Miniature single photon emission computed tomography as a dosimeter

By using a miniaturized nuclear imaging system with a solid-state detector and image processor, the problem of nonlinear sensitivity of gas cell detectors was solved, enabling high-precision radiopharmaceutical dosage calibration, simplifying the calibration process and reducing costs.

CN116324515BActive Publication Date: 2026-06-05SIEMENS MEDICAL SOLUTIONS USA INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SIEMENS MEDICAL SOLUTIONS USA INC
Filing Date
2020-09-10
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Existing gas cell detectors exhibit nonlinear sensitivity in radiopharmaceutical dosage calibration, resulting in errors exceeding 10%. Furthermore, the use and transportation of calibration sources are complex and expensive, and the universal dosage model is inaccurate.

Method used

A miniaturized nuclear imaging system is used to measure the activity of radiopharmaceuticals using a solid-state detector. The activity is reconstructed by scanning the syringe or vial to determine the injection dose, avoiding the use of calibration sources. The dose model is calibrated using a solid-state detector and an image processor.

Benefits of technology

It improves the accuracy of dosimetry, reduces the frequency of calibration source usage, achieves high-precision dosimetry calibration, simplifies the calibration process, and reduces costs.

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Abstract

For dosimetry, a miniaturized nuclear imaging system with a solid-state detector is used to determine the activity and / or injected dose of radiopharmaceuticals. By being sized to scan a syringe or vial, the solid-state detector can be used to determine the injected dose with higher accuracy than current dose calibrators and with less frequent use of calibration or normalization sources. The miniaturized nuclear imaging system reconstructs activity in the same way as a nuclear imaging system that scans patients, and therefore can be used to calibrate a dose model. A tissue mimicking phantom with a solid-state dosimeter measures the dose from a radiopharmaceutical that is used to calibrate the dose model.
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