A multi-effect oral care composition with excellent taste and its application

Abstract

This invention belongs to the technical field of oral care products, specifically relating to a multi-effect oral care composition with excellent taste and its application. The multi-effect oral care composition with excellent taste comprises sophorolipids, zinc ions, and glycyrrhizic acid or its salts in a weight ratio of 0.01-10:0.01-1:0.01-7. Glycyrrhizic acid or its salts have antibacterial, anti-inflammatory, and anti-ulcer effects; zinc salts can effectively inhibit pathogenic bacteria and alleviate gum problems. However, the combined use of these two in aqueous solutions results in significant precipitation problems, leading to substandard sensory indicators in the aqueous products. This technical solution solves the problems associated with simultaneously adding glycyrrhizic acid (salt) and zinc salts by adding sophorolipids, effectively ensuring that the efficacy of zinc salts and glycyrrhizic acid or its salts is fully realized, and sophorolipids themselves have antibacterial properties. This composition has significant efficacy and excellent taste, making it suitable for industrial promotion and applicable to oral care and oral medical products.

Description

Technical Field

[0001] This invention belongs to the field of oral care products technology, specifically relating to a multi-effect oral care composition with excellent taste and its application. Background Technology

[0002] Glycyrrhizic acid (salts) is one of the main active ingredients in licorice, possessing antibacterial, anti-inflammatory, anti-allergic, anti-ulcer, and epithelial cell regeneration-promoting effects. Currently, glycyrrhizic acid (salts) and other licorice products are widely used in various oral care products, cosmetics, and pharmaceuticals. Glycyrrhizic acid (salts), glycyrrhetinic acid, and their derivatives are used in toothpaste, mouthwash, etc., effectively preventing and treating oral diseases such as oral ulcers, gingivitis, and periodontitis, and also serving as sweeteners to improve product taste.

[0003] For decades, in vitro experiments and clinical trial literature have confirmed that adding zinc salts to oral care products can effectively inhibit pathogenic bacteria and alleviate gum problems. Zinc citrate and zinc lactate are among the zinc salts that exist naturally in the human body. Currently, the antibacterial mechanism of zinc ions is still in the inferential stage. The antibacterial effect of zinc salts is mainly based on the zinc ion dissolution antibacterial theory, that is, dissolved zinc ions come into contact with bacteria and produce an antibacterial effect.

[0004] Glycyrrhizic acid (salt) is both hydrophilic and lipophilic. Theoretically, combining it with zinc salts in oral care products could yield products that combine the advantages of both. Furthermore, the sweetener effect of glycyrrhizic acid (salt) could effectively mask the metallic taste and bitterness of zinc ions, improving the palatability of zinc-containing oral care products. However, during actual research and development, the inventors discovered that adding both substances simultaneously leads to the formation of insoluble zinc glycyrrhizate precipitate. According to the industry standard QB / T 2945-2012 "Oral Cleaning and Care Liquids" issued by the Ministry of Industry and Information Technology, the clarity requirement for oral cleaning and care liquids such as mouthwashes is: the solution should be clear and free of mechanical impurities at temperatures above 5°C. Therefore, currently, it is difficult to achieve the combined application of glycyrrhizic acid (salt) and soluble zinc salts in aqueous oral cleaning and care liquids.

[0005] Chinese patent CN1193760C discloses a zinc glycyrrhizate solution composition and its preparation process: the zinc glycyrrhizate co-solvent is one of the following substances: citric acid and its potassium, sodium, and iron salts; tartaric acid and its potassium, sodium, and iron salts; glucose and its potassium, sodium, and iron salts; para-aminosalicylic acid and its potassium, sodium, and iron salts; the ratio of zinc glycyrrhizate to co-solvent is 1:0.4-1:1.5, and the concentration of the zinc glycyrrhizate solution is 0.01-10%. Among the above co-solvents, only citric acid and its potassium and sodium salts are widely used as pH adjusters in oral care products. Other co-solvents are limited in their application due to reasons such as not being listed in the toothpaste raw material catalog and limited compatibility in oral care product formulations. For example, para-aminosalicylic acid preparations are the main drugs for treating tuberculosis, hyperthyroidism, and ulcerative colitis, and are not suitable for use in oral care products. Therefore, how to simultaneously add glycyrrhizic acid (salt) and zinc salt to oral care products while ensuring that both are fully effective is a problem that urgently needs to be solved in this field. Summary of the Invention

[0006] The present invention aims to provide a multi-effect oral care composition with excellent taste, in order to solve the technical problem that it is difficult to simultaneously add glycyrrhizic acid (salt) and soluble zinc salt in oral care products of the prior art and effectively exert the efficacy of both.

[0007] To achieve the above objectives, the present invention adopts the following technical solution:

[0008] A multi-effect oral care composition with excellent taste, comprising sophorolipids, zinc ions, and glycyrrhizic acid or its salts in a weight ratio of 0.01-10:0.01-1:0.01-7.

[0009] This technical solution also provides the application of a multi-effect oral care composition with excellent taste in the preparation of oral care products.

[0010] Furthermore, the zinc ions are derived from soluble zinc salts; the glycyrrhizic acid or its salts are soluble glycyrrhizic acid or its salts.

[0011] Furthermore, the soluble zinc salt includes at least one of zinc citrate, zinc acetate, zinc lactate, zinc gluconate, and zinc chloride; the soluble glycyrrhizic acid or its salt includes at least one of glycyrrhizic acid, potassium glycyrrhizate, dipotassium glycyrrhizate, disodium glycyrrhizate, trisodium glycyrrhizate, and ammonium glycyrrhizate.

[0012] Furthermore, the oral care products include at least one of toothpaste, liquid toothpaste, mouthwash, tooth powder, oral spray, dental gel, dental paste, and polishing agent.

[0013] Furthermore, in oral care products, the added amounts of sophorolipids, zinc ions, and glycyrrhizic acid or their salts are 0.01-10%, 0.01-1%, and 0.01-7%, respectively.

[0014] Furthermore, the oral care product also includes a matrix; the matrix includes at least one of a humectant, an abrasive, a thickener, a surfactant, a solubilizer, a sweetener, a preservative, a flavor modifier, and water.

[0015] Furthermore, the oral care product is toothpaste, which is prepared by the following method: mixing and stirring a humectant and a thickener evenly; adding a sweetener and a preservative and stirring evenly; adding an oral care composition and stirring thoroughly; adding an abrasive and water and stirring evenly; adding a fragrance modifier and stirring thoroughly; vacuum degassing to complete the toothpaste preparation.

[0016] Furthermore, the oral care product is a mouthwash; the added amounts of sophorolipids, zinc ions, and glycyrrhizic acid or their salts are 0.01-5%, 0.01-0.5%, and 0.01-3.5%, respectively; the mouthwash also includes 1-50% humectant, 0.1-20% solubilizer, and 0.1-5% fragrance.

[0017] Furthermore, the mouthwash is prepared by the following method: a humectant and water are stirred and homogenized; an oral care composition is then added and stirred evenly; a fragrance and a solubilizer are then added and stirred evenly to obtain the mouthwash.

[0018] The principle and beneficial effects of this technical solution are as follows:

[0019] Zinc salts and glycyrrhizic acid (salts), among other naturally derived raw materials, possess advantages such as high safety and good stability. Combining these two substances in oral care products, while simultaneously incorporating their respective advantages, can significantly enhance the quality of oral care products. However, in practice, it has been found that the combined application of zinc salts and glycyrrhizic acid (salts) in aqueous systems results in precipitation, affecting the efficacy of both substances and the sensory properties of the product. This technical solution addresses this problem by adding sophorolipids, which increases the solubility of the precipitate. Sophorolipids are a natural biosurfactant produced by the fermentation of non-pathogenic yeast and have an excellent taste. Sophorolipids exhibit a certain inhibitory effect on oral pathogens (including Streptococcus mutans, oral streptococci, thrombocytococci, Neisseria mucosae, and Actinomyces negrius), and also demonstrate a relatively ideal inhibitory and destructive effect on dental plaque biofilms. Therefore, this raw material has broad application prospects in oral care products. Sophorolipids are classified into lactone and acid types. They can be extracts or concentrates from fermentation broths, or pure products obtained through separation and purification with organic solvents. They can be liquids, semi-solids, solid pastes, or powders. Sophorolipids can be purchased (CAS 148409-20-5). Chinese patents CN110156845B and CN113336807B disclose sophorolipid separation and purification technologies that can achieve a purity of over 90% for acid or lactone-type sophorolipid products.

[0020] In summary, the combined use of zinc salts and glycyrrhizic acid (salts) offers multiple advantages. For example, the combination of zinc citrate and dipotassium glycyrrhizate exhibits synergistic antibacterial effects and possesses anti-inflammatory, anti-ulcer, and epithelial cell regeneration-promoting properties. The sweetener effect of dipotassium glycyrrhizate effectively masks the metallic taste and bitterness of zinc ions. Furthermore, the introduction of potassium ions into this system provides an anti-dentin hypersensitivity effect. While the combined use of zinc salts and glycyrrhizic acid (salts) offers numerous advantages, a drawback is the formation of zinc glycyrrhizate precipitate, limiting their combined application in aqueous solutions. To address the shortcomings of existing technologies, this invention combines sophorolipids, zinc salts, and glycyrrhizic acid (salts), unexpectedly discovering that sophorolipids not only inhibit the formation of zinc glycyrrhizate precipitate from zinc salts and glycyrrhizic acid (salts), promoting the formation of a stable aqueous solution system, but also further enhance the antibacterial and anti-biofilm effects of the composition. Moreover, this composition has an excellent taste, making it highly suitable for industrial application in oral care and dental products. Attached Figure Description

[0021] Figure 1 The image shows the solubility test results of Experiment Example 1 of this invention.

[0022] Figure 2 These are typical image results of the inhibition zone test in Experiment Example 2 of this invention. Detailed Implementation

[0023] The present invention will be further described in detail below with reference to embodiments, but the implementation of the present invention is not limited thereto. Unless otherwise specified, the technical means used in the following embodiments and experimental examples are conventional means well known to those skilled in the art, and the materials and reagents used can all be obtained commercially.

[0024] Example 1: Preparation of oral care composition

[0025] The oral care composition consists of the following ingredients: sophorolipids, zinc ions, and glycyrrhizic acid or its salts in a mass ratio of 0.01-10:0.01-1:0.01-7.

[0026] If oral care products are prepared using the above-described oral care composition, each 100 parts of the oral care product contains 0.01-10 parts of sophorolipid, 0.01-1 parts of zinc ions, and 0.01-7 parts of glycyrrhizic acid or its salts, i.e., the mass percentages of sophorolipid, zinc ions, and glycyrrhizic acid or its salts are 0.01-10%, 0.01-1%, and 0.01-7%, respectively. Oral care products include toothpaste, liquid toothpaste, mouthwash, tooth powder, oral spray, dental gel, dental paste, polishing agents, etc.

[0027] Zinc ions are provided in the form of soluble zinc salts, including zinc citrate trihydrate and / or zinc lactate. Glycyrrhizic acid or its salts are provided in soluble forms, including dipotassium glycyrrhizate and / or disodium glycyrrhizate. The sophorolipids of this invention can be obtained through fermentation, and can be fermentation broth extracts or concentrates, or pure products obtained through separation and purification with organic solvents, and can be liquid, semi-solid, solid paste, or powder. Sophorolipids can be obtained commercially, with CAS number 148409-20-5. Sophorolipids are classified into lactone type and acid type. The sophorolipid separation and purification technologies disclosed in Chinese patents CN110156845B and CN113336807B can achieve a purity of over 90% for acid-type or lactone-type sophorolipid products. In subsequent experiments of this technical solution, for ease of research, all sophorolipids were obtained commercially and were lactone-type sophorolipids with a purity of not less than 90%.

[0028] Oral care products include oral care compositions and bases, the bases of which include humectants, abrasives, thickeners, surfactants, solubilizers, sweeteners, preservatives, flavor modifiers, and water.

[0029] When the oral care product is toothpaste, the preparation method is as follows:

[0030] (1) Mix the humectant and thickener evenly; (2) Add the sweetener and preservative and mix evenly; (3) Add the oral care composition and mix thoroughly; (4) Add the abrasive and water, mix evenly, then add the aroma modifier and mix thoroughly; (5) Degas under vacuum to complete the ointment preparation. In (3), the specific method of mixing the three substances is as follows (preparation method of oral care composition): First, mix sophorolipids and zinc ions (zinc salt) evenly, then add glycyrrhizic acid (salt) and stir until evenly dispersed and clear. The mixing method of the three substances has no significant effect on the final effect. In subsequent studies, a specific mixing method will be selected to ensure the parallelism of the experiment, that is, the above mixing method will be used.

[0031] When the oral care product is mouthwash, the preparation method is as follows:

[0032] (1) Homogenize the humectant and water; (2) Add the oral care composition and stir evenly; (3) Add the fragrance and solubilizer and stir evenly to obtain mouthwash. In (2), the three substances are mixed in the following way (preparation method of oral care composition): First, sophorolipid and zinc ions (zinc salt) are mixed evenly, then glycyrrhizic acid (salt) is added and stirred until evenly dispersed and clear.

[0033] Experiment Example 1: Solubility Test Experiment

[0034] In this experiment, different solutes were dispersed in water, and the pH of the solution was adjusted to 6.85. The dissolution of the solutes was observed visually, and the transmittance of the solution was measured at a wavelength of 430 nm using a UV-Vis spectrophotometer. The higher the transmittance, the higher the clarity. The mixing method of the test substances was as follows: first, sophorolipid (co-solvent) and zinc ions (zinc salt) were mixed evenly, and then glycyrrhizic acid (salt) was added and stirred until evenly dispersed and clear. As a control experiment, sophorolipid can be replaced with rhamnolipid or poloxamer according to the formula in Table 1, and the mixing order is still the same as above. For the experimental group without adding a co-solvent, it is only necessary to directly mix zinc ions (zinc salt) and glycyrrhizic acid (salt) thoroughly.

[0035] For detailed appearance photos of solutions A, B, C, and D, please refer to... Figure 1 The formula is shown in Table 1. When zinc citrate trihydrate solution is mixed with dipotassium glycyrrhizate solution, zinc glycyrrhizate precipitates from the water, causing the solution to become turbid. Figure 1 A), with a transmittance of 75.5% (Table 1, control group 1). In a mixed solution of zinc citrate trihydrate and dipotassium glycyrrhizate, the addition of 0.04% sophorolipid caused partial dissolution of all three substances in water, increasing clarity. Figure 1 B), with a transmittance of 87.3% (Table 1, Group 2). If 0.1% sophorolipid is added, all three substances become soluble in water, forming a transparent solution. Figure 1C), with a transmittance of 94.8% (Table 1, Group 3). Rhamnolipids and sophorolipids are both natural glycolipid surfactants and also have certain antibacterial effects. In a mixed solution of zinc citrate trihydrate and dipotassium glycyrrhizate, the addition of 0.1%-0.5% rhamnolipids did not significantly improve the clarity of the solution. Figure 1 D, specifically showing the case with the addition of 0.1% rhamnolipid), the transmittance is less than 75% (Table 1, Comparison Groups 2-4). In addition to rhamnolipid, the solubilizing effect of the surfactant poloxamer on the solution system was also analyzed in the comparative experiment. The results showed that the transmittance of the solution system was not improved (Table 1, Comparison Groups 5-7).

[0036] Therefore, the results indicate that sophorolipids can inhibit the formation of zinc glycyrrhizate precipitate from zinc salts and glycyrrhizic acid (salt), promoting the formation of a stable aqueous solution system. A turbid and unstable aqueous solution system affects both the clarity and taste of the final product, and also makes it difficult for the active ingredients to fully exert their effects when they are in an insoluble state.

[0037] Table 1: Transmittance Measurement of Solution Systems

[0038]

[0039]

[0040] Experimental Example 2: Antibacterial Ring Test

[0041] The experimental method referenced the inhibition zone test section of the 2002 edition of the *Disinfection Technical Specifications*. Considering the presence of precipitation in some solution samples, Oxford cups were used instead of filter paper for the test. 200 μL of the test solution was added to each Oxford cup. The test strain was *Staphylococcus aureus*, and each test group underwent at least three biological replicates. According to the evaluation criteria of the *Disinfection Technical Specifications*, an inhibition zone with an average diameter less than or equal to 7 mm (filter paper diameter 5 mm + 2 mm) was considered to have no antibacterial effect; an inhibition zone with an average diameter greater than 7 mm was considered to have antibacterial effect. Because Oxford cups were used instead of filter paper in this experiment, and the diameter of the Oxford cups is 8 mm, the evaluation criteria were adjusted accordingly: an inhibition zone with an average diameter less than or equal to 10 mm (i.e., Oxford cup diameter 8 mm + 2 mm) was considered to have no antibacterial effect; an inhibition zone with an average diameter greater than 10 mm was considered to have antibacterial effect. The experimental groups and results are as follows:

[0042] (1) Sample A was a 0.5% sophorolipid solution with an inhibition zone diameter of 10±0.4 mm; it was determined to have no antibacterial effect (although existing technology reports that sophorolipid has antibacterial effect, the concentration of 0.5% is too low and does not reach the minimum inhibitory concentration).

[0043] (2) Sample B was a 0.2% zinc citrate trihydrate solution with an inhibition zone diameter of 10±0.5 mm; it was determined to have no antibacterial effect (although existing technology reports that zinc citrate has antibacterial effects, the concentration of 0.2% is too low and does not reach the minimum inhibitory concentration).

[0044] (3) Sample C is a 0.1% dipotassium glycyrrhizate solution. At this concentration, the minimum inhibitory concentration against Staphylococcus aureus was not reached, and the diameter of the inhibition zone was less than 10 mm (i.e., there was no antibacterial effect. Although existing technology reports that dipotassium glycyrrhizate has antibacterial effect, the concentration of 0.1% is too low and the minimum inhibitory concentration was not reached).

[0045] (4) Sample BC was a mixed solution containing 0.2% zinc citrate trihydrate and 0.1% dipotassium glycyrrhizate, with an inhibition zone diameter of 15.2 ± 0.6 mm;

[0046] (5) Samples ABC were mixed solutions containing 0.5% sophorolipid, 0.2% zinc citrate trihydrate and 0.1% dipotassium glycyrrhizate, with an inhibition zone diameter of 19.3±0.5 mm.

[0047] See typical photos of inhibition zone test results. Figure 2 .

[0048] Experimental results show that the combined use of zinc citrate and dipotassium glycyrrhizate has a synergistic effect on antibacterial activity. From the experimental data, group (2) using 0.2% zinc citrate trihydrate solution alone had an average inhibition zone diameter of 10 mm, which is only equal to the threshold (10 mm) for determining the drug to have an antibacterial effect, therefore it was judged to have no antibacterial effect. Group (3) using 0.1% dipotassium glycyrrhizate solution alone did not exceed the threshold (10 mm) for determining the drug to have an antibacterial effect, therefore it was judged to have no antibacterial effect. However, group (4) using a combination of 0.2% zinc citrate trihydrate and 0.1% dipotassium glycyrrhizate increased the average inhibition zone diameter to approximately 15.2 mm, exceeding the threshold (10 mm) for determining the drug to have an antibacterial effect by about 5 mm. The combined use of the two significantly enhanced the antibacterial effect, and there was a synergistic effect between them. If there is no synergistic effect, then according to the common understanding of those skilled in the art, the combined effect of the two should be similar to the sum of the effects of group (2) + group (3). The sum of the effects of group (2) + group (3) is basically no antibacterial effect, while in fact group (4) has a significant antibacterial effect, achieving an improvement in antibacterial effect from none to something compared to group (2) and group (3). However, when zinc citrate and dipotassium glycyrrhizate are used together, precipitation will occur when preparing oral care products such as mouthwash. The precipitation affects the clarity of the product's sensory indicators and causes unpleasant taste in actual use. In addition, since the rate and time of precipitation in the product are uncontrollable, it will also affect the stability of the product and cause quality problems. Therefore, even if zinc ions and oxalate are used directly together to produce a synergistic effect in antibacterial effect, it is necessary to further improve the system formed by the two to increase the dissolution effect to eliminate precipitation and further improve product quality.

[0049] In addition, the addition of sophorolipids increased the diameter of the inhibition zone by 27%, further enhancing the antibacterial effect. From the experimental data, group (1) using 0.5% sophorolipid solution alone had an average inhibition zone diameter of 10 mm, which only reached the threshold (10 mm) for the drug to be considered to have an antibacterial effect, thus it was judged to have no antibacterial effect. Group (4) using 0.2% zinc citrate trihydrate and 0.1% dipotassium glycyrrhizate together resulted in an average inhibition zone diameter of approximately 15.2 mm, exceeding the threshold (10 mm) for the drug to be considered to have an antibacterial effect by approximately 5 mm, thus it was judged to have an antibacterial effect. Group (5) using 0.5% sophorolipids, 0.2% zinc citrate trihydrate, and 0.1% dipotassium glycyrrhizate together resulted in an average inhibition zone diameter of approximately 19.3 mm, exceeding the threshold (10 mm) for the drug to be considered to have an antibacterial effect by approximately 9 mm, thus it was judged to have an antibacterial effect. It is evident that the synergistic effect of using the three substances in combination is greater than that of using sophorolipid alone or the combination of zinc ions and oxalate (9.3mm > 0mm + 5.2mm). In addition to its inherent antibacterial effect, sophorolipid can also solve the solubility problem when zinc ions and oxalate are used together, further enhancing the antibacterial effect, while simultaneously increasing product stability and improving product appearance. The use of sophorolipid achieves multiple benefits, which the inventors could not have predicted before the experiment.

[0050] Experiment Example 3: Preparation and Antibacterial Effect Test of Mouthwash

[0051] In preparing the mouthwash, the oral care composition in the mouthwash contains the following components: sophorolipid 0.01-5%, zinc ions 0.01-0.5%, and dipotassium glycyrrhizate 0.01-3.5%. The mouthwash also includes the following ingredients in parts by weight: humectant 1-50%, solubilizer 0.1-20%, and fragrance 0.1-5%. The ingredients and their mass composition in each example and comparative example are shown in Table 2. Glycerin is used as a humectant, sorbitol and poloxamer are used as solubilizers, and the fragrance is peppermint. Sorbitol functions as both a humectant and a solubilizer; in the examples and comparative examples of preparing the mouthwash, sorbitol is classified as a solubilizer.

[0052] Table 2: Raw materials and amounts used in each test group (unit: g; total raw material amount for each example is 100g).

[0053]

[0054] Taking Group 1 as an example, the preparation method of mouthwash is specifically explained as follows: water and glycerin are stirred evenly, and then the oral care composition formed by sophorolipid, zinc citrate trihydrate and dipotassium glycyrrhizate (see Example 1 for preparation method) is added and mixed evenly; while stirring, the flavoring, sorbitol and poloxamer are slowly added and mixed evenly, filtered and packaged, and the mouthwash preparation is completed.

[0055] The antibacterial effects of the mouthwashes prepared in Table 2 were evaluated. The test method followed the antibacterial ring test section of the 2002 edition of the *Disinfection Technical Specifications*. Oxford cups were used instead of filter paper for the test. 200 μL of the test solution was added to each Oxford cup, and each test group was subjected to at least three biological replicates. The experimental results are shown in Table 3. The results showed that all three mouthwashes had good inhibitory effects on *Escherichia coli*, *Staphylococcus aureus*, and *Candida albicans*. The composition content of the mouthwash was positively correlated with its antibacterial performance; as the composition content increased, the antibacterial effect improved (Table 3, Groups 1-3). Mouthwashes without the composition, or with reduced levels of one or two ingredients in the composition, showed decreased antibacterial performance or no antibacterial effect (Table 3, Comparison Groups 1-7).

[0056] In control group 1, only 0.1% sophorolipid and 0.1% dipotassium glycyrrhizate were used. Neither reached the minimum inhibitory concentration (MIC) against the three bacteria, and the inhibition zone diameter shown on the culture medium was less than 10 mm. Therefore, "none" was entered in Table 3, indicating no inhibitory effect. Control group 2, unlike group 2, did not use 0.1% sophorolipid. The synergistic effect of sophorolipid on the other two substances disappeared, resulting in a more significant decrease in the inhibition zone compared to group 2. Similarly, control group 3, unlike group 2, did not use 0.1% dipotassium glycyrrhizate. The synergistic effect of dipotassium glycyrrhizate on the other two substances disappeared, resulting in a more significant decrease in the inhibition zone compared to group 2.

[0057] Control group 7, which did not use the oral care composition of the three substances in this regimen, did not produce a significant antibacterial effect (marked "None" in Table 3, inhibition zone diameter less than 10 mm). Control group 4, using 0.15% zinc citrate trihydrate alone, did not reach the minimum inhibitory concentration against the three bacteria and had no antibacterial effect (marked "None" in Table 3, inhibition zone diameter less than 10 mm). Control group 5, using 0.1% sophorolipid alone, did not produce a significant antibacterial effect (marked "None" in Table 3, inhibition zone diameter less than 10 mm). Control group 6, using 0.1% dipotassium glycyrrhizate alone, did not produce a significant antibacterial effect (marked "None" in Table 3, inhibition zone diameter less than 10 mm). Group 2, using the three substances in combination, produced a very significant antibacterial effect, indicating a clear synergistic effect among the three substances.

[0058] Table 3: Statistical results of inhibition zone diameter

[0059]

[0060] The above descriptions are merely embodiments of the present invention, and common knowledge such as specific technical solutions and / or characteristics are not described in detail here. It should be noted that those skilled in the art can make various modifications and improvements without departing from the technical solutions of the present invention, and these should also be considered within the scope of protection of the present invention. These modifications and improvements will not affect the effectiveness of the implementation of the present invention or the practicality of the patent. The scope of protection claimed in this application should be determined by the content of its claims, and the specific embodiments described in the specification can be used to interpret the content of the claims.

Claims

1. The application of a multi-effect oral care composition with excellent taste in the preparation of oral care products, characterized in that: Oral care compositions include sophorolipids, zinc ions, and glycyrrhizic acid or its salts; In oral care products, the amounts of sophorolipids, zinc ions, and glycyrrhizic acid or their salts added are 0.01-10%, 0.01-1%, and 0.01-7%, respectively; the oral care products also include a base; the base includes at least one of a humectant, abrasive, thickener, surfactant, solubilizer, sweetener, preservative, aroma modifier, and water; The sophorolipid is used to inhibit the formation of zinc glycyrrhizate precipitate by reacting zinc salts with glycyrrhizic acid or its salts; The oral care composition is used to enhance the antibacterial effect of oral care products.

2. The application of the multi-effect oral care composition with excellent taste according to claim 1 in the preparation of oral care products, characterized in that: The zinc ions are derived from soluble zinc salts; the glycyrrhizic acid or its salts are soluble glycyrrhizic acid or its salts.

3. The application of the multi-effect oral care composition with excellent taste according to claim 2 in the preparation of oral care products, characterized in that: The soluble zinc salt includes at least one of zinc citrate, zinc acetate, zinc lactate, zinc gluconate, and zinc chloride; the soluble glycyrrhizic acid or its salts include at least one of glycyrrhizic acid, potassium glycyrrhizate, dipotassium glycyrrhizate, disodium glycyrrhizate, trisodium glycyrrhizate, and ammonium glycyrrhizate.

4. The application of the multi-effect oral care composition with excellent taste according to claim 3 in the preparation of oral care products, characterized in that: The oral care products include at least one of toothpaste, mouthwash, tooth powder, oral spray, dental gel, dental paste, and polishing agent.

5. The application of the multi-effect oral care composition with excellent taste according to claim 4 in the preparation of oral care products, characterized in that, The oral care product is toothpaste, which is prepared by the following method: mixing and stirring a humectant and a thickener evenly; adding a sweetener and a preservative and stirring evenly; adding an oral care composition and stirring evenly; adding an abrasive and water and stirring evenly; adding a fragrance modifier and stirring evenly; vacuum degassing to complete the toothpaste preparation.

6. The application of the multi-effect oral care composition with excellent taste according to claim 5 in the preparation of oral care products, characterized in that, The oral care product is a mouthwash; the added amounts of sophorolipids, zinc ions and glycyrrhizic acid or their salts are 0.01-5%, 0.01-0.5% and 0.01-3.5%, respectively; the mouthwash also includes 1-50% humectant, 0.1-20% solubilizer and 0.1-5% fragrance.

7. The application of the multi-effect oral care composition with excellent taste according to claim 6 in the preparation of oral care products, characterized in that, The mouthwash is prepared by the following method: a humectant and water are stirred and homogenized; an oral care composition is then added and stirred evenly; a fragrance and a solubilizer are then added and stirred evenly to obtain the mouthwash.

Images