Alkyl carboxylic acid compounds and their use
By providing a novel compound that directly activates oxidative soluble guanylate cyclase, the problem of sGC inactivation caused by oxidative stress is solved, enabling effective treatment and prevention of cardiovascular and fibrotic diseases.
CN117337278BActive Publication Date: 2026-06-09MEDSHINE DISCOVERY INC
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- MEDSHINE DISCOVERY INC
- Filing Date
- 2022-05-10
- Publication Date
- 2026-06-09
AI Technical Summary
Technical Problem
In the prior art, oxidative stress-induced inactivation of soluble guanylate cyclase leads to the progression of cardiovascular and fibrotic diseases, and there is a lack of effective activators that are independent of NO and heme cofactors.
Method used
A new class of compounds is provided as activators of soluble guanylate cyclase, which activate the oxidized sGC to produce cGMP by directly activating the sGC-cGMP signaling pathway.
Benefits of technology
This compound exhibits excellent in vitro stimulatory activity and pharmacokinetic properties, and can effectively activate oxidized sGCs, showing potential for the treatment and prevention of cardiovascular and fibrotic diseases.
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Figure CN117337278B_ABST
Abstract
The application relates to a series of alkyl carboxylic acid compounds and their applications, in particular to a compound shown in formula (II) and a pharmaceutically acceptable salt thereof.
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