A device and method for calibrating a multi-physiological parameter detection instrument

Abstract

The application discloses a device and method for calibrating a multi-physiological parameter detection instrument. The device comprises an electromagnetic wave source, a control module, an electromagnetic wave uniform module, an electromagnetic wave detection module, a mirror, a functional template and a lens. The electromagnetic wave uniform module is provided with an incident hole and an exit hole. The electromagnetic wave source is connected with the control module, and is used for incidenting electromagnetic waves into the electromagnetic wave uniform module. The mirror, the functional template and the lens are arranged outside the exit hole. The electromagnetic wave detection module is used for sending corresponding generated electric signals to the control module after detecting target electromagnetic wave signals. The mirror is used for adjusting the propagation direction of the exit electromagnetic waves. The functional template and the lens are used for receiving the exit electromagnetic waves and emitting the exit electromagnetic waves to the light receivers of the equipment to be calibrated. The application has the advantages of simple structure, stable performance, convenient assembly with different modules, calibration of different electromagnetic wave detection equipment, and improvement of the development efficiency and performance of the equipment.

Description

TECHNICAL FIELD

[0001] Embodiments of the present application relate to the field of biomedical technology, and in particular to a device and method for calibrating a multi-physiological parameter detection instrument. BACKGROUND

[0002] Glucose, hemoglobin, fat, melanin, bilirubin and other substances in the human body have different interaction intensities with electromagnetic waves of different frequencies. The detection principle based on electromagnetic waves is as follows: electromagnetic waves are incident on the tissue, and after interaction such as absorption and scattering by tissues including blood vessels, fat, etc., they are captured by a sensor. Based on the electromagnetic spectrum obtained by the sensor, some physiological and pathological parameters can be calculated, such as heart rate, blood oxygen saturation, blood glucose, blood lipids, etc.

[0003] For example, a heart rate and blood oxygen saturation tester based on electromagnetic waves: the obtained spectrum information can be divided into non-pulsatile components (mainly caused by absorption of tissue, bone and other components) and pulsatile components (mainly caused by absorption of hemoglobin in arterial blood). In addition, there are obvious differences in the absorption of light by arterial blood at different oxygen saturation levels. According to a specific algorithm, the obtained spectrum can be processed to monitor dynamic heart rate and blood oxygen saturation. By similar methods, based on electromagnetic waves of different frequencies, in combination with transmission equipment and sensors, monitoring of important physiological parameters such as tissue blood glucose, blood lipids and metabolic rate can be achieved. By propagating electromagnetic waves, in combination with transmission equipment and sensors, monitoring of different physiological parameters can be achieved. Due to individual differences in the human body, in order to assist the development of non-invasive physiological parameter (such as heart rate, blood oxygen, blood glucose and blood lipids) detection instruments based on electromagnetic waves, a standard device is needed to simulate the absorption and scattering process of different components of the tissue to the electromagnetic waves to calibrate and calibrate these instruments.

[0004] Common methods can be roughly divided into the following categories: human average or empirical value calibration method, tissue fluid circulation simulation system and tissue phantom. The method based on human average and experience is easily affected by individual differences and cannot simulate physiological parameters outside the normal human variation range. The method based on the tissue fluid circulation simulation system also has similar problems, and also has problems such as short useable period and poor portability. The tissue phantom that can simulate the absorption of tissue to electromagnetic waves is an option recognized by academia and the business community, but the preparation process of the phantom that can simulate multiple physiological parameters has high requirements and still has the problem of poor practicality. The calibration method based on electronic simulator can simulate physiological parameters in any range; however, most of these devices only have a single function, have unstable performance or poor signal uniformity, and still have some gaps from real tissue. SUMMARY

[0005] In order to solve the problems in the prior art, the application provides a device and a method for calibrating a multi-physiological parameter detection instrument to assist in the development and calibration of an electromagnetic wave-based physiological parameter detection instrument.

[0006] In a first aspect, the embodiments of the application provide a device for calibrating a multi-physiological parameter detection instrument, comprising: an electromagnetic wave source, a control module, an electromagnetic wave uniformity module, an electromagnetic wave detection module, a mirror, a functional template, and a lens.

[0007] The electromagnetic wave uniformity module is provided with an incident hole and an exit hole for uniform incident electromagnetic waves.

[0008] The electromagnetic wave source is connected to the control module, and the electromagnetic wave source is arranged outside the incident hole to emit electromagnetic waves into the electromagnetic wave uniformity module through the incident hole.

[0009] The electromagnetic wave detection module is connected to the control module, and the electromagnetic wave detection module sends the corresponding generated electrical signal to the control module after detecting the target electromagnetic wave signal, so that the control module controls the electromagnetic wave source to emit corresponding electromagnetic waves.

[0010] The mirror, the functional template, and the lens are arranged outside the exit hole.

[0011] The mirror is used to adjust the propagation direction of the electromagnetic waves emitted by the electromagnetic wave uniformity module, so that the electromagnetic waves are irradiated onto the light receiver of the device to be calibrated; the functional template and the lens are used to receive the electromagnetic waves emitted by the exit hole and emit the electromagnetic waves to the light receiver of the device to be calibrated.

[0012] Optionally, the electromagnetic wave uniformity module is a cavity with a diffuse reflection material coated on the inner wall.

[0013] Optionally, the electromagnetic wave uniformity module is provided with at least two exit holes.

[0014] Optionally, the electromagnetic wave source has a generator and a driving module, and the driving module is used to receive the control signal transmitted by the control module and drive the generator to emit electromagnetic waves into the electromagnetic wave uniformity module.

[0015] Optionally, the shape of the mirror is prepared according to the device to be calibrated.

[0016] Optionally, the exit hole of the electromagnetic wave uniformity module is further provided with a phantom or a functional module for simulating different tissues.

[0017] In a second aspect, the embodiments of the present application also provide a method for calibrating a multi-physiological parameter detection instrument, which is implemented based on the device in any of the above embodiments, and comprises the following steps:

[0018] According to the physiological parameter corresponding to the device to be calibrated, relevant parameters in the control module are set;

[0019] The electromagnetic wave wavelength and amplitude emitted by the device to be calibrated are detected by the electromagnetic wave detection module;

[0020] The electromagnetic wave detection module generates a corresponding electrical signal according to the electromagnetic wave wavelength and amplitude and transmits the electrical signal to the control module;

[0021] The control module calculates an output signal according to the received electrical signal and controls the electromagnetic wave source to emit corresponding electromagnetic waves;

[0022] After the electromagnetic waves emitted by the electromagnetic wave source are incident into the electromagnetic wave uniform device, the electromagnetic waves are emitted through the exit hole, and the electromagnetic waves are emitted onto the receiver of the device to be calibrated by the mirror or functional template and lens, so that the device to be calibrated is calibrated.

[0023] The present application has the following advantages:

[0024] 1. The device provided by the embodiments of the present application is entirely solid, simple in structure, easy to mass-produce, convenient to operate, good in portability, and easy to popularize.

[0025] 2. The appearance of the main device can be conveniently adjusted to switch functions, and can meet the requirements of different physiological parameter detection instruments.

[0026] 3. The device integrates simulation of different physiological parameters such as tissue blood oxygen and heart rate, and has stable performance and high repeatability.

[0027] 4. The device can be made and assembled with different parameters for different types of tissues, so that its application range is wider.

[0028] 5. The electromagnetic wave uniform module of the device can be any device that can uniformly distribute electromagnetic waves, can control the loss of incident electromagnetic waves and the exit intensity, and can be used to calibrate any type of reflective and transmissive multi-physiological parameter detection instrument by setting a mirror, a functional template and a lens at the exit. BRIEF DESCRIPTION OF DRAWINGS

[0029] Figure 1 A device structure diagram for calibrating a multi-physiological parameter detection instrument is provided for the embodiments of the present application;

[0030] Figure 2 A method flowchart for calibrating a multi-physiological parameter detection instrument is provided for the embodiments of the present application;

[0031] Figure 3 A schematic diagram of a wrist-shaped calibration device structure is provided for the embodiment of the present application.

[0032] Figure 4 A schematic diagram of a finger-shaped calibration device structure is provided for the embodiment of the present application.

[0033] Figure 5 A schematic diagram of a fundus camera calibration device structure is provided for the embodiment of the present application.

[0034] Among them, the electromagnetic wave source-1, the control module-2, the electromagnetic wave detection module-3, the phantom-4, the mirror-5, the electromagnetic wave uniform module-6, the functional template-7, the lens-8, the wrist-shaped phantom with supporting function-9, the finger-shaped phantom with specific supporting function-10, the lens barrel-11. DETAILED DESCRIPTION

[0035] The present application will be further described below in conjunction with the drawings and embodiments. It can be understood that the specific embodiments described herein are only used to explain the present application, but not to limit the present application. In addition, it should be noted that, for the convenience of description, only the parts related to the present application are shown in the drawings, but not all the structures.

[0036] EMBODIMENT

[0037] Figure 1 A device for calibrating a multi-physiological parameter detection instrument is provided for the embodiment of the present application, comprising: an electromagnetic wave source 1, a control module 2, an electromagnetic wave detection module 3, a mirror 5, an electromagnetic wave uniform module 6, a functional template 7 and a lens 8, wherein the lens 8 is also provided with an electromagnetic wave detection module.

[0038] Among them, the electromagnetic wave uniform module can be any device that makes the electromagnetic wave uniformly distributed, which is provided with an incident hole and an exit hole, and is a cavity with a diffuse reflection material on the inner wall, which is used for uniformly incident electromagnetic wave, and controls the loss of incident electromagnetic wave and its exit intensity, and improves the uniformity of the signal.

[0039] Further, the incident port of the electromagnetic wave uniform module is provided with an electromagnetic wave source, which is connected with the control module, and is used for incidenting the electromagnetic wave into the inside of the electromagnetic wave uniform module through the incident hole. The electromagnetic wave emitted from the exit port of the electromagnetic wave source can be incidented into the inside of the electromagnetic wave uniform module through the incident hole of the electromagnetic wave uniform module.

[0040] Specifically, the electromagnetic wave source has a generating device and a driving module, the driving module is used for receiving the control signal transmitted by the control module, and driving the generating device to emit electromagnetic wave into the inside of the electromagnetic wave uniform module. The electromagnetic wave entering the electromagnetic wave uniform module is reflected multiple times on the inner wall coating, and forms uniform illumination on the inner wall. The exit hole emits exit electromagnetic wave with high uniformity.

[0041] Further, the electromagnetic wave detection module is connected with the control module, and the mirror, the functional template and the lens are arranged outside the exit hole.

[0042] The electromagnetic wave detection module is used for detecting whether the target electromagnetic wave (such as red light and infrared light) is irradiated at present, and the intensity of the target electromagnetic wave, simultaneously generating an electric signal and transmitting the electric signal to the control module.

[0043] The control module is used for receiving the signal transmitted by the electromagnetic wave detection module, analyzing the received signal, and calculating a corresponding control signal for triggering the electromagnetic wave source to emit electromagnetic waves.

[0044] Due to the difference of the equipment to be calibrated, the propagation direction of the electromagnetic wave emitted by the electromagnetic wave uniformity module is also different. In the embodiment, not only the mirror is arranged outside the exit hole to adjust the propagation direction of the emitted electromagnetic wave, but also the functional template and the lens are arranged outside the exit hole to transmit the emitted electromagnetic wave whose propagation direction does not need to be changed, so as to meet the calibration of various types of equipment to be detected. The mirror is used for adjusting the propagation direction of the electromagnetic wave emitted by the electromagnetic wave uniformity module, so that the electromagnetic wave is irradiated on the light receiver of the equipment to be calibrated. The functional template and the lens are used for receiving the electromagnetic wave emitted by the exit hole and emitting the electromagnetic wave to the light receiver of the equipment to be calibrated. The above functional module can simulate the interaction of electromagnetic waves of any wave band with different tissues, so as to meet the requirements of different detection instruments.

[0045] Further, the propagation direction of the emitted electromagnetic wave can be adjusted by the mirror, so that the emitted electromagnetic wave is vertically irradiated on the receiver of the equipment to be calibrated, such as a finger clamp type detection device, a wristband type, and a tissue surface paste type device. For part of the target calibration equipment which does not need to change the propagation direction of the electromagnetic wave, such as the equipment for detecting physiological parameters through the eye part, the emitted electromagnetic wave needs to pass through the functional mask template and the lens of different shapes (such as the retinal blood vessels of the fundus) and finally reaches the receiver of the equipment to be calibrated.

[0046] Further, before the reflected electromagnetic wave reaches the light receiver of the equipment to be calibrated, the phantom 4 simulating tissue absorption and scattering or the functional module can be added to more realistically simulate the interaction of electromagnetic waves and tissues. The phantom and the functional module in the embodiment can adapt to the physiological functions of tissues in any part, and can meet the calibration of different physiological parameter detection equipment.

[0047] In practical application, the terminal of the mirror in the embodiment can be prepared into different shapes to meet the calibration of different types of equipment, such as wrist shape, finger shape and retinal shape. The module with the phantom function can also be integrated into the wrist shape, finger shape and retinal shape structure.

[0048] See further Figure 2 The present invention also provides a method for calibrating a multi-physiological parameter detection instrument, implemented based on the apparatus described in any one of the above embodiments, comprising:

[0049] S1. Set the relevant parameters in the control module according to the physiological parameters of the device to be calibrated;

[0050] S2. The electromagnetic wave wavelength and amplitude emitted by the device to be calibrated are detected by the electromagnetic wave detection module.

[0051] S3. The electromagnetic wave detection module generates a corresponding electrical signal based on the wavelength and amplitude of the electromagnetic wave and transmits it to the control module.

[0052] S4. The control module calculates the output signal based on the received electrical signal and controls the electromagnetic wave source to emit corresponding electromagnetic waves.

[0053] S5. Electromagnetic waves emitted by the electromagnetic wave source are incident on the electromagnetic wave homogenizing device and then exit through the exit hole. A reflector or functional template and lens direct the electromagnetic waves to the receiver of the device to be calibrated, thereby calibrating the device. The technical solution of this embodiment allows for convenient adjustment of the device layout according to the calibration requirements of transmissive or reflective devices.

[0054] See examples Figure 3 , Figure 3 This includes a wrist-shaped phantom 9 with support function and its cross-sectional view. When the device to be calibrated is a wristband used for blood oxygen saturation detection, the corresponding calibration procedure is as follows:

[0055] 1) Complete the assembly with the wrist-shaped phantom to form a digital phantom used to assist in the development of a blood oxygen saturation detection wristband.

[0056] 2) Set the relevant parameters of the control module according to the required simulated heart rate and blood oxygen saturation.

[0057] 3) Place the blood oxygen saturation detector in the middle area of ​​the wrist-shaped phantom on the device. The detector needs to completely cover the electromagnetic wave detection module. The position of the reflector and the area with the phantom function can be changed according to the needs of the detection module.

[0058] 4) Turn on the blood oxygen saturation bracelet. The bracelet will emit periodic red and infrared light.

[0059] 5) Then the electromagnetic wave detection module detects the intensity of red light and infrared light respectively, and generates corresponding electrical signals to be transmitted to the control module.

[0060] 6) The control module analyzes and processes the received electrical signals, calculates the output signal, and controls the electromagnetic wave source to emit corresponding electromagnetic waves.

[0061] 7) The light signal emitted by the electromagnetic wave source enters the electromagnetic wave homogenizing module through the entrance hole. After multiple reflections, it shines onto the reflector through the exit hole. The reflector adjusts the propagation direction of the electromagnetic wave, ensuring that the emitted electromagnetic wave perpendicularly illuminates the light receiver of the blood oxygen detection wristband, thereby calibrating the wristband. For example, the electromagnetic wave homogenizing module in this embodiment can be configured as an integrating sphere.

[0062] See examples Figure 4 , Figure 4 The document includes a finger-shaped phantom 10 with specific supporting functions and its cross-sectional view. When the device to be calibrated is an instrument used to assist in fingertip transmissive pulse oximetry, the corresponding calibration procedure is as follows:

[0063] 1) Complete the assembly with the finger-shaped phantom to form a digital phantom used to assist in the development of a fingertip transmissive blood oxygen saturation detection instrument.

[0064] 2) Set the relevant parameters of the control module according to the required simulated heart rate and blood oxygen saturation.

[0065] 3) Place the blood oxygen saturation detector in the middle area of ​​the finger-shaped phantom on the device. The detector needs to completely cover the electromagnetic wave detection module and the reflector. The position of the reflector and the area with the phantom function can be changed according to the needs of the detection module.

[0066] 4) Turn on the blood oxygen saturation detector, which emits periodic red and infrared light.

[0067] 5) Then the electromagnetic wave detection module detects the intensity of red light and infrared light respectively, and generates corresponding electrical signals to be transmitted to the control module.

[0068] 6) The control module analyzes and processes the received electrical signals, calculates the output signal, and controls the electromagnetic wave source to emit corresponding electromagnetic waves.

[0069] 7) The electromagnetic waves emitted by the electromagnetic wave source enter the electromagnetic wave uniform module through the entrance hole. After multiple reflections, they shine onto the reflector through the exit hole. The reflector adjusts the propagation direction of the electromagnetic waves so that the emitted electromagnetic waves shine perpendicularly onto the light receiver of the pulse oximeter, thereby calibrating the fingertip transmissive pulse oximeter.

[0070] See examples Figure 5 , Figure 5 This includes a cross-sectional view of the lens barrel 11, phantom, functional template, lens, and electromagnetic wave detection module. When the device to be calibrated is a fundus camera, the corresponding calibration procedure is as follows:

[0071] 1) Complete the assembly with the retinal mask, phantom (optional) and lens to form a digital phantom for use in the development of a reflective fundus camera blood oxygenation detection device.

[0072] 2) Set the relevant parameters of the control module according to the blood oxygen saturation to be simulated.

[0073] 3) Place the reflective fundus camera blood oxygenation detection device in the middle area of ​​the retinal phantom on the device. The detection instrument needs to completely cover the electromagnetic wave detection module and lens.

[0074] 4) Turn on the reflective fundus camera blood oxygenation detection device, which emits periodic red and infrared light.

[0075] 5) Then the electromagnetic wave detection module detects the intensity of red light and infrared light respectively, and generates corresponding electrical signals to be transmitted to the control module.

[0076] 6) The control module analyzes and processes the received electrical signals, calculates the output signal, and controls the electromagnetic wave source to emit corresponding electromagnetic waves.

[0077] 7) The electromagnetic waves emitted by the electromagnetic wave source enter the electromagnetic wave uniform module through the entrance hole. After multiple reflections, they are emitted through the exit hole and lens and then irradiated onto the light receiver of the fundus camera blood oxygen detection device, thereby calibrating the fundus camera.

[0078] Note that the above description is merely a preferred embodiment of the present invention and the technical principles employed. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein, and various obvious changes, readjustments, and substitutions can be made without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in detail through the above embodiments, the present invention is not limited to the above embodiments, and may include many other equivalent embodiments without departing from the concept of the present invention, the scope of which is determined by the scope of the appended claims.

Claims

1. A device for calibrating a multi-physiological parameter detection instrument, characterized in that, The device comprises an electromagnetic wave source, a control module, an electromagnetic wave uniformity module, an electromagnetic wave detection module, a mirror, a functional template and a lens. The electromagnetic wave uniformity module is provided with an incident hole and an exit hole for uniform incident electromagnetic waves. The electromagnetic wave uniformity module is provided with at least one exit hole. The method for calibrating a multi-physiological parameter detection instrument comprises: According to the physiological parameters corresponding to the device to be calibrated, the relevant parameters in the control module are set; The electromagnetic wave detection module detects the wavelength and amplitude of the electromagnetic waves emitted by the device to be calibrated; The electromagnetic wave detection module generates corresponding electrical signals according to the wavelength and amplitude of the electromagnetic waves and transmits them to the control module; The control module calculates the output signal according to the received electrical signals and controls the electromagnetic wave source to emit corresponding electromagnetic waves; The electromagnetic waves emitted by the electromagnetic wave source are incident into the electromagnetic wave uniformity device and then exit through the exit hole, and the mirror or the functional template and the lens emit the electromagnetic waves to the receiver of the device to be calibrated, thereby calibrating the device to be calibrated. The electromagnetic wave detection module and the control module are connected, and the corresponding electrical signals are sent to the control module after the target electromagnetic wave signal is detected, so as to control the electromagnetic wave source to emit corresponding electromagnetic waves through the control module. The mirror, the functional template and the lens are arranged outside the exit hole. The mirror is used to adjust the propagation direction of the electromagnetic waves emitted by the electromagnetic wave uniformity module so as to irradiate the light receiver of the device to be calibrated; and the functional template and the lens are used to receive the electromagnetic waves emitted by the exit hole and emit them to the light receiver of the device to be calibrated. The electromagnetic wave uniformity module is a cavity with a diffuse reflection material coated on the inner wall.

2. The apparatus of claim 1, wherein, The electromagnetic wave source has a generator and a driving module, and the driving module is used to receive the control signals transmitted by the control module and drive the generator to emit electromagnetic waves into the electromagnetic wave uniformity module.

3. The apparatus of claim 1, wherein, The shape of the mirror is prepared according to the device to be calibrated.

4. The apparatus of claim 1, wherein, The exit hole of the electromagnetic wave uniformity module is further provided with a phantom or a functional module for simulating different tissues.

5. The apparatus of claim 1, wherein, 6. A method for calibrating a multi-physiological parameter detection instrument, which is implemented based on the device according to any one of claims 1-5, and comprises: According to the physiological parameters corresponding to the device to be calibrated, the relevant parameters in the control module are set; The electromagnetic wave detection module detects the wavelength and amplitude of the electromagnetic waves emitted by the device to be calibrated; The electromagnetic wave detection module generates corresponding electrical signals according to the wavelength and amplitude of the electromagnetic waves and transmits them to the control module; The control module calculates the output signal according to the received electrical signals and controls the electromagnetic wave source to emit corresponding electromagnetic waves; The electromagnetic waves emitted by the electromagnetic wave source are incident into the electromagnetic wave uniformity device and then exit through the exit hole, and the mirror or the functional template and the lens emit the electromagnetic waves to the receiver of the device to be calibrated, thereby calibrating the device to be calibrated. ​

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