An electrochemical synthesis of 3-iodo-4-amino-maleimide

The synthesis of 3-iodo-4-aminomaleimide by electrochemical method at room temperature and pressure solves the problems of metal catalysts and high temperature in existing methods, realizes a simple and efficient synthesis, and opens up a new synthetic route.

CN116121781BActive Publication Date: 2026-05-29ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Filing Date
2022-11-29
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing methods for synthesizing 3-iodo-4-aminomaleimide require metal catalysts and high temperatures, are cumbersome and time-consuming, and no electrochemical synthesis methods have been reported.

Method used

3-Iodo-4-aminomaleimide was synthesized by an electrochemical method at room temperature and pressure. N-phenylmaleimide, aromatic amine compounds or aliphatic amine compounds and iodides were used in the electrolytic reaction in an electrolytic cell. The iodides lost electrons at the anode and were oxidized to elemental iodine, which then reacted with the maleimide, avoiding the need for additional oxidants and metal catalysts.

Benefits of technology

It simplifies the synthesis process, reduces material consumption, saves energy, lowers equipment investment, provides a new synthetic route, and offers new ideas for the molecular design and synthesis of disubstituted maleimide derivatives.

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Abstract

The present application relates to the technical field of organic synthesis, and particularly relates to an electrochemical synthesis method of 3-iodo-4-amino maleimide, which comprises the following steps: adding N-phenyl maleimide, aromatic amine compound or aliphatic amine compound, iodide and other substances as reaction raw materials into an anode chamber of an electrolytic cell, adding a supporting electrolyte and ultrapure water into a cathode chamber, and electrolyzing at room temperature to synthesize 3-iodo-4-amino maleimide. The present application uses electrochemical reaction, realizes the preparation of products through the gain and loss of electrons of reactants on electrodes, does not need to add additional oxidants and metal catalysts, and the reaction is carried out at normal temperature and pressure, which is conducive to energy saving. The process flow is simple, the operation is simple, and the reaction is easy to control. The present application opens up a new synthesis route and method for the preparation of 3-iodo-4-amino maleimide compound, and has good application potential and research value.
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