Ganoderma lucidum and schisandra chinensis bidirectional fermentation liquor post-processing process and application

The two-way fermentation broth of Ganoderma lucidum and Schisandra chinensis was processed by plate and frame solid-liquid separation, microfiltration, nanofiltration and three-stage combined membrane filtration. This process solved the concentration polarization problem, improved the permeability and preserved the polysaccharide and tyrosinase inhibition rate. The resulting product has multi-dimensional skin care effects.

CN116999362BActive Publication Date: 2026-06-19HUNAN YUJIA COSMETICS MFG CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUNAN YUJIA COSMETICS MFG CO LTD
Filing Date
2023-08-23
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing fermentation broth post-treatment processes are prone to concentration polarization when processing polysaccharide-rich fungal fermentation broths. This leads to increased solution gel strength, with the gel adhering to the membrane surface, significantly reducing the permeability of active ingredients. Furthermore, traditional ceramic membrane processes cannot effectively retain polysaccharides and tyrosinase inhibition rates.

Method used

The process employs plate and frame solid-liquid separation, microfiltration, nanofiltration, and a three-stage combined membrane filtration process, including a combination of PP membrane, 0.65μm PES membrane, and 0.2μm PES membrane, which are used for preliminary sterilization and impurity removal and further sterilization, respectively. Combined with nanofiltration membrane treatment to reduce conductivity, it ensures the retention of polysaccharides and tyrosinase inhibition rates.

Benefits of technology

The permeability of the fermentation broth was increased to over 80%, while preserving the polysaccharide and tyrosinase inhibition rates. The resulting product can be directly used in skincare products, possessing tyrosinase inhibition, antioxidant, soothing, moisturizing, and anti-inflammatory effects.

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Abstract

This invention provides a post-processing technique for fermentation broth, comprising: A) performing plate-and-frame solid-liquid separation, microfiltration, and nanofiltration on the fermentation broth to obtain filtered fermentation broth; B) sterilizing the filtered fermentation broth by filtration through a combined membrane. The post-processing technique provided by this invention not only preserves polysaccharides as much as possible but also minimizes the loss of tyrosinase inhibition rate; it also effectively solves the permeability problem, and the prepared product can be directly used in skincare products.
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