Sunscreen compositions and uses thereof

Abstract

The present application provides a sunscreen composition and its use, wherein the sunscreen composition comprises titanium dioxide, divalent iron oxide and trivalent iron oxide. By combining titanium dioxide, divalent iron oxide and trivalent iron oxide, the present application can not only adjust different colors of skin, but also has a selective sunscreen effect. Further, the sunscreen composition of the present application can further improve the selectivity of the spectrum, so as to achieve a better spectral selective protection effect.

Description

Technical Field

[0001] This application belongs to the field of cosmetic technology, specifically relating to a sunscreen composition and its use. Background Technology

[0002] As consumers become more aware of photoaging and cosmetic technology continues to advance, sun protection has become an essential step in skincare. Previous research by the inventors revealed that a combination of titanium dioxide and Fe(II) can selectively protect against harmful and beneficial sunlight.

[0003] However, how to achieve a wider range of skin tone toning effects while achieving spectrally selective protection is something that existing technologies have not yet revealed. Summary of the Invention

[0004] The inventors of this application discovered through research that adding toners to products with spectrally selective protection can affect the effectiveness of the protection. Therefore, how to achieve a wider range of toning effects while still maintaining spectrally selective protection is the technical problem this invention aims to solve. To this end, the inventors conducted in-depth research and found that combining titanium dioxide, ferrous oxide, and ferric oxide can solve the above-mentioned technical problem, thus completing this invention.

[0005] Specifically, this application relates to the following aspects:

[0006] 1. A sunscreen composition comprising titanium dioxide, ferrous oxide, and ferric oxide.

[0007] 2. The sunscreen composition according to item 1, wherein the mass ratio of titanium dioxide to ferrous iron is 15:1-2:1, preferably 12:1-3:1.

[0008] 3. The sunscreen composition according to item 1 or 2, wherein the mass ratio of ferrous iron to ferric iron is 1:0.01-1:10, preferably 1:0.01-1:5, and more preferably 1:0.1-1:1.8.

[0009] 4. The sunscreen composition according to any one of items 1-3, wherein the divalent iron oxide is basic ferrous oxide, preferably FeO(OH)·H2O.

[0010] 5. The sunscreen composition according to any one of items 1-4, wherein the trivalent iron oxide is ferric oxide.

[0011] 6. The sunscreen composition according to any one of claims 1-5, wherein the ITA of the sunscreen composition is... o It is 6-42.

[0012] 7. Use of the sunscreen composition according to any one of items 1-6 in cosmetics.

[0013] 8. The use according to item 7, wherein in the cosmetic, the total content of the titanium dioxide, ferrous oxide and ferric oxide is 0.01wt%-50wt%.

[0014] 9. Use of the sunscreen composition according to any one of items 1-6 in improving skin tone.

[0015] 10. Use of the sunscreen composition according to any one of items 1-6 in selective sun protection.

[0016] This application combines titanium dioxide, ferrous oxide, and ferric oxide to achieve both a wider range of color-correcting effects and spectrally selective protection.

[0017] Preferably, this application further improves the spectral selectivity, thereby achieving a better spectral selectivity protection effect. Attached Figure Description

[0018] Figure 1 The transmittance curves of the composition are shown for different mass ratios of TiO2, Fe(II), and Fe(III);

[0019] Figure 2 The transmittance curves of the composition are shown at different mass ratios of TiO2, Fe(II), and CI 15850:1 (or CI 17200). Detailed Implementation

[0020] The present application is further illustrated below with reference to embodiments. It should be understood that the embodiments are only used to further illustrate and explain the present application and are not intended to limit the present application.

[0021] Unless otherwise defined, technical and scientific terms used in this specification have the same meaning as commonly understood by one of ordinary skill in the art. While similar or identical methods and materials may be applied in experimental or practical applications, materials and methods are described herein. In case of conflict, the definitions included herein shall prevail. Furthermore, materials, methods, and examples are for illustrative purposes only and are not intended to be limiting. The present application is further described below with reference to specific embodiments, but is not intended to limit the scope of the application.

[0022] Composition

[0023] One subject matter of this application relates to compositions, which are any compositions capable of achieving the effects described in this application. The "composition" includes, but is not limited to, the simultaneous or sequential use of the components. "Simultaneous use" includes using them together in the same formulation or separately in different formulations. "Sequential use" includes using them sequentially in different formulations, with no restriction on the order of sequential use.

[0024] This application provides a sunscreen composition comprising titanium dioxide, ferrous oxide, and ferric oxide.

[0025] The divalent iron oxide includes various types of ferrous oxides known to those skilled in the art. The trivalent iron oxide includes various types of iron oxides known to those skilled in the art.

[0026] In some specific embodiments, the divalent iron oxide is basic ferrous oxide.

[0027] In some specific embodiments, the divalent iron oxide is FeO(OH)·H2O.

[0028] In some specific embodiments, the trivalent iron oxide is ferric oxide.

[0029] In some specific implementations, the mass ratio of titanium dioxide to divalent iron is 15:1 to 2:1, for example, it can be 15:1, 14:1, 13:1, 12:1, 11:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, and any range between these values.

[0030] In some specific implementations, the mass ratio of titanium dioxide to ferrous iron is 12:1 to 3:1.

[0031] In some specific implementations, the mass ratio of divalent iron to trivalent iron is 1:0.01-1:10, for example, it can be 1:0.01, 1:0.1, 1:0.2, 1:0.3, 1:0.4, 1:0.1, 1:0.2, 1:0.3, 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, 1:1.1, 1:1.2, 1:1.3, 1:1.4, 1:1.5, 1:1.6, 1:1.7, 1:1.8, 1:1.9, 1:2, 1:2.1, 1: 2.2, 1:2.3, 1:2.4, 1:2.5, 1:2.6, 1:2.7, 1:2.8, 1:2.9, 1:3, 1:3.1, 1:3.2, 1:3.3, 1:3.4, 1:3.5, 1:3.6, 1:3.7, 1:3.8, 1:3.9, 1:4, 1:4.1, 1:4.2, 1:4.3, 1:4.4, 1:4.5, 1:4.6, 1:4.7, 1:4.8, 1:4.9, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, and any range between these values.

[0032] In some specific implementations, the mass ratio of ferrous iron to ferric iron is 1:0.01-1:5.

[0033] In some specific implementations, the mass ratio of divalent iron to trivalent iron is 1:0.1 to 1:1.8.

[0034] In some specific embodiments, the ITA of the sunscreen composition o It can be -20 to 45, for example, -18, -16, -14, -12, -10, -8, -6, -4, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, and any range between these values.

[0035] In some specific embodiments, the ITA of the sunscreen composition o The range is 6 to 42.

[0036] ITA o This is a skin color measurement index established using the CIE L*a*b* color space. As shown in Table 1, skin type can be determined based on the ITA. o (individual typology angle) is divided into types I-VI, a total of 6 types (DOI:10.1111 / jdv.17242).

[0037] Table 1

[0038]

[0039] In this application, ITA o It can be determined by three parameters L * a * b * Expressed using a fixed formula, the specific formula is as follows:

[0040] ITA o =ATAN((L * -50) / b * )*180 / PI()).

[0041] Where PI() is the mathematical constant pi; L * a * b * The black and white phase, red and green phase, and yellow and blue phase can be respectively characterized by a spectrophotometer.

[0042] ITA o The larger the range of values, the wider the adjustable color gamut.

[0043] The sunscreen composition of this application has a wide range of ITAs. o The value can be adjusted to different colors, making it suitable for people with different skin tones.

[0044] Furthermore, the sunscreen composition of this application also has selective sun protection effect.

[0045] In some specific embodiments, the selective sun protection factor is 0.6 or higher, preferably 0.7 or higher, and more preferably 0.72-0.95.

[0046] In this application, the selectivity index is defined using the following formula:

[0047]

[0048] Where T is the transmittance of the composition at a certain wavelength;

[0049] λ is the wavelength;

[0050] σ is the integral value of transmittance from 280nm to 760nm.

[0051] A higher selectivity index indicates better selective protection.

[0052] In this application, the sunscreen composition may also contain cosmetically acceptable excipients and other functional ingredients.

[0053] In this application, the sunscreen composition is used in forms including but not limited to water, lotion, cream, spray, powder, gel, etc.

[0054] In this application, no restrictions are placed on the preparation method of the sunscreen composition. It can be prepared according to conventional methods in the art. For example, titanium dioxide, ferrous oxide and ferric oxide can be dissolved in a solvent and ultrasonicated to obtain the sunscreen composition.

[0055] In this application, no restrictions are placed on the solvents used to dissolve titanium dioxide, ferrous oxide, and ferric oxide. These solvents can be commonly used in the art, such as diethylhexyl carbonate, alcohols (e.g., propylene glycol, butanediol, etc.), fatty acid esters (e.g., caprylic / capric fatty acid esters, glyceryl laurate, etc.), silanes (e.g., polysiloxanes, polymethylsiloxanes, etc.), and ethers (e.g., myristyl alcohol polyether, tridecyl alcohol polyether, etc.).

[0056] In some embodiments, the sunscreen composition includes titanium dioxide, ferrous oxide, and ferric oxide, wherein the mass ratio of titanium dioxide to ferrous oxide is 15:1-2:1, and the mass ratio of ferrous oxide to ferric oxide is 1:0.01-1:10.

[0057] In some embodiments, the sunscreen composition includes titanium dioxide, ferrous oxide, and ferric oxide, wherein the mass ratio of titanium dioxide to ferrous oxide is 12:1-3:1, the mass ratio of ferrous oxide to ferric oxide is 1:0.01-1:5, the ferrous oxide is FeO(OH)·H2O, and the ferric oxide is ferric oxide.

[0058] In some embodiments, the sunscreen composition includes titanium dioxide, ferrous oxide, and ferric oxide, wherein the mass ratio of titanium dioxide to ferrous oxide is 12:1-3:1, the mass ratio of ferrous oxide to ferric oxide is 1:0.1-1:1.8, the ferrous oxide is FeO(OH)·H2O, and the ferric oxide is ferric oxide.

[0059] In some embodiments, the sunscreen composition comprises titanium dioxide, ferrous oxide, and ferric oxide, wherein the mass ratio of titanium dioxide to ferrous oxide is 12:1-3:1, the mass ratio of ferrous oxide to ferric oxide is 1:0.1-1:1.8, the ferrous oxide is FeO(OH)·H2O, the ferric oxide is ferric oxide, and the ITA of the sunscreen composition is... o The range is from -20 to 45.

[0060] In some embodiments, the sunscreen composition comprises titanium dioxide, ferrous oxide, ferric oxide, and a solvent, wherein the mass ratio of titanium dioxide to ferrous oxide is 15:1-2:1, and the mass ratio of ferrous oxide to ferric oxide is 1:0.01-1:10. The types of solvents are as described above.

[0061] In some embodiments, the sunscreen composition comprises titanium dioxide, ferrous oxide, ferric oxide, and a solvent, wherein the mass ratio of titanium dioxide to ferrous oxide is 12:1-3:1, the mass ratio of ferrous oxide to ferric oxide is 1:0.01-1:5, the ferrous oxide is FeO(OH)·H2O, and the ferric oxide is ferric oxide. The type of solvent is as described above.

[0062] In some embodiments, the sunscreen composition comprises titanium dioxide, ferrous oxide, ferric oxide, and a solvent, wherein the mass ratio of titanium dioxide to ferrous oxide is 12:1-3:1, the mass ratio of ferrous oxide to ferric oxide is 1:0.1-1:1.8, the ferrous oxide is FeO(OH)·H2O, and the ferric oxide is ferric oxide. The type of solvent is as described above.

[0063] In some embodiments, the sunscreen composition comprises titanium dioxide, ferrous oxide, ferric oxide, and a solvent, wherein the mass ratio of titanium dioxide to ferrous oxide is 12:1-3:1, the mass ratio of ferrous oxide to ferric oxide is 1:0.1-1:1.8, the ferrous oxide is FeO(OH)·H2O, the ferric oxide is ferric oxide, and the ITA of the sunscreen composition is... o The temperature ranges from -20 to 45°C. The types of solvents are as described above.

[0064] use

[0065] Another subject matter of this application relates to use; the term "cosmetics" means a preparation used on the human body for the purpose of beautifying, preserving or altering a person's appearance, or for cleansing, dyeing, rubbing, correcting or protecting the skin. The "cosmetics" involved in this application do not involve any therapeutic effect.

[0066] This application provides the use of any of the above-mentioned sunscreen compositions in cosmetics.

[0067] In some specific embodiments, the total content of titanium dioxide, ferrous oxide, and ferric oxide in the cosmetic is 0.01 wt%-50 wt%, for example, it can be 0.01 wt%, 0.1 wt%, 1 wt%, 2 wt%, 3 wt%, 4 wt%, 5 wt%, 6 wt%, 7 wt%, 8 wt%, 9 wt%, 10 wt%, 11 wt%, 12 wt%, 13 wt%, 14 wt%, 15 wt%, 16 wt%, 17 wt%, 18 wt%, 19 wt%, 20 wt%, 21 wt%, etc. wt%, 22wt%, 23wt%, 24wt%, 25wt%, 26wt%, 27wt%, 28wt%, 29wt%, 30wt%, 31wt%, 32wt%, 33wt%, 34wt%, 35wt%, 36wt%, 37wt%, 38wt%, 39wt%, 40wt%, 41wt%, 42wt%, 43wt%, 44wt%, 45wt%, 46wt%, 47wt%, 48wt%, 49wt%, 50wt%, and any range between these values.

[0068] In some specific embodiments, the titanium dioxide content in the cosmetic is 0.01wt%-30wt%, for example, it can be 0.01wt%, 0.1wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%, 9wt%, 10wt%, 11wt%, 12wt%, 13wt%, 14wt%, 15wt%, 16wt%, 17wt%, 18wt%, 19wt%, 20wt%, 21wt%, 22wt%, 23wt%, 24wt%, 25wt%, 26wt%, 27wt%, 28wt%, 29wt%, or 30wt%.

[0069] In some specific embodiments, the content of the divalent iron oxide in the cosmetic is 0.01wt%-30wt%, for example, it can be 0.01wt%, 0.1wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%, 9wt%, 10wt%, 11wt%, 12wt%, 13wt%, 14wt%, 15wt%, 16wt%, 17wt%, 18wt%, 19wt%, 20wt%, 21wt%, 22wt%, 23wt%, 24wt%, 25wt%, 26wt%, 27wt%, 28wt%, 29wt%, or 30wt%.

[0070] In some specific embodiments, the content of the trivalent iron oxide in the cosmetic is 0.01wt%-30wt%, for example, it can be 0.01wt%, 0.1wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%, 9wt%, 10wt%, 11wt%, 12wt%, 13wt%, 14wt%, 15wt%, 16wt%, 17wt%, 18wt%, 19wt%, 20wt%, 21wt%, 22wt%, 23wt%, 24wt%, 25wt%, 26wt%, 27wt%, 28wt%, 29wt%, or 30wt%.

[0071] This application also provides the use of any of the above-described sunscreen compositions in improving skin tone.

[0072] This application also provides the use of any of the above-described sunscreen compositions in selective sun protection.

[0073] Example

[0074] This application provides a general and / or specific description of the materials and test methods used in the experiments. In the following examples, unless otherwise specified, % represents wt%, i.e., weight percentage. Reagents or instruments used, unless otherwise specified, are all commercially available conventional reagent products. The raw materials and equipment used in the examples and comparative examples are shown in Table 2.

[0075] Table 2

[0076]

[0077] Preparation Example 1

[0078] Weigh out the corresponding masses of TiO2, FeO(OH)·H2O and Fe2O3 powders respectively, dissolve them in 10 ml of diethylhexyl carbonate, and sonicate at 25℃ and 40 kHz for 5 min until the sample is completely dispersed to obtain the sunscreen composition, which is numbered 1-18 in Table 3.

[0079] Preparation Example 2

[0080] Weigh out the corresponding masses of TiO2, FeO(OH)·H2O and CI 15850:1 powder respectively, dissolve them in 10 ml of diethylhexyl carbonate, and sonicate at 25℃ and 40 kHz for 5 min until the sample is completely dispersed to obtain the sunscreen composition, which is numbered 19-22 in Table 4.

[0081] Preparation Example 3

[0082] Weigh out the corresponding amounts of TiO2, FeO(OH)·H2O and CI 17200 powders respectively, dissolve them in 10 ml of diethylhexyl carbonate, and sonicate at 25℃ and 40 kHz for 5 min until the sample is completely dispersed to obtain the sunscreen composition, which is numbered 23-26 in Table 5.

[0083] Table 3

[0084]

[0085] Table 4

[0086]

[0087] Table 5

[0088]

[0089] Experimental Example 1: Determination of Selectivity Index

[0090] The sunscreen composition prepared in the preparation example was diluted, and 300 μL of the diluted sample solution was placed in a cuvette. The transmittance was measured in different wavelength ranges, and the results are as follows. Figure 1 and Figure 2 As shown. Among them. Figure 1 The results are for compositions 1-15. Figure 2 The results are for compositions 19-26.

[0091] Based on the transmittance of the sunscreen composition of the preparation example at wavelengths of 280-760 nm, the selectivity index was calculated according to the following formula, and the results are shown in Tables 3-5.

[0092]

[0093] Where T is the transmittance of the composition at a certain wavelength;

[0094] λ is the wavelength;

[0095] σ is the integral value of transmittance from 280nm to 760nm.

[0096] Test Example 2: ITA Measurement o value

[0097] Take 3 ml of the sunscreen composition sample prepared in the preparation example and measure L using a spectrophotometer. * a * b * Value, ITA o It can be determined by three parameters L * a * b * Expressed using a fixed formula, the specific formula is as follows:

[0098] ITA o =ATAN((L * -50) / b * )*180 / PI()).

[0099] Where PI() is the value of pi;

[0100] L * a * b * These represent the black and white, red and green, and yellow and blue hues, respectively. The L* value is influenced by the content of melanin and sebum. * The value is regulated by hemoglobin content and blood microcirculation, b * The value is affected by factors such as the content of collagen and lipofuscin.

[0101] ITA measured o The results are shown in Tables 3-5.

Claims

1. A sunscreen composition comprising titanium dioxide, FeO(OH)·H2O and ferric oxide, wherein the mass ratio of iron in FeO(OH)·H2O to iron in ferric oxide is 1:0.05-1:1.8; The mass ratio of titanium dioxide to iron in FeO(OH)·H2O is 13:1-2:

1.

2. The sunscreen composition according to claim 1, wherein the mass ratio of titanium dioxide to iron in FeO(OH)·H2O is 12:1-3:

1.

3. The sunscreen composition according to claim 1, wherein the mass ratio of iron in FeO(OH)·H2O to iron in ferric oxide is 1:0.1-1:1.

8.

4. Use of the sunscreen composition according to any one of claims 1-3 in the preparation of cosmetics.

5. The use according to claim 4, wherein in the cosmetic, the total content of titanium dioxide, FeO(OH)·H2O and ferric oxide is 0.01wt%-50wt%.

6. Use of the sunscreen composition according to any one of claims 1-3 in the preparation of a product for improving skin tone.

7. Use of the sunscreen composition according to any one of claims 1-3 in the preparation of a selective sunscreen product.

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