A refrigeration device for premature ovarian failure gene detection

Abstract

A kind of cold storage device for early ovarian gene detection, it is related to gene cold storage device technical field, including box, cover, the upper end of box is connected with cover by hinge, the side of cover near the upper end of box is equipped with heat preservation pad, placing rack is installed in the inside of box, placing rack is circularly arranged, placing tube is movably installed in the inside of placing rack, the upper end of placing rack in the inside of box is provided with mounting plate, gear column is installed between placing tube and the inner wall of box by placing rack, gear column side is contacted with the inside of box by penetrating the inside of placing rack, the inside of box is provided with gear slot, and is engaged with the outside of gear column, the same gear slot as the inside of box is provided in the outside of placing tube, so that when rotating frame rotates, gear column can rotate under the action of gear slot, in turn drive placing tube to rotate, so that rotating tube changes the position close to refrigerating piece constantly, to achieve the effect of guaranteeing sample uniform cooling.

Description

Technical Field

[0001] This invention relates to the field of gene refrigeration device technology, and more specifically, to a refrigeration device for gene detection of premature ovarian failure. Background Technology

[0002] The ovary is a pair of gonads in the female animal body that produce eggs. It has two physiological functions: producing and releasing egg cells and secreting sex hormones. Ovaries need to be tested for premature aging genes over a long period of time. During the gene testing process, a refrigeration device is needed to refrigerate genes that cannot be tested temporarily in order to temporarily reduce the activity of the test sample and prevent it from deteriorating.

[0003] Existing ovarian gene cryopreservation devices, such as the cryopreservation box and gene cryopreservation device for gene sequencers disclosed in CN218781486U, include a box body, a lid, a cooling component and a glass tank, which can facilitate cooling of the storage tube to reduce sample activity. The elastic component allows the user to quickly remove the storage tube when opening the lid. The clamping block and two first springs can easily clamp storage tubes of different diameters, improving the practicality of the device.

[0004] However, when existing devices refrigerate genes, the tube containing the gene sample does not move, so the cooling device is always in contact with one side of the tube. This results in uneven freezing temperature of the gene sample inside, affecting the sample preservation effect. Furthermore, when removing samples from existing refrigeration devices, the entire device must be opened, and the specific sample that needs to be found cannot be found immediately. Each sample needs to be checked individually, which means that the remaining samples need to be exposed to room temperature for a long time, resulting in different types of damage. Summary of the Invention

[0005] The present invention aims to solve the technical problem in the prior art where the freezing temperature of gene samples is uneven, and the removal of a single sample easily leads to the other samples being exposed to room temperature.

[0006] The objectives and effects of this invention are achieved by the following specific technical means:

[0007] A refrigerated device for gene detection of premature ovarian failure includes a box and a cover. The upper end of the box is connected to the cover via a hinge. A heat-insulating pad is provided on the side of the cover near the upper end of the box. A circular placement rack is installed inside the box. A placement tube is movably installed inside the placement rack. An installation plate is provided inside the box corresponding to the upper end of the placement rack. An inlet is opened on the upper end of the installation plate corresponding to the side of the placement rack. A rotating block is fixedly connected to the middle of the upper end of the placement rack. The outer circumference of the rotating block has equidistant protrusions. A refrigeration mechanism is installed at the bottom of the box. A refrigeration fin is provided on the upper side of the refrigeration mechanism and passes through the placement rack. A rotating sleeve is movably installed inside the heat-insulating pad. The front of the rotating sleeve has an opening. A retaining plate is movably installed inside the rotating sleeve. The retaining plate is arc-shaped and has a toothed groove on the side of the retaining plate facing the center of the rotating sleeve. The toothed groove cooperates with the protrusions on the outer side of the rotating block.

[0008] The placement rack has a gear post installed between the placement tube and the inner wall of the box. One side of the gear post extends out of the placement rack and contacts the inner side of the box. The inner side of the box has a toothed groove. A transparent layer is provided in the middle of the placement tube. A right-angle prism is installed inside the placement rack on one side corresponding to the placement tube. A through groove is also provided at the upper end of the placement rack opposite to the right-angle prism. An observation strip is provided in the mounting plate above the right-angle prism. The observation strip is annular and made of transparent material.

[0009] Furthermore, the upper end of the box is concave, and a controller is installed on the front of the box.

[0010] Furthermore, multiple placement tubes are equidistantly arranged around the circumference inside the placement rack, and a cushioning pad is adhesively connected to the inner side of the inner wall of the placement tube.

[0011] Furthermore, the cooling element is arranged in a circular shape and is located on the side near the placement tube. There are two placement racks and placement inlets symmetrically installed inside the housing.

[0012] Furthermore, a small reduction motor is fixedly installed on one side of the cover, one end of the small reduction motor is connected to the rotating sleeve, the diameter of the rotating sleeve is larger than that of the rotating block, and four abutting plates are evenly distributed around the circumference inside the rotating sleeve.

[0013] Furthermore, a hinge is provided on the side of the abutment plate near the opening of the rotating sleeve, and the abutment plate is rotatably connected to the inner wall of the rotating sleeve through the hinge. A spring is arranged between the other side of the abutment plate extending into the interior of the rotating sleeve and the inner wall of the rotating sleeve.

[0014] Furthermore, the tooth groove meshes with the outer side of the gear column, and the outer side of the placement tube has the same tooth groove as the inner side of the box.

[0015] Furthermore, the right-angle prism and the transparent layer are set at the same height, and the placement frame has a through groove between the right-angle prism and the placement tube, and a cold light lamp bead is installed inside the through groove.

[0016] Furthermore, a switch plate is movably installed on the inner side of the mounting plate corresponding to the inlet. The switch plate is a circular plate with a diameter larger than the inlet. An extension rod is provided on the upper edge of the switch plate, and the extension rod extends out of the interior of the mounting plate. A cavity is provided inside the mounting plate for the switch plate to rotate.

[0017] Furthermore, a through hole is provided at the bottom end of the placement tube, and a through hole is also provided inside the placement rack corresponding to the lower side of the placement tube. Push blocks are installed on the left and right sides of the outside of the box, and a top rod is movably installed inside the box corresponding to the lower side of the placement rack. The top rod is L-shaped and one side is fixedly connected to the push block.

[0018] Beneficial effects:

[0019] A refrigeration device for gene testing of premature ovarian failure has the following beneficial effects:

[0020] 1. A rotating sleeve is movably installed inside the insulation pad. Inside the rotating sleeve, a retaining plate is movably installed. The retaining plate is arc-shaped, and four retaining plates are evenly spaced around the circumference of the rotating sleeve. A toothed groove is formed on the side of the retaining plate facing the center of the rotating sleeve, which engages with the protruding teeth on the outer side of the rotating block. A hinge is provided on the side of the retaining plate near the opening of the rotating sleeve, allowing the retaining plate to rotatably connect to the inner wall of the rotating sleeve via the hinge. A spring is arranged between the inner walls of the retaining plate extending into the rotating sleeve on the other side. This ensures that when the cover is rotated downwards and placed on the top of the box, the rotating sleeve fits over the outside of the rotating block. The retaining plate, under the action of the spring, can press firmly against the outside of the rotating block, thus preventing damage during small-scale deceleration. When the motor rotates, the clamping plate rotates outside the rotating block. When the tooth groove aligns with the convex tooth, the clamping plate and the rotating block mesh, thereby driving the rotating block and the placement frame to rotate together. A gear column is installed between the placement tube and the inner wall of the box through the placement frame. One side of the gear column extends out of the placement frame and contacts the inner side of the box. The inner side of the box has a tooth groove that meshes with the outer side of the gear column. The outer side of the placement tube has the same tooth groove as the inner side of the box. When the rotating frame rotates, the gear column rotates under the action of the tooth groove, which in turn drives the placement tube to rotate. This causes the rotating tube to continuously change its position close to the cooling chip, thereby ensuring uniform cooling of the sample.

[0021] 2. A transparent layer, made of transparent material, is located in the middle of the placement tube. A right-angle prism is installed on one side of the placement tube inside the placement rack, at the same height as the transparent layer. A through slot is formed between the placement rack and the right-angle prism and the placement tube, and a cold light bulb is installed inside the through slot. A through slot is also formed at the top of the placement rack relative to the right-angle prism. An observation strip, made of annular transparent material, is set above the right-angle prism inside the mounting plate. This allows the cold light bulb to illuminate one side of the transparent layer of the placement tube, and the image of the sample tube is reflected upwards onto the observation strip through the right-angle prism. When a specific sample tube needs to be retrieved, simply open the cover and manually rotate the rotating block. This rotates the placement rack and placement tube, aligning the label on the outside of the sample tube with the right-angle prism, allowing the specific sample tube to be observed and located without opening the entire device.

[0022] 3. A switch plate is movably installed on the inner side of the mounting plate corresponding to the inlet. The switch plate is circular with a diameter larger than the inlet. An extension rod is provided on the upper edge of the switch plate, extending through the interior of the mounting plate. A cavity is provided inside the mounting plate for the switch plate to rotate. By pinching the extension rod and rotating the switch plate to misalign it with the inlet, the sample tube can be inserted and removed. A through hole is provided at the bottom of the placement tube, and a through hole is also provided inside the placement rack corresponding to the lower side of the placement tube. Push blocks are installed on the left and right sides of the outside of the box, and a top rod is movably installed inside the box corresponding to the lower side of the placement rack. The top rod is L-shaped and fixedly connected to the push block on one side. When the sample tube to be removed is located, it is moved to the lower end of the inlet, and then the push block is pushed from the outside, causing the top rod to move upward through the through hole and push the sample tube out, thus completing the removal of the sample tube. Attached Figure Description

[0023] Figure 1 This is a three-dimensional schematic diagram of the entire invention.

[0024] Figure 2 This is a top view of the placement rack of the present invention.

[0025] Figure 3 This is a front cross-sectional view of the placement rack of the present invention.

[0026] Figure 4 For the present invention Figure 3 Enlarged diagram of point A in the middle.

[0027] Figure 5 For the present invention Figure 3 Enlarged diagram of point B in the middle.

[0028] Figure 6 This is a top cross-sectional view of the cover of the present invention.

[0029] Figure 7 For the present invention Figure 6 Enlarged view of point C.

[0030] Figure 8 This is a top cross-sectional view of the placement rack of the present invention.

[0031] Figure 9 For the present invention Figure 8 Enlarged view of point D in the middle.

[0032] Figure 1-9 Components: 1-Box body, 2-Lid body, 3-Insulation pad, 4-Mounting plate, 5-Rotating block, 6-Observation strip, 7-Placement inlet, 8-Switch plate, 9-Push block, 10-Rotating sleeve, 11-Placement rack, 12-Placement tube, 13-Buffer pad, 14-Right angle edge, 15-Refrigeration mechanism, 16-Refrigeration element, 17-Cold light bulb, 18-Gear column, 19-Gear groove, 20-Transparent layer, 21-Top rod, 22-Small geared motor, 23-Firming plate, 24-Hinge. Detailed Implementation

[0033] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

[0034] Reference Figure 1-9 A schematic diagram of the exploded structure and a schematic diagram of the planar structure of a refrigeration device for gene detection of premature ovarian failure.

[0035] A refrigerated device for gene detection of premature ovarian failure includes a box body 1 and a cover body 2. The upper end of the box body 1 is connected to the cover body 2 by a hinge. A heat-insulating pad 3 is provided on the side of the cover body 2 near the upper end of the box body 1. The upper end of the box body 1 is concave. A controller is installed on the front of the box body 1. The cover body 2 and the box body 1 are provided with corresponding locking mechanisms.

[0036] In the specific implementation, a placement rack 11 is installed inside the box 1. The placement rack 11 is circular. A placement tube 12 is movably installed inside the placement rack 11. Multiple placement tubes 12 are evenly distributed around the circumference inside the placement rack 11. A buffer pad 13 is glued to the inner side of the inner wall of the placement tube 12. A mounting plate 4 is provided inside the box 1 at the upper end corresponding to the placement rack 11. An inlet 7 is opened on the upper end of the mounting plate 4 corresponding to one side of the placement rack 11.

[0037] In the specific implementation, a rotating block 5 is fixedly connected to the middle of the upper end of the placement rack 11. The upper end of the rotating block 5 extends through the mounting plate 4. The outer circumference of the rotating block 5 is provided with equidistant protrusions. A cooling mechanism 15 is installed at the bottom of the box body 1. A cooling plate 16 is provided on the upper side of the cooling mechanism 15 and passes through the placement rack 11. The cooling plate 16 is arranged in a circular shape and is close to the side of the placement tube 12. There are two placement racks 12 and two placement inlets 7 symmetrically installed inside the box body 1.

[0038] In the specific implementation, a rotating sleeve 10 is movably installed inside the heat insulation pad 3. The rotating sleeve 10 has an opening on the front. A small reduction motor 22 is fixedly installed on one side of the cover 2. One end of the small reduction motor 22 is connected to the rotating sleeve 10. The diameter of the rotating sleeve 10 is larger than that of the rotating block 5. A pressing plate 23 is movably installed inside the rotating sleeve 10. The pressing plate 23 is arc-shaped. Four pressing plates 23 are equidistantly arranged on the circumference inside the rotating sleeve 5.

[0039] In specific implementation, the clamping plate 23 is provided with a toothed groove on the side facing the center of the rotating sleeve 10. The toothed groove cooperates with the outer protruding tooth of the rotating block 5. A hinge 24 is provided on the side of the clamping plate 23 near the opening of the rotating sleeve 10. The clamping plate 23 is rotatably connected to the inner wall of the rotating sleeve 10 through the hinge 24. A spring is provided between the other side of the clamping plate 23 extending into the interior of the rotating sleeve 10 and the inner wall of the rotating sleeve 10.

[0040] In a specific implementation, a gear column 18 is installed between the placement tube 12 and the inner wall of the box 1 in the placement rack 11. One side of the gear column 18 extends out of the placement rack 11 and contacts the inner side of the box 1. A toothed groove 19 is opened on the inner side of the box 1 and meshes with the outer side of the gear column 18. The outer side of the placement tube 12 is opened with the same toothed groove 19 as the inner side of the box 1.

[0041] In the specific implementation, a transparent layer 20 is provided in the middle of the inside of the placement tube 12. The transparent layer 20 is made of transparent material. A right-angle prism 14 is installed inside the placement rack 11 on one side corresponding to the placement tube 12. The right-angle prism 14 and the transparent layer 20 are set at the same height. A through groove is opened between the placement rack 11 and the placement tube 12 relative to the right-angle prism 14. A cold light bead 17 is installed inside the through groove.

[0042] In a specific implementation, a battery for powering the cold light bulb 17 is installed inside the placement rack 11. A through groove is also provided at the upper end of the placement rack 11 relative to the right angle prism 14. An observation strip 6 is provided in the mounting plate 4 above the right angle prism 14. The observation strip 6 is ring-shaped and made of transparent material.

[0043] In specific implementation, a switch plate 8 is movably installed on the inner side of the mounting plate 4 corresponding to the inlet 7. The switch plate 8 is a circular plate with a diameter larger than the inlet 7. An extension rod is provided on the upper edge of the switch plate 8. The extension rod extends out of the interior of the mounting plate 4. A cavity is opened inside the mounting plate 4 for the switch plate 8 to rotate.

[0044] In specific implementation, a through hole is opened at the bottom end of the placement tube 12, and a through hole is also opened inside the placement rack 11 corresponding to the lower side of the placement tube 12. Push blocks 9 are installed on the left and right sides of the outside of the box 1, and a top rod 21 is movably installed inside the box 1 corresponding to the lower side of the placement rack 11. The top rod 21 is L-shaped and one side is fixedly connected to the push block 9.

[0045] Working principle:

[0046] First, a circular placement rack 11 is installed inside the housing 1. Multiple placement tubes 12 are movably installed inside the rack 11, arranged equidistantly around the circumference of the rack 11. A cushioning pad 13 is adhesively attached to the inner wall of each placement tube 12. A mounting plate 4 is installed inside the housing 1, corresponding to the upper end of the rack 11. An inlet 7 is provided on the mounting plate 4, corresponding to the upper end of one side of the rack 11, allowing test tubes containing gene samples to be placed into the placement tubes 12 of the rack 11. A rotating block 5 is fixedly connected to the middle of the upper end of the rack 11, with its upper end extending out of the mounting plate 4. Equidistant teeth are provided on the outer circumference of the rotating block 5. A cooling mechanism 15 is installed at the bottom of the housing 1. A cooling plate 16 is installed on the side of the placement rack 11, which is circular and located near the placement tube 12. Two placement racks 11 and placement inlets 7 are symmetrically installed inside the cabinet 1. When the refrigeration mechanism 15 operates, the cooling plate 15 transfers the required low temperature for refrigeration to the placement rack 11, thus achieving a cooling effect. A rotating sleeve 10 is then movably installed inside the insulation pad 3. The rotating sleeve 10 has an opening on its front. A small reduction motor 22 is fixedly installed on one side of the cover 2, with one end connected to the rotating sleeve 10. The diameter of the rotating sleeve 10 is larger than that of the rotating block 5. A retaining plate 23 is movably installed inside the rotating sleeve 10. The retaining plate 23 is arc-shaped and equidistant from each other on the circumference of the rotating sleeve 5. Four clamping plates are provided. The clamping plate 23 has a toothed groove on the side facing the center of the rotating sleeve 10. The toothed groove engages with the outer protruding teeth of the rotating block 5. A hinge 24 is provided on the side of the clamping plate 23 near the opening of the rotating sleeve 10. The clamping plate 23 is rotatably connected to the inner wall of the rotating sleeve 10 through the hinge 24. A spring is arranged between the inner walls of the clamping plate 23 extending into the rotating sleeve 10. This allows the rotating sleeve 10 to fit over the outer side of the rotating block 5 when the cover 2 is rotated downwards and placed on top of the box 1. The clamping plate 23 can then be pressed tightly against the outer side of the rotating block 5 under the action of the spring. When the small reduction motor 22 rotates, the clamping plate 23 can rotate outside the rotating block 5. When the toothed groove aligns with the protruding teeth, the clamping plate 23 can engage with the rotating block 5. This causes the rotating block 5 and the placement rack 11 to rotate together. A gear post 18 is installed between the placement tube 12 and the inner wall of the housing 1 within the placement rack 11. One side of the gear post 18 extends out of the placement rack 11 and contacts the inner side of the housing 1. A toothed groove 19 is provided on the inner side of the housing 1, meshing with the outer side of the gear post 18. The outer side of the placement tube 12 has the same toothed groove 19 as the inner side of the housing 1. This allows the gear post 18 to rotate under the action of the toothed groove 19 when the placement rack 11 rotates, which in turn drives the placement tube 12 to rotate. This causes the placement tube 12 to continuously change its position relative to the cooling chip 16, thereby ensuring uniform cooling of the sample. A transparent layer 20, made of transparent material, is provided in the middle of the interior of the placement tube 12.A right-angle prism 14 is installed inside the placement rack 11 on one side corresponding to the placement tube 12. The right-angle prism 14 and the transparent layer 20 are set at the same height. A through groove is opened between the placement rack 11 and the right-angle prism 14 and the placement tube 12, and a cold light bead 17 is installed inside the through groove. A through groove is also opened at the upper end of the placement rack 11 corresponding to the right-angle prism 14. An observation strip 6 is set inside the mounting plate 4 above the right-angle prism 14. The observation strip 6 is made of a ring-shaped transparent material, which allows the cold light bead 17 to illuminate one side of the transparent layer 20 of the placement tube 12, and reflects the image of the sample tube upwards onto the observation strip 6 through the right-angle prism 14. When a specific sample tube needs to be taken out, simply open the cover 2 and manually rotate the rotating block 5. This rotates the placement rack 11 and the placement tube 12, aligning the label on the outside of the sample tube with the right-angle prism 14. Thus, the required specific sample tube can be observed and found without opening the entire device. Next, a switch plate 8 is movably installed on the inner side of the mounting plate 4 corresponding to the inlet 7. The switch plate 8 is a circular plate with a diameter larger than the inlet 7. An extension rod is provided on the upper edge of the switch plate 8, extending through the interior of the mounting plate 4. A cavity is provided inside the mounting plate 4 for the switch plate 8 to rotate. By pinching the extension rod and rotating the switch plate 8, it is displaced from the inlet 7, thus achieving the effect of inserting and removing the sample tube. A through hole is provided at the bottom end of the placement tube 12, and a through hole is also provided inside the placement rack 11 corresponding to the lower side of the placement tube 12. Push blocks 9 are installed on the left and right sides of the outside of the box 1, and a top rod 21 is movably installed inside the box 1 corresponding to the lower side of the placement rack 11. The top rod 21 is L-shaped and fixedly connected to the push block 9 on one side. When the sample tube to be removed is found, it is moved to the lower end of the inlet 7, and then the push block 9 is pushed from the outside, causing the top rod 21 to move upward through the through hole and push the sample tube out, thus completing the removal of the sample tube.

Claims

1. A refrigerated device for gene detection of premature ovarian failure, comprising a box body (1) and a cover body (2), wherein a heat-insulating pad (3) is provided on the side of the cover body (2) near the upper end of the box body (1), a placement rack (11) is installed inside the box body (1), the placement rack (11) is circular, a placement tube (12) is movably installed inside the placement rack (11), a plurality of placement tubes (12) are equidistantly arranged on the inner circumference of the placement rack (11), a buffer pad (13) is adhesively connected to the inner side of the inner wall of the placement tube (12), an installation plate (4) is provided inside the box body (1) corresponding to the upper end of the placement rack (11), an inlet (7) is opened on the upper end of the installation plate (4) corresponding to the side of the placement rack (11), a rotating block (5) is fixedly connected to the middle of the upper end of the placement rack (11), and the outer circumference of the rotating block (5) is equidistantly arranged. The box (1) is equipped with a refrigeration mechanism (15) at the bottom of the box (1). The refrigeration mechanism (15) is equipped with a refrigeration chip (16) that passes through the placement rack (11) on the upper side. The refrigeration chip (16) is arranged in a circular shape and is close to the placement tube (12). The heat insulation pad (3) is movably installed with a rotating sleeve (10). The rotating sleeve (10) is movably installed with a pressing plate (23). The pressing plate (23) is arc-shaped. The pressing plate (23) has a toothed groove on the side facing the center of the rotating sleeve (10). The toothed groove cooperates with the outer protruding tooth of the rotating block (5). The pressing plate (23) is equipped with a hinge (24) on the side near the opening of the rotating sleeve (10). The pressing plate (23) extends into the interior of the rotating sleeve (10) and a spring is arranged between the other side of the pressing plate (23) and the inner wall of the rotating sleeve (10). The placement rack (11) has a gear column (18) installed between the placement tube (12) and the inner wall of the box (1). The inner side of the box (1) has a toothed groove (19). The middle of the placement tube (12) has a transparent layer (20). The placement rack (11) has a right-angle prism (14) installed on one side of the placement tube (12). The right-angle prism (14) and the transparent layer (20) are set at the same height. The placement rack (11) has a through groove between the right-angle prism (14) and the placement tube (12). The through groove has a cold light lamp bead (17). The mounting plate (4) has an observation strip (6) above the right-angle prism (14). The observation strip (6) is made of annular transparent material. The mounting plate (4) is movably mounted with a switch plate (8) on the inner side of the inlet (7). An extension rod is provided on the upper edge of the switch plate (8), and the extension rod extends out of the mounting plate (4). A through hole is opened at the bottom end of the placement tube (12). A top rod (21) is movably mounted on the lower side of the placement rack (11) inside the box (1). The top rod (21) is L-shaped and has a push block (9) connected to one side. When the placement rack (11) rotates, the gear column (18) rotates under the action of the tooth groove (19), which in turn drives the placement tube (12) to rotate, so that the placement tube (12) continuously changes its position close to the cooling chip (16). An observation strip (6) is set above the right-angle prism (14) in the mounting plate (4), so that the cold light bead (17) can illuminate one side of the transparent layer (20) of the placement tube (12), and reflect the image of the sample tube upward to the observation strip (6) through the right-angle prism (14). After finding the test tube to be taken out, move it to the lower end of the placement port (7), and then push the push block (9) from the outside, so that it drives the push rod (21) to move upward through the through hole and push the test tube out.

2. The refrigeration device for gene detection of premature ovarian failure according to claim 1, characterized in that, A small reduction motor (22) is fixedly installed on one side of the cover (2). One end of the small reduction motor (22) is connected to the rotating sleeve (10). The diameter of the rotating sleeve (10) is larger than that of the rotating block (5).

3. The refrigeration device for gene detection of premature ovarian failure according to claim 1, characterized in that, The placement rack (11) and the placement entrance (7) are symmetrically installed in two inside the box (1).

4. The refrigeration device for gene detection of premature ovarian failure according to claim 1, characterized in that, The upper end of the box (1) is concave, and a controller is installed on the front of the box (1).

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