid pressure change amount of the elongated tube 1, and determining the viscosity system parameter according to the preset viscosity of the displacement fluid, the calibrated displacement fluid pressure change amount of the elongated tube 1, and the displacement fluid pressure change time of the elongated tube 1.

[0135] If the displacement fluid in the venous line 5 has no air bubbles, the displacement fluid pressure change amount of the elongated tube 1 does not need to be calibrated, and the viscosity system parameter can be directly determined according to the preset viscosity of the displacement fluid, the displacement fluid pressure change amount of the elongated tube 1, and the displacement fluid pressure change time of the elongated tube 1.

[0136] In the pre-flushing stage, some air bubbles may be mixed in the displacement fluid in the venous line 5 during the process of sequentially flushing the arterial line 4, the dialyzer 3, and the venous line 5 by the displacement fluid. When the pressure sensor 6 detects the displacement fluid pressure change amount of the elongated tube 1, the air bubbles in the displacement fluid will affect the pressure detection accuracy of the pressure sensor 6. In order to exclude the interference of the air bubbles on the displacement fluid pressure change amount of the elongated tube 1, the embodiment first detects whether the displacement fluid in the venous line 5 has air bubbles. If it is detected that the displacement fluid in the venous line 5 has air bubbles, the displacement fluid pressure change amount of the elongated tube 1 is calibrated. The displacement fluid pressure change amount of the elongated tube 1 after calibration may increase or decrease, but the viscosity system parameter can be more accurately calculated according to the calibrated displacement fluid pressure change amount of the elongated tube 1, so that the first blood viscosity of the patient can be accurately calculated in the later stage, thereby improving the detection accuracy of the first blood viscosity in the embodiment.

[0137] In the embodiment, a bubble detector 25 can be arranged on the venous line 5 to detect whether the displacement fluid in the venous line 5 has air bubbles. The method for detecting whether the displacement fluid in the venous line 5 has air bubbles is not limited in the embodiment, and a person skilled in the art can select according to the actual situation. For example, an ultrasonic detection method can be used to detect the displacement fluid in the venous line 5, convert the amount of air bubbles in the displacement fluid from a non-electric quantity into an electric signal, for example, convert the amount of air bubbles in the displacement fluid from a non-electric quantity into a voltage signal, and by comparing the difference between the voltage signal and the preset voltage signal, whether the displacement fluid in the venous line 5 has air bubbles can be identified.

[0138] The skilled in the art can set a fixed pressure calibration value according to clinical experience, and calibrate the replacement fluid pressure change amount of the elongated tube 1 according to the pressure calibration value. For example, if the pressure calibration value is -10 mmHg, the calibrated replacement fluid pressure change amount of the elongated tube 1 = the replacement fluid pressure change amount of the elongated tube 1 - 10 mmHg. The skilled in the art can also set a corresponding curve between the air bubble amount of the replacement fluid in the venous line 5 and the pressure calibration value according to clinical experience. The corresponding pressure calibration value is found through the corresponding curve by detecting the air bubble amount of the replacement fluid in the venous line 5. The calibrated replacement fluid pressure change amount of the elongated tube 1 is obtained according to the replacement fluid pressure change amount of the elongated tube 1 and the pressure calibration value. Of course, the skilled in the art can also calibrate the replacement fluid pressure change amount of the elongated tube 1 according to the traditional intelligent algorithm (for example, genetic algorithm). The method for calibrating the replacement fluid pressure change amount of the elongated tube 1 in the embodiment is not limited further, and the skilled in the art can select according to the actual situation.

[0139] In an alternative embodiment, a blood purification apparatus is provided, as shown in Figure 3 Figure 3 The blood purification apparatus 300 shown in the embodiment includes a processor 301 and a memory 303. The processor 301 and the memory 303 are connected, for example, through a bus 302. Optionally, the blood purification apparatus 300 can also include a transceiver 304. It should be noted that the actual application of the transceiver 304 is not limited to one, and the structure of the electronic device 300 does not constitute a limitation on the embodiments of the present application.

[0140] The processor 301 can be a CPU (Central Processing Unit, central processor), a general-purpose processor, a DSP (Digital Signal Processor, data signal processor), an ASIC (Application Specific Integrated Circuit, application specific integrated circuit), an FPGA (Field Programmable Gate Array, field programmable gate array) or other programmable logic devices, transistor logic devices, hardware components or any combination thereof. It can realize or execute various exemplary logical blocks, modules and circuits described in combination with the disclosure content of the present application. The processor 301 can also be a combination of computing functions, such as one or more microprocessor combinations, combinations of DSP and microprocessor, etc.

[0141] ​The bus 302 can include a path that transmits information between the above-mentioned components. The bus 302 can be a PCI (Peripheral Component Interconnect) bus or an EISA (Extended Industry Standard Architecture) bus, etc. The bus 302 can be divided into an address bus, a data bus, a control bus, etc. For convenience of representation, Figure 3 only one bus or one type of bus is represented by a thick line, but this does not mean that there is only one bus or one type of bus.

[0142] The memory 303 can be a ROM (Read Only Memory) or other type of static storage device that can store static information and instructions, a RAM (Random Access Memory) or other type of dynamic storage device that can store information and instructions, an EEPROM (Electrically Erasable Programmable Read Only Memory), a CD-ROM (Compact Disc Read Only Memory) or other optical disk storage, a magnetic disk storage medium or other magnetic storage device, or any other medium that can be used to carry or store desired program code in the form of instructions or data structures and that can be accessed by a computer, but is not limited to this.

[0143] The memory 303 is used to store application program codes for implementing the scheme of the present application, and is controlled by the processor 301 to execute. The processor 301 is used to execute the application program codes stored in the memory 303 to realize the content shown in the foregoing method embodiments.

[0144] The second aspect of the embodiments of the present application provides a computer readable storage medium, which stores a computer program, and the computer program is executed by a processor to implement the method shown in Figure 4 , and the specific process can refer to the description of the method embodiments of Figure 4 , which will not be repeated here.

[0145] Compared with the prior art, the computer readable storage medium uses the operation steps in the hemodialysis process to obtain the viscosity system parameters necessary in the viscosity detection process in the pre-flushing stage, so as to provide a data basis for the calculation process of the blood viscosity in the later stage, facilitate the accurate calculation of the blood viscosity of the patient when the patient is hemodialysis, and effectively combine the blood viscosity detection and the hemodialysis process. The blood viscosity detection is effectively integrated into the hemodialysis process, the blood viscosity of the patient can be detected and monitored in real time in the blood treatment stage, and the method has strong practicality and convenience. In addition, in the embodiment of the application, the method for determining the blood viscosity by skillfully using the change of the pressure of the inhaled fluid medium with time can effectively obtain the blood viscosity value, has low detection cost, high detection feasibility and high detection reliability, and can detect the blood viscosity in real time during the hemodialysis process. Medical staff can refer to the evaluation process of the hemodialysis effect according to the blood viscosity, avoid the occurrence of cardiovascular complications and the like of the patient, and further ensure the safety of the patient during hemodialysis, thereby overcoming the problem that the blood viscosity of the patient cannot be detected during hemodialysis in the prior art, resulting in low safety of the hemodialysis treatment of the patient.

[0146] It should be understood that, although each step in the flowchart of the accompanying drawings is displayed in sequence according to the indication of the arrow, these steps are not necessarily executed in sequence according to the indication of the arrow. Unless otherwise specified herein, the execution of these steps is not strictly limited in sequence, and they can be executed in other sequences. Moreover, at least part of the steps in the flowchart of the accompanying drawings can include multiple sub-steps or multiple stages, which are not necessarily executed at the same time, but can be executed at different times, and the execution sequence is not necessarily sequential, but can be executed in rotation or alternation with at least part of other steps or sub-steps or stages of other steps.

[0147] Although the present disclosure is disclosed as above, the protection scope of the present disclosure is not limited to this. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of the present disclosure, and these changes and modifications will fall within the protection scope of the present disclosure.

Claims

1. A blood purification device, characterized in that, The blood purification device includes: a slender tube, a power unit, a dialyzer, an arterial line, a venous line, a pressure sensor, a processor, and a memory. The arterial line is connected to the blood input end of the dialyzer, the venous line is connected to the blood output end of the dialyzer, the first end of the slender tube is connected to the venous line, the second end of the slender tube is connected to the power unit, and the processor is electrically connected to the memory and the pressure sensor via a bus. The pressure sensor is used to measure the liquid pressure in the slender tube to obtain pressure measurement data; The memory stores program instructions that can be executed by the processor, and the processor can execute the following methods by calling the program instructions: According to the pre-flush start command output by the user, the replacement fluid is output to the arterial line, the dialyzer and the venous line, and output to the slender tube through the power unit; The pressure change of the displacement fluid in the slender tube and the pressure change time of the displacement fluid in the slender tube are calculated based on the pressure measurement data. Based on the preset viscosity of the displacement fluid, the pressure change of the displacement fluid in the slender tube, and the pressure change time of the displacement fluid in the slender tube, the viscosity system parameter k is determined, where the viscosity system parameter k = pressure change of the displacement fluid / (preset viscosity of the displacement fluid × pressure change time of the displacement fluid). According to the blood treatment instructions output by the user, the blood is dialyzed through the dialyzer, and the dialyzed blood is output to the slender tube through the power component; The first blood pressure change in the slender tube and the first blood pressure change time in the slender tube are calculated based on the pressure measurement data. The first blood viscosity is determined based on the viscosity system parameters, the first blood pressure change in the slender tube, and the first blood pressure change time in the slender tube. The first blood viscosity = first blood pressure change / (viscosity system parameter k × first blood pressure change time).

2. The blood purification device according to claim 1, characterized in that, The pressure sensor is located at the first end of the slender tube; The calculation of the displacement fluid pressure change in the slender tube based on the pressure measurement data includes: If the total amount of replacement fluid connected to the slender tube is greater than or equal to a preset volume, the pressure value of the replacement fluid in the slender tube is measured by the pressure sensor, and the change in the replacement fluid pressure in the slender tube is calculated based on the pressure value of the replacement fluid in the slender tube and the pressure value of the slender tube without replacement fluid. The calculation of the first blood pressure change in the slender tube based on the pressure measurement data includes: If the total amount of blood connected to the slender tube is greater than or equal to a preset volume, the blood pressure value of the slender tube is measured by the pressure sensor, and the first blood pressure change of the slender tube is calculated based on the blood pressure value of the slender tube and the pressure value of the slender tube without blood connected to it. Alternatively, the pressure sensor may include a first pressure sensor and a second pressure sensor, wherein the first pressure sensor is located at a first end of the slender tube and the second pressure sensor is located at a second end of the slender tube. The calculation of the displacement fluid pressure change in the slender tube based on the pressure measurement data includes: After the slender tube is connected to the replacement fluid, the pressure value of the replacement fluid at the first end of the slender tube is detected by the first pressure sensor to obtain a first pressure detection value. The pressure value of the replacement fluid at the second end of the slender tube is detected by the second pressure sensor to obtain a second pressure detection value. The change in the replacement fluid pressure of the slender tube is calculated based on the difference between the first pressure detection value and the second pressure detection value. The calculation of the first blood pressure change in the slender tube based on the pressure measurement data includes: After the blood is introduced into the slender tube, the blood pressure value at the first end of the slender tube is detected by the first pressure sensor to obtain a third pressure detection value. The blood pressure value at the second end of the slender tube is detected by the second pressure sensor to obtain a fourth pressure detection value. The first blood pressure change in the slender tube is calculated based on the difference between the third pressure detection value and the fourth pressure detection value.

3. The blood purification device according to claim 1, characterized in that, The processor is further configured to perform the following actions: Dialyzing blood via the dialyzer according to the user's blood treatment instructions; outputting the dialyzed blood through the power assembly to the slender tube; and executing the following functions. Determine whether the time for connecting the arterial tubing to the replacement fluid is greater than the preset pre-flush time. If the time for connecting the arterial tubing to the replacement fluid is greater than the preset pre-flush time, then issue a blood evacuation start command.

4. The blood purification device according to claim 3, characterized in that, Also includes: A blood detector, which is installed on the vein, is used to detect the presence of blood in the vein. The processor is also used to perform: According to the blood draw start command output by the user, blood is output to the arterial line, the dialyzer and the venous line. When the blood detector detects blood in the venous line, the blood is output to the slender tube through the power component. The second blood pressure change in the slender tube and the second blood pressure change time in the slender tube are calculated based on the pressure measurement data. The second blood viscosity is determined based on the viscosity system parameters, the second blood pressure change in the slender tube, and the second blood pressure change time in the slender tube.

5. The blood purification device according to claim 4, characterized in that, The processor is also configured to: determine the dehydration effect of the dialyzer based on the difference between the first blood viscosity and the second blood viscosity.

6. The blood purification device according to claim 5, characterized in that, If it is determined that the difference between the first blood viscosity and the second blood viscosity meets the first preset condition, then the dehydration effect of the dialyzer is poor, and a first prompt is issued; If it is determined that the difference between the first blood viscosity and the second blood viscosity meets the second preset condition, then the dehydration effect of the dialyzer is good, and a second prompt is issued; If it is determined that the difference between the first blood viscosity and the second blood viscosity meets the third preset condition, then the dehydration effect of the dialyzer is good, and a third prompt is issued; The first preset condition is: |first blood viscosity - second blood viscosity| ≤ first preset difference; The second preset condition is: the first preset difference < |first blood viscosity - second blood viscosity| ≤ the second preset difference; The third preset condition is: the second preset difference < |first blood viscosity - second blood viscosity|.

7. The blood purification device according to claim 1, characterized in that, Also includes: First temperature The system includes a temperature sensor and a second temperature sensor. The first temperature sensor is used to detect the blood temperature in the arterial tubing to obtain a first detected temperature, and the second temperature sensor is used to detect the blood temperature in the venous tubing to obtain a second detected temperature. The processor is also used to perform: Determine whether the absolute value of the difference between the first detection temperature and the second detection temperature is less than a preset temperature difference. If the absolute value of the difference between the first detection temperature and the second detection temperature is less than the preset temperature difference, then determine the first blood viscosity based on the viscosity system parameters, the first blood pressure change in the slender tube, and the first blood pressure change time in the slender tube.

8. The blood purification device according to claim 1, characterized in that, Also includes: The processor, after determining the first blood viscosity based on viscosity system parameters, the first blood pressure change in the slender tube, and the first blood pressure change time in the slender tube, is further configured to display the curve of the first blood viscosity changing over time on the display screen.

9. The blood purification device according to claim 1, characterized in that, After determining the first blood viscosity based on viscosity system parameters, the first blood pressure change in the slender tube, and the first blood pressure change time in the slender tube, the processor is further configured to execute: The system detects whether there is blood clotting in the vein. If blood clotting is detected, a fault prompt is issued. And / or, After calculating the displacement fluid pressure change and displacement fluid pressure change time of the slender tube based on the pressure measurement data, and before determining the viscosity system parameters based on the preset viscosity of the displacement fluid, the displacement fluid pressure change of the slender tube, and the displacement fluid pressure change time of the slender tube, the processor is further configured to execute: The presence of air bubbles in the replacement fluid within the venous tubing is detected. If air bubbles are present, the pressure change of the replacement fluid in the slender tube is calibrated. Based on the preset viscosity of the replacement fluid, the calibrated pressure change of the replacement fluid in the slender tube, and the pressure change time of the replacement fluid in the slender tube, the viscosity system parameters are determined.

10. A computer-readable storage medium having a computer program stored thereon, characterized in that, When this computer program is executed by the processor, it implements the following method: Based on the user's pre-flush start command, the replacement fluid is output to the arterial line, dialyzer and venous line, as well as to the slender tube via the power unit; The pressure change of the displacement fluid in the slender tube and the pressure change time of the displacement fluid in the slender tube are calculated based on the pressure measurement data. Based on the preset viscosity of the displacement fluid, the pressure change of the displacement fluid in the slender tube, and the pressure change time of the displacement fluid in the slender tube, the viscosity system parameter k is determined, where the viscosity system parameter k = pressure change of the displacement fluid / (preset viscosity of the displacement fluid × pressure change time of the displacement fluid). According to the blood treatment instructions output by the user, the blood is dialyzed through the dialyzer, and the dialyzed blood is output to the slender tube through the power component; The first blood pressure change in the slender tube and the first blood pressure change time in the slender tube are calculated based on the pressure measurement data. The first blood viscosity is determined based on the viscosity system parameters, the first blood pressure change in the slender tube, and the first blood pressure change time in the slender tube. The first blood viscosity = first blood pressure change / (viscosity system parameter k × first blood pressure change time).

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