Artificial blood vessel having anti-bleeding function

Abstract

This invention provides an artificial blood vessel with anti-bleeding function. The vessel has a hollow tubular structure and comprises, from the inside out, a collagen membrane layer, a fabric composite layer, and a sprayed layer. The fabric composite layer is a composite fabric of polyester fibers and core-spun yarn, with the surface of the core-spun yarn containing a suitable amount of yarn hairs. The collagen membrane layer of this artificial blood vessel gives it low immunogenicity and good biocompatibility, and also facilitates cell endothelialization. The fabric composite layer utilizes its surface hairs to give the blood vessel excellent anti-bleeding properties and enhance the compliance of the artificial blood vessel. The sprayed layer can cover the hairs of the core-spun yarn, preventing excessive contact with blood and blood coagulation, and also improving the strength of the blood vessel. The artificial blood vessel of this invention not only has excellent anti-bleeding properties but also meets the requirements of compliance, compatibility, and strength for artificial blood vessels, which is of great significance for solving the bleeding problem of existing artificial blood vessels and promoting the application of artificial blood vessels.

Description

Technical Field

[0001] This invention relates to the field of biomaterials technology, and in particular to an artificial blood vessel with anti-bleeding function. Background Technology

[0002] Artificial blood vessels are medical devices used to replace or repair damaged or missing blood vessels. They are designed to restore blood flow to supply tissues and organs with the oxygen and nutrients they need. Artificial blood vessels have a wide range of applications, including heart surgery, arterial stenosis repair, and aneurysm repair, helping to improve patients' quality of life and saving lives in many cases. However, artificial blood vessels also present some challenges and limitations. Among these, the anti-bleeding function of artificial blood vessels is particularly important in clinical surgical applications. Severe bleeding from the artificial blood vessel after surgery can lead to several complications. For example:

[0003] (1) Bleeding may prevent the wound from closing completely, thereby increasing the risk of infection. Infection may cause symptoms such as fever, local redness and swelling, and pain, and in severe cases, it may threaten life. (2) Excessive bleeding may lead to excessive blood loss, causing anemia and circulatory instability, which may endanger life. (3) Bleeding may cause blood to accumulate and form hematomas between tissues. Small hematomas are usually absorbed on their own, but larger hematomas may increase pressure in the surgical area and affect postoperative recovery. (4) Bleeding may interfere with the normal healing process of the wound, prolong the recovery time, and increase the difficulty of postoperative care. (5) Bleeding may lead to damage to the function of combined organs. If bleeding causes insufficient oxygen supply or limited supply to organs (such as the heart, brain, etc.), it may affect their function. Therefore, solving the problem of bleeding in artificial blood vessels is of paramount importance for the development of artificial blood vessels.

[0004] In the prior art, an invention patent (application number CN 201580008464X) discloses an artificial blood vessel, introducing a fabric artificial blood vessel that involves minimal blood leakage and can balance antithrombotic and cell affinity; when using fabric artificial blood vessels in vascular surgery, it not only prevents leakage between fibers...

[0005] To prevent blood leakage, gels such as collagen and gelatin, which are absorbed within the body, are used to fill the gaps between the fibers. However, while this fabric artificial blood vessel reduces the risk of blood leakage, it also introduces other problems and risks, such as incomplete or uneven thrombus formation: thrombus formation within the blood vessel may be incomplete or uneven, leading to poor blood flow or even blockage of the vessel, causing complications such as local tissue ischemia and necrosis; and even if a thrombus forms, there is still a risk of blood leakage, as the thrombus may be broken by mechanical or internal forces, causing blood to leak into surrounding tissues.

[0006] The invention patent (application number CN 2023100926790) discloses a coated anti-leakage artificial blood vessel and its coating method. The method involves fully impregnating the fibers and monofilaments of the artificial blood vessel with a polyhydroxyalkanoate polymer solution to enhance its anti-leakage and anti-seepage effects while preventing hardening. The impregnated artificial blood vessel is then dried to improve the tightness and stability of the coating, achieving even better anti-leakage and anti-seepage effects. However, although polyhydroxyalkanoates (PHAs) are biocompatible and biodegradable, some potential hazards remain. First, the stability and durability of the PHA coating may be problematic. If the coating material is not stable enough, it may decompose or dissolve, weakening or eliminating its protective effect and increasing the risk of restenosis. Furthermore, PHA coatings may increase the risk of thrombosis. If the coating surface is not smooth enough or has minor irritants, it may promote platelet aggregation and thrombus formation, increasing the risk of vascular obstruction.

[0007] In view of this, it is necessary to design an improved artificial blood vessel with anti-leakage function to solve the above problems. Summary of the Invention

[0008] The purpose of this invention is to provide an artificial blood vessel with anti-bleeding function. A composite fabric is woven with core-spun yarn as the outer warp yarn and polyester fiber. This fabric is introduced into the structure of the artificial blood vessel. The yarn hairs on the surface of the core-spun yarn form a dense and uniformly distributed mesh layer on the surface of the composite fabric, thereby giving the artificial blood vessel excellent anti-bleeding function and solving the problem of bleeding in artificial blood vessels in the prior art.

[0009] To achieve the above-mentioned objectives, this invention provides an artificial blood vessel with anti-bleeding function. This artificial blood vessel has a hollow tubular structure, comprising, from the inside out, a collagen membrane layer, a fabric composite layer, and a sprayed layer. The fabric composite layer is a composite fabric of polyester fibers and core-spun yarn, and the surface of the core-spun yarn contains…

[0010] The yarn has fuzz, the length of which is 1-6 mm and the number of which is 1000-2000 strands / meter.

[0011] As a further improvement of the present invention, the sprayed coating is a polycaprolactone porous membrane, and the porosity of the polycaprolactone porous membrane is 20%~50%.

[0012] As a further improvement of the present invention, the fabric composite layer is a tubular fabric woven from polyester fibers and core-spun yarns. The core-spun yarns consist of core yarns and sheath yarns. The core yarns are polyester fibers, and the sheath yarns are polysaccharide fibers. The mass ratio of the core yarns to the sheath yarns is 1:(1~4).

[0013] As a further improvement of the present invention, the linear density of the core yarn is 20~40 tex; the sheath yarn is a staple fiber yarn, and the length of the staple fiber yarn is 20~120 mm.

[0014] As a further improvement of the present invention, the fabric composite layer is a woven fabric prepared by a jacquard machine, with the polyester fiber as the weft yarn and inner warp yarn, and the core-spun yarn as the outer warp yarn.

[0015] As a further improvement of the present invention, the polysaccharide fiber is a polysaccharide fiber with strong water absorption and solubility properties, and the polysaccharide fiber is one of glucomannan and chitosan.

[0016] As a further improvement of the present invention, the thickness of the collagen membrane is 0.1~0.3 mm, the porosity of the collagen membrane is 20%~50%, and the pore size ranges from 1 to 20 μm.

[0017] As a further improvement of the present invention, the coating layer is prepared by electrospinning technology, and the raw material of the coating layer is biodegradable polymer fiber; the fiber diameter of the biodegradable polymer fiber is 100nm~50μm, and the porosity of the coating layer is 20%~50%.

[0018] As a further improvement of the present invention, the length of the artificial blood vessel is greater than 10 cm, the inner diameter is 4~32 mm, and the wall thickness is 0.3~0.7 mm.

[0019] As a further improvement of the present invention, the thickness ratio of the collagen membrane layer, the fabric composite layer and the sprayed layer is 1:(1.5~3):(1~1.5).

[0020] The beneficial effects of this invention are:

[0021] 1. This invention provides an artificial blood vessel with anti-bleeding function, which is a hollow tubular structure comprising, from the inside out, a collagen membrane layer, a fabric composite layer, and a sprayed layer. The fabric composite layer is a tubular fabric woven from polyester fibers and core-spun yarn. The core yarn of the core-spun yarn is polyester fiber, and the sheath yarn is polysaccharide fiber. The surface of the core-spun yarn contains an appropriate amount of yarn hairiness. This invention uses core-spun yarn as the outer warp yarn and composites it with polyester fibers.

[0022] The fabric was synthesized and incorporated into the structure of the artificial blood vessel. The yarn hairs on the surface of the core-spun yarn formed a dense and uniformly distributed mesh layer on the fabric surface, giving the artificial blood vessel excellent anti-leakage function. This is of great significance for solving the bleeding problem of artificial blood vessels in the existing technology and promoting the application of artificial blood vessels.

[0023] 2. The artificial blood vessel of the present invention adopts a three-layer composite structure. The inner collagen membrane layer has low immunogenicity and good biocompatibility. Collagen can induce cell differentiation and promote wound healing, enabling the artificial blood vessel to maintain high biological activity in the human body. At the same time, the collagen membrane has micropores, which can promote endothelial cell growth and facilitate cell endothelialization. The middle fabric composite layer has excellent anti-seepage properties. The polyester fiber has good elasticity, which can enhance the conformity with human blood vessels. The polysaccharide fiber of the core-spun yarn can absorb water in the blood to achieve a coagulation effect. In addition, the core-spun yarn, as the outer warp yarn, makes the surface of the fabric composite layer dense and compact like a tile, which is not easy to seep blood. The outermost spray coating layer can cover the core-spun yarn fibers, preventing them from excessively contacting blood and causing blood coagulation. The composite structure of the coating and fibers can strengthen the tubular fabric layer, enhance the bonding force, and improve the strength of the blood vessel. Based on the above structure, the three-layer artificial blood vessel designed in this invention not only has excellent anti-leakage performance, but also meets the requirements for the compliance, compatibility and strength of artificial blood vessels.

[0024] 3. The fabric composite layer of the artificial blood vessel of the present invention uses polyester fiber as the weft yarn and inner warp yarn, and core-spun yarn as the outer warp yarn. A hairy structure is formed on the surface of the fabric composite layer, while the interior is still mainly composed of polyester fiber. Combined with the inner collagen membrane layer, this avoids the problem of blood clotting caused by hairs coming into contact with blood inside the blood vessel. The hairy structure on the outer surface of the fabric forms a dense mesh structure, which reduces the permeability of the artificial blood vessel and gives it excellent anti-seepage performance. At the same time, the hairs are covered by an external spray coating, which prevents the hairs from causing blood clotting and improves the compliance of the artificial blood vessel. Attached Figure Description

[0025] Figure 1 is a schematic diagram of the cross-sectional structure and partial structure of the fabric composite layer of an artificial blood vessel with anti-bleeding function according to the present invention.

[0026] Figure 2 is a schematic diagram of the structure of core-spun yarn in an artificial blood vessel with anti-bleeding function.

[0027] Figure Labels

[0028] 1- Artificial blood vessel with anti-bleeding function; 110- Collagen membrane layer; 120- Fabric composite layer; 121- Core-spun yarn; 130- Spray coating layer. Detailed Implementation

[0029] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be described in detail below with reference to the accompanying drawings and specific embodiments.

[0030] It should also be noted that, in order to avoid obscuring the present invention with unnecessary details, only the structures and / or processing steps closely related to the present invention are shown in the accompanying drawings, while other details that are not closely related to the present invention are omitted.

[0031] Additionally, it should be noted that the terms “comprising,” “including,” or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0032] Please refer to Figures 1 and 2. An artificial blood vessel 100 with anti-bleeding function is described. This artificial blood vessel has a hollow tubular structure, comprising, from the inside out, a collagen membrane layer 110, a fabric composite layer 120, and a sprayed coating layer 130. The fabric composite layer 120 is a composite fabric of polyester fiber and core-spun yarn 121. The surface of the core-spun yarn 121 contains yarn hairs, with a yarn hair count of 1000-2000 strands / meter. This artificial blood vessel is created by combining core-spun yarn 121 as the outer warp yarn with polyester fiber to form a fabric, which is then incorporated into the structure of the artificial blood vessel. The yarn hairs on the surface of the core-spun yarn 121 form a dense and uniformly distributed mesh layer on the fabric surface, giving the artificial blood vessel excellent anti-bleeding function. This is of great significance for solving the bleeding problem of existing artificial blood vessels and promoting the application of artificial blood vessels.

[0033] Specifically, the artificial blood vessel of the present invention has a three-layer composite structure. The inner collagen membrane layer 110 has low immunogenicity and good biocompatibility. Collagen can induce cell differentiation and promote wound healing, maintaining high bioactivity of the artificial blood vessel in the human body. Simultaneously, the collagen membrane has micropores, which can promote endothelial cell growth and facilitate endothelialization. The middle fabric composite layer 120 has excellent anti-seepage properties. The polyester fibers have good elasticity, enhancing conformity to human blood vessels, while the sheath polysaccharide fibers of the core-spun yarn 121 can absorb water from the blood to achieve a coagulation effect. Furthermore…

[0034] The core-spun yarn 121, as the outer warp yarn, makes the surface of the fabric composite layer dense and compact like tiles, making it less prone to blood seepage; the outermost spray coating layer 130 can cover the fibers of the core-spun yarn 121, preventing excessive contact with blood and causing blood clotting, and can also strengthen the tubular fabric layer, enhance the bonding force, and improve the strength of blood vessels.

[0035] Specifically, the yarn hair length is 1-6 mm. The core-spun yarn 121, acting as the outer warp yarn, makes the hair on the surface of the fabric composite layer 120 dense and compact, like tiles, preventing blood seepage. However, if the amount of yarn hair in the fabric composite layer 120 is excessive, it will result in poor coverage of the sprayed coating layer 130, or excessive hair on the inner wall of the fabric composite layer 120, leading to blood clotting due to direct and excessive contact with the hair. Therefore, the amount of yarn hair needs to be strictly limited. Furthermore, the length of the yarn hair also affects the amount of hair on the surface of the fabric composite layer 120, thus impacting the effectiveness of the artificial blood vessel in preventing blood seepage.

[0036] The spray coating 130 is a polycaprolactone porous membrane with a porosity of 20%~50%. As a collagen membrane, the polycaprolactone membrane not only prevents blood vessel leakage, but also prevents blood leakage because artificial blood vessels need to exchange energy and substances in the human body. The porous nature of the polycaprolactone membrane ensures that the artificial blood vessels can transport substances and function normally while preventing blood leakage.

[0037] The fabric composite layer 120 is a tubular fabric woven from polyester fibers and core-spun yarn 121. The core-spun yarn 121 consists of a core yarn and a sheath yarn. The core yarn is made of polyester fiber, and the sheath yarn is made of polysaccharide fiber, with a core-to-sheath yarn mass ratio of 1:(1~4). The linear density of the core yarn is 20~40 tex; the sheath yarn is a staple fiber with a length of 20~120 mm. Thus, the fabric composite layer 120, under the influence of the polyester fibers, provides good elasticity and compliance of the blood vessel, while the core-spun yarn 121 provides excellent anti-leakage performance for the artificial blood vessel.

[0038] In some specific embodiments, the polysaccharide fiber is a fiber with strong water absorption and solubility properties. The polysaccharide fiber is one of glucomannan and chitosan. The polysaccharide fiber has good water absorption and can play a role in blood clotting in artificial blood vessels.

[0039] The composite fabric layer 120 is a woven fabric produced using a large jacquard loom, with polyester fibers as the weft and inner warp yarns, and core-spun yarn 121 as the outer warp yarn. This double-sided jacquard fabric layer not only has good mechanical properties, improving the durability of the artificial blood vessel, but the addition of core-spun yarn 121 also creates a fuzzy structure on the surface of the composite fabric layer, while the interior remains primarily composed of polyester fibers. Combined with the inner collagen membrane layer 110, this prevents the fuzzy structure inside the blood vessel from coming into contact with the blood and causing blood clotting. The fuzzy structure on the outer surface of the fabric forms a dense mesh structure.

[0040] The permeability of the artificial blood vessel is reduced, giving it excellent anti-seepage properties; at the same time, the feathers are coated with a 130 coating, which prevents the feathers from causing blood clotting and improves the compliance of the artificial blood vessel.

[0041] More specifically, the collagen membrane 110 has a thickness of 0.1–0.3 mm, a porosity of 20%–50%, and a pore size range of 1–20 μm. The collagen membrane 110 is fabricated using electrospinning technology, specifically by forming the collagen membrane 110 on the surface of a cylindrical mold by rotating and winding a collagen solution onto the surface of the mold.

[0042] In some specific embodiments, the coating layer 130 is also made by electrospinning technology, and its raw material is a biodegradable polymer material. The diameter of the biodegradable polymer fiber is 100 nm to 50 μm, and the porosity of the coating layer 130 is 20% to 50%.

[0043] In some specific embodiments, the artificial blood vessel is longer than 10 cm, has an inner diameter of 4-32 mm, and a wall thickness of 0.3-0.7 mm. The thickness ratio of the collagen membrane layer 110, the fabric composite layer 120, and the sprayed layer 130 is 1:(1.5-3):(1-1.5).

[0044] The three-layer artificial blood vessel designed in this invention not only possesses excellent anti-leakage performance but also meets the requirements for compliance, biocompatibility, and strength of artificial blood vessels. The anti-leakage artificial blood vessel 100 can be prepared using the following methods in practical applications, specifically including:

[0045] S 1. A collagen film layer 110 is prepared on the surface of a cylindrical mold by rotating and winding a collagen solution using electrospinning technology.

[0046] S2. Using polyester fiber as the weft yarn and inner warp yarn, and core-spun yarn as the outer warp yarn, a tubular fabric composite layer 120 is obtained by weaving and is covered on the surface of the collagen membrane layer 110 in step S1.

[0047] S3. Electrospinning is used to spin polycaprolactone onto the surface of the fabric composite layer 120 to form a sprayed layer 130, thus obtaining an artificial blood vessel 100 with anti-bleeding function.

[0048] Example 1

[0049] This embodiment provides an artificial blood vessel with anti-bleeding function and its preparation method, including the following steps:

[0050] S 1. A collagen film layer 110 is prepared on the surface of a cylindrical mold by rotating and winding a collagen solution using electrospinning technology; wherein the thickness is 0.2 mm, the porosity is 30%, and the average pore size is...

[0051] The diameter is 10 μm;

[0052] S2. Using polyester fiber as the weft and inner warp yarn, and core-spun yarn 121 as the outer warp yarn, a tubular fabric composite layer 120 is woven using a large jacquard machine and covered on the surface of the collagen membrane layer 110 in step S1; wherein, the surface of the core-spun yarn contains yarn hairs, the number of yarn hairs is 1600 hairs / meter, and the average length of the hairs is 6 mm.

[0053] The core yarn of core-spun yarn 121 is polyester fiber, and the sheath yarn is chitosan fiber with strong water absorption and solubility properties. The mass ratio of core yarn to sheath yarn is 1:2. The linear density of the core yarn is 30 tex, and the average length of the chitosan fiber is 50 mm.

[0054] S3. Polycaprolactone fibers are sprayed onto the surface of the fabric composite layer 120 using electrospinning technology. The average diameter of the fibers is 10 μm, forming a sprayed layer 130 with a porosity of 30%, thus obtaining an artificial blood vessel 100 with anti-bleeding function. The artificial blood vessel is 50 cm long, has an inner diameter of 20 mm, and a wall thickness of 0.5 mm. The thickness ratio of the collagen membrane layer 110, the fabric composite layer 120, and the sprayed layer 130 is 1:1.3:1.5.

[0055] The artificial blood vessel prepared in Example 1 was tested for compliance, strength, and permeability. The results showed that the compliance of the artificial blood vessel in this example was 20%~25%, the vascular mechanical properties were 42~45 N / cm, the vascular puncture strength was >16 N / cm, and the permeability was less than 2.5 mL / (cm²·min), which is better than the permeability of artificial blood vessels in the prior art (5~20 mL / (cm²·min)). The above test results show that the artificial blood vessel not only has excellent anti-leakage performance, but also meets the requirements for compliance and strength of artificial blood vessels.

[0056] Comparative Example 1

[0057] Comparative Example 1 provides an artificial blood vessel and its preparation method. Compared with Example 1, the difference is that the outer warp yarn in the fabric composite layer 120 of Comparative Example 1 is not core-spun yarn 121, but polyester fiber. The rest is roughly the same as that of Example 1, and will not be described again here.

[0058] Comparative Example 2

[0059] Comparative Example 2 provides an artificial blood vessel and its preparation method. Compared with Example 1, the difference is that the surface of the core-spun yarn 121 used in Comparative Example 2 is treated to be almost free of yarn fuzz. The rest is roughly the same as in Example 1, and will not be described again here.

[0060] Comparative Example 3

[0061] Comparative Example 3 provides an artificial blood vessel and its preparation method. Compared with Example 1, the difference is that the artificial blood vessel in Comparative Example 3 does not contain the spray coating 130. Otherwise, it is roughly the same as Example 1 and will not be described again here.

[0062] Comparative Example 4

[0063] Comparative Example 4 provides an artificial blood vessel and its preparation method. Compared with Example 1, the difference is that the number of yarn hairs on the surface of the core-spun yarn used in Comparative Example 4 is 3000 yarns / meter. The rest is roughly the same as in Example 1, and will not be repeated here.

[0064] The permeability of the artificial blood vessels prepared in Comparative Examples 1-4 was tested. It was found that the fabric layer in Comparative Examples 1-2 did not contain any fibers, had a high permeability, and poor anti-bleeding function. Although the artificial blood vessels in Comparative Examples 3-4 had good anti-bleeding performance, they were found to easily cause blood coagulation when applied to animals, indicating poor practicality.

[0065] In summary, the present invention provides an artificial blood vessel with anti-bleeding function, which is a hollow tubular structure, comprising, from the inside out, a collagen membrane layer, a fabric composite layer and a sprayed layer. The fabric composite layer is a composite fabric made of polyester fiber and core-spun yarn woven together. The core yarn of the core-spun yarn is polyester fiber and the sheath yarn is polysaccharide fiber. The surface of the core-spun yarn contains an appropriate amount of yarn hair. This artificial blood vessel employs a three-layer composite structure. The inner collagen membrane layer exhibits low immunogenicity and excellent biocompatibility. Collagen can induce cell differentiation and promote wound healing, maintaining high bioactivity of the artificial blood vessel in the human body. Simultaneously, the collagen membrane's micropores promote endothelial cell growth and facilitate endothelialization. The middle fabric composite layer possesses excellent anti-seepage properties. Polyester fibers exhibit good elasticity, enhancing compliance with human blood vessels, while the polysaccharide fibers of the core-spun yarn absorb water from the blood, achieving a clotting effect. Furthermore, the core-spun yarn, acting as the outer warp yarn, ensures a dense and compact surface on the fabric composite layer, preventing blood leakage. The outermost coating layer covers the fibers of the core-spun yarn, preventing excessive contact with blood and blood clotting, and also strengthens the tubular fabric layer, enhancing adhesion and improving vascular strength. Based on this structure, the three-layer artificial blood vessel designed in this invention not only possesses excellent anti-seepage properties but also meets the requirements for compliance, biocompatibility, and strength of artificial blood vessels. This invention uses core-spun yarn as the outer warp yarn and composites it with polyester fibers to obtain a fabric, which is then incorporated into the structure of artificial blood vessels. The fabric utilizes the yarn hairs on the surface of the core-spun yarn to form a dense and uniformly distributed mesh layer.

[0066] This gives artificial blood vessels excellent anti-leakage function, which is of great significance for solving the bleeding problem of artificial blood vessels in existing technologies and promoting the application of artificial blood vessels.

[0067] The above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. An artificial blood vessel with anti-bleeding function, characterized in that, The artificial blood vessel is a hollow tubular structure, consisting of a collagen membrane layer, a fabric composite layer, and a sprayed layer from the inside out. The fabric composite layer is a composite fabric of polyester fiber and core-spun yarn. The surface of the core-spun yarn contains yarn hairs, the length of which is 1-6 mm and the number of which is 1000-2000 yarn hairs per meter.

2. The artificial blood vessel with anti-bleeding function according to claim 1, characterized in that, The sprayed coating is a polycaprolactone porous membrane with a porosity of 20% to 50%.

3. The artificial blood vessel with anti-bleeding function according to claim 1, characterized in that, The fabric composite layer is a tubular fabric woven from polyester fibers and core-spun yarn. The core-spun yarn consists of a core yarn and a sheath yarn. The core yarn is made of polyester fiber, and the sheath yarn is made of polysaccharide fiber. The mass ratio of the core yarn to the sheath yarn is 1:(1-4).

4. The artificial blood vessel with anti-bleeding function according to claim 3, characterized in that, The linear density of the core yarn is 20-40 tex; the sheath yarn is a staple fiber yarn with a length of 20-120 mm.

5. The artificial blood vessel with anti-bleeding function according to claim 3, characterized in that, The fabric composite layer is a woven fabric prepared by a jacquard machine, with the polyester fiber as the weft yarn and inner warp yarn, and the core-spun yarn as the outer warp yarn.

6. The artificial blood vessel with anti-bleeding function according to claim 3, characterized in that, The polysaccharide fiber is a polysaccharide fiber with water absorption and solubility properties, and the polysaccharide fiber is one of glucomannan and chitosan.

7. The artificial blood vessel with anti-bleeding function according to claim 1, characterized in that, The thickness of the collagen membrane is 0.1–0.3 mm, the porosity of the collagen membrane is 20%–50%, and the pore size ranges from 1 to 20 μm.

8. The artificial blood vessel with anti-bleeding function according to claim 1, characterized in that, The artificial blood vessel has a length greater than 10cm, an inner diameter of 4-32mm, and a wall thickness of 0.3-0.7mm.

9. The artificial blood vessel with anti-bleeding function according to claim 1, characterized in that, The coating layer is prepared by electrospinning technology, and the raw material of the coating layer is biodegradable polymer fiber; the fiber diameter of the biodegradable polymer fiber is 100nm to 50μm, and the porosity of the coating layer is 20% to 50%.

10. The artificial blood vessel with anti-bleeding function according to claim 8, characterized in that, The thickness ratio of the collagen membrane layer, the fabric composite layer, and the sprayed layer is 1:(1.5~3):(1~1.5).

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