A microfluidic device implementing a switch valve

Abstract

The application discloses a micro-fluidic device for realizing a switch valve, and relates to the technical field of micro-fluidics.The micro-fluidic device comprises a fixed outer box, a micro-fluidic chip is fixedly installed on the lower surface of the fixed outer box, a door plate is rotatably installed on one side of the fixed outer box, a handle is fixedly installed on one side of the door plate, a visual window is also fixedly installed on one side of the door plate, and a through groove is formed in the other side of the fixed outer box; the rotating rod is rotated, the rotating rod rotates the cam, the cam vertically lowers the containing bottle through the fixed seat and the rack plate when the protruding position of the cam is in contact with the inner wall of the arc surface groove, the upper end of the inserted needle is inserted into the sealing plug and enters the cavity of the containing bottle along with the vertical lowering of the containing bottle, the fluid in the containing bottle enters the inside of the flow pipe through the inserted needle and flows out through the flow pipe, the micro-fluidic chip reads the flow rate and flow of the fluid at this time, and therefore, the micro-fluid control of the fluid is conveniently realized, and the convenience of the micro-fluid control of the fluid is effectively improved.

Description

Technical Field

[0001] This invention relates to the field of microfluidics, specifically to a microfluidic device for switching valves on and off. Background Technology

[0002] Microfluidics refers to the science and technology involved in systems that use microchannels (tens to hundreds of micrometers in size) to process or manipulate tiny fluids (volumes from nanoliters to attoliters). It is an emerging interdisciplinary field involving chemistry, fluid physics, microelectronics, new materials, biology, and biomedical engineering. Due to their miniaturization and integration characteristics, microfluidic devices are often called microfluidic chips, also known as lab-on-a-chip systems and micro total analysis systems. Early concepts of microfluidics can be traced back to the gas chromatographs fabricated on silicon wafers using photolithography in the 1870s, later evolving into microfluidic capillary electrophoresis apparatus and microreactors. One of the key characteristics of microfluidics is the unique fluid properties at the microscale, such as laminar flow and droplets. Utilizing these unique fluid phenomena, microfluidics can achieve a series of microfabrications and micromanipulations that are difficult to accomplish using conventional methods. Currently, microfluidics is considered to have enormous development potential and broad application prospects in biomedical research. Existing microfluidic devices suffer from the following problems:

[0003] 1. Currently, most existing microfluidic devices cannot easily achieve automatic insertion and separation of the container bottle and needle when controlling the flow of fluid, resulting in a low degree of automation and making microfluidic control of fluids inconvenient.

[0004] 2. At the same time, existing technologies do not allow for convenient disassembly and assembly of the container bottle. When the fluid in the container bottle has drained, it is inconvenient for staff to replace the container bottle, making the replacement of the container bottle rather inconvenient. In order to address the above problems, the inventors have proposed a microfluidic device for realizing the switching of valves to solve the above problems. Summary of the Invention

[0005] To address the inconvenience of microfluidics and the difficulty in changing the container, the present invention aims to provide a microfluidic device for switching valves.

[0006] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: a microfluidic device for realizing the switching of valves, comprising a fixed outer casing, a microfluidic chip fixedly installed on the lower surface of the fixed outer casing, a door panel rotatably installed on one side of the fixed outer casing, a handle fixedly installed on one side of the door panel, a viewing window fixedly installed on one side of the door panel, a through groove opened on the other side of the fixed outer casing, a frame plate provided inside the fixed outer casing, a container bottle detachably installed on the lower surface of the frame plate, a sealing plug movably inserted into the end of the container bottle away from the frame plate, a flow component provided on the surface of the microfluidic chip, a disassembly and assembly mechanism for disassembling and assembling the container bottle provided on the surface of the frame plate, and a pressing mechanism for pressing the container bottle provided inside the fixed outer casing.

[0007] Preferably, the flow assembly includes a connector pin, one end of which is fixedly connected to the upper surface of the microfluidic chip, and a flow tube is fixedly installed inside the microfluidic chip, with the end of the connector pin near the microfluidic chip being fixedly connected to the flow tube.

[0008] Preferably, a plug is movably inserted into one end of the flow tube.

[0009] Preferably, the disassembly and assembly mechanism includes two arc-shaped clamping plates, and arc-shaped anti-slip pads are fixedly installed on the inner walls of the two arc-shaped clamping plates. The inner walls of the two arc-shaped anti-slip pads are in movable contact with the outer wall of the container bottle. A sliding groove is provided on the lower surface of the frame plate, and two sliders are slidably connected to the inner wall of the sliding groove. The lower surface of one slider is fixedly connected to the upper surface of an arc-shaped clamping plate.

[0010] Preferably, a double-ended screw is rotatably mounted on one side of the frame plate. The double-ended screw passes through a sliding groove and is rotatably connected to two sliders by threads. One end of the double-ended screw passes through a through groove, and a handle is fixedly mounted on one end of the double-ended screw.

[0011] Preferably, the pressing mechanism includes a rotating rod, which is rotatably connected to one side of the fixed outer box. A cam is fixedly installed at one end of the rotating rod, and a fixed seat is fixedly installed on the upper surface of the frame plate. An arc groove is formed on the side of the fixed seat away from the frame plate, and the cam and the arc groove are vertically corresponding.

[0012] Preferably, a servo motor is fixedly mounted on one side of the fixed outer casing, and the end of the rotating rod away from the cam is fixedly connected to the drive output end of the servo motor.

[0013] Preferably, a fixing block is fixedly installed on the outer wall of the servo motor, and one side of the fixing block is fixedly connected to one side of the fixed outer casing.

[0014] Preferably, the inner wall of the fixed outer casing is provided with evenly distributed guide grooves, and a guide block is slidably connected to the inner wall of the guide groove. A fixed rod is fixedly installed on one side of the guide block, and the end of the fixed rod away from the guide block is fixedly connected to the lower surface of the frame plate. A telescopic rod is fixedly installed on the inner wall of the guide groove, and the piston end of the telescopic rod is fixedly connected to the lower surface of the guide block. A telescopic spring is movably sleeved on the outer wall of the telescopic rod, and one end of the telescopic spring is fixedly connected to the inner wall of the guide groove, while the other end of the telescopic spring is fixedly connected to the lower surface of the guide block.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0016] 1. By placing the fluid-filled container bottle between two curved clamping plates and driving two sliders to slide towards each other, the two sliders cause the two curved clamping plates and two curved anti-slip pads to move towards each other, so that the inner wall of the two curved anti-slip pads is in close contact with the outer wall of the container bottle. The two curved clamping plates clamp the container bottle through the two curved anti-slip pads, thus facilitating the fixed installation of the container bottle, thereby effectively improving the convenience of installing the container bottle, and making it easier for staff to replace the container bottle later.

[0017] 2. By rotating the rotating rod, the cam rotates. When the cam's protruding position contacts the inner wall of the arc groove, the cam causes the container bottle to descend vertically through the fixed seat and frame plate. As the container bottle descends vertically, the upper end of the insertion needle is inserted into the sealing plug and enters the cavity of the container bottle. The fluid in the container bottle enters the interior of the flow tube through the insertion needle and flows out through the flow tube. At this time, the microfluidic chip reads the fluid velocity and flow rate, thus conveniently realizing the microfluidic control of the fluid and effectively improving the convenience of fluid microfluidics. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the external structure of the fixed outer casing of the present invention.

[0020] Figure 2 This is a schematic diagram of another external structure of the fixed outer casing of the present invention.

[0021] Figure 3 This is a cross-sectional structural diagram of the fixed outer casing of the present invention.

[0022] Figure 4For the present invention Figure 3 Enlarged schematic diagram of part A in the diagram.

[0023] Figure 5 For the present invention Figure 3 Enlarged schematic diagram of part B in the diagram.

[0024] Figure 6 This is a cross-sectional view of the microfluidic chip of the present invention.

[0025] Figure 7 This is a schematic diagram of the cross-sectional structure of the frame plate of the present invention.

[0026] In the diagram: 1. Fixed outer casing; 11. Microfluidic chip; 12. Door panel; 13. Handle; 14. Viewing window; 15. Through groove; 16. Frame plate; 2. Container bottle; 21. Sealing plug; 3. Flow assembly; 31. Insertion pin; 32. Flow tube; 33. Plug; 4. Disassembly and assembly mechanism; 41. Arc-shaped clamping plate; 42. Arc-shaped anti-slip pad; 43. Slide groove; 44. Slider; 45. Double-ended screw; 46. Handle; 5. Pressing mechanism; 51. Rotating rod; 52. Cam; 53. Fixed seat; 54. Arc-shaped groove; 55. Servo motor; 56. Fixed block; 57. Guide groove; 58. Guide block; 59. Fixed rod; 6. Telescopic rod; 61. Telescopic spring. Detailed Implementation

[0027] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0028] Example: Figure 1-7 As shown, the present invention provides a microfluidic device for realizing the switching of valves, including a fixed outer casing 1, a microfluidic chip 11 fixedly installed on the lower surface of the fixed outer casing 1, a door panel 12 rotatably installed on one side of the fixed outer casing 1, and by opening the door panel 12, it is convenient for the operator to place the container bottle 2 inside the fixed outer casing 1. The fixed outer casing 1 is provided with a frame plate 16, and the container bottle 2 is detachably installed on the lower surface of the frame plate 16. The container bottle 2 can be injected with fluid for microfluidics. A sealing plug 21 is movably inserted into the end of the container bottle 2 away from the frame plate 16. The surface of the microfluidic chip 11 is provided with a flow component 3. The surface of the frame plate 16 is provided with a disassembly and assembly mechanism 4 for disassembling and assembling the container bottle 2. The fixed outer casing 1 is provided with a pressing mechanism 5 for pressing the container bottle 2.

[0029] By adopting the above technical solution, and by setting the flow component 3, the flow component 3 facilitates the flow of fluid, thereby facilitating subsequent microfluidic control of the fluid. After the container bottle 2 filled with fluid is placed inside the fixed outer box 1, the disassembly and assembly mechanism 4 is set to facilitate the installation and disassembly of the container bottle 2, thereby making it convenient for staff to replace the container bottle 2. By setting the pressing mechanism 5, the pressing mechanism 5 presses the container bottle 2 through the frame plate 16, causing the container bottle 2 to rise and fall vertically, thereby facilitating the microfluidic control of the fluid and improving the convenience of fluid microfluidic control.

[0030] A handle 13 is fixedly installed on one side of the door panel 12, and a viewing window 14 is also fixedly installed on one side of the door panel 12. A through groove 15 is opened on the other side of the fixed outer box 1.

[0031] By adopting the above technical solution, the door panel 12 can be opened by pulling the handle 13, making it convenient for staff to place the container bottle 2 inside the fixed outer box 1. By setting the viewing window 14, it is convenient for staff to observe the operation inside the fixed outer box 1.

[0032] The flow component 3 includes a connector 31, one end of which is fixedly connected to the upper surface of the microfluidic chip 11. A flow tube 32 is fixedly installed inside the microfluidic chip 11, and the end of the connector 31 near the microfluidic chip 11 is fixedly connected to the flow tube 32.

[0033] By adopting the above technical solution, when the insertion needle 31 is inserted into the interior of the sealing plug 21, the fluid in the container bottle 2 enters the interior of the flow tube 32 through the insertion needle 31 and flows out. The microfluidic chip 11 reads the flow rate and velocity of the fluid.

[0034] One end of the flow tube 32 is movably connected to a plug 33.

[0035] By adopting the above technical solution and setting the plug 33, it is easy to seal the end of the flow pipe 32.

[0036] The disassembly and assembly mechanism 4 includes two arc-shaped clamping plates 41. Arc-shaped anti-slip pads 42 are fixedly installed on the inner walls of the two arc-shaped clamping plates 41. The inner walls of the two arc-shaped anti-slip pads 42 are in contact with the outer wall of the container bottle 2. By setting the arc-shaped anti-slip pads 42, the stability of the clamped container bottle 2 is improved. A sliding groove 43 is provided on the lower surface of the frame plate 16. Two sliders 44 are slidably connected to the inner wall of the sliding groove 43. The lower surface of one slider 44 is fixedly connected to the upper surface of an arc-shaped clamping plate 41.

[0037] By adopting the above technical solution, when the container bottle 2 is placed between the two arc-shaped clamping plates 41, the two sliders 44 slide towards each other along the inner wall of the slide groove 43. The two sliders 44 cause the two arc-shaped clamping plates 41 and the two arc-shaped anti-slip pads 42 to move towards each other. The two arc-shaped clamping plates 41 clamp the container bottle 2 through the two arc-shaped anti-slip pads 42, thereby achieving the fixed installation of the container bottle 2.

[0038] A double-ended screw 45 is rotatably mounted on one side of the frame plate 16. The double-ended screw 45 passes through the slide groove 43 and is threadedly connected to two sliders 44. One end of the double-ended screw 45 passes through the through groove 15. By opening the through groove 15, when the frame plate 16 is vertically raised and lowered, the double-ended screw 45 rises and falls vertically along the inner wall of the through groove 15. A handle 46 is fixedly mounted on one end of the double-ended screw 45.

[0039] By adopting the above technical solution, the double-ended screw 45 is rotated by the knob handle 46, and the double-ended screw 45 drives the two sliders 44 to slide towards each other or away from each other along the inner wall of the slide groove 43.

[0040] The pressing mechanism 5 includes a rotating rod 51, which is rotatably connected to one side of the fixed outer box 1. A cam 52 is fixedly installed at one end of the rotating rod 51. A fixed seat 53 is fixedly installed on the upper surface of the frame plate 16. An arc groove 54 is opened on the side of the fixed seat 53 away from the frame plate 16. The cam 52 and the arc groove 54 are vertically aligned. By opening the arc groove 54, the protruding position of the cam 52 can push the fixed seat 53 downward.

[0041] By adopting the above technical solution, the rotating rod 51 is rotated, which in turn causes the cam 52 to rotate. When the protruding position of the cam 52 contacts the inner wall of the arc groove 54, the cam 52 causes the frame plate 16 to descend vertically through the fixed seat 53. The frame plate 16 causes the container bottle 2 to descend vertically. When the sealing plug 21 at the lower end of the container bottle 2 contacts the insertion needle 31, the upper end of the insertion needle 31 inserts into the sealing plug 21 and enters the interior of the container bottle 2. The fluid in the container bottle 2 enters the interior of the flow pipe 32 through the insertion needle 31.

[0042] A servo motor 55 is fixedly mounted on one side of the fixed outer casing 1, and the end of the rotating rod 51 away from the cam 52 is fixedly connected to the drive output end of the servo motor 55.

[0043] By adopting the above technical solution, the servo motor 55 is turned on, and the drive shaft of the servo motor 55 causes the rotating rod 51 to rotate.

[0044] A fixing block 56 is fixedly installed on the outer wall of the servo motor 55, and one side of the fixing block 56 is fixedly connected to one side of the fixed outer casing 1.

[0045] By adopting the above technical solution, and by setting a fixing block 56, the servo motor 55 is supported and fixed, thereby improving the stability of the servo motor 55.

[0046] The inner wall of the fixed outer casing 1 is provided with evenly distributed guide grooves 57. A guide block 58 is slidably connected to the inner wall of the guide groove 57. A fixed rod 59 is fixedly installed on one side of the guide block 58. The end of the fixed rod 59 away from the guide block 58 is fixedly connected to the lower surface of the frame plate 16. A telescopic rod 6 is fixedly installed on the inner wall of the guide groove 57. The piston end of the telescopic rod 6 is fixedly connected to the lower surface of the guide block 58. A telescopic spring 61 is movably sleeved on the outer wall of the telescopic rod 6. One end of the telescopic spring 61 is fixedly connected to the inner wall of the guide groove 57, and the other end of the telescopic spring 61 is fixedly connected to the lower surface of the guide block 58.

[0047] By adopting the above technical solution, when the frame plate 16 descends vertically, the frame plate 16 causes the guide block 58 to slide vertically downward along the inner wall of the guide groove 57 via the fixing rod 59. The guide block 58 causes the telescopic rod 6 and the telescopic spring 61 to retract. When the protruding position of the cam 52 disengages from the inner wall of the arc groove 54, the telescopic rod 6 and the telescopic spring 61 extend. The extension of the telescopic rod 6 and the telescopic spring 61 causes the guide block 58 to slide vertically upward along the inner wall of the guide groove 57. The guide block 58 causes the frame plate 16 and the container bottle 2 to rise via the fixing rod 59, causing the insertion needle 31 to disengage from the sealing plug 21, thereby realizing microfluidic control of the fluid.

[0048] Working principle: In use, the operator first pulls the handle 13 to open the door panel 12, places the container bottle 2 filled with fluid on the lower surface of the frame plate 16, and the container bottle 2 is between the two arc-shaped clamping plates 41. Then, the operator turns the knob handle 46, which causes the double-headed screw 45 to rotate. As the double-headed screw 45 rotates, the two sliders 44 slide towards each other along the inner wall of the slide groove 43. The two sliders 44 cause the two arc-shaped clamping plates 41 and the two arc-shaped anti-slip pads 42 to move towards each other until the inner wall of the two arc-shaped anti-slip pads 42 is in close contact with the outer wall of the container bottle 2. Then, the operator stops turning the knob handle 46. At this time, the two arc-shaped clamping plates 41 clamp the container bottle 2 on the lower surface of the frame plate 16 through the two arc-shaped anti-slip pads 42, thus facilitating the fixed installation of the container bottle 2 and effectively improving the convenience of installing the container bottle 2. It also makes it easier for the operator to replace the container bottle 2 later.

[0049] Subsequently, the staff turned on the servo motor 55. The drive shaft of the servo motor 55 caused the rotating rod 51 to rotate, which in turn caused the cam 52 to rotate. When the protruding position of the cam 52 contacted the inner wall of the arc groove 54, the cam 52 pushed the fixed seat 53 to descend vertically. The fixed seat 53 caused the fixed container bottle 2 to descend vertically through the frame plate 16. At the same time, the frame plate 16 caused the four guide blocks 58 to slide vertically downward along the inner wall of the corresponding guide groove 57 through the four fixed rods 59. The four guide blocks 58 caused the four telescopic rods 6 and the four telescopic springs 61 to retract. As the container bottle 2 descended vertically, the upper end of the insertion needle 31 was inserted into the sealing plug 21 and entered the cavity of the container bottle 2. The fluid in the container bottle 2 entered the interior of the flow tube 32 through the insertion needle 31 and flowed out through the flow tube 32. At this time, the microfluidic chip 11 read the flow rate and flow rate of the fluid, thus conveniently realizing the microfluidic control of the fluid and effectively improving the convenience of fluid microfluidic control.

[0050] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A microfluidic device for implementing a switch valve, comprising a fixed outer box (1), characterized in that: A microfluidic chip (11) is fixedly mounted on the lower surface of the fixed outer casing (1). A door panel (12) is rotatably mounted on one side of the fixed outer casing (1). A frame plate (16) is provided inside the fixed outer casing (1). A container bottle (2) is detachably mounted on the lower surface of the frame plate (16). A sealing plug (21) is movably inserted into the end of the container bottle (2) away from the frame plate (16). A flow assembly (3) is provided on the surface of the microfluidic chip (11). A disassembly and assembly mechanism for disassembling and assembling the container bottle (2) is provided on the surface of the frame plate (16). Structure (4), the interior of the fixed outer box (1) is provided with a pressing mechanism (5) for pressing the container bottle (2), the pressing mechanism (5) includes a rotating rod (51), the rotating rod (51) is rotatably connected to one side of the fixed outer box (1), a cam (52) is fixedly installed at one end of the rotating rod (51), a fixed seat (53) is fixedly installed on the upper surface of the frame plate (16), and an arc groove (54) is opened on the side of the fixed seat (53) away from the frame plate (16), the cam (52) and the arc groove (54) are vertically corresponding; A handle (13) is fixedly installed on one side of the door panel (12), and a viewing window (14) is also fixedly installed on one side of the door panel (12). A through groove (15) is opened on the other side of the fixed outer box (1). The flow component (3) includes a plug-in pin (31). One end of the plug-in pin (31) is fixedly connected to the upper surface of the microfluidic chip (11). A flow tube (32) is fixedly installed inside the microfluidic chip (11). The end of the plug-in pin (31) near the microfluidic chip (11) is fixedly connected to the flow tube (32). The disassembly and assembly mechanism (4) includes two arc-shaped clamping plates (41). The inner walls of the two arc-shaped clamping plates (41) are fixedly equipped with arc-shaped anti-slip pads (42). The inner walls of the two arc-shaped anti-slip pads (42) are in contact with the outer wall of the container bottle (2). The lower surface of the frame plate (16) is provided with a sliding groove (43). The inner wall of the sliding groove (43) is slidably connected to two sliders (44). The lower surface of one slider (44) is fixedly connected to the upper surface of an arc-shaped clamping plate (41). A double-headed screw (45) is rotatably installed on one side of the frame plate (16). The double-headed screw (45) passes through the sliding groove (43) and is rotatably connected to the two sliders (44) by threads. One end of the double-headed screw (45) passes through the through groove (15). A handle (46) is fixedly installed on one end of the double-headed screw (45). The inner wall of the fixed outer box (1) is provided with evenly distributed guide grooves (57). A guide block (58) is slidably connected to the inner wall of the guide groove (57). A fixed rod (59) is fixedly installed on one side of the guide block (58). The end of the fixed rod (59) away from the guide block (58) is fixedly connected to the lower surface of the frame plate (16). A telescopic rod (6) is fixedly installed on the inner wall of the guide groove (57). The piston end of the telescopic rod (6) is fixedly connected to the lower surface of the guide block (58). A telescopic spring (61) is movably sleeved on the outer wall of the telescopic rod (6). One end of the telescopic spring (61) is fixedly connected to the inner wall of the guide groove (57). The other end of the telescopic spring (61) is fixedly connected to the lower surface of the guide block (58).

2. The microfluidic device for realizing the switching of valves as described in claim 1, characterized in that, A plug (33) is movably inserted into one end of the flow tube (32).

3. The microfluidic device for realizing the switching of valves as described in claim 2, characterized in that, A servo motor (55) is fixedly mounted on one side of the fixed outer casing (1), and the end of the rotating rod (51) away from the cam (52) is fixedly connected to the drive output end of the servo motor (55).

4. The microfluidic device for realizing the switching of valves as described in claim 3, characterized in that, A fixing block (56) is fixedly installed on the outer wall of the servo motor (55), and one side of the fixing block (56) is fixedly connected to one side of the fixed outer box (1).

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