Liquid injection device for living organisms

Abstract

The present application provides a biological liquid injection tool that can make a liquid more fine and spray it into a body cavity. The nozzle of the biological liquid injection tool of the present application has a tubular liquid discharge portion (discharge tube (13)) provided at the tip (head (12)) of the nozzle and discharging a liquid in the internal space, and a gas discharge portion (12f) located near the discharge tube (13) and spraying gas to the liquid discharged from the discharge tube (13) to spray the liquid in a mist. On the discharge tube (13), an inflow opening portion (slit (13b)) is formed on the side of the gas discharge portion (12f), and an outflow opening portion (slit (13c)) is formed on the side opposite to the side of the gas discharge portion (12f). The gas discharge portion (12f) sprays a gas supply gas in a direction intersecting the discharge direction of the liquid discharged from the discharge tube (13). The slits (13b, 13c) are formed on the extension line of the spray direction of the gas supply gas (G) sprayed by the gas discharge portion (12f).

Description

Technical Field

[0001] This invention relates to a biological medication injection device for spraying medication onto the affected area of ​​an organism. Background Technology

[0002] In treatments or procedures within a living organism, the following steps are generally performed: a cannula is passed through an opening formed in the abdomen or similar opening, and a nozzle is then passed through the inside of the cannula to introduce a drug solution into the body cavity.

[0003] Moreover, Patent Document 1 discloses a technology that enables the spraying of liquid medicine over a wide area even when the nozzle configuration is limited by the cannula needle.

[0004] The biological drug injection device described in Patent Document 1 (described in this document as a biological tissue adhesive coating device) is capable of spraying various drug solutions and the gas used to mix these drug solutions at an angle relative to the axis of the nozzle. Thus, if the structure sprays the drug solution at an angle relative to the axis of the nozzle, the drug solution can be sprayed over a wide area by rotating the nozzle around the axis.

[0005] Existing technical documents

[0006] Patent documents

[0007] Patent Document 1: Japanese Patent Application Publication No. 2013-74988 Summary of the Invention

[0008] The technical problem to be solved by the invention

[0009] In the biological drug injection device disclosed in Patent Document 1, the distal ends of both the gas ejection path and the drug flow path are formed at an angle relative to the axial direction of the nozzle, thereby spraying the drug and gas.

[0010] Furthermore, in this biological drug injection device, when gas is supplied to the drug solution at a high pressure (e.g., 0.1 MPa), it is necessary to prevent the position of sheets such as tissue adhesive sheets, which are the targets of spraying, from shifting due to the air pressure.

[0011] When the gas supply pressure is reduced (e.g., to 0.07 MPa) to prevent positional deviation, there is room for improvement in using gas to refine the particle size of the liquid medicine, making it easier to mix multiple liquid medicines and effectively coat the liquid medicine to the downwind side.

[0012] The present invention was made in view of the above-mentioned problems, and its object is to provide a biological drug injection device that can make the drug solution more finely granulated and sprayed into the body cavity.

[0013] means for solving technical problems

[0014] The biological drug injection device of the present invention is characterized by comprising: a main body; and a nozzle extending from the main body, the nozzle comprising: a tubular drug dispensing portion disposed at the front end of the nozzle and dispensing drug liquid located in the internal space; and a gas dispensing portion located near the drug dispensing portion, wherein the drug liquid is sprayed in a mist form by spraying gas onto the drug liquid dispensed from the drug dispensing portion, an inflow opening is formed on the peripheral wall of the drug dispensing portion on the side of the gas dispensing portion, and an outflow opening is formed on the side opposite to the side of the gas dispensing portion, the gas dispensing portion sprays gas in a direction intersecting the dispensing direction of the drug liquid dispensed from the drug dispensing portion, and the inflow opening and the outflow opening are formed on the extension line of the spraying direction of the gas sprayed through the gas dispensing portion.

[0015] The effects of the invention

[0016] According to the present invention, a biological drug injection device is provided that can atomize the drug solution into finer particles and spray it into the body cavity. Attached Figure Description

[0017] Figure 1 This is a perspective view showing the biological tissue adhesive application tool and its peripheral equipment involved in this embodiment.

[0018] Figure 2 It indicates that it is located at Figure 1 An enlarged 3D view of the nozzle head at the front end.

[0019] Figure 3 It is a cross-sectional view of the front end of the nozzle, showing a vertical section through the central axis of the discharge pipe and the gas ejection section.

[0020] Figure 4 This is the main view of the header.

[0021] Figure 5 This is a graph showing the wind force of the gas at each air pressure for the delivery gas in the comparative examples and embodiments.

[0022] Figure 6 This is a graph showing the particle size of the sprayed liquids in the comparative examples and embodiments.

[0023] Figure 7 This is a diagram showing the head involved in the modified example, and it is a cross-sectional view of the front end of the nozzle through a vertical section of the central axis of the discharge pipe and the gas ejection section. Detailed Implementation

[0024] Hereinafter, embodiments of the biological drug injection device of the present invention will be described with reference to the accompanying drawings.

[0025] Furthermore, the embodiments described below are merely examples to facilitate understanding of the present invention and do not limit the present invention. That is, regarding the shape, size, arrangement, etc. of the components described below, changes and modifications can naturally be made without departing from the spirit of the present invention, and equivalents thereof are naturally included in the present invention.

[0026] Furthermore, in all the accompanying drawings, the same reference numerals are used to label the same constituent elements, and repeated descriptions are omitted where appropriate. Also, the side of the biological drug injection device from which the drug is dispensed (the side furthest from the surgeon) is referred to as the anterior or distal side, and the opposite side as the posterior or proximal side, also referred to as the anterior side and basal side, respectively.

[0027] <Summary of the Invention>

[0028] First, the main reference Figures 1 to 3 The general outline of the present invention will be described.

[0029] Figure 1 This is a perspective view showing the biological tissue adhesive application tool 1 and its peripheral equipment involved in this embodiment. Figure 2 It indicates that it is located at Figure 1 An enlarged perspective view of the head 12 at the front end of nozzle X. Figure 3 It is a cross-sectional view of the front end of the nozzle X, which is a vertical section of the central axis of the discharge pipe 13 and the gas ejection section 12f.

[0030] like Figure 1 As shown, the biological drug injection device (biological tissue adhesive coating device 1) has a main body 2 and a nozzle X extending from the main body 2.

[0031] The nozzle X includes: a tubular liquid discharge section (discharge pipe 13) disposed at the front end (head 12) of the nozzle X and discharging liquid medicine 10 located in the internal space; and a gas discharge section 12f located near the discharge pipe 13, which sprays gas (gas delivery gas G) onto the liquid medicine 10 discharged from the discharge pipe 13 to make the liquid medicine 10 spray in a mist.

[0032] On the peripheral wall 13a of the discharge pipe 13, an inflow opening (slit 13b) is formed on the side of the gas discharge portion 12f, and an outflow opening (slit 13c) is formed on the side opposite to the gas discharge portion 12f.

[0033] The gas ejection section 12f ejects gas G in a direction that intersects with the ejection direction of the liquid medicine 10 ejected from the ejection pipe 13.

[0034] The slits 13b and 13c are characterized in that they are formed on the extension line of the injection direction of the gas G injected through the gas ejection section 12f.

[0035] In the discharge pipe 13 of this embodiment, the inflow opening for the delivery gas G to flow in is a slit 13b and the outflow opening for the delivery gas G to flow out is a slit 13c. However, the present invention is not limited to this structure.

[0036] That is, the "inflow opening" and "outflow opening" in the discharge tube 13 only need to be able to allow the gas G to pass into the liquid discharge section (discharge tube 13) and split the liquid 10. Therefore, the "inflow opening" and "outflow opening" are not limited to being formed as long slits 13b and 13c, but can also be round holes or grid-shaped holes.

[0037] Furthermore, they can be provided in multiples, or they can be formed by joining mesh components to the front end of the liquid dispensing part (dispensing tube 13).

[0038] In addition, the following describes the following structure: the discharge pipe 13 extends parallel to the extension direction of the nozzle X, and the gas ejection part 12f extends in a direction intersecting the extension direction of the discharge pipe 13 to spray the gas G onto the liquid medicine 10 discharged from the discharge pipe 13.

[0039] However, it is not limited to this structure, and it can also be the opposite structure (i.e., the gas ejection section 12f extends parallel to the extension direction of the nozzle X, and the discharge pipe 13 extends in a direction that intersects the extension direction of the gas ejection section 12f).

[0040] According to the above structure, by using the structure of spraying the aerosol gas G through the inflow opening (slit 13b) and the outflow opening (slit 13c) formed in the liquid discharge section (discharge pipe 13), the liquid 10 supplied to the discharge pipe 13 can be sprayed in a finer particle.

[0041] <About the overall structure>

[0042] Main Reference Figure 1 and Figure 2 The overall structure of the biological tissue adhesive coating tool 1 and its peripheral equipment, which is the biological drug injection tool of the present invention, will be described.

[0043] The biological drug injection device (biological tissue adhesive coating device 1) according to the present invention is a device for injecting (coating / spraying) a drug solution into the body. The drug solution 10 (see reference) is the target of injection in the biological drug injection device according to the present invention. Figure 3 The agent can be one type, or it can be two or more types, such as the liquid 10 sprayed by the biological tissue adhesive application tool 1 according to this embodiment. The biological tissue adhesive application tool 1 has the function of spraying / mixing the various liquids 10 described later at the dispensing point and applying them as an adhesive to organs and the like in a living organism.

[0044] The biological tissue adhesive application tool 1 includes a main body 2 having an internal space 2s and a nozzle X communicating with the space 2s of the main body 2 and extending to the distal side.

[0045] The nozzle X has an extension 11 that communicates with the space 2s inside the main body 2 and extends from the front end of the main body 2, and a head 12, which will be described later, is mounted on the front end of the extension 11.

[0046] At the proximal end of the main body 2, a syringe mounting port 2d is provided, protruding towards the proximal end. Liquid medicine 10 is supplied from the syringe 17 and plunger 7 mounted at the syringe mounting port 2d to the dispensing tube 13 via the main body 2.

[0047] Furthermore, the supplied gas G (reference) Figure 3 The gas is filled into the main body 2 via the gas injection section 2g. The gas G filled into the main body 2 is supplied to the gas ejection section 12f.

[0048] The main body 2 is provided with a gas supply gas G for injecting gas into its internal space within 2 seconds (reference). Figure 3 The gas injection section 2g is formed at the protrusion of the portion that protrudes upward and backward (proximal side) on the main body 2.

[0049] Regarding the gas ejection section 12f, its details will be described later. It ejects the gas G from the gas injection section 2g into the space 2s inside the main body section 2 and mixes the liquid medicine 10 ejected from the ejection pipe 13 with a mist spray.

[0050] A gas delivery hose 31 is connected to the biological tissue adhesive application tool 1, which introduces gas G for spraying the drug solution 10 into the main body 2. The gas delivery hose 31 is connected to a regulator 30 that adjusts the amount of gas G, and is connected to the main body 2 via an air filter 9.

[0051] Specifically, the air supply hose 31 is connected to the regulator 30 by a connector 31a located at the base end, and to the connection port 9a of the air filter 9 by a connector 31b located at the front end. Dust and bacteria are removed from the air supply gas G supplied from the regulator 30 by passing it through the air filter 9.

[0052] The gas G is introduced from the regulator 30 through the gas supply hose 31, air filter 9, and gas injection section 2g into the space 2s inside the main body 2.

[0053] Furthermore, the main body 2 is equipped with two plungers 7 and syringes 17 for introducing different liquid medications into the interior of the main body 2 (more specifically, a flexible tube, not shown, located inside the main body 2 and connected to the dispensing tube 13) via the syringe mounting port 2d.

[0054] Specifically, at the two ends of the rear surface of the main body 2, two portions protrude rearward, and syringe mounting ports 2d, serving as drug injection portions, are formed at the rear ends of these portions. Syringes 17 are connected to each of the two syringe mounting ports 2d. Drug solution 10, filled in each of the two syringes 17, is forced into the syringes 17 by the plunger 7 and supplied to the dispensing tube 13 via the syringe mounting ports 2d and a tubing (not shown) within the main body 2.

[0055] Furthermore, the biological tissue adhesive application tool 1 includes a plunger retainer 8 for simultaneously pressing the two plungers 7 against the syringe 17. The plunger retainer 8 is formed to a size that allows it to abut against the base end sides of the two plungers 7.

[0056] The extension 11 of the nozzle X is used to ensure the length for fitting the head 12, which is mounted at the front end of the extension 11, into the body cavity. For example, in the case of a biological tissue adhesive application tool 1 used during thoracoscopic surgery.

[0057] For example, when performing EAS (endoscope-assisted surgery) surgery by inserting a cannula (not shown), medication 10 needs to be applied to the insertion point of the cannula. In this case, since the nozzle X has an extension 11, the nozzle X can be lengthened in the axial direction, thereby extending the reach of the head 12, the area where the medication 10 is sprayed, according to the application position of the medication 10.

[0058] <About the structures around the head>

[0059] Next, besides reference Figures 1 to 3 In addition, it mainly refers to Figure 4 The head 12 and the structures surrounding the head 12 are described. Figure 4 This is the main view of head 12.

[0060] like Figure 2 and Figure 3 As shown, the head 12 involved in this embodiment includes a head body 12b, two tubular discharge tubes 13, and two gas ejection sections 12f located near the discharge tubes 13 and spraying gas G onto the liquid medicine 10 discharged from the discharge tubes 13.

[0061] A fitting portion 12h is formed at the rear end of the head body 12b to fit with the front end of the extension portion 11. The fitting portion 12h has an outer surface with a diameter smaller than other parts of the head body 12b, and this outer surface fits against the inner surface of the extension portion 11.

[0062] [Dispensing tube]

[0063] The discharge tube 13 extends distally from the head body 12b. The liquid medicine 10 is sprayed in a mist form using the aerated gas G ejected from the gas ejection section 12f.

[0064] The base of the dispensing tube 13 is connected to the front end of a liquid flow tube (not shown), which communicates with the syringe mounting port 2d. Two liquids, intended for mixing, are dispensed from the two dispensing tubes 13.

[0065] In this embodiment, one of the dispensing tubes 13 dispenses a liquid containing fibrinogen or the like. The other of the dispensing tubes 13 allows a liquid containing thrombin or the like to flow through, which acts as a binder against fibrinogen or the like.

[0066] On the liquid dispensing part (dispensing tube 13), a circumferentially formed portion 13d is formed closer to the end side (the base end side as the head body 12b side) than the inflow opening (slit 13b) and the outflow opening (slit 13c).

[0067] That is, in the discharge tube 13 of this embodiment, there is a portion (a portion with a circular cross-section) that does not intersect with the slits 13b and 13c in the circumferential direction.

[0068] According to the above structure, by forming the surrounding part 13d, the rigidity of the liquid dispensing part (dispensing tube 13) can be suppressed due to the inflow into the opening part (slit 13b) and the outflow into the opening part (slit 13c).

[0069] like Figure 4 As shown, the opening width W2 on the outer periphery of the inflow opening (slit 13b) is wider than the opening width W1 on the inner periphery.

[0070] Here, "width" refers to the width from the axial direction ( Figure 4 The length of the direction orthogonal to the jet direction of the gas ejection section 12f when observing the head 12 of nozzle X (as shown). The meanings of the outer and inner circumferences of the inflow opening are the same as those of the outer and inner circumferences of the discharge pipe 13.

[0071] According to the above structure, since the opening width W2 on the outer periphery of the inflow opening (slit 13b) is wider than the opening width W1 on the inner periphery, the gas supply G can be drawn into the discharge pipe 13 over a wide range, and the flow rate of the gas supply G drawn into the discharge pipe 13 is accelerated. Therefore, the liquid medicine 10 supplied to the inside of the discharge pipe 13 is easily abraded into fine particles by the shearing effect of the gas supply G.

[0072] like Figure 4 As shown, the opening width W2 on the outer periphery of the inflow opening (slit 13b) is wider than the flow path diameter D of the gas ejection section 12f.

[0073] If the delivery gas G injected from the gas ejection section 12f is discharged from the gas ejection section 12f, the spray area of ​​the delivery gas G widens as it moves away from the gas ejection section 12f.

[0074] According to the above structure, the opening width W2 of the slit 13b is wider than the flow path diameter D of the gas ejection section 12f, so that the gas G that is discharged from the gas ejection section 12f and diffuses can be widely taken in through the slit 13b.

[0075] Conversely, the flow path diameter D of the gas ejection section 12f is formed to be narrower than the opening width W2 of the outer periphery of the slit 13b. Thus, by narrowing the flow path diameter D, the flow path area of ​​the gas ejection section 12f becomes smaller. Through pressure loss caused by contact with the wall surface of the gas ejection section 12f, the air pressure of the supplied gas G from the gas ejection section 12f can be reduced, and the air velocity can be increased. Therefore, deviation in the spray area of ​​the liquid drug 10 can be suppressed.

[0076] The opening width W1 of the inflow opening (slit 13b) on the inner circumferential side is narrower than the flow path diameter D of the gas ejection section 12f.

[0077] According to the above structure, the flow rate of the gas delivery gas G is increased to draw the gas delivery gas G into the interior of the discharge tube 13, and the liquid medicine 10 supplied to the interior of the discharge tube 13 is sheared to make it easier to granulate.

[0078] The opening width W4 on the outer periphery of the outflow opening (slit 13c) is wider than the opening width W3 on the inner periphery.

[0079] By spraying the liquid medicine 10 flowing into the discharge tube 13 to the outside through the outflow opening (slit 13c) with the outer peripheral opening width W4 being wider than the inner peripheral opening width W3, fine-grained liquid medicine can be sprayed out.

[0080] Conversely, the opening width W3 on the inner circumference of slit 13c is narrower than the opening width W4 on the outer circumference of slit 13b. This configuration prevents the liquid medicine 10 from dripping downwards through the opening width W3 before atomization.

[0081] At least one of the inflow opening (slit 13b) and the outflow opening (slit 13c) is formed as a slit, and is formed to be longer in the extension direction of the liquid discharge portion (discharge tube 13).

[0082] Furthermore, in this embodiment, as described above, both the inflow opening and the outflow opening are formed into a slit shape. However, one of them may also be a round or rectangular hole, rather than a slit shape.

[0083] As described above, if at least one of the inflow opening and the outflow opening is a slit 13b or 13c that extends parallel to the extension direction of the discharge pipe 13, which is the flow path direction of the liquid medicine 10, it is preferable that even if the liquid medicine 10 has a high flow rate, the liquid medicine 10 can be divided within a wide range in the flow path direction by passing the gas G through the slit 13b or slit 13c.

[0084] like Figure 2 As shown, when the outer surface of the discharge tube 13 is viewed radially, the bottom of the edge surface of the proximal side of the slits 13b and 13c is formed in an arc shape. That is, the slits 13b and 13c have arc-shaped edges.

[0085] By forming the slit 13b in this way, the gas G ejected from the gas ejection section 12f can be easily received into the interior of the discharge pipe 13.

[0086] Furthermore, the bottoms of slits 13b and 13c are formed to be wide open toward the outer periphery. By configuring slits 13b and 13c in this way, the gas G can flow in more easily even in the axial direction of the discharge pipe 13, and expand more easily when it flows out.

[0087] like Figure 3 As shown, the liquid dispensing section (dispensing tube 13) protrudes further to the distal end than the gas dispensing section 12f.

[0088] The ejection opening 12m of the gas ejection section 12f is formed at an angle relative to a virtual plane orthogonal to the extension direction of the ejection pipe 13, protruding toward the front end of the ejection pipe 13 as it moves radially away from the ejection pipe 13.

[0089] In other words, the surface with the ejection opening 12m (in this embodiment, an orthogonal surface 12n formed in a manner orthogonal to the ejection direction of the gas G) is formed at an inclination relative to a virtual plane orthogonal to the extension direction of the ejection pipe 13, protruding toward the front end of the ejection pipe 13 as it moves radially away from the ejection pipe 13.

[0090] Thus, by forming the orthogonal plane 12n at an inclination relative to the aforementioned virtual plane, the upper end of the ejection opening 12m is close to the ejection tube 13 at a length equal to the diameter of the front opening of the ejection tube 13.

[0091] According to the above structure, the gas ejection opening 12m of the gas ejection section 12f protrudes towards the front end of the ejection pipe 13, making it easy to maintain a relatively fast flow rate of the delivered gas G until it reaches the ejection pipe 13.

[0092] Furthermore, in this embodiment, the dispensing tube 13 and the liquid flow tube (not shown) within the main body 2 are separate components, but the present invention is not limited to this structure and can also be formed integrally.

[0093] Furthermore, as long as the liquid medicine 10 can be sprayed in a direction that intersects the axial direction of the nozzle X, the extension direction of the discharge pipe 13, which is the discharge direction of the liquid medicine 10, does not necessarily have to be parallel to the axial direction of the nozzle X.

[0094] [Gas ejection section]

[0095] The gas ejection section 12f is a part that ejects gas G from the gas injection section 2g into the space 2s inside the main body section 2 at the front end of the head 12.

[0096] In this embodiment, the gas ejection portion 12f consists of two through holes extending toward the outlet of the liquid medicine 10 ejected through each of the two ejection pipes 13. Specifically, the gas ejection portion 12f extends obliquely downward toward the distal side in a manner that intersects the axial direction of the nozzle X (and the ejection pipe 13).

[0097] Since the discharge tube 13 and the gas ejection section 12f each extend in this orientation, by rotating the biological tissue adhesive application tool 1 around the axis of the nozzle X, the ejection direction of the gas G can be oriented, thereby adjusting the spray direction of the liquid medicine 10. Hereinafter, the ejection direction refers to the vector pointing towards the distal end with the gas ejection section 12f as a reference.

[0098] Alternatively, if it is not necessary to configure the structure so that the spray direction of the liquid medicine 10 is adjusted by rotating the biological tissue adhesive application tool 1, then as described above, it can be configured such that the gas ejection part 12f extends parallel to the extension direction of the nozzle X, and the discharge pipe 13 extends in a direction that intersects the extension direction of the gas ejection part 12f.

[0099] like Figure 3 As shown, the ejection opening 12m of the gas ejection section 12f is formed on a surface (orthogonal surface 12n) that is orthogonal to the ejection direction of the gas delivery gas G.

[0100] According to the above structure, it is easy to make the gas supply gas G be ejected from the ejection opening 12m at the same time symmetrically with respect to the central axis of the gas ejection section 12f, and it is easy to make the liquid medicine 10 induced by the shearing of the gas supply gas G be sprayed evenly.

[0101] The opening area of ​​the gas ejection section 12f is smaller than the opening area of ​​the liquid dispensing section (dispensing pipe 13).

[0102] "Opening area" refers to the area of ​​the opening on the plane in which the opening is formed. That is, the opening area of ​​the gas ejection section 12f is the area of ​​the opening on the orthogonal plane 12n extending in a direction orthogonal to the injection direction of the supplied gas G. The opening area of ​​the discharge pipe 13 is the opening on the front end face of the discharge pipe 13 (the openings other than slits 13b and 13c, which in this embodiment are...). Figure 4 The area of ​​the circular portion shown.

[0103] According to the above structure, since the opening area of ​​the gas ejection section 12f is smaller than the opening area of ​​the liquid dispensing section (dispensing pipe 13), the pressure loss (energy loss) of the delivery gas G can be increased to reduce wind force and increase wind speed. By injecting this delivery gas G into the liquid medicine 10, it is possible to promote the liquid medicine 10 to become a fine mist.

[0104] The flow path diameter of the gas ejection section 12f is 0.3 mm or more and 0.6 mm or less.

[0105] In this way, with a flow path diameter of 0.3 mm or more and 0.6 mm or less through the gas ejection section 12f, the ejection volume of the gas delivery gas G can be ensured and the flow rate can be increased, thereby making the particles of the liquid medicine 10 sprayed with the gas delivery gas G finer.

[0106] [Eaves]

[0107] The head 12 also has an eaves 12i at its front end, separated by a gas ejection portion 12f. The eaves 12i is located on the side opposite to the part where the ejection pipe 13 is located.

[0108] The rim 12i is provided to cover the front end of the gas ejection section 12f and the ejection pipe 13, and is formed to protrude further from the front end of the ejection pipe 13 based on the ejection direction of the liquid medicine 10. In particular, the rim 12i is formed into a gently sloping pointed shape.

[0109] Specifically, the eaves 12i are formed in such a way that the central portion in the width direction (in this embodiment, the direction in which the two discharge pipes 13 are arranged parallel to each other) protrudes to the far end, and the amount of protrusion from the head body 12b decreases as it moves toward both sides in the width direction.

[0110] More specifically, the eaves 12i protrudes from the head body 12b by a length more than twice the length of the discharge pipe 13 protruding from the head body 12b.

[0111] The eaves 12i thus formed function as a partition wall separating the gas ejection section 12f and the discharge pipe 13 from the surrounding environment. Therefore, the eaves 12i can suppress the influence of the surrounding environment on the gas ejected from the gas ejection section 12f, thereby maintaining the straightness of the spray of the liquid medicine 10.

[0112] Furthermore, the eaves 12i can suppress blockages in the gas ejection section 12f or the ejection tube 13 caused by bodily fluids adhering to organs or other structures due to contact between the ejection tube 13 and the expelled medication 10. Moreover, by forming the eaves 12i into a pointed shape, it is easy to insert the nozzle X into the cannula needle (not shown) from the head 12.

[0113] <Regarding spray results>

[0114] Next, the main references Figure 5 and Figure 6 The spraying results of the drug solution 10 based on the biological tissue adhesive coating tool 1 according to this embodiment (Example) and the spraying results of the drug solution 10 based on a conventional biological tissue adhesive coating tool (not shown) (Comparative Example) will be described.

[0115] Figure 5 This is a graph showing the wind force at each air pressure of the supplied gas G in the comparative examples and embodiments. Figure 6 This is a graph showing the particle size of the sprayed liquids in the comparative examples and embodiments.

[0116] A comparative example is shown of a biological tissue adhesive application tool (not shown) in which no slit is formed in the ejection tube and the gas ejection portion does not protrude from the head body 12b.

[0117] Figure 5 The wind force shown is the load measured by a measuring instrument positioned 5 cm away from the gas ejector 12f when it vertically ejects the gas G from the gas ejector 12f.

[0118] Will Figure 5 The detailed values ​​shown in the chart are presented in Table 1.

[0119] [Table 1]

[0120]

[0121] like Figure 5 As shown in Table 1, in the embodiments of the biological tissue adhesive coating tool 1, the wind force can be suppressed by about 0.5 to about 0.6 times compared to the comparative example.

[0122] Moreover, in Figure 6 In the spray test shown, in the embodiment, compared to the comparative example, even if the air pressure of the gas G sprayed from the gas ejector 12f is as low as 0.07 MPa, fine-particle liquid medicine 10 can be applied to the target surface.

[0123] <Variation Example>

[0124] In the head 12 of the above embodiment, slits 13b and slits 13c are formed with the same length in the axial direction of the discharge tube 13, but the present invention is not limited to this structure.

[0125] Next, the main references Figure 7 The head 23 involved in the variant example will be explained. Figure 7 The diagram shows the head 23 involved in the modified example, and is a cross-sectional view of the front end of the nozzle X through the vertical section of the central axis of the discharge pipe 23 and the gas ejection section 12f.

[0126] The slit 23c, which is the outflow opening in this example, is formed with a shorter length than the slit 13c, which is the inflow opening. The base end of the slit 23c is provided on the extension line connecting the lower end of the gas ejection portion 12f and the base end of the slit 13c.

[0127] That is, slit 23c is formed on the extension line of the gas supply gas G that is ejected from gas ejection section 12f and passes through slit 13c.

[0128] By forming the discharge tube 23 in this way, the proportion of the drug solution 10 that is sheared by the gas G passing through the slit 13b flowing out of the slit 23c can be increased, relative to the proportion of unsheared drug solution 10 flowing out from the slit 23c. According to this structure, it is possible to suppress the dripping of the drug solution 10 before atomization.

[0129] In addition, the biological tissue adhesive coating tool 1 according to this embodiment has a liquid flow path formed in each of the two dispensing tubes 13.

[0130] However, the biological drug injection device according to the present invention is not limited to this structure; it may have more drug flow paths, or conversely, it may have only one. Similarly, the gas ejection section 12f is not limited to two; it may have more, or conversely, it may have only one.

[0131] Furthermore, in the above embodiment, a structure in which the expelled gas G is sprayed in parallel from the two gas ejection sections 12f has been described. Even with this structure, since the diameter of the ejection pipe 13 is small and the cross-sectional area of ​​the liquid medicine 10 passing through the ejection pipe 13 is sufficiently small, it is possible to properly mix the two liquid medicines 10.

[0132] However, the present invention is not limited to this structure, and may also have the following structure: in order to promote the mixing of the two liquid drugs 10, two gas ejection sections 12f extend in mutually intersecting directions so that the injection points of the gas delivery gas G ejected from the two gas ejection sections 12f intersect. In this case, it is sufficient to have an outlet pipe 13 and an inflow opening and an outflow opening formed in the outlet pipe 13 at the injection point of the gas delivery gas.

[0133] The above implementation methods incorporate the following technical concepts. (1)

[0135] A biological drug injection device, characterized in that it comprises:

[0136] Main body; and

[0137] The nozzle extends from the main body.

[0138] The nozzle has the following features:

[0139] A tubular liquid dispensing section is disposed at the front end of the nozzle and located within the dispensing internal space for the liquid; and

[0140] A gas ejector, located near the liquid dispensing section, sprays gas onto the liquid dispensing section to create a mist-like spray of the liquid.

[0141] An inflow opening is formed on the peripheral wall of the liquid dispensing section on the side of the gas ejection section, and an outflow opening is formed on the side opposite to the gas ejection section.

[0142] The gas ejection section sprays gas in a direction that intersects with the direction of the liquid being ejected from the liquid ejection section.

[0143] The inflow opening and the outflow opening are formed on the extension line of the injection direction of the gas ejected through the gas ejection section. (2)

[0145] According to the biological drug injection device described in (1), wherein,

[0146] In the liquid dispensing section, a circumferential portion is formed on the end side closer to the inlet opening and the outlet opening. (3)

[0148] According to the biological drug injection device described in (1) or (2), wherein,

[0149] The opening width on the outer periphery of the inflow opening is wider than the opening width on the inner periphery. (4)

[0151] According to the biological drug injection device described in (3), wherein,

[0152] The opening width on the outer periphery of the inflow opening is wider than the flow path diameter of the gas ejection portion. (5)

[0154] According to the biological drug injection device described in (3) or (4), wherein,

[0155] The opening width on the inner circumferential side of the inflow opening is narrower than the flow path diameter of the gas ejection portion. (6)

[0157] The biological drug injection device according to any one of (1) to (5), wherein,

[0158] The width of the opening on the outer periphery of the outflow opening is wider than the width of the opening on the inner periphery. (7)

[0160] The biological drug injection apparatus according to any one of (1) to (6), wherein,

[0161] At least one of the inflow opening and the outflow opening is formed as a slit and is formed to extend in the direction of the liquid dispensing portion. (8)

[0163] The biological drug injection apparatus according to any one of (1) to (7), wherein,

[0164] The opening area of ​​the gas ejection section is smaller than the opening area of ​​the liquid dispensing section. (9)

[0166] The biological drug injection apparatus according to any one of (1) to (8), wherein,

[0167] The liquid dispensing section extends further and protrudes more distally than the gas dispensing section.

[0168] The ejection opening of the gas ejection section is formed at an angle relative to a virtual plane orthogonal to the extending direction of the liquid dispensing section, protruding toward the front end of the liquid dispensing section as it moves away from the liquid dispensing section. (10)

[0170] According to the biological drug injection device described in (9), wherein,

[0171] The ejection opening is formed on a surface orthogonal to the direction of gas ejection. (11)

[0173] The biological drug injection device according to any one of (1) to (10), wherein,

[0174] The flow path diameter of the gas ejection section is 0.3 mm or more and 0.6 mm or less.

[0175] Industrial availability

[0176] According to the present invention, a biological drug injection device is provided that can atomize the drug solution into finer particles and spray it into the body cavity.

[0177] Explanation of reference numerals in the attached figures

[0178] 1-Biological tissue adhesive application tool (biological drug injection tool), 2-Main body, 2d-Syringe mounting port, 2g-Gas injection section, 2s-Space, 7-Plunger, 8-Plunger holder, 9-Air filter, 9a-Connection port, 10-Drug solution, 11-Extension section, 12-Head (front end), 12b-Head body, 12f-Gas ejection section, 12h-Matching section, 12i-Eaves, 12m-Ejection Opening, 12n-Orthogonal plane, 13-Dispensing tube (medicine dispensing part), 13a-Peripheral wall, 13b-Slit (inflow opening part), 13c-Slit (outflow opening part), 13d-Circumferential part, 17-Injector, 22-Head (front end part), 23-Dispensing tube, 23c-Slit (outflow opening part), 30-Regulator, 31-Gas delivery hose, 31a, 31b-Connector, G-Gas delivery gas, X-Nozzle.

Claims

1. A device for injecting a biological drug solution, characterized in that, Possessing: a main body portion; and a nozzle extending from the main body portion, the nozzle possessing: a tubular liquid medicine discharge portion provided at a tip end portion of the nozzle and discharging liquid medicine in an internal space; and a gas discharge portion located in the vicinity of the liquid medicine discharge portion, the liquid medicine being sprayed in mist form by gas being sprayed against the liquid medicine discharged from the liquid medicine discharge portion, an inflow opening portion being formed on a peripheral wall of the liquid medicine discharge portion on the side of the gas discharge portion, and an outflow opening portion being formed on the side opposite to the side of the gas discharge portion, the opening width on the outer periphery side of the inflow opening portion being wider than the opening width on the inner periphery side, the gas discharge portion spraying the gas in a direction intersecting the direction of discharge of the liquid medicine discharged from the liquid medicine discharge portion, the inflow opening portion and the outflow opening portion being formed on an extension line of the direction of spraying of the gas sprayed by the gas discharge portion.

2. The liquid medicine injection tool for living organisms according to claim 1, wherein an annular portion formed around the entire periphery is formed on the tip end side closer than the inflow opening portion and the outflow opening portion in the liquid medicine discharge portion.

3. The liquid medicine injection tool for living organisms according to claim 1 or 2, wherein the opening width on the outer periphery side of the inflow opening portion is wider than the flow path diameter of the gas discharge portion.

4. The liquid medicine injection tool for living organisms according to claim 1 or 2, wherein the opening width on the inner periphery side of the inflow opening portion is narrower than the flow path diameter of the gas discharge portion.

5. The liquid medicine injection tool for living organisms according to claim 1 or 2, wherein the opening width on the outer periphery side of the outflow opening portion is wider than the opening width on the inner periphery side.

6. The liquid medicine injection tool for living organisms according to claim 1 or 2, wherein at least either one of the inflow opening portion and the outflow opening portion is formed in a slit shape and is formed long in the direction of extension of the liquid medicine discharge portion.

7. The liquid medicine injection tool for living organisms according to claim 1 or 2, wherein the opening area of the gas discharge portion is smaller than the opening area of the liquid medicine discharge portion.

8. The liquid medicine injection tool for living organisms according to claim 1 or 2, wherein the liquid medicine discharge portion extends and projects further toward the distal side than the gas discharge portion, the discharge opening of the gas discharge portion is formed obliquely with respect to a virtual plane orthogonal to the direction of extension of the liquid medicine discharge portion in a manner projecting toward the tip end side of the liquid medicine discharge portion as it moves away from the liquid medicine discharge portion.

9. The liquid medicine injection tool for living organisms according to claim 8, wherein the discharge opening is formed on a plane orthogonal to the direction of spraying of the gas.

10. The liquid medicine injection tool for living organisms according to claim 1 or 2, wherein the flow path diameter of the gas discharge portion is 0.3 mm or more and 0.6 mm or less.

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