Nitrogen-containing heterocyclic compounds, methods for their preparation, and uses thereof
By designing nitrogen-containing heterocyclic compounds of general formula (I) as RIPK1 kinase inhibitors, the shortcomings of existing inhibitors in terms of selectivity and pharmacokinetic properties have been overcome, achieving effective inhibition and therapeutic effects on RIPK1 kinase.
CN116265452BActive Publication Date: 2026-06-09SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES
- Filing Date
- 2022-12-15
- Publication Date
- 2026-06-09
AI Technical Summary
Technical Problem
Existing RIPK1 kinase inhibitors have shortcomings in terms of selectivity, in vivo inhibitory activity, and pharmacokinetics, and cannot effectively cross the blood-brain barrier, which limits their application in the treatment of necrotizing apoptosis-related diseases.
Method used
A nitrogen-containing heterocyclic compound of general formula (I) was developed as a novel kinase inhibitor for targeting RIPK1 kinase, with enhanced selectivity and pharmacokinetic properties through specific structural design.
Benefits of technology
This compound can effectively inhibit RIPK1 kinase, has better selectivity and pharmacokinetics, and can cross the blood-brain barrier, providing a more effective treatment option.
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Smart Images
Figure CN116265452B_ABST
Abstract
The present invention relates to nitrogen-containing heterocyclic compounds, processes for their preparation and their use. The nitrogen-containing heterocyclic compounds have the structure of general formula I, wherein the substituents are defined as described in the specification and claims. The nitrogen-containing heterocyclic compounds of the present invention are useful as therapeutic agents for the treatment of inflammatory diseases, ischemic diseases, degenerative diseases, tumor-related conditions and diseases.
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