Oral care liquid compositions comprising high density solid particles and methods of suspending

Abstract

This invention provides an oral care liquid composition comprising high-density solid particles and a suspension method thereof. The composition comprises: 1) high-density solid particles, 2) a suspension system, and 3) an orally acceptable carrier; wherein the density of the solid particles is 1.2-3.9 g / cm³. 3 The viscosity of the oral care liquid composition is ≤3000 mPa·s; the suspending agent system comprises xanthan gum, gellan gum, and sodium chloride. The suspending agent system in the oral care liquid composition provided by this invention can suspend high-density solid particles (density 1.2-3.9 g / cm³). 3 It is stably and uniformly suspended in the composition formulation.

Description

Technical Field

[0001] This invention relates to the field of oral care technology, and in particular to an oral care liquid composition containing high-density solid particles and a method for stably suspending the high-density solid particles in the oral care liquid composition. Background Technology

[0002] Adding functional or decorative ingredients to personal care products is a common practice to improve consumer acceptance or user experience. One particularly attractive way to present these products is to keep the added ingredients suspended in the product formula. These products utilize suspending agents to disperse the functional or decorative ingredients evenly and stably in the product formula, thereby enhancing the efficacy of the functional ingredients or improving the product's appearance.

[0003] For example, the commercially available Kostin Cherry Blossom Shower Gel uses an acrylate copolymer as a suspending agent system to evenly distribute cherry blossom petals in the product formula, and remains stable throughout its market life.

[0004] For example, Chinese patent application CN13271921A (Example 2) discloses two oral care compositions containing petals. Compared with composition (1), composition (2) with 0.5% xanthan gum as a suspending agent can make the petals roughly evenly distributed throughout the suspended oral care composition.

[0005] For example, Chinese patent application CN113967190 discloses a suspended mouthwash. The mouthwash formula contains probiotics. To solve the problem of probiotics settling to the bottom, gellan gum and potassium nitrate are added to the formula as suspending agents.

[0006] In summary, products with suspended solid particles are common, but these products may have characteristics such as high viscosity of the product formulation or low density of suspended particles. Oral care solutions require even lower viscosity (viscosity ≤ 3000 mPa·s) to better deliver active ingredients or flow better in the oral cavity. Under these conditions, maintaining stable suspension of high-density solid particles such as mica or polymer particles in the composition remains a challenge. Summary of the Invention

[0007] The first technical problem to be solved by this invention is to provide an oral care liquid composition containing high-density solid particles. This application pertains to oral care liquid compositions with low viscosity (viscosity ≤ 3000 mPa·s) and allows for the inclusion of high-density solid particles (density 1.2-3.9 g / cm³). 3 It is uniformly suspended and stable in the composition formulation.

[0008] The second problem to be solved by the present invention is to provide a method for stably suspending high-density solid particles in an oral care liquid composition.

[0009] To solve the first technical problem mentioned above, the present invention adopts the following technical solution:

[0010] An oral care liquid composition comprising high-density solid particles, comprising:

[0011] 1) High-density solid particles,

[0012] 2) Suspension system,

[0013] 3) Oral-acceptable carriers;

[0014] in,

[0015] The density of the solid particles is 1.2-3.9 g / cm³. 3 ;

[0016] The viscosity of the oral care liquid composition is ≤3000 mPa·s;

[0017] The suspending agent system contains xanthan gum, gellan gum, and sodium chloride.

[0018] As a preferred embodiment, the suspension system further comprises methyl vinyl ether maleic anhydride copolymer (hereinafter referred to as: Gantrez).

[0019] In a preferred embodiment, the methyl vinyl ether maleic anhydride copolymer accounts for 0.3-2% of the weight of the composition.

[0020] As a preferred embodiment, the pH range of the oral care liquid composition is 5.9-9.5.

[0021] As a more preferred embodiment, the pH range of the oral care liquid composition is 7.4-8.6.

[0022] In a preferred embodiment, the oral care liquid composition includes a pH adjuster for adjusting the pH value of the composition formulation to between 5.5 and 9.5; the pH adjuster includes, but is not limited to, one or more of sodium hydroxide, hydrochloric acid, sulfuric acid, citric acid and its salts, lactic acid and its salts, phosphoric acid and its salts, phthalic acid and its salts, pyrophosphate and its salts, tripolyphosphate and its salts, polyphosphate and its salts, citric acid and its salts, and acetic acid and its salts.

[0023] In a preferred embodiment, the gellan gum accounts for 0.01-0.1% of the weight of the composition.

[0024] In a more preferred embodiment, the xanthan gum accounts for 0.01-0.1% of the weight of the composition.

[0025] In a preferred embodiment, the sodium chloride accounts for 0.2-0.8% by weight in the composition.

[0026] As a more preferred embodiment, the sodium chloride accounts for 0.2-0.6% of the weight of the composition.

[0027] In a preferred embodiment, the high-density solid particles are one or more of solid pearlescent agent particles, solid pigment particles, solid opacifier particles, and organic polymer particles.

[0028] In a more preferred embodiment, the solid pearlescent agent or solid pigment is one or more of mica, silicon dioxide, carbon powder, titanium dioxide, zinc oxide, and hydroxyapatite.

[0029] In a more preferred embodiment, the organic polymer is one or more of polylactic acid, corn starch, microcrystalline cellulose, hydroxyethyl cellulose, hydroxyethyl methyl cellulose, polymethyl methacrylate, polyglutamic acid, sodium hyaluronate, polyacrylate, fish glue, gum arabic, and paraffin oil.

[0030] In a preferred embodiment, the high-density solid particles account for 0.05-0.5% of the weight of the composition.

[0031] In a preferred embodiment, the oral care liquid composition is liquid toothpaste or mouthwash.

[0032] To address the second technical problem mentioned above, the present invention provides a method for suspending high-density solid particles in an oral care liquid composition: using xanthan gum, gellan gum, and sodium chloride as a suspending agent system.

[0033] Unless otherwise specified, all raw materials used in this invention can be obtained commercially, and the equipment used in this invention can be conventional equipment in the relevant field or refer to existing technology in the relevant field.

[0034] Beneficial effects of the present invention

[0035] Compared with the prior art, the present invention provides an oral care liquid composition comprising a specific suspending agent system, wherein the suspending agent system in the oral care liquid composition can suspend high-density solid particles (density of 1.2-3.9 g / cm³). 3 It is stably and uniformly suspended in the composition formulation. Detailed Implementation

[0036] To more clearly illustrate the present invention, the following description, in conjunction with preferred embodiments, further clarifies the invention. Those skilled in the art should understand that the specific descriptions below are illustrative rather than restrictive, and should not be construed as limiting the scope of protection of the present invention.

[0037] Unless otherwise stated, all percentages and ratios used herein are based on the total weight of the composition. Unless otherwise stated, all percentages, proportions, and contents of ingredients mentioned herein are based on the actual content of the ingredient and do not include solvents, fillers, or other substances that can be combined with these ingredients in commercially available products.

[0038] The term "includes / contains" in this article refers to other steps and components that may be added without affecting the final result.

[0039] The term "preferred" and its variations herein refer to embodiments of the invention that provide specific beneficial effects under particular conditions. However, other embodiments may also be preferred under the same or other conditions. Furthermore, the detailed description of one or more preferred embodiments does not imply that other embodiments are useless, nor is it intended to exclude other embodiments from the scope of the invention.

[0040] Unless otherwise specified in the embodiments of the present invention, the conditions shall be performed in accordance with conventional conditions or conditions recommended by the manufacturer; if the manufacturers of the reagents or instruments used are not specified, they are all conventional products that can be purchased commercially.

[0041] As one aspect of the present invention, an oral care liquid composition comprising high-density solid particles is provided, comprising:

[0042] 1) High-density solid particles,

[0043] 2) Suspension system,

[0044] 3) Oral-acceptable carriers;

[0045] in,

[0046] The density of the solid particles is 1.2-3.9 g / cm³. 3 ;

[0047] The viscosity of the oral care liquid composition is ≤3000 mPa·s;

[0048] The suspending agent system contains xanthan gum, gellan gum, and sodium chloride.

[0049] In this invention, the term "oral care liquid composition" refers to an oral care liquid composition with a viscosity ≤3000 mPa·s. Those skilled in the art understand that for compositions with very high viscosity, such as colloidal compositions like toothpaste, jelly, and shower gel (viscosity typically >20000 mPa·s), high-density solid particles can be easily and stably suspended. However, achieving stable suspension of high-density solid particles in oral care liquid compositions with a viscosity ≤3000 mPa·s presents a significant challenge. The inventive concept of this application is to achieve stable suspension of high-density solid particles in oral care liquid compositions with a viscosity ≤3000 mPa·s.

[0050] High-density solid particles

[0051] High-density solid particles are organic solids, inorganic solids, or mixtures of both, existing in any form and used in oral care compositions for decorative purposes or as a delivery of active ingredients. High-density solid particles exist in a non-dissolved form in oral care composition formulations.

[0052] In some embodiments, the density of the high-density solid particles ranges from 1.2 to 3.9 g / cm³. 3 For example, but not limited to, 1.2-3.5 g / cm³ 3 1.2-3 g / cm 3 1.2-2.5 g / cm³ 3 1.2-2.0 g / cm³ 3 1.2-1.5 g / cm³ 3 1.5-3.9 g / cm³ 3 1.5-3.5g / cm 3 1.5-3g / cm 3 1.5-2.5g / cm 3 1.5-2.0 g / cm³ 3 2.0-3.9 g / cm³, 2.0-3.5 g / cm³ 3 2.0-3g / cm 3 2.0-2.5 g / cm³ 3 2.5-3.9 g / cm³ 3 2.5-3.5 g / cm³ 3 2.5-3g / cm 3 .

[0053] In some embodiments, the high-density solid particles constitute 0.05-0.5% of the composition by mass, for example, but not limited to, 0.05-0.45%, 0.05-0.4%, 0.05-0.35%, 0.05-0.3%, 0.05-0.25%, 0.05-0.2%, 0.05-0.15%, 0.05-0.1%, 0.1-0.5%, 0.1-0.45%, 0.1-0.4%, 0.1-0.35%, 0.1-0.3%, 0.1-0.25%, 0.1-0.2%, 0.1-0.15%, 0.15-0.5%, 0.15-0.45%, 0.15-0.4%, 0.15-0. 35%, 0.15-0.3%, 0.15-0.25%, 0.15-0.2%, 0.2-0.5%, 0.2-0.45%, 0.2-0.4%, 0.2-0.35%, 0.2-0.3%, 0.2-0.25%, 0.25-0.5%, 0.25-0.45%, 0.25-0.4%, 0.25-0.35%, 0.25-0.3%, 0.3-0.5%, 0.3-0.45%, 0.35-0.45%, 0.35-0.4%, 0.4-0.5%, 0.4-0.45%, 0.45-0.5%.

[0054] In some embodiments, the high-density solid particles are one or more of solid pearlescent agent particles, solid pigment particles, solid opacifier particles, and organic polymer particles.

[0055] In some preferred embodiments, the solid pearlescent agent or solid pigment is one or more of mica, silicon dioxide, carbon powder, titanium dioxide, zinc oxide, and hydroxyapatite.

[0056] In some preferred embodiments, the organic polymer is one or more of polylactic acid, corn starch, microcrystalline cellulose, hydroxyethyl cellulose, hydroxyethyl methyl cellulose, polymethyl methacrylate, polyglutamic acid, sodium hyaluronate, polyacrylate, fish glue, gum arabic, and paraffin oil.

[0057] Gel

[0058] Gellan gum is an aqueous colloidal polysaccharide produced by the aerobic fermentation of carbohydrates by microorganisms, including *Sphingomonas elodea* and *Pseudomonas elodea*. Its molecular structure is a linear chain based on repeating D-glucose, D-glucuronic acid, and L-rhamnose units. In its natural state, gellan gum is highly acylated. Gellan gum is commercially available.

[0059] In some embodiments, the gellan gum is a low-acylated gellan gum that has at least partially deacylated.

[0060] In some embodiments, the gellan gum is present in the oral care liquid composition at a weight ratio of 0.01-0.1%, such as, but not limited to, 0.02-0.1%, 0.025-0.1%, 0.03-0.1%, 0.04-0.1%, 0.05-0.1%, 0.06-0.1%, 0.07-0.1%, 0.075-0.1%, 0.08-0.1%, 0.09-0.1%, 0.01-0.09%, 0.02-0.09%, 0.025-0.09%, 0.03-0.09%, 0.04-0.09%. %, 0.05-0.09%, 0.06-0.09%, 0.07-0.09%, 0.075-0.09%, 0.01-0.08%, 0.02-0.08%, 0.025-0.08%, 0.03-0.08%, 0.04-0.08%, 0.05-0.08%, 0.06-0.08%, 0.07-0.08%, 0.075-0.08%, 0.01-0.075%, 0.02-0.075%, 0.025-0.075%, 0.03-0.075%, 0.04 -0.075%, 0.05-0.075%, 0.06-0.075%, 0.07-0.075%, 0.01-0.06%, 0.02-0.06%, 0.025-0.06%, 0.03-0.06%, 0.04-0.06%, 0.05-0.06%, 0.01-0.06%, 0.02-0.06%, 0.025-0.06%, 0.03-0.06%, 0.04-0.06%, 0.05-0.06%, 0.01-0.05%, 0.02-0.05%, 0 0.025-0.05%, 0.03-0.05%, 0.04-0.05%, 0.05-0.05%, 0.01-0.05%, 0.02-0.05%, 0.025-0.05%, 0.03-0.05%, 0.04-0.05%, 0.01-0.04%, 0.02-0.04%, 0.025-0.04%, 0.03-0.04%, 0.01-0.03%, 0.02-0.03%, 0.025-0.03%, 0.01-0.025%, 0.01-0.02%.

[0061] Xanthan Gum

[0062] Xanthan gum has a primary structure composed of regular repeating units, each containing five sugars: two glucose units, two mannose units, and one glucuronic acid unit. The main chain is constructed from β-D-glucose units linked at positions 1 and 4, meaning its chemical structure is identical to cellulose. A trisaccharide side chain is attached at position 3 of every other glucose residue in the main chain. Approximately half of the terminal D-mannose residues contain pyruvate residues linked at positions 4 and 6.

[0063] In some embodiments, the xanthan gum is present in the oral care liquid composition at a mass percentage of 0.01-0.1%, such as, but not limited to, 0.02-0.1%, 0.025-0.1%, 0.03-0.1%, 0.04-0.1%, 0.05-0.1%, 0.06-0.1%, 0.07-0.1%, 0.075-0.1%, 0.08-0.1%, 0.09-0.1%, 0.01-0.09%, 0.02-0.09%, 0.025-0.09%, 0.03-0.09%, 0.04-0.09%. 9%, 0.05-0.09%, 0.06-0.09%, 0.07-0.09%, 0.075-0.09%, 0.01-0.08%, 0.02-0.08%, 0.025-0.08%, 0.03-0.08%, 0.04-0.08%, 0.05-0.08%, 0.06-0.08%, 0.07-0.08%, 0.075-0.08%, 0.01-0.075%, 0.02-0.075%, 0.025-0.075%, 0.03-0.075%, 0.04 -0.075%, 0.05-0.075%, 0.06-0.075%, 0.07-0.075%, 0.01-0.06%, 0.02-0.06%, 0.025-0.06%, 0.03-0.06%, 0.04-0.06%, 0.05-0.06%, 0.01-0.06%, 0.02-0.06%, 0.025-0.06%, 0.03-0.06%, 0.04-0.06%, 0.05-0.06%, 0.01-0.05%, 0.02-0.05%, 0 0.025-0.05%, 0.03-0.05%, 0.04-0.05%, 0.05-0.05%, 0.01-0.05%, 0.02-0.05%, 0.025-0.05%, 0.03-0.05%, 0.04-0.05%, 0.01-0.04%, 0.02-0.04%, 0.025-0.04%, 0.03-0.04%, 0.01-0.03%, 0.02-0.03%, 0.025-0.03%, 0.01-0.025%, 0.01-0.02%.

[0064] Sodium chloride

[0065] In the composition of the present invention, the sodium chloride accounts for 0.2-0.8% by mass, for example, but not limited to, 0.2-0.7%, 0.2-0.6%, 0.2-0.5%, 0.2-0.4%, 0.2-0.3%, 0.3-0.8%, 0.3-0.7%, 0.3-0.6%, 0.3-0.5%, 0.3-0.4%, 0.4-0.8%, 0.4-0.7%, 0.4-0.6%, 0.4-0.5%, 0.5-0.8%, 0.5-0.7%, 0.5-0.6%, 0.6-0.8%, and 0.6-0.7%.

[0066] Methyl vinyl ether maleic anhydride copolymer (abbreviation: Gantrez)

[0067] Methyl vinyl ether maleic anhydride copolymer is a copolymer formed by polymerizing maleic acid or anhydride with methyl vinyl ether. It is generally used as a bio-adhesive in oral care products, serving as a film-forming agent and extending the residence time of active ingredients on oral mucosa or tooth enamel. This application unexpectedly discovered that by adding Gantrez to the suspension system, stable suspension of high-density solid particles in oral care liquid compositions with a viscosity ≤3000 mPa·s can be achieved more effectively under high-temperature conditions (40°C).

[0068] In some embodiments, the methyl vinyl ether maleic anhydride copolymer accounts for 0.3-2% by mass in the composition, for example, but not limited to, 0.5-2%, 0.75-2%, 1-2%, 1.25-2%, 1.5-2%, 1.75-2%, 0.3-1.75%, 0.5-1.75%, 0.75-1.75%, 1-1.75%, 1.25-1.75%, 1.5-1.75%, 0.3-1.5%, 0.5-1.5%, 0.75-1.5%, 1-1.5%, 1.25-1.5%, 0.3-1.25%, 0.5-1.25%, 0.75-1.25%, 1-1.25%, 0.3-1%, 0.5-1%, 0.75-1%, 0.3-0.75%, 0.5-0.75%, and 0.3-0.5%.

[0069] Oral care solution composition viscosity

[0070] The oral care liquid composition described in this application has a viscosity of less than or equal to 3000 mPa·s, such as, but not limited to, 5-3000 mPa·s, 5-2800 mPa·s, 5-2500 mPa·s, 5-2000 mPa·s, 5-1500 mPa·s, 5-1000 mPa·s, 10-3000 mPa·s, 10-2800 mPa·s, 10-2500 mPa·s, 10-2000 mPa·s, 10-1500 mPa·s, 10-1000 mPa·s, 3 0-3000mPa.s, 30-2800mPa.s, 30-2500mPa.s, 30-2000mPa.s, 30-1500mPa.s, 30-1000mPa.s, 50-3000mPa.s, 50-2 800mPa.s, 50-2500mPa.s, 50-2000mPa.s, 50-1500mPa.s, 50-1000mPa.s, 100-3000mPa.s, 100-2800mPa.s, 100-2 500mPa.s, 100-2000mPa.s, 100-1500mPa.s, 100-1000mPa.s, ≤500mPa.s, ≤300mPa.s, ≤200mPa.s, ≤100mPa.s, ≤80 mPa.s, ≤50mPa.s, 5-100mPa.s, 10-100mPa.s, 20-100mPa.s, 30-100mPa.s, 40-100mPa.s, 50-100mPa.s, 80-100mP a.s, 5-80mPa.s, 10-80mPa.s, 20-80mPa.s, 30-80mPa.s, 40-80mPa.s, 50-80mPa.s, 5-50mPa.s, 10-50mPa.s, 20-5 0mPa.s, 30-50mPa.s, 40-50mPa.s, 5-40mPa.s, 10-40mPa.s, 20-40mPa.s, 30-40mPa.s, 10-30mPa.s, 20-30mPa.s.

[0071] pH

[0072] This application unexpectedly discovered that when the pH value in the oral care liquid composition is stable between 5.5 and 9.5, the suspension stability of high-density solid particles in the composition formulation can be improved.

[0073] In some embodiments, the pH value of the oral care liquid composition is 5.5-9.5, such as, but not limited to, 5.9-9.5, 6.3-9.5, 7-9.5, 7.4-9.5, 8.1-9.5, 8.6-9.5, 6.3-9.5, 9-9.5, 5.5-9, 5.9-9, 6.3-9, 7-9, 7.4-9, 8.1-9, 8.6-9, 5.5-8.6, 5 .9-8.6, 6.3-8.6, 7-8.6, 7.4-8.6, 8.1-8.6, 5.5-8.1, 5.9-8.1, 6.3-8.1, 7-8.1, 7.4-8.1, 5.5-7.4, 5.9-7.4, 6.3-7.4, 7-7.4, 5.5-7, 5.9-7, 6.3-7, 5.5-6.3, 5.9-6.3, 5.5-5.9.

[0074] In some embodiments, the oral care liquid composition includes a pH adjuster for adjusting the pH of the composition formulation to between 5.5 and 9.5.

[0075] In some embodiments, the pH adjuster includes, but is not limited to, one or more of sodium hydroxide, hydrochloric acid, sulfuric acid, citric acid and its salts, lactic acid and its salts, phosphoric acid and its salts, phthalic acid and its salts, pyrophosphate and its salts, tripolyphosphate and its salts, polyphosphate and its salts, citric acid and its salts, and acetic acid and its salts.

[0076] Other oral acceptable carriers

[0077] In this invention, "orally acceptable carrier" refers to any medium suitable for formulating the oral care liquid compositions disclosed herein; an orally acceptable carrier is harmless to mammals when held in the mouth in the amount disclosed herein without being swallowed for a duration sufficient to allow effective contact with the tooth surface as required by the invention; generally, an orally acceptable carrier is not harmful even if unintentionally swallowed; suitable orally acceptable carriers include, for example, one or more of the following substances: water, thickeners, pH adjusters, humectants, sweeteners, flavorings, visual aids (e.g., pigments, dyes or mixtures thereof), anti-caries agents, antibacterial agents, whitening agents, desensitizing agents, vitamins, preservatives, enzymes and mixtures thereof.

[0078] In some embodiments of the present invention, the oral care liquid composition is liquid toothpaste, mouth spray, or mouthwash.

[0079] Method for detecting the viscosity of oral care liquid composition of the present invention

[0080] 1. Select model DV2TRV viscometer;

[0081] 2. Adjust the viscometer holder to keep the viscometer horizontal;

[0082] 3. Turn on the viscometer power. The viscometer display will prompt you to perform a zeroing operation (the rotor must not be connected during the zeroing process). Press Next to perform the zeroing; set the rotor speed to 2000 revolutions per second.

[0083] 4. Adjust the sample position so that the rotor is directly in the center of the sample. Press down the lifting pin on the lifting bracket, turn on the power to the lifting bracket, and the lifting bracket will begin to descend automatically; when the rotor contacts the toothpaste sample surface, click the run button to start the test; after the test is complete, turn off the power to the lifting bracket and click save. Specific Implementation

[0085] In this application, the formulations of the embodiments and comparative examples all include Basic Formula , Suspension system and Deionized water .

[0086] Basic Recipe 1

[0087] Basic formula 1 contains the ingredients listed in Table 1:

[0088] Table 1

[0089]

[0090] Suspension system 1

[0091] The suspension system comprises the components listed in Table 2:

[0092] Table 2

[0093] Amount added (by weight percentage) acrylate copolymer 2

[0094] Comparative Examples 1-1 to 1-4

[0095] Comparative Examples 1-1 to 1-4 consist of a basic formulation 1, a suspension system 1, 0.1 wt% solid particles, and deionized water added to 100%.

[0096] Add solid particles to the comparative examples according to Table 3:

[0097] Table 3:

[0098] Comparative Example 1-1 Comparative Examples 1-2 Comparative Examples 1-3 Comparative Examples 1-4 Solid particles 1 0.1 / / / Solid particles 2 / 0.1 / / Solid particles 3 / / 0.1 / Solid particles 4 / / / 0.1 observe Floating Floating Floating Floating

[0099] Note:

[0100] Solid particle 1 has a density of 3.5 g / cm³. 3 mica powder particles;

[0101] Solid particle 2 has a density of 1.2 g / cm³. 3 polymer particles;

[0102] Solid particle 3 has a density of 0.20 g / cm³. 3 Plant petal particles;

[0103] Solid particle 4 has a density of 0.25 g / cm³. 3 Longjing tea granules.

[0104] The pH values ​​of Comparative Examples 1-1 to 1-4 were 7.9. After being placed at room temperature for 12 hours, Comparative Examples 1-1 to 1-4 exhibited the following appearance:

[0105] Table 4:

[0106] Comparative Example 1-1 Comparative Examples 1-2 Comparative Examples 1-3 Comparative Examples 1-4 Particle state Floating Floating Floating Floating

[0107] As shown in Tables 2-4, Comparative Examples 1-1 to 1-4, referencing the Kostin Cherry Blossom Shower Gel, used acrylate copolymer as the suspending agent system, with an addition amount of 2% acrylate copolymer. At this point, the viscosity of the composition was 27400 mPa·s. After standing at room temperature for 12 hours, the solid particles in all four formulations of Comparative Examples 1-1 to 1-4 remained in a suspended state. This means that in a high-viscosity colloidal composition, almost all solid particles can be stably suspended within it.

[0108] Suspension system 2

[0109] Suspension system 2 comprises the components listed in Table 5 below:

[0110] Table 5

[0111] Amount added (by weight percentage) acrylate copolymer 0.05

[0112] Comparative Examples 2-1 to 2-4

[0113] Comparative Examples 2-1 to 2-4 consist of a basic formulation 1, a suspending agent system 2, 0.1% solid particles, and deionized water added to bring the total to 100%.

[0114] Add solid particles to the comparative examples according to Table 6 below.

[0115] Table 6

[0116] Comparative Example 2-1 Comparative Example 2-2 Comparative Examples 2-3 Comparative Examples 2-4 Solid particles 1 0.1 / / / Solid particles 2 / 0.1 / / Solid particles 3 / / 0.1 / Solid particles 4 / / / 0.1

[0117] The viscosity of Comparative Examples 2-1 to 2-4 was 31 mPa·s, and the pH value was 7.9. After being left at room temperature for 12 hours, the appearance of Comparative Examples 2-1 to 2-4 was as shown in Table 7 below:

[0118] Table 7

[0119] Comparative Example 2-1 Comparative Example 2-2 Comparative Examples 2-3 Comparative Examples 2-4 Particle state precipitation precipitation Floating Floating

[0120] As can be seen from Tables 5-7:

[0121] Comparative Examples 2-1 to 2-4 also used acrylate copolymers as the suspension system, but the amount of acrylate copolymer added was 0.05%. At this time, the viscosity of the composition was only 31 mPa.s, which is consistent with the viscosity of commonly used oral care solution compositions.

[0122] After comparative examples 2-1 to 2-4 were left at room temperature for 12 hours, the solid particles in the formulations of comparative examples 2-3 and 2-4 remained in suspension, but the solid particles in the formulations of comparative examples 2-1 and 2-2 had precipitated.

[0123] In other words, in low-viscosity liquid formulations, high-density solid particles settle more easily than low-density solid particles.

[0124] Suspension system 3

[0125] The suspending agent system 3 contains the components listed in Table 8 below.

[0126] Table 8:

[0127] Amount added (by weight percentage) Xanthan Gum 0.5

[0128] Comparative Examples 3-1 to 3-4

[0129] Comparative Examples 3-1 to 3-4 consist of basic formulation 1, suspension system 3, 0.1% solid particles, and deionized water added to 100%.

[0130] Add solid particles to the comparative examples according to Table 9 below.

[0131] Table 9

[0132] Comparative Example 3-1 Comparative Example 3-2 Comparative Example 3-3 Comparative Examples 3-4 Solid particles 1 0.1 / / / Solid particles 2 / 0.1 / / Solid particles 3 / / 0.1 / Solid particles 4 / / / 0.1

[0133] Comparative Examples 3-1 to 3-4 had a viscosity of 2832 mPa·s and a pH of 7.9. After being left at room temperature for 12 hours, the appearance of Comparative Examples 3-1 to 3-4 was as follows:

[0134] Table 10

[0135] Comparative Example 2-1 Comparative Example 2-2 Comparative Examples 2-3 Comparative Examples 2-4 Particle state precipitation precipitation Floating Floating

[0136] As can be seen from Tables 8-10:

[0137] Comparative Examples 3-1 to 3-4 used 0.5% xanthan gum as a suspension system, and the viscosity of the composition was 2832 mPa·s, which is consistent with the viscosity of commonly used oral care solution compositions.

[0138] After comparative examples 3-1 to 3-4 were left at room temperature for 12 hours, the solid particles in the formulations of comparative examples 3-3 and 3-4 remained in suspension, but the solid particles in the formulations of comparative examples 3-1 and 3-2 had precipitated.

[0139] In other words, in a low-viscosity liquid formulation using 0.5 wt% xanthan gum as a suspending agent, high-density solid particles cannot maintain stable suspension.

[0140] Suspension system 4

[0141] The suspending agent system comprises the components listed in Table 11.

[0142] Table 11

[0143] Amount added (by weight percentage) Gel 0.05 potassium nitrate 0.5

[0144] Comparative Examples 4-1 to 4-4

[0145] Comparative Examples 4-1 to 4-4 consist of basic formulation 1, suspension system 4, 0.1% solid particles, and deionized water added to 100%.

[0146] Add solid particles to the comparative examples according to Table 12 below:

[0147] Table 12

[0148] Comparative Example 4-1 Comparative Example 4-2 Comparative Example 4-3 Comparative Example 4-4 Solid particles 1 0.1 / / / Solid particles 2 / 0.1 / / Solid particles 3 / / 0.1 / Solid particles 4 / / / 0.1

[0149] The viscosity of Comparative Examples 4-1 to 3-4 was 32.6 mPa·s, and the pH value was 7.9. After being placed at room temperature for 12 hours, the appearance of Comparative Examples 4-1 to 4-4 was as follows:

[0150] Table 13

[0151] Comparative Example 4-1 Comparative Example 4-2 Comparative Example 4-3 Comparative Example 4-4 Particle state precipitation precipitation Floating Floating

[0152] As can be seen from Tables 11-13:

[0153] Comparative Examples 4-1 to 4-4 used 0.05% gellan gum and 0.5% potassium nitrate as suspension systems. The viscosity of the composition was only 32.6 mPa·s, which is consistent with the viscosity of commonly used oral care solution compositions.

[0154] After comparative examples 4-1 to 4-4 were left at room temperature for 12 hours, the solid particles in the formulations of comparative examples 4-3 and 4-4 remained in suspension, but the solid particles in the formulations of comparative examples 4-1 and 4-2 had precipitated.

[0155] In other words, in a low-viscosity liquid formulation using a system of 0.05% gellan gum and 0.5% potassium nitrate as suspending agents, high-density solid particles cannot maintain stable suspension.

[0156] Comparative Examples 5-6, Comparative Examples 7-1 to 7-3, Examples 1-2

[0157] Comparative Examples 5-6, 7-1 to 7-3, and Examples 1-2 were prepared according to Table 14 below; all components in Table 14 are by weight percentage.

[0158] Table 14

[0159]

[0160] As can be seen from Table 14:

[0161] The suspension system of Comparative Example 5 contained 0.05% gellan gum and 0.5% sodium chloride;

[0162] The suspension system of Comparative Example 6 contained 0.05% xanthan gum and 0.5% sodium chloride;

[0163] The suspension system of Example 1 contains 0.025% gellan gum, 0.025% xanthan gum and 0.5% sodium chloride;

[0164] The suspension system of Example 2 contains 0.025% gellan gum, 0.025% xanthan gum, 0.5% sodium chloride and 0.5% Gantrez;

[0165] The suspending agent system of Comparative Example 7-1 contains 0.025% gellan gum, 0.025% xanthan gum, 0.5% potassium nitrate and 0.5% Gantrez;

[0166] The suspension system of Comparative Example 7-2 contains 0.025% gellan gum, 0.025% xanthan gum, 0.5% sodium nitrate and 0.5% Gantrez;

[0167] The suspending agent system of Comparative Example 7-3 contains 0.025% gellan gum, 0.025% xanthan gum, 0.5% potassium chloride and 0.5% Gantrez.

[0168] The appearance of Comparative Examples 5-6, 7-1 to 7-3, and Examples 1-2 after being placed at room temperature for 12 hours, at room temperature for 90 days, and at 40°C for 90 days were observed. The results are shown in Table 15.

[0169] Table 15

[0170]

[0171] As can be seen from Table 15:

[0172] Comparative Example 5, which uses 0.05% gellan gum and 0.5% sodium chloride as suspending agents, showed that the solid particles were in suspension after 12 hours of standing, but began to settle after 90 days at room temperature.

[0173] Comparative Example 6, which used 0.05% xanthan gum and 0.5% sodium chloride as suspending agents, began to settle after 12 hours.

[0174] In Example 1, which uses 0.025% gellan gum, 0.025% xanthan gum and 0.5% sodium chloride as a suspending agent, the solid particles remained suspended after being placed at room temperature for 90 days. However, after being placed at 40°C for 90 days, the solid particles began to settle.

[0175] In Example 2, which used a suspension system of 0.025% gellan gum, 0.025% xanthan gum, 0.5% sodium chloride and 0.5% Gantrez, the solid particles remained suspended after being placed at 40°C for 90 days.

[0176] Comparative Example 7-1, which uses 0.025% gellan gum, 0.025% xanthan gum, 0.5% potassium nitrate and 0.5% Gantrez as suspending agents, showed that the solid particles had begun to settle after being left at room temperature for 12 hours.

[0177] Comparative Example 7-2, which used 0.025% gellan gum, 0.025% xanthan gum, 0.5% sodium nitrate and 0.5% Gantrez as suspending agents, showed that the solid particles had begun to settle after being left at room temperature for 12 hours.

[0178] Comparative Example 7-3, which used 0.025% gellan gum, 0.025% xanthan gum, 0.5% potassium chloride and 0.5% Gantrez as suspending agents, also showed that the solid particles began to settle after being left at room temperature for 12 hours.

[0179] In summary, a suspending agent system containing gellan gum, xanthan gum, and sodium chloride can maintain the suspension of high-density solid particles at room temperature for extended periods. Adding Gantrez to a suspending agent system based on gellan gum, xanthan gum, and sodium chloride allows the high-density particles to remain suspended at high temperatures (40°C) for a longer period. However, replacing sodium chloride with monovalent inorganic salts such as potassium nitrate, sodium nitrate, and potassium chloride cannot maintain the stable suspension of high-density solid particles in oral care liquid compositions for extended periods.

[0180] Examples 3-5

[0181] Examples 3-5 were prepared according to Table 16 below; all components in Table 16 are expressed as weight percentages.

[0182] Table 16

[0183]

[0184] As can be seen from Table 16:

[0185] Examples 3-5 all used gellan gum, xanthan gum, sodium chloride, and Gantrez as suspending agents, with the addition amount of gellan gum being 0.025%, xanthan gum being 0.025%, and Gantrez being 0.5%. Specifically, the addition amount of sodium chloride in Example 3 was 0.2%, in Example 4 it was 0.6%, and in Example 5 it was 0.8%.

[0186] The appearance of Examples 3-5 after being placed at room temperature for 12 hours, at room temperature for 90 days, and at 40°C for 90 days was observed. The results are shown in Table 17.

[0187] Table 17

[0188] Example 3 Example 4 Example 5 12 hours Floating Floating Floating 90 days at room temperature Floating Floating Floating 40℃ for 90 days Floating Floating settlement

[0189] As can be seen from Table 17:

[0190] When the amount of sodium chloride added is 0.2% or 0.6%, the solid particles remain suspended after being placed at 40°C for 90 days; however, when the concentration of sodium chloride is increased to 0.8%, the solid particles actually settle after being placed at 40°C for 90 days.

[0191] Example 6

[0192] Example 6 was prepared according to Table 18. For ease of comparison, Example 2 is included in Table 18:

[0193] Table 18

[0194]

[0195] As can be seen from Table 18:

[0196] Example 6 uses a suspension system of 0.03% gellan gum, 0.025% xanthan gum and 0.5% sodium chloride, and its viscosity is comparable to that of Example 2.

[0197] The appearance of Example 6 after being placed at room temperature for 12 hours, at room temperature for 90 days, and at 40°C for 90 days was observed. The results are shown in Table 19.

[0198] Table 19

[0199] Example 6 Example 2 12 hours Floating Floating 90 days at room temperature Floating Floating 40℃ for 90 days settlement Floating

[0200] As can be seen from Table 19:

[0201] Although the viscosities of Example 6 and Example 2 are similar, after being placed at 40°C for 90 days, the solid particles of Example 6 without the addition of Gantrez showed sedimentation.

[0202] Examples 7-8

[0203] Prepare Examples 7-8 according to Table 20.

[0204] Table 20

[0205]

[0206] As can be seen from Table 20:

[0207] Example 7 uses 0.01% gellan gum, 0.01% xanthan gum and 0.5% sodium chloride as a suspending agent system, and its formulation viscosity is 5 mPa·s; Example 8 uses 0.1% gellan gum, 0.1% xanthan gum and 0.5% sodium chloride as a suspending agent system, and its formulation viscosity is 52 mPa·s.

[0208] The appearance of Examples 7-8 after being placed at room temperature for 12 hours, at room temperature for 90 days, and at 40°C for 90 days was observed, and the results are shown in Table 21:

[0209] Table 21

[0210] Example 7 Example 8 12 hours Floating Floating 90 days at room temperature Floating Floating 40℃ for 90 days Floating Floating

[0211] As can be seen from Table 21, after being placed at 40°C for 90 days, the solid particles in Examples 7 and 8 were in a suspended state.

[0212] Basic Recipe 2

[0213] Basic formula 2 contains the ingredients listed in Table 2.

[0214] Table 22

[0215]

[0216] Comparative Example 8, Examples 9-16

[0217] Comparative Examples 8 and Examples 9-16 comprise a basic formulation 2, a pH adjuster, 0.3% solid particles 5, and deionized water to bring the total to 100%, wherein the density of the solid particles is 3.9 g / cm³. 3 .

[0218] The pH values ​​of the formulations in Comparative Example 8 and Examples 9-16 are shown in Table 23 below:

[0219] Table 23:

[0220]

[0221] The appearance of Comparative Example 8 and Examples 9-16 was observed after being placed at room temperature for 12 hours, at room temperature for 90 days, and at 40°C for 90 days, respectively. The results are shown in Table 24 below:

[0222] Table 24

[0223]

[0224] As can be seen from Table 24:

[0225] After being placed at room temperature for 12 hours, the solid particles in Comparative Example 8 and Examples 7-16 were in a suspended state; however, after being placed at room temperature for 90 days, the solid particles in the formulation of Comparative Example 8 with a pH of 5.5 had settled; after being placed at 40°C for 90 days, only the solid particles in the formulations of Examples 12 to 14 remained in a suspended state.

[0226] In other words, when using the same suspending agent system, the pH value in the oral care liquid composition also has a certain impact on the suspension stability of solid particles.

[0227] Obviously, the above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the implementation of the present invention. Those skilled in the art can make other variations or modifications based on the above description. It is impossible to exhaustively list all embodiments here. All obvious variations or modifications derived from the technical solutions of the present invention are still within the protection scope of the present invention.

Claims

1. An oral care liquid composition comprising high density solid particles characterised in that, Comprising: 1) high density solid particles, 2) a suspending agent system, 3) an orally acceptable carrier; wherein, The high-density solid particles have a density of 1.2-3.9 g / cm 3 ; the oral care liquid composition has a viscosity of < 3000 mPa.s; the suspending agent system comprises xanthan gum, gellan gum, sodium chloride, and a methyl vinyl ether maleic anhydride copolymer; the methyl vinyl ether maleic anhydride copolymer is present in the composition in an amount of 0.3-2% by weight; the gellan gum is present in the composition in an amount of 0.01-0.1% by weight; the xanthan gum is present in the composition in an amount of 0.01-0.1% by weight; the sodium chloride is present in the composition in an amount of 0.2-0.6% by weight; the high density solid particles are present in the composition in an amount of 0.1-0.3% by weight; the oral care liquid composition has a pH of 7.4-8.

6.

2. An oral care liquid composition comprising high density solid particles according to claim 1 characterised in that: the oral care liquid composition comprises a pH adjusting agent for adjusting the pH of the composition formulation to between 5.5-9.5; the pH adjusting agent includes, but is not limited to, one or more of sodium hydroxide, hydrochloric acid, sulfuric acid, citric acid and its salts, lactic acid and its salts, phosphoric acid and its salts, phthalic acid and its salts, pyrophosphoric acid and its salts, tripolyphosphoric acid and its salts, polyphosphoric acid and its salts, citric acid and its salts, acetic acid and its salts.

3. An oral care liquid composition comprising high density solid particles according to claim 1 characterised in that: the high density solid particles are one or more of solid pearlescent particles, solid pigment particles, solid opacifier particles, organic polymeric particles.

4. An oral care liquid composition comprising high density solid particles according to claim 3 characterised in that: the solid pearlescent or solid pigment is one or more of mica, silica, carbon powder, titanium dioxide, zinc oxide, hydroxyapatite.

5. An oral care liquid composition comprising high density solid particles according to claim 3 characterised in that: the organic polymeric is one or more of polylactic acid, corn starch, microcrystalline cellulose, hydroxyethyl cellulose, hydroxyethyl methyl cellulose, polymethyl methacrylate, polyglutamic acid, sodium hyaluronate, polyacrylate, fish gelatin, gum arabic, paraffin oil.

6. An oral care liquid composition comprising high density solid particles according to claim 1 characterised in that: the oral care liquid composition is a liquid toothpaste, mouth spray, or mouthwash.

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