A composition with skin anti-allergic care effect and application thereof

Abstract

The present application relates to a kind of compositions with skin anti-allergic repair effect and its application, and the composition with skin anti-allergic repair effect includes oat kernel extract, fuzi extract, ceramide, radix paeonia extract and fibronectin.The oat kernel extract, fuzi extract, ceramide, radix paeonia extract and fibronectin of the present application are combined into a kind of new composition, and the composition has unpredictable synergistic effect on eliminating skin fever redness, inhibiting the release of inflammatory factors, repairing the barrier of stratum corneum and preventing skin allergic effect.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of cosmetics, and particularly relates to a composition with skin anti-allergy repair efficacy and application thereof, and especially relates to a composition with skin anti-allergy repair efficacy and application thereof in the preparation of cosmetics. BACKGROUND

[0002] With the rapid development of the economic society, the living standards of residents are improved, and at the same time, some skin problems occur due to living environment and life pressure. The survey of Chinese people's skin status released by the Dermatology Branch of the Chinese Medical Association shows that as high as 72.08% of the population is in a sub-healthy skin state. The data of the Chinese Journal of Dermato-venereology Expert Consensus on Diagnosis and Treatment of Sensitive Skin also shows that 40% to 56% of Asian women are sensitive skin, and more than 35% of women in China belong to the sensitive skin population. Sensitive skin is often accompanied by symptoms of skin allergy, and skin allergy is a very common form of allergy in the human body, and 20% of people have skin allergy. Skin allergy is also called allergic skin. A big feature of allergic skin is itching. From a medical point of view, skin allergy mainly refers to the stimulation of the skin by adverse reaction cosmetics, chemicals, pollen, some foods, polluted air and other media, resulting in skin allergy symptoms such as redness, itching, peeling and allergic dermatitis.

[0003] At present, the primary way for the skin allergy population to have skin allergy symptoms is to find a doctor to solve the problem. The doctor will generally prescribe some oral anti-allergy drugs combined with corticosteroid ointments for the patient to use. This type of ointment has a quick effect and can immediately solve the symptoms of allergy. However, if the consumer uses such ointments for a long time, it will develop into hormone-dependent dermatitis, which will make the skin worse and worse. Another part of the consumers will use anti-allergy soothing cosmetics. Many of these cosmetics only inhibit some symptoms of allergy, such as simple antihistamines and inhibition of interleukins. These products may only be effective for some consumers and are not suitable for most allergy populations. In addition to the release of inflammatory factors, the allergy population is often accompanied by symptoms such as redness, pain and burning of the skin. SUMMARY

[0004] In view of the deficiencies of the prior art, the purpose of the present application is to provide a composition with skin anti-allergy repair efficacy and application thereof, and especially to provide a composition with skin anti-allergy repair efficacy and application thereof in the preparation of cosmetics.

[0005] To achieve this purpose, the present application adopts the following technical solutions:

[0006] In a first aspect, the present application provides a composition having skin anti-allergic care effect, the composition having skin anti-allergic care effect comprising oat kernel extract, rhizoma corydalis extract, ceramide, radix paeonia extract and fibronectin.

[0007] The present application creatively combines oat kernel extract, rhizoma corydalis extract, ceramide, radix paeonia extract and fibronectin into a brand new composition, the five ingredients have potential mutual promotion, and have unpredictable synergistic effect on eliminating skin heat and redness, inhibiting release of inflammatory factors, repairing barrier of stratum corneum and preventing skin allergic effect.

[0008] Oat kernel extract is an active ingredient derived from oat kernel, which can inhibit release of IL-6 and IL-8 by inhibiting activation of NF-κB, and can resist histamine, thus having rapid anti-inflammatory and anti-itching activity and anti-erythema activity. The unconventional oat alkaloid used in the composition of the present application is water-soluble, which can be conveniently added to water-based products, and is very stable after water-solubility treatment, without discoloration, and has more excellent anti-allergic and anti-itching effect.

[0009] Rhizoma corydalis extract can regulate activity of TRPV1 nerve receptor, quickly restore calcium flux to normal level, so as to reduce burning and pain of skin, and thus reduce skin allergic symptoms.

[0010] Ceramide is a kind of amide compound formed by dehydration of amino group of long-chain fatty acid and sphingosine, mainly including ceramide phosphocholine and ceramide phosphoethanolamine. Phospholipid is the main component of cell membrane, and 40% to 50% of sebum in stratum corneum is composed of ceramide. Ceramide is the main part of intercellular matrix, and plays an important role in maintaining water balance of stratum corneum. Ceramide has strong ability to associate with water molecules, and it maintains skin moisture by forming a network structure in stratum corneum. Therefore, ceramide has the effect of maintaining skin moisture. Ceramide exists in all eukaryotic cells, and has important regulation effect on cell differentiation, proliferation, apoptosis and aging. As the main component of intercellular lipid in skin stratum corneum, ceramide not only acts as a second messenger molecule in sphingomyelin pathway, but also plays an important role in the process of epidermal stratum corneum formation, and has the effects of maintaining skin barrier, moisturizing, anti-aging, whitening and disease treatment.

[0011] Paeonia extract is an effective component extracted from the dried root bark of Paeonia suffruticosa or Paeonia lactiflora or the whole plant of Gelsemium elegans, and is a small molecule phenolic compound. The paeonia extract has the following three effects: (1) analgesic effect on physical or chemical pain; (2) anti-inflammatory effect on inflammation caused by related substances such as histamine, 5-hydroxytryptamine, bradykinin and botulinum toxin; and (3) whitening effect due to the ability to reduce inflammation-induced pigmentation.

[0012] Fibronectin is a high molecular weight glycoprotein widely present in tissues and interstitial fluid, and plays an important role in promoting cell adhesion, migration, growth, proliferation and differentiation. Fibronectin is composed of two peptide chains and has six functional regions, which are combined with collagen, heparin, cells, fibers and the like, has the biological function of cell regeneration and repair, and has the effect of stimulating fibroblasts to grow and proliferate in large quantities, thereby secreting hyaluronic acid, collagen, elastin and elastic fibers, and reticular fibers, so as to make the skin barrier function more perfect.

[0013] Preferably, the composition with skin anti-allergy care effect comprises, in parts by weight: oat kernel extract 0.05-0.5 parts, Corydalis extract 0.2-1 part, ceramide 1-5 parts, paeonia extract 0.1-0.5 parts and fibronectin 0.5-5 parts.

[0014] When the five components in the composition with skin anti-allergy care effect are combined in the above specific weight ratio, the effect of eliminating skin heat and swelling, inhibiting the release of inflammatory factors, repairing the barrier of stratum corneum and preventing skin allergy can be maximized.

[0015] The parts by weight of the oat kernel extract can be 0.05 parts, 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, etc.; the parts by weight of the Corydalis extract can be 0.2 parts, 0.3 parts, 0.5 parts, 0.7 parts, 1.0 parts, etc.; the parts by weight of the ceramide can be 1 part, 2 parts, 3 parts, 4 parts, 4.5 parts, 5 parts, etc.; the parts by weight of the paeonia extract can be 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, etc.; and the parts by weight of the fibronectin can be 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 4.5 parts, 5 parts, etc. Other point values within the above numerical range can also be selected, which will not be described here.

[0016] In a second aspect, the present application provides the use of the composition with skin anti-allergy care effect of the first aspect in the preparation of cosmetics.

[0017] Preferably, the composition having skin anti-allergy care effect according to the first aspect has a mass percentage content of 1.5% to 15% in the cosmetic, for example 1.5%, 2%, 3%, 4%, 5%, 6%, 7%, 10%, 12%, 14%, 15%, etc. Other specific point values within the above numerical range can be selected, which are not listed here.

[0018] In the third aspect, the present application provides a serum having skin anti-allergy care effect, and the preparation raw materials of the serum having skin anti-allergy care effect include the composition having skin anti-allergy care effect according to the first aspect, a humectant, a thickening agent, an emollient, a skin conditioning agent, and water.

[0019] The composition according to the present application can be further prepared into a cosmetic product such as a serum, which also has good skin anti-allergy care effect and is mild and non-irritating to the skin.

[0020] Preferably, the skin conditioning agent includes any one or a combination of at least two of glycyrrhetinic acid, octanoyl glycine, dipotassium glycyrrhizinate, vitamin E, pantothenic acid, or pyridoxine. The combination of at least two includes a combination of glycyrrhetinic acid and octanoyl glycine, a combination of octanoyl glycine and dipotassium glycyrrhizinate, a combination of dipotassium glycyrrhizinate and vitamin E, etc., and other any combination mode can be selected, which are not listed here.

[0021] Further preferably, the skin conditioning agent includes any one or a combination of at least two of vitamin E, pantothenic acid, or pyridoxine; preferably a combination of vitamin E, pantothenic acid, and pyridoxine.

[0022] The present application selects the combination of vitamin E, pantothenic acid, and pyridoxine as the skin conditioning agent of the serum, which has better cooperation effect in combination with the above composition and has more remarkable effect in skin anti-allergy care.

[0023] Preferably, the emollient includes any one or a combination of at least two of cetyl alcohol ethylhexanoate, squalane, isooctyl palmitate, isopropyl myristate, or cyclomethicone. The combination of at least two includes a combination of cetyl alcohol ethylhexanoate and squalane, a combination of squalane and isooctyl palmitate, a combination of isooctyl palmitate and isopropyl myristate, etc., and other any combination mode can be selected, which are not listed here.

[0024] In the fourth aspect, the present application provides a preparation method of the serum having skin anti-allergy care effect according to the third aspect, and the preparation method includes:

[0025] (1) mixing an emollient, a thickening agent, a skin conditioning agent, water, and part of a humectant to obtain a base composition; mixing the composition having skin anti-allergy care effect and the remaining humectant to obtain an effect composition;

[0026] (2) mixing the matrix composition and the efficacy composition obtained in step (1) to obtain the serum having the skin anti-allergy care efficacy.

[0027] Preferably, the mixing in step (1) for preparing the matrix composition means stirring at 60-70℃ (for example 60℃, 61℃, 62℃, 63℃, 64℃, 65℃, 66℃, 67℃, 68℃, 69℃, 70℃, etc.) for 10-30min (for example 10min, 15min, 17min, 20min, 23min, 25min, 28min, 30min, etc.). Other specific point values within the above numerical range can be selected, which are not listed one by one here.

[0028] Preferably, the mixing in step (1) for preparing the efficacy composition means stirring at 15-40℃ (for example 15℃, 20℃, 25℃, 30℃, 35℃, 40℃, etc.) for 10-15min (for example 10min, 11min, 12min, 13min, 14min, 15min, etc.). Other specific point values within the above numerical range can be selected, which are not listed one by one here.

[0029] Preferably, the mixing in step (2) means stirring at 15-40℃ (for example 15℃, 20℃, 25℃, 30℃, 35℃, 40℃, etc.) for 10-15min (for example 10min, 11min, 12min, 13min, 14min, 15min, etc.). Other specific point values within the above numerical range can be selected, which are not listed one by one here.

[0030] The preparation method of the serum having the skin anti-allergy care efficacy according to the present application can ensure the stability of the product system, prevent the product from delaminating, discoloring, and becoming coarse, and ensure the durability of the product efficacy when the specific process parameters are combined.

[0031] Compared with the prior art, the present application has the following beneficial effects:

[0032] The oat kernel extract, the corydalis extract, the ceramide, the peony root extract, and the fibronectin are combined into a new composition, and the five components have potential mutual promotion effects, and have unpredictable synergistic effects on eliminating skin heat and redness, inhibiting the release of inflammatory factors, repairing the barrier of the stratum corneum, and preventing skin allergy. BRIEF DESCRIPTION OF DRAWINGS

[0033] Figure 1 is a skin muscle base redness map of subject 1 before using the serum having the skin anti-allergy care efficacy in application example 1;

[0034] Figure 2 is a skin basal redness map of subject 1 before using the serum with skin anti-irritation care efficacy in application example 1 for four weeks;

[0035] Figure 3 is a skin basal redness map of subject 2 before using the serum with skin anti-irritation care efficacy in application example 1 ;

[0036] Figure 4 is a skin basal redness map of subject 2 after using the serum with skin anti-irritation care efficacy in application example 1 for four weeks;

[0037] Figure 5 is a skin basal redness map of subject before using the serum with skin anti-irritation care efficacy in application example 2;

[0038] Figure 6 is a skin basal redness map of subject after using the serum with skin anti-irritation care efficacy in application example 2 for four weeks;

[0039] Figure 7 is a skin basal redness map of subject before using the serum with skin anti-irritation care efficacy in application example 3;

[0040] Figure 8 is a skin basal redness map of subject after using the serum with skin anti-irritation care efficacy in application example 3 for four weeks;

[0041] Figure 9 is a skin basal redness map of subject before using the serum with skin anti-irritation care efficacy in application example 4;

[0042] Figure 10 is a skin basal redness map of subject after using the serum with skin anti-irritation care efficacy in application example 4 for four weeks; DETAILED DESCRIPTION

[0043] The technical solutions of the present application will be further described below in conjunction with the accompanying drawings and through specific embodiments. Those skilled in the art should understand that the embodiments are only to help understand the present application and should not be regarded as specific limitations of the present application.

[0044] Some components in the following examples and comparative examples are from the following sources:

[0045] The weight fractions of oat kernel extract, corydalis extract, ceramide, paeonia extract and fibronectin referred to below are all based on the actual efficacy component content in the commercially available raw materials, which also selectively contain any one or a combination of at least two of solvents, fillers, diluents, stabilizers, pH regulators, antibacterial agents, antioxidants or impurities within the permissible range.

[0046] The oat kernel extract involved in the following examples, comparative examples, application examples and comparative application examples is derived from the product with the model of oat kernel extract purchased from Fanlin Chemical Technology (Guangzhou) Co., Ltd.; the fibronectin is derived from the product with the model of fibronectin purchased from Tianjin Hongshunke Biological Technology Co., Ltd.; the extract of Corydalis is derived from the product with the model of extract of Corydalis purchased from Tianjin Hongshunke Biological Technology Co., Ltd.; the extract of peony root is derived from the product with the model of extract of peony root purchased from Xi'an Tianfeng Biological Technology Co., Ltd.; the pyridoxine is derived from the product with the model of P9755 purchased from Merck Chemical Technology (Shanghai) Co., Ltd.; the pantothenic acid is derived from the product with the model of C8731 purchased from Merck Chemical Technology (Shanghai) Co., Ltd.; the dipotassium glycyrrhizinate is derived from the product with the model of dipotassium glycyrrhizinate purchased from Gansu Fanyi Pharmaceutical Co., Ltd.; and the oligopeptide-1 is derived from the product with the model of oligopeptide-1 purchased from Sichuan Jisheng Biological Medicine Co., Ltd.

[0047] Example 1

[0048] The present example provides a composition with skin anti-allergy care effect, which is composed of 0.5 parts of oat kernel extract, 1 part of extract of Corydalis, 5 parts of ceramide, 0.5 part of extract of peony root and 5 parts of fibronectin. The preparation method is to mix the commercially available raw material products uniformly.

[0049] Example 2

[0050] The present example provides a composition with skin anti-allergy care effect, which is composed of 0.25 parts of oat kernel extract, 0.6 part of extract of Corydalis, 3 parts of ceramide, 0.25 part of extract of peony root and 2.5 parts of fibronectin. The preparation method is to mix the commercially available raw material products uniformly.

[0051] Example 3

[0052] The present example provides a composition with skin anti-allergy care effect, which is composed of 0.05 parts of oat kernel extract, 0.2 part of extract of Corydalis, 1 part of ceramide, 0.25 part of extract of peony root and 0.5 parts of fibronectin. The preparation method is to mix the commercially available raw material products uniformly.

[0053] Comparative Example 1

[0054] The present comparative example provides a composition, which is composed of 1 part of extract of Corydalis, 5 parts of ceramide, 0.5 part of extract of peony root and 5 parts of fibronectin. The preparation method is to mix the commercially available raw material products uniformly.

[0055] Comparative Example 2

[0056] This comparative example provides a composition consisting of oat kernel extract 0.5 parts, ceramide 5 parts, peony root extract 0.5 parts, and fibronectin 5 parts. The preparation method is to mix the commercially available raw material products uniformly.

[0057] Comparative Example 3

[0058] This comparative example provides a composition consisting of oat kernel extract 0.5 parts, Corydalis extract 1 part, peony root extract 0.5 parts, and fibronectin 5 parts. The preparation method is to mix the commercially available raw material products uniformly.

[0059] Comparative Example 4

[0060] This comparative example provides a composition consisting of oat kernel extract 0.5 parts, Corydalis extract 1 part, ceramide 5 parts, and fibronectin 5 parts. The preparation method is to mix the commercially available raw material products uniformly.

[0061] Comparative Example 5

[0062] This comparative example provides a composition consisting of oat kernel extract 0.5 parts, Corydalis extract 1 part, ceramide 5 parts, and peony root extract 0.5 parts. The preparation method is to mix the commercially available raw material products uniformly.

[0063] Comparative Example 6

[0064] This comparative example provides a single oat kernel extract.

[0065] Comparative Example 7

[0066] This comparative example provides a single Corydalis extract.

[0067] Comparative Example 8

[0068] This comparative example provides a single ceramide.

[0069] Comparative Example 9

[0070] This comparative example provides a single peony root extract.

[0071] Comparative Example 10

[0072] This comparative example provides a single fibronectin.

[0073] Application Example 1

[0074] This application example provides a serum with skin anti-allergy care efficacy, whose formula is as follows:

[0075]

[0076]

[0077] The preparation method is as follows:

[0078] (1) Cetyl alcohol ethylhexanoate, squalane, acrylates / C10-30 alkyl acrylate crosspolymer, vitamin E, pyridoxine, EDTA-2Na, Tween 20, pantothenic acid and water are mixed, stirred at 70°C for 15 min to obtain a base composition; oat kernel extract, rhizoma corydalis extract, ceramide, radix paeonia extract and fibronectin are mixed with glycerol, butanediol, arginine (10% aqueous solution) at 25°C for 10 min to obtain an efficacy composition;

[0079] (2) The base composition and the efficacy composition obtained in step (1) are mixed, stirred at 25°C for 15 min to obtain the serum with skin anti-allergy care efficacy.

[0080] Application Example 2-3

[0081] This application example provides two serums with skin anti-allergy care efficacy, the difference between the raw materials for preparation and application example 1 is only that the composition of example 1 is replaced by the composition of example 2-3 with the same amount of addition, and other conditions remain unchanged. The preparation method is referred to application example 1.

[0082] Application Example 4

[0083] This application example provides a serum with skin anti-allergy care efficacy, the difference between the raw materials for preparation and application example 1 is only that the skin conditioner in this application example is 0.6% vitamin E, and other conditions remain unchanged. The preparation method is referred to application example 1.

[0084] Application Example 5

[0085] This application example provides a serum with skin anti-allergy care efficacy, the difference between the raw materials for preparation and application example 1 is only that the skin conditioner in this application example is 0.3% vitamin E and 0.3% pantothenic acid, and other conditions remain unchanged. The preparation method is referred to application example 1.

[0086] Application Example 6

[0087] This application example provides a serum with skin anti-allergy care efficacy, the difference between the raw materials for preparation and application example 1 is only that the skin conditioner in this application example is 0.3% vitamin E and 0.3% pyridoxine, and other conditions remain unchanged. The preparation method is referred to application example 1.

[0088] Comparative Application Example 1

[0089] The present comparative application provides a serum with skin anti-allergy care efficacy, which is prepared from the raw materials as in application example 1 except that the present comparative application does not contain vitamin E, pantothenic acid and pyridoxine, the reduced amount of which is proportionally reduced into water. The preparation method is as in application example 1.

[0090] Comparative application examples 2-11

[0091] The present comparative application provides 10 kinds of serum, which are prepared from the raw materials as in application example 1 except that the efficacy composition of example 1 is respectively replaced by the same amount of products of comparative examples 1-10, and other conditions remain unchanged. The preparation method is as in application example 1.

[0092] Comparative application example 12

[0093] The present comparative application provides a commercially available skin anti-allergy care serum.

[0094] Comparative application example 13

[0095] The present comparative application provides a serum with skin anti-allergy care efficacy, which is prepared from the raw materials as in application example 1 except that the efficacy composition of example 1 is replaced by the same amount of glycyrrhizic acid disodium salt, and other conditions remain unchanged. The preparation method is as in application example 1.

[0096] Comparative application example 14

[0097] The present comparative application provides a serum with skin anti-allergy care efficacy, which is prepared from the raw materials as in application example 1 except that the efficacy composition of example 1 is replaced by the same amount of oligopeptide-1, and other conditions remain unchanged. The preparation method is as in application example 1.

[0098] Test example 1

[0099] Skin safety test:

[0100] The serum products with efficacy prepared from application examples 1-6 and comparative application examples 1-14 are placed in patch testers, and the patch testers with the test substances are attached to the flexor side of the forearms of test subjects (40 in total), 20 application points per test subject, and the skin is evenly attached by gently pressing with the palm for 24 hours; the skin irritation and sensitization are observed 30 min, 24 h and 48 h after the removal of the patch testers with the test substances according to table 1 (skin reaction grading standard for skin occlusive patch test), and the observation results are recorded.

[0101] Table 1

[0102]

[0103] The results are shown in Table 2. The skin reaction grade of Comparative Example 12 is 1, indicating that it has slight irritation. The serums of Application Examples 1-6, Comparative Application Examples 2-11, 13-14 do not cause irritation, indicating that the skin anti-allergy care composition and the serum involved in the present application are safe and non-irritating to the skin.

[0104] Test Example 2

[0105] Skin redness alleviating effect test

[0106] Test samples: Application Examples 1-6 and Comparative Application Examples 1-14;

[0107] Test population: 60 volunteers (18-55 years old, male and female);

[0108] Test site: face;

[0109] Test instrument: Media Cybernetics Image-Pro Plus 7.0;

[0110] Test method: 50 μL of 10% lactic acid solution was applied to filter paper (diameter about 0.8 cm) on both sides of the nasolabial folds of the test personnel at the same time, and when the test personnel felt the irritation score reached ≥2 points (irritation endpoint), the filter paper was removed. The test sample was applied to both test areas at the same time, and the amount of sample applied to each area was 0.1 mL. The VISIA image analysis system was used to collect images of the facial skin of the test subject, and the a* value of the skin before and 30 min after the use of the test sample was tested using Media Cybernetics Image-Pro Plus 7.0. The a* value is an index representing the redness of the skin, and the greater the a* value, the more serious the skin redness. The average change rate of the skin a* value is shown in Table 4. The average change rate of the a* value (%) = (data after use-data before use) / data before use x 100%.

[0111] Table 2

[0112]

[0113]

[0114] As can be seen from Table 2, the composition involved in the present application and the cosmetic product containing the same have excellent effects in alleviating skin redness. Compared with Comparative Application Examples 1-14, Application Example 1 has better redness alleviating effect on redness caused by lactic acid irritation, indicating that oat kernel extract, Corydalis extract, ceramide, radix paeonia extract and fibronectin have a synergistic effect in the above-mentioned effects. The addition of skin conditioning agents can further alleviate skin redness, and there is also a synergistic effect between vitamin E, pantothenic acid and pyridoxine.

[0115] Test Example 3

[0116] Test of relieving skin sensitivity

[0117] Test samples: application examples 1-6, comparative application examples 1-14;

[0118] Test population: 60 volunteers (18-55 years old, male and female);

[0119] Test site: 8 areas on the back of the volunteer were randomly selected;

[0120] Test method: the test sample was used twice a day for 5 consecutive days, and the skin hemoglobin of the test area was measured by using the skin hemoglobin tester Mexameter (MX18, Courage and Khazaka, Germany) before using the sample after the model was established (D0), 1, 2, 3, 4 and 5 days after using the sample (D1-D5). The skin hemoglobin test results before use (D0), 1 day after use (D1), 2 days after use (D2), 3 days after use (D3), 4 days after use (D4) and 5 days after use (D5) are shown in Table 5. The greater the skin hemoglobin index EI value, the higher the skin hemoglobin content.

[0121] Table 3

[0122]

[0123]

[0124] As can be seen from Table 4, the composition and the cosmetic product containing the same involved in the application have excellent effects in relieving skin sensitivity and reducing the degree of skin redness. Compared with comparative application examples 1-14, the hemoglobin index EI value of application example 1 has a greater reduction rate, which indicates that the serum of the application can significantly reduce the hemoglobin content of the test area, effectively relieve the redness symptoms of sensitive skin in a short period of time, and the oat kernel extract, the Corydalis extract, the ceramide, the peony root extract and the fibronectin have a synergistic effect in the above-mentioned effects. The addition of the skin conditioner can further relieve skin sensitivity and reduce the degree of skin redness, and there is also a synergistic effect between vitamin E, pantothenic acid and pyridoxine.

[0125] Test Example 4

[0126] Table 4

[0127]

[0128] The test example uses a Finnish Delfin VapoMeter SWL5201 transdermal water loss measuring instrument. The VapoMeter uses a closed cavity measurement principle, so the measurement is not affected by indoor air flow, the measurement time is short, and the minimization of blocking normal evaporation is ensured. The Finnish Delfin Antera 3D camera is used. The Antera 3D can measure the texture, smoothness, and depth and width of fine lines and wrinkles of the skin. With its multi-spectral analysis, the Antera software can also measure pigmentation and redness, providing meaningful information about sun damage, striae, etc.

[0129] The experimental principle is to test the TEWL value. Transepidermal water loss (TEWL) measures the change in water vapor pressure adjacent to the skin surface. The TEWL value represents the condition of water loss in the stratum corneum, and is an important standard for evaluating the barrier function of the stratum corneum. The lower the TEWL value of the skin, the better the barrier function of the skin, and vice versa. The value of skin moisture loss TEWL can be used to evaluate the efficacy of moisturizing and repairing cosmetics, and can also be applied to allergic patch tests, contact dermatitis, physical therapy, burn and new tissue monitoring, and timely detection of whether the protective function of the skin has been damaged. The unit of TEWL is g / hm 2 .

[0130] In this experiment, 100 subjects were divided into 20 groups, and each group of subjects applied the same amount of the serum of the application examples 1-6 and the comparative application examples 1-14. Each group of subjects applied the serum to the face twice a day for 4 weeks, and recorded the TEWL value. Then, the Antera 3D camera was used to take pictures of each volunteer's face, and the pictures were archived.

[0131] In this test, the TEWL value measured before the subjects used the serum of the above application examples and comparative application examples was set as TEWL0, and the TEWL value at the 4th week was set as TEWL4. The change in TEWL value was ΔTEWL, ΔTEWL = TEWL4-TEWL0. ΔTEWL was negative, and the lower the value, the less the water loss of the skin after four weeks, that is, the better the repair of the skin barrier function, the healthier the skin, and the change rate of ΔTEWL = ΔTEWL / TEWL0. Table 2 shows the average ΔTEWL change rate value of each group of 20 people.

[0132] As shown in Table 5, the composition and serum with skin anti-allergy repair effect involved in the present application have excellent effects of eliminating skin heat and swelling, inhibiting the release of inflammatory factors, repairing the barrier of the stratum corneum, and preventing skin allergy. The oat kernel extract, corydalis extract, ceramide, radix paeonia extract, and fibronectin have the best synergistic effect on improving the skin anti-allergy repair effect of the product at the proportion of the composition of Example 1. Figures 1-4As shown, the skin quality of the subject using the essence of application example 1 was significantly improved compared to four weeks ago, and the skin condition was improved Figures 5-10 As shown, the skin of the subjects after using application examples 2-3 and application example 4 was also improved, but the improvement effect was poorer than that of application example 1, which further proves that the skin anti-allergy care effect of the essence containing the composition in a certain proportion is the best. The addition of the skin conditioner further promotes the skin anti-allergy care effect, and the combination of vitamin E, pantothenic acid and pyridoxine also affects the whitening effect of the product. When vitamin E, pantothenic acid and pyridoxine are used simultaneously in a certain proportion, they can synergistically assist the effect of the composition with skin anti-allergy care in the present application, further promote the anti-allergy care effect, improve the skin, and regulate the state of the skin, and have the effect of maximizing the promotion of anti-allergy care.

[0133] Table 5

[0134]

[0135]

[0136] The applicant declares that the present application is illustrated by the above examples to explain the detailed process flow of the present application, but the present application is not limited to the above detailed process flow, that is, it does not mean that the present application must rely on the above detailed process flow to be implemented. Those skilled in the art should understand that any improvement of the present application, equivalent replacement of each raw material of the product of the present application, addition of auxiliary ingredients, selection of specific modes, etc. fall within the scope of protection and disclosure of the present application.

Claims

1. A composition with skin anti-allergy and repairing effects, characterized in that, The composition with skin anti-allergy care effect comprises, in parts by weight, 0.05-0.5 parts of oat kernel extract, 0.2-1 parts of rhizoma corydalis extract, 1-5 parts of ceramide, 0.1-0.5 parts of radix paeonia extract, and 0.5-5 parts of fibronectin.

2. Use of the composition with skin anti-allergy care effect according to claim 1 in the preparation of a cosmetic product.

3. Use according to claim 2, characterized in that, The composition with skin anti-allergy care effect has a mass percentage content of 1.5%-15% in the cosmetic product.

4. An essence having skin anti-allergic care effect, characterized by, The preparation raw materials of the serum with skin anti-allergy care effect comprise the composition with skin anti-allergy care effect according to claim 1, a humectant, a thickening agent, an emollient, a skin conditioning agent, and water.

5. The serum with skin anti-allergy and repairing effects according to claim 4, characterized in that, The skin conditioning agent comprises any one or a combination of at least two of glycyrrhizinate, capryloyl glycine, dipotassium glycyrrhizinate, vitamin E, pantothenic acid, or pyridoxine.

6. The serum having skin anti-allergy care efficacy according to claim 5, wherein the serum is a serum for skin care. The skin conditioning agent comprises any one or a combination of at least two of vitamin E, pantothenic acid, or pyridoxine.

7. The serum having skin anti-allergy care efficacy according to claim 6, wherein the serum is a serum for skin care. The skin conditioning agent is a combination of vitamin E, pantothenic acid, and pyridoxine.

8. The serum having skin anti-allergy care efficacy according to claim 4, wherein the serum is a serum for skin care. The emollient comprises any one or a combination of at least two of cetyl alcohol ethylhexanoate, squalane, isooctyl palmitate, isopropyl myristate, or cyclomethicone.

9. The method of preparing the serum having skin anti-allergic care efficacy according to any one of claims 4 to 8, wherein the method is characterized by, The preparation method comprises: (1) mixing an emollient, a thickening agent, a skin conditioning agent, water, and part of a humectant to obtain a base composition; mixing the composition with skin anti-allergy care effect and the remaining humectant to obtain an efficacy composition; (2) mixing the base composition and the efficacy composition obtained in step (1) to obtain the serum with skin anti-allergy care effect.

10. The method of claim 9, wherein the serum having skin anti-allergy care effect is prepared by adding 0.01 to 5% of the extract of claim 1 to a cosmetic base. 10 In step (1) for preparing the base composition, the mixing refers to stirring at 60-70℃ for 10-30 min.

11. The method for preparing the serum with skin anti-allergy and repair effects according to claim 9, characterized in that, In step (1) for preparing the efficacy composition, the mixing refers to stirring at 15-40℃ for 10-15 min.

12. The method for preparing the serum with skin anti-allergy and repair effects according to claim 9, characterized in that, In step (2), the mixing refers to stirring at 15-40℃ for 10-15 min.

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