A haemostatic liquid dressing and its preparation and use

By optimizing the ratio of ingredients such as phosphatidylcholine and Soluplus, a rapid hemostatic dressing was formed, which solved the shortcomings of existing hemostatic materials and achieved a rapid and firm hemostatic effect, suitable for hemostasis and closure of various tissues.

CN116983467BActive Publication Date: 2026-06-26THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
Filing Date
2023-09-04
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Existing hemostatic materials have problems such as uncertain hemostatic effect, high price, inconvenience of use, and easy to cause infection or rebleeding. In addition, they rely on clotting factors, making it difficult to control bleeding quickly and effectively.

Method used

By using a reasonable ratio of phosphatidylcholine, Soluplus (polyvinylcaprolactam-polyvinyl acetate-polyethylene glycol graft copolymer), polyoxyethylene lauryl ether, polyglycerol ester, etc., a rapid and firm hemostatic seal is formed, achieving in-situ gelation through physicochemical action.

Benefits of technology

It achieves rapid and firm hemostasis, does not rely on thrombin, is simple to operate, has good biocompatibility, is low in cost, and is suitable for hemostasis and closure of various tissues.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application provides a hemostatic liquid auxiliary material and preparation and application thereof. The components of the hemostatic liquid dressing include phosphatidylcholine, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus), polyoxyethylene lauryl ether, polyglycerol ester and an organic solvent, the weight ratio of the phosphatidylcholine, the polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, the polyoxyethylene lauryl ether and the polyglycerol ester in the hemostatic liquid dressing is 35:(5-20):(5-20):(10-30), and the weight percentage of the organic solvent is 10%-20%. Compared with the traditional hemostatic dressing, the application does not rely on the self blood coagulation, and the physical and chemical reactions of the components are synergistically caused with the blood, so that the rapid in-situ gelation at the bleeding site is promoted, the hemostatic effect is obvious, the liquid dressing has the advantages of simple process, low cost and clear effect, and has a good market application prospect.
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