A biological sample cooling device and a multifunctional cooling system

Abstract

This invention discloses a biological sample cooling device and a multifunctional cooling system, including a cavity assembly, a cooling regulation assembly, a circulating cooling assembly, a biological plate rack and transport assembly, a lifting assembly, a support frame assembly, a lid opening assembly, a rotating liquid dispensing assembly, a plate rack gripping assembly, a pipette assembly, a sample storage box, a barcode scanner, and a transport container. The beneficial effects of this invention are that the cooling regulation assembly slowly cools the single-plate biological sample, the temperature of the liquid nitrogen in the circulating cooling assembly is detected, and when the temperature is too low, gas from the cavity assembly is drawn into the heating module for heating. The circulating cooling assembly can store multiple sets of biological samples. The lifting assembly raises the transport container to dock with the cavity assembly. The plate rack gripping assembly and the pipette assembly grip the biological plate rack or single-tube biological sample, thereby placing the biological plate rack or single-tube biological sample into the cooling regulation assembly or the circulating cooling assembly to achieve cooling of the biological sample.

Description

Technical Field

[0001] This invention relates to the field of biological sample storage technology, and in particular to a biological sample cooling device and a multifunctional cooling system. Background Technology

[0002] Currently, cryopreservation tubes and boxes for biological samples do not have automated cooling functions. Biological samples usually need to be preserved in ultra-low temperature environments to maintain their activity. Storage temperatures are generally -80℃, -140℃, -196℃, etc. The freezing speed of biological samples plays an important role in their activity. The conventional storage method is to directly place the cryopreservation box from the transfer box or transfer tank into the container, without implementing a certain gradient and slow cooling action, which can easily cause the biological sample to drop in temperature too quickly and cause damage.

[0003] Therefore, the inventors have developed a device for slowly cooling biological samples, and added the ability to heat the gas inside the chamber when the liquid nitrogen temperature is too low, so as to restore the temperature of the cooling environment, and to cool and preserve multiple biological sample racks. Summary of the Invention

[0004] The purpose of this section is to outline some aspects of embodiments of the present invention and to briefly describe some preferred embodiments. Simplifications or omissions may be made in this section, as well as in the abstract and title of this application, to avoid obscuring the purpose of these documents; however, such simplifications or omissions should not be construed as limiting the scope of the invention.

[0005] In view of the problems existing in the above or prior art, the present invention is proposed.

[0006] Therefore, the purpose of this invention is to provide a biological sample cooling device that can cool biological samples in a biological plate holder. The cooling adjustment component can slowly and gradually cool the biological samples. When the circulating cooling component detects that the liquid nitrogen temperature is too low, it can draw in gas, heat the gas, and send it into the circulation chamber. When used in conjunction with liquid nitrogen, the temperature of the liquid nitrogen can be increased, so that the biological samples can be slowly cooled. The circulation chamber can hold multiple sets of biological samples.

[0007] To solve the above-mentioned technical problems, the present invention provides the following technical solution: a biological sample cooling device, which includes a cavity assembly, a cooling regulation assembly, a circulating cooling assembly, and a biological plate rack;

[0008] The cavity assembly is equipped with a cooling regulation component and a circulating cooling component. The circulating cooling component is located to the side of the cooling regulation component and can independently perform gradient cooling on the bio-plate. The circulating cooling component can accommodate multiple sets of bio-plates and can adjust the temperature of the multiple sets of bio-plates inside. At least one cooling regulation component and / or circulating cooling component is provided.

[0009] As a preferred embodiment of the biological sample cooling device of the present invention, the cooling adjustment component includes a cooling cylinder and a lifting and retrieval component;

[0010] A lifting and retrieval device is installed above the cooling cylinder. The lifting and retrieval device can drive the biological board rack into the cooling cylinder. Liquid nitrogen is installed inside the cooling cylinder. The cooling cylinder can control the temperature of the liquid nitrogen. The lifting and retrieval device can detect the temperature of the biological board rack and the ambient temperature of the biological board rack.

[0011] As a preferred embodiment of the biological sample cooling device of the present invention, the cooling cylinder includes a cooling vacuum cylinder, a liquid nitrogen valve, and a liquid addition pipe;

[0012] The cooling vacuum cylinder is connected and fixed to the cavity assembly, and the liquid nitrogen valve can control the liquid addition pipeline to place liquid nitrogen inside the cooling vacuum cylinder.

[0013] As a preferred embodiment of the biological sample cooling device of the present invention, the lifting and retrieval component includes a support plate, a support slide plate, a guide rail support plate, a lead screw, a guide slider, a fixing block, a buffer spring, a temperature sensor, a sample temperature detection tube, a plate rack storage platform, a first motor, and a slider guide rail.

[0014] The support plate has a support slide plate on its side, and a guide rail support plate is connected to the side of the support slide plate. A first motor support platform is connected to the upper side of the guide rail support plate, and a first motor is mounted on the first motor support platform. The first motor is vertically connected to a lead screw via a drive shaft. The lead screw is connected to a fixed block and a guide slider. A slider guide rail is fixedly installed on the side of the guide rail support plate. The guide slider, the fixed block, and the slider guide rail are slidably connected. A buffer spring is connected to the lower end of the fixed block, and a temperature sensor is connected to the lower end of the buffer spring. A sample temperature detection tube is installed at the lower end of the temperature sensor. A plate rack storage platform is connected to the lower end of the guide rail support plate, which can hold biological plate racks. A chain is connected to the side of the support slide plate, and the support slide plate and the support plate are slidably connected up and down.

[0015] As a preferred embodiment of the biological sample cooling device of the present invention, the circulating cooling component includes a circulating cylinder, a suction component, and a heating component;

[0016] The circulating cylinder is connected and fixed to the cavity assembly. The lower end of the circulating cylinder is connected to the heating element through a pipe. The heating element is connected to the suction element, and the suction element is connected to the cavity assembly.

[0017] As a preferred embodiment of the biological sample cooling device of the present invention, the suction component includes a fan, a perforated plate, and a suction pipe;

[0018] A perforated plate is connected above the fan, and the fan is connected to the suction pipe.

[0019] As a preferred embodiment of the biological sample cooling device of the present invention, the heating element includes a heating module and an air inlet pipe;

[0020] The heating module is connected to the air intake pipe, and the heating module is also connected to the air inlet pipe.

[0021] As a preferred embodiment of the biological sample cooling device of the present invention, the circulation cylinder includes a docking chamber, a nitrogen spray pipe, a jet pipe, a cooling plate, and a circulation cylinder.

[0022] The air inlet pipe is connected to the docking chamber, which is located inside the circulation cylinder. The nitrogen injection pipe is located around the docking chamber and is connected to it. The air jet pipe is located above the nitrogen injection pipe and is connected to the docking chamber through a pipe. Multiple sets of air jet pipes and nitrogen injection pipes are arranged circumferentially. The air jet pipes have circular holes opening upwards. A cooling plate with mesh holes is located above the air jet pipes. A plate rack column is located above the cooling plate. The biological plate rack can be placed inside the circulation cylinder through the plate rack column. Multiple sets of biological plate racks can be placed inside the circulation cylinder.

[0023] In a preferred embodiment of the biological sample cooling device of the present invention, the nitrogen spraying pipe is connected to the liquid addition pipe.

[0024] The beneficial effects of the biological sample cooling device of the present invention are as follows: The present invention can slowly and gradually cool a single biological sample through a cooling adjustment component, and can detect the temperature of liquid nitrogen through a circulating cooling component. When the temperature is too low, the gas in the cavity component is drawn into the heating module for heating, so that the liquid nitrogen is warmed up, thus realizing intelligent temperature regulation. Furthermore, multiple sets of biological samples can be stored in the circulating cooling component for joint temperature regulation.

[0025] Given that the biological board rack often needs to be placed into the circulation cylinder during use, the transfer process adds a board rack gripping component; since it is inconvenient to place the external biological board rack into the operating chamber, a transfer tank and a chamber component are designed for docking. Therefore, the inventors designed a multi-functional cooling system.

[0026] To address the aforementioned technical problems, the present invention also provides the following technical solution: a biological sample cooling device, which further includes a transport component, a lifting component, a support frame component, a lid opening component, a rotary liquid dispensing component, a plate holder gripping component, a pipette component, a sample storage box, a barcode scanner, and a transfer container;

[0027] The support frame assembly supports the transport assembly, lifting assembly, and cavity assembly. The transport assembly transports the transfer container, the lifting assembly lifts the transfer container and docks it with the cavity assembly, the lid opening assembly opens the top lid of the transfer container, the rotary liquid addition assembly adds liquid to the transfer container, the pipette assembly removes excess nitrogen, the plate holder grasping assembly grasps the biological plate holder, the sample storage box holds the biological plate holder, and the barcode scanner scans the labels on the biological plate holder.

[0028] As a preferred embodiment of the multifunctional cooling system of the present invention, the cavity assembly includes an operation support plate and an operation cavity shell. The operation support plate is connected to the upper part of the operation cavity shell, and the operation support plate and the operation cavity shell form an operation cavity. The operation cavity is provided with a lid opening assembly, a rotating liquid adding assembly, a plate holder grasping assembly, a pipette assembly, a sample temporary storage box, and a barcode scanner.

[0029] As a preferred embodiment of the multifunctional cooling system of the present invention, the support frame assembly includes a support frame and a support platform; the upper end of the support frame is connected to the operating support plate, and the side end of the support frame is provided with a support platform.

[0030] As a preferred embodiment of the multifunctional cooling system of the present invention, the transport components include a transport vehicle and a transport rail;

[0031] The transport guide rail is set above the support platform, and the transport vehicle is slidably connected to the transport guide rail.

[0032] As a preferred embodiment of the multifunctional cooling system of the present invention, the lifting assembly includes a lifting guide rail, a lifting motor, a lifting screw, a lifting slider, a lifting U-shaped plate, and a lifting plate;

[0033] The lifting guide rail is vertically fixed to the support frame, the lifting slider is connected to the lifting screw, the upper and lower ends of the lifting guide rail are used to support the lifting screw, the lifting motor rotates the lifting screw through the pulley, the lifting slider is fixedly connected to the side of the lifting U-shaped plate, the lifting plate is set in the upper middle position of the transport vehicle, the transfer tank is set on the upper surface of the lifting plate, and the lifting U-shaped plate can raise and lower the lifting plate.

[0034] As a preferred embodiment of the multifunctional cooling system of the present invention, the opening assembly includes a door cover plate, a door cover motor, and a door cover shaft.

[0035] The door cover motor is connected to the door cover shaft, the door cover plate is connected to the door cover shaft, the door cover shaft is supported by the door cover support seat, and the door cover support seat is connected to the operating support plate.

[0036] As a preferred embodiment of the multifunctional cooling system of the present invention, the plate gripping assembly includes an X-axis slide rail, a Y-axis slide rail, a gripper motor, a gripper shaft, and a plate gripper.

[0037] The Y-axis slide rail is connected to the inner side of the operating cavity shell. The Y-axis slide rails are symmetrically arranged. The two symmetrical sets of Y-axis slide rails are connected by the X-axis slide rail. The X-axis slide rail and the Y-axis slide rail are slidably connected. A gripper motor is set on one side of the X-axis slide rail. The gripper motor and the gripper shaft are connected by a pulley. A plate gripper is connected below the gripper shaft.

[0038] As a preferred embodiment of the multifunctional cooling system of the present invention, the suction tube assembly includes an electric cylinder, a suction tube motor, a liquid nitrogen cup, a suction tube screw, a suction tube, and a suction head;

[0039] The electric cylinder is located on the side of the X-axis slide rail away from the gripper motor. A motor guide rail is provided on the side of the electric cylinder. A suction motor is slidably connected to the motor guide rail. A suction screw is connected to the suction motor. A suction tube is connected below the suction motor. A liquid nitrogen cup is provided on the outside of the suction tube. The lower end of the suction tube is connected to the suction head.

[0040] In a preferred embodiment of the multifunctional cooling system of the present invention, a sample storage box is mounted on an operating support plate, a biological plate rack can be stored inside the sample storage box, a second door cover is provided above the sample storage box, and a motor of the second door cover drives the second door cover to open or close the sample storage box.

[0041] As a preferred embodiment of the multifunctional cooling system of the present invention, the rotary liquid adding assembly includes a rotary liquid adding motor, a liquid adding cylinder, and a liquid replenishment pipe;

[0042] The rotary liquid dispensing motor is connected to the liquid dispensing cylinder via a pulley, and the liquid replenishment pipe is connected to the liquid dispensing cylinder. The liquid dispensing cylinder is supported by a support shaft, which is connected to the inner side of the operating chamber shell.

[0043] The beneficial effects of the multifunctional cooling system of the present invention are as follows: The present invention can move the transfer tank to the top of the lifting component through the transport component. The lifting component drives the transfer tank to rise and dock with the cavity component. After docking, the opening component can open the top cover of the transfer tank. The plate holder grasping component and the pipette component are used to grasp the biological plate holder or biological single tube sample, thereby placing the biological plate holder or biological single tube sample into the cooling regulation component or the circulating cooling component to achieve cooling of the biological sample. Attached Figure Description

[0044] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Wherein:

[0045] Figure 1 A schematic diagram of the overall device for cooling biological samples.

[0046] Figure 2 A schematic diagram of the hidden operating chamber shell of the device for cooling biological samples.

[0047] Figure 3 A three-dimensional schematic diagram of the cooling regulation component and the circulating cooling component of the biological sample cooling device.

[0048] Figure 4 This is an enlarged view of point F1 in the biological sample cooling device.

[0049] Figure 5 A schematic diagram showing the disassembly of the circulating cooling component of the biological sample cooling device.

[0050] Figure 6 A magnified view of point F2 in the biological sample cooling device.

[0051] Figure 7 This is a three-dimensional schematic diagram of a multi-functional cooling system.

[0052] Figure 8 This is a schematic diagram of a multi-functional cooling system from another perspective.

[0053] Figure 9 This is a schematic diagram of the rotating liquid dispensing assembly of a multifunctional cooling system.

[0054] Figure 10 This is a schematic diagram of the straw assembly of a multi-functional cooling system.

[0055] Figure 11 This is a schematic diagram of the plate gripping component for a multi-functional cooling system.

[0056] Figure 12 This is a schematic diagram of the lifting component of a multi-functional cooling system.

[0057] Reference numerals: 1. Cavity assembly; 2. Cooling regulation assembly; 3. Circulating cooling assembly; 15. Bioplate rack; 21. Cooling cylinder; 22. Lifting and retrieval assembly; 211. Cooling vacuum cylinder; 212. Liquid nitrogen valve; 213. Liquid filling pipe; 221. Support plate; 222. Support slide plate; 223. Guide rail support plate; 224. Lead screw; 225. Guide slider; 226. Fixing block; 227. Buffer spring; 228. Temperature sensor; 229. 8; Sample temperature detection tube, 229; Plate rack storage platform, 230; First motor, 231; Slider guide rail, 232; Circulation cylinder, 31; Suction unit, 33; Heating unit, 35; Fan, 331; Mesh plate, 332; Suction pipe, 333; Heating module, 351; Air inlet pipe, 352; Docking cavity, 311; Nitrogen spray pipe, 312; Air jet pipe, 313; Cooling tray, 314; Circulation cylinder, 315; Transport assembly, 4; 5. Lifting assembly; 6. Support frame assembly; 7. Opening assembly; 8. Rotary liquid dispensing assembly; 9. Plate holder gripping assembly; 10. Pipette assembly; 11. Sample storage box; 12. Barcode scanner; 13. Transfer container; 111. Operating support plate; 112. Operating chamber shell; 61. Support frame; 62. Support platform; 41. Transport vehicle; 42. Transport guide rail; 51. Lifting guide rail; 52. Lifting motor; 53. Lifting screw; 54. Lifting slider. 4; Lifting U-shaped plate, 55; Lifting plate, 56; Door cover plate, 71; Door cover motor, 72; Door cover pivot, 73; X-axis slide rail, 911; Y-axis slide rail, 912; Handle motor, 913; Handle pivot, 914; Plate frame handle, 915; Straw motor, 102; Liquid nitrogen cup, 104; Straw screw, 105; Straw, 106; Suction head, 107; Rotary liquid dispensing motor, 81; Liquid dispensing cylinder, 82; Replenishment pipe, 83; Detailed Implementation

[0058] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0059] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of the invention. Therefore, the invention is not limited to the specific embodiments disclosed below.

[0060] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that is mutually exclusive with other embodiments.

[0061] Example 1

[0062] Reference Figures 1-6 This is the first embodiment of the present invention, which provides a biological sample cooling device, including a cavity assembly 1, a cooling regulation assembly 2, a circulating cooling assembly 3, and a biological plate rack 15. By setting the cavity assembly 1, a sealed operating cavity can be formed inside. The circulating cooling assembly 3 can perform gradient cooling on individual biological plates rack 15. Multiple single-tube biological samples can be placed on the biological plate rack 15. The circulating cooling assembly 3 can detect the temperature of liquid nitrogen. If the temperature is too low, the gas in the cavity assembly 1 will be drawn into the heating module for heating and mixing with the liquid nitrogen, thereby increasing the temperature of the liquid nitrogen and allowing the biological samples to cool down slowly, thus achieving intelligent temperature regulation. Furthermore, the circulating cooling assembly 3 can store multiple sets of biological plates rack 15, greatly improving work efficiency.

[0063] Specifically, it includes cavity assembly 1, cooling regulation assembly 2, circulating cooling assembly 3, and biological plate rack 15;

[0064] The cavity assembly 1 is provided with a cooling adjustment assembly 2 and a circulating cooling assembly 3. The circulating cooling assembly 3 is located to the side of the cooling adjustment assembly 2. The cooling adjustment assembly 2 can independently perform gradient cooling on the biological plate rack 15. The circulating cooling assembly 3 can accommodate multiple sets of biological plate racks 15. The circulating cooling assembly 3 can adjust and control the temperature of the multiple sets of biological plate racks 15 inside it. At least one set of cooling adjustment assembly 2 and / or circulating cooling assembly 3 is provided.

[0065] Preferably, the circulating cooling component 3 can be set to multiple groups, so that more biological samples can be stored.

[0066] Furthermore, the cooling adjustment component 2 includes a cooling cylinder 21 and a lifting and retrieval component 22;

[0067] A lifting and retrieval component 22 is provided above the cooling cylinder 21. The lifting and retrieval component 22 can drive the biological plate frame 15 into the cooling cylinder 21. Liquid nitrogen is provided inside the cooling cylinder 21. The cooling cylinder 21 can control the temperature of the liquid nitrogen. The lifting and retrieval component 22 can detect the temperature of the biological plate frame 15 and the ambient temperature of the biological plate frame 15.

[0068] Preferably, the operating support plate 111 has a slot, the cooling cylinder 21 is placed in the slot, and the lifting and retrieval component 22 can drive the biological plate frame 15 to move up and down.

[0069] Furthermore, the cooling cylinder 21 includes a cooling vacuum cylinder 211, a liquid nitrogen valve 212, and a liquid addition pipe 213;

[0070] The cooling vacuum cylinder 211 is connected and fixed to the cavity assembly 1, and the liquid nitrogen valve 212 can control the liquid addition pipe 213 to place liquid nitrogen in the cooling vacuum cylinder 211.

[0071] Preferably, the cooling vacuum cylinder 211 is fixed to the operating support plate 111, and liquid nitrogen can be flowed into the cooling vacuum cylinder 211 through the liquid addition pipe 213.

[0072] Furthermore, the lifting and retrieval component 22 includes a support plate 221, a support slide plate 222, a guide rail support plate 223, a lead screw 224, a guide slider 225, a fixing block 226, a buffer spring 227, a temperature sensor 228, a sample temperature detection tube 229, a plate rack storage platform 230, a first motor 231, and a slider guide rail 232.

[0073] A support plate 222 is provided on the side of the support plate 221. A guide rail support plate 223 is connected to the side of the support plate 222. A first motor support platform is fixedly connected to the upper side of the guide rail support plate 223. A first motor 231 is mounted on the first motor support platform. The first motor 231 is vertically connected to a lead screw 224 via a transmission shaft. The lead screw 224 is connected to the guided slider 225. A fixing block 226 is fixedly connected to the guided slider 225. A slider guide rail 232 is fixedly provided on the side of the guide rail support plate 223. The guided slider 225... The fixed block 226 is slidably connected to the slider guide rail 232. The lower end of the fixed block 226 is connected to the buffer spring 227. The lower end of the buffer spring 227 is connected to the temperature sensor 228. The lower end of the temperature sensor 228 is provided with a sample temperature detection tube 229. The lower end of the guide rail support plate 223 is connected to the plate rack storage platform 230, which can hold the biological plate rack 15. The side of the support slide plate 222 is connected to a chain, which can drive the support slide plate 222 to move up and down. The support slide plate 222 and the support plate 221 are slidably connected up and down.

[0074] Preferably, the support plate 221 is connected and fixed to the inner side of the operating cavity housing 112, and the support slide plate 222 slides up and down along the track on the side of the support plate 221.

[0075] The movement process of the lifting and retrieval component 22: The motor drives the chain to move the support slide plate 222 up and down along the track on the side of the support plate 221, which in turn drives the first motor 231 to move. The plate storage platform 230, which is fixed to the support slide plate 222, also moves at the same time. The biological plate shelf 15 on the plate storage platform 230 also moves. When it moves downward, it drives the biological plate shelf 15 into the cooling vacuum cylinder 211. The first motor 231 drives the lead screw 224 to rotate. The lead screw 224 drives the fixing block 226 to move up and down. The fixing block 226 drives the temperature sensor 228 and the sample temperature detection tube 229 to move. The cooling vacuum cylinder controls the temperature drop of liquid nitrogen. At the same time, the sample temperature detection tube 229 detects the temperature of the biological tube in the biological plate shelf 15, and the temperature sensor 228 detects the temperature of the liquid nitrogen.

[0076] It should be noted that when the biological sample in the biological plate holder 15 is placed into the cooling vacuum cylinder 211, the cooling vacuum cylinder 211 lowers the temperature of the biological sample by adjusting the temperature of the liquid nitrogen environment. First, the temperature of the biological sample is lowered from the ambient temperature of 20°C to 4°C; then, the sample temperature is lowered to -4°C at a rate of 1°C / minute; then, the ambient temperature is lowered to -40°C at a rate of 20°C / minute; then, the ambient temperature is lowered to -20°C at a rate of 15°C / minute; then, the ambient temperature is lowered to -40°C at a rate of 1°C / minute; finally, the ambient temperature is lowered to -90°C at a rate of 15°C / minute, at which point the cooling is completed. Through gradual step-cooling, the activity of the biological sample is ensured.

[0077] Furthermore, the circulating cooling component 3 includes a circulating cylinder 31, a suction component 33, and a heating component 35;

[0078] The circulation cylinder 31 is connected and fixed to the cavity assembly 1. The lower end of the circulation cylinder 31 is connected to the heating element 35 through a pipe. The heating element 35 is connected to the suction element 33. The suction element 33 is connected to the cavity assembly 1.

[0079] Preferably, the gas inside the cavity assembly 1 is drawn in by the suction component 33, heated by the heating component 35, and then the heated gas and liquid nitrogen are combined in the circulation cylinder 31 to raise the temperature of the liquid nitrogen and avoid rapid cooling.

[0080] Furthermore, the suction component 33 includes a fan 331, a perforated plate 332, and a suction pipe 333;

[0081] A perforated plate 332 is connected above the fan 331, and the fan 331 is connected to the suction pipe 333.

[0082] Preferably, the operating support plate 111 has holes for accommodating the perforated plate 332, which can filter out larger debris.

[0083] It should be noted that the circulating cooling component 3 can be set to multiple groups, which allows for the storage of more biological samples and the slow, intelligent cooling of the biological samples.

[0084] Furthermore, the heating element 35 includes a heating module 351 and an air inlet pipe 352;

[0085] The heating module 351 is connected to the suction pipe 333 and the air inlet pipe 352.

[0086] Preferably, the gas drawn in by the suction pipe 333 is heated by the heating module 351 and then sent into the air inlet pipe 352.

[0087] Furthermore, the circulation cylinder 31 includes a docking cavity 311, a nitrogen injection pipe 312, a jet pipe 313, a cooling plate 314, and a circulation cylinder 315;

[0088] The air inlet pipe 352 is connected to the docking cavity 311, which is located inside the circulation cylinder 315. The nitrogen spray pipe 312 is located around the docking cavity 311 and is connected to it. The jet pipe 313 is located above the nitrogen spray pipe 312 and is connected to the docking cavity 311 through a pipe. Multiple sets of jet pipes 313 and nitrogen spray pipes 312 are arranged circumferentially. The jet pipe 313 has a circular hole opening upwards. A cooling plate 314 is arranged above the jet pipe 313. The cooling plate 314 has a mesh hole opening. A plate rack column is arranged above the cooling plate 314. The biological plate rack 15 can be placed inside the circulation cylinder 315 through the plate rack column. Multiple sets of biological plate racks 15 can be arranged inside the circulation cylinder 315.

[0089] Preferably, the nitrogen injection pipe 312 and the jet pipe 313 can be configured as multi-resistance pipes. The docking cavity 311 can be fixedly connected to the air inlet pipe 352, or the docking cavity 311 can rotate around the air inlet pipe 352. This allows the nitrogen injection pipe 312 to rotate and the jet pipe 313 to rotate. The nitrogen injection pipe 312 and the jet pipe 313 are provided with round holes to facilitate the more uniform upward spraying of nitrogen and heating gas.

[0090] Furthermore, the nitrogen spray pipe 312 is connected to the liquid addition pipe 213.

[0091] During use, the cooling process of the cooling regulating component 2 is as follows: the motor drives the chain to move the support slide plate 222 up and down along the track on the side of the support plate 221, which in turn drives the first motor 231 to move. The plate storage platform 230, which is fixed to the support slide plate 222, also moves at the same time. The biological plate rack 15 on the plate storage platform 230 also moves. When it moves downward, it drives the biological plate rack 15 into the cooling vacuum cylinder 211. The first motor 231 drives the lead screw 224 to rotate. The lead screw 224 drives the fixing block 226 to move up and down. The fixing block 226 drives the temperature sensor 228 and the sample temperature detection tube 229 to move. The cooling vacuum cylinder controls the temperature drop of the liquid nitrogen. At the same time, the sample temperature detection tube 229 detects the temperature of the biological tube in the biological plate rack 15, and the temperature sensor 228 detects the temperature of the liquid nitrogen.

[0092] Cooling motion of the circulating cooling component 3: When the liquid nitrogen temperature is detected to be too low, the fan 331 draws the gas inside the cavity component 1 and enters the heating module 351 through the suction pipe 333. The heated gas continues to enter the circulation cylinder 315 through the air inlet pipe 352 and the docking cavity 311. The heated gas is sprayed out through the jet pipe 313 and mixes with the liquid nitrogen sprayed out by the nitrogen spray pipe 312. The jet pipe 313 also heats the cooling plate 314 above. Multiple sets of biological plate racks 15 are stored above the cooling plate 314, thereby heating the liquid nitrogen environment, realizing intelligent and adjustable cooling, and ensuring that the biological samples are cooled slowly.

[0093] In summary, this invention enables slow, gradient cooling of single-plate biological samples via the cooling adjustment component 2, and can detect both the temperature of liquid nitrogen and the temperature of the biological samples, preventing the liquid nitrogen from cooling the biological samples too quickly and causing them to lose their activity. The circulating cooling component 3 can detect the temperature of the liquid nitrogen, and when the temperature is too low, it draws gas from the cavity component 1 into the heating module for heating, thus warming the liquid nitrogen and achieving intelligent temperature regulation. Furthermore, the circulating cooling component 3 can store multiple sets of biological samples for joint temperature regulation.

[0094] Example 2

[0095] Reference Figures 7-12This is the second embodiment of the present invention, which, based on embodiment 1, further includes a multifunctional cooling system. The multifunctional cooling system includes a transport component 4, a lifting component 5, a support frame component 6, a lid opening component 7, a rotary liquid dispensing component 8, a plate holder gripping component 9, a pipette assembly 10, a sample storage box 11, a barcode scanner 12, and a transfer container 13. The transfer container 13 can be transported by the system; the lifting component 5 can lift the transfer container 13 and connect it to the cavity component 1; the lid opening component 7 can open the lid of the transfer container 13; and the rotary liquid dispensing component... Component 8 can add liquid to the transport container 13 and the sample storage box 11. By setting up a barcode scanner 12, it can scan and register single tube biological samples or whole plate biological samples. By setting up a plate holder grasping component 9 and a pipette component 10, it can grasp single tube biological samples or whole plate biological samples. The plate holder grasping component 9 and the pipette component 10 can grasp single tube samples or whole plate biological samples in the transport container 13 and temporarily put them into the sample storage box 11. The plate holder grasping component 9 can place the biological plate holder 15 on the plate holder storage platform 230 or into the circulation cylinder 315.

[0096] Specifically, it includes transport component 4, lifting component 5, support frame component 6, opening component 7, rotating liquid dispensing component 8, plate and frame gripping component 9, pipette component 10, sample storage box 11, barcode scanner 12, and transfer tank 13;

[0097] The support frame assembly 6 supports the transport assembly 4, the lifting assembly 5, and the cavity assembly 1. The transport assembly 4 can transport the transfer tank 13. The lifting assembly 5 can lift the transfer tank 13 and dock it with the cavity assembly 1. The lid opening assembly 7 can open the top cover of the transfer tank 13. The rotating liquid adding assembly 8 can add liquid to the transfer tank 13. The pipette assembly 10 can remove excess nitrogen gas. The plate holder grasping assembly 9 is used to grasp the biological plate holder 15. The sample temporary storage box 11 can place the biological plate holder 15. The barcode scanner 12 can scan the label of the biological plate holder 15.

[0098] Furthermore, the cavity assembly 1 includes an operation support plate 111 and an operation cavity shell 112. The operation support plate 111 is connected to the upper part of the operation cavity shell 112. The operation support plate 111 and the operation cavity shell 112 form a sealed operation cavity. The operation cavity is equipped with a lid opening assembly 7, a rotary liquid dispensing assembly 8, a plate holder gripping assembly 9, a pipette assembly 10, a sample storage box 11, and a barcode scanner 12.

[0099] Preferably, the outer shell 112 of the operating cavity is provided with an observation window, through which the internal condition can be observed.

[0100] Furthermore, the support frame assembly 6 includes a support frame 61 and a support platform 62; the upper end of the support frame 61 is fixedly connected to the operating support plate 111, and the support platform 62 is provided on the side end of the support frame 61. The support platform 62 is fixedly connected to the support frame 61.

[0101] Furthermore, the transport component 4 includes a transport vehicle 41 and a transport rail 42;

[0102] The transport guide rail 42 is located above the support platform 62, and the transport vehicle 41 is slidably connected to the transport guide rail 42.

[0103] Preferably, the transport guide rail 42 is fixedly connected to the support platform 62.

[0104] Furthermore, the lifting assembly 5 includes a lifting guide rail 51, a lifting motor 52, a lifting lead screw 53, a lifting slider 54, a lifting U-shaped plate 55, and a lifting plate 56;

[0105] The lifting guide rail 51 is vertically fixedly connected to the support frame 61. The lifting slider 54 is connected to the lifting screw 53. The upper and lower ends of the lifting guide rail 51 have protrusions to support the lifting screw 53. The lifting motor 52 drives the lifting screw 53 to rotate through the pulley. The lifting slider 54 is fixedly connected to the side of the lifting U-shaped plate 55. The lifting plate 56 is set in the upper middle position of the transport vehicle 41. The transfer tank 13 is set on the upper surface of the lifting plate 56. The lifting U-shaped plate 55 can lift the lifting plate 56.

[0106] Preferably, the upper part of the lifting U-shaped plate 55 has a top grab, and the lifting plate 56 is provided with a buckle, and the top grab and the buckle can cooperate.

[0107] Preferably, the lifting motor 52 drives the lifting screw 53 to rotate via a pulley. The rotation of the lifting screw 53 will drive the lifting slider 54 to move vertically along the lifting guide rail 51. When the lifting slider 54 rises, it will drive the top grab on the lifting U-shaped plate 55 to rise. When the top grab engages with the buckle on the lifting plate 56, it will lift the lifting plate 56, thereby driving the transfer tank 13 on the lifting plate 56 to rise, so that the transfer tank 13 engages with the operating support plate 111.

[0108] Furthermore, the cover opening assembly 7 includes a cover plate 71, a cover motor 72, and a cover pivot 73;

[0109] The door cover motor 72 is connected to the door cover shaft 73, the door cover plate 71 is connected to the door cover shaft 73, the door cover shaft 73 is supported by the door cover support seat, and the door cover support seat is connected to the operating support plate 111.

[0110] Preferably, the top cover of the transfer tank 13 can be made magnetic, and the door cover 71 can also be made magnetic, so that the top cover of the transfer tank 13 can be opened. Alternatively, the top cover of the transfer tank 13 can be opened by other means.

[0111] Preferably, the door cover motor 72 drives the door cover shaft 73 to open the top cover of the transfer tank 13 using the door cover plate 71. The door cover plate 71 can also close the slot on the operating support plate 111 that accommodates the transfer tank 13 when the transfer tank 13 is not in use, thus keeping the cavity sealed.

[0112] Furthermore, the plate gripping assembly 9 includes an X-axis slide rail 911, a Y-axis slide rail 912, a gripper motor 913, a gripper shaft 914, and a plate gripper 915;

[0113] The Y-axis slide rail 912 is connected to the inner side of the operating cavity housing 112. The Y-axis slide rails 912 are symmetrically arranged. The two symmetrical sets of Y-axis slide rails 912 are connected by the X-axis slide rail 911. The X-axis slide rail 911 is slidably connected to the Y-axis slide rail 912. A gripper motor 913 is provided on one side of the X-axis slide rail 911. The gripper motor 913 is connected to the gripper shaft 914 through a pulley. A plate gripper 915 is connected below the gripper shaft 914.

[0114] Preferably, the plate holder gripper 915 can move on the X-axis slide rail 911, and the X-axis slide rail 911 can slide along the Y-axis slide rail 912. The plate holder gripper 915 can grasp the biological plate holder 15.

[0115] Preferably, the plate holder gripper 915 can move up and down along the Z-axis. It can move up and down by driving the rotating shaft bracket and the motor bracket through the chain. The motor bracket can slide up and down with the X-axis slide rail, thereby enabling the plate holder gripper 915 to lift and lower. Alternatively, other existing technologies can be used, which only need to achieve the purpose of lifting and lowering the plate holder gripper 915 along the Z-axis.

[0116] Preferably, the plate holder gripper 915 can move in the XYZ axis directions. The plate holder gripper 915 can grasp the biological plate holder 15.

[0117] Furthermore, the straw assembly 10 includes an electric cylinder, a straw motor 102, a liquid nitrogen cup 104, a straw screw 105, a straw 106, and a straw head 107.

[0118] The electric cylinder is located on the side of the X-axis slide rail 911 away from the gripper motor 913. A motor guide rail is provided on the side of the electric cylinder. A suction motor 102 is slidably connected to the motor guide rail. A suction screw 105 is connected to the suction motor 102. A suction tube 106 is connected below the suction motor 102. A liquid nitrogen cup 104 is provided on the outside of the suction tube 106. The lower end of the suction tube 106 is connected to the suction head 107.

[0119] Preferably, the pipette 106 and the pipette tip 107 are connected by a pipette motor 102 driving the pipette screw 105 to rotate, and the pipette motor 102 will move up and down along the motor guide rail. The liquid nitrogen cup 104 can cool the pipette 106, and the pipette tip 107 can draw up a single sample. Alternatively, an electric cylinder can be used to drive the pipette motor 102 and the pipette 106 to move up and down. Alternatively, other existing technologies can be used to enable the pipette 106 to move up and down.

[0120] Furthermore, the sample storage box 11 is mounted on the operating support plate 111. The biological plate rack 15 can be stored inside the sample storage box 11. A second door cover is provided above the sample storage box 11. The motor of the second door cover opens or closes the sample storage box 11 by driving the second door cover.

[0121] Preferably, the bottom of the sample storage box 11 is connected to the liquid nitrogen valve 212 via a pipe, allowing liquid to be added to the sample storage box 11. A biological plate rack 15 can be temporarily placed inside the sample storage box 11, and the second door cover can be opened and closed.

[0122] Furthermore, the rotary dispensing assembly 8 includes a rotary dispensing motor 81, a dispensing cylinder 82, and a replenishment pipe 83;

[0123] The rotary liquid adding motor 81 is connected to the liquid adding cylinder 82 via a pulley, and the liquid replenishment pipe 83 is connected to the liquid adding cylinder 82. The liquid adding cylinder 82 is supported by a support shaft, which is connected to the inner side of the operating chamber shell 112.

[0124] Preferably, the rotary liquid adding motor 81 drives the liquid adding cylinder 82 to rotate via a pulley, and the liquid adding cylinder 82 drives the replenishment pipe 83 to rotate. By rotating, the replenishment pipe 83 can add or replenish liquid to the transfer tank 13 and the sample storage box 11 respectively.

[0125] In use, the transfer tank 13 is placed on the transport vehicle 41, which then moves along the transport guide rail 42 to above the lifting U-shaped plate 55. Next, the lifting motor 52 drives the lifting screw 53 to rotate via a pulley. The rotation of the lifting screw 53 causes the lifting slider 54 to move vertically along the lifting guide rail 51. As the lifting slider 54 rises, it causes the grabber on the lifting U-shaped plate 55 to rise as well. When the grabber engages with the latch on the lifting plate 56, the lifting plate 56 rises, thereby raising the transfer tank 13 on the lifting plate 56. This allows the transfer tank 13 to engage with the operating support plate 111. Then, the door cover motor 72 drives the door cover shaft 73 to open the door cover 71. The top cover of the transport tank 13 is rotated by a liquid-adding motor 81, which drives the liquid-adding cylinder 82 to rotate via a pulley. The liquid-adding cylinder 82 drives the replenishment tube 83. By rotating, the replenishment tube 83 can add or replenish liquid to the transport tank 13 and the sample storage box 11 respectively. Afterwards, under the system's command, the plate holder 915 will move along the XYZ axis to place the biological plate holder 15 in the transport tank 13 into the sample storage box 11 for later use. Alternatively, the pipette tip 107 can be used to grab a single tube and place it into the biological plate holder 15. Or, the plate holder 915 can grab the biological plate holder 15, scan it, and then place the biological plate holder 15 into the circulation cylinder 315 or the plate holder storage platform 230 for storage and cooling.

[0126] In summary, the present invention can move the transfer container 13 above the lifting component 5 through the transport component 4. The lifting component 5 drives the transfer container 13 to rise and dock with the cavity component 1. After docking, the opening component 7 can open the top cover of the transfer container 13. The plate holder grasping component 9 and the pipette component 10 are used to grasp the biological plate holder or biological single tube sample, thereby placing the biological plate holder or biological single tube sample into the cooling regulating component 2 or the circulating cooling component 3 to achieve cooling of the biological sample.

[0127] It is important to note that the constructions and arrangements of this application shown in several different exemplary embodiments are merely illustrative. Although only a few embodiments are described in detail in this disclosure, those who consult this disclosure will readily understand that many modifications are possible (e.g., changes in the size, dimensions, structure, shape, and proportions of various elements, as well as parameter values ​​(e.g., temperature, pressure, etc.), mounting arrangements, use of materials, color, orientation, etc.) without substantially departing from the novel teachings and advantages of the subject matter described in this application). For example, an element shown as integrally formed may be composed of multiple parts or elements, the position of elements may be inverted or otherwise altered, and the nature or number or position of discrete elements may be changed or altered. Therefore, all such modifications are intended to be included within the scope of the invention. The order or sequence of any process or method steps may be changed or rearranged according to alternative embodiments. In the claims, any "device plus function" clause is intended to cover the structure described herein that performs the function, and not only structurally equivalent but also equivalent in structure. Other substitutions, modifications, alterations, and omissions may be made in the design, operation, and arrangement of the exemplary embodiments without departing from the scope of the invention. Therefore, the present invention is not limited to the specific embodiments, but extends to various modifications that still fall within the scope of the appended claims.

[0128] Furthermore, in order to provide a concise description of exemplary embodiments, not all features of actual embodiments (i.e., those features that are not relevant to the best mode of carrying out the invention as currently considered, or those features that are not relevant to implementing the invention) may be omitted.

[0129] It should be understood that numerous specific implementation decisions can be made during the development of any practical implementation, such as in any engineering or design project. Such development efforts may be complex and time-consuming, but for those skilled in the art who benefit from this disclosure, the development effort will be a routine work of design, manufacturing, and production without requiring much experimentation.

[0130] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A biological sample cooling device, characterized in that: Includes cavity components, cooling and regulating components, circulating cooling components, and biological plate racks; The cavity assembly is equipped with a cooling regulation component and a circulating cooling component. The circulating cooling component is located to the side of the cooling regulation component and can independently perform gradient cooling on the bio-plates. The circulating cooling component can accommodate multiple sets of bio-plates and can adjust the temperature of the multiple sets of bio-plates inside. At least one set of the cooling regulation component and / or the circulating cooling component is provided. The circulating cooling component includes a circulating cylinder, a suction component, and a heating component; The circulating cylinder is connected and fixed to the cavity assembly. The lower end of the circulating cylinder is connected to the heating element through a pipe. The heating element is connected to the suction element. The suction element is connected to the cavity assembly. The suction component includes a fan, a perforated plate, and a suction pipe; A perforated plate is connected above the fan, and the fan is connected to the suction pipe; The cooling adjustment component includes a cooling cylinder and a lifting and retrieval component; A lifting and retrieval device is provided above the cooling cylinder, which can drive the bio-plate rack into the cooling cylinder. Liquid nitrogen is provided inside the cooling cylinder, and the temperature of the liquid nitrogen can be controlled. The lifting and retrieval device can detect the temperature of the bio-plate rack and the ambient temperature of the bio-plate rack. The cooling cylinder includes a cooling vacuum cylinder, a liquid nitrogen valve, and a liquid filling pipe; The cooling vacuum cylinder is connected and fixed to the cavity assembly, and the liquid nitrogen valve can control the liquid nitrogen supply pipe to place liquid nitrogen inside the cooling vacuum cylinder; The gas inside the cavity assembly is drawn in by the suction component, heated by the heating component, and then mixed with liquid nitrogen in the circulation cylinder to raise the temperature of the liquid nitrogen and prevent rapid cooling. The air inlet pipe is connected to the docking chamber, which is located inside the circulation cylinder. The nitrogen injection pipe is located around the docking chamber and is connected to it. The air jet pipe is located above the nitrogen injection pipe and is connected to the docking chamber through a pipe. Multiple sets of air jet pipes and nitrogen injection pipes are arranged circumferentially. The air jet pipe has a circular hole opening upwards. A cooling plate is located above the air jet pipe. The cooling plate has a mesh opening. A plate rack column is located above the cooling plate. The biological plate rack can be placed inside the circulation cylinder through the plate rack column. Multiple sets of biological plate racks can be placed inside the circulation cylinder.

2. The biological sample cooling device as described in claim 1, characterized in that: The lifting and retrieval component includes a support plate, a support slide plate, a guide rail support plate, a lead screw, a guide slider, a fixing block, a buffer spring, a temperature sensor, a sample temperature detection tube, a plate rack storage platform, a first motor, and a slider guide rail. The support plate has a support slide plate on its side, and a guide rail support plate is connected to the side of the support slide plate. A first motor support platform is connected to the upper side of the guide rail support plate, and a first motor is mounted on the first motor support platform. The first motor is vertically connected to the lead screw via a transmission shaft. The lead screw is connected to the fixed block and the guide slider. A slider guide rail is fixedly provided on the side of the guide rail support plate. The guide slider, the fixed block, and the slider guide rail are slidably connected. A buffer spring is connected to the lower end of the fixed block, and a temperature sensor is connected to the lower end of the buffer spring. A sample temperature detection tube is provided at the lower end of the temperature sensor. A plate rack storage platform is connected to the lower end of the guide rail support plate, and the plate rack storage platform can hold biological plate racks. A chain is connected to the side of the support slide plate, and the support slide plate is slidably connected to the support plate.

3. The biological sample cooling device as described in claim 1, characterized in that: The heating element includes a heating module and an air inlet pipe; The heating module is connected to the air intake pipe, and the heating module is connected to the air inlet pipe.

4. The biological sample cooling device as described in claim 3, characterized in that: The circulating cylinder includes a docking chamber, a nitrogen injection pipe, a jet pipe, a cooling plate, and a circulating cylinder; The air inlet pipe is connected to the docking cavity, which is located inside the circulation cylinder. The nitrogen injection pipe is located around the docking cavity and is connected to it. The air jet pipe is located above the nitrogen injection pipe and is connected to the docking cavity through a pipe. Multiple sets of air jet pipes and nitrogen injection pipes are arranged circumferentially. The air jet pipe has a circular hole opening upwards. A cooling plate is located above the air jet pipe, and a mesh hole is opened on the cooling plate. A plate rack column is located above the cooling plate, and the biological plate rack can be placed inside the circulation cylinder through the plate rack column. Multiple sets of biological plate racks can be arranged inside the circulation cylinder.

5. The biological sample cooling device as described in claim 4, characterized in that: The nitrogen spray pipe is connected to the liquid addition pipe.

6. A multifunctional cooling system, characterized in that: The biological sample cooling device according to any one of claims 1 to 5 includes a transport component, a lifting component, a support frame component, a lid opening component, a rotating liquid dispensing component, a plate and rack gripping component, a pipette component, a sample storage box, a barcode scanner, and a transfer container. The support frame assembly supports the transport assembly, the lifting assembly, and the cavity assembly. The transport assembly transports the transfer container, the lifting assembly lifts the transfer container and docks it with the cavity assembly, the lid opening assembly opens the top lid of the transfer container, the rotating liquid adding assembly adds liquid to the transfer container, the pipette assembly removes excess nitrogen, the plate holder grasping assembly grasps the biological plate holder, the sample storage box holds the biological plate holder, and the barcode scanner scans the label on the biological plate holder.

7. The multifunctional cooling system as described in claim 6, characterized in that: The cavity assembly includes an operating support plate and an operating cavity shell. The operating support plate is connected to the upper part of the operating cavity shell, and the operating support plate and the operating cavity shell form an operating cavity. The operating cavity is equipped with an opening assembly, a rotating liquid dispensing assembly, a plate holder gripping assembly, a pipette assembly, a sample storage box, and a barcode scanner.

8. The multifunctional cooling system as described in claim 7, characterized in that: The support frame assembly includes a support frame and a support platform; the upper end of the support frame is connected to the operating support plate, and the side end of the support frame is provided with a support platform.

9. The multifunctional cooling system as described in claim 8, characterized in that: The transport components include a transport vehicle and transport rails; The transport guide rail is disposed above the support platform, and the transport vehicle is slidably connected to the transport guide rail.

10. The multifunctional cooling system as described in claim 9, characterized in that: The lifting assembly includes a lifting guide rail, a lifting motor, a lifting lead screw, a lifting slider, a lifting U-shaped plate, and a lifting plate; The lifting guide rail is vertically fixedly connected to the support frame. The lifting slider is connected to the lifting screw. The upper and lower ends of the lifting guide rail have protrusions for supporting the lifting screw. The lifting motor drives the lifting screw to rotate through a pulley. The lifting slider is fixedly connected to the side of the lifting U-shaped plate. The lifting plate is located at the upper middle position of the transport vehicle. The transfer tank is located on the upper surface of the lifting plate. The lifting U-shaped plate can raise and lower the lifting plate.

11. The multifunctional cooling system as described in claim 10, characterized in that: The opening assembly includes a door cover plate, a door cover motor, and a door cover pivot. The door cover motor is connected to the door cover rotating shaft, the door cover plate is connected to the door cover rotating shaft, the door cover rotating shaft is supported by the door cover support seat, and the door cover support seat is connected to the operating support plate.

12. The multifunctional cooling system as described in claim 11, characterized in that: The plate gripping assembly includes an X-axis slide rail, a Y-axis slide rail, a gripper motor, a gripper shaft, and a plate gripper; The Y-axis slide rail is connected to the inner side of the operating cavity shell. The Y-axis slide rails are symmetrically arranged. The two symmetrical sets of Y-axis slide rails are connected by the X-axis slide rail. The X-axis slide rail is slidably connected to the Y-axis slide rail. A gripper motor is provided on one side of the X-axis slide rail. The gripper motor is connected to the gripper shaft through a pulley. A plate gripper is connected below the gripper shaft.

13. The multifunctional cooling system as described in claim 12, characterized in that: The straw assembly includes an electric cylinder, a straw motor, a liquid nitrogen cup, a straw screw, a straw, and a straw tip; The electric cylinder is located on the side of the X-axis slide rail away from the gripper motor. A motor guide rail is provided on the side of the electric cylinder. A suction motor is slidably connected to the motor guide rail. A suction screw is connected to the suction motor. A suction tube is connected below the suction motor. A liquid nitrogen cup is provided on the outside of the suction tube. The lower end of the suction tube is connected to the suction head.

14. The multifunctional cooling system as described in claim 13, characterized in that: The sample storage box is mounted on the operating support plate. The sample storage box can hold a biological plate rack. A second door cover is provided above the sample storage box. The motor of the second door cover drives the second door cover to open or close the sample storage box.

15. The multifunctional cooling system as described in claim 14, characterized in that: The rotary liquid dispensing assembly includes a rotary liquid dispensing motor, a liquid dispensing cylinder, and a liquid replenishment pipe; The rotary liquid dispensing motor is connected to the liquid dispensing cylinder via a pulley, the liquid replenishment pipe is connected to the liquid dispensing cylinder, the liquid dispensing cylinder is supported by a support shaft, and the support shaft is connected to the inner side of the operating chamber shell.

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