Functionalized repair stent and preparation method and application thereof

CN116650719BActive Publication Date: 2026-07-07SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
Filing Date
2023-07-19
Publication Date
2026-07-07

AI Technical Summary

Technical Problem

Existing vaginal reconstruction stents are prone to dislodgement after surgery, leading to a high closure rate and surgical failure. Furthermore, they lack effective sustained-release drug function, making it difficult to meet the regenerative needs of different tissues.

Method used

A functionalized repair scaffold is designed, comprising a tubular scaffold, a fibrous membrane, and specifically bound physiologically active molecules. Through a gradient controlled-release mechanism, it provides multi-level drug release and mechanical support, adapting to the regeneration rates of different tissues. A high-strength, biodegradable scaffold structure is prepared using melt electrowriting and electrospinning techniques.

Benefits of technology

It improves the success rate of vaginal reconstruction surgery, reduces the risk of stent dislodgement, provides multi-level drug release support, promotes tissue regeneration and repair, and adapts to the regeneration speed requirements of different tissues.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application provides a functionalized repair stent and a preparation method and application thereof. The functionalized repair stent comprises a tubular stent, a fiber membrane covering the tubular stent and physiologically active molecules specifically combined with the surface of the fiber membrane; or the functionalized repair stent comprises a collagen fiber bundle, a fiber membrane covering the collagen fiber bundle and physiologically active molecules specifically combined with the surface of the fiber bundle and the fiber membrane; or the functionalized repair stent comprises a collagen fiber bundle, physiologically active molecules specifically combined with the surface of the collagen fiber bundle and a tubular stent covering the collagen fiber bundle; the tubular stent comprises a tubular structure and a coating covering the tubular structure. In the application, the functionalized repair stent with certain strength and slow-release effect is prepared by designing the structure of the functionalized repair stent, the functionalized repair stent can be prepared semi-mechanically and automatically, the efficiency is high, the functionalized repair stent can be degraded in the body, a secondary operation is not needed and the size and shape are controllable.
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