An oral care product comprising hyaluronic acid and coconut oil and uses thereof

Abstract

The application provides an oral care composition containing hyaluronic acid and coconut oil and application thereof, and the composition comprises: hyaluronic acid; coconut oil; an orally acceptable carrier; wherein the hyaluronic acid comprises high-molecular-weight hyaluronic acid, medium-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid; the weight-average molecular weight of the high-molecular-weight hyaluronic acid is greater than or equal to 1000 KDa, the weight-average molecular weight of the medium-molecular-weight hyaluronic acid is 200-600 KDa, and the weight-average molecular weight of the low-molecular-weight hyaluronic acid is less than or equal to 10 KDa. The oral care composition can improve the stability problem of hyaluronic acid in a high-temperature preparation process.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of oral care, in particular to an oral care product containing hyaluronic acid and coconut oil and application thereof. BACKGROUND

[0002] Hyaluronic acid is an acidic mucopolysaccharide. In 1934, Professor Meyer of the Department of Ophthalmology of Columbia University in the United States first isolated this substance from the vitreous body of a cow's eye. Hyaluronic acid shows a variety of important physiological functions in the body due to its unique molecular structure and physicochemical properties, such as lubricating joints, regulating the permeability of blood vessel walls, regulating protein, water and electrolyte diffusion and transport, promoting wound healing, etc. In particular, hyaluronic acid has a special water retention effect and is the best moisturizing substance in nature so far, and is known as an ideal natural moisturizing factor (NMF). For example, a 2% pure hyaluronic acid aqueous solution can firmly retain 98% water. Hyaluronic acid is a multifunctional matrix and is widely distributed in various parts of the human body. A large amount of hyaluronic acid is also contained in the skin. The maturation and aging process of human skin also changes with the content and metabolism of hyaluronic acid. It can improve skin nutrition metabolism, make the skin tender, smooth, wrinkle-free, increase elasticity, prevent aging, and is a good transdermal absorption promoter while moisturizing. When used in combination with other nutritional ingredients, it can achieve a more ideal effect of promoting nutrient absorption. Therefore, hyaluronic acid has been widely used in oral care products.

[0003] For example, Chinese application CN105267234A discloses a composition for relieving dry mouth symptoms, which contains one or more of hyaluronic acid, pullulan, and polyglutamic acid. In this document, one or more ingredients containing hyaluronic acid, pullulan, and polyglutamic acid are prepared into product forms such as toothpaste, mouthwash, mouth freshening tablets, and chewing gum, providing a composition that can effectively lubricate the oral cavity and keep the oral cavity moist to relieve dry mouth symptoms.

[0004] For example, Chinese application CN110585062A discloses an oral care composition, which contains 30%-40% of hydrolyzed hyaluronic acid or its salt with a molecular weight of 2-5 kDa, 35%-45% of hyaluronic acid or its salt with a molecular weight of 200-600 kDa, and 20%-30% of hyaluronic acid or its salt with a molecular weight of 1300-1500 kDa. In this application document, the synergistic effect of the three different molecular weight segments of 2-5 kDa, 200-600 kDa, and 1300-1500 kDa or their salts can be used for both oral moisturizing and anti-inflammatory and repair for oral problems such as inflammation and ulcers, with multiple functions and meeting different needs.

[0005] Although hyaluronic acid has a relatively wide use in oral care products, there is a problem that hyaluronic acid is unstable and easy to decompose at a high temperature. However, the oral care composition often needs to go through a high temperature during the preparation process. For example, when preparing toothpaste, the preparation of glue needs to be completed at 70°C. The prepared glue is then mixed with hyaluronic acid and stirred at the temperature for 1.5-2 hours, at which time the stability of hyaluronic acid is affected. Therefore, it is necessary to find a suitable specification of hyaluronic acid and a method for improving its stability. SUMMARY

[0006] The first technical problem to be solved by the present application is to provide an oral care composition containing hyaluronic acid and coconut oil. The oral care composition can improve the stability of hyaluronic acid during the preparation process at a high temperature.

[0007] The second technical problem to be solved by the present application is the application of coconut oil in improving the stability of hyaluronic acid during the preparation process of oral care composition at a high temperature.

[0008] The third technical problem to be solved by the present application is to provide the application of the oral care composition containing hyaluronic acid and coconut oil in improving dry mouth.

[0009] The fourth technical problem to be solved by the present application is to provide the application of the oral care composition containing hyaluronic acid and coconut oil in reducing the astringent taste of zinc ions.

[0010] To solve the above-mentioned first technical problem, the present application adopts the following technical solution:

[0011] An oral care composition containing hyaluronic acid and coconut oil, comprising:

[0012] 1) hyaluronic acid;

[0013] 2) coconut oil;

[0014] 3) an orally acceptable carrier;

[0015] Among them, the hyaluronic acid comprises high molecular weight hyaluronic acid, medium molecular weight hyaluronic acid and low molecular weight hyaluronic acid;

[0016] The weight average molecular weight of the high molecular weight hyaluronic acid is ≥1000 KDa, the weight average molecular weight of the medium molecular weight hyaluronic acid is 200-600 Kda, and the weight average molecular weight of the low molecular weight hyaluronic acid is ≤10 KDa.

[0017] In some embodiments, the mass fraction of the high molecular weight hyaluronic acid in the hyaluronic acid is 20-30%, the mass fraction of the medium molecular weight hyaluronic acid in the hyaluronic acid is 30-50%, and the mass fraction of the low molecular weight hyaluronic acid in the hyaluronic acid is 30-40%.

[0018] In some embodiments, the hyaluronic acid is present in the oral care composition in an amount of 0.001-3% by weight.

[0019] In some preferred embodiments, the hyaluronic acid is present in the oral care composition in an amount of 0.01-3% by weight.

[0020] In some embodiments, the coconut oil is present in the oral care composition in an amount of 0.001-5% by weight.

[0021] In some preferred embodiments, the coconut oil is present in the oral care composition in an amount of 0.01-5% by weight.

[0022] In some embodiments, the oral care composition comprises hyaluronic acid and coconut oil in a weight ratio of 100:1-1:100.

[0023] In some embodiments, the oral care composition further comprises a soluble zinc salt.

[0024] In some preferred embodiments, the soluble zinc salt is derived from one or more of zinc citrate, zinc sulfate, zinc nitrate, zinc chloride, zinc gluconate.

[0025] In the most preferred embodiments, the soluble zinc salt is zinc citrate.

[0026] In some embodiments, the oral care composition comprises a mouthwash or a liquid toothpaste.

[0027] To solve the above-mentioned second technical problem, the present application provides the use of coconut oil in improving the stability of hyaluronic acid in the preparation of oral care compositions at high temperatures.

[0028] To solve the above-mentioned third technical problem, the present application provides the use of the above-mentioned oral care composition comprising hyaluronic acid and coconut oil in improving oral dryness.

[0029] To solve the above-mentioned fourth technical problem, the present application provides the use of the above-mentioned oral care composition comprising hyaluronic acid and coconut oil in reducing the astringent taste of zinc ions.

[0030] Unless otherwise specified, each raw material in the present application can be obtained by commercial purchase, and the equipment used in the present application can adopt conventional equipment in the field or refer to the existing technology in the field.

[0031] Advantages of the invention

[0032] Compared with the prior art, the present application provides an oral care composition containing high, medium and low molecular weight hyaluronic acid and coconut oil, which can improve the problem of instability of hyaluronic acid in the preparation process of the composition; in addition, the composition can also improve the problem of dry mouth and reduce the astringent taste of zinc ions. DETAILED DESCRIPTION

[0033] In order to more clearly illustrate the present application, the present application will be further described below in conjunction with preferred embodiments. It should be understood by those skilled in the art that the specific description below is illustrative rather than limiting, and should not limit the scope of protection of the present application.

[0034] Unless otherwise specified, all percentages and ratios used herein are based on weight of the total composition. Unless otherwise specified, all percentages, ratios, and levels of ingredients referred to herein are based on the actual amount of the ingredient, and do not include solvents, fillers, or other materials with which the ingredient can be combined as a commercially available product, unless otherwise indicated.

[0035] The term "comprising" or "including" or "containing" as used herein means that other steps and ingredients can be added which do not affect the end result.

[0036] The term "preferably" and its variants as used herein mean that the particular embodiment of the application is advantageous, but not a requirement. Other embodiments can be preferred in other settings. Furthermore, the description of one or more preferred embodiments does not indicate that no other embodiments are useful, and does not intend to exclude other embodiments from the scope of the application.

[0037] Unless otherwise specified, the specific conditions in the embodiments of the present application are carried out according to the conventional conditions or the conditions recommended by the manufacturer; the reagents or instruments used are not specified by the manufacturer, and are all conventional products that can be purchased on the market.

[0038] As an aspect of the present application, the present application provides an oral care composition comprising hyaluronic acid and coconut oil, which comprises:

[0039] 1) hyaluronic acid;

[0040] 2) coconut oil;

[0041] 3) an orally acceptable carrier;

[0042] The hyaluronic acid comprises high molecular weight hyaluronic acid, medium molecular weight hyaluronic acid and low molecular weight hyaluronic acid.

[0043] The weight average molecular weight of the high molecular weight hyaluronic acid is ≥1000 KDa, the weight average molecular weight of the medium molecular weight hyaluronic acid is 200-600 KDa, and the weight average molecular weight of the low molecular weight hyaluronic acid is ≤10 KDa.

[0044] Hyaluronic acid

[0045] Hyaluronic acid, also known as glucuronic acid or hyaluronan, is widely distributed in various parts of the human body; it is a high-molecular-weight polymer polysaccharide composed of unit D-glucuronic acid and N-acetylglucosamine, the D-glucuronic acid and N-acetylglucosamine are connected by β-1, 3-glycosidic bond, the disaccharide units are connected by β-1, 4-glycosidic bond, and the disaccharide units can reach 25,000. Its molecular formula is (C 14 H 21 NO 11 ) n, and has the following structural formula:

[0046]

[0047] It is unexpectedly found in the present application that when the oral care composition comprises hyaluronic acid and coconut oil, and the hyaluronic acid comprises high, medium and low molecular weight, wherein the weight average molecular weight of the high molecular weight hyaluronic acid is ≥1000kDa, the weight average molecular weight of the medium molecular weight hyaluronic acid is 200-600kDa, and the weight average molecular weight of the low molecular weight hyaluronic acid is ≤10kDa, the coconut oil can improve the stability problem of the hyaluronic acid in the composition prepared under high temperature conditions. In the present application, the hyaluronic acid also includes hyaluronic acid salts, such as sodium hyaluronate and potassium hyaluronate.

[0048] In certain embodiments of the application, the high molecular weight hyaluronic acid has a weight average molecular weight of > 1000 kDa, for example 1000-2000 kDa, 1000-1800 kDa, 1000-1700 kDa, 1000-1500 kDa, 1000-1300 kDa, 1000-1200 kDa, 1000-1100 kDa, 1100-2000 kDa, 1100-1800 kDa, 1100-1700 kDa, 1100-1500 kDa, 1100-1300 kDa, 1100-1200 kDa, 1200-2000 kDa, 1200-1800 kDa, 1200-1700 kDa, 1200-1500 kDa, 1200-1300 kDa, 1300-2000 kDa, 1300-1800 kDa, 1300-1700 kDa, 1300-1500 kDa, 1400-2000 kDa, 1400-1800 kDa, 1400-1700 kDa, 1400-1500 kDa, 1500-2000 kDa, 1500-1800 kDa, 1500-1700 kDa, 1600-2000 kDa, 1600-1800 kDa, 1600-1700 kDa, 1700-2000 kDa, 1700-1800 kDa, 1800-2000 kDa.

[0049] In certain embodiments of the application, the medium molecular weight hyaluronic acid has a weight average molecular weight of 200-600 Kda, for example 200-550 kDa, 200-500 kDa, 200-450 kDa, 200-400 kDa, 200-350 kDa, 200-300 kDa, 200-250 kDa, 250-550 kDa, 250-500 kDa, 250-450 kDa, 250-400 kDa, 250-350 kDa, 250-300 kDa, 300-550 kDa, 300-500 kDa, 300-450 kDa, 300-400 kDa, 300-350 kDa, 350-550 kDa, 350-500 kDa, 350-450 kDa, 350-400 kD.

[0050] In some embodiments of the present application, the low molecular weight hyaluronic acid has a weight average molecular weight of ≤ 10 KDa, such as 1-10 KDa, 1-9 KDa, 1-8 KDa, 1-7 KDa, 1-6 KDa, 1-5 KDa, 1-4 KDa, 1-3 KDa, 1-2 KDa, 2-10 KDa, 2-9 KDa, 2-8 KDa, 2-7 KDa, 2-6 KDa, 2-5 KDa, 2-4 KDa, 2-3 KDa, 3-10 KDa, 3-9 KDa, 3-8 KDa, 3-7 KDa, 3-6 KDa, 3-5 KDa, 3-4 KDa, 4-10 KDa, 4-9 KDa, 4-8 KDa, 4-7 KDa, 4-6 KDa, 4-5 KDa, 5-10 KDa, 5-9 KDa, 5-8 KDa, 5-7 KDa, 5-6 KDa, 6-10 KDa, 6-9 KDa, 6-8 KDa, 6-7 KDa, 7-10 KDa, 7-9 KDa, 7-8 KDa, 8-10 KDa, 8-9 KDa.

[0051] In some embodiments of the present application, the high molecular weight hyaluronic acid has a mass fraction of 20-30% in the hyaluronic acid, such as 20-28%, 20-25%, 20-22%, 22-30%, 22-28%, 22-25%, 25-30%, 25-28%, 28-30%.

[0052] In some embodiments of the present application, the medium molecular weight hyaluronic acid has a mass fraction of 30-50% in the hyaluronic acid, such as 30-48%, 30-45%, 30-42%, 30-40%, 30-38%, 30-35%, 30-33%, 33-50%, 33-48%, 33-48%, 33-45%, 33-42%, 33-40%, 33-38%, 33-35%, 35-50%, 35-48%, 35-45%, 35-42%, 35-40%, 35-38%, 38-50%, 38-48%, 38-45%, 38-42%, 38-40%, 40-50%, 40-48%, 40-45%, 40-42%, 43-50%, 43-48%, 43-45%, 45-50%, 45-48%.

[0053] In some embodiments of the present application, the low molecular weight hyaluronic acid has a mass fraction of 30-40% in the hyaluronic acid, such as 30-38%, 30-35%, 30-33%, 33-40%, 33-38%, 33-35%, 35-40%, 35-38%.

[0054] In certain embodiments of the present application, the hyaluronic acid is present in the oral care composition in an amount of from 0.001 to 3%, for example, but not limited to, from 0.005 to 3%, from 0.01 to 3%, from 0.03 to 3%, from 0.05 to 3%, from 0.08 to 3%, from 0.1 to 3%, from 0.2 to 3%, from 0.3 to 3%, from 0.5 to 3%, from 0.8 to 3%, from 1.0 to 3%, from 1.2 to 3%, from 1.5 to 3%, from 1.8 to 3%, from 2.0 to 3%, from 2.2 to 3%, from 2.5 to 3%, from 2.8 to 3%, from 0.001 to 2.8%, from 0.005 to 2.8%, from 0.01 to 2.8%, from 0.03 to 2.8%, from 0.05 to 2.8%, from 0.08 to 2.8%, from 0.1 to 2.8%, from 0.2.8 to 2.8%, from 0.5 to 2.8%, from 0.8 to 2.8%, from 1.0 to 2.8%, from 1.2 to 2.8%, from 1.5 to 2.8%, from 1.8 to 2.8%, from 2.0 to 2.8%, from 2.2 to 2.8%, from 2.5 to 2.8%, from 0.001 to 2.5%, from 0.005 to 2.5%, from 0.01 to 2.5%, from 0.03 to 2.5%, from 0.05 to 2.5%, from 0.08 to 2.5%, from 0.1 to 2.5%, from 0.2.5 to 2.5%, from 0.5 to 2.5%, from 0.8 to 2.5%, from 1.0 to 2.5%, from 1.2 to 2.5%, from 1.5 to 2.5%, from 1.8 to 2.5%, from 2.0 to 2.5%, from 2.2 to 2.5%, from 0.001 to 2.2%, from 0.005 to 2.2%, from 0.01 to 2.2%, from 0.03 to 2.2%, from 0.05 to 2.2%, from 0.08 to 2.2%, from 0.1 to 2.2%, from 0.2.2 to 2.2%, from 0.5 to 2.2%, from 0.8 to 2.2%, from 1.0 to 2.2%, from 1.2 to 2.2%, from 1.5 to 2.2%, from 1.8 to 2.2%, from 2.0 to 2.2%, from 0.001 to 2%, from 0.005 to 2%, from 0.01 to 2%, from 0.02 to 2%, from 0.05 to 2%, from 0.08 to 2%, from 0.1 to 2%, from 0.2 to 2%, from 0.5 to 2%, from 0.8 to 2%, from 1.0 to 2%, from 1.2 to 2%, from 1.5 to 2%, from 1.8 to 2%, from 0.001 to 1.8%, from 0.005 to 1.8%, from 0.01 to 1.8%, from 0.03 to 1.8%, from 0.05 to 1.8%, from 0.08 to 1.8%, from 0.1 to 1.8%, from 0.1.8 to 1.8%, from 0.5 to 1.8%, from 0.8 to 1.8%, from 1.0 to 1.8%, from 1.2 to 1.8%, from 1.5 to 1.8%, from 0.001 to 1.5%, from 0.005 to 1.5%, from 0.01 to 1.5%, from 0.03 to 1.5%, from 0.05 to 1.5%, from 0.08 to 1.5%, from 0.1 to 1.5%, from 0.1.5 to 1.5%, from 0.5 to 1.5%, from 0.8 to 1.5%, from 1.0 to 1.5%, from 1.2 to 1.5%, or from 0.001 to 1.2%.0.001-1.2%, 0.005-1.2%, 0.01-1.2%, 0.03-1.2%, 0.05-1.2%, 0.08-1.2%, 0.1-1.2%, 0.3-1.2%, 0.5-1.2%, 0.8-1.2%, 1.0-1.2%, 0.001-1%, 0.005-1.0%, 0.01-1.0%, 0.03-1.0%, 0.05-1.0%, 0.08-1.0%, 0.1-1.0%, 0.3-1.0%, 0.5-1.0%, 0.8-1.0%, 0.001-0.8%, 0.005-0.8%, 0.01-0.8%, 0.03-0.8%, 0.05-0.8%, 0.08-0.8%, 0.1-0.8%, 0.3-0.8%, 0.5-0.8%, 0.001-0.8%, 0.001-0.5%, 0.005-0.5%, 0.01-0.5%, 0.03-0.5%, 0.05-0.5%, 0.08-0.5%, 0.1-0.5%, 0.3-0.5%, 0.001-0.3%, 0.005-0.3%, 0.01-0.3%, 0.03-0.3%, 0.05-0.3%, 0.08-0.3%, 0.1-0.3%, 0.001-0.25%, 0.005-0.25%, 0.01-0.25%, 0.03-0.25%, 0.05-0.25%, 0.08-0.25%, 0.1-0.25%, 0.001-0.2%, 0.005-0.20%, 0.01-0.20%, 0.03-0.20%, 0.05-0.20%, 0.08-0.20%, 0.1-0.20%, 0.001-0.15%, 0.005-0.15%, 0.01-0.15%, 0.03-0.15%, 0.05-0.15%, 0.08-0.15%, 0.1-0.15%, 0.001-0.1%, 0.005-0.1%, 0.01-0.1%, 0.03-0.1%, 0.05-0.1%, 0.08-0.1%, 0.005-0.05%, 0.01-0.05%, 0.03-0.05%.

[0055] Coconut oil

[0056] Coconut oil is an edible oil extracted from the meat of mature coconuts and has multiple uses in food manufacturing, pharmaceuticals, industry, and personal care. It has been unexpectedly discovered that coconut oil can improve the stability of certain hyaluronic acids during high temperature preparation.

[0057] In certain embodiments of the present application, the coconut oil is present in the oral care composition in an amount of 0.01-5%, for example, but not limited to, 0.05-5%, 0.1-5%, 0.2-5%, 0.3-5%, 0.5-5%, 0.8%-5%, 1-5%, 2-5%, 2.5-5%, 3-5%, 3.5-5%, 4-5%, 4.5-5%, 0.01-4.5%, 0.05-4.5%, 0.1-4.5%, 0.2-4.5%, 0.3-4.5%, 0.5-4.5%, 0.8%-4.5%, 1-4.5%, 1.5-4.5%, 2-4.5%, 2.5-4.5%, 3-4.5%, 3.5-4.5%, 4-4.5%, 0.01-4%, 0.05-4%, 0.1-4%, 0.2-4%, 0.3-4%, 0.5-4%, 0.8%-4%, 1-4%, 1.5-4%, 2-4%, 2.5-4%, 3-4%, 3.5-4%, 0.01-3.5%, 0.05-3.5%, 0.1-3.5%, 0.2-3.5%, 0.3-3.5%, 0.5-3.5%, 0.8%-3.5%, 1-3.5%, 1.5-3.5%, 2-3.5%, 2.5-3.5%, 3-3.5%, 0.01-3%, 0.05-3%, 0.1-3%, 0.2-3%, 0.3-3%, 0.5-3%, 0.8%-3%, 1-3%, 1.5-3%, 2-3%, 2.5-3%, 0.01-2.5%, 0.05-2.5%, 0.1-2.5%, 0.2-2.5%, 0.3-2.5%, 0.5-2.5%, 0.8%-2.5%, 1-2.5%, 1.5-2.5%, 2-2.5%, 0.01-2%, 0.05-2%, 0.1-2%, 0.2-2%, 0.3-2%, 0.5-2%, 0.8%-2%, 1-2%, 1.5-2%, 0.01-1.5%, 0.05-1.5%, 0.1-1.5%, 0.2-1.5%, 0.3-1.5%, 0.5-1.5%, 0.8%-1.5%, 1-1.5%.

[0058] In some embodiments of the present invention, the mass ratio of hyaluronic acid to coconut oil in the oral care composition is 100:1 to 1:100, for example 100:1 to 1:80, 100:1 to 1:50, 100:1 to 1:30, 100:1 to 1:20, 100:1 to 1:10, 100:1 to 1:5, 100:1 to 1:4.5, 100:1 to 1:4.0, 100:1 to 1:3.5, 100:1 to 1:3, 100:1 to 1:2.5, 100:1 to 1:2, 100:1 to 1:1.5, 80:1 to 1:100, 80:1 to 1:80, 80:1 to 1:50, 80:1 to 1:30, 80:1 to 1:20, 80: 1-1:10, 80:1-1:5, 80:1-1:4.5, 80:1-1:4.0, 80:1-1:3.5, 80:1-1:3, 80:1-1:2.5, 80:1-1:2, 80:1-1:1.5, 50:1-1:100, 50:1-1:50, 50:1-1:30, 50:1 -1:20, 50:1-1:10, 50:1-1:5, 50:1-1:4.5, 50:1-1:4.0, 50:1-1:3.5, 50:1-1:3, 50:1-1:2.5, 50:1-1:2, 50:1-1:1.5, 20:1-1:100, 20:1-1:80, 20:1-1 :50, 20:1-1:30, 20:1-1:20, 20:1-1:10, 20:1-1:5, 20:1-1:4.5, 20:1-1:4.0, 20:1-1:3.5, 20:1-1:3, 20:1-1:2.5, 20:1-1:2, 20:1-1:1.5, 10:1-1:1 00, 10:1-1:80, 10:1-1:50, 10:1-1:30, 10:1-1:20, 10:1-1:10, 10:1-1:5, 10:1-1:4.5, 10:1-1:4.0, 10:1-1:3.5, 10:1-1:3, 10:1-1:2.5, 10:1-1:2, 1 0:1-1:1.5, 5:1-1:100, 50:1-1:80, 5:1-1:50, 5:1-1:30, 5:1-1:20, 5:1-1:10, 5:1-1:5, 5:1-1:4.5, 5:1-1:4.0, 5:1-1:3.5, 5:1-1:3, 5:1-1:2.5, 5: 1-1:2, 5:1-1:1.5, 1:1-1:100, 1:1-1:80, 1:1-1:50, 1:1-1:30, 1:1-1:20, 1:1-1:10, 1:1-1:5, 1:1-1:4.5, 1:1-1:4.0, 1:1-1:3.5, 1:1-1:3, 1:1-1:2.5, 1 : 1 - 1 : 2, 1 : 1 - 1 : 1.5, 1 : 1.5 - 1 : 5, 1 : 1.5 - 1 : 4.5, 1 : 1.5 - 1 : 40, 1 : 1.5 - 1 : 3.5, 1 : 1.5 - 1 : 3, 1 : 1.5 - 1 : 2.5, 1 : 1.5 - 1 : 2, 1 : 1.5 - 1 : 5, 1.5 - 1 : 4.5, 1 : 1.5 - 1 : 4.0, 1 : 1.5 - 1 : 3.5, 1 : 1.5 - 1 : 3, 1 : 1.5 - 1 : 2.5, 1 : 1.5 - 1 : 2, 1 : 2 - 1 : 5, 1 : 2 - 1 : 4.5, 1 : 2 - 1 : 40, 1 : 2 - 1 : 3.5, 1 : 2 - 1 : 3, 1 : 2 - 1 : 2.5, 1 : 2 - 1 : 2, 1 : 2 - 1 : 5, 1 : 2 - 1 : 4.5, 1 : 2 - 1 : 4.0, 1 : 2 - 1 : 3.5, 1 : 2 - 1 : 3, 1 : 2 - 1 : 2.5, 1 : 2.5 - 1 : 5, 1 : 2.5 - 1 : 4.5, 1 : 2.5 - 1 : 4.0, 1 : 2.5 - 1 : 3.5, 1 : 2.5 - 1 : 3, 1 : 3 - 1 : 5, 1 : 3 - 1 : 4.5, 1 : 3 - 1 : 4.0, 1 : 3 - 1 : 3.5, 1 : 3.5 - 1 : 5, 1 : 3.5 - 1 : 4.5, 1 : 3.5 - 1 : 4.0, 1 : 4 - 1 : 5, 1 : 4 - 1 : 4.5.

[0059] Soluble zinc salt

[0060] "Soluble zinc salt" refers to a zinc salt that is capable of existing in a solvent (e.g., water) or a matrix (e.g., toothpaste) without existing as a precipitate, as distinguished from a zinc salt that exists as an insoluble solid, such as solid zinc oxide. The soluble zinc salt can include zinc salts that exist in ionic form, in complex, chelate form, and in dispersible combinations when dispersed in a solvent or matrix, such as, but not limited to, one or more combinations of zinc citrate, zinc citrate trihydrate, zinc sulfate, zinc nitrate, zinc chloride, zinc gluconate.

[0061] In certain embodiments of the present application, the soluble zinc salt can be measured for soluble zinc concentration by methods known to those skilled in the art, such as atomic absorption spectroscopy, inductively coupled plasma emission spectroscopy, and the like.

[0062] In certain embodiments of the present application, the soluble zinc salt is present in the oral care composition in an amount of from 0.01 to 5%, for example, but not limited to, from 0.05 to 5%, from 0.1 to 5%, from 0.2 to 5%, from 0.3 to 5%, from 0.5 to 5%, from 0.8% to 5%, from 1 to 5%, from 2 to 5%, from 2.5 to 5%, from 3 to 5%, from 3.5 to 5%, from 4 to 5%, from 4.5 to 5%, from 0.01 to 4.5%, from 0.05 to 4.5%, from 0.1 to 4.5%, from 0.2 to 4.5%, from 0.3 to 4.5%, from 0.5 to 4.5%, from 0.8% to 4.5%, from 1 to 4.5%, from 1.5 to 4.5%, from 2 to 4.5%, from 2.5 to 4.5%, from 3 to 4.5%, from 3.5 to 4.5%, from 4 to 4.5%, from 0.01 to 4%, from 0.05 to 4%, from 0.1 to 4%, from 0.2 to 4%, from 0.3 to 4%, from 0.5 to 4%, from 0.8% to 4%, from 1 to 4%, from 1.5 to 4%, from 2 to 4%, from 2.5 to 4%, from 3 to 4%, from 3.5 to 4%, from 0.01 to 3.5%, from 0.05 to 3.5%, from 0.1 to 3.5%, from 0.2 to 3.5%, from 0.3 to 3.5%, from 0.5 to 3.5%, from 0.8% to 3.5%, from 1 to 3.5%, from 1.5 to 3.5%, from 2 to 3.5%, from 2.5 to 3.5%, from 3 to 3.5%, from 0.01 to 3%, from 0.05 to 3%, from 0.1 to 3%, from 0.2 to 3%, from 0.3 to 3%, from 0.5 to 3%, from 0.8% to 3%, from 1 to 3%, from 1.5 to 3%, from 2 to 3%, from 2.5 to 3%, from 0.01 to 2.5%, from 0.05 to 2.5%, from 0.1 to 2.5%, from 0.2 to 2.5%, from 0.3 to 2.5%, from 0.5 to 2.5%, from 0.8% to 2.5%, from 1 to 2.5%, from 1.5 to 2.5%, from 2 to 2.5%, from 0.01 to 2%, from 0.05 to 2%, from 0.1 to 2%, from 0.2 to 2%, from 0.3 to 2%, from 0.5 to 2%, from 0.8% to 2%, from 1 to 2%, from 1.5 to 2%, from 0.01 to 1.5%, from 0.05 to 1.5%, from 0.1 to 1.5%, from 0.2 to 1.5%, from 0.3 to 1.5%, from 0.5 to 1.5%, from 0.8% to 1.5%, from 1 to 1.5%.

[0063] Other orally acceptable carriers

[0064] In certain embodiments of the present application, the oral care composition is a liquid toothpaste or mouthwash.

[0065] In the present invention, the "orally acceptable carrier" means any vehicle suitable for formulating the oral care composition disclosed in the present invention; is not harmful to mammals when retained in the mouth without being swallowed for a period of time sufficient to allow effective contact with the dental surfaces as required in the present invention; in general, the orally acceptable carrier is not harmful even if swallowed unintentionally; suitable orally acceptable carriers include, for example, one or more of the following: water, abrasives, surfactants, thickening agents, pH adjusting agents, humectants, flavoring agents, visual aids (e.g., pigments, dyes or mixtures thereof), anti-caries agents, antibacterial agents, whitening agents, desensitizing agents, preservatives, and mixtures thereof, and the like.

[0066] As another aspect of the present invention, the present invention provides the use of coconut oil in improving the stability of hyaluronic acid in an oral care composition during high temperature preparation process.

[0067] As yet another aspect of the present invention, the present invention provides the use of the above-mentioned oral care composition comprising hyaluronic acid and coconut oil in improving dry mouth.

[0068] As still another aspect of the present invention, the present invention provides the use of the above-mentioned oral care composition comprising hyaluronic acid and coconut oil in reducing the astringency of zinc ions. Specific embodiments

[0070] HA-1 to HA-9 are hyaluronic acid raw materials used in the examples

[0071] Table 1 is nine different hyaluronic acid raw materials comprising different molecular weight ranges.

[0072] Table 1: (The percentages in the table are weight ratios)

[0073] HA-1 HA-2 HA-3 HA-4 HA-5 HA-6 HA-7 HA-8 HA-9 0-10 kDa 35％ / 50％ 50％ 30％ / / 30％ 30％ 20-180 kDa / / / / 40％ 40％ 40％ 30％ / 200-600 kDa 35％ 50％ 50％ / / 30％ / 40％ 40％ 700-800 kDa / / / / 30％ 30％ 30％ / 30％ ≥ 1000 kDa 30％ 50％ / 50％ / / 30％ / /

[0074] That is, the coconut oil is used in the present invention to improve the stability of hyaluronic acid in an oral care composition during high temperature preparation process.

[0075] HA-1 is a raw material comprising 35% low molecular weight hyaluronic acid having a weight average molecular weight of 0-10 kDa, 35% medium molecular weight hyaluronic acid having a weight average molecular weight of 200-600 kDa, and 30% high molecular weight hyaluronic acid having a weight average molecular weight of ≥ 1000 kDa;

[0076] HA-2 is a raw material comprising 50% hyaluronic acid having a weight average molecular weight of 200-600 kDa, and 50% hyaluronic acid having a weight average molecular weight of 700-800 kDa;

[0077] HA-3 is a raw material comprising 50% low molecular weight hyaluronic acid having a weight average molecular weight of 0-10 kDa, and 50% medium molecular weight hyaluronic acid having a weight average molecular weight of 200-600 kDa;

[0078] HA-4 is a raw material comprising 50% of low molecular weight hyaluronic acid having a weight average molecular weight of 0-10 kDa, 50% of medium molecular weight hyaluronic acid having a weight average molecular weight of 200-600 kDa, and 30% of high molecular weight hyaluronic acid having a weight average molecular weight of ≥ 1000 kDa;

[0079] HA-5 is a raw material comprising 30% of molecular weight hyaluronic acid having a weight average molecular weight of 0-10 kDa, 40% of molecular weight hyaluronic acid having a weight average molecular weight of 20-180 kDa, and 30% of molecular weight hyaluronic acid having a weight average molecular weight of 700-800 kDa;

[0080] HA-6 is a raw material comprising 40% of medium low molecular weight hyaluronic acid having a weight average molecular weight of 200-600 kDa, and 30% of high molecular weight hyaluronic acid having a weight average molecular weight of ≥ 1000 kDa;

[0081] HA-7 is a raw material comprising 40% of medium low molecular weight hyaluronic acid having a weight average molecular weight of 20-180 kDa, 30% of hyaluronic acid having a weight average molecular weight of 700-800 kDa, and 30% of high molecular weight hyaluronic acid having a weight average molecular weight of ≥ 1000 kDa;

[0082] HA-8 is a raw material comprising 30% of molecular weight hyaluronic acid having a weight average molecular weight of 0-10 kDa, 30% of molecular weight hyaluronic acid having a weight average molecular weight of 20-180 kDa, and 40% of molecular weight hyaluronic acid having a weight average molecular weight of 200-600 kDa;

[0083] HA-9 is a raw material comprising 30% of low molecular weight hyaluronic acid having a weight average molecular weight of 0-10 kDa, 40% of medium low molecular weight hyaluronic acid having a weight average molecular weight of 200-600 kDa, and 30% of high molecular weight hyaluronic acid having a weight average molecular weight of 700-800 kDa;

[0084] Method for characterizing the stability of hyaluronic acid

[0085] The change in kinematic viscosity of 0.1 wt% concentration of hyaluronic acid at room temperature and at 70°C was detected, and the greater the change in viscosity, the more unstable it was. The unit of kinematic viscosity was mm 2 / s.

[0086] Comparative example 1

[0087] Comparative Example 1 was prepared according to Table 2 at room temperature (25°C) so that the concentration of hyaluronic acid was 0.1%.

[0088] Table 2

[0089] Raw material name Comparative example 1 HA-1 0.1 Deionized water Added to 100%

[0090] Comparative example 2

[0091] Prepare Comparative Example 2 by replacing HA-1 in Table 2 with HA-2.

[0092] Comparative example 3

[0093] Prepare Comparative Example 3 by replacing HA-1 in Table 2 with HA-3.

[0094] Comparative example 4

[0095] Prepare Comparative Example 4 by replacing HA-1 in Table 2 with HA-4.

[0096] Comparative example 5

[0097] Prepare Comparative Example 5 by replacing HA-1 in Table 2 with HA-5.

[0098] Comparative example 6

[0099] Prepare Comparative Example 6 by replacing HA-1 in Table 2 with HA-6.

[0100] Comparative example 7

[0101] Prepare Comparative Example 7 by replacing HA-1 in Table 2 with HA-7.

[0102] Comparative example 8

[0103] Prepare Comparative Example 8 by replacing HA-1 in Table 2 with HA-8.

[0104] Comparative example 9

[0105] Prepare Comparative Example 9 by replacing HA-1 in Table 2 with HA-9.

[0106] A. Test the kinematic viscosity of the compositions of Comparative Examples 1-9 at room temperature. The data are shown in Table 3 below:

[0107] Table 3

[0108]

[0109] As can be seen from Table 3, the kinematic viscosities of the formulations of Comparative Examples 1-9 are similar at room temperature.

[0110] B. Stir Comparative Examples 1-9 at 70°C for 2h, and cool to room temperature, and test the kinematic viscosity. The data are shown in Table 4 below:

[0111] Table 4

[0112]

[0113] As can be seen from Table 4, the kinematic viscosity of the hyaluronic acid solution of Comparative Examples 1 to 9, which was stirred at 70°C for 2h and then cooled to room temperature, was greatly decreased.

[0114] Example 1

[0115] Example 1 was prepared according to Table 5 at room temperature (25°C).

[0116] Table 5

[0117] Raw material name Example 1 HA-1 0.1 Coconut oil 0.01 Deionized water Added to 100%

[0118] As can be seen from Table 5, Example 1 was prepared by adding 0.01% of coconut oil to Comparative Example 1.

[0119] Comparative example 10

[0120] Comparative Example 10 was prepared by adding 0.01% of coconut oil to Comparative Example 2.

[0121] Comparative example 11

[0122] Comparative Example 11 was prepared by adding 0.01% of coconut oil to Comparative Example 3.

[0123] Comparative example 12

[0124] Comparative Example 12 was prepared by adding 0.01% of coconut oil to Comparative Example 4.

[0125] Comparative example 13

[0126] Comparative Example 13 was prepared by adding 0.01% of coconut oil to Comparative Example 5.

[0127] Comparative example 14

[0128] Comparative Example 14 was prepared by adding 0.01% of coconut oil to Comparative Example 6.

[0129] Comparative example 15

[0130] Comparative Example 15 was prepared by adding 0.01% of coconut oil to Comparative Example 7.

[0131] Comparative example 16

[0132] Comparative Example 16 was prepared by adding 0.01% of coconut oil to Comparative Example 8.

[0133] Comparative example 17

[0134] Comparative Example 17 is based on Comparative Example 9 with the addition of 0.01% coconut oil.

[0135] A. The kinematic viscosity of Example 1 and Comparative Examples 10-17 at room temperature is shown in Table 6 below:

[0136] Table 6

[0137]

[0138] As can be seen from Table 6, the kinematic viscosity of the hyaluronic acid solutions of Example 1 and Comparative Examples 10-17 increased after the addition of coconut oil, but the increase was small.

[0139] B. The kinematic viscosity of Example 1 and Comparative Examples 10-17 after stirring at 70°C for 2h and cooling to room temperature is shown in Table 7 below:

[0140] Table 7

[0141]

[0142] As can be seen from Table 7, the kinematic viscosity of the formulations of Comparative Examples 10-17 decreased significantly after stirring at 70°C for 2h and cooling to room temperature. Even with the addition of coconut oil, the hyaluronic acid of Comparative Examples 10-17 was still unstable at high temperatures. The kinematic viscosity of Example 1 did not change significantly after stirring at 70°C for 2h and cooling to room temperature. Thus, the coconut oil has a strong stabilizing effect on the HA1 type of hyaluronic acid.

[0143] HA-10 to HA-16 hyaluronic acid raw materials are listed in the following table 8:

[0144] Table 8: (The percentages in the table are weight percentages)

[0145] Molecular weight HA-10 HA-11 HA-12 HA-13 HA-14 HA-15 HA-16 0-10,000 40％ 40％ 30％ 20％ 50％ 30％ 40％ 20-600,000 40％ 30％ 40％ 40％ 30％ 30％ 50％ ≥ 10 million 20％ 30％ 30％ 40％ 20％ 40％ 10％

[0146] As can be seen from Table 8, the HA-10 to HA-16 hyaluronic acid raw materials have the same molecular weight range, but the mass percentage of each molecular weight range in the hyaluronic acid is different.

[0147] Example 2

[0148] Example 2 is prepared by replacing HA-1 in the formulation of Example 1 with HA-10.

[0149] Example 3

[0150] Example 3 is prepared by replacing HA-1 in the formulation of Example 1 with HA-11.

[0151] Example 4

[0152] Example 4 was prepared by replacing HA-1 in the formulation of Example 1 with HA-12.

[0153] Comparative example 18

[0154] Comparative Example 19 was prepared by replacing HA-1 in the formulation of Example 1 with HA-14.

[0155] Comparative example 19

[0156] Comparative Example 19 was prepared by replacing HA-1 in the formulation of Example 1 with HA-14.

[0157] Comparative example 20

[0158] Comparative Example 20 was prepared by replacing HA-1 in the formulation of Example 1 with HA-15.

[0159] Comparative example 21

[0160] Comparative Example 21 was prepared by replacing HA-1 in the formulation of Example 1 with HA-16.

[0161] A. The kinematic viscosity of Examples 2-4 and Comparative Examples 18-21 at room temperature was detected. For easy comparison, the viscosity of Example 1 is listed in Table 9 below:

[0162] Table 9

[0163]

[0164] As can be seen from Table 9, the kinematic viscosity of the formulations of Examples 1-4 and Comparative Examples 18-21 at room temperature is similar.

[0165] B. Examples 2-4 and Comparative Examples 18-21 were stirred at 70°C for 2h and cooled to room temperature, and the kinematic viscosity was detected.

[0166] Table 10:

[0167]

[0168] As can be seen from Table 10, the kinematic viscosity of the hyaluronic acid formulations of Examples 2-4 is stable after being stirred at 70°C for 2h and cooled to room temperature; while the kinematic viscosity of the hyaluronic acid formulations of Comparative Examples 18-21 decreases greatly after being stirred at 70°C for 2h and cooled to room temperature. That is, coconut oil has a good stabilizing effect on hyaluronic acid with a mass ratio of 20-30% of high molecular weight (≥ 1 million), 30-50% of medium molecular weight (20-600 million), and 30-40% of low molecular weight (less than 1 million).

[0169] Examples 5-9

[0170] Examples 5-9 were prepared according to Table 11 at room temperature (25°C), and for the convenience of comparison, the formulation of Example 1 was also listed in Table 11.

[0171] Table 11:

[0172]

[0173] From Table 11, it can be seen that Examples 1, 5-9 all added hyaluronic acid HA-1 and coconut oil, but the mass concentration ratios of the two in the formulations were different; among them:

[0174] The mass concentration ratio of HA-1 to coconut oil in the formulation of Example 5 was 100:1;

[0175] The mass concentration ratio of HA-1 to coconut oil in the formulation of Example 6 was 20:1;

[0176] The mass concentration ratio of HA-1 to coconut oil in the formulation of Example 1 was 10:1;

[0177] The mass concentration ratio of HA-1 to coconut oil in the formulation of Example 7 was 1:1;

[0178] The mass concentration ratio of HA-1 to coconut oil in the formulation of Example 8 was 1:10;

[0179] The mass concentration ratio of HA-1 to coconut oil in the formulation of Example 9 was 1:12;

[0180] At the same time, the surfactant sodium dodecyl sulfate was also added in the formulation of Example 9, so that the coconut oil was fully dispersed in water.

[0181] A. The kinematic viscosity of Examples 5-9 at room temperature was detected, and the data are shown in Table 12:

[0182] Table 12

[0183]

[0184] From Table 12, it can be seen that the kinematic viscosities of the formulations of Examples 5-8 at room temperature were similar.

[0185] B. Examples 5-8 were stirred at 70°C for 2h and cooled to room temperature, and the kinematic viscosity was detected, and the data are shown in Table 13.

[0186] Table 13:

[0187] Raw material name Example 5 Example 6 Example 1 Example 7 Example 8 Example 9 Kinematic viscosity 9.7 12.5 14.9 14.8 15 15.1

[0188] As can be seen from Table 13, although the formulation of Example 5 only added 0.005% of coconut oil to the 0.1% mass concentration of hyaluronic acid, i.e. the concentration ratio of hyaluronic acid and coconut oil in the formulation was 100:1, the kinematic viscosity of the formulation after high-temperature stirring was still significantly improved compared with Comparative Example 1; when the concentration ratio of hyaluronic acid and coconut oil in the formulation of Example 6 was 20:1, the kinematic viscosity was improved compared with Example 5; when the concentration ratio of hyaluronic acid and coconut oil in the formulations of Examples 1, 7-9 was increased from 10:1 to 1:12, the kinematic viscosity of the hyaluronic acid after high-temperature was further improved compared with Example 6, and the kinematic viscosity remained stable with the increase of the concentration of coconut oil.

[0189] Although the mass ratio of hyaluronic acid and coconut oil in the above examples is only in the range of 100:1-1:12, but increasing the mass ratio of coconut oil can still improve the kinematic viscosity of hyaluronic acid after high temperature (70°C), for example, increasing the mass ratio of hyaluronic acid and coconut oil to between 100:1-1:100, and increasing the concentration of coconut oil to 1.5-3%.

[0190] Although the concentration of hyaluronic acid in the listed examples is all 0.1%, but increasing the concentration of hyaluronic acid, coconut oil can still improve the kinematic viscosity of hyaluronic acid after high temperature, for example, increasing the concentration of hyaluronic acid to 0.2%-5%.

[0191] Method for evaluating the improvement of oral dryness according to the invention :

[0192] 30 subjects were recruited, and the test samples were used after breakfast or lunch, with at least 30 minutes interval between each two samples, and no more than 3 samples per day;

[0193] The specific method is as follows: before using the test sample, first rinse the mouth with water, the method of rinsing the mouth is to hold water in the mouth, stimulate both cheeks, so that the water can fully contact the teeth and gums in the oral cavity, and repeatedly wash each part of the oral cavity to remove as much food residue as possible in the oral cavity. The method of using the test sample is to take 1g of sample and brush the teeth for 1 minute.

[0194] The sensory evaluation includes the comfort of the taste during brushing (whether there is a taste, irritation), the moisture and lubricity of the oral cavity after brushing, and whether the saliva is abundant, which are filled in the evaluation table. The evaluation reference is that the sensory evaluation score is 5 points, 5 points is the best effect, the taste is comfortable, the moisture and lubricity are good, and the saliva is abundant, and the effect decreases in turn as 4, 3, 2, 1, 1 point is the worst effect, the taste is poor, there is irritation, the mouth is dry after brushing, the mouth is dry, the lubricity is poor.

[0195] Example 10, Comparative Examples 22-24

[0196] Example 10, Comparative Examples 22-24 were prepared according to Table 14 and subjects were recruited.

[0197] Table 14:

[0198]

[0199] As can be seen from Table 14, when only HA-1 hyaluronic acid was added to the formulation of Comparative Example 22, the score increased from 1.1 to 1.6, and when only coconut oil was added to the formulation of Comparative Example 23, the score increased from 1.1 to 1.4, i.e. both HA-1 hyaluronic acid and coconut oil had some effect on the relief of dry mouth, but when both HA-1 hyaluronic acid and coconut oil were added to the formulation of Example 10, the score increased to 3.7, i.e. the combination of HA-1 and coconut oil had a synergistic effect on the relief of dry mouth when both were included in the formulation.

[0200] Comparative example 25

[0201] Comparative Example 25 was prepared by replacing HA-1 in the formulation of Example 10 with HA-2.

[0202] Comparative example 26

[0203] Comparative Example 26 was prepared by replacing HA-1 in the formulation of Example 10 with HA-3.

[0204] Comparative example 27

[0205] Comparative Example 27 was prepared by replacing HA-1 in the formulation of Example 10 with HA-4.

[0206] Comparative example 28

[0207] Comparative Example 28 was prepared by replacing HA-1 in the formulation of Example 10 with HA-5.

[0208] Comparative example 29

[0209] Comparative Example 29 was prepared by replacing HA-1 in the formulation of Example 10 with HA-6.

[0210] Comparative example 30

[0211] Comparative Example 30 was prepared by replacing HA-1 in the formulation of Example 10 with HA-7.

[0212] Comparative example 31

[0213] Comparative Example 31 was prepared by replacing HA-1 in the formulation of Example 10 with HA-8.

[0214] Comparative example 32

[0215] Example 10 was prepared by replacing HA-1 with HA-9 to give Comparative Example 32.

[0216] The compositions of Comparative Examples 25-32 were evaluated for improvement of dry mouth, as shown in Table 12 below:

[0217] Table 15

[0218]

[0219] As can be seen from Table 15, the formulations of Comparative Examples 25-32, although both added hyaluronic acid and coconut oil, did not improve dry mouth as well as Example 10.

[0220] Example 11

[0221] Example 10 was prepared by replacing HA-1 with HA-10 to give Example 11.

[0222] Example 12

[0223] Example 10 was prepared by replacing HA-1 with HA-11 to give Example 12.

[0224] Example 13

[0225] Example 10 was prepared by replacing HA-1 with HA-12 to give Example 13.

[0226] Example 14

[0227] Example 10 was prepared by replacing HA-1 with HA-13 to give Example 14.

[0228] Example 15

[0229] Example 10 was prepared by replacing HA-1 with HA-14 to give Example 15.

[0230] Example 16

[0231] Example 10 was prepared by replacing HA-1 with HA-15 to give Example 16.

[0232] Example 17

[0233] Example 10 was prepared by replacing HA-1 with HA-16 to give Example 17.

[0234] The compositions of Examples 11-17 were evaluated for improvement of dry mouth, as shown in Table 13 below:

[0235] Table 16:

[0236]

[0237] Table 16 combined with the evaluation score of Example 10 can be concluded that when the hyaluronic acid contains high, medium and low molecular weight segments of hyaluronic acid, and at the same time meets the requirements of high molecular weight hyaluronic acid with weight average molecular weight ≥1000KDa, medium molecular weight hyaluronic acid with weight average molecular weight of 200-600Kda, and low molecular weight hyaluronic acid with weight average molecular weight ≤10Kda, and the formula contains both hyaluronic acid and coconut oil, the oral dryness symptoms can be effectively improved, especially when the mass fraction of high molecular weight hyaluronic acid in hyaluronic acid is 20-30%, the mass fraction of medium molecular weight hyaluronic acid in hyaluronic acid is 30-50%, and the mass fraction of low molecular weight hyaluronic acid in hyaluronic acid is 30-40%, the oral dryness improvement effect is better.

[0238] Method for evaluating the astringent mouthfeel

[0239] 1) Evaluation team establishment

[0240] 30 qualified sensory evaluators were selected according to GB / T 16291.1—2012 and GB / T12311-2012;

[0241] 2) Calibration of the evaluation standard for astringency by the evaluators

[0242] 0.010g, 0.025g, and 0.05g of grape tannin were accurately weighed, added to 500ml of pure water, stirred until uniform, and then diluted with pure water to 1L. The astringency intensities were 2, 7, and 13, respectively, and the astringency intensity of water was 0.

[0243] 20mL of each of the above reference sample solutions was taken, and after thoroughly gargling for 30s, it was spit out (without using clean water to gargle). The astringency intensity inside the cavity at this time was evaluated, and the evaluators evaluated it on a 15cm scale according to their own feelings. The above steps were repeated three times for each reference sample, and the average value of the three results was taken to make the evaluators remember their own evaluation intensity. Then, according to the comprehensive rescaling method specified in the value estimation method of GB_T 19547-2004, the evaluation results of each evaluator for the reference sample were calculated to obtain the correction factor.

[0244] 3) Sample evaluation

[0245] 1g of the sample was taken and thoroughly brushed for 1min, and the astringency intensity inside the cavity at this time was evaluated. Each evaluator evaluated it on a 15cm scale according to their own feelings. The scale values of the thirty evaluators were corrected by the above correction value, and the evaluation results obtained by variance analysis were statistically different.

[0246] Example 18, comparative example 23

[0247] Example 18, Comparative Example 33 were prepared according to Table 17, Comparative Example 22, Comparative Example 24 were also listed in Table 17 for comparison.

[0248] Table 17

[0249]

[0250] From Table 17, it can be seen that Comparative Example 22 added 0.01% HA-1 to Comparative Example 24, the astringency score was reduced from 13 to 11.1, i.e. hyaluronic acid HA-1 has a certain effect of reducing the astringency of zinc ions.

[0251] Comparative Example 33 added 0.1% coconut oil to Comparative Example 10, but the astringency of the composition did not decrease.

[0252] Example 18 added 0.01% hyaluronic acid and 0.1% coconut oil to Comparative Example 24 at the same time, the astringency score was reduced from 13 to 7.8, which was significantly lower than that of Comparative Example 24, i.e. the composition with both hyaluronic acid HA-1 and coconut oil can significantly reduce the astringency of zinc ions.

[0253] Examples 19-25, comparative examples 34-41

[0254] Examples 19-20 and Comparative Examples 34-41 were based on Example 18, in which HA-1 was replaced by other types of hyaluronic acid, and the astringency of the composition was evaluated, and the data are shown in Tables 18 and 19, respectively:

[0255] Table 18: Astringency evaluation of the composition of Examples 19-25

[0256]

[0257] Table 19: Astringency evaluation of the composition of Comparative Examples 34-41

[0258]

[0259] It can be concluded from the evaluation scores in Table 18, Table 19 and Example 18 that hyaluronic acid has a certain effect of reducing the astringency of zinc, but when the hyaluronic acid contains high, medium and low molecular weight segments of hyaluronic acid, and at the same time the weight average molecular weight of the high molecular weight hyaluronic acid is ≥1000KDa, the weight average molecular weight of the medium molecular weight hyaluronic acid is 200-600Kda, and the weight average molecular weight of the low molecular weight hyaluronic acid is ≤10Kda, and the formula contains both hyaluronic acid and coconut oil, the astringency of the composition is significantly reduced, especially when the mass fraction of high molecular weight hyaluronic acid in the hyaluronic acid is 20-30%, the mass fraction of medium molecular weight hyaluronic acid in the hyaluronic acid is 30-50%, and the mass fraction of low molecular weight hyaluronic acid in the hyaluronic acid is 30-40%, the effect of improving the astringency of the zinc-containing composition is better.

[0260] Obviously, the above-mentioned embodiments of the present application are only examples for clearly illustrating the present application, and are not intended to limit the embodiments of the present application. Based on the above description, other different forms of changes or variations can be made by those skilled in the art. It is impossible to enumerate all the embodiments here. Any obvious changes or variations derived from the technical solutions of the present application are still within the protection scope of the present application.

Claims

1. An oral care composition comprising hyaluronic acid and coconut oil, characterized in that, Comprising: 1) hyaluronic acid; 2) coconut oil; 3) an orally acceptable carrier; wherein the hyaluronic acid comprises high molecular weight hyaluronic acid, medium molecular weight hyaluronic acid, and low molecular weight hyaluronic acid; the high molecular weight hyaluronic acid has a weight average molecular weight of > 1000 KDa, the medium molecular weight hyaluronic acid has a weight average molecular weight of 200-600 Kda, and the low molecular weight hyaluronic acid has a weight average molecular weight of < 10 KDa; the high molecular weight hyaluronic acid has a mass percentage of 20-30% in the hyaluronic acid, the medium molecular weight hyaluronic acid has a mass percentage of 30-50% in the hyaluronic acid, and the low molecular weight hyaluronic acid has a mass percentage of 30-40% in the hyaluronic acid; the oral care composition is subjected to a high temperature of 70°C during preparation.

2. The oral care composition of claim 1, characterized in that: the hyaluronic acid has a mass percentage of 0.001-3% in the oral care composition.

3. The oral care composition of claim 2, wherein: the hyaluronic acid has a mass percentage of 0.01-3% in the oral care composition.

4. The oral care composition of claim 1, wherein: the coconut oil has a mass percentage of 0.001-5% in the oral care composition.

5. The oral care composition of claim 4, wherein: the coconut oil has a mass percentage of 0.01-5% in the oral care composition.

6. The oral care composition of claim 1, wherein: the mass ratio of the hyaluronic acid and the coconut oil in the oral care composition is 100:1-1:

100.

7. The oral care composition of claim 1, wherein: the oral care composition further comprises a soluble zinc salt.

8. The oral care composition according to claim 7, characterized in that: the soluble zinc salt is derived from one or more of zinc citrate, zinc sulfate, zinc nitrate, zinc chloride, and zinc gluconate.

9. The oral care composition according to claim 8, characterized in that: the soluble zinc salt is zinc citrate.

10. The oral care composition of claim 1, characterized in that: the oral care composition is mouthwash or liquid toothpaste.

11. Use of coconut oil to improve the stability of hyaluronic acid in an oral care composition during high temperature manufacturing process, characterized in that: the hyaluronic acid comprises high molecular weight hyaluronic acid, medium molecular weight hyaluronic acid, and low molecular weight hyaluronic acid; the high molecular weight hyaluronic acid has a weight average molecular weight of > 1000 KDa, the medium molecular weight hyaluronic acid has a weight average molecular weight of 200-600 Kda, and the low molecular weight hyaluronic acid has a weight average molecular weight of < 10 KDa; the high molecular weight hyaluronic acid has a mass percentage of 20-30% in the hyaluronic acid, the medium molecular weight hyaluronic acid has a mass percentage of 30-50% in the hyaluronic acid, and the low molecular weight hyaluronic acid has a mass percentage of 30-40% in the hyaluronic acid; the oral care composition is subjected to a high temperature of 70°C during preparation.

12. Use of the oral care composition according to any one of claims 1-10 in the preparation of a product for improving dry mouth.

13. Use of the oral care composition according to any one of claims 1-10 in the preparation of a product for reducing the astringency of zinc ions.

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