A fast and long-acting calcium supplement preparation for dairy cows after delivery and preparation method thereof

Abstract

The present invention provides a fast and long-acting calcium supplement preparation for dairy cows after childbirth and a preparation method thereof. The fast and long-acting calcium supplement preparation for dairy cows after childbirth comprises a core material and a coating material coated on the periphery of the core material, wherein the core material is composed of two parts, segment A and segment B; segment A of the core material is composed of anhydrous calcium chloride and a carrier A that can be quickly dissolved and released in the rumen; segment B of the core material is composed of anhydrous calcium chloride and a carrier B that can be slowly released in the rumen; the coating material comprises coating material A and coating material B; coating material A is coated on the periphery of segment A of the core material, and coating material B is coated on the periphery of segment B of the core material. The present invention adopts a combination of fast-release segment A and slow-release segment B to obtain a composite coated calcium rod material, which can maintain a high blood calcium level for a long time (more than 24 hours) while rapidly improving the blood calcium of postpartum dairy cows; at the same time, the formula contains active 1,25-dihydroxyvitamin D3 that has passed the rumen, which stimulates the intestine to absorb more calcium and improves the absorption and utilization rate of calcium.

Description

Technical Field

[0001] The invention relates to the technical field of calcium preparation preparation, and in particular to a fast and long-acting calcium supplement preparation for dairy cows after delivery and a preparation method thereof. Background Art

[0002] Feed grade calcium chloride is a chemical substance composed of chlorine and calcium. Calcium chloride is often used in feed as an anionic salt additive. It has the functions of supplementing the calcium ions required by livestock and improving the acid-base balance of livestock body fluids. It can effectively increase the concentration of free calcium in the blood. It can be used to prevent postpartum hypocalcemia in dairy cows and reduce the occurrence of diseases such as postpartum paralysis, thereby helping to improve the reproductive performance of dairy cows.

[0003] As a feed additive, calcium chloride itself easily absorbs moisture, which can cause feed to clump and destroy its nutritional components. Calcium chloride releases heat when in contact with water and is somewhat irritating, which can cause oral and esophageal burns in livestock and poultry. Direct feeding can easily cause livestock and poultry to refuse to eat and has a strong irritating effect on the body tissues of livestock and poultry. In addition, calcium chloride is highly soluble in water and is quickly absorbed and utilized in the gastrointestinal tract of dairy cows, which can rapidly increase blood calcium concentration, but the maintenance time is generally not long. Therefore, it is necessary to perform slow-release treatment on it when using it in dairy cow feed.

[0004] Coated calcium chloride uses different types of coating materials to coat calcium chloride, which can prevent calcium chloride from absorbing moisture and agglomerating as much as possible, reduce the stimulation of calcium chloride to the body, and allow calcium chloride to be slowly released in the rumen of dairy cows, thereby maintaining the high blood calcium level of dairy cows for a long time. The invention patent with the authorization announcement number CN104585480B discloses a coated calcium chloride and a preparation method thereof. The coated calcium chloride includes the following raw materials in parts by weight: 5 to 20 parts of hydrogenated palm oil; 5 to 20 parts of hydrogenated castor oil; 4 to 30 parts of silicon dioxide; 1 to 20 parts of fatty acid calcium; and 60 to 85 parts of calcium chloride. The invention uses hydrogenated palm oil, hydrogenated castor oil, silicon dioxide and fatty acid calcium as the coating materials, and calcium chloride as the core material. Through multiple granulation and coating technology, coated calcium chloride that can be used as a feed additive is obtained. The coated calcium chloride not only makes up for the defect that the calcium chloride raw material is easy to absorb moisture, but also ensures that calcium chloride passes through the rumen safely and reaches the intestine smoothly, greatly improving the bioavailability of calcium chloride.

[0005] However, the coated calcium chloride is easily released too late or too short in the rumen of dairy cows, resulting in untimely calcium supplementation. High blood calcium levels can often only be maintained for about 6 hours, and dairy cows will still have low blood calcium on the fourth day after delivery. Therefore, it needs to be fed every once in a while, which is very cumbersome.

[0006] Therefore, it is very necessary to design a fast and long-acting calcium supplement for dairy cows. Summary of the invention

[0007] The invention provides a rapid and long-acting calcium supplement preparation for dairy cows after childbirth and a preparation method thereof. The rapid and long-acting calcium supplement preparation for dairy cows after childbirth can not only quickly improve the blood calcium level of the dairy cows after childbirth, but also maintain the high calcium level in the blood for a long time, thereby reducing the use frequency of coated calcium salt materials.

[0008] The specific technical solutions are as follows:

[0009] The invention provides a fast and long-acting calcium supplement preparation for dairy cows after delivery, comprising a core material and a coating material coated on the periphery of the core material, wherein the core material consists of two parts, segment A and segment B; segment A of the core material consists of anhydrous calcium chloride and a carrier A that can be quickly dissolved and released in a cow's stomach; segment B of the core material consists of anhydrous calcium chloride and a carrier B that can be slowly released in a cow's stomach; the coating material comprises coating material A and coating material B; coating material A is coated on the periphery of segment A of the core material, and coating material B is coated on the periphery of segment B of the core material.

[0010] Furthermore, the carrier A comprises calcium propionate, silicon dioxide, montmorillonite and sodium sulfate; the dosage ratio of the anhydrous calcium chloride to calcium propionate, silicon dioxide, montmorillonite and sodium sulfate is 50-70: 5-15: 5-15: 5-15: 10-20. The calcium propionate, silicon dioxide, montmorillonite and sodium sulfate used in the carrier A are all materials with high water solubility, which can quickly release calcium ions to meet the rapid absorption of calcium ions by postpartum dairy cows.

[0011] Different calcium salts have different solubility in water: calcium propionate is easily soluble in water; calcium sulfate is slightly soluble in water; calcium carbonate is almost insoluble in water, but can react with hydrochloric acid to form calcium chloride. Therefore, different calcium salts are released at different rates in the rumen, which will also affect the maintenance level of calcium ions in the blood after dairy cows eat. The combination of calcium salts with different solubility can prolong the maintenance time of blood calcium.

[0012] Furthermore, the carrier B includes calcium carbonate, 1,25-dihydroxyvitamin D 3 and calcium sulfate; the anhydrous calcium chloride and calcium carbonate, 1,25-dihydroxyvitamin D 3 The dosage ratio of calcium carbonate and 1,25-dihydroxyvitamin D used in carrier B is 20~30: 4~8: 10~20: 20~30. 3 Both calcium sulfate and calcium sulphate are materials with low water solubility and can slowly release calcium ions to meet the slow absorption of calcium by postpartum dairy cows.

[0013] Furthermore, the coating material A comprises the following raw materials in parts by weight: 30-50 parts of palm oil, 20-25 parts of hydroxypropyl methylcellulose and 25-30 parts of microcrystalline cellulose.

[0014] Furthermore, the coating material B includes coating material B 1 and coating material B 2 ; Wherein, the coating material B 1 The coating material B is composed of the following raw materials in parts by weight: 20-40 parts of stearic acid and 60-80 parts of sodium alginate; 2 The coating material B is composed of the following raw materials in parts by weight: 25-40 parts of sodium carboxymethyl cellulose and 60-75 parts of polyacrylic acid resin; 1 and coating material B 2 They are melted separately and then mixed.

[0015] Furthermore, the core material is formed by casting and pressing a fluid segment A and a fluid segment B; the fluid segment A is obtained by melting anhydrous calcium chloride and a carrier A and mixing them in water, and the fluid segment B is obtained by melting anhydrous calcium chloride and a carrier B and mixing them in water; the mass ratio of the fluid segment A to the fluid segment B is 1:1.

[0016] Furthermore, a layer of calcium stearate powder is sprayed on the periphery of the coating material.

[0017] The present invention also provides a method for preparing a fast and long-acting calcium supplement preparation for dairy cows after delivery, comprising the following steps:

[0018] (1) adding anhydrous calcium chloride and carrier A into water and heating and melting them to obtain a fluid segment A;

[0019] (2) adding anhydrous calcium chloride and carrier B into water and heating and melting them to obtain a fluid segment B;

[0020] (3) Casting and pressing the fluid section A and the fluid section B to obtain a core material;

[0021] (4) After the coating material A is heated and dissolved, the segment A of the core material is coated. After the film is solidified, the calcium chloride material coated with the segment A is obtained;

[0022] (5) After the coating material B is heated and dissolved, the segment B of the core material is coated. After the film is solidified, a composite coated calcium rod material in which both the segment A and the segment B are coated is obtained.

[0023] Furthermore, after the film in step (5) is cured, a layer of calcium stearate powder is sprayed onto the entire calcium chloride material.

[0024] Furthermore, in step (1) and step (2), the temperature of the heating and melting is 80-85°C; in step (4) and step (5), the temperature of the coating is 90-95°C.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] (1) The present invention adopts a combination of a fast-release A segment and a slow-release B segment to obtain a fast and long-acting calcium supplement preparation for postpartum dairy cows. While rapidly increasing the blood calcium level of postpartum dairy cows, it can maintain a high blood calcium level for a long time (more than 24 hours); at the same time, it contains active dihydroxyvitamin D3 that has passed the rumen, which stimulates the intestine to absorb more calcium, thereby improving the absorption and utilization rate of calcium.

[0027] (2) The coating material of the present invention is made of natural ingredients that are easily disintegrated to prevent rumen valve blockage and affect the normal physiological function of the rumen. DETAILED DESCRIPTION

[0028] The present invention will be further described below in conjunction with specific embodiments. The following are only specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto.

[0029] Example 1

[0030] This embodiment provides a fast and long-acting calcium supplement preparation for dairy cows after childbirth, which is composed of a core material and a coating material coated on the outer periphery of the core material;

[0031] The core material consists of two parts, section A and section B; section A of the core material consists of anhydrous calcium chloride and a carrier A that can be quickly dissolved and released in the cow's stomach; section B of the core material consists of anhydrous calcium chloride and a carrier B that can be slowly released in the cow's stomach; the coating material includes coating material A and coating material B; coating material A is coated on the periphery of section A of the core material, and coating material B is coated on the periphery of section B of the core material. The anhydrous calcium chloride is passed through a 20-mesh sieve.

[0032] Carrier A is composed of calcium propionate, silicon dioxide, montmorillonite and sodium sulfate; the dosage ratio of anhydrous calcium chloride to calcium propionate, silicon dioxide, montmorillonite and sodium sulfate is 60:10:10:10:15; Carrier B is composed of calcium carbonate, 1,25-dihydroxyvitamin D 3 and calcium sulfate; anhydrous calcium chloride and calcium carbonate, 1,25-dihydroxyvitamin D 3 The dosage ratio of calcium sulfate is 25:6:15:25. The coating material A is composed of the following raw materials in parts by weight: 40 parts of palm oil, 20 parts of hydroxypropyl methylcellulose and 30 parts of microcrystalline cellulose; the coating material B is composed of the coating material B 1 and coating material B 2 Composition; wherein the coating material B 1 The composition is composed of the following raw materials in parts by weight: 30 parts of stearic acid and 70 parts of sodium alginate; coating material B 2 The invention is composed of the following raw materials in parts by weight: 30 parts of sodium carboxymethyl cellulose and 70 parts of polyacrylic acid resin.

[0033] The preparation method of the above-mentioned rapid and long-acting calcium supplement preparation for dairy cows after delivery comprises the following specific steps:

[0034] (1) Add anhydrous calcium chloride and carrier A into water and heat to melt at a temperature of 80°C. Stir for 10 minutes to obtain a fluid segment A.

[0035] (2) Add anhydrous calcium chloride and carrier B into water and heat to melt at a temperature of 80°C. Stir for 10 minutes to obtain a fluid segment B.

[0036] (3) pouring and pressing the fluid segment A and the fluid segment B at a mass ratio of 1:1 to obtain a core material;

[0037] (4) After the coating material A is heated and dissolved, the section A of the core material is coated at a coating temperature of 90° C. After the film is solidified, a calcium chloride material coated with the section A is obtained;

[0038] (5) After the coating material B is heated and dissolved, the segment B of the core material is coated at a coating temperature of 90°C. After the film is solidified, a layer of calcium stearate powder is sprayed onto the entire calcium chloride material to obtain a fast and long-acting calcium supplement preparation for dairy cows after delivery in which both segments A and B are coated.

[0039] Example 2

[0040] This embodiment provides a fast and long-acting calcium supplement preparation for dairy cows after childbirth, which is composed of a core material and a coating material coated on the outer periphery of the core material;

[0041] The core material consists of two parts, section A and section B; section A of the core material consists of anhydrous calcium chloride and a carrier A that can be quickly dissolved and released in the cow's stomach; section B of the core material consists of anhydrous calcium chloride and a carrier B that can be slowly released in the cow's stomach; the coating material includes coating material A and coating material B; coating material A is coated on the outer periphery of section A of the core material, and coating material B is coated on the outer periphery of section B of the core material.

[0042] Carrier A is composed of calcium propionate, silicon dioxide, montmorillonite and sodium sulfate; the dosage ratio of anhydrous calcium chloride to calcium propionate, silicon dioxide, montmorillonite and sodium sulfate is 50:5:15:5:20; Carrier B is composed of calcium carbonate, 1,25-dihydroxyvitamin D 3 and calcium sulfate; anhydrous calcium chloride and calcium carbonate, 1,25-dihydroxyvitamin D 3 The dosage ratio of calcium sulfate is 25: 4: 20: 30. The coating material A is composed of the following raw materials in parts by weight: 50 parts of palm oil, 25 parts of hydroxypropyl methylcellulose and 25 parts of microcrystalline cellulose; the coating material B is composed of the coating material B 1 and coating material B 2 Composition; wherein the coating material B 1The composition is composed of the following raw materials in parts by weight: 40 parts of stearic acid and 60 parts of sodium alginate; coating material B 2 The invention is composed of the following raw materials in parts by weight: 40 parts of sodium carboxymethyl cellulose and 60 parts of polyacrylic acid resin.

[0043] The preparation method of the above-mentioned rapid and long-acting calcium supplement preparation for dairy cows after delivery comprises the following specific steps:

[0044] (1) Add anhydrous calcium chloride and carrier A into water and heat to melt at a temperature of 80°C. Stir for 10 minutes to obtain a fluid segment A.

[0045] (2) Add anhydrous calcium chloride and carrier B into water and heat to melt at a temperature of 80°C. Stir for 10 minutes to obtain a fluid segment B.

[0046] (3) pouring and pressing the fluid segment A and the fluid segment B at a mass ratio of 1:1 to obtain a core material;

[0047] (4) After the coating material A is heated and dissolved, the section A of the core material is coated at a coating temperature of 90° C. After the film is solidified, a calcium chloride material coated with the section A is obtained;

[0048] (5) After the coating material B is heated and dissolved, the segment B of the core material is coated at a coating temperature of 90°C. After the film is solidified, a layer of calcium stearate powder is sprayed onto the entire calcium chloride material to obtain a fast and long-acting calcium supplement preparation for dairy cows after delivery in which both segments A and B are coated.

[0049] Comparative Example 1

[0050] This embodiment provides a coated calcium rod, which is composed of a core material and a coating material coated on the outer periphery of the core material;

[0051] The core material is composed of anhydrous calcium chloride and a carrier A that can be quickly dissolved and released in the cow's stomach; the coating material is a membrane material A; and the coating material A is coated on the periphery of the core material. The anhydrous calcium chloride is passed through a 20-mesh sieve.

[0052] Carrier A is composed of calcium propionate, silicon dioxide, montmorillonite and sodium sulfate; the dosage ratio of anhydrous calcium chloride to calcium propionate, silicon dioxide, montmorillonite and sodium sulfate is 60:10:10:10:15; coating material A is composed of the following raw materials in parts by weight: 40 parts of palm oil, 20 parts of hydroxypropyl methylcellulose and 30 parts of microcrystalline cellulose.

[0053] The preparation method of the coated calcium rod comprises the following specific steps:

[0054] (1) adding anhydrous calcium chloride and carrier A into water and heating and melting them at a temperature of 80°C, stirring for 10 minutes to obtain a fluid core material, and then pouring and pressing to obtain a core material;

[0055] (2) After the coating material A is heated and dissolved, the A section of the core material is coated at a coating temperature of 90°C. After the film is solidified, a layer of calcium stearate powder is sprayed onto the entire calcium chloride material to obtain a coated calcium rod material;

[0056] Comparative Example 2

[0057] This embodiment provides a coated calcium rod, which is composed of a core material and a coating material coated on the outer periphery of the core material;

[0058] The core material is composed of anhydrous calcium chloride and a carrier B that can be slowly released in the cow's stomach; the coating material includes coating material B; and the coating material B is coated on the periphery of the core material segment B. The anhydrous calcium chloride is passed through a 20-mesh sieve.

[0059] Carrier B is composed of calcium carbonate, 1,25-dihydroxyvitamin D 3 and calcium sulfate; anhydrous calcium chloride and calcium carbonate, 1,25-dihydroxyvitamin D 3 The dosage ratio of 25:6:15:25 is 25:6:15:25. The coating material B is composed of the coating material B. 1 and coating material B 2 Composition; wherein the coating material B 1 The composition is composed of the following raw materials in parts by weight: 30 parts of stearic acid and 70 parts of sodium alginate; coating material B 2 The invention is composed of the following raw materials in parts by weight: 30 parts of sodium carboxymethyl cellulose and 70 parts of polyacrylic acid resin.

[0060] The preparation method of the coated calcium rod comprises the following specific steps:

[0061] (1) adding anhydrous calcium chloride and carrier B into water and heating and melting them at a temperature of 80°C, stirring for 10 minutes to obtain a fluid core material, and then pouring and pressing to obtain a core material;

[0062] (2) After the coating material B is heated and dissolved, the core material is coated at a coating temperature of 90°C. After the film is solidified, a layer of calcium stearate powder is sprayed onto the entire calcium chloride material to obtain a coated calcium rod material.

[0063] The materials obtained in Examples 1-2 and Comparative Examples 1-2 were fed to postpartum dairy cows, and the calcium content in the blood of the postpartum dairy cows at different time periods after feeding was measured.

[0064] The specific method is as follows: 20 multiparous cows are selected and randomly divided into two groups, namely, the embodiment group and the comparative example group, according to the parity, with 10 cows in each group; then the embodiment group is further divided into the embodiment 1 group and the embodiment 2 group, with 5 cows in each group; the comparative example group is further divided into the comparative example 1 group and the comparative example 2 group, with 5 cows in each group; the average parity is 3.8; samples are collected immediately after delivery, and then the materials prepared in the embodiments 1-2 and the comparative examples 1-2 are administered, and the initial blood calcium concentration of the cow is measured as T 0 (1.87 mmol / L); blood samples were collected at 0h, 1h, 6h, and 12h after feeding; the blood calcium concentration at the sampling time point after the first administration was divided by T 0 The blood sample is immediately centrifuged to separate the serum and measure the ionized calcium level in the serum.

[0065] The results are shown in Table 1.

[0066] Table 1 The increase in bovine blood calcium (unit: mmol / L) after administration of the materials of Examples 1-2 and Comparative Examples 1-2.

[0067]

[0068] The embodiments of the present invention disclose preferred embodiments, but are not limited thereto. A person skilled in the art can easily understand the spirit of the present invention based on the above embodiments and make different extensions and changes. However, as long as they do not deviate from the spirit of the present invention, they are all within the protection scope of the present invention.

Claims

1. A fast and long-acting calcium supplement preparation for dairy cows after childbirth, comprising a core material and a coating material coated on the periphery of the core material, characterized in that: The core material is composed of two parts, section A and section B; section A of the core material is composed of anhydrous calcium chloride and a carrier A that can be quickly dissolved and released in the bovine stomach; section B of the core material is composed of anhydrous calcium chloride and a carrier B that can be slowly released in the bovine stomach; the coating material includes coating material A and coating material B; coating material A is coated on the periphery of section A of the core material, and coating material B is coated on the periphery of section B of the core material; The carrier A comprises calcium propionate, silicon dioxide, montmorillonite and sodium sulfate; the dosage ratio of the anhydrous calcium chloride to calcium propionate, silicon dioxide, montmorillonite and sodium sulfate is 50-70: 5-15: 5-15: 5-15: 10-20; The carrier B comprises calcium carbonate, 1,25-dihydroxyvitamin D3 and calcium sulfate; the dosage ratio of the anhydrous calcium chloride to calcium carbonate, 1,25-dihydroxyvitamin D3 and calcium sulfate is: 20-30: 4-8: 10-20: 20-30; The coating material A comprises the following raw materials in parts by weight: 30-50 parts of palm oil, 20-25 parts of hydroxypropyl methylcellulose and 25-30 parts of microcrystalline cellulose; The coating material B includes coating material B1 and coating material B2; wherein, the coating material B1 is composed of the following raw materials in parts by weight: 20-40 parts of stearic acid and 60-80 parts of sodium alginate; the coating material B2 is composed of the following raw materials in parts by weight: 25-40 parts of sodium carboxymethyl cellulose and 60-75 parts of polyacrylic acid resin; the coating material B is obtained by melting the coating material B1 and the coating material B2 separately and then mixing them.

2. The rapid and long-acting calcium supplement preparation for dairy cows after delivery according to claim 1, characterized in that: The core material is formed by casting and pressing a fluid segment A and a fluid segment B; the fluid segment A is obtained by adding anhydrous calcium chloride and a carrier A into water and heating and melting them, and the fluid segment B is obtained by adding anhydrous calcium chloride and a carrier B into water and heating and melting them; the mass ratio of the fluid segment A to the fluid segment B is 1:

1.

3. The rapid and long-acting calcium supplement preparation for dairy cows after delivery according to claim 1, characterized in that: A layer of calcium stearate powder is also sprayed on the periphery of the coating material.

4. A method for preparing a fast and long-acting calcium supplement preparation for postpartum dairy cows according to any one of claims 1 to 2, characterized in that: The following steps are involved: (1) adding anhydrous calcium chloride and carrier A into water and heating and melting them to obtain a fluid segment A; (2) adding anhydrous calcium chloride and carrier B into water and heating and melting them to obtain a fluid segment B; (3) Casting and pressing the fluid section A and the fluid section B to obtain a core material; (4) After the coating material A is heated and dissolved, the segment A of the core material is coated. After the film is solidified, the calcium chloride material coated with the segment A is obtained; (5) After the coating material B is heated and dissolved, the segment B of the core material is coated. After the film is solidified, a composite coated calcium rod material in which both the segment A and the segment B are coated is obtained.

5. The method for preparing the fast and long-acting calcium supplement preparation for dairy cows after delivery according to claim 4, characterized in that: After the film in step (5) is solidified, a layer of calcium stearate powder is sprayed onto the periphery of the composite coated calcium rod material.

6. The method for preparing the fast and long-acting calcium supplement preparation for dairy cows after delivery according to claim 4, characterized in that: In step (1) and step (2), the temperature of the heating and melting is 80-85°C; in step (4) and step (5), the temperature of the coating is 90-95°C.

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