A method for preparing a progesterone vaginal gel

Abstract

The application discloses a preparation method of a progesterone vaginal gel, relates to the technical field of gynecological medicine preparation, and realizes the preparation method of the progesterone vaginal gel by using a preparation device of the progesterone vaginal gel. The preparation device of the progesterone vaginal gel comprises a mixing kettle, a top plate is fixedly arranged at the top of the mixing kettle, a driving scraping mechanism is arranged inside the mixing kettle and at the inner side of the top plate, an oil phase preparation mechanism is arranged outside the driving scraping mechanism, a water phase preparation mechanism is arranged at the bottom outside the oil phase preparation mechanism, a premix preparation mechanism is arranged at the top outside the oil phase preparation mechanism, and the top plate and the water phase preparation mechanism are jointly provided with a driving supporting mechanism. The application can effectively shorten the transfer time of the premix and the oil phase, thereby improving the preparation efficiency of the gel product, and the residual oil phase can be recycled, thereby avoiding the waste of the oil phase and guaranteeing the quality of the gel product.

Description

Technical Field

[0001] This invention relates to the field of gynecological drug preparation technology, and in particular to a method for preparing a progesterone vaginal gel. Background Technology

[0002] Progesterone is an important component in regulating the female reproductive system. It mainly acts on the uterus, ovaries, breasts, and central nervous system. During the luteal phase of a woman's menstrual cycle and pregnancy, the concentration of progesterone in her blood is very high. In addition, endogenous progesterone can transform the endometrium from the proliferative phase to the secretory phase, maintaining normal physiological changes.

[0003] The invention patent with authorization announcement number CN 113288865 B discloses a method for preparing progesterone vaginal gel, which includes first preparing a premix of progesterone raw material and polymer, then adding it to an aqueous phase to obtain a hydrogel phase, and then adding an appropriate amount of sodium hydroxide solution to adjust the pH value to 2.5-3.5 to obtain the progesterone vaginal gel.

[0004] However, after practical application by those skilled in the art, the above preparation method still has some drawbacks. The most obvious one is that after the premix and oil phase are prepared, they need to be transferred between different containers to achieve the mixing of the premix with the aqueous phase and the mixing of the oil phase with the hydrogel phase. Since it is a transfer between different containers, when applied to industrial production operations, it will inevitably lead to an increase in the preparation time and a decrease in preparation efficiency.

[0005] Furthermore, due to its inherent characteristics, some of the oil phase will still adhere to the inside of the original container after the transfer is completed. Such incomplete transfer not only leads to the waste of the oil phase, but also affects the actual ratio of the oil phase to the hydrogel phase, thereby affecting the quality of the progesterone vaginal gel product.

[0006] Therefore, it is necessary to invent a method for preparing a progesterone vaginal gel to solve the above problems. Summary of the Invention

[0007] The purpose of this invention is to provide a method for preparing progesterone vaginal gel to solve the problems mentioned in the background art.

[0008] To achieve the above objectives, the present invention provides the following technical solution: a method for preparing a progesterone vaginal gel, wherein the method for preparing the progesterone vaginal gel is implemented using a progesterone vaginal gel preparation device, the progesterone vaginal gel preparation device includes a mixing vessel, a top plate is fixedly provided on the top of the mixing vessel, a driving scraping mechanism is provided inside the mixing vessel and on the inner side of the top plate, an oil phase preparation mechanism is provided outside the driving scraping mechanism, an aqueous phase preparation mechanism is provided at the bottom outside the oil phase preparation mechanism, and a premix preparation mechanism is provided at the top outside the oil phase preparation mechanism, a driving support mechanism is provided on the top plate and the outer side of the aqueous phase preparation mechanism, the premix preparation mechanism and the driving support mechanism divide the interior of the mixing vessel into an upper chamber, a middle chamber and a lower chamber, and an inner chamber is formed on the inner side of the oil phase preparation mechanism;

[0009] The drive scraping mechanism includes a drive shaft, a drive motor, a lifting plate, a connecting pipe, a rotating plate, and an oil-repellent scraper.

[0010] The drive shaft passes through the top of the mixing vessel cavity and the top plate, and is rotatably connected to the mixing vessel and the top plate via bearings. The drive motor is fixedly installed at the bottom of the mixing vessel cavity and is connected to the drive shaft. The lifting plate, connecting pipe, rotating plate and oil-repellent scraper are sequentially sleeved on the outside of the drive shaft from top to bottom. The lifting plate is connected to the drive shaft via a reciprocating thread. One end of the connecting pipe is rotatably nested at the bottom of the lifting plate via bearings, and the other end is rotatably nested at the top of the rotating plate via bearings. The rotating plate is slidably nested on the outside of the drive shaft in the vertical direction. The oil-repellent scraper is fixedly connected to the drive shaft.

[0011] The oil phase preparation mechanism includes an outer sleeve, an inner sleeve, a drive groove, a feeding groove, a clearance groove, a first magnet, and a first stirring rod;

[0012] The outer sleeve is slidably disposed at the top of the mixing vessel, and the inner sleeve is slidably nested inside the outer sleeve in the vertical direction. Multiple drive grooves are provided, and the multiple drive grooves are evenly opened at the top of the outer side of the outer sleeve. The feeding groove is opened at the middle of the outer side of the outer sleeve, and the clearance groove is opened at the bottom of the outer side of the outer sleeve. Two first magnets are provided, and the two first magnets are respectively fixedly disposed on both sides of the inner sleeve. Multiple first stirring rods are provided, and the multiple first stirring rods are evenly fixedly sleeved at the bottom of the outer side of the drive shaft.

[0013] Preferably, the aqueous phase preparation mechanism includes a rotating ring, a second magnet, a first fixed ring, a rotating rod, a drive gear, and a second stirring rod.

[0014] Preferably, the rotating ring is slidably sleeved on the outside of the inner sleeve, two second magnets are provided, and the two second magnets are respectively fixedly nested on both sides inside the rotating ring, the first fixed ring is rotatably sleeved on the outside of the rotating ring through a bearing and fixedly connected to the inner wall of the mixing vessel, the rotating rod is fixedly provided at the bottom of the rotating ring, the driving gear is fixedly provided at the bottom end of the rotating rod, and multiple second stirring rods are provided, with multiple second stirring rods evenly fixedly provided on the outside of the rotating rod.

[0015] Preferably, the drive support mechanism includes an inner plate, an intermediate ring, an outer ring, and an annular rack.

[0016] Preferably, the inner plate is rotatably sleeved on the bottom outside of the drive shaft via a bearing, the intermediate ring is rotatably sleeved on the outside of the inner plate via a bearing, the rotating rod passes through the intermediate ring and is rotatably connected to the intermediate ring via a bearing, the outer ring is rotatably sleeved on the outside of the intermediate ring via a bearing and is fixedly connected to the inner wall of the mixing vessel, and the annular rack is fixedly sleeved on the bottom of the outer ring and meshes with the drive gear.

[0017] Preferably, the premix preparation mechanism includes an annular baffle, a rotating sleeve, a driving slider, a stirring plate, a feeding channel, and a second fixing ring.

[0018] Preferably, the annular baffle is slidably sleeved on the outside of the outer sleeve and fixedly connected to the inner wall of the mixing vessel; the rotating sleeve is rotatably mounted on the top of the annular baffle and fits against the outer wall of the outer sleeve; two driving sliders are provided, each fixedly mounted on one side of the inside of the rotating sleeve; multiple stirring plates and multiple feeding channels are provided; multiple stirring plates are evenly fixedly mounted on the bottom of the outer side of the rotating sleeve and slidably fitted against the top of the annular baffle; multiple feeding channels are evenly opened on the bottom of the outer side of the rotating sleeve; the multiple stirring plates and multiple feeding channels are staggered; and the second fixing ring is rotatably sleeved on the top of the outer side of the rotating sleeve via a bearing and fixedly connected to the inner wall of the mixing vessel.

[0019] Preferably, the preparation method of the progesterone vaginal gel specifically includes the following steps:

[0020] S1. Add progesterone, carbomer and polycarbofil to the upper chamber, add glycerin, sorbic acid and purified water to the middle chamber, add liquid paraffin and hydrogenated palm oil to the inner chamber through the top opening of the outer sleeve, and then start the drive motor.

[0021] S2. After the drive motor starts, it drives the drive shaft to rotate continuously. When the drive shaft rotates, it drives the lifting plate to rise and at the same time drives the rotating plate to rotate. When the rotating plate rotates, it drives the outer sleeve and the inner sleeve to rotate. The lifting plate, through the connecting pipe, drives the outer sleeve to rise outside the inner sleeve.

[0022] S3. When the drive shaft rotates, it drives the first stirring rod to mix the material in the inner chamber. When the outer sleeve rotates, it drives the rotating sleeve to rotate through the drive groove and the drive slider. When the rotating sleeve rotates, it drives multiple stirring plates to mix the material in the upper chamber. When the inner sleeve rotates, it drives the rotating ring to rotate through the first magnet and the second magnet. When the rotating ring rotates, it drives the second stirring rod to mix the material in the middle chamber through the rotating rod.

[0023] S4. When the rotating rod rotates around the drive shaft, it drives the intermediate ring and the drive gear to rotate synchronously. At this time, under the action of the ring rack, the drive gear drives the rotating rod to rotate, which in turn causes the second stirring rod to revolve around the drive shaft and rotate synchronously around the rotating rod.

[0024] S5. When the lifting plate reaches the first threshold distance, the drive slider slides from the drive groove to the inside of the feeding groove. At this time, the rotating sleeve stops rotating. Then, the material mixed inside the annular baffle enters the inside of the feeding groove through multiple feeding channels, and then slides outward along the inner wall of the feeding groove, and is evenly sprinkled into the material in the middle chamber.

[0025] S6. When the lifting plate reaches the second threshold distance, the bottom of the inner cavity of the outer sleeve is in contact with the top of the outer side of the inner sleeve. As the lifting plate continues to rise, the outer sleeve drives the inner sleeve to rise synchronously. During the rise of the inner sleeve, the material in the inner cavity enters the middle cavity through the bottom opening of the inner sleeve and mixes with the material in the middle cavity. At this time, the first stirring rod also begins to mix the material in the middle cavity.

[0026] S7. When the lifting plate reaches the third threshold distance, the oil-draining scraper enters the inner side of the inner sleeve. Subsequently, as the lifting plate continues to rise, the oil-draining scraper begins to scrape off the material remaining on the inner wall of the inner sleeve and causes it to fall into the middle chamber. At the same time, the rotating ring also begins to scrape off the material remaining on the outer wall of the inner sleeve.

[0027] S8. When the lifting plate rises to the fourth threshold, the inner sleeve moves out from the inside of the rotating ring. At this time, the rotating ring stops rotating. When the lifting plate rises to the fifth threshold, the grease-repellent scraper reaches the bottom opening of the inner sleeve. Subsequently, as the first stirring rod continues to mix, the material in the middle chamber is used to produce the progesterone vaginal gel product.

[0028] S9. Output the finished progesterone vaginal gel. When the lifting plate rises to the sixth threshold, it moves to the top of the reciprocating thread on the outside of the drive shaft. As the drive shaft continues to rotate, the lifting plate moves down to reset.

[0029] The technical effects and advantages of this invention are as follows:

[0030] This invention comprises a drive scraping mechanism, an oil phase preparation mechanism, an aqueous phase preparation mechanism, a drive support mechanism, and a premix preparation mechanism. The drive scraping mechanism rotates and rises the oil phase preparation mechanism, which in turn drives the aqueous phase preparation mechanism and the premix preparation mechanism, thereby mixing the materials in the upper and middle chambers. As the oil phase preparation mechanism continues to rise, the blockages of the premix preparation mechanism and the drive support mechanism are successively released, allowing the materials in the upper and inner chambers to be successively fed into the middle chamber. Simultaneously, the drive scraping mechanism and the aqueous phase preparation mechanism work together to recover residual materials on the inner and outer walls of the oil phase preparation mechanism. Compared to similar devices or methods in the prior art, this invention effectively shortens the transfer time between the premix and the oil phase, thereby improving the preparation efficiency of the gel product. Furthermore, it allows for the recovery of residual oil phase, thus avoiding oil phase waste while ensuring the quality of the finished gel product. Attached Figure Description

[0031] Figure 1 This is a schematic diagram of the overall front cross-sectional structure of the present invention.

[0032] Figure 2 This is a front view cross-sectional structural diagram of the drive scraping mechanism of the present invention.

[0033] Figure 3 This is a frontal cross-sectional view of the oil phase preparation mechanism of the present invention.

[0034] Figure 4 This is a front view cross-sectional structural diagram of the aqueous phase preparation mechanism and the drive support mechanism of the present invention.

[0035] Figure 5 This is a frontal cross-sectional view of the premix preparation mechanism of the present invention.

[0036] In the diagram: 1. Mixing vessel; 2. Top plate; 3. Drive scraping mechanism; 31. Drive shaft; 32. Drive motor; 33. Lifting plate; 34. Connecting pipe; 35. Rotating plate; 36. Oil-repellent scraper; 4. Oil phase preparation mechanism; 41. Outer sleeve; 42. Inner sleeve; 43. Drive groove; 44. Feeding groove; 45. Clearance groove; 46. First magnet; 47. First stirring rod; 5. Aqueous phase preparation mechanism; 51. Rotating ring; 52. Second magnet; 53. First fixed ring; 54. Rotating rod; 55. Drive gear; 56. Second stirring rod; 6. Drive support mechanism; 61. Inner plate; 62. Intermediate ring; 63. Outer ring; 64. Annular rack; 7. Premix preparation mechanism; 71. Annular baffle; 72. Rotating sleeve; 73. Drive slider; 74. Stirring plate; 75. Feeding channel; 76. Second fixed ring. Detailed Implementation

[0037] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0038] Example 1

[0039] This invention provides, for example Figure 1-5 The invention discloses a method for preparing a progesterone vaginal gel. The method is implemented using a progesterone vaginal gel preparation device, which includes a mixing vessel 1. A top plate 2 is fixedly installed on the top of the mixing vessel 1. A drive scraping mechanism 3 is provided inside the mixing vessel 1 and on the inner side of the top plate 2. An oil phase preparation mechanism 4 is provided outside the drive scraping mechanism 3. An aqueous phase preparation mechanism 5 is provided at the bottom outside the oil phase preparation mechanism 4, and a premix preparation mechanism 7 is provided at the top outside the oil phase preparation mechanism 4. A drive support mechanism 6 is provided outside the top plate 2 and the aqueous phase preparation mechanism 5. The premix preparation mechanism 7 and the drive support mechanism 6 divide the interior of the mixing vessel 1 into an upper chamber, a middle chamber, and a lower chamber. An inner chamber is formed inside the oil phase preparation mechanism 4.

[0040] like Figure 2 and Figure 3 As shown, the drive scraping mechanism 3 includes a drive shaft 31, a drive motor 32, a lifting plate 33, a connecting pipe 34, a rotating plate 35, and an oil-repellent scraper 36. The drive shaft 31 passes through the top of the inner cavity of the mixing vessel 1 and the top plate 2, and is rotatably connected to the mixing vessel 1 and the top plate 2 via bearings. The drive motor 32 is fixedly installed at the bottom of the inner cavity of the mixing vessel 1 and is drive-connected to the drive shaft 31. The lifting plate 33, the connecting pipe 34, the rotating plate 35, and the oil-repellent scraper 36 are sequentially sleeved on the outside of the drive shaft 31 from top to bottom. The lifting plate 33 is connected to the drive shaft 31 via a reciprocating thread. One end of the connecting pipe 34 is rotatably nested at the bottom of the lifting plate 33 via a bearing, and the other end is rotatably nested at the top of the rotating plate 35 via a bearing. The rotating plate 35 is slidably nested on the outside of the drive shaft 31 in the vertical direction. The oil-repellent scraper 36 is fixedly connected to the drive shaft 31.

[0041] like Figure 2 and Figure 3As shown, the oil phase preparation mechanism 4 includes an outer sleeve 41, an inner sleeve 42, a drive groove 43, a feeding groove 44, a clearance groove 45, a first magnet 46, and a first stirring rod 47. The outer sleeve 41 is slidably disposed through the top of the mixing vessel 1. The inner sleeve 42 is slidably nested inside the outer sleeve 41 in the vertical direction. Multiple drive grooves 43 are provided, and the multiple drive grooves 43 are evenly opened on the top outer side of the outer sleeve 41. The feeding groove 44 is opened in the middle outer side of the outer sleeve 41. The clearance groove 45 is opened at the bottom outer side of the outer sleeve 41. Two first magnets 46 are provided, and the two first magnets 46 are respectively fixedly disposed on both sides of the inner sleeve 42. Multiple first stirring rods 47 are provided, and the multiple first stirring rods 47 are evenly fixedly sleeved on the bottom outer side of the drive shaft 31.

[0042] By setting up the aforementioned drive scraping mechanism 3 and oil phase preparation mechanism 4, the drive motor 32 can drive the drive shaft 31 to rotate continuously after starting. When the drive shaft 31 rotates, it drives the lifting plate 33 to rise, and at the same time drives the rotating plate 35 to rotate. When the rotating plate 35 rotates, it drives the outer sleeve 41 and the inner sleeve 42 to rotate. The lifting plate 33 drives the outer sleeve 41 to rise outside the inner sleeve 42 through the connecting pipe 34 and the rotating plate 35. When the drive shaft 31 rotates, it drives the first stirring rod 47 to mix the material in the inner chamber.

[0043] like Figure 4 As shown, the aqueous phase preparation mechanism 5 includes a rotating ring 51, a second magnet 52, a first fixed ring 53, a rotating rod 54, a drive gear 55, and a second stirring rod 56. The rotating ring 51 is slidably sleeved on the outside of the inner sleeve 42. There are two second magnets 52, which are respectively fixedly nested on both sides inside the rotating ring 51. The first fixed ring 53 is rotatably sleeved on the outside of the rotating ring 51 through a bearing and is fixedly connected to the inner wall of the mixing vessel 1. The rotating rod 54 is fixedly disposed at the bottom of the rotating ring 51, and the drive gear 55 is fixedly disposed at the bottom end of the rotating rod 54. There are multiple second stirring rods 56, which are evenly fixedly disposed on the outside of the rotating rod 54.

[0044] By setting up the above structure, when the inner sleeve 42 rotates, the first magnet 46 and the second magnet 52 drive the rotating ring 51 to rotate. When the rotating ring 51 rotates, the rotating rod 54 drives the second stirring rod 56 to mix the material in the middle chamber. In addition, as the inner sleeve 42 continues to rise, the rotating ring 51 begins to scrape off the material remaining on the outer wall of the inner sleeve 42, so that it falls into the middle chamber and is recycled.

[0045] like Figure 4As shown, the drive support mechanism 6 includes an inner plate 61, an intermediate ring 62, an outer ring 63, and an annular rack 64. The inner plate 61 is rotatably sleeved on the bottom outer side of the drive shaft 31 via a bearing. The intermediate ring 62 is rotatably sleeved on the outer side of the inner plate 61 via a bearing. The rotating rod 54 passes through the intermediate ring 62 and is rotatably connected to the intermediate ring 62 via a bearing. The outer ring 63 is rotatably sleeved on the outer side of the intermediate ring 62 via a bearing and is fixedly connected to the inner wall of the mixing vessel 1. The annular rack 64 is fixedly sleeved on the bottom of the outer ring 63 and meshes with the drive gear 55.

[0046] By setting the above structure, when the rotating rod 54 rotates around the drive shaft 31, it drives the intermediate ring 62 and the drive gear 55 to rotate synchronously. At this time, under the action of the ring rack 64, the drive gear 55 drives the rotating rod 54 to rotate, thereby causing the second stirring rod 56 to revolve around the drive shaft 31 and rotate synchronously around the rotating rod 54, thereby improving the stirring intensity of the second stirring rod 56.

[0047] like Figure 5 As shown, the premix preparation mechanism 7 includes an annular baffle 71, a rotating sleeve 72, a driving slider 73, a stirring plate 74, a feeding channel 75, and a second fixing ring 76. The annular baffle 71 is slidably sleeved on the outside of the outer sleeve 41 and fixedly connected to the inner wall of the mixing vessel 1. The rotating sleeve 72 is rotatably disposed on the top of the annular baffle 71 and fits against the outer wall of the outer sleeve 41. Two driving sliders 73 are provided, and the two driving sliders 73 are respectively fixedly disposed on both sides inside the rotating sleeve 72. Multiple stirring plates 74 and multiple feeding channels 75 are provided. Multiple stirring plates 74 are evenly fixedly disposed on the bottom of the outer side of the rotating sleeve 72 and slidably fitted against the top of the annular baffle 71. Multiple feeding channels 75 are evenly opened on the bottom of the outer side of the rotating sleeve 72. Multiple stirring plates 74 and multiple feeding channels 75 are staggered. The second fixing ring 76 is rotatably sleeved on the top of the outer side of the rotating sleeve 72 through a bearing and fixedly connected to the inner wall of the mixing vessel 1.

[0048] By setting the above structure, when the outer sleeve 41 rotates, it drives the rotating sleeve 72 to rotate through the drive groove 43 and the drive slider 73. When the rotating sleeve 72 rotates, it drives multiple stirring plates 74 to mix the material in the upper chamber. Subsequently, when the drive slider 73 slides from the drive groove 43 to the inside of the discharge groove 44, the rotating sleeve 72 stops rotating. Then, the material mixed inside the annular baffle 71 enters the inside of the discharge groove 44 through multiple discharge channels 75, and then slides outward along the inner wall of the discharge groove 44, and is then evenly sprinkled into the material in the middle chamber.

[0049] Example 2

[0050] The preparation method of the progesterone vaginal gel specifically includes the following steps:

[0051] S1. Add progesterone, carbomer and polycarbofil to the upper chamber, add glycerin, sorbic acid and purified water to the middle chamber, add liquid paraffin and hydrogenated palm oil to the inner chamber through the top opening of the outer sleeve 41, and then start the drive motor 32.

[0052] S2. After the drive motor 32 starts, it drives the drive shaft 31 to rotate continuously. When the drive shaft 31 rotates, it drives the lifting plate 33 to rise, and at the same time drives the rotating plate 35 to rotate. When the rotating plate 35 rotates, it drives the outer sleeve 41 and the inner sleeve 42 to rotate. The lifting plate 33 drives the outer sleeve 41 to rise outside the inner sleeve 42 through the connecting pipe 34 and the rotating plate 35.

[0053] S3. When the drive shaft 31 rotates, it drives the first stirring rod 47 to mix the material in the inner chamber. When the outer sleeve 41 rotates, it drives the rotating sleeve 72 to rotate through the drive groove 43 and the drive slider 73. When the rotating sleeve 72 rotates, it drives multiple stirring plates 74 to mix the material in the upper chamber. When the inner sleeve 42 rotates, it drives the rotating ring 51 to rotate through the first magnet 46 and the second magnet 52. When the rotating ring 51 rotates, it drives the second stirring rod 56 to mix the material in the middle chamber through the rotating rod 54.

[0054] S4. When the rotating rod 54 rotates around the drive shaft 31, it drives the intermediate ring 62 and the drive gear 55 to rotate synchronously. At this time, under the action of the ring rack 64, the drive gear 55 drives the rotating rod 54 to rotate, thereby causing the second stirring rod 56 to revolve around the drive shaft 31 and rotate synchronously around the rotating rod 54.

[0055] S5. When the lifting plate 33 reaches the first threshold distance, the driving slider 73 slides from the driving groove 43 to the inside of the feeding groove 44. At this time, the rotating sleeve 72 stops rotating. Then, the material mixed inside the annular baffle 71 enters the inside of the feeding groove 44 through multiple feeding channels 75, and then slides outward along the inner wall of the feeding groove 44, and is evenly sprinkled into the material in the middle chamber.

[0056] S6. When the lifting plate 33 rises to the second threshold, the bottom of the inner cavity of the outer sleeve 41 is in contact with the top of the outer side of the inner sleeve 42. As the lifting plate 33 continues to rise, the outer sleeve 41 drives the inner sleeve 42 to rise synchronously. During the rise of the inner sleeve 42, the material in the inner cavity enters the middle cavity through the bottom opening of the inner sleeve 42 and mixes with the material in the middle cavity. At this time, the first stirring rod 47 also begins to mix the material in the middle cavity.

[0057] S7. When the lifting plate 33 rises to the third threshold, the oil-repellent scraper 36 enters the inner side of the inner sleeve 42. Subsequently, as the lifting plate 33 continues to rise, the oil-repellent scraper 36 begins to scrape off the material remaining on the inner wall of the inner sleeve 42 and causes it to fall into the middle chamber. At the same time, the rotating ring 51 also begins to scrape off the material remaining on the outer wall of the inner sleeve 42.

[0058] S8. When the lifting plate 33 rises to the fourth threshold, the inner sleeve 42 moves out from the inside of the rotating ring 51. At this time, the rotating ring 51 stops rotating. When the lifting plate 33 rises to the fifth threshold, the oil-repellent scraper 36 reaches the bottom opening of the inner sleeve 42. Subsequently, with the continued mixing of the first stirring rod 47, the progesterone vaginal gel product is obtained from the material in the middle chamber.

[0059] S9. Output the finished progesterone vaginal gel. When the lifting plate 33 rises to the sixth threshold, the lifting plate 33 moves to the top of the reciprocating thread on the outside of the drive shaft 31. As the drive shaft 31 continues to rotate, the lifting plate 33 moves down to reset.

[0060] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A method for preparing a progesterone vaginal gel, characterized in that: The preparation method of the progesterone vaginal gel is implemented using a progesterone vaginal gel preparation device, which includes a mixing vessel (1). A top plate (2) is fixedly installed on the top of the mixing vessel (1). A drive scraping mechanism (3) is provided inside the mixing vessel (1) and on the inner side of the top plate (2). An oil phase preparation mechanism (4) is provided on the outer side of the drive scraping mechanism (3). An aqueous phase preparation mechanism (5) is provided at the bottom of the outer side of the oil phase preparation mechanism (4), and a premix preparation mechanism (7) is provided on the top of the outer side of the oil phase preparation mechanism (4). A drive support mechanism (6) is provided on the outer side of the top plate (2) and the aqueous phase preparation mechanism (5). The premix preparation mechanism (7) and the drive support mechanism (6) divide the interior of the mixing vessel (1) into an upper chamber, a middle chamber, and a lower chamber. An inner chamber is formed on the inner side of the oil phase preparation mechanism (4). The drive scraping mechanism (3) includes a drive shaft (31), a drive motor (32), a lifting plate (33), a connecting pipe (34), a rotating plate (35), and an oil-repellent scraper (36); The drive shaft (31) passes through the top of the inner cavity of the mixing vessel (1) and the top plate (2), and is rotatably connected to the mixing vessel (1) and the top plate (2) through bearings. The drive motor (32) is fixedly installed at the bottom of the inner cavity of the mixing vessel (1) and is connected to the drive shaft (31) for transmission. The lifting plate (33), the connecting pipe (34), the rotating plate (35) and the oil-repellent scraper (36) are sequentially sleeved on the outside of the drive shaft (31) from top to bottom. The lifting plate (33) is connected to the drive shaft (31) through reciprocating thread transmission. One end of the connecting pipe (34) is rotatably nested at the bottom of the lifting plate (33) through bearings and the other end is rotatably nested at the top of the rotating plate (35) through bearings. The rotating plate (35) is slidably nested on the outside of the drive shaft (31) in the vertical direction. The oil-repellent scraper (36) is fixedly connected to the drive shaft (31). The oil phase preparation mechanism (4) includes an outer sleeve (41), an inner sleeve (42), a drive groove (43), a feeding groove (44), a clearance groove (45), a first magnet (46), and a first stirring rod (47); The outer sleeve (41) is slidably disposed on the top of the mixing vessel (1), and the inner sleeve (42) is slidably nested inside the outer sleeve (41) in the vertical direction. Multiple drive grooves (43) are provided, and multiple drive grooves (43) are evenly opened on the top of the outer side of the outer sleeve (41). The feeding groove (44) is opened in the middle of the outer side of the outer sleeve (41). The clearance groove (45) is opened at the bottom of the outer side of the outer sleeve (41). Two first magnets (46) are provided, and the two first magnets (46) are respectively fixedly disposed on both sides of the inner sleeve (42). Multiple first stirring rods (47) are provided, and multiple first stirring rods (47) are evenly fixedly sleeved on the bottom of the outer side of the drive shaft (31).

2. The method for preparing a progesterone vaginal gel according to claim 1, characterized in that: The aqueous phase preparation mechanism (5) includes a rotating ring (51), a second magnet (52), a first fixed ring (53), a rotating rod (54), a drive gear (55), and a second stirring rod (56).

3. The method for preparing a progesterone vaginal gel according to claim 2, characterized in that: The rotating ring (51) is slidably sleeved on the outside of the inner sleeve (42). There are two second magnets (52), which are respectively fixedly nested on both sides inside the rotating ring (51). The first fixed ring (53) is rotatably sleeved on the outside of the rotating ring (51) through a bearing and is fixedly connected to the inner wall of the mixing vessel (1). The rotating rod (54) is fixedly installed at the bottom of the rotating ring (51). The driving gear (55) is fixedly installed at the bottom end of the rotating rod (54). There are multiple second stirring rods (56), which are evenly fixed on the outside of the rotating rod (54).

4. The method for preparing a progesterone vaginal gel according to claim 3, characterized in that: The drive support mechanism (6) includes an inner plate (61), an intermediate ring (62), an outer ring (63), and an annular rack (64).

5. The method for preparing a progesterone vaginal gel according to claim 4, characterized in that: The inner plate (61) is rotatably sleeved on the bottom outside of the drive shaft (31) via a bearing. The intermediate ring (62) is rotatably sleeved on the outside of the inner plate (61) via a bearing. The rotating rod (54) passes through the intermediate ring (62) and is rotatably connected to the intermediate ring (62) via a bearing. The outer ring (63) is rotatably sleeved on the outside of the intermediate ring (62) via a bearing and is fixedly connected to the inner wall of the mixing vessel (1). The annular rack (64) is fixedly sleeved on the bottom of the outer ring (63) and meshes with the drive gear (55).

6. The method for preparing a progesterone vaginal gel according to claim 5, characterized in that: The premix preparation mechanism (7) includes an annular baffle (71), a rotating sleeve (72), a driving slider (73), a stirring plate (74), a feeding channel (75), and a second fixing ring (76).

7. The method for preparing a progesterone vaginal gel according to claim 6, characterized in that: The annular baffle (71) is slidably sleeved on the outside of the outer sleeve (41) and fixedly connected to the inner wall of the mixing vessel (1). The rotating sleeve (72) is rotatably mounted on the top of the annular baffle (71) and fits against the outer wall of the outer sleeve (41). There are two driving sliders (73), which are respectively fixedly mounted on both sides inside the rotating sleeve (72). There are multiple stirring plates (74) and multiple feeding channels (75). Multiple stirring plates (74) are evenly fixedly mounted on the bottom of the outer side of the rotating sleeve (72) and slidably fitted against the top of the annular baffle (71). Multiple feeding channels (75) are evenly opened on the bottom of the outer side of the rotating sleeve (72). Multiple stirring plates (74) and multiple feeding channels (75) are staggered. The second fixing ring (76) is rotatably sleeved on the top of the outer side of the rotating sleeve (72) through a bearing and fixedly connected to the inner wall of the mixing vessel (1).

8. The method for preparing a progesterone vaginal gel according to claim 7, characterized in that, The preparation method of the progesterone vaginal gel specifically includes the following steps: S1. Add progesterone, carbomer and polycarbofil to the upper chamber, add glycerin, sorbic acid and purified water to the middle chamber, add liquid paraffin and hydrogenated palm oil to the inner chamber through the top opening of the outer sleeve (41), and then start the drive motor (32). S2. After the drive motor (32) starts, it drives the drive shaft (31) to rotate continuously. When the drive shaft (31) rotates, it drives the lifting plate (33) to rise, and at the same time drives the rotating plate (35) to rotate. When the rotating plate (35) rotates, it drives the outer sleeve (41) and the inner sleeve (42) to rotate. The lifting plate (33) drives the outer sleeve (41) to rise outside the inner sleeve (42) through the connecting pipe (34) and the rotating plate (35). S3. When the drive shaft (31) rotates, it drives the first stirring rod (47) to mix the material in the inner chamber. When the outer sleeve (41) rotates, it drives the rotating sleeve (72) to rotate through the drive groove (43) and the drive slider (73). When the rotating sleeve (72) rotates, it drives multiple stirring plates (74) to mix the material in the upper chamber. When the inner sleeve (42) rotates, it drives the rotating ring (51) to rotate through the first magnet (46) and the second magnet (52). When the rotating ring (51) rotates, it drives the second stirring rod (56) to mix the material in the middle chamber through the rotating rod (54). S4. When the rotating rod (54) rotates around the drive shaft (31), it drives the intermediate ring (62) and the drive gear (55) to rotate synchronously. At this time, under the action of the ring rack (64), the drive gear (55) drives the rotating rod (54) to rotate, thereby causing the second stirring rod (56) to revolve around the drive shaft (31) and rotate synchronously around the rotating rod (54). S5. When the lifting plate (33) rises to the first threshold, the driving slider (73) slides from the driving groove (43) to the inside of the feeding groove (44). At this time, the rotating sleeve (72) stops rotating. Then, the material mixed inside the annular baffle (71) enters the inside of the feeding groove (44) through multiple feeding channels (75), and then slides outward along the inner wall of the feeding groove (44) and is evenly sprinkled into the material in the middle chamber. S6. When the lifting plate (33) rises to the second threshold, the bottom of the inner cavity of the outer sleeve (41) is in contact with the top of the outer side of the inner sleeve (42). As the lifting plate (33) continues to rise, the outer sleeve (41) drives the inner sleeve (42) to rise synchronously. During the rise of the inner sleeve (42), the material in the inner cavity enters the middle cavity through the bottom opening of the inner sleeve (42) and mixes with the material in the middle cavity. At this time, the first stirring rod (47) also begins to mix the material in the middle cavity. S7. When the lifting plate (33) rises to the third threshold, the grease-repellent scraper (36) enters the inner side of the inner sleeve (42). Subsequently, as the lifting plate (33) continues to rise, the grease-repellent scraper (36) begins to scrape off the material remaining on the inner wall of the inner sleeve (42) and let it fall into the middle chamber. At the same time, the rotating ring (51) also begins to scrape off the material remaining on the outer wall of the inner sleeve (42). S8. When the lifting plate (33) rises to the fourth threshold, the inner sleeve (42) moves out from the inside of the rotating ring (51). At this time, the rotating ring (51) stops rotating. When the lifting plate (33) rises to the fifth threshold, the oleophobic scraper (36) reaches the bottom opening of the inner sleeve (42). Subsequently, with the continued mixing of the first stirring rod (47), the material in the middle chamber is used to make the progesterone vaginal gel product. S9. Output the finished progesterone vaginal gel. Subsequently, when the lifting plate (33) rises a certain distance... When the sixth threshold is reached, the lifting plate (33) moves to the top of the reciprocating thread on the outside of the drive shaft (31). Subsequently, as the drive shaft (31) continues to rotate, the lifting plate (33) moves down and resets.

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