Liquid biopsy kit

Abstract

This utility model discloses a liquid biopsy kit, belonging to the field of medical reagent storage technology. The device includes a box with an openable cover at the top and support legs at the bottom. Inside, there is a pull-out placement plate with multiple slots for different reagent tube sizes. The rear of the box has a storage compartment with a cooling mechanism, which cools the reagent tubes through a ventilation structure. The bottom of the box has a buffer plate, and each placement slot has an independent buffer pad to effectively improve placement stability. The inside of the cover has a storage compartment and elastic pads to cushion impacts in case of drops, preventing damage to the reagent tubes. This utility model has a compact structure, high storage safety, strong adaptability, and is easy to clean and maintain. It is suitable for the cold storage and transportation management of liquid samples.

Description

Technical Field

[0001] This utility model relates to the field of reagent tube storage technology, and in particular to liquid biopsy kits. Background Technology

[0002] Liquid biopsy, as an emerging non-invasive testing method, has been widely used in fields such as early cancer screening and precision medicine. The samples tested mainly include bodily fluids such as blood, urine, and pleural or peritoneal fluid. Liquid biopsy kits play a crucial role in sample collection, preservation, transportation, and experimental procedures. To ensure the stability of the active ingredients in the kit and the accuracy of the test results, the reagent tubes are typically stored at low temperatures and protected from external forces such as vibration and impact.

[0003] Currently, most reagent kit storage devices on the market are simple refrigerated containers lacking specific design features. They cannot effectively accommodate reagent tubes of different sizes, and are prone to problems such as tube misalignment, breakage, and interference during transportation or handling. Furthermore, some storage devices are inconvenient to replace or clean during use, and have limited temperature control, affecting storage safety and efficiency.

[0004] For example, a reagent kit for cervical cancer marker detection described in patent number CN211732313U solves the problem of unstable clamping or inconvenience in removing test tubes during the transfer of cervical biopsies, which easily leads to test tube damage. The kit includes a box body with an inner liner fixedly connected inside. Multiple slots with openings at the top are provided on the inner liner. Test tubes are placed inside the slots. A positioning device is provided at the bottom of the slot's inner cavity. The positioning device includes a fixing block with multiple L-shaped rods evenly distributed around its circumference. Each L-shaped rod is rotatably connected to the box body via a pin, and a torsion spring is sleeved on the pin. The two ends of the torsion spring are fixedly connected to the L-shaped rod and the fixing block, respectively. A first top block is provided inside the space enclosed by the multiple L-shaped rods, located below the L-shaped rods. A guide rod is fixedly connected to the first top block, penetrating downwards through the box body and slidingly connected to it. This invention facilitates the insertion and removal of test tubes by medical personnel, making it easy and convenient, without causing damage to the test tubes, and ensuring the stability of the test tubes during transport. Although the above technical solution can realize the storage of reagent tubes and facilitate the retrieval of reagent tubes, the above device cannot meet the function of low-temperature storage of reagent tubes, and the buffer structure at the bottom of the reagent tube is complex. It is extremely troublesome to clean its structure after long-term use. In addition, the inner lining structure is fixedly connected to the box body, making subsequent cleaning and replacement extremely inconvenient.

[0005] To address the aforementioned issues, there is an urgent need for a reagent kit storage box that features rapid retrieval and placement, information recording and retrieval capabilities, and excellent sealing and anti-contamination performance. Utility Model Content

[0006] The purpose of this invention is to overcome the shortcomings of the existing technology and provide a liquid biopsy kit.

[0007] The purpose of this utility model is achieved as follows: a liquid biopsy kit includes a box body, the upper part of which is provided with an openable and closable cover, and the bottom of the box body is provided with support legs. The support legs can be selected as needed and the support leg mechanism can be adjusted up and down without technical limitations. The box body is provided with a pull-out placement plate, which can be easily replaced or cleaned. (The placement plates with different specifications of placement slots can be replaced as needed. Different specifications of placement slots correspond to different types of reagent tubes, which can increase the applicability of this device.) A storage slot is opened on the rear side of the box body, and a cooling mechanism is provided in the storage slot. A ventilation plate is provided on the rear side of the storage slot. Multiple placement slots are evenly opened on the placement plate, and corresponding types of reagent tubes can be placed in the placement slots.

[0008] Furthermore, a ventilation opening is provided on the rear side of the box. The cold air produced by the ventilation mechanism can enter the box through the ventilation opening to cool the reagent tubes. (A ventilation hole can be set at a suitable position inside the box, and a one-way valve can be installed at the ventilation hole to allow gas to overflow outward, increasing the flow of cold air into the box. Alternatively, other methods can be used to allow cold air to enter the box. This is existing technology and is not considered a technical limitation.)

[0009] Furthermore, a retaining ring is provided inside the box, which is fixedly connected to the inner side of the box. The lower outer side of the placement plate is recessed inward, and the placement plate can be placed on the retaining ring in a way that allows it to move up and down. A lifting groove is provided on the upper surface of the placement plate, which allows for quick picking and placing of the placement plate.

[0010] When using this invention, open the cover and place the reagent tube containing the liquid to be tested into the placement slot on the placement plate. The lower end of the reagent tube contacts the corresponding buffer pad below. Since the buffer pad has a certain elasticity, it can increase the stability of the reagent tube when placed. The depth of the buffer pad varies depending on the weight of the different reagent tubes. Each reagent tube has a corresponding buffer pad at its lower end that does not interfere with each other. This is more stable when placing the reagent tube than when the entire buffer pad (such as buffer cotton) is placed at the bottom. If the entire buffer pad is placed at the bottom, and one of the reagent tubes is heavier, it may exert a greater squeezing force on the buffer pad, which may cause the reagent tubes in the nearby placement slots to be affected and move downwards (i.e., mutual interference will occur when the reagent tubes are placed).

[0011] Next, close the cover. A storage compartment is set on top of the cover. The upper surface of the storage compartment is flush with the upper surface of the box, which makes it easy to pick up and place reagent tubes for identification (since the reagent tubes are labeled, the upper part of the reagent tubes protrudes from the box for easy identification of the labels). At the same time, it does not affect the storage of reagent tubes. An elastic gasket is set in the storage compartment to prevent damage to the reagent tubes in case of accidents (such as the box falling to the ground, hard collision between the reagent tubes and the cover).

[0012] After the cover is closed, since the storage compartment is smaller than the placement plate, the cover, together with the retaining ring, can limit the placement plate and prevent it from moving up and down.

[0013] The chamber is then cooled by a refrigeration mechanism. The refrigeration mechanism is existing technology and will not be described in detail. It is sufficient to achieve the refrigeration function. (For example, a refrigeration machine can be used, or ice cubes can be placed inside the chamber for refrigeration. There are no technical restrictions.) The cold air can directly contact the reagent tubes through the strip slots one and two on the placement plate, effectively achieving the refrigeration and cooling effect on the reagent tubes.

[0014] Beneficial effects: This utility model has the following technical effects when used:

[0015] 1. High adaptability and versatility: The detachable placement plate design allows for the replacement of matching slots with different reagent tube models, improving the applicability of the equipment and facilitating switching and expansion for different experimental needs.

[0016] 2. High-efficiency cooling protection: The device is equipped with a cooling mechanism. Cold air can reach the surrounding area of ​​the reagent tube through the ventilation structure and strip groove, achieving rapid and uniform cooling treatment, effectively extending the stability and activity of the reagent.

[0017] 3. Shock-absorbing and buffering structure: The buffering structure with independent buffer pads effectively avoids interference caused by the vertical movement of adjacent reagent tubes due to pressure on the overall buffer layer, improving placement stability and shock resistance, and reducing the risk of damage during drops or handling.

[0018] 4. Easy to operate and maintain: The placement plate has a pull-out groove for easy and quick removal or replacement. The combination of elastic pads and buffer components enhances the safety and ease of operation during reagent tube placement.

[0019] 5. Limiting protection design: The cover has a storage compartment. The elastic gasket inside the storage compartment can enhance the cushioning effect of the cover. When the cover is closed, it works with the retaining ring to effectively limit the placement plate and prevent the placement plate from shifting during transportation or use and affecting reagent storage.

[0020] In summary, this liquid biopsy kit storage device not only improves the safety, adaptability, and environmental control of reagent storage, but also provides high convenience and reliable assurance for experimental operations and reagent management. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the utility model.

[0022] Figure 2 This is a schematic diagram of the rear structure of the utility model.

[0023] Figure 3 This is a schematic diagram of the cover plate of the utility model after it is opened.

[0024] Figure 4 This is a partial structural cross-sectional view of the box of the utility model.

[0025] Figure 5 This is a schematic diagram of the structure of the placement plate proposed for the utility model.

[0026] Figure 6 This is a partial structural schematic diagram of the utility model.

[0027] Explanation of reference numerals in the attached figures:

[0028] 1. Box body, 2. Cover plate, 3. Support push, 4. Ventilation plate, 5. Elastic gasket, 6. Placement slot, 7. Placement plate, 8. Lifting slot, 9. Retaining ring, 10. Strip groove one, 11. Buffer plate, 12. Buffer gasket, 13. Ventilation port, 14. Refrigeration mechanism. Detailed Implementation

[0029] Example 1, such as Figure 1-6 As shown, the purpose of this utility model is achieved as follows: a liquid biopsy kit includes a box body 1. The upper part of the box body 1 is provided with an openable and closable cover plate 2, and the bottom of the box body 1 is provided with support legs. The support legs can be selected as needed and the support leg mechanism can be adjusted up and down without technical limitations. The box body 1 is provided with a pull-out placement plate 7, which can be easily replaced or cleaned. (The placement plate 7 can be replaced with different specifications of placement slots 6 as needed. Different specifications of placement slots 6 correspond to different types of reagent tubes, which can increase the applicability of this device.) A storage slot is opened on the rear side of the box body 1. A cooling mechanism 14 is provided in the storage slot. A ventilation plate 4 is provided on the rear side of the storage slot. Multiple placement slots 6 are evenly opened on the placement plate 7. The placement slots 6 can hold reagent tubes of the corresponding type.

[0030] A ventilation opening 13 is provided on the rear side of the inner chamber 1. The cold air produced by the ventilation mechanism can enter the chamber 1 through the ventilation opening 13 to cool the reagent tubes. (A ventilation hole can be set at a suitable position inside the chamber 1, and a one-way valve can be installed at the ventilation hole to allow gas to overflow outward, increasing the flow of cold air inside the chamber 1. Alternatively, other methods can be used to allow cold air to enter the chamber 1. This is existing technology and no technical limitations are imposed.)

[0031] A retaining ring 9 is provided inside the box 1. The retaining ring 9 is fixedly connected to the inner side of the box 1. The lower outer side of the placement plate 7 is recessed inward. The placement plate 7 can be placed on the retaining ring 9 and can be moved up and down. A lifting groove 8 is provided on the upper surface of the placement plate 7. The placement plate 7 can be quickly picked up and put down through the lifting groove 8.

[0032] A storage compartment is provided on the inner side of the lower surface of the cover plate 2, and an elastic pad 5 is installed inside the storage compartment. The storage compartment is located directly above the placement plate 7. The size of the storage compartment is smaller than the size of the placement plate 7. A buffer plate 11 is provided at the bottom of the box body 1. The buffer plate 11 is divided into multiple buffer slots. Each placement slot 6 on the placement plate 7 corresponds to a buffer slot, and a buffer pad 12 is installed inside the buffer slot. Both the elastic pad 5 and the buffer pad 12 are made of elastic material to cushion the reagent tubes.

[0033] Strip groove two is interconnected with strip groove one 10. Strip groove one 10 is perpendicular to strip groove two, and each placement slot 6 has a corresponding strip groove one 10 below it, which can increase the contact area between the reagent tube and the cold air and achieve rapid cooling.

[0034] When using this invention, open the cover plate 2 and place the reagent tube containing the liquid to be tested into the placement slot 6 on the placement plate 7. The lower end of the reagent tube contacts the corresponding buffer pad 12 below. Since the buffer pad 12 has a certain elasticity, it can increase the stability of the reagent tube when placed. The concave size of the buffer pad 12 varies depending on the weight of the different reagent tubes. Each reagent tube has a corresponding buffer pad 12 at its lower end that does not interfere with each other. This is more stable when placing the reagent tube than when the entire buffer pad 12 (buffer cotton, etc.) is placed at the bottom. If the entire buffer pad 12 is placed at the bottom, and one of the reagent tubes is heavier, it may cause the reagent tubes in the nearby placement slot 6 to be affected and move downwards (i.e., mutual interference will occur when the reagent tubes are picked up and placed).

[0035] Next, close the cover plate 2. A storage compartment is set above the cover plate 2. The upper surface of the placement plate 7 is flush with the upper surface of the box 1, which makes it easy to pick up and place the reagent tubes for identification (since the reagent tubes are labeled, the upper part of the reagent tubes protrudes outside the box 1, making it easy to identify the labels). At the same time, it does not affect the storage of the reagent tubes. An elastic gasket 5 is set in the storage compartment to prevent damage to the reagent tubes in case of accidents (such as the box 1 falling to the ground, hard collision between the reagent tubes and the cover plate 2, etc.).

[0036] After the cover plate 2 is closed, since the size of the storage compartment is smaller than the size of the placement plate 7, the cover plate 2, together with the retaining ring 9, can limit the placement plate 7 and prevent it from moving up and down.

[0037] The cooling mechanism 14 then cools the inside of the box 1. The cooling mechanism 14 is existing technology and will not be described in detail. It is sufficient to achieve the cooling function. (For example, a refrigeration machine can be used, or ice cubes can be placed to cool the inside of the box 1. There are no technical restrictions.) The cold air can directly contact the reagent tube through the strip groove 10 and strip groove 2 on the placement plate 7, effectively achieving the refrigeration and cooling effect on the reagent tube.

[0038] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0039] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. For those skilled in the art, the present utility model can have various modifications and variations. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A liquid biopsy kit comprising a box, characterized in that: The upper part of the box is provided with an openable cover, the bottom of the box is provided with support legs, the inside of the box is provided with a pull-out placement plate, the rear side of the box is provided with a storage slot, the storage slot is provided with a refrigeration mechanism, the rear side of the storage slot is provided with a ventilation plate, and multiple placement slots are evenly provided on the placement plate. A ventilation opening is provided on the rear side of the inner body of the box; The box is equipped with a retaining ring, which is fixedly connected to the inner side of the box. The lower outer side of the placement plate is recessed inward, and the placement plate can be moved up and down and placed on the retaining ring. The lower part of the placement plate has multiple strip grooves I, and the lower surface of the placement plate has multiple strip grooves II, which are interconnected with each other. Ventilation openings are provided on the rear side of the chamber, and the cold air produced by the ventilation mechanism enters the chamber through the ventilation openings. The cold air comes into direct contact with the reagent tubes through the first and second strip grooves on the placement plate, thereby achieving the effect of refrigerating and cooling the reagent tubes.

2. The liquid biopsy kit of claim 1, wherein: The upper surface of the placement plate is provided with a lifting groove.

3. The liquid biopsy kit of claim 1, wherein: A storage compartment is provided on the inner side of the lower surface of the cover plate, and an elastic gasket is provided inside the storage compartment.

4. The liquid biopsy kit of claim 3, wherein: The storage compartment is smaller than the placement plate.

5. The liquid biopsy kit of claim 1, wherein: A buffer plate is provided at the bottom of the box, and the buffer plate is divided into multiple buffer slots. Each placement slot on the placement plate corresponds to a buffer slot below it, and a buffer pad is provided in the buffer slot.

6. The liquid biopsy kit of claim 1, wherein: The first and second strip grooves are distributed perpendicularly.

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