Transorbital electrical stimulation device

Abstract

The present invention provides a trans-orbital electrical stimulation device, which relates to the field of electronic technology. The device includes: an electroencephalogram (EEG) signal collector, a controller, and an electrical stimulation signal generator, wherein: the EEG signal collector is connected to the controller, and is used to collect the patient's eyes-closed resting-state EEG signals and eyes-open resting-state EEG signals, and transmit them to the controller; the controller is connected to the electrical stimulation signal generator, and is used to obtain the patient's corresponding target alpha frequency based on the eyes-closed resting-state EEG signals and eyes-open resting-state EEG signals, and transmit it to the electrical stimulation signal generator; the electrical stimulation signal generator is used to generate a first alternating current (AC) stimulation signal based on the patient's corresponding target alpha frequency, and output the first AC stimulation signal to apply electrical stimulation to the patient's eye socket, thereby solving the technical problem in the prior art of how to generate appropriate AC stimulation signals for different patients.

Description

Technical Field

[0001] The present invention relates to the field of electronic technology, and in particular to a trans-orbital electrical stimulation device. Background Art

[0002] Glaucoma is the second leading cause of blindness worldwide. Its primary characteristic is the progressive damage of retinal ganglion cells, accompanied by structural and functional degeneration of the optic nerve head and optic nerve fiber layer, resulting in visual field impairment and decreased vision. Treatment for glaucoma aims to delay further damage to the optic nerve. However, even after treatment stabilizes, rehabilitation methods for the visual impairment caused by glaucoma remain unavailable in my country.

[0003] Currently, transorbital alternating current stimulation (rtACS) is the most promising visual rehabilitation technology internationally. Studies have shown that after multiple days of continuous periocular AC stimulation intervention, visual performance within the impaired visual field of glaucoma patients improved by 59.86%, manifested by improved visual reaction speed and visual acuity. However, clinical research results also show that there is significant individual variability in the response of visually impaired patients to this AC stimulation intervention, with approximately 50% of patients showing no measurable visual improvement after intervention.

[0004] Therefore, how to generate appropriate AC stimulation signals for different patients is a technical problem that needs to be solved urgently by technicians in related fields. Summary of the Invention

[0005] The present invention provides a transorbital electrical stimulation device to solve the defect in the prior art of how to generate appropriate alternating current stimulation signals for different patients.

[0006] The present invention provides a transorbital electrical stimulation device, comprising: an electroencephalogram (EEG) signal collector, a controller, and an electrical stimulation signal generator, wherein:

[0007] The EEG signal collector is connected to the controller and is used to collect the patient's eyes-closed resting state EEG signals and eyes-open resting state EEG signals, and transmit them to the controller;

[0008] The controller is connected to the electrical stimulation signal generator, and is used to obtain the target alpha frequency corresponding to the patient based on the eyes-closed resting-state EEG signal and the eyes-open resting-state EEG signal, and transmit the target alpha frequency to the electrical stimulation signal generator;

[0009] The electrical stimulation signal generator is used to generate a first alternating current stimulation signal based on the target alpha frequency corresponding to the patient, and output the first alternating current stimulation signal to apply electrical stimulation to the patient's eye socket.

[0010] According to the transorbital electrical stimulation device provided by the present invention, the EEG signal collector is also used to collect the patient's eyes-closed resting-state EEG signals and eyes-open resting-state EEG signals through EEG recording electrodes placed on the patient's occipital scalp.

[0011] According to a transorbital electrical stimulation device provided by the present invention, the controller includes a target frequency determination module;

[0012] The target frequency determination module is used to generate an alpha band eyes-closed power spectrum based on the eyes-closed resting-state EEG signal, and to generate an alpha band eyes-open power spectrum based on the eyes-open resting-state EEG signal, and to determine the target alpha frequency corresponding to the patient based on the alpha band eyes-closed power spectrum and the alpha band eyes-open power spectrum.

[0013] According to a transorbital electrical stimulation device provided by the present invention, the target frequency determination module includes:

[0014] an EEG signal processing unit, configured to filter the eyes-closed resting-state EEG signal and the eyes-open resting-state EEG signal, and segment the filtered eyes-closed resting-state EEG signal and the eyes-open resting-state EEG signal to obtain multiple segments of eyes-closed EEG signals and multiple segments of eyes-open EEG signals;

[0015] a power spectrum generating unit, configured to obtain a first power spectrum corresponding to the plurality of segments of eyes-closed EEG signals and a second power spectrum corresponding to the plurality of segments of eyes-open EEG signals, and extract an alpha band eyes-closed power spectrum from the first power spectrum, and extract an alpha band eyes-open power spectrum from the second power spectrum;

[0016] a target frequency determination unit, configured to obtain, based on the alpha band eyes-closed power spectrum and the alpha band eyes-open power spectrum, a power difference between the eyes-closed resting power and the eyes-open resting power corresponding to each alpha frequency point in the alpha band, and determine the alpha frequency point with the highest power difference as the target alpha frequency.

[0017] According to the transorbital electrical stimulation device provided by the present invention, the EEG signal collector is further used to collect a first electrical stimulation EEG signal when the patient's orbit is electrically stimulated by the first alternating current stimulation signal, and transmit the first electrical stimulation EEG signal to the controller;

[0018] The controller is further configured to determine a target AC electrical stimulation intensity corresponding to the patient based on the first electrical stimulation EEG signal, and transmit the target AC electrical stimulation intensity to the electrical stimulation signal generator;

[0019] The electrical stimulation signal generator is further configured to generate a second AC stimulation signal corresponding to the patient based on the target AC stimulation intensity and the target alpha frequency, and output the second AC stimulation signal to apply electrical stimulation to the patient's eye socket.

[0020] According to a trans-orbital electrical stimulation device provided by the present invention, the electrical stimulation signal generator is also used to generate a plurality of first alternating current stimulation signals with different current intensities based on the target alpha frequency and a preset current intensity gradient, and to apply electrical stimulation to the patient's orbit based on the first alternating current stimulation signal of each current intensity through electrical stimulation electrodes placed at the patient's orbit.

[0021] According to the trans-orbital electrical stimulation device provided by the present invention, the EEG signal collector is also used to collect the first electrical stimulation EEG signal of the patient's orbit when it is subjected to the first alternating current stimulation signal of each current intensity through EEG recording electrodes placed on the patient's occipital scalp.

[0022] According to the transorbital electrical stimulation device provided by the present invention, the controller further comprises a stimulation intensity determination module;

[0023] The stimulation intensity determination module is used to determine the target second harmonic signal-to-noise ratio corresponding to the target alpha frequency at each current intensity based on the first electrical stimulation EEG signal corresponding to each current intensity; based on the target second harmonic signal-to-noise ratio corresponding to each current intensity, generate a correspondence curve between the current intensity and the second harmonic signal-to-noise ratio, and determine the target alternating current stimulation intensity corresponding to each preset signal-to-noise ratio based on the corresponding curve.

[0024] According to a transorbital electrical stimulation device provided by the present invention, the stimulation intensity determination module includes:

[0025] an electroencephalogram signal filtering unit, configured to filter the first electroencephalogram signal corresponding to each current intensity to obtain the first electroencephalogram signal corresponding to each current intensity after filtering;

[0026] an EEG signal segmentation unit, configured to segment the first electrical stimulation EEG signal corresponding to each current intensity after filtering, based on a preset segment length and a preset overlap length, to obtain a plurality of segments of electrical stimulation EEG signals;

[0027] an EEG signal superposition unit, configured to superimpose and average multiple segments of electrical stimulation EEG signals corresponding to each current intensity to obtain a second electrical stimulation EEG signal corresponding to each current intensity;

[0028] a target power determination unit, configured to obtain a third power spectrum of the second electrical stimulation EEG signal corresponding to each current intensity, and obtain a target second harmonic power value corresponding to the target alpha frequency at each current intensity based on the third power spectrum;

[0029] a target signal-to-noise ratio determining unit, configured to obtain a target second harmonic signal-to-noise ratio corresponding to the target alpha frequency at each current intensity based on a target second harmonic power value corresponding to the target alpha frequency at each current intensity and a preset average noise power value;

[0030] a stimulation intensity determination unit, configured to perform normalization and curve fitting on the target second harmonic signal-to-noise ratio corresponding to the target alpha frequency at each current intensity, generate a corresponding curve between the current intensity and the second harmonic signal-to-noise ratio, and determine the target alternating current stimulation intensity corresponding to each preset signal-to-noise ratio based on the corresponding curve.

[0031] According to a transorbital electrical stimulation device provided by the present invention, the controller further includes a stimulation output control module, and the stimulation output control module includes:

[0032] a stimulation intensity division unit, configured to divide the target AC stimulation intensities corresponding to the plurality of preset signal-to-noise ratios into target AC stimulation intensities of a first level of intensity and target AC stimulation intensities of a second level of intensity;

[0033] a first output control unit, configured to control the electrical stimulation signal generator during a first electrical stimulation cycle to output the second alternating current electrical stimulation signal based on the target alpha frequency and the target alternating current stimulation intensity of the first level of intensity, so as to apply electrical stimulation to the patient's eye socket;

[0034] The second output control unit is used to control the electrical stimulation signal generator during a second electrical stimulation cycle, and output the second AC electrical stimulation signal based on the target alpha frequency and the target AC electrical stimulation intensity of the second level intensity to apply electrical stimulation to the patient's eye socket.

[0035] The transorbital electrical stimulation device provided by the present invention analyzes the eyes-closed resting-state EEG signals and eyes-open resting-state EEG signals of different patients, thereby determining the target alpha frequency corresponding to each patient based on the analysis results, and then generating a first alternating current stimulation signal that is adapted to the brain discharge rhythm and neural regulation rhythm of each patient based on the target alpha frequency corresponding to each patient, thereby improving the effect of the alternating current stimulation signal on the patient and enhancing the neural regulation effect on the patient's damaged visual pathway, thereby achieving better auxiliary treatment of the patient's vision impairment, and solving the technical problem of how to generate adapted alternating current stimulation signals for different patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced one by one below. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0037] Figure 1 This is one of the structural schematic diagrams of the transorbital electrical stimulation device provided by an embodiment of the present invention;

[0038] Figure 2 This is the second structural schematic diagram of the transorbital electrical stimulation device provided by an embodiment of the present invention;

[0039] Figure 3 is a schematic structural diagram of a target frequency determination module in an embodiment of the present invention;

[0040] Figure 4 Schematic diagram of the working principle of the target frequency determination module in an embodiment of the present invention;

[0041] Figure 5 Schematic diagram of the working principle of the stimulation intensity determination module in an embodiment of the present invention;

[0042] Figure 6 is a structural diagram of a stimulation intensity determination module in an embodiment of the present invention;

[0043] Figure 7 2 is a schematic diagram of the structure of the stimulation output control module in an embodiment of the present invention. DETAILED DESCRIPTION

[0044] To make the objectives, technical solutions, and advantages of the present invention more clear, the technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the embodiments described are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts shall fall within the scope of protection of the present invention.

[0045] like Figure 1 As shown, the present invention provides a transorbital electrical stimulation device 100, comprising: an EEG signal collector 10, a controller 20 and an electrical stimulation signal generator 30, wherein:

[0046] The EEG signal collector 10 is connected to the controller 20 and is used to collect the patient's eyes-closed resting state EEG signals and eyes-open resting state EEG signals, and transmit them to the controller 20 .

[0047] The eyes-closed resting-state EEG signal refers to the patient's resting-state EEG signal with their eyes closed. The eyes-open resting-state EEG signal refers to the patient's resting-state EEG signal with their eyes open. Resting-state EEG signals refer to EEG signals generated when a person is awake, eyes closed, and relaxed. Transorbital means that electrical stimulation is delivered to the area surrounding the patient's eyes.

[0048] The controller 20 is connected to the electrical stimulation signal generator 30 and is configured to obtain the patient's target alpha frequency based on the eyes-closed resting-state EEG signal and the eyes-open resting-state EEG signal and transmit the obtained target alpha frequency to the electrical stimulation signal generator 30. Specifically, the controller 20 is configured to analyze the patient's eyes-closed resting-state EEG signal and the eyes-open resting-state EEG signal and determine the patient's target alpha frequency based on the analysis results.

[0049] The electrical stimulation signal generator 30 is configured to generate a first alternating current stimulation signal based on a target alpha frequency corresponding to the patient, and output the first alternating current stimulation signal to apply electrical stimulation to the patient's eye socket.

[0050] In one embodiment, the electrical stimulation signal generator 30 is further configured to generate a plurality of first AC electrical stimulation signals of different current intensities based on the patient's corresponding target alpha frequency, and output the plurality of first AC electrical stimulation signals of different current intensities to electrically stimulate the patient's eye sockets. Furthermore, the plurality of first AC electrical stimulation signals of different current intensities are sequentially output in order of increasing current intensities to electrically stimulate the patient's eye sockets with gradually increasing current intensities.

[0051] It should be noted that the commonly used frequency of transorbital alternating current stimulation is 8-25 Hz, and the key role is played by the alpha frequency band (7-14 Hz). After multiple days of alternating current stimulation intervention on the patient's orbit, the patient's alpha frequency band power increased, and the functional connectivity between the frontal and occipital lobes within the alpha frequency band increased. This change is associated with improved visual function in patients. Therefore, the current clinical frequency of transorbital alternating current stimulation provided to glaucoma patients is 10 Hz. However, not all patients have an effective alpha frequency of 10 Hz. Differences in brain discharge rhythms and neural regulation rhythms between different patients may cause some patients to only have a weak response to a transorbital alternating current stimulation frequency of 10 Hz.

[0052] Based on this, the present invention provides a transorbital electrical stimulation device 100. By analyzing the eyes-closed resting-state EEG signals and eyes-open resting-state EEG signals of different patients, the device determines the target alpha frequency corresponding to each patient based on the analysis results. Based on the target alpha frequency corresponding to each patient, the device generates a first alternating current (AC) stimulation signal that is adapted to each patient's brain discharge rhythm and neural control rhythm. This improves the effect of the AC stimulation signal on the patient and enhances the neural control effect on the patient's damaged visual pathway, thereby achieving better auxiliary treatment for the patient's vision impairment and solving the technical problem of how to generate an adapted AC stimulation signal for different patients. In one embodiment, the EEG signal collector 10 is further used to collect the patient's eyes-closed resting-state EEG signals and eyes-open resting-state EEG signals using EEG recording electrodes placed on the patient's occipital scalp. The EEG recording electrodes are placed on the patient's occipital scalp, i.e., at the "O1, Oz, O2" positions in the international standard lead 10-20 system.

[0053] Furthermore, the EEG signal collector 10 is further configured to instruct the patient to close their eyes and collect resting-state EEG signals with eyes closed for a first preset duration, and to instruct the patient to open their eyes and collect resting-state EEG signals with eyes open for a first preset duration. Optionally, the first preset duration is set to 5 minutes.

[0054] In one embodiment, Figure 2 As shown, the controller 20 includes a target frequency determination module 21, which is connected to the EEG signal collector 10 and the electrical stimulation signal generator 30 respectively, and is used to receive the eyes-closed resting-state EEG signal and the eyes-open resting-state EEG signal transmitted by the EEG signal collector 10; generate an alpha-band eyes-closed power spectrum based on the eyes-closed resting-state EEG signal, and generate an alpha-band eyes-open power spectrum based on the eyes-open resting-state EEG signal, and determine the target alpha frequency corresponding to the patient based on the alpha-band eyes-closed power spectrum and the alpha-band eyes-open power spectrum; and transmit the target alpha frequency corresponding to the patient to the electrical stimulation signal generator 30.

[0055] Specifically, the target frequency determination module 21 is also used to generate a first power spectrum based on the eyes-closed resting-state EEG signal, and to generate a second power spectrum based on the eyes-open resting-state EEG signal; extract the alpha band eyes-closed power spectrum from the first power spectrum, and extract the alpha band eyes-open power spectrum from the second power spectrum; and determine the target alpha frequency corresponding to the patient based on the alpha band eyes-closed power spectrum and the alpha band eyes-open power spectrum.

[0056] In one embodiment, Figure 3 and Figure 4As shown, the target frequency determination module 21 includes an EEG signal processing unit 211, a power spectrum generating unit 212 and a target frequency determination unit 213, wherein:

[0057] The EEG signal processing unit 211 is connected to the power spectrum generating unit 212, and is used to filter the eyes-closed resting-state EEG signals and the eyes-open resting-state EEG signals, and segment the filtered eyes-closed resting-state EEG signals and the eyes-open resting-state EEG signals to obtain multiple segments of eyes-closed EEG signals and multiple segments of eyes-open EEG signals.

[0058] In one embodiment, the EEG signal processing unit 211 is further configured to filter the eyes-closed resting-state EEG signal and the eyes-open resting-state EEG signal based on the high-pass filter signal and the low-pass filter signal, respectively. Furthermore, the cutoff frequency of the high-pass filter signal is 0.1 Hz, and the cutoff frequency of the low-pass filter signal is 30 Hz.

[0059] In one embodiment, the filtered eyes-closed resting-state EEG signal and eyes-open resting-state EEG signal are segmented based on a preset number of segments and a preset signal length to obtain multiple segments of eyes-closed EEG signals and multiple segments of eyes-open EEG signals. For example, the preset number of segments is 20 segments and the preset signal length is 12 seconds. From the filtered eyes-closed resting-state EEG signal and eyes-open resting-state EEG signal, 20 segments of 12-second eyes-closed EEG signals and 20 segments of 12-second eyes-open EEG signals are intercepted.

[0060] Furthermore, the EEG signal processing unit 211 is further configured to transmit multiple segments of eyes-closed EEG signals and multiple segments of eyes-open EEG signals to the power spectrum generating unit 212 .

[0061] The power spectrum generation unit 212 is connected to the target frequency determination unit 213, and is used to obtain a first power spectrum corresponding to multiple segments of closed-eye EEG signals and a second power spectrum corresponding to multiple segments of open-eye EEG signals, and extract the alpha band closed-eye power spectrum from the first power spectrum, and extract the alpha band open-eye power spectrum from the second power spectrum.

[0062] In one embodiment, discrete Fourier transform is performed on multiple segments of closed-eye EEG signals and multiple segments of open-eye EEG signals to obtain a first power spectrum and a second power spectrum. 0≤n≤N , its discrete Fourier transform can be expressed by the following formula (1):

[0063]

[0064] Wherein, k=0, 1, ..., N-1, N represents the number of points, and n represents any point in the sequence. Furthermore, the frequency resolution of the first power spectrum and the second power spectrum is 0.25 Hz.

[0065] In one embodiment, the power spectrum generation unit 212 is further used to extract the alpha band eyes-closed power spectrum from the first power spectrum of the full frequency band, and to extract the alpha band eyes-open power spectrum from the second power spectrum of the full frequency band, wherein the alpha band eyes-closed power spectrum represents the power spectrum corresponding to the eyes-closed EEG signal in the alpha band, and the alpha band eyes-open power spectrum represents the power spectrum corresponding to the eyes-open EEG signal in the alpha band.

[0066] Furthermore, the power spectrum generating unit 212 is further configured to transmit the alpha band eyes-closed power spectrum and the alpha band eyes-open power spectrum to the target frequency determining unit 213 .

[0067] The target frequency determination unit 213 is configured to obtain the power difference between the eyes-closed resting power and the eyes-open resting power corresponding to each alpha frequency point in the alpha frequency band based on the eyes-closed power spectrum and the eyes-open power spectrum, and determine the alpha frequency point with the highest power difference as the target alpha frequency.

[0068] The alpha frequency range is 7-14 Hz. The target alpha frequency can also be called Figure 4 as well as Figure 5 The individual alpha frequency in, that is, the alpha frequency corresponding to each individual.

[0069] Currently, the intensity of transorbital alternating current stimulation provided to glaucoma patients in clinical practice is set to take into account individual differences, that is, the stimulation intensity dose is determined based on the patient's verbal report. However, this subjective report is difficult to standardize. If the stimulation intensity reaches a level that can activate their damaged visual pathways, when the patient closes their eyes and receives transorbital alternating current stimulation, they will see flashes of light, called phosphenes, and the lowest current intensity that can induce clear phosphenes is called the phosphene threshold. The current intensity of the first transorbital alternating current stimulation intervention for patients is currently set to the phosphene threshold plus 0.1 mA. However, patients have difficulty distinguishing between dim light and clear phosphenes, especially those with severe visual impairment. This results in some patients having a weak response to the transorbital alternating current stimulation they receive, making it impossible to determine the stimulation intensity of transorbital alternating current stimulation intervention based on the patient's verbal report.

[0070] Based on this, at least one embodiment is provided below to solve the technical problem in the prior art that the stimulation intensity of the transorbital alternating current stimulation intervention cannot be accurately determined.

[0071] In one embodiment, Figure 2 As shown, the electrical stimulation signal generator 30 is further configured to output a first alternating current electrical stimulation signal through electrical stimulation electrodes placed at the patient's eye sockets, so as to apply electrical stimulation to the patient's eye sockets.

[0072] The EEG signal collector 10 is also used to collect the first electrical stimulation EEG signal of the patient's eye socket when it is electrically stimulated by the first alternating current stimulation signal through EEG recording electrodes placed on the patient's occipital scalp, and transmit the first electrical stimulation EEG signal to the controller 20.

[0073] The controller 20 is further configured to determine a target AC electrical stimulation intensity corresponding to the patient based on the first electrical stimulation EEG signal, and transmit the target AC electrical stimulation intensity to the electrical stimulation signal generator 30 .

[0074] Among them, the first AC stimulation signal is used to perform pre-intervention of trans-orbital AC stimulation on the patient, so as to determine the target AC stimulation intensity when the patient is formally intervened with trans-orbital AC stimulation based on the first electrical stimulation EEG signal of the patient's orbit when the pre-intervention electrical stimulation is applied by the first AC stimulation signal.

[0075] The electrical stimulation signal generator 30 is further configured to generate a second AC stimulation signal corresponding to the patient based on the target AC stimulation intensity and the target alpha frequency, and output the second AC stimulation signal to apply electrical stimulation to the patient's eye socket.

[0076] The second AC stimulation signal is determined based on the target AC stimulation intensity and target alpha frequency for each patient, and is used to perform a formal orbital AC stimulation intervention on the patient. Furthermore, the electrical stimulation signal generator 30 is further configured to output the second AC stimulation signal via an electrical stimulation electrode placed in the patient's orbit to apply electrical stimulation to the patient's orbit.

[0077] The above embodiment, by placing EEG recording electrodes on the patient's occipital scalp, collects the first electrical stimulation EEG signal of the patient's eye socket when it is electrically stimulated by the first alternating current stimulation signal, and analyzes the first electrical stimulation EEG signal to measure the steady-state visual evoked potential formed in the occipital lobe by the phosphene induced by the orbital alternating current stimulation, thereby obtaining an objective measurement of the intensity of individual phosphenes, that is, the target alternating current stimulation intensity corresponding to different patients, thereby improving the accuracy of the stimulation intensity dose setting of the orbital alternating current stimulation intervention, and solving the technical problem in the prior art that the stimulation intensity of the orbital alternating current stimulation intervention cannot be accurately determined.

[0078] In one embodiment, the electrical stimulation signal generator 30 is also used to generate a plurality of first alternating current stimulation signals of different current intensities based on a target alpha frequency and a preset current intensity gradient, and to apply electrical stimulation to the patient's eye socket based on the first alternating current stimulation signal of each current intensity through an electrical stimulation electrode placed at the patient's eye socket.

[0079] The electrical stimulation electrodes are placed at the patient's eye sockets. Furthermore, the electrical stimulation electrodes are placed at the upper part of the patient's eye sockets, namely the "F7, F8" positions in the international standard lead 10-20 system.

[0080] In one embodiment, the electrical stimulation signal generator 30 is further configured to output a plurality of first AC stimulation signals with different current intensities in an ascending order of current intensities. The preset current intensity gradient represents the current intensity increment of the first AC stimulation signal. For example, Figure 5 In the embodiment, the electrical stimulation signal generator 30 is used to sequentially output a first alternating current stimulation signal with a current intensity ranging from intensity 1 to intensity 10 to apply electrical stimulation to the patient's eye socket.

[0081] Furthermore, the electrical stimulation signal generator 30 is further configured to set an initial current intensity of 0.1 mA and output multiple first AC stimulation signals with increasing current intensities according to a 0.1 mA current intensity gradient. The electrical stimulation signal generator 30 also applies electrical stimulation to the patient's eye socket for a first stimulation duration using the first AC stimulation signal based on each current intensity. For example, the first stimulation duration is 1 minute.

[0082] In one embodiment, Figure 2 As shown, the EEG signal collector 10 is also used to collect the first electrical stimulation EEG signal of the patient's eye socket when it is subjected to the first alternating current stimulation signal of each current intensity through EEG recording electrodes placed on the patient's occipital scalp, and transmit the first electrical stimulation EEG signal corresponding to each current intensity to the controller 20.

[0083] For example, in Figure 5 In the embodiment, the EEG signal collector 10 is used to collect the first electrical stimulation EEG signal when the patient's eye socket is electrically stimulated by a first alternating current stimulation signal with a current intensity of intensity 1 to intensity 10, specifically including EEG signals corresponding to intensity 1 to EEG signals corresponding to intensity 10.

[0084] In one embodiment, Figure 2 As shown, the controller 20 also includes a stimulation intensity determination module 22; the stimulation intensity determination module 22 is connected to the EEG signal collector 10, and is used to receive a first electrical stimulation EEG signal corresponding to each current intensity; based on the first electrical stimulation EEG signal corresponding to each current intensity, the target second harmonic signal-to-noise ratio corresponding to the target alpha frequency at each current intensity is determined; based on the target second harmonic signal-to-noise ratio corresponding to each current intensity, a corresponding curve between the current intensity and the second harmonic signal-to-noise ratio is generated, and based on the corresponding curve, the target AC stimulation intensity corresponding to each preset signal-to-noise ratio is determined.

[0085] The preset signal-to-noise ratio is not less than a preset threshold value. For example, when the preset threshold value is 75%, the preset signal-to-noise ratio may be 75%, 80%, 85%, 90%, 95% and 100%.

[0086] In one embodiment, Figure 5 and Figure 6 As shown, the stimulation intensity determination module 22 includes an EEG signal filtering unit 221, an EEG signal segmentation unit 222, an EEG signal superposition unit 223, a target power determination unit 224, a target signal-to-noise ratio determination unit 225, and a stimulation intensity determination unit 226, wherein:

[0087] The EEG signal filtering unit 221 is connected to the EEG signal segmenting unit 222 and is used to filter the first electrical stimulation EEG signal corresponding to each current intensity to obtain the first electrical stimulation EEG signal corresponding to each current intensity after filtering.

[0088] In one embodiment, the EEG signal filtering unit 221 is also used to filter the first electrical stimulation EEG signal corresponding to each current intensity based on the high-pass filtering signal and the notch filtering signal. Furthermore, the cutoff frequency of the high-pass filtering signal is 1 Hz, and the stop band of the notch filtering signal is 48 to 52 Hz.

[0089] Furthermore, the EEG signal filtering unit 221 is further configured to transmit the first electrical stimulation EEG signal corresponding to each current intensity after filtering to the EEG signal segmentation unit 222 .

[0090] The EEG signal segmentation unit 222 is connected to the EEG signal superposition unit 223, and is used to segment the first electrical stimulation EEG signal corresponding to each current intensity after filtering processing based on the preset segmentation length and the preset overlap length to obtain multiple segments of electrical stimulation EEG signals.

[0091] Furthermore, the preset segment length is 1000 milliseconds and the preset overlap length is 100 milliseconds. That is, the EEG signal segmentation unit 222 is used to cut the first electrical stimulation EEG signal corresponding to each current intensity after filtering into multiple electrical stimulation EEG signals with a segment length of 1000 milliseconds and an overlap length of 100 milliseconds.

[0092] Furthermore, the EEG signal segmentation unit 222 is further configured to transmit multiple segments of electrical stimulation EEG signals corresponding to each current intensity to the EEG signal superposition unit 223 .

[0093] The EEG signal superposition unit 223 is connected to the target power determination unit 224 and is used to superimpose and average multiple segments of electrical stimulation EEG signals corresponding to each current intensity to obtain a second electrical stimulation EEG signal corresponding to each current intensity.

[0094] The superposition and averaging process refers to superimposing multiple segments of electro-stimulation EEG signals and taking an average value. Furthermore, the EEG signal superposition unit 223 is further configured to transmit the second electro-stimulation EEG signal corresponding to each current intensity to the target power determination unit 224 .

[0095] The target power determination unit 224 is connected to the target signal-to-noise ratio determination unit 225, and is used to obtain the third power spectrum of the second electrical stimulation EEG signal corresponding to each current intensity, and obtain the target second harmonic power value corresponding to the target alpha frequency at each current intensity based on the third power spectrum.

[0096] Specifically, the target power determination unit 224 is further configured to find out the target second harmonic power value corresponding to the target alpha frequency at each current intensity from the third power spectrum of the full frequency band corresponding to each current intensity.

[0097] Furthermore, the target power determination unit 224 is further configured to transmit the target second harmonic power value corresponding to the target alpha frequency at each current intensity to the target signal-to-noise ratio determination unit 225 .

[0098] The target signal-to-noise ratio determination unit 225 is connected to the stimulation intensity determination unit 226, and is used to obtain the target second harmonic signal-to-noise ratio corresponding to the target alpha frequency at each current intensity based on the target second harmonic power value corresponding to the target alpha frequency at each current intensity and the preset average noise power value.

[0099] The preset average noise power value represents the average power value of the surrounding noise frequency band (±0.5 Hz). Specifically, the target signal-to-noise ratio determination unit 225 is further configured to divide the target second harmonic power value corresponding to the target alpha frequency at each current intensity by the preset average noise power value to obtain the target second harmonic signal-to-noise ratio corresponding to the target alpha frequency at each current intensity.

[0100] Furthermore, the target signal-to-noise ratio determination unit 225 is further configured to transmit the target second harmonic signal-to-noise ratio corresponding to the target alpha frequency at each current intensity to the stimulation intensity determination unit 226 .

[0101] The stimulation intensity determination unit 226 is used to normalize and curve fit the target second harmonic signal-to-noise ratio corresponding to the target alpha frequency at each current intensity, generate a corresponding curve between current intensity and second harmonic signal-to-noise ratio, and determine the target AC stimulation intensity corresponding to each preset signal-to-noise ratio based on the corresponding curve.

[0102] Among them, the schematic diagram of the corresponding curve between current intensity and second harmonic signal-to-noise ratio is as follows Figure 5Shown are the fitting curves of stimulation intensity and second harmonic signal-to-noise ratio.

[0103] Furthermore, the stimulation intensity determination unit 226 is also used to obtain the target AC stimulation intensities corresponding to the preset signal-to-noise ratios of 75%, 80%, 85%, 90%, 95% and 100% from the corresponding curves, so as to use the target AC stimulation intensities corresponding to 75%, 80%, 85%, 90%, 95% and 100% as the AC stimulation intensities adopted for formal intervention.

[0104] In one embodiment, Figure 7 As shown, the controller 20 further includes a stimulation output control module 23, which includes a stimulation intensity division unit 231, a first output control unit 232 and a second output control unit 233, wherein:

[0105] The stimulation intensity division unit 231 is connected to the first output control unit 232 and the second output control unit 233, and is used to divide the target AC stimulation intensities corresponding to multiple preset signal-to-noise ratios into target AC stimulation intensities of the first level intensity and target AC stimulation intensities of the second level intensity.

[0106] Furthermore, the stimulation intensity division unit 231 is also used to transmit the target AC stimulation intensity of the first level intensity to the first output control unit 232, and transmit the target AC stimulation intensity of the second level intensity to the second output control unit 233.

[0107] The first output control unit 232 is connected to the electrical stimulation signal generator 30, and is used to control the electrical stimulation signal generator 30 during the first electrical stimulation cycle, and output a second AC stimulation signal based on the target alpha frequency and the target AC stimulation intensity of the first level intensity to apply electrical stimulation to the patient's eye socket.

[0108] There are multiple target AC stimulation intensities of the first level, and there is a certain intensity gradient between the target AC stimulation intensities of the first level. The electrical stimulation signal generator 30 also uses a second AC stimulation signal based on the target AC stimulation intensities of the first level to apply electrical stimulation to the patient's eye socket for a second stimulation duration. For example, the second stimulation duration is 1 hour.

[0109] In one embodiment, the first output control unit 232 is also used to control the electrical stimulation signal generator 30 during the first electrical stimulation cycle, and output a plurality of second AC stimulation signals of target AC stimulation intensities of the first level intensities in sequence in increasing order of stimulation intensity to apply electrical stimulation to the patient's eye sockets.

[0110] For example, the target AC stimulation intensities corresponding to the preset signal-to-noise ratios of 75%, 80%, 85%, 90% and 95% are determined as the target AC stimulation intensities of the first level intensity. The first electrical stimulation cycle is 5 days. The electrical stimulation signal generator 30 is used to output a second AC stimulation signal according to the target AC stimulation intensity with a preset signal-to-noise ratio of 75% on the first day of the first electrical stimulation cycle; output a second AC stimulation signal according to the target AC stimulation intensity with a preset signal-to-noise ratio of 80% on the second day of the first electrical stimulation cycle; output a second AC stimulation signal according to the target AC stimulation intensity with a preset signal-to-noise ratio of 85% on the third day of the first electrical stimulation cycle; output a second AC stimulation signal according to the target AC stimulation intensity with a preset signal-to-noise ratio of 90% on the fourth day of the first electrical stimulation cycle; output a second AC stimulation signal according to the target AC stimulation intensity with a preset signal-to-noise ratio of 95% on the fifth day of the first electrical stimulation cycle, and the second stimulation duration of each AC stimulation intervention is 1 hour.

[0111] The second output control unit 233 is connected to the electrical stimulation signal generator 30, and is used to control the electrical stimulation signal generator 30 during the second electrical stimulation cycle, and output a second AC stimulation signal based on the target alpha frequency and the target AC stimulation intensity of the second level intensity to apply electrical stimulation to the patient's eye socket.

[0112] The number of target AC stimulation intensities of the second level is one, and the target AC stimulation intensity of the second level is the highest AC stimulation intensity. The electrical stimulation signal generator 30 further applies electrical stimulation to the patient's eye socket for a second stimulation duration using a second AC stimulation signal based on the target AC stimulation intensity of the second level. For example, the second stimulation duration is one hour.

[0113] For example, the target AC electrical stimulation intensity corresponding to a preset signal-to-noise ratio of 100% is determined as the target AC electrical stimulation intensity of the second level. The second electrical stimulation cycle is 5 days. The electrical stimulation signal generator 30 is further configured to output a second AC electrical stimulation signal at the target AC electrical stimulation intensity with a preset signal-to-noise ratio of 100% on each day of the second electrical stimulation cycle, and the second stimulation duration of each AC electrical stimulation intervention is 1 hour.

[0114] The above embodiment analyzes the eyes-closed resting-state EEG signals and eyes-open resting-state EEG signals of different patients, thereby determining the target alpha frequency corresponding to each patient based on the analysis results, generating a first AC stimulation signal with gradually increasing intensity, and collecting the first electrical stimulation EEG signals of the patient's eye sockets when subjected to the first AC stimulation signal of each current intensity, and then generating a target AC stimulation signal adapted to the brain discharge rhythm and neural regulation rhythm of each patient based on the first electrical stimulation EEG signals, thereby improving the effect of the AC stimulation signal on the patient and enhancing the neural regulation effect on the patient's damaged visual pathway, thereby achieving better auxiliary treatment of the patient's vision impairment, and solving the technical problem of how to generate adapted AC stimulation signals for different patients.

[0115] The device embodiments described above are merely illustrative. The units described as separate components may or may not be physically separate, and the components shown as units may or may not be physical units. That is, they may be located in one place or distributed across multiple network units. Some or all of the modules may be selected based on actual needs to achieve the objectives of the present embodiment. Persons of ordinary skill in the art will be able to understand and implement the present invention without inventive effort.

[0116] Through the description of the above embodiments, those skilled in the art can clearly understand that each embodiment can be implemented by means of software plus the necessary general hardware platform, or of course, by hardware. Based on this understanding, the essence of the above technical solution or the part that contributes to the existing technology can be embodied in the form of a software product. The computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, a magnetic disk, an optical disk, etc., and includes a number of instructions for causing a computer device (which can be a personal computer, a server, or a network device, etc.) to execute the methods of each embodiment or certain parts of the embodiment.

[0117] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A transorbital electrical stimulation device, characterized in that include: EEG signal collector, controller and electrical stimulation signal generator, including: The EEG signal collector is connected to the controller and is used to collect the patient's eyes-closed resting state EEG signals and eyes-open resting state EEG signals, and transmit them to the controller; The controller is connected to the electrical stimulation signal generator, and is used to obtain the target alpha frequency corresponding to the patient based on the eyes-closed resting-state EEG signal and the eyes-open resting-state EEG signal, and transmit the target alpha frequency to the electrical stimulation signal generator; The electrical stimulation signal generator is configured to generate a first alternating current electrical stimulation signal based on a target alpha frequency corresponding to the patient, and output the first alternating current electrical stimulation signal to apply electrical stimulation to the patient's eye socket; The controller includes a target frequency determination module; The target frequency determination module is configured to generate an alpha band eyes-closed power spectrum based on the eyes-closed resting-state EEG signal, and generate an alpha band eyes-open power spectrum based on the eyes-open resting-state EEG signal, and determine a target alpha frequency corresponding to the patient based on the alpha band eyes-closed power spectrum and the alpha band eyes-open power spectrum; The target frequency determination module includes: an EEG signal processing unit, configured to filter the eyes-closed resting-state EEG signal and the eyes-open resting-state EEG signal, and segment the filtered eyes-closed resting-state EEG signal and the eyes-open resting-state EEG signal to obtain multiple segments of eyes-closed EEG signals and multiple segments of eyes-open EEG signals; a power spectrum generating unit, configured to obtain a first power spectrum corresponding to the plurality of segments of eyes-closed EEG signals and a second power spectrum corresponding to the plurality of segments of eyes-open EEG signals, and extract an alpha band eyes-closed power spectrum from the first power spectrum, and extract an alpha band eyes-open power spectrum from the second power spectrum; a target frequency determination unit, configured to obtain, based on the alpha band eyes-closed power spectrum and the alpha band eyes-open power spectrum, a power difference between the eyes-closed resting power and the eyes-open resting power corresponding to each alpha frequency point in the alpha band, and determine the alpha frequency point with the highest power difference as the target alpha frequency.

2. The transorbital electrical stimulation device according to claim 1, wherein The EEG signal collector is also used to collect the patient's eyes-closed resting state EEG signals and eyes-open resting state EEG signals through EEG recording electrodes placed on the patient's occipital scalp.

3. The transorbital electrical stimulation device according to claim 1, wherein The EEG signal collector is further configured to collect a first electrical stimulation EEG signal when the patient's eye socket is electrically stimulated by the first alternating current stimulation signal, and transmit the first electrical stimulation EEG signal to the controller; The controller is further configured to determine a target AC electrical stimulation intensity corresponding to the patient based on the first electrical stimulation EEG signal, and transmit the target AC electrical stimulation intensity to the electrical stimulation signal generator; The electrical stimulation signal generator is further configured to generate a second AC stimulation signal corresponding to the patient based on the target AC stimulation intensity and the target alpha frequency, and output the second AC stimulation signal to apply electrical stimulation to the patient's eye socket.

4. The transorbital electrical stimulation device according to claim 3, wherein: The electrical stimulation signal generator is also used to generate a plurality of first alternating current stimulation signals with different current intensities based on the target alpha frequency and a preset current intensity gradient, and to apply electrical stimulation to the patient's eye socket based on the first alternating current stimulation signal of each current intensity through an electrical stimulation electrode placed at the patient's eye socket.

5. The transorbital electrical stimulation device according to claim 4, wherein: The EEG signal collector is also used to collect the first electrical stimulation EEG signal of the patient's eye socket when it is subjected to the first alternating current stimulation signal of each current intensity through EEG recording electrodes placed on the patient's occipital scalp.

6. The transorbital electrical stimulation device according to claim 5, wherein: The controller further includes a stimulation intensity determination module; The stimulation intensity determination module is configured to determine a target second harmonic signal-to-noise ratio corresponding to the target alpha frequency at each current intensity based on the first electrical stimulation EEG signal corresponding to each current intensity; Based on the target second harmonic signal-to-noise ratio corresponding to each current intensity, a corresponding curve between the current intensity and the second harmonic signal-to-noise ratio is generated, and based on the corresponding curve, a target AC stimulation intensity corresponding to each preset signal-to-noise ratio is determined.

7. The transorbital electrical stimulation device according to claim 6, wherein: The stimulation intensity determination module includes: an electroencephalogram signal filtering unit, configured to filter the first electroencephalogram signal corresponding to each current intensity to obtain the first electroencephalogram signal corresponding to each current intensity after filtering; an EEG signal segmentation unit, configured to segment the first electrical stimulation EEG signal corresponding to each current intensity after filtering, based on a preset segment length and a preset overlap length, to obtain a plurality of segments of electrical stimulation EEG signals; an EEG signal superposition unit, configured to superimpose and average multiple segments of electrical stimulation EEG signals corresponding to each current intensity to obtain a second electrical stimulation EEG signal corresponding to each current intensity; a target power determination unit, configured to obtain a third power spectrum of the second electrical stimulation EEG signal corresponding to each current intensity, and obtain a target second harmonic power value corresponding to the target alpha frequency at each current intensity based on the third power spectrum; a target signal-to-noise ratio determining unit, configured to obtain a target second harmonic signal-to-noise ratio corresponding to the target alpha frequency at each current intensity based on a target second harmonic power value corresponding to the target alpha frequency at each current intensity and a preset average noise power value; a stimulation intensity determination unit, configured to perform normalization and curve fitting on the target second harmonic signal-to-noise ratio corresponding to the target alpha frequency at each current intensity, generate a corresponding curve between the current intensity and the second harmonic signal-to-noise ratio, and determine the target alternating current stimulation intensity corresponding to each preset signal-to-noise ratio based on the corresponding curve.

8. The transorbital electrical stimulation device according to claim 6, wherein: The controller further includes a stimulation output control module, which includes: a stimulation intensity division unit, configured to divide the target AC stimulation intensities corresponding to the plurality of preset signal-to-noise ratios into target AC stimulation intensities of a first level of intensity and target AC stimulation intensities of a second level of intensity; a first output control unit, configured to control the electrical stimulation signal generator during a first electrical stimulation cycle to output the second alternating current electrical stimulation signal based on the target alpha frequency and the target alternating current stimulation intensity of the first level of intensity, so as to apply electrical stimulation to the patient's eye socket; The second output control unit is used to control the electrical stimulation signal generator during a second electrical stimulation cycle, and output the second AC electrical stimulation signal based on the target alpha frequency and the target AC electrical stimulation intensity of the second level intensity to apply electrical stimulation to the patient's eye socket.

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