A Medicinal Packaging Aluminum Foil Easy-to-Peel Cold-Sealing Adhesive Layer Material and Its Preparation Method

Abstract

This application relates to the technical field of pharmaceutical packaging, and specifically discloses a material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil and a preparation method thereof. A material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil is made from raw materials comprising the following parts by weight: 50-70 parts of isooctyl acrylate, 35-45 parts of vinyl acetate, 2.5-4 parts of acrylic acid, 3-5 parts of β-carboxyethyl acrylate, 10-15 parts of vinyl silicone oil, and 1-1.8 parts of an initiator. A preparation method of a material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil comprises the following steps: mixing isooctyl acrylate, vinyl acetate, acrylic acid, β-carboxyethyl acrylate, vinyl silicone oil and a solvent, heating, adding an initiator, and carrying out a heat preservation reaction. The material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil of this application has the advantages of being easily peelable and not generating residual glue.

Description

Technical Field

[0001] The present application relates to the technical field of pharmaceutical packaging, and more specifically, to an easily peelable cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil and a preparation method thereof. Background Art

[0002] At present, the packaging production lines of pharmaceutical enterprises are becoming more and more high-speed. Conventional hot-melt adhesives need to be heated and melted, evenly spread, and instantaneously sealed within a certain time, facing great challenges. On this basis, cold-sealing adhesive layer materials (cold-sealing adhesives) have emerged. When using cold-sealing adhesives for packaging, heating is not required, and only the sealing pressure needs to be controlled. The production speed of cold-sealing packaging is higher than that of hot-sealing packaging, and it will not cause shrinkage of materials due to heat, and a flat sealing shape can be obtained, having advantages unparalleled by hot-sealing packaging.

[0003] The cold-sealing adhesive for pharmaceutical packaging aluminum foil needs to have properties such as low peel strength and no residual glue left when peeled from the surface of the adherend. However, after the cold-sealing adhesive is used, it is generally peeled off after a period of time. During this period, the peel strength of the cold-sealing adhesive is unstable and often gradually increases over time. When the peel strength of the cold-sealing adhesive is too high, it will cause difficult peeling and even residual glue phenomenon, affecting the use performance of the cold-sealing adhesive. Summary of the Invention

[0004] In order to solve the problem of easy generation of residual glue phenomenon after peeling of the cold-sealing adhesive, the present application provides an easily peelable cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil and a preparation method thereof.

[0005] In the first aspect, the present application provides an easily peelable cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil, adopting the following technical solution:

[0006] An easily peelable cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil is made from raw materials comprising the following parts by weight: 50 - 70 parts of isooctyl acrylate, 35 - 45 parts of vinyl acetate, 2.5 - 4 parts of acrylic acid, 3 - 5 parts of β-carboxyethyl acrylate, 10 - 15 parts of vinyl silicone oil, and 1 - 1.8 parts of initiator.

[0007] By adopting the above technical solution, isooctyl acrylate is used as a soft monomer with a relatively low glass transition temperature, which endows the cold-sealing adhesive with sufficient fluidity to quickly fill uneven bonding surfaces and gives the cold-sealing adhesive good initial adhesion; vinyl acetate is used as a hard monomer, which can improve the cohesive force and holding power of the cold-sealing adhesive; vinyl silicone oil has a smooth and anti-agglomeration property, which can reduce the peel strength of the cold-sealing adhesive and achieve the effect of easy peeling and avoiding residue; acrylic acid and β-carboxyethyl acrylate contain active groups, which crosslink with the active groups on other monomers through hydrogen bonds, improving the crosslinking degree of the cold-sealing adhesive. On the one hand, it reduces the possibility of small molecules migrating to the surface of the adhesive layer and causing residual glue; on the other hand, it reduces the fluidity of the cold-sealing adhesive. Within this weight range with isooctyl acrylate, they work together to make the fluidity of the cold-sealing adhesive moderate, while ensuring good initial adhesion, improving the stability of the peel strength of the cold-sealing adhesive, and avoiding a large increase in the peel strength over time, resulting in too high peel strength, difficult peeling, and residual glue, thus solving the problem of easy generation of residual glue after peeling of the cold-sealing adhesive.

[0008] Preferably, the mass ratio of the isooctyl acrylate to the vinyl acetate is (1.5 - 1.8):1.

[0009] By adopting the above technical solution, when the mass ratio of the isooctyl acrylate to the vinyl acetate is within this range, the mass ratio of the soft monomer to the hard monomer of the cold-sealing adhesive is moderate, and the prepared cold-sealing adhesive has both good initial adhesion and holding power.

[0010] Preferably, the easy-peeling cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil further includes 3 - 8 parts by weight of perfluorodecyl acrylate.

[0011] By adopting the above technical solution, the fluorinated side chain on the perfluorodecyl acrylate will migrate to the surface of the adhesive film, reducing its surface energy, inhibiting the increase of the peel strength, improving the stability of the peel strength, and further reducing the possibility of generating residual glue when peeling the cold-sealing adhesive.

[0012] Preferably, the easy-peeling cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil further includes 1.5 - 3 parts by weight of erucamide.

[0013] By adopting the above technical solution, erucamide also has good smooth and anti-agglomeration properties. Synergistic with vinyl silicone oil, it further inhibits the increase of the peel strength, improves the stability of the peel strength, and further reduces the possibility of generating residual glue when peeling the cold-sealing adhesive.

[0014] Preferably, the easy-peeling cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil further includes 2 - 4 parts by weight of nano-fillers.

[0015] By adopting the above technical solution, the nano-fillers can reduce the contact area between the cold sealant and the aluminum foil surface, avoiding the phenomenon that the contact area between the two gradually increases over time, resulting in a significant increase in the peel strength and residual glue during peeling; they can also interact with other components in the cold sealant to toughen and strengthen the pressure-sensitive adhesive and improve its peelability.

[0016] Preferably, the nano-fillers are montmorillonite and / or nano-calcium carbonate.

[0017] Preferably, the nano-fillers are nano-calcium carbonate.

[0018] By adopting the above technical solution, nano-calcium carbonate can also reduce the migration of small molecules to the surface of the adhesive layer, further reducing the possibility of residual glue.

[0019] Preferably, the easy-peel cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil further includes 2-5 parts by weight of glycidyl methacrylate.

[0020] By adopting the above technical solution, glycidyl methacrylate can crosslink with other components in the cold sealant to increase the degree of crosslinking, reduce the residual of small molecule migration, reduce the deformation force and fluidity of the pressure-sensitive adhesive, inhibit the increase of the peel strength, improve the stability of the peel strength, improve its peelability, and reduce the possibility of residual glue.

[0021] In the second aspect, the present application provides a preparation method for an easy-peel cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil, adopting the following technical solution:

[0022] A preparation method for an easy-peel cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil includes the following steps:

[0023] Mix isooctyl acrylate, vinyl acetate, acrylic acid, β-carboxyethyl acrylate, vinyl silicone oil and a solvent, heat up, add an initiator, and carry out a heat preservation reaction to obtain the easy-peel cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil.

[0024] In summary, the present application has the following beneficial effects:

[0025] 1. The present application uses acrylic acid and β-carboxyethyl acrylate as crosslinking aids to improve the crosslinking degree of the cold sealant. On the one hand, it reduces the possibility of small molecules migrating to the surface of the adhesive layer and causing residual glue. On the other hand, it reduces the fluidity of the cold sealant. Acting together with isooctyl acrylate within this weight range, the fluidity of the cold sealant is moderate, ensuring good initial adhesion while improving the stability of the peel strength of the cold sealant, avoiding a large increase over time, resulting in difficult peeling and residual glue.

[0026] 2. This application uses vinyl silicone oil and erucamide, both of which have good lubricity and anti-agglomeration properties. Their combined action further inhibits the increase in peel strength, improves the stability of peel strength, and further reduces the possibility of residual glue generation when peeling the cold sealant.

[0027] 3. This application adds nano-fillers such as montmorillonite to the cold sealant. The nano-fillers can reduce the contact area between the cold sealant and the aluminum foil surface, avoiding the phenomenon that the contact area between the two gradually increases over time, resulting in a large increase in peel strength and residual glue generation during peeling. They can also interact with other components in the cold sealant to toughen and strengthen the pressure-sensitive adhesive and improve its peelable performance. Detailed implementation mode

[0028] The following further elaborates on this application with reference to examples.

[0029] Unless otherwise specified, the specifications of the raw materials used in the following examples and comparative examples are shown in Table 1.

[0030] Table 1. Information on raw material specifications

[0031]

[0032] Examples

[0033] Example 1

[0034] A kind of easily peelable cold seal adhesive layer material for pharmaceutical packaging aluminum foil, and its formula is as follows:

[0035] 500 g of isooctyl acrylate, 350 g of vinyl acetate, 25 g of acrylic acid, 30 g of β-carboxyethyl acrylate, 100 g of vinyl silicone oil, 10 g of initiator azobisisobutyronitrile, and 1500 g of solvent ethyl acetate.

[0036] A kind of easily peelable cold seal adhesive layer material for pharmaceutical packaging aluminum foil is prepared according to the following steps:

[0037] Mix and stir isooctyl acrylate, vinyl acetate, acrylic acid, β-carboxyethyl acrylate, vinyl silicone oil and solvent ethyl acetate, heat up to 80 °C, add initiator azobisisobutyronitrile, keep the temperature for reaction for 2 h, and cool down to 25 °C to obtain the easily peelable cold seal adhesive layer material for pharmaceutical packaging aluminum foil.

[0038] Examples 2 - 5

[0039] A kind of easily peelable cold seal adhesive layer material for pharmaceutical packaging aluminum foil, which is different from Example 1 in that the raw material composition of the adhesive layer material is different, and the specific composition is shown in Table 2 below:

[0040] Table 2. Raw material composition of easily peelable cold seal adhesive layer material for pharmaceutical packaging aluminum foil

[0041]

[0042] Example 6

[0043] A cold-seal adhesive layer material for easily peelable pharmaceutical packaging aluminum foil, the difference from Example 1 is that: 30 g of perfluorodecyl acrylate is newly added to the raw materials of the adhesive layer material.

[0044] Example 7

[0045] A cold-seal adhesive layer material for easily peelable pharmaceutical packaging aluminum foil, the difference from Example 1 is that: 80 g of perfluorodecyl acrylate is newly added to the raw materials of the adhesive layer material.

[0046] Example 8

[0047] A cold-seal adhesive layer material for easily peelable pharmaceutical packaging aluminum foil, the difference from Example 1 is that: 15 g of erucamide is newly added to the raw materials of the adhesive layer material.

[0048] Example 9

[0049] A cold-seal adhesive layer material for easily peelable pharmaceutical packaging aluminum foil, the difference from Example 1 is that: 30 g of erucamide is newly added to the raw materials of the adhesive layer material.

[0050] Example 10

[0051] A cold-seal adhesive layer material for easily peelable pharmaceutical packaging aluminum foil, the difference from Example 1 is that: 20 g of montmorillonite is newly added to the raw materials of the adhesive layer material.

[0052] Example 11

[0053] A cold-seal adhesive layer material for easily peelable pharmaceutical packaging aluminum foil, the difference from Example 1 is that: 40 g of montmorillonite is newly added to the raw materials of the adhesive layer material.

[0054] Example 12

[0055] A cold-seal adhesive layer material for easily peelable pharmaceutical packaging aluminum foil, the difference from Example 1 is that: 40 g of nano calcium carbonate is newly added to the raw materials of the adhesive layer material.

[0056] Example 13

[0057] A cold-seal adhesive layer material for easily peelable pharmaceutical packaging aluminum foil, the difference from Example 1 is that: 20 g of glycidyl methacrylate is newly added to the raw materials of the adhesive layer material.

[0058] Example 14

[0059] A kind of easy-peeling cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil, the difference from Example 1 is that: 50 g of glycidyl methacrylate is newly added to the raw materials of the adhesive layer material.

[0060] Comparative example

[0061] Comparative examples 1-3

[0062] A kind of easy-peeling cold-sealing adhesive layer material for pharmaceutical packaging aluminum foil, the difference from Example 1 is that: the raw material composition of the adhesive layer material is different, and the specific composition is shown in Table 3 below:

[0063] Table 3. Raw material composition of the adhesive layer material

[0064]

[0065] Detection method

[0066] Referring to the method of GB / T4852-2002, the initial adhesion of the cold-sealing adhesive layer materials prepared in Examples 1-14 and Comparative Examples 1-3 was tested. The inclined plane rolling ball method was used for determination (the measurement angle was 30°), and the specific test results are shown in Table 4 below;

[0067] Referring to the method of GB / T2792-1995, the 180° peel strength test of the cold-sealing adhesive layer materials prepared in Examples 1-14 and Comparative Examples 1-3 was carried out (the adherend was pharmaceutical packaging aluminum foil, and the peel rate was 300 mm / min), and the specific test results are shown in Table 4 below;

[0068] The cold-sealing adhesive layer materials prepared in Examples 1-14 and Comparative Examples 1-3 were evenly coated on the pharmaceutical packaging aluminum foil and stored in an environment of 25°C for 30 days. Referring to the method of GB / T2792-1995, the 180° peel strength test of the cold-sealing adhesive layer materials prepared in Examples 1-14 and Comparative Examples 1-2 after being placed for 48 h was carried out (the adherend was pharmaceutical packaging aluminum foil, and the peel rate was 300 mm / min), and the specific test results are shown in Table 4 below;

[0069] Referring to the method of GB / 4851-1998, the tack-holding property of the cold-sealing adhesive layer materials prepared in Examples 1-14 and Comparative Examples 1-3 was tested, and the specific test results are shown in Table 4 below;

[0070] The cold-sealing adhesive layer materials prepared in Examples 1-14 and Comparative Examples 1-3 were evenly coated on the pharmaceutical packaging aluminum foil and stored in an environment of 85°C and a relative humidity of 85% for 48 h, and then peeled off to observe the residual glue situation. The specific test results are shown in Table 4 below;

[0071] Table 4. Performance detection of easy-peeling cold-sealing adhesive layer materials for pharmaceutical packaging aluminum foil

[0072]

[0073]

[0074] As can be seen from Table 4, the easy-peeling cold-sealing adhesive layer material of the pharmaceutical packaging aluminum foil prepared in the embodiments of the present application has excellent properties such as low peel strength, stable peel strength, good initial adhesion and holding adhesion performance, and no residual glue phenomenon on the surface of the pharmaceutical packaging aluminum foil.

[0075] Combining Example 1 and Comparative Example 1 and referring to Table 4, it can be seen that the 180° peel strength of Example 1 is 3.25 N / 25 mm, which is much lower than that of Comparative Example 1, which is 12.45 N / 25 mm. The growth rate of the 180° peel strength after 30 days is 8.31%, which is also much lower than that of Comparative Example 1, which is 50.44%. Residual glue phenomenon occurs during peeling in Comparative Example 1. This may be because: vinyl silicone oil is added in Example 1. Vinyl silicone oil has smoothness and anti-agglomeration properties, which can reduce the peel strength of the cold-sealing adhesive and achieve the effect of easy peeling and avoiding residue.

[0076] Combining Example 1 and Comparative Example 2 and referring to Table 4, it can be seen that the 180° peel strength of Example 1 is 3.25 N / 25 mm, which is much lower than that of Comparative Example 2, which is 13.72 N / 25 mm. The growth rate of the 180° peel strength after 30 days is 8.31%, which is also much lower than that of Comparative Example 2, which is 48.25%. Residual glue phenomenon occurs during peeling in Comparative Example 2. This may be because: acrylic acid and β-carboxyethyl acrylate are added in Example 1. Acrylic acid and β-carboxyethyl acrylate contain active groups, which crosslink with the active groups on other monomers through hydrogen bonds, increasing the crosslinking degree of the cold-sealing adhesive. On the one hand, it reduces the possibility of small molecules migrating to the surface of the glue layer and causing residual glue; on the other hand, it reduces the fluidity of the cold-sealing adhesive. Within this weight range with isooctyl acrylate, they work together to make the fluidity of the cold-sealing adhesive moderate, while ensuring good initial adhesion, improving the stability of the peel strength of the cold-sealing adhesive and avoiding a large increase over time, resulting in difficult peeling and residual glue.

[0077] Combining Example 1 and Comparative Example 3 and referring to Table 4, it can be seen that the initial adhesion of Example 1 is much greater than that of Comparative Example 3. This may be because: the content of acrylic acid and β-carboxyethyl acrylate in Comparative Example 3 is too high, resulting in excessive crosslinking, a significant decrease in the fluidity and flexibility of the cold-sealing adhesive, and a significant decrease in the initial adhesion, failing to meet the use performance of the cold-sealing adhesive.

[0078] This specific embodiment is only an explanation of the present application and does not limit the present application. After reading this specification, those skilled in the art can make modifications to this embodiment without creative contributions as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil, which is characterized in that: It is made of raw materials containing the following parts by weight: 50 - 70 parts of isooctyl acrylate, 35 - 45 parts of vinyl acetate, 2.5 - 4 parts of acrylic acid, 3 - 5 parts of β-carboxyethyl acrylate, 10 - 15 parts of vinyl silicone oil, 1 - 1.8 parts of initiator, and 1.5 - 3 parts by weight of erucamide.

2. The material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil according to claim 1, which is characterized in that: The mass ratio of the isooctyl acrylate to the vinyl acetate is (1.5 - 1.8) :

1.

3. The material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil according to claim 1, which is characterized in that: The material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil further includes 3 - 8 parts by weight of perfluorodecyl acrylate.

4. The material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil according to claim 1, which is characterized in that: The material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil further includes 2 - 4 parts by weight of nano filler.

5. The material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil according to claim 4, which is characterized in that: The nano filler is montmorillonite and / or nano calcium carbonate.

6. The material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil according to claim 5, which is characterized in that: The nano filler is nano calcium carbonate.

7. The material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil according to claim 1, which is characterized in that: The material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil further includes 2 - 5 parts by weight of glycidyl methacrylate.

8. The preparation method of the material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil according to claim 1, which is characterized in that: It includes the following steps: Mix and heat up erucamide, isooctyl acrylate, vinyl acetate, acrylic acid, β-carboxyethyl acrylate, vinyl silicone oil and a solvent, add an initiator, and carry out a heat preservation reaction to obtain the material for an easily peelable cold-sealing adhesive layer of pharmaceutical packaging aluminum foil.

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