An aqueous composition containing phenylethyl resorcinol, a method of preparation and use

Abstract

The present application relates to the cosmetic technical field, especially to a kind of water-based composition containing phenethyl resorcinol and preparation method and application, the preparation raw material of the water-based composition includes: phenethyl resorcinol nano-encapsulated body, oil, water, the mass ratio of the water and oil is (4-15):1.The present application creatively uses water-oil double-layer system to solve the discoloration problem of phenethyl resorcinol, reduces the discoloration risk of phenethyl resorcinol while skin feeling is promoted and appearance is innovated, effectively solves the problem of instability of phenethyl resorcinol in aqueous system, and reduces the irritability of phenethyl resorcinol to skin.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to an aqueous composition containing phenylethyl resorcinol, its preparation method, and its application. Background Technology

[0002] Phenethyl resorcinol is a highly active tyrosinase inhibitor. By inhibiting the activity of tyrosinase inhibitors, it reduces the rate and amount of melanin synthesis, making it a highly effective, fast-acting, and long-lasting whitening and brightening agent widely used in whitening and anti-aging cosmetics. However, due to its structural characteristics, phenylethyl resorcinol has poor solubility, making it difficult to integrate with other ingredients. It is only soluble in some oils and is easily oxidized and discolored, making it difficult to penetrate the stratum corneum to reach the whitening target area. It also has a certain degree of skin irritation, limiting its application to oil-water emulsion systems such as lotions and creams. It is less suitable for use in water-based systems such as water or serums, which have a lighter feel, thus restricting its application to some extent.

[0003] Chinese patent CN115531224A discloses a skin-whitening and anti-aging brightening lotion and its preparation method. It involves encapsulating poorly soluble and incompatible compounds such as phenylethyl resorcinol and honeysuckle flavonoids with cationic cyclodextrin, and combining this with citrus peel extract and daisy extract. This allows the skin-whitening and anti-aging lotion to form a deep, synergistic whitening and anti-aging pathway from the surface to the interior, maximizing its whitening and anti-aging effects. However, while the cyclodextrin encapsulation improves stability to some extent, it also affects the efficacy of phenylethyl resorcinol. Therefore, a method is needed that allows phenylethyl resorcinol to exert its full efficacy while maintaining stability. Summary of the Invention

[0004] The first aspect of the present invention provides an aqueous composition containing phenylethyl resorcinol, wherein the raw materials for preparing the aqueous composition include: phenylethyl resorcinol nano-encapsulations, oils, and water, wherein the mass ratio of water to oil is (4-15):1.

[0005] This invention aims to apply phenylethyl resorcinol to aqueous systems. To address its tendency to discolor in aqueous systems, this invention specifically utilizes nano-encapsulated phenylethyl resorcinol, which is milder, safer, and has higher bioavailability compared to untreated phenylethyl resorcinol. However, in actual research and development, the applicant discovered that even with phenylethyl resorcinol encapsulation, severe discoloration still occurs, resulting in poor storage stability in aqueous products. Preferably, the phenylethyl resorcinol encapsulation is purchased from Bestcare.

[0006] In some embodiments, the mass ratio of water to oil is (6-12):1.

[0007] In some embodiments, the mass ratio of water to oil is (8-10):1.

[0008] In some embodiments, the mass ratio of water to oil is 9:1.

[0009] In actual research and development, the applicant found that the mass ratio of water to oil does not have a significant impact on the stability of phenylethyl resorcinol inclusions in water-based products. However, considering the skin feel and usage effect of water-based products, the present invention preferably uses a mass ratio of water to oil of 9:1.

[0010] In some embodiments, the oil includes at least one of liquid paraffin, silicone oil, olive oil, isododecane, isopropyl myristate, isononyl isononanoate, meadowfoam seed oil, caprylic / capric triglyceride, coconut oil, castor oil, cottonseed oil, soybean oil, sesame oil, almond oil, tea seed oil, sea buckthorn oil, avocado oil, kukui nut oil, argan oil, walnut oil, cocoa butter, shea butter, and grapeseed oil.

[0011] In some embodiments, the oil includes at least one of liquid paraffin, silicone oil, olive oil, isododecane, isopropyl myristate, isononyl isononanoate, meadowfoam seed oil, and caprylic / capric triglyceride.

[0012] To improve the stability of phenylethyl resorcinol inclusions in water-based products, the applicant unexpectedly discovered in numerous experiments that using a water-oil bilayer system significantly reduces the discoloration of phenylethyl resorcinol inclusions, resulting in a lighter product color after long-term storage. Further exploration of different oil types revealed that various oils were effective, but only caprylic / capric triglycerides showed the best effect in reducing the discoloration of phenylethyl resorcinol inclusions. It is speculated that this is because the structure of this oil better prevents air from entering the water-based system, thus prolonging the stability time of the phenylethyl resorcinol inclusions.

[0013] In some embodiments, the mass of the phenylethyl resorcinol nano-encapsulations accounts for 0.6-5% of the mass of the aqueous composition.

[0014] In some embodiments, the raw materials for preparing the aqueous composition further include at least one of the following: humectant, thickener, brightener, preservative, pH adjuster, solubilizer, fragrance, and colorant.

[0015] This invention does not impose any special limitations on the moisturizer, which can be selected from commonly used types in the art, including but not limited to glycerin and trehalose.

[0016] This invention does not impose any specific limitations on the thickener, which can be selected from commonly used types in the art, including but not limited to xanthan gum and ammonium acryloyldimethyl taurate / VP copolymer.

[0017] This invention does not impose any specific limitations on brightening agents, which can be selected from commonly used types in the art, including but not limited to nicotinamide.

[0018] This invention does not impose any special limitations on preservatives, which can be selected from those commonly used in the art, including but not limited to hexanediol.

[0019] This invention does not impose any specific limitations on pH adjusters, which can be selected from commonly used types in the art, including but not limited to citric acid.

[0020] This invention does not impose any special limitations on the solubilizer, which can be selected from commonly used types in the art, including but not limited to PEG-40 hydrogenated castor oil.

[0021] This invention does not impose any special limitations on the fragrance agent, which can be selected from commonly used types in the field, including but not limited to plant fragrances.

[0022] This invention does not impose any special limitations on the colorant, which can be selected from commonly used types in the art, including but not limited to natural colorants.

[0023] A second aspect of the present invention provides a method for preparing an aqueous composition, the method comprising: mixing phenylethyl resorcinol nano-encapsulations with water to prepare an aqueous phase, and mixing the aqueous phase with an oil to obtain the final product.

[0024] A third aspect of the present invention provides the application of an aqueous composition in the preparation of toners, serums, essences, lotions, creams, facial cleansers, soaps, masks, gels, foundations, sunscreens, sunscreen sprays, and hydrating sprays.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] 1. This invention creatively uses a water-oil dual-layer system to solve the discoloration problem of phenylethyl resorcinol, reducing the risk of discoloration of phenylethyl resorcinol while improving the skin feel and innovative appearance.

[0027] 2. From the perspective of the skin feel and usage effect of water-based products, the present invention preferably uses a water to oil mass ratio of 9:1, which can further improve the user experience of the water-based composition.

[0028] 3. This invention effectively solves the problem of instability of phenylethyl resorcinol in aqueous systems by using the isolation effect of the water-oil bilayer system, while reducing the skin irritation of phenylethyl resorcinol.

[0029] 4. The aqueous composition of the present invention can be shaken well before use, which can increase the activity of phenylethyl resorcinol and enhance the user experience.

[0030] 5. The preparation process of the present invention is simple and low in cost, making it suitable for large-scale production. Attached Figure Description

[0031] Figure 1 The figure shows the stability test results of Example 1.

[0032] Figure 2 The graph shows the stability test results for Example 1 and Comparative Example 14.

[0033] Figure 3 The graph shows the stability test results of Example 1 and Comparative Examples 1-7.

[0034] Figure 4 The figure shows the stability test results for Comparative Examples 8-13. Detailed Implementation

[0035] Example 1

[0036] An aqueous composition containing phenylethyl resorcinol, wherein the raw materials for preparing the aqueous composition are shown in Table 1 by mass percentage, and the mass ratio of water to oil is 9:1.

[0037] Table 1

[0038]

[0039] Acryloyldimethyl taurate ammonium / VP copolymer, purchased from Clariant Chemicals Ltd.; PEG-40 hydrogenated castor oil, purchased from BASF Chemicals Ltd.

[0040] A method for preparing an aqueous composition, the method comprising: heating and homogenizing phenylethyl resorcinol nano-encapsulations together with a humectant, a thickener, and water to 88°C until completely dissolved, cooling to 45°C, adding a brightening agent, a preservative, a pH adjuster, a solubilizer, a fragrance, and a colorant, stirring evenly, filtering to prepare an aqueous phase, and mixing the aqueous phase with oil to obtain the final product.

[0041] Comparative Example 1

[0042] The difference between this comparative example and Example 1 is that the grease is liquid paraffin, purchased from Zhejiang Zhengxin Petroleum Technology Co., Ltd.

[0043] Comparative Example 2

[0044] The difference between this comparative example and Example 1 is that the grease is silicone oil, purchased from Dow (Zhangjiagang) Investment Co., Ltd.

[0045] Comparative Example 3

[0046] The difference between this comparative example and Example 1 is that the oil used is olive oil, purchased from Interfat SA.

[0047] Comparative Example 4

[0048] The difference between this comparative example and Example 1 is that the oil is isododecane.

[0049] Comparative Example 5

[0050] The difference between this comparative example and Example 1 is that the oil is isopropyl myristate.

[0051] Comparative Example 6

[0052] The difference between this comparative example and Example 1 is that the oil is isononyl isononanoate.

[0053] Comparative Example 7

[0054] The difference between this comparative example and Example 1 is that the oil is meadowfoam seed oil, purchased from Hemings UK Limited.

[0055] Comparative Example 8

[0056] The difference between this comparative example and Example 1 is that the mass ratio of water to oil is 4:1.

[0057] Comparative Example 9

[0058] The difference between this comparative example and Example 1 is that the mass ratio of water to oil is 6:1.

[0059] Comparative Example 10

[0060] The difference between this comparative example and Example 1 is that the mass ratio of water to oil is 8:1.

[0061] Comparative Example 11

[0062] The difference between this comparative example and Example 1 is that the mass ratio of water to oil is 10:1.

[0063] Comparative Example 12

[0064] The difference between this comparative example and Example 1 is that the mass ratio of water to oil is 12:1.

[0065] Comparative Example 13

[0066] The difference between this comparative example and Example 1 is that the mass ratio of water to oil is 15:1.

[0067] Comparative Example 14

[0068] The difference between this comparative example and Example 1 is that it does not contain oil.

[0069] Performance testing

[0070] Stability test:

[0071] Nine parallel samples prepared in Example 1 were placed in environments of -5℃, room temperature (25℃), 5℃, variable temperature (40℃ / 25℃ / -10℃ for three months), fluorescence, sunlight, 40℃, 45℃, and 50℃, respectively. The 50℃ environment was used for one month, and the other conditions were tested for three months. Photos of the samples after testing were taken and recorded. See details. Figure 1 The experimental results show that the material in this system undergoes a significant color change at 45℃, indicating that the system is quite sensitive to temperature, especially exhibiting obvious thermosensitivity. The color change is not deep after one month of testing at 50℃, showing that the thermosensitivity is closely related to time.

[0072] The samples prepared in Example 1 and Comparative Example 14 were placed at 45°C for 3 months, and photographs of the samples after testing were taken. See details below. Figure 2 As shown in the figure, the color change of the pure water system in Comparative Example 14 is much greater than that of the water-oil bilayer system in Example 1, ranging from a normal yellowing to a reddish color, and its heat sensitivity is much greater than that of the water-oil bilayer system.

[0073] The samples prepared in Example 1 and Comparative Examples 1-7 were placed at 50°C for one month, and photographs of the samples after testing were taken. See details below. Figure 3 As shown in the figure, caprylic / capric triglycerides exhibited better anti-discoloration effects.

[0074] The samples prepared in Comparative Examples 8-13 were simultaneously placed at 50℃ for one month, and photos of the samples after testing were taken and recorded. See details. Figure 4 As shown in the figure, the mass ratio of water to oil has no significant effect on the stability of phenylethyl resorcinol inclusions in water-based products.

Claims

1. An aqueous composition containing phenylethyl resorcinol, characterized in that, The raw materials for preparing the aqueous composition include: phenylethyl resorcinol nano-encapsulations, oils, and water, wherein the mass ratio of water to oil is (8-10):1; The oil is caprylic / capric triglyceride; The phenylethyl resorcinol inclusion complex was purchased from Bestcare. The method for preparing the aqueous composition includes: mixing phenylethyl resorcinol nano-encapsulations with water to prepare an aqueous phase, and mixing the aqueous phase with oil to obtain the final product. The aqueous composition is a water-oil bilayer system.

2. The aqueous composition according to claim 1, characterized in that, The mass ratio of water to oil is 9:

1.

3. The aqueous composition according to claim 1, characterized in that, The mass of the phenylethyl resorcinol nano-encapsulation accounts for 0.6-5% of the mass of the aqueous composition.

4. The aqueous composition according to any one of claims 1-3, characterized in that, The raw materials for preparing the aqueous composition also include at least one of the following: humectant, thickener, brightener, preservative, pH adjuster, solubilizer, fragrance, and colorant.

5. A method for preparing the aqueous composition according to claim 1, characterized in that, The preparation method includes: mixing phenylethyl resorcinol nano-encapsulations with water to prepare an aqueous phase, and mixing the aqueous phase with oil to obtain the final product.

6. The use of an aqueous composition according to any one of claims 1-3 in the preparation of toners, serums, essences, lotions, creams, facial cleansers, soaps, masks, gels, foundations, sunscreens, sunscreen sprays, and hydrating sprays.

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