A mouse muscle strength testing device and method

Abstract

The application discloses a mouse muscle strength testing device and method, and belongs to the technical field of animal physiology function detection; the device comprises a box body, a turnover assembly, a lifting assembly and a force measuring assembly; the box body comprises a plurality of testing chambers which are spaced apart from each other; the turnover assembly comprises grid plates which can be turned by 180 degrees and rotating members; the grid plates are arranged in the testing chambers respectively; each grid plate is rotationally connected with the box body through a rotating member; the lifting assembly is arranged opposite to the grid plate; the lifting assembly comprises mouse clothes for binding mice and a pulling member capable of adjusting the pulling force; the pulling member is vertically arranged and fixedly connected with the mouse clothes; the force measuring assembly comprises a force measuring matrix; the force measuring matrix is arranged between the rotating member and the box body; the force measuring matrix can measure the force change of the rotating member; and the force measuring matrix is electrically connected with a processor and a timer. The gravity type sensing system can be used for studying the muscle strength of mice under different pulling forces.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of animal physiological function detection, and in particular to a mouse muscle strength testing device and method. BACKGROUND

[0002] Muscles (skeletal muscles) are the power part of the motor system, contract rapidly and powerfully to pull bones to produce movement. There are many known muscle-related diseases, such as Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, etc. These diseases are all motor-related neurodegenerative diseases. The most common pathological manifestation of various myopathies is muscle weakness, which leads to impaired motor function. Therefore, muscle strength testing has become the most basic experimental project in the study of muscle-related diseases. Mice are the main models for studying Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, etc. By detecting the state and strength of the mouse limbs during exercise, it can better help research these motor-related diseases.

[0003] However, the current experiment lacks professional equipment to realize automatic turning and timing alarm, and needs two people to cooperate to operate. At the same time, since the animals in different treatment groups persist for several minutes to several hours in the turning net experiment, the experimenters need to monitor at all times, which seriously consumes manpower and time. Therefore, it is urgent to overcome the defects of the prior art in the technical field. SUMMARY

[0004] Therefore, it is necessary to provide a mouse muscle strength testing device and method to solve the problem of complex and time-consuming process of mouse muscle strength testing.

[0005] In a first aspect, the present application provides a mouse muscle strength testing device, comprising:

[0006] a box body, the box body comprising a plurality of test chambers spaced apart from each other;

[0007] a turning assembly, the turning assembly comprising a grid plate that can be turned by 180° and a rotating member, a plurality of the grid plates being respectively arranged in a plurality of the test chambers, and each of the grid plates being rotatably connected to the box body by a rotating member;

[0008] a lifting assembly, the lifting assembly being arranged opposite to the grid plate, the lifting assembly comprising a mouse coat for binding the mouse and a traction member with adjustable traction force, the traction member being vertically arranged and fixedly connected to the mouse coat;

[0009] a force measuring assembly, the force measuring assembly comprising a force measuring matrix, the force measuring matrix being arranged between the rotating member and the box body, the force measuring matrix being capable of measuring the force change of the rotating member, and the force measuring matrix being electrically connected to a timer through a processor.

[0010] Further, the grid plate comprises a frame body and a plate body arranged in the frame body, a plurality of through holes are arranged on the plate body, and an intermediate strip for the mouse to grip is formed between adjacent through holes.

[0011] Further, an attracting bin for storing food is arranged on the side of the plate body away from the mouse, and the attracting bin is communicated with the through holes.

[0012] Further, the turnover assembly further comprises a driving member, the output shaft of the driving member is connected with the rotating member through a universal joint.

[0013] Further, the mouse coat further comprises a constraint part for binding the waist of the mouse, and the constraint part is connected with the pulling member.

[0014] Further, the pulling assembly further comprises a pulling unit, the pulling unit comprises a guide wheel and a weight, one end of the pulling member away from the mouse coat is connected with the weight through the guide wheel, and the weight can give the pulling member a constant pulling force.

[0015] Further, the force measuring assembly further comprises an outer ring and an inner ring arranged in a nested mode, the outer ring is fixedly connected with the box body, the inner ring is sleeved on the rotating member, and the force measuring matrix is arranged between the inner ring and the outer ring.

[0016] Further, the force measuring matrix comprises at least two pressure sensors, the pressure sensors are arranged around the central axis of the inner ring and abut against the inner ring and the outer ring respectively, and the pressure sensors can measure the force in the vertical direction of the rotating member.

[0017] Further, a plurality of safety bins are arranged on the lower part of the box body, the safety bins are inserted into the test chamber to receive the falling mouse.

[0018] In the second aspect, the application provides a mouse muscle strength test method, the muscle strength of the mouse is tested by using the mouse muscle strength test device, the pulling member gives the mouse a constant force away from the grid plate in the vertical direction, the force of the mouse relative to the grid plate is changed, and the muscle strength of the mouse is tested under different forces.

[0019] Compared with the prior art, the application has the beneficial effects that:

[0020] (1) The mouse muscle strength testing device and method of the present application is provided with a force measuring assembly, which includes a force measuring matrix arranged between the rotating member and the box. The weight of the grid plate is borne by the connecting part of the box and the rotating member. The force measuring assembly arranged at the connecting part can measure the force change of the rotating member in real time, so as to obtain the specific moment when the mouse leaves the grid plate, and further obtain the time length of the muscle support of the mouse. Compared with the traditional photoelectric sensing system, the gravity sensing system is more sensitive and responds more quickly, and the position of the mouse does not need to be limited, so the use is more convenient and fast.

[0021] (2) The mouse muscle strength testing device and method of the present application is provided with a lifting assembly, which includes a mouse coat and a pulling member. The mouse coat is used to bind the mouse, and the pulling member can adjust the pulling force. The pulling member is vertically arranged and fixedly connected with the mouse coat. When the mouse leaves the grid plate, the force change of the grid plate is large, and the force measuring assembly can immediately identify and stop timing. When the mouse grips the grid plate downward, the pulling member can vertically pull the mouse upward with a constant force, so as to test the muscle strength of the mouse with a force smaller than or larger than the weight of the mouse. When the mouse grips the grid plate upward, the pulling member can vertically pull the mouse downward with a constant force, so as to test the muscle strength of the mouse with a force larger than the weight of the mouse. Further, more abundant test data can be obtained, and the muscle strength of the mouse can be researched in all aspects.

[0022] (3) The mouse muscle strength testing device and method of the present application uses the mouse muscle strength testing device to measure the muscle strength of the mouse. The pulling member gives the mouse a constant force away from the grid plate, changes the force of the mouse relative to the grid plate, and tests the time length of the muscle strength grip of the mouse with different forces. Therefore, the gripping time length of the mouse on the grid plate in the comparative experiment can be adjusted as needed, so that the test data of other drugs can be changed in gradient with the change of the experimental variable, and the test of different drugs is more real and accurate. BRIEF DESCRIPTION OF DRAWINGS

[0023] The drawings described herein are used to provide further understanding of the present application, constitute a part of the present application, and the illustrative embodiments of the present application and the description thereof are used to explain the present application, and do not constitute an improper limitation on the present application. In the drawings:

[0024] Figure 1 It is a schematic view of the overall structure of the present application;

[0025] Figure 2 It is a schematic view of the side structure of the present application;

[0026] Figure 3 It is a schematic view of the structure of one side of the grid plate in the present application;

[0027] Figure 4is a structural schematic view of the other side of the grid plate in the present application;

[0028] Figure 5 is a structural schematic view of the turnover assembly in the present application;

[0029] Figure 6 is a structural schematic view of the force measuring assembly in the present application.

[0030] In the figure, the box body 100, the test chamber 110, the safety compartment 120, the turnover assembly 200, the grid plate 210, the frame body 211, the plate body 212, the mesh 212a, the intermediate strip 212b, the bait compartment 212c, the rotating member 220, the driving member 230, the universal coupling 240, the pulling assembly 300, the mouse coat 310, the pulling member 320, the pulling unit 330, the guide wheel 331, the weight 332, the force measuring assembly 400, the force measuring matrix 410, the pressure sensor 411, the outer ring 420, and the inner ring 430. DETAILED DESCRIPTION

[0031] The preferred embodiments of the present application will be described in detail below with reference to the drawings, which form a part of this application. The drawings and the associated descriptions are provided to illustrate the preferred embodiments of the present application and to explain the principles of the present application, but are not intended to limit the scope of the present application.

[0032] The mouse muscle strength testing device and method in the present embodiment relate to the field of animal physiological function detection technology. The existing mouse muscle strength testing device usually uses an infrared sensing system to determine the time when the mouse grabs the turnover plate. The testing device in the present application uses a gravity type sensing system to determine the gripping time of the mouse on the turnover plate by monitoring the gravity change of the grid plate 210, so as to obtain the muscle strength data of the mouse.

[0033] Please refer to Figures 1 to 6 The mouse muscle strength testing device in the present embodiment includes a box body 100, a turnover assembly 200, a pulling assembly 300, and a force measuring assembly 400. The box body 100 includes a plurality of test chambers 110 that are spaced apart from each other. The test chambers 110 are separated by partitions. Each test chamber 110 can be used to test the muscle strength of a mouse. Multiple comparative experiments can be performed to eliminate unexpected factors and obtain more accurate test results.

[0034] The turnover assembly 200 comprises a grid plate 210 and a rotating member 220, the grid plate 210 can be turned over by 180 degrees, so as to turn over the mouse holding the grid plate 210 by 180 degrees, so as to test the muscle strength of the mouse. A plurality of grid plates 210 are arranged in a plurality of test chambers 110, and each grid plate 210 is rotatably connected to the box 100 by a different rotating member 220. One end of the rotating member 220 is fixedly connected to the grid plate 210, and the other end of the rotating member 220 is rotatably connected to the box 100. The rotating member 220 can support the weight of the mouse and the grid plate 210 and automatically turn over the grid plate 210 by 180 degrees, thereby simplifying the experimental process and improving the experimental efficiency.

[0035] The pulling assembly 300 is arranged in the test chamber 110 and relative to the grid plate 210, and the pulling assembly 300 comprises a mouse coat 310 and a pulling member 320. The mouse coat 310 is used to bind the mouse, and the pulling member 320 can adjust the pulling force. The pulling member 320 is vertically arranged and fixedly connected to the mouse coat 310. When the mouse is separated from the grid plate 210, the grid plate 210 experiences a sharp change in force, and the force measuring assembly 400 can immediately identify and stop timing. When the mouse holds the grid plate 210 downward, the pulling member 320 can vertically pull the mouse upward with a constant force, so as to test the muscle strength of the mouse with a force less than or greater than the weight of the mouse. When the mouse holds the grid plate 210 upward, the pulling member 320 can vertically pull the mouse downward with a constant force, so as to test the muscle strength of the mouse with a force greater than the weight of the mouse. In this way, more abundant test data can be obtained, and the muscle strength of the mouse can be fully researched.

[0036] The force measuring assembly 400 comprises a force measuring matrix 410 arranged between the rotating member 220 and the box 100. All the weight of the grid plate 210 is borne by the connection between the box 100 and the rotating member 220. The force measuring assembly 400 arranged at the connection can measure the change in force of the rotating member 220 in real time, so as to obtain the specific time when the mouse is separated from the grid plate 210, and further obtain the time length during which the mouse uses the muscle to support. Compared with the traditional photoelectric sensing system, the gravity sensing system is more sensitive and responds more quickly, and does not need to limit the position of the mouse, so it is more convenient and fast to use.

[0037] The grid plate 210 has a forward position and a reverse position relative to the box 100. In the forward position, the grid plate 210 is horizontally arranged. In the reverse position, the grid plate 210 is turned over by 180 degrees relative to the forward position.

[0038] As one of the use modes, the grid plate 210 is in the forward position, the mouse is placed on the grid plate 210, the rotating part 220 drives the grid plate 210 to flip 180° to the reverse position, and the timing starts. The mouse grips the grid plate 210, and when the mouse hanging on the grid plate 210 releases the grid plate 210, the force moment array 410 is electrically connected to the processor and the timer, and the force moment array 410 senses that the grid plate 210 flips to the reverse position, and then the processor controls the timer to time. When the mouse falls from the grid plate 210, the pressure matrix is triggered, the timing is stopped, and the corresponding time length is recorded by the timer. When the rotating part 220 drives the grid plate 210 to flip 180° to the reverse position, the mouse hangs and grips the grid plate 210, and the pulling part 320 can be used to pull the mouse downward to monitor the muscle strength of the mouse with a force greater than the gravity of the mouse.

[0039] As another use mode, the grid plate 210 is in the forward position, the mouse wearing the mouse coat 310 is placed on the grid plate 210, the pulling part 320 pulls the mouse upward with different constant forces, and the timing starts when the constant force is applied. The mouse grips the grid plate 210, and when the mouse releases the grid plate 210, the pressure matrix is triggered, the timing is stopped, and the corresponding time length is recorded.

[0040] In some embodiments, referring to Figure 3 and Figure 4 , the grid plate 210 includes a frame 211 and a plate 212 arranged in the frame 211, and the plate 212 is detachably connected with the frame 211. In the specific implementation process, the plate 212 is connected with the frame 211 by buckling, bolts or glue. After repeated use of the grid plate 210, the experimenter can maintain the entire grid plate 210 by replacing the plate 212, which is simple to operate and the grid plate 210 can be reused.

[0041] A plurality of through holes are formed on the plate 212, and adjacent through holes form an intermediate strip 212b for the mouse to grip. The intermediate strip 212b is relatively curved, and the curved intermediate strip 212b is more suitable for the mouse to grip. Compared with the horizontal and vertical grid, it is more in line with the requirements of biomechanics, can fully exert the muscle strength of the mouse, and obtain more accurate experimental data.

[0042] As a further embodiment, the intermediate strip 212b is relatively smooth, eliminating the corresponding corners, which can avoid causing damage to the limbs and soles of the mouse. The cross section of the intermediate strip 212b is preferably circular, which is more convenient for the mouse to grip.

[0043] In some embodiments, referring to Figure 4The plate body 212 is provided with an attracting bin 212c away from one side of the mouse, and food for attracting the mouse is stored in the attracting bin 212c, so as to attract the mouse to continuously hold the grid plate 210, reduce the probability that the mouse subjectively releases the holding, and make the experimental data not distorted.

[0044] Please refer to Figure 5 The turning assembly 200 further comprises a driving member 230 fixedly connected with the box body 100, and an output shaft of the driving member 230 is connected with the rotating member 220 through a universal joint 240. The driving member 230 is specifically a servo motor, which can rotate 180° accurately and keep constant, thereby providing a basic support for the working of the testing device.

[0045] The universal joint 240 is arranged between the output shaft of the driving member 230 and the rotating member 220, and can be a shaft type, a ball cage type, a ball fork type, a bump type, a ball pin type, a ball hinge type, a ball hinge plunger type, a three-pin type, a three-pronged rod type, a three-ball pin type or a hinge rod type, etc. The universal joint 240 can transmit the torque from the output shaft to the rotating member 220. Moreover, the rotating member 220 is subjected to pressure on one side of the grid plate 210, and a bending moment is generated at the connection between the rotating member 220 and the box body 100. The universal joint 240 can offset the influence of the output shaft on the bending moment, thereby relieving the interference of the output shaft on the pressure matrix.

[0046] As a further embodiment, when the grid plate 210 is in the forward position or the reverse position, the shaft of the universal joint located on one side of the rotating member 220 is horizontally arranged, and the bending moment of the rotating member 220 can be offset after being appropriately rotated at the shaft.

[0047] It should be noted that the rotating member 220 is specifically a shaft, which is a rigid shaft and cannot be bent or deformed.

[0048] In some embodiments, please refer to Figure 2 The mouse coat 310 comprises a restraint part for binding the waist of the mouse, and the restraint part is connected with the pulling member 320. The restraint part only fixes the waist of the mouse, and the limbs of the mouse are not interfered by the restraint part and can freely move and hold the grid plate 210, so that the test results of the testing device are more real and accurate.

[0049] In some embodiments, please continue to refer to Figure 2 The pulling assembly 300 further comprises a pulling unit 330, which can provide a continuous upward pulling force to the pulling member 320, and the pulling force can be adjusted as needed, so as to test the muscle strength of the mouse with different pulling forces.

[0050] As one of the embodiments, the pulling unit 330 includes a guide wheel 331 and a weight 332, and the pulling member 320 is connected to the weight 332 through the guide wheel 331 at one end away from the mouse coat 310. In a specific implementation, a transmission bin is arranged at the upper part of the box body 100, two oppositely arranged guide wheels 331 are arranged in the transmission bin, the pulling member 320 is sleeved on the two guide wheels 331, the reversing of the pulling member 320 is realized, so that the pulling member 320 is arranged in a whole "door" shape, and the gravity of the weight 332 is applied to the mouse through the guidance of the pulling member 320, thereby generating a continuous pulling force on the mouse.

[0051] As one of the embodiments, the pulling unit 330 includes an elastic member, two ends of the elastic member are connected to the top of the box body 100 and the pulling member 320 respectively, and by adjusting the length of the pulling member 320, the pulling force on the mouse when gripping the mesh plate 212a can be controlled.

[0052] It should be noted that the pulling member 320 is specifically a traction rope, the traction rope is a non-stretchable rigid rope, which can be made of chemical fiber material or steel wire knitting, and the elastic member is specifically a spring, the pulling force of which remains constant when a certain stretching length is maintained.

[0053] At the same time, in order to prevent the pulling member 320 from driving the mouse to move upward and hit the top of the box body 100, the movable distance of the pulling member 320 is less than the distance between the mouse and the top of the box body 100, so as to avoid the collision between the mouse and the box body. A flexible layer can also be arranged on the top of the box body 100, which is specifically sponge or cotton cloth, etc., so that when the mouse accidentally hits the box body 100, the damage to the mouse can be reduced.

[0054] In some embodiments, referring to Figure 5 and Figure 6 , the force measuring assembly 400 further includes an outer ring 420 and an inner ring 430 arranged in a nested manner, the outer ring 420 is fixedly connected to the box body 100, the inner ring 430 is sleeved on the rotating member 220, a bearing is arranged between the rotating member 220 and the inner ring 430, the rotating member 220 can drive the inner ring 430 to move relative to the outer ring 420, thereby extruding the force measuring matrix 410 located between the inner and outer rings 420, the force measuring matrix 410 is arranged between the inner ring 430 and the outer ring 420, the force measuring matrix 410 can measure the force change of the inner ring 430 relative to the outer ring 420, thereby estimating the gravity change of the rotating member 220, and further judging the time when the mouse separates from the mesh plate 210. The inner ring 430, the outer ring 420 and the force measuring matrix 410 are combined into a whole, forming a kind of circumferential force measuring element, which can measure the force change of the rotating member 220.

[0055] Please refer to Figure 6, the force measuring matrix 410 comprises at least two pressure sensors 411, which are arranged around the central axis of the inner ring 430 and abut against the inner ring 430 and the outer ring 420 respectively. When the pressure sensors 411 are two, the two pressure sensors 411 are arranged vertically on both sides of the inner ring 430 opposite to the grid plate 210 in the forward position, and the pressure sensors 411 can measure the pressure change of the grid plate 210 in the upward forward position or the reverse position, obtain the force data of the rotating member 220 in the vertical direction, and thus accurately obtain the time when the mouse escapes from the grid plate 210. Other pressure sensors 411 can be arranged between the two pressure sensors 411, so as to more comprehensively record and analyze the force of the rotating member 220.

[0056] In some embodiments, referring to Figure 1 The lower part of the box 100 is provided with a plurality of pullable safety compartments 120, which are inserted into the test chambers 110, and the inside of the safety compartments 120 is paved with a flexible layer, which is sponge or foam, to protect the falling mice from being hurt.

[0057] Meanwhile, a plurality of openable doors are arranged on one side of the box 100, each of which is communicated with one test chamber 110, and the mice can be controlled through the doors.

[0058] It should be noted that the grid plate 210 and the safety compartment 120 are arranged separately, and the rotation of the grid plate 210 is independent of the safety compartment 120, and the grid plate 210 does not interfere with the safety compartment 120.

[0059] In some embodiments, the box 100 is made of transparent material, which is plastic or high-molecular resin, so that the experimenters can observe the real-time state of the mice through the box 100, and accidents can be avoided in the experiment.

[0060] The application provides a mouse muscle strength testing method, which is completed by using the mouse muscle strength testing device disclosed in the application. In some medical experiments, such as testing the influence of different doses of poison, muscle relaxant or anesthetic on muscle strength. After the mouse is injected with the corresponding drug, the mouse is too fast or too slow to get off the grid plate 210, which is not conducive to the comparative analysis of the experimental results. In the application, the pulling piece 320 of the mouse muscle strength testing device gives the mouse a constant force in the vertical direction away from the grid plate 210, changes the force of the mouse relative to the grid plate 210, and tests the time length of the mouse muscle strength with different forces. Therefore, the gripping time of the mouse without injecting drugs on the grid plate 210 can be adjusted as needed in the comparative experiment, so that the experimental data of other drugs can be changed gradually with the change of the experimental variables, and the test of different drugs is more true and accurate. With the increase of the dose of poison, muscle relaxant or anesthetic, the gripping time of the mouse on the grid plate 210 will gradually shorten, and then the influence of various drugs on the mouse muscle can be quantitatively explored.

[0061] Workflow: First, adjust the driving piece 230 to the grid plate 210 to be in the positive position, place the mouse wearing the mouse coat 310 on the grid plate 210, the mouse grips the middle strip 212b, releases the support of the pulling piece 320 away from the side of the mouse coat 310, the pulling piece 320 pulls the mouse away from the grid plate 210 with a constant force, and the gripping time of the mouse under different pulling forces is obtained by changing the pulling force of the pulling piece 320. Next, remove the mouse coat 310 of the mouse, place the mouse on the grid plate 210, rotate the driving piece 220 to drive the grid plate 210 to flip 180° to the reverse position, and start timing. The mouse grips the grid plate 210, and when the mouse hanging on the grid plate 210 releases the grid plate 210 and falls off the grid plate 210, the pressure matrix is triggered, the timing is stopped, and the corresponding time length is recorded.

[0062] The pulling assembly 300 is arranged in the test chamber 110 and relative to the grid plate 210. The pulling assembly 300 includes the mouse coat 310 and the pulling piece 320. The mouse coat 310 is used to bind the mouse, and the pulling piece 320 can adjust the pulling force. The pulling piece 320 is vertically arranged and fixedly connected with the mouse coat 310. When the mouse grips the middle strip 212b downward, the pulling piece 320 can vertically pull the mouse upward with a constant force, so as to test the muscle strength of the mouse with a force smaller than or greater than the weight of the mouse. Therefore, more abundant test data can be obtained, and the mouse muscle strength can be researched comprehensively.

[0063] The above is only the preferred specific embodiment of the application, but the protection scope of the application is not limited to this. Any changes or replacements within the technical range disclosed in the application can be easily thought by those skilled in the art, which should be covered in the application.

Claims

1. A mouse muscle strength testing device, characterized in that, include: The enclosure includes multiple test chambers spaced apart from each other; The flipping assembly includes a grid plate that can be flipped 180° and a rotating component. The grid plates are respectively disposed in the multiple test chambers, and each grid plate is rotatably connected to the box body through a rotating component. A lifting assembly is positioned relative to the mesh plate. The lifting assembly includes a mouse coat for restraining the mouse, an adjustable traction member, and a traction unit. The traction member is vertically positioned and fixedly connected to the mouse coat. The traction unit includes a guide wheel and a weight. The end of the traction member away from the mouse coat is connected to the weight via the guide wheel. The weight can provide a constant traction force to the traction member. A force measuring component, comprising a force measuring matrix disposed between the rotating component and the housing, the force measuring matrix being capable of measuring the force change of the rotating component, and the force measuring matrix being electrically connected to a processor and a timer.

2. The mouse muscle strength testing device according to claim 1, characterized in that, The grid plate includes a frame and a plate disposed in the frame. The plate has multiple through holes, and a middle strip is formed between adjacent through holes for mice to grasp. The middle strip is relatively curved.

3. The mouse muscle strength testing device according to claim 2, characterized in that, The plate has an enticement chamber for storing food on the side away from the mouse, and the enticement chamber is connected to the through hole.

4. The mouse muscle strength testing device according to claim 1, characterized in that, The flipping assembly also includes a driving component, which is fixedly connected to the housing, and the output shaft of the driving component is connected to the rotating component via a universal coupling.

5. The mouse muscle strength testing device according to claim 1, characterized in that, The mouse coat includes a restraint part for binding the mouse's waist, and the restraint part is connected to the traction member.

6. The mouse muscle strength testing device according to claim 1, characterized in that, The force measuring component also includes an outer ring and an inner ring nested together. The outer ring is fixedly connected to the housing, the inner ring is fitted onto the rotating component, and the force measuring matrix is ​​disposed between the inner ring and the outer ring.

7. The mouse muscle strength testing device according to claim 6, characterized in that, The force measurement matrix includes at least two pressure sensors, which are arranged around the central axis of the inner ring and respectively abut against the inner and outer rings. The pressure sensors are capable of measuring the force on the rotating component in the vertical direction.

8. The mouse muscle strength testing device according to claim 1, characterized in that, The lower part of the box is equipped with multiple pull-out safety compartments, which are inserted into the test chamber to catch the falling mice.

9. A method for testing muscle strength in mice, characterized in that, The mouse muscle strength is tested using a mouse muscle strength testing device as described in any one of claims 1-8. The traction member applies a constant force to the mouse in the vertical direction away from the grid plate to change the force exerted by the mouse relative to the grid plate, and the duration of the mouse's muscle grip is tested with different forces.

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