An explosion-proof, multi-functional granulation, drying, and sizing integrated machine

Abstract

This invention discloses an explosion-proof, multi-functional granulation, drying, and sizing integrated machine, comprising an upper chamber, a lower chamber, a cylinder cover, a material cylinder, a stirring system, a granulation system, and a lifting device. Its key feature is that it further includes a granulator and a locking device. The locking device comprises several components evenly distributed circumferentially on the outer side of the cylinder cover and fixedly connected to the frame panel. After the material cylinder and cylinder cover are sealed closed, the locking device locks the material cylinder and cylinder cover in place. The locking device is strong enough to withstand the energy generated by an explosion within the material cylinder, thereby preventing the explosion from spreading to the outside of the equipment and causing damage to personnel and surrounding facilities. This invention integrates three processes into one machine, saving equipment procurement costs, reducing energy consumption, maintenance, and operating costs; eliminating the need for material transfer between different devices reduces the risk of material leakage, minimizes material loss, and improves product yield; and reduces the equipment's footprint, improving the utilization rate of cleanroom space.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical manufacturing technology, and in particular to an explosion-proof, multifunctional granulation, drying, and granulation integrated machine. Background Technology

[0002] Existing pharmaceutical production equipment has a single function. The three processes of granulation, drying and sizing require three pieces of equipment: a wet granulator, a fluidized bed dryer and a sizing machine. The equipment maintenance and procurement costs are high, the energy consumption is high, and there will be residues when materials are transferred between different equipment, resulting in high material loss.

[0003] Moreover, for flammable and explosive products, existing equipment does not have corresponding explosion-proof structures. It only achieves explosion-proof function by selecting explosion-proof components, which cannot fundamentally eliminate the hazards caused by explosion. Once an explosion is caused by improper operation or other accidents, if the structure does not meet the explosion-proof requirements, the energy generated by the explosion will spread outward, causing damage to personnel and surrounding facilities. Summary of the Invention

[0004] To address the problems of existing pharmaceutical production equipment having limited functionality, requiring three separate machines for granulation, drying, and sizing processes, resulting in high equipment maintenance and procurement costs, high energy consumption, material residue during transfer between different machines, and high material loss, and lacking corresponding explosion-proof structures, this invention provides an explosion-proof multifunctional granulation, drying, and sizing integrated machine. By integrating the three processes into one machine, it saves on equipment procurement costs and reduces energy consumption, maintenance, and operating costs. Furthermore, by incorporating a locking device, the integrated machine structure meets explosion-proof requirements, significantly improving safety and making it suitable for the production of flammable and explosive products.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] An explosion-proof multi-functional granulation, drying, and sizing integrated machine includes an upper chamber, a lower chamber, a cylinder cover, a material cylinder, a stirring system, a granulation system, and a lifting device. The lower chamber is located below the upper chamber and supports it. The upper chamber includes an outer cover and a frame panel. The frame panel is located at the bottom of the outer cover, and the cylinder cover is located on the frame panel. A feeding device and a spray gun are provided on the front side of the upper surface of the cylinder cover. Both the feeding device and the spray gun are located on the outside of the outer cover. The stirring system is used to mix powder raw materials and binders evenly and bind them into clumps. It includes a stirring drive assembly located above the cylinder cover, a stirring shaft connected to the output shaft of the stirring drive assembly, and a stirring paddle fixedly connected to the lower end of the stirring shaft. The stirring drive assembly is located inside the outer cover of the upper chamber, and the stirring shaft passes through the center of the cylinder cover. The granulation system is designed to cut agglomerated raw materials into individual granules. It includes a granulation drive assembly located above the cylinder cover, a granulation blade shaft connected to the output shaft of the granulation drive assembly, and several vertically arranged granulation blades connected to the granulation blade shaft. The granulation drive assembly is located inside the outer casing of the upper housing. The granulation blade shaft passes through the cylinder cover and is rotatably sealed. The material cylinder is located directly below the cylinder cover on the front side of the lower housing and has a double-layer jacket structure. During operation, a circulating heat source is introduced into the jacket to dry the granulated drug granules. The heat source is hot water, steam, or hot oil. A discharge device is located at the lower right bottom of the material cylinder. The lifting device is located on the frame panel and is used to raise the material cylinder to a sealed connection with the cylinder cover, or to lower the material cylinder and separate it from the cylinder cover after operation.

[0007] The feature is that it also includes a granulator and a locking device. The granulator is used to shape dry granules of uneven size into uniform granules. It is located on the front side of the lower box and is hinged to the front side of the lower box, so that the granulator and the hinge shaft form a rotatable connection. During operation, the lifting device lifts the material cylinder to a sealed connection with the cylinder cover. The granulator rotates to the left until the granulator inlet is connected to the discharge device, and the granulation operation can be carried out.

[0008] The locking device consists of several parts, which are evenly distributed in a circle on the outside of the cylinder cover and fixedly connected to the frame panel. After the material cylinder and the cylinder cover are sealed and closed, the locking device locks the material cylinder and the cylinder cover. The strength of the locking device is sufficient to resist the energy generated by the explosion inside the material cylinder, thereby preventing the explosion from spreading to the outside of the equipment and causing damage to external personnel and surrounding facilities.

[0009] As a further improvement to this technology, the locking device includes a locking cylinder, a slider sleeve, a pull plate, and a slider. The slider sleeve is fixedly connected to the frame panel. The locking cylinder is located on the upper plane of the slider sleeve. The piston rod end of the locking cylinder is fixedly connected to the pull plate. The inner side of the pull plate is fixedly connected to one end of the slider. The other end of the slider is sleeved inside the slider sleeve, forming a linearly movable connection with the slider sleeve. Before the cylinder cover and the material cylinder are closed, the slider is in a retracted state. During operation, after the cylinder cover and the material cylinder are sealed and closed, the locking device is activated, causing the slider to extend and insert into the lower end face of the upper flange of the material cylinder, thus locking the cylinder cover and the material cylinder.

[0010] As a further improvement to this technology, a breather assembly is also provided above the cylinder head. The breather assembly includes a barrel, an air tank, a backflush pipe assembly, a pulse solenoid valve, a filter element, a vacuum pipe, and a vacuum valve. The upper end of the barrel is provided with a high-pressure sealing cap, and the lower end is provided with a mounting flange. The cylinder head is provided with a third flange that is fixedly connected to the mounting flange. During operation, the inner cavity of the barrel is connected to the inside of the material cylinder. The upper end of the barrel is provided with a sealing partition, and multiple filter elements are provided in the middle of the sealing partition. A backflush pipe assembly is provided above the filter elements. The other end of the backflush pipe assembly passes through the outer wall of the barrel. The air tank is located on the outside of the barrel and stores compressed air inside. It is connected to the extended end of the backflush pipe assembly through the pulse solenoid valve. The vacuum pipe is located on the outer wall of the barrel and is staggered from the backflush pipe assembly. The vacuum valve is located at the outer end of the vacuum pipe and is connected to an external vacuum pump.

[0011] As a further improvement to this technology, the bottom of the material cylinder is provided with an air blowing pipe that communicates with the inside of the material cylinder. The other end of the air blowing pipe is connected to an external air source for blowing compressed air or nitrogen into the material cylinder during drying. This blows the water vapor accumulated inside the material to the surface of the material, which is then vacuumed away by the breather assembly, thereby accelerating the drying speed.

[0012] A sampling device is provided at the lower left bottom of the material cylinder for taking samples from the material cylinder for testing, which facilitates real-time monitoring of the dried material in the material cylinder.

[0013] As a further improvement to this technology, a first flange is provided in the middle of the cylinder cover for installing the stirring drive assembly, and a second flange is provided on the left side of the middle of the cylinder cover for installing the granulation drive assembly. The cylinder cover is also provided with two cleaning pipes, which are connected to the cleaning pipeline for cleaning the material cylinder after the work is completed, to prevent the material from sticking to the inner wall of the material cylinder and affecting the quality of the next production.

[0014] As a further improvement to this technology, the cylinder cover is also equipped with an explosion-proof sight light and an explosion-proof camera for real-time monitoring of the working conditions inside the material cylinder; the cylinder cover is also equipped with a negative pressure sensor for monitoring the pressure inside the material cylinder.

[0015] As a further improvement to this technology, the cylinder head is also provided with a baffle. The lower end of the baffle extends into the material cylinder to prevent eddies from forming inside the material cylinder and to enhance the mixing effect. In addition, the baffle integrates a temperature sensor, which can detect the material temperature in real time.

[0016] As a further improvement to this technology, the lifting device is provided in two parts, which are symmetrically installed on the left and right sides of the cylinder cover on the frame panel. The lifting device includes a lifting cylinder and a guide shaft. The upper left and right sides of the material cylinder are provided with lifting lugs at positions corresponding to the lifting cylinder. The piston rod of the lifting cylinder is fixedly connected to the corresponding lifting lug.

[0017] As a further improvement to this technology, the material cylinder is located in the middle of the movable box, with the upper end of the material cylinder extending out of the movable box for easy sealing and docking with the cylinder cover. The piston rod of the lifting cylinder is fixedly connected to the upper side wall of the movable box and the corresponding lifting lug, so that the material cylinder and the movable box rise and fall together.

[0018] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0019] 1. This invention integrates three processes into one device, saving equipment procurement costs, reducing energy consumption and maintenance and operating costs; materials do not need to be transferred between different devices, reducing the risk of material leakage, reducing material loss, and improving material yield; reducing equipment footprint and improving the utilization rate of cleanroom space.

[0020] 2. By setting a locking device, the present invention enables the equipment to meet explosion-proof requirements, greatly improving safety and making it suitable for the production of flammable and explosive products;

[0021] 3. This invention achieves vacuum feeding by setting up a breather assembly, which improves feeding efficiency and saves on manual feeding costs. During drying, vacuuming creates negative pressure inside the material cylinder, which lowers the boiling point of the liquid in the material. Combined with the heat source drying operation in the material cylinder jacket, the liquid in the material evaporates faster, thereby greatly improving drying efficiency.

[0022] 4. The present invention has an air blowing pipe set at the bottom of the material cylinder, which can be connected to the air source during drying to blow air into the material cylinder, blowing the water vapor accumulated in the material to the surface of the material, and then removing it by vacuuming, which further improves the drying efficiency.

[0023] 5. By setting up explosion-proof sight lights and explosion-proof cameras, the present invention can monitor the production situation inside the material cylinder in real time. By setting up negative pressure sensors, it can monitor the internal pressure of the material cylinder in real time, further improving the safety and production stability of the equipment. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the external structure in a non-working state according to an embodiment of the present invention;

[0025] Figure 2 This is a schematic diagram of the internal structure of the present invention in its working state according to an embodiment;

[0026] Figure 3 This is a schematic diagram of the locking device structure according to an embodiment of the present invention;

[0027] Figure 4 This is a schematic diagram of the locking device for locking the cylinder cover and the material cylinder according to an embodiment of the present invention;

[0028] Figure 5 This is a schematic diagram of the respirator assembly structure according to an embodiment of the present invention;

[0029] Figure 6 This is a schematic diagram of the structure above the cylinder head in an embodiment of the present invention.

[0030] In the diagram: 1. Upper housing; 101. Upper housing cover; 1011. Trapezoidal groove; 102. Frame panel; 2. Cylinder head; 201. First flange; 202. Second flange; 203. Third flange; 3. Feeding device; 4. Spray gun; 5. Mixing system; 501. Mixing drive assembly; 502. Mixing shaft; 503. Mixing paddle; 6. Granulation system; 601. Granulation drive assembly; 602. Granulation knife shaft; 603. Granulation knife; 7. Lifting device; 701. Hydraulic cylinder; 702. Guide shaft; 703. Guide sleeve; 8. Moving housing; 9. Material cylinder; 901. Discharge device; 902. Air blowing pipe; 903. Picking... Sample device, 904, lifting lug, 10, baffle, 11, granulator, 1101, vacuum discharger, 12, lower box, 13, locking device, 1301, locking cylinder, 1302, slider sleeve, 1303, pull plate, 1304, slider, 14, breather assembly, 1401, barrel, 1402, vacuum tube, 1403, vacuum tube valve, 1404, backflush tube assembly, 1405, pulse solenoid valve, 1406, air tank, 1407, filter element, 1408, mounting flange, 1409, sealing partition, 15, explosion-proof sight light, 16, explosion-proof camera, 17, negative pressure sensor, 18, cleaning pipe. Detailed Implementation

[0031] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0032] like Figures 1 to 6As shown, this embodiment of the invention includes an upper housing 1, a lower housing 12, a cylinder cover 2, a material cylinder 9, a stirring system 5, a granulation system 6, a lifting device 7, a granulator 11, and a locking device 13. The lower housing 12 is located below the upper housing 1 and is used to support the upper housing 1. The upper housing 1 includes an upper housing outer cover 101 and a frame panel 102. The frame panel 102 is located at the bottom of the upper housing outer cover 101. The cylinder cover 2 is located on the frame panel 102. A feeding device 3 and a spray gun 4 are provided on the front side of the upper plane of the cylinder cover. Feeding device 3 is used for feeding powder, and spray gun 4 is used for feeding binder. The front side of the upper casing 101 is provided with an inwardly recessed trapezoidal groove 1011, and both feeding device 3 and spray gun 4 are located in the trapezoidal groove 1011 on the outer side of the upper casing. The stirring system 5 is used to stir the powder raw materials and binder evenly and bind them into a ball. It includes a stirring drive assembly 501 located above the cylinder cover 2, a stirring shaft 502 connected to the output shaft of the stirring drive assembly 501, and a stirring mechanism fixedly connected to the lower end of the stirring shaft. The slurry 503 and the stirring drive assembly 501 are located inside the outer cover 101 of the upper housing. The stirring shaft 502 passes through the center of the cylinder cover 2 and is rotatably sealed. The granulation system 6 is used to cut the raw materials that have agglomerated after stirring into individual granules. It includes the granulation drive assembly 601 located above the cylinder cover 2, the granulation blade shaft 602 connected to the output shaft of the granulation drive assembly 601, and several vertically arranged granulation blades 603 connected to the granulation blade shaft. The granulation drive assembly 601 is located inside the outer cover 101 of the upper housing. Inside, the granulation blade shaft 602 passes through the cylinder cover and rotates in a sealed fit; the material cylinder 9 is located directly below the cylinder cover 2 on the front side of the lower box 12, and is designed with a double-layer jacket structure. During operation, circulating hot water (or steam or hot oil) is introduced into the jacket to dry the granulated drug granules. The material cylinder 9 has a discharge device 901 at the lower right bottom; the lifting device 7 is located on the frame panel 102 and is used to lift the material cylinder 9 to a sealed connection with the cylinder cover 2, or to lower the material cylinder 9 to separate it from the cylinder cover 2 after the operation is completed.

[0033] The pelletizer 11 is used to shape dry granules of uneven size into uniform granules. It is located on the front side of the lower box 12 and is hinged to the front side of the lower box, so that the pelletizer 11 and the hinge shaft form a rotatable connection. During operation, the lifting device 7 lifts the material cylinder 9 to a sealed connection with the cylinder cover 2. The pelletizer 11 rotates to the left until the feed port of the pelletizer is connected to the discharge device 901, and the pelletizing operation can be carried out. The discharge port of the pelletizer is equipped with a vacuum discharge device 1101.

[0034] The locking device 13 has four pieces, which are evenly distributed in a circle on the outside of the cylinder cover 2 and fixedly connected to the frame panel 102. After the material cylinder 9 and the cylinder cover 2 are sealed and closed, the locking device 13 locks the material cylinder 9 and the cylinder cover 2. The strength of the locking device 13 is sufficient to resist the energy generated by the explosion inside the material cylinder 9, thereby preventing the explosion from spreading to the outside of the equipment and causing damage to external personnel and surrounding facilities.

[0035] Preferably, the locking device 13 includes a locking cylinder 1301, a slider sleeve 1302, a pull plate 1303, and a slider 1304. The slider sleeve 1032 is fixedly connected to the frame panel 102. The locking cylinder 1301 is located on the upper surface of the slider sleeve 1302. The piston rod end of the locking cylinder 1301 is fixedly connected to the pull plate 1303. The inner side of the pull plate 1303 is fixedly connected to one end of the slider 1304. The other end of the slider 1304 is sleeved inside the slider sleeve 1302, forming a linearly movable connection with the slider sleeve 1302. Before the cylinder cover 2 and the material cylinder 9 are closed, the slider 1304 is in a retracted state. During operation, after the cylinder cover 2 and the material cylinder 9 are sealed and closed, the locking device 13 is activated, causing the slider 1304 to extend and insert into the lower end face of the upper flange of the material cylinder 9, thus locking the cylinder cover 2 and the material cylinder 9.

[0036] In this embodiment, the cross-section of slider 1305 is 70×35mm, and the yield strength of the material used is 1000MPa. Therefore, the shear force that each slider 1305 can withstand can be calculated as F = cross-sectional area S × yield strength σ = 70×35×1000 = 2.45×10 6 N=245T, while the pressure generated by the explosion is generally calculated at 12 bar. Taking a material cylinder with a diameter of 1000mm as an example, the resulting explosive force F=1.2×3.14×500×500=94.2T. Through calculation, it can be seen that the four evenly distributed locking devices are sufficient to resist the explosive force generated by the explosion inside the material cylinder 5, thereby locking the explosion inside the material cylinder 9 and preventing the explosion from spreading to the outside of the equipment and causing damage to external personnel and surrounding facilities.

[0037] Preferably, a breather assembly 14 is also provided above the cylinder head 2. The breather assembly 14 includes a barrel 1401, an air tank 1406, a backflush pipe assembly 1404, a pulse solenoid valve 1405, a filter element 1407, a vacuum pipe 1402, and a vacuum balloon valve 1403. The upper end of the barrel 1401 is provided with a high-pressure sealing cap, and the lower end is provided with a mounting flange 1408. The cylinder head 2 is provided with a third flange 203 that is fixedly connected to the mounting flange 1408. During operation, the inner cavity of the barrel 1401 is connected to the inside of the material cylinder 9. A sealing baffle 1409 is provided at the upper end of the barrel 1401 for sealing. Multiple filter elements 1407 are provided in the middle of the partition 1409. A backflush pipe assembly 1404 is provided above the filter elements 1407. The other end of the backflush pipe assembly 1404 passes through the outer wall of the barrel 1401. The air storage tank 1406 is located on the outside of the barrel 1401 and stores compressed air inside. It is connected to the extended end of the backflush pipe assembly 1404 through a pulse solenoid valve 1405. The vacuum pipe 1402 is located on the outer wall of the barrel 1401 and is set at a staggered position from the backflush pipe assembly 1404. The vacuum balloon valve 1403 is located at the outer end of the vacuum pipe 1402 and is connected to an external vacuum pump.

[0038] Preferably, the bottom of the material cylinder 9 is provided with an air blowing pipe 902 that communicates with the inside of the material cylinder 9. The other end of the air blowing pipe 902 is connected to an external air source for blowing compressed air or nitrogen into the material cylinder 9 during drying, blowing the water vapor accumulated in the material to the surface of the material, and then the breather assembly 14 will draw a vacuum to remove it, thereby accelerating the drying speed.

[0039] A sampling device 903 is provided at the lower left bottom of the material cylinder 9, which is used to take samples from the material cylinder 9 for testing, so as to facilitate real-time monitoring of the dried material in the material cylinder 9.

[0040] Preferably, the cylinder cover 2 has a first flange 201 in the middle for installing the stirring drive assembly 501, and a second flange 202 on the left side of the middle of the cylinder cover 2 for installing the granulation drive assembly 601. The cylinder cover 2 is also provided with two cleaning pipes 18, which are connected to the cleaning pipes and are used to clean the material cylinder 9 after the work is completed to prevent the material from sticking to the inner wall of the material cylinder 9 and affecting the quality of the product in the next production.

[0041] Preferably, the cylinder cover 2 is also equipped with an explosion-proof sight light 15 and an explosion-proof camera 16 for real-time monitoring of the working conditions inside the material cylinder 9; the cylinder cover 2 is also equipped with a negative pressure sensor 17 for monitoring the pressure inside the material cylinder.

[0042] Preferably, the cylinder head 2 is also provided with a baffle 10, the lower end of which extends into the material cylinder 9 to prevent eddies from forming in the material cylinder 9 and to enhance the mixing effect. The baffle 10 also integrates a temperature sensor to detect the material temperature in real time.

[0043] Preferably, the lifting device 7 comprises two components: a lifting cylinder 701 and a guide shaft 702. The two lifting cylinders 701 are symmetrically mounted on the left and right sides of the cylinder cover 2 on the frame panel 102. Lifting lugs 904 are provided on the upper left and right sides of the material cylinder 9, corresponding to the positions of the lifting cylinders 701. The piston rod of the lifting cylinder 701 is fixedly connected to the corresponding lifting lug 904. The two guide shafts 702 are symmetrically mounted on the corresponding lifting lugs 904, located in front of the piston rod of the lifting cylinder 701, with their upper ends passing through the frame panel 102, forming a linearly movable connection with the frame panel 102. The guide shafts 702 provide guidance for the lifting movement of the lifting device 7.

[0044] Preferably, the material cylinder 9 is located in the middle of the movable box 8, with the upper end of the material cylinder 9 extending out of the movable box 8 to facilitate sealing and docking with the cylinder cover 2. The piston rod of the lifting cylinder 701 is fixedly connected to the upper side wall of the movable box 8 and the corresponding lifting lug 904, so that the material cylinder 9 and the movable box 8 rise and fall together.

[0045] The workflow of this embodiment is as follows: The lifting device 7 is activated to lift the moving box 8 and the material cylinder 9 together until the material cylinder 9 is sealed to the cylinder cover 2. The locking device 13 is activated to lock the material cylinder 9 to the cylinder cover 2. The granulator 11 is rotated until its inlet aligns with the outlet device 901 of the material cylinder 9. The feeding device 3 is connected to the powder silo. The feeding device 3 and the vacuum valve 1403 are opened. The external vacuum pump is activated, creating a suction airflow in the inlet of the feeding device 3, the material cylinder 9, and the barrel 1401. The powder in the powder silo is automatically drawn into the material cylinder 9 and the barrel 1401 by the suction airflow. The powder is blocked by the filter element. The air is blocked below the sealing partition, separating it from the airflow to achieve vacuum feeding. After one minute, the PLC control system closes the vacuum valve 1403 and activates the pulse solenoid valve 1405 to backflush the filter element 1407 with compressed air from the air tank 1406, preventing the filter element from being clogged by the powder and causing the powder to fall into the material cylinder 9. After 2 seconds of pulse backflushing, the pulse solenoid valve 1405 is closed, and the vacuum valve 1403 is opened to continue vacuum feeding. Pulse backflushing is repeated every minute thereafter, greatly improving feeding efficiency and saving manual feeding costs. Once the required amount of material has been fed, the external vacuum pump and feeding device are turned off. 3. Then, start the spray gun 4 to spray a certain amount of binder into the material cylinder 9 according to the process requirements. Then, start the stirring drive assembly 501 to drive the stirring paddle 503 to stir the raw materials in the material cylinder 9. After the raw materials are stirred into agglomerates, turn off the stirring system 5 and start the granulation drive assembly 601 to drive multiple granulation blades 603 to cut the agglomerates into granules. After granulation, circulate hot water (or steam or hot oil) into the jacket of the material cylinder 9 to dry the granulated material in the material cylinder 9. At the same time, start the external vacuum pump and open the vacuum valve 1403 to create a vacuum, so that a negative pressure is formed in the material cylinder 9, which can reduce the liquid content in the material. Boiling point, and simultaneously turn on the external air source, blow compressed air or nitrogen into the material cylinder 9 through the air blowing pipe 902, blow the water vapor accumulated in the material to the surface of the material, and then the breather assembly 14 will draw a vacuum to remove it, which greatly speeds up the drying speed. After drying, turn off the external vacuum pump, the air blowing valve 1403 and the external air source, open the discharge device 902 at the bottom of the material cylinder 9, so that the dried particles can directly enter the feed port of the granulator 11, turn off the discharge device 902, start the granulator 11 to granulate, so that the unevenly sized dry particles are granulated into uniform particles, and finally discharge from the vacuum discharge device 1101 below the granulator 11.

[0046] This invention integrates granulation, drying, and sizing processes into one device, saving equipment procurement costs and reducing energy consumption, maintenance, and operating costs. The pharmaceutical powder does not need to be transferred between different devices, reducing the risk of powder leakage, reducing powder loss, and improving the yield of pharmaceutical products. At the same time, it reduces the equipment footprint and improves the utilization rate of cleanroom space.

[0047] The above are merely preferred embodiments of the present invention. It should be noted that those skilled in the art can make several improvements and substitutions without departing from the technical principles of the present invention, and these improvements and substitutions should also be considered within the scope of protection of the present invention.

Claims

1. An explosion-proof multi-functional granulation, drying, and sizing integrated machine, comprising an upper chamber, a lower chamber, a cylinder cover, a material cylinder, a stirring system, a granulation system, and a lifting device. The lower chamber is located below the upper chamber and supports it. The upper chamber includes an outer cover and a frame panel. The frame panel is located at the bottom of the outer cover. The cylinder cover is located on the frame panel. A feeding device and a spray gun are provided on the front side of the upper surface of the cylinder cover. Both the feeding device and the spray gun are located on the outside of the outer cover. The stirring system is used to mix powder raw materials and binders evenly and bind them into clumps. It includes a stirring drive assembly located above the cylinder cover, a stirring shaft connected to the output shaft of the stirring drive assembly, and a stirring paddle fixedly connected to the lower end of the stirring shaft. The stirring drive assembly is located inside the outer cover of the upper chamber, and the stirring shaft passes through the center of the cylinder cover. The granulation system is used to cut the raw materials that have agglomerated after stirring into individual granules. It includes a granulation drive assembly located above the cylinder cover, a granulation blade shaft connected to the output shaft of the granulation drive assembly, and several vertically arranged granulation blades connected to the granulation blade shaft. The granulation drive assembly is located inside the outer cover of the upper housing. The granulation blade shaft passes through the cylinder cover and is rotatably sealed. The material cylinder is located directly below the cylinder cover on the front side of the lower housing and has a double-layer jacket structure. During operation, a circulating heat source is introduced into the jacket to dry the granulated drug granules. The heat source is hot water, steam, or hot oil. A discharge device is located at the lower right bottom of the material cylinder. The lifting device is located on the frame panel and is used to lift the material cylinder to a sealed connection with the cylinder cover, or to lower the material cylinder to separate it from the cylinder cover after operation. Its features are: It also includes a granulator and a locking device. The granulator is used to shape dry granules of uneven size into uniform granules. It is located on the front side of the lower box and is hinged to the front side of the lower box, so that the granulator and the hinge shaft form a rotatable connection. During operation, the lifting device lifts the material cylinder to a sealed connection with the cylinder cover. The granulator rotates to the left until the granulator inlet is connected to the discharge device, and the granulation operation can be carried out. The locking device consists of several parts, which are evenly distributed in a circle on the outside of the cylinder cover and fixedly connected to the frame panel. After the material cylinder and the cylinder cover are sealed and closed, the locking device locks the material cylinder and the cylinder cover. The strength of the locking device is sufficient to resist the energy generated by the explosion inside the material cylinder, thereby preventing the explosion from spreading to the outside of the equipment and causing damage to external personnel and surrounding facilities. The cylinder head is also provided with a breather assembly, which includes a barrel, an air tank, a backflush pipe assembly, a pulse solenoid valve, a filter element, a vacuum tube, and a vacuum balloon valve. The bottom of the material cylinder is equipped with an air blowing pipe, which is connected to an external air source. It is used to blow compressed air or nitrogen into the material cylinder during drying, blowing the water vapor accumulated inside the material to the surface of the material, and then the breather assembly will draw a vacuum to remove it, thereby accelerating the drying speed.

2. The explosion-proof multi-functional granulation, drying, and sizing integrated machine according to claim 1, characterized in that: The locking device includes a locking cylinder, a slider sleeve, a pull plate, and a slider. The slider sleeve is fixedly connected to the frame panel. The locking cylinder is located on the upper plane of the slider sleeve. The piston rod end of the locking cylinder is fixedly connected to the pull plate. The inner side of the pull plate is fixedly connected to one end of the slider. The other end of the slider is sleeved inside the slider sleeve, forming a linearly movable connection with the slider sleeve. Before the cylinder cover and the material cylinder are closed, the slider is in a retracted state. During operation, after the cylinder cover and the material cylinder are sealed and closed, the locking device is activated, causing the slider to extend and insert into the lower end face of the upper flange of the material cylinder, locking the cylinder cover and the material cylinder.

3. The explosion-proof multi-functional granulation, drying, and sizing integrated machine according to claim 1, characterized in that: The upper end of the barrel is equipped with a high-pressure sealing cap, and the lower end is equipped with a mounting flange. The cylinder cover is equipped with a third flange that is fixedly connected to the mounting flange. During operation, the inner cavity of the barrel is connected to the inside of the material cylinder. The upper end of the barrel is equipped with a sealing partition, and multiple filter elements are arranged in the middle of the sealing partition. A backflush pipe assembly is arranged above the filter elements. The other end of the backflush pipe assembly passes through the outer wall of the barrel. The air storage tank is located on the outside of the barrel and stores compressed air inside. It is connected to the protruding end of the backflush pipe assembly through a pulse solenoid valve. The vacuum tube is located on the outer wall of the barrel and is staggered from the backflush pipe assembly. The vacuum balloon valve is located at the outer end of the vacuum tube and is connected to an external vacuum pump.

4. The explosion-proof multi-functional granulation, drying, and sizing integrated machine according to claim 1, characterized in that: A sampling device is provided at the lower left bottom of the material cylinder for taking samples from the material cylinder for testing, which facilitates real-time monitoring of the dried material in the material cylinder.

5. The explosion-proof multi-functional granulation, drying, and sizing integrated machine according to claim 1, characterized in that: The cylinder cover has a first flange in the middle for installing the stirring drive assembly, and a second flange on the left side of the middle of the cylinder cover for installing the granulation drive assembly. The cylinder cover also has two cleaning pipes connected to the cleaning pipeline for cleaning the material cylinder after the work is completed, to prevent the material from sticking to the inner wall of the material cylinder and affecting the quality of the next production.

6. The explosion-proof multi-functional granulation, drying, and sizing integrated machine according to claim 1, characterized in that: The cylinder cover is also equipped with an explosion-proof sight light and an explosion-proof camera for real-time monitoring of the working conditions inside the material cylinder; the cylinder cover is also equipped with a negative pressure sensor for monitoring the pressure inside the material cylinder.

7. The explosion-proof multi-functional granulation, drying, and sizing integrated machine according to claim 4, characterized in that: The cylinder head is also equipped with a baffle, the lower end of which extends into the material cylinder to prevent eddies from forming inside the cylinder and to enhance the mixing effect. The baffle also integrates a temperature sensor to detect the material temperature in real time.

8. The explosion-proof multi-functional granulation, drying, and sizing integrated machine according to claim 1, characterized in that: The lifting device consists of two parts, which are symmetrically installed on the left and right sides of the cylinder cover on the frame panel. The lifting device includes a lifting cylinder and a guide shaft. The upper left and right sides of the material cylinder are provided with lifting lugs corresponding to the lifting cylinder. The piston rod of the lifting cylinder is fixedly connected to the corresponding lifting lug.

9. The explosion-proof multi-functional granulation, drying, and sizing integrated machine according to claim 8, characterized in that: The material cylinder is located in the middle of the movable box, with its upper end extending out of the movable box for easy sealing and docking with the cylinder cover. The piston rod of the lifting cylinder is fixedly connected to the upper side wall of the movable box and the corresponding lifting lug, so that the material cylinder and the movable box rise and fall together.

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