A Chinese medicine composition for preventing recurrence of intussusception in children

Abstract

The present invention relates to a Chinese medicine composition, which is prepared from the following Chinese medicines in parts by weight: 1-20 parts by weight of Corydalis yanhusuo, 1-20 parts by weight of Evodia rutaecarpa, 1-20 parts by weight of cloves, 1-20 parts by weight of Radish seeds, 1-20 parts by weight of Linderae rutaecarpa, 1-20 parts by weight of Chuanxiong, 1-20 parts by weight of Rhizoma Alismatis, 1-20 parts by weight of Stigma maydis and 1-20 parts by weight of Gleditsia sinensis. The Chinese medicine composition of the present invention can quickly and effectively enter the human body through Shenque acupoint application, achieve the effect of warming the interior to relieve spasm and relieve pain, for alleviating and improving the symptoms of intestinal adverse reactions caused by intussusception, preventing the recurrence of intussusception has a good effect, and is better in combination with hot compress with moxa salt bag. The Chinese medicine composition of the present invention has high safety in clinical use, and few adverse reactions occur.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for preventing recurrence of intussusception in children. Background Art

[0002] Intussusception refers to a condition in which a section of the intestine is inserted into the adjacent intestine, resulting in obstruction of intestinal permeability, which can lead to compression of the corresponding mesenteric blood vessels and obstruction of intestinal blood supply, resulting in intestinal wall congestion, edema, and necrosis. It is one of the most common acute abdominal diseases in infants and young children, and is more common in children under 2 years old, with the highest incidence at 4-10 months. Treatments for intussusception include air enema reduction, water pressure enema, and surgical intervention. Even after successful reduction, there is still a recurrence rate of 6%-12%. Recurrent intussusception (i.e., acute intussusception) recurs 2 or more times, with varying numbers of recurrences, and most of them occur in children under 2 years old. Repeated episodes of intussusception cause pain to the child and their parents, and also bring certain risks to the child, and increase the cost of treatment.

[0003] The etiology of intussusception in children is currently believed to be related to intestinal peristalsis disorders, enterovirus, mesenteric lymphadenopathy, etc. Early recurrence of intussusception in children after successful reduction by air enema may be related to the following factors: incomplete reduction during the first enema reduction; eating too early, the intussuscepted intestine itself has peristalsis disorders or spasms, and the early intussuscepted intestinal segment is still congested and edematous after reduction; ileocecal edema, edema of the intussuscepted ileocecal valve and cecum after intussusception reduction, and intestinal dysfunction, these factors work together to cause early intussusception recurrence. Common clinical symptoms of intussusception include mesenteric lymphadenopathy, intestinal obstruction, and abdominal pain.

[0004] Acupoint application of Chinese medicine is an external treatment method, which mainly expel pathogenic factors through stimulation of corresponding specific acupoints on the body surface and direct absorption of drugs, and at the same time stimulate and adjust the physiological functions of meridians and internal organs, adjust yin and yang, strengthen the body and expel pathogenic factors, so as to achieve therapeutic effects. Acupoint application belongs to the method of applying medicine, which is to mix the powdered Chinese medicine with some solvents (such as tea oil, vinegar, ginger, water, wine, etc.), apply it on specific acupoints, and use the direct and indirect effects of the medicine to exert pharmacological effects through meridians and internal organs. According to the theory of meridians and acupoints in traditional Chinese medicine, Shenque acupoint is often selected as the acupoint for application. This acupoint is the thinnest part of the abdominal wall, has no subcutaneous fat, is rich in blood vessels, and is easy to penetrate and absorb. After the medicine is applied to Shenque acupoint, the medicinal gas penetrates into the meridians through the acupoints and reaches the diseased area directly.

[0005] The moxa salt bag is applied to the acupuncture points on the surface of the human skin to perform hot moxibustion. With its warm effect, it penetrates the skin layer, promotes blood vessel dilation, reduces swelling and relieves pain, improves local blood circulation, and promotes the absorption and subsidence of inflammation. The effect of the moxa salt bag is similar to salt moxibustion. The heat generated is similar to infrared rays, has high penetrating power, and is absorbed by the human body, which can promote blood vessel dilation and improve local blood circulation.

[0006] Currently, there are few reports on traditional Chinese medicine formulas for the treatment of intussusception in children. Therefore, further exploring drugs from the field of traditional Chinese medicine for preventing the recurrence of intussusception in children and providing more abundant options for formulating clinical medication plans has become a technical problem that needs to be solved urgently. Summary of the invention

[0007] To solve the above technical problems, the present invention includes the following aspects:

[0008] The first aspect of the present invention is to provide a traditional Chinese medicine composition, which is prepared from the following traditional Chinese medicines: Corydalis yanhusuo, Evodia rutaecarpa, Clove, Radish Seed, Linderae scutellariae, Ligusticum chuanxiong, Alisma orientalis, Corn Silk and Gleditsia sinensis.

[0009] Preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 1-20 parts by weight of Corydalis yanhusuo, 1-20 parts by weight of Evodia rutaecarpa, 1-20 parts by weight of cloves, 1-20 parts by weight of radish seeds, 1-20 parts by weight of Linderae scutellariae, 1-20 parts by weight of Ligusticum chuanxiong, 1-20 parts by weight of Alisma orientalis, 1-20 parts by weight of corn silk and 1-20 parts by weight of Gleditsia sinensis.

[0010] More preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 5-15 parts by weight of Corydalis yanhusuo, 5-15 parts by weight of Evodia rutaecarpa, 5-15 parts by weight of cloves, 5-15 parts by weight of radish seeds, 5-15 parts by weight of Linderae scutellariae, 5-15 parts by weight of Ligusticum chuanxiong, 5-15 parts by weight of Alisma orientalis, 5-15 parts by weight of corn silk and 5-15 parts by weight of Gleditsia sinensis.

[0011] Most preferably, the Chinese medicine composition is prepared from the following Chinese medicines in parts by weight: 10 parts by weight of Corydalis yanhusuo, 10 parts by weight of Evodia rutaecarpa, 10 parts by weight of cloves, 10 parts by weight of radish seeds, 10 parts by weight of Linderae scutellariae, 10 parts by weight of Ligusticum chuanxiong, 10 parts by weight of Alisma orientalis, 10 parts by weight of corn silk and 10 parts by weight of Gleditsia sinensis.

[0012] The second aspect of the present invention provides a method for preparing the above-mentioned traditional Chinese medicine composition, which comprises the following steps: taking a prescribed amount of Corydalis yanhusuo, Evodia rutaecarpa, clove, radish seed, Linderae strychnos, Ligusticum chuanxiong, Alisma orientalis, corn silk and Gleditsia sinensis, respectively grinding them into fine powders, mixing them, passing through a 60-120 mesh sieve, adding an appropriate amount of distilled water, and adjusting them into a paste.

[0013] Preferably, in the preparation method, the fine powders are mixed and then passed through an 80-mesh sieve.

[0014] Preferably, in the preparation method, distilled water in an amount of 0.5 times the weight of the powder is added to the traditional Chinese medicine powder.

[0015] The third aspect of the present invention provides the use of the above-mentioned Chinese medicine composition in the preparation of a medicament for preventing or treating the recurrence of intussusception in children.

[0016] The fourth aspect of the present invention provides the use of the above-mentioned Chinese medicine composition in the preparation of a medicine for treating abdominal pain.

[0017] The fifth aspect of the present invention provides the use of the above-mentioned Chinese medicine composition in the preparation of a medicine for treating intestinal obstruction.

[0018] Preferably, the intestinal obstruction is incomplete intestinal obstruction.

[0019] Preferably, the Chinese medicine composition treats incomplete intestinal obstruction by reducing the level of interleukin in serum.

[0020] Preferably, the interleukin is IL-1β and / or IL-18.

[0021] More preferably, the Chinese medicine composition treats incomplete intestinal obstruction by simultaneously reducing the levels of interleukin IL-1β and IL-18 in serum.

[0022] A sixth aspect of the present invention provides use of the above-mentioned Chinese medicine composition in the preparation of a drug for down-regulating the secretion level of IL-1β and / or IL-18 in serum.

[0023] Preferably, the Chinese medicine composition is used in the preparation of a drug for simultaneously down-regulating the secretion levels of IL-1β and IL-18 in serum.

[0024] The common pharmacological effects of the Chinese medicinal raw materials selected in the present invention in this field are as follows:

[0025] Corydalis yanhusuo: warm in nature, pungent and bitter in taste, and enters the liver and spleen meridians. Corydalis yanhusuo can promote blood circulation, dissipate blood stasis, regulate qi and relieve pain. It is clinically used to treat pain caused by qi stagnation and blood stasis in various parts of the body, dysmenorrhea, amenorrhea, postpartum stasis, injuries from falls, and hernia pain. It has the effects of hypnosis, sedation, anticonvulsant, coronary artery dilation, anti-arrhythmia, and anti-ulcer.

[0026] Evodia rutaecarpa: hot in nature, pungent and bitter in taste, and enters the liver meridian, spleen meridian, stomach meridian, and kidney meridian. Evodia rutaecarpa can dispel cold and relieve pain, reduce adverse reactions and stop vomiting, and help yang and stop diarrhea. It is used to treat headaches in the Jueyin meridians, coldness in the Chong and Ren meridians, dysmenorrhea due to blood stasis, swelling and pain in the foot caused by cold and dampness, cold pain in the abdomen caused by cold stomach or coldness in the spleen and stomach, etc. It has pharmacological effects such as anti-gastric ulcer, lowering blood pressure, anti-thrombosis, insecticidal, and antibacterial.

[0027] Clove: Spicy, warm in nature, belongs to the stomach meridian, spleen meridian, and kidney meridian. Clove warms the middle and lowers adverse reactions, nourishes the kidney and helps yang, and is used to treat spleen and stomach deficiency and cold, hiccups and vomiting, poor appetite and vomiting, cold pain in the heart and abdomen, kidney deficiency and impotence, etc. It has anti-gastric ulcer, anti-diarrhea, choleretic, analgesic, anti-hypoxia, anti-coagulation, anti-mutation, antibacterial and insecticidal effects.

[0028] Radish seeds: spicy, sweet, neutral in nature, enter the lung meridian, spleen meridian, and stomach meridian. Radish seeds can relieve asthma, treat phlegm and digestion, eliminate bloating and relieve constipation, and stop gas pain. They are used for food stagnation, abdominal distension and pain, constipation, stagnation of stool, diarrhea, phlegm and asthma cough.

[0029] Linderae odoratum: warm in nature, pungent in taste, enters the lung meridian, spleen meridian, kidney meridian, and bladder meridian. Linderae odoratum can relieve depression, dispel cold and relieve pain. It is used to treat chest and abdominal distension and pain due to qi reversal, indigestion, nausea and vomiting, cold hernia, beriberi, frequent urination, etc. It has the effects of analgesia, hemostasis, liver protection, antibacterial, and anti-cancer.

[0030] Chuanxiong: warm in nature, pungent in taste, belongs to the liver meridian, gallbladder meridian, and pericardium meridian. Chuanxiong promotes blood circulation and qi, dispels wind and relieves pain. It is used for chest pain, chest and flank pain, swelling and pain due to falls, irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to urinary tract infections, headache, rheumatic pain, and has the effects of dilating blood vessels and lowering blood pressure.

[0031] Alisma: cold in nature, sweet and light in taste, and enters the kidney and bladder meridians. Alisma promotes urination and clears dampness and heat. It is used to treat urinary problems, edema, vomiting, diarrhea, phlegm, beriberi, gonorrhea, hematuria, etc. It has the effects of diuresis, regulating blood lipids, resisting kidney stone formation, lowering blood pressure, resisting fatty liver, anti-atherosclerosis, and anti-nephritis activity.

[0032] Corn silk: neutral in nature, sweet in taste. It enters the kidney meridian, stomach meridian, liver meridian, and gallbladder meridian. Corn silk has diuretic, detumescent, and antihypertensive effects. It is clinically used to treat nephritis edema, dysuria, damp-heat jaundice, cholecystitis, gallstones, and hypertension. It has diuretic, antihypertensive, choleretic, blood sugar-lowering, and hemostatic effects.

[0033] Gleditsia sinensis: warm in nature, pungent in taste, enters the liver and stomach meridians. Gleditsia sinensis can reduce swelling, expel toxins, discharge pus, and kill insects. It is used to treat carbuncle at the beginning or pus that does not break out, and externally treat scabies, leprosy.

[0034] Directions:

[0035] Clean the local skin with a warm water towel, apply the Chinese medicine of the present invention on the acupuncture points, and cover the local area with a special breathable adhesive patch. Apply for 2 hours, once a day, for 3 consecutive days. During the observation period, pay attention to the care of the pasted area to prevent allergies, local skin damage, etc.

[0036] The technical effects produced by the present invention are:

[0037] 1. The Chinese medicine composition of the present invention can enter the human body quickly and effectively through the application of Shenque acupoint, achieving the effect of warming the body, relieving spasms and relieving pain. It has a good effect on relieving and improving the symptoms of adverse intestinal reactions caused by intussusception and preventing the recurrence of intussusception. The effect is better when used with hot compress of moxa salt bag.

[0038] 2. The Chinese medicine composition of the present invention has high safety in clinical use, rarely causes adverse reactions, and has broad clinical application prospects. DETAILED DESCRIPTION

[0039] The present invention is further described below in conjunction with examples, but the embodiments of the present invention are not limited thereto. The experimental methods used in the following examples are conventional methods unless otherwise specified.

[0040] Example 1

[0041] Weigh 10 parts by weight of Corydalis yanhusuo, 10 parts by weight of Evodia rutaecarpa, 10 parts by weight of cloves, 10 parts by weight of radish seeds, 10 parts by weight of Linderae scutellariae, 10 parts by weight of Ligusticum chuanxiong, 10 parts by weight of Alisma orientalis, 10 parts by weight of corn silk and 10 parts by weight of Gleditsia sinensis, grind them into fine powder respectively, mix them, pass through an 80-mesh sieve, add 45 parts by weight of distilled water, and adjust them into a paste to obtain the Chinese medicine composition 1 of the present invention.

[0042] Example 2

[0043] Weigh 5 parts by weight of Corydalis yanhusuo, 15 parts by weight of Evodia rutaecarpa, 10 parts by weight of cloves, 10 parts by weight of radish seeds, 10 parts by weight of Linderae scutellariae, 10 parts by weight of Ligusticum chuanxiong, 10 parts by weight of Alisma orientalis, 10 parts by weight of corn silk and 10 parts by weight of Gleditsia sinensis, grind them into fine powder respectively, mix them, pass through an 80-mesh sieve, add 45 parts by weight of distilled water, and adjust them into a paste to obtain the Chinese medicine composition 2 of the present invention.

[0044] Example 3

[0045] Weigh 10 parts by weight of Corydalis yanhusuo, 10 parts by weight of Evodia rutaecarpa, 5 parts by weight of cloves, 15 parts by weight of radish seeds, 10 parts by weight of Linderae scutellariae, 10 parts by weight of Ligusticum chuanxiong, 10 parts by weight of Alisma orientalis, 10 parts by weight of corn silk and 10 parts by weight of Gleditsia sinensis, grind them into fine powder respectively, mix them, pass through an 80-mesh sieve, add 45 parts by weight of distilled water, and adjust them into a paste to obtain the Chinese medicine composition 3 of the present invention.

[0046] Example 4

[0047] Weigh 10 parts by weight of Corydalis yanhusuo, 10 parts by weight of Evodia rutaecarpa, 10 parts by weight of cloves, 10 parts by weight of radish seeds, 5 parts by weight of Linderae scutellariae, 15 parts by weight of Ligusticum chuanxiong, 10 parts by weight of Alisma orientalis, 10 parts by weight of corn silk and 10 parts by weight of Gleditsia sinensis, grind them into fine powder respectively, mix them, pass through an 80-mesh sieve, add 45 parts by weight of distilled water, and adjust them into a paste to obtain the Chinese medicine composition 4 of the present invention.

[0048] Example 5

[0049] Weigh 10 parts by weight of Corydalis yanhusuo, 10 parts by weight of Evodia rutaecarpa, 10 parts by weight of cloves, 10 parts by weight of radish seeds, 10 parts by weight of Linderae scutellariae, 10 parts by weight of Ligusticum chuanxiong, 5 parts by weight of Alisma orientalis, 15 parts by weight of corn silk and 10 parts by weight of Gleditsia sinensis, grind them into fine powder respectively, mix them, pass through an 80-mesh sieve, add 45 parts by weight of distilled water, and adjust them into a paste to obtain the Chinese medicine composition 5 of the present invention.

[0050] Comparative Example 1 (Evodia rutaecarpa is replaced by Citrus aurantium)

[0051] Weigh 10 parts by weight of Corydalis yanhusuo, 10 parts by weight of immature bitter orange, 10 parts by weight of clove, 10 parts by weight of radish seeds, 10 parts by weight of lindera stalks, 10 parts by weight of ligusticum chuanxiong, 10 parts by weight of oriental rhizome, 10 parts by weight of corn silk and 10 parts by weight of gleditsia spinosa, grind them into fine powders respectively, mix them, pass through an 80-mesh sieve, add 45 parts by weight of distilled water, and adjust them into a paste to obtain Chinese medicine comparative example 1.

[0052] Comparative Example 2 (Cloves replaced with White Peony Root)

[0053] Weigh 10 parts by weight of Corydalis yanhusuo, 10 parts by weight of evodia rutaecarpa, 10 parts by weight of white peony root, 10 parts by weight of radish seed, 10 parts by weight of lindera stalk, 10 parts by weight of ligusticum chuanxiong, 10 parts by weight of oriental rhizome, 10 parts by weight of corn silk and 10 parts by weight of gleditsia spinosa, grind them into fine powder respectively, mix them, pass through an 80-mesh sieve, add 45 parts by weight of distilled water, and adjust them into a paste to obtain Chinese medicine comparative example 2.

[0054] Test Example 1: Analgesic effect of the Chinese medicine composition of the present invention on a mouse pain model

[0055] 1. Test methods

[0056] 80 mice were randomly divided into a normal control group, a group of Chinese medicine compositions of the present invention 1-5 and a group of comparative examples 1-2, a total of 8 groups, 10 mice in each group. 1g of the Chinese medicine paste prepared in Examples 1-5 of the present invention and Comparative Examples 1-2 were taken respectively, flattened and placed in the middle of the acupoint sticker. Except for the normal control group, the other test groups applied the corresponding Chinese medicine stickers on the Shenque acupoint of the mice, once a day, for 2 hours each time, for 10 consecutive days. 1h after the last administration, acetic acid solution (0.7%, 10ml solution / kg body weight) was intraperitoneally injected into the mice of each test group. After 3min, the mice showed twisting behavioral reactions such as abdominal concavity, extension of the trunk and hind limbs, and stilts on the buttocks. The number of twists of the mice within 15min was observed and recorded.

[0057] 2. Test results

[0058] Table 1 shows the effects of the Chinese medicine paste of each test group of the present invention on the number of writhing times of the pain model of mice induced by acetic acid writhing method after 10 days of application.

[0059] Table 1 Effect of the Chinese medicine composition of the present invention on the number of writhing times in the mouse pain model

[0060] Experimental Group Number of twists in 15 minutes Normal control group 43.6±7.4 Example 1 Group 16.4±3.3 Example 2 Group 24.7±4.6 Example 3 Group 26.9±4.9 Example 4 Group 28.3±5.7 Example 5 Group 27.4±5.1 Comparative Example 1 33.6±6.2 Comparative Example 2 35.7±6.5

[0061] As can be seen from Table 1 above, compared with the normal control group and the comparative example 1-2 groups, the number of writhing times of the mice in the Example 1-5 groups of the present invention after injection of acetic acid was significantly reduced, and the differences between the above test groups were statistically significant, indicating that the Chinese medicine paste of the present invention has a significant effect on the treatment of abdominal pain.

[0062] Experimental Example 2: Effect of the Chinese medicine composition of the present invention on intestinal tissue of rats with intestinal obstruction model

[0063] 1. Test methods

[0064] Rats were fasted for 24h, anesthetized with 10% chloral hydrate (300g / kg), opened at 1 / 3 of the midline of the abdomen, exposed the ileocecal part, placed side by side with the central venous tube and the ileal intestinal tube, and ligated with silk thread around the intestinal tube and the central venous catheter at 1cm from the ileocecal part. Finally, the central venous catheter was extracted to cause incomplete intestinal obstruction, and the abdominal wall was sutured layer by layer. 80 rats after successful modeling were randomly divided into 8 groups, namely the model group, the Chinese medicine composition 1-5 group of the present invention and the comparative example 1-2 group, and 10 unoperated rats were taken as the normal control group. 1g of the Chinese medicine paste prepared by Examples 1-5 of the present invention and Comparative Example 1-2 was taken respectively, flattened and placed in the middle of the acupoint sticker. Except for the normal control group and the model group, the remaining test groups applied the corresponding Chinese medicine stickers on the Shenque acupoint of the mouse, once a day, for 2 hours each time, and continuously applied for 10 days.

[0065] 24 hours after the last administration, the rats in each experimental group were anesthetized and blood was collected from the femoral artery, and the rats were killed after centrifugation to obtain serum. The levels of interleukin-1β (IL-1β) and interleukin-18 (IL-18) in the serum of the rats in each experimental group were detected by ELISA.

[0066] 2. Test results

[0067] Table 2 shows the effects of the Chinese medicine paste of each test group on the interleukin level of rats with intestinal obstruction model after 10 days of application.

[0068] Table 2 Effect of the Chinese medicine composition of the present invention on the levels of IL-1β and IL-18 in the serum of model rats

[0069] Experimental Group IL-1β / (pg / mL) IL-18 / (pg / mL) Normal control group 8.02±0.47 9.65±0.42 Model Group 48.22±0.94 50.21±1.27 Example 1 Group 12.47±0.61 14.71±0.72 Example 2 Group 25.37±0.59 27.39±0.90 Example 3 Group 26.40±0.80 28.62±0.84 Example 4 Group 27.89±0.92 30.87±1.05 Example 5 Group 26.81±0.75 30.01±0.93 Comparative Example 1 35.95±1.21 40.25±1.19 Comparative Example 2 34.76±0.83 41.62±1.24

[0070] As can be seen from Table 2 above, compared with the normal control group, the IL-1β and IL-18 levels in the serum of the model group rats were significantly increased. Compared with the model group and the comparative example 1-2 group, the IL-1β and IL-18 secretion levels in the serum of the rats given the Chinese medicine composition of the embodiment 1-5 of the present invention were significantly reduced, and the differences between the above test groups were statistically significant. The above test results show that the Chinese medicine composition of the present invention can effectively improve the intestinal tissue pathological damage of rats with incomplete intestinal obstruction model, reduce inflammatory response, and effectively protect the intestinal mucosal immune barrier of rats with incomplete intestinal obstruction. Combined with the analgesic effect verified in Test Example 1, it is expected that the Chinese medicine composition of the present invention can be used clinically to prevent or treat the recurrence of intussusception in children.

[0071] Test Example 3: Clinical application cases of the Chinese medicine composition of the present invention

[0072] Case 1: Zhang, male, 16 months old, was admitted to the hospital for vomiting and paroxysmal abdominal pain for 6 hours. Ultrasound examination showed a 22mm×16mm "concentric circle sign" sonogram and a 45mm×16mm "sleeve" sonogram in the right upper abdomen, no intestinal peristalsis, and a clinical diagnosis of intussusception. Emergency "air enema repair under X-ray monitoring" treatment was performed. After treatment, the Chinese medicine composition prepared in Example 1 of the present invention (total weight of Chinese medicine components is 90g) was applied to the Shenque point for 2 hours, once a day, for 3 consecutive days. There was no recurrence of intussusception, and the patient was discharged from the hospital after 3 days of hospitalization.

[0073] Case 2: Zhang, male, 3 years and 5 months old, suffered from paroxysmal abdominal pain for more than half a day, accompanied by vomiting and diarrhea and was admitted to the hospital. Gastrointestinal ultrasound examination showed a 30mm×26mm "concentric circle sign" sonogram and a 36mm×24mm "sleeve" sonogram in the right upper abdomen, no intestinal peristalsis, and a clinical diagnosis of intussusception. Emergency "air enema repair under X-ray monitoring" treatment was performed. After treatment, the Chinese medicine composition prepared in Example 1 of the present invention (total weight of Chinese medicine components is 90g) was applied to the Shenque point for 2 hours, once a day, for 3 consecutive days. There was no recurrence of intussusception, and the patient was discharged from the hospital after 3 days of hospitalization.

[0074] Case 3: Hu Moumou. Male, 1 year and 9 months old, was admitted to the hospital for 4 hours of paroxysmal abdominal pain. Gastrointestinal ultrasound examination showed a 38mm×32mm "concentric circle sign" sonogram and a 54mm×35mm "sleeve" sonogram in the right upper abdomen, no intestinal peristalsis, and a clinical diagnosis of intussusception. Emergency "air enema repair under X-ray monitoring" treatment was performed. After treatment, the Chinese medicine composition prepared in Example 1 of the present invention (total weight of Chinese medicine components is 90g) was applied to the Shenque point for 2 hours, once a day, for 3 consecutive days of treatment. There was no recurrence of intussusception, and the patient was discharged from the hospital after 3 days of hospitalization.

[0075] Case 4: Miao Moumou, female, 1 year and 1 month old, was hospitalized for 2 days of abdominal pain accompanied by vomiting and diarrhea. Gastrointestinal ultrasound examination showed a 35mm×28mm "concentric circle sign" sonogram and a 57mm×27mm "sleeve" sonogram in the right upper abdomen, no intestinal peristalsis, 50mm×25mm without echo in the right lower abdomen, and 8mm×5mm without echo in the left lower abdomen. The clinical diagnosis was intussusception. Emergency "air enema repair under X-ray monitoring" treatment was performed. After treatment, the Chinese medicine composition prepared in Example 1 of the present invention (the total weight of the Chinese medicine components is 90g) was applied to the Shenque point for 2 hours, once a day, and treated for 3 consecutive days. The intussusception did not recur, and the child had no abdominal pain and other discomforts. He was discharged from the hospital after 3 days of hospitalization.

[0076] Case 5: Hu Moumou, female, 1 year and 8 months old, had paroxysmal abdominal pain and discomfort for 6 hours. Gastrointestinal ultrasound examination showed a 38mm×32mm "concentric circle sign" sonogram and a 54mm×35mm "sleeve" sonogram in the right upper abdomen, no intestinal peristalsis, and a clinical diagnosis of intussusception. Emergency "air enema repair under X-ray monitoring" treatment was performed. After treatment, the Chinese medicine composition prepared in Example 1 of the present invention (the total weight of the Chinese medicine components is 90g) was applied to the Shenque point for 2 hours, once a day, for 3 consecutive days of treatment. There was no recurrence of intussusception, the child had no abdominal pain, and was discharged from the hospital after 3 days of hospitalization.

[0077] Although specific embodiments of the present invention have been described, it will be appreciated by those skilled in the art that various changes and modifications may be made to the present invention without departing from the scope or spirit of the present invention. Therefore, the present invention is intended to cover all such changes and modifications that fall within the scope of the appended claims and their equivalents.

Claims

1. A Chinese medicine composition, characterized in that: The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 5-15 parts by weight of Corydalis yanhusuo, 5-15 parts by weight of Evodia rutaecarpa, 5-15 parts by weight of cloves, 5-15 parts by weight of radish seeds, 5-15 parts by weight of Linderae scutellariae, 5-15 parts by weight of Ligusticum chuanxiong, 5-15 parts by weight of Alisma orientalis, 5-15 parts by weight of corn stigma and 5-15 parts by weight of Gleditsia sinensis.

2. The Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 10 parts by weight of Corydalis yanhusuo, 10 parts by weight of Evodia rutaecarpa, 10 parts by weight of Clove, 10 parts by weight of Radish Seed, 10 parts by weight of Linderae scutellariae, 10 parts by weight of Ligusticum chuanxiong, 10 parts by weight of Alisma orientalis, 10 parts by weight of Corn Silk and 10 parts by weight of Gleditsia sinensis.

3. The method for preparing the Chinese medicine composition according to claim 1 or 2, characterized in that: The preparation method comprises the following steps: taking prescribed amounts of Corydalis yanhusuo, Evodia rutaecarpa, Clove, Radish Seed, Linderae umbellatae, Ligusticum chuanxiong, Alisma orientalis, Corn Silk and Gleditsia sinensis, respectively grinding them into fine powders, mixing them, passing through a 60-120 mesh sieve, adding an appropriate amount of distilled water and adjusting them into a paste.

4. The preparation method according to claim 3, characterized in that: The fine powders were mixed and passed through an 80-mesh sieve.

5. The preparation method according to claim 3, characterized in that: Add 0.5 times the weight of distilled water to the Chinese medicine powder.

6. Use of the Chinese medicine composition according to claim 1 or 2 in the preparation of a medicament for preventing or treating recurrence of intussusception in children.

7. Use of the Chinese medicine composition according to claim 1 or 2 in the preparation of a medicine for treating abdominal pain.

8. Use of the Chinese medicine composition according to claim 1 or 2 in the preparation of a medicament for treating intestinal obstruction.